ZFAND1 Gene
protein-coding GIFtS: 44
GCID: GC08M082613
|
|
zinc finger, AN1-type domain 1
| |
Aliases
for ZFAND1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Zinc Finger, AN1-Type Domain 11 2 | | FLJ140071 | | AN1-Type Zinc Finger Protein 12 |
| External Ids: | HGNC: 258581 | Entrez Gene: 797522 | Ensembl: ENSG000001042317 | UniProtKB: Q8TCF13 | | ORGUL members: | |
|---|
| NONCODE:n409092 n409089 | |
Export aliases for ZFAND1 gene to outside databasesPrevious GC identifers: GC08M082777 GC08M078103
|---|
Summaries
for ZFAND1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ZFAND1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008183.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZFAND1 gene promoter:
STAT5B STAT1 STAT4 STAT6 STAT1beta STAT1alpha HNF-1A HNF-1 STAT2 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZFAND1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFAND1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q21.13 Ensembl cytogenetic band: 8q21.13 HGNC cytogenetic band: 8q21.13ZFAND1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M082613: view genomic region
(about GC identifiers)
Start:
|
82,613,566 bp from pter |
End:
|
82,645,138 bp from pter |
Size:
|
31,573 bases |
Orientation:
|
minus strand |
ORGUL member locations:
Legend (see complete legend)
82613565 82623552 82633539 chr8
|
Proteins
for ZFAND1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZFAN1_HUMAN, Q8TCF1 (See
protein sequence)Recommended Name: AN1-type zinc finger protein 1 Size: 268 amino acids; 30787 Da
Secondary accessions: Q658R7 Q6IA32 Q6PGQ6 Q9H810Alternative splicing: 2 isoforms: Q8TCF1-1 Q8TCF1-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZFAND1: NX_Q8TCF1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TCF1
ZFAND1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001164267.1 NP_001164268.1 NP_078975.2
ENSEMBL proteins: ENSP00000430736 ENSP00000220669 ENSP00000429999 ENSP00000430499 ENSP00000428375 ENSP00000429527 ENSP00000428139 ENSP00000428927 ENSP00000428278 ENSP00000430214 ENSP00000429167 ENSP00000428101 ENSP00000427957 ENSP00000427811 ENSP00000430405 ENSP00000428527 ENSP00000430719
Human Recombinant Protein Products:
ZFAND1 Antibody Products:
Assay Products for ZFAND1: |
Protein
Domains /
Families
for ZFAND1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZFAND1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8TCF1ProtoNet protein and cluster: Q8TCF1 UniProtKB/Swiss-Prot: ZFAN1_HUMAN, Q8TCF1Similarity: Contains 2 AN1-type zinc fingers |
Function
for ZFAND1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFAND1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFAND1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): ZFAND1 (NM_024699) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZFAND1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFAND1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFAND1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
ZFAND1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZFAND1:
|
Pathways & Interactions
for ZFAND1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZFAND1
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for ZFAND1 (ENSP000002206694) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for ZFAND1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZFAND1
Search CenterWatch for drugs/clinical trials and news about ZFAND1 / ZFAN1
|
Transcripts
for ZFAND1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZFAND1 gene (3 alternative transcripts): NM_001170796.1 NM_001170797.1 NM_024699.2 Unigene Cluster for ZFAND1: Zinc finger, AN1-type domain 1 Hs.655453 [show with all ESTs]Unigene Representative Sequence: NR_03319318/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25): ENST00000524305(uc010lzx.2 uc003ycj.2 uc022awt.1 uc022awu.1 uc003yck.2)
ENST00000523096 ENST00000220669 ENST00000522520 ENST00000519338 ENST00000522032
ENST00000519464 ENST00000521895 ENST00000521287 ENST00000523431 ENST00000520635
ENST00000517588 ENST00000519523(uc022awv.1 uc022aww.1) ENST00000520604
ENST00000523361 ENST00000517450 ENST00000521742 ENST00000518419
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFAND1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFAND1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): ZFAND1 (NM_024699) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZFAND1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFAND1 |
Additional cDNA sequence: AK024069.1 AK225195.1 AK304111.1 BC022251.2 BC051857.1 BC056877.1 CR457323.1 NR_033193.1 NR_033194.1 NR_033195.1 NR_033196.1 19 DOTS entries: DT.100654487 DT.409315 DT.100870821 DT.121485419 DT.100654488 DT.97815093 DT.121485414 DT.109798 DT.303261 DT.91927156 DT.95115129 DT.100654492 DT.100857388 DT.102831583 DT.121485475 DT.121485490 DT.91725491 DT.99999485 DT.99995180 24/150 AceView cDNA sequences (see all 150): BP345698 AL833030 CA412820 BU159374 AL709159 CR625306 CD108172 CR609195 AI523843 BU158663 BC051857 BE018789 AI050998 AA452520 CA336883 BQ427843 CB136018 BG929103 AA460225 AW673167 BP367092 AI767012 AI968003 BG286221
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND1 (see all 11) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | · | 9d | · | 9e | · | 9f | · | 9g | · | 9h |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | - | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | - | | | | - | | - | | | | | | - | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | - | | | | - | | | | - | | - | | | | | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZFAND1
|
Expression
for ZFAND1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZFAND1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ZFAND1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZFAND1
SOURCE GeneReport for Unigene cluster: Hs.655453
SABiosciences Custom PCR Arrays for ZFAND1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZFAND1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZFAND1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFAND1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFAND1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFAND1 |
Orthologs
for ZFAND1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ZFAND1 gene from 8/22 species (see all 22) About this table
ENSEMBL Gene Tree for ZFAND1 (if available)
TreeFam Gene Tree for ZFAND1 (if available) |
Paralogs
for ZFAND1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZFAND1 gene
- ZFAND2B2 ZFAND2A2
1 SIMAP similar gene for ZFAND1 using alignment to 15 protein entries: ZFAN1_HUMAN (see all proteins):ZFAND2B
ZFAND1 for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for ZFAND1
PGOHUM00000256879 PGOHUM00000256880 PGOHUM00000245095 PGOHUM00000257076
|
Genomic Variants
for ZFAND1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZFAND1 (82613566 - 82645138 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZFAND1
1 CNV: 100403 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZFAND1 |
|
Disorders
/ Diseases
for ZFAND1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZFAND1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZFAND1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZFAND1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
|
External Searches for ZFAND1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZFAND1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZFAND1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZFAND1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZFAND1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZFAND1 gene:
Search GeneIP for patents involving ZFAND1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZFAND1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| | | | Search Tocris compounds for ZFAND1 |
| |  |  |  |  | | | | |
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 | | | ZFAND1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFAND1 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZFAND1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFAND1 |
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