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Aliases for ZFAND1 Gene

Aliases for ZFAND1 Gene

  • Zinc Finger AN1-Type Containing 1 2 3 5
  • Zinc Finger, AN1-Type Domain 1 2

External Ids for ZFAND1 Gene

Previous GeneCards Identifiers for ZFAND1 Gene

  • GC08M082777
  • GC08M082613
  • GC08M078103

Summaries for ZFAND1 Gene

GeneCards Summary for ZFAND1 Gene

ZFAND1 (Zinc Finger AN1-Type Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFAND1 Gene

Genomics for ZFAND1 Gene

Regulatory Elements for ZFAND1 Gene

Enhancers for ZFAND1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F081840 1.1 ENCODE 23.3 -109.2 -109206 2.5 PKNOX1 CREB3L1 ARID4B SIN3A ZNF143 SP3 NFYC ZHX2 REST TBX21 SNX16 HNRNPA1P36 ZFAND1 ENSG00000254689 CHMP4C LOC105375928
GH08F081279 1 ENCODE 17.1 +451.7 451673 2.7 HDGF ZNF133 ARID4B SIN3A GLI4 DMAP1 ZNF48 ZNF2 GLIS2 KLF7 ZFAND1 ENSG00000253859 LOC105375929 LOC100216346 ENSG00000254027 FABP5
GH08F081692 0.8 ENCODE 19.2 +38.5 38499 3.1 SOX13 ELF3 ZNF792 SAP130 ARID4B ZNF644 YY1 GATA3 HNF4G TCF7L2 IMPA1 CHMP4C ZFAND1 SLC10A5
GH08F081780 1 Ensembl ENCODE 11.2 -47.9 -47858 0.7 CTCF CBX3 RAD21 ZNF316 GATA3 ZNF143 ZNF207 SMC3 RCOR1 MAFK SNX16 CHMP4C ZFAND1 ENSG00000253334
GH08F081630 1 Ensembl ENCODE 9.5 +100.1 100090 5.3 CTCF ESRRA CEBPG POLR2A MAFK TCF7L2 MAZ NRF1 NR2F1 CEBPB IMPA1 ZFAND1 CHMP4C IMPA1P1 SLC10A5P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZFAND1 on UCSC Golden Path with GeneCards custom track

Promoters for ZFAND1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001395276 1003 3000 PKNOX1 ATF1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF121 GLIS2 KLF7

Genomic Location for ZFAND1 Gene

Chromosome:
8
Start:
81,701,331 bp from pter
End:
81,732,903 bp from pter
Size:
31,573 bases
Orientation:
Minus strand

Genomic View for ZFAND1 Gene

Genes around ZFAND1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFAND1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFAND1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFAND1 Gene

Proteins for ZFAND1 Gene

  • Protein details for ZFAND1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCF1-ZFAN1_HUMAN
    Recommended name:
    AN1-type zinc finger protein 1
    Protein Accession:
    Q8TCF1
    Secondary Accessions:
    • E5RIG0
    • E5RJ99
    • Q658R7
    • Q6IA32
    • Q6PGQ6
    • Q9H810

    Protein attributes for ZFAND1 Gene

    Size:
    268 amino acids
    Molecular mass:
    30787 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZFAND1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFAND1 Gene

Post-translational modifications for ZFAND1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZFAND1 Gene

Domains & Families for ZFAND1 Gene

Gene Families for ZFAND1 Gene

Protein Domains for ZFAND1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZFAND1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TCF1

UniProtKB/Swiss-Prot:

ZFAN1_HUMAN :
  • Contains 2 AN1-type zinc fingers.
Similarity:
  • Contains 2 AN1-type zinc fingers.
genes like me logo Genes that share domains with ZFAND1: view

Function for ZFAND1 Gene

Gene Ontology (GO) - Molecular Function for ZFAND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFAND1: view

Phenotypes for ZFAND1 Gene

GenomeRNAi human phenotypes for ZFAND1:
genes like me logo Genes that share phenotypes with ZFAND1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFAND1 Gene

Localization for ZFAND1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFAND1 gene
Compartment Confidence
nucleus 3
cytosol 3
extracellular 2
cytoskeleton 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZFAND1 Gene

Pathways & Interactions for ZFAND1 Gene

SuperPathways for ZFAND1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFAND1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZFAND1 Gene

Transcripts for ZFAND1 Gene

Unigene Clusters for ZFAND1 Gene

Zinc finger, AN1-type domain 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g · 9h
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - -
SP4: -
SP5: - -
SP6: - -
SP7: - - - - -
SP8: - - - -
SP9: - - -
SP10: -
SP11: -

Relevant External Links for ZFAND1 Gene

GeneLoc Exon Structure for
ZFAND1
ECgene alternative splicing isoforms for
ZFAND1

Expression for ZFAND1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZFAND1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZFAND1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.7), Lymph node (15.4), and Uterus (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZFAND1 Gene



Protein tissue co-expression partners for ZFAND1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZFAND1 Gene:

ZFAND1

SOURCE GeneReport for Unigene cluster for ZFAND1 Gene:

Hs.655453
genes like me logo Genes that share expression patterns with ZFAND1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZFAND1 Gene

Orthologs for ZFAND1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZFAND1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFAND1 34
  • 99.38 (n)
IMPA1 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZFAND1 34 35
  • 91.79 (n)
cow
(Bos Taurus)
Mammalia ZFAND1 35
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfand1 34 16 35
  • 84.2 (n)
rat
(Rattus norvegicus)
Mammalia Zfand1 34
  • 82.96 (n)
oppossum
(Monodelphis domestica)
Mammalia ZFAND1 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZFAND1 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZFAND1 34 35
  • 74.53 (n)
lizard
(Anolis carolinensis)
Reptilia ZFAND1 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zfand1 34
  • 67.04 (n)
Str.13002 34
zebrafish
(Danio rerio)
Actinopterygii zfand1 34 35
  • 61.42 (n)
Dr.19087 34
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YNL155W 34
  • 44.18 (n)
-- 35
  • 22 (a)
OneToOne
CUZ1 37
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D10978g 34
  • 40.59 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR041C 34
  • 40.54 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06586 34
  • 42.51 (n)
Species where no ortholog for ZFAND1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFAND1 Gene

ENSEMBL:
Gene Tree for ZFAND1 (if available)
TreeFam:
Gene Tree for ZFAND1 (if available)

Paralogs for ZFAND1 Gene

Pseudogenes.org Pseudogenes for ZFAND1 Gene

genes like me logo Genes that share paralogs with ZFAND1: view

No data available for Paralogs for ZFAND1 Gene

Variants for ZFAND1 Gene

Sequence variations from dbSNP and Humsavar for ZFAND1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1052497 -- 81,701,996(-) TTTTT(G/T)TTTGT nc-transcript-variant, utr-variant-3-prime
rs111276734 -- 81,717,456(+) ATCTA(-/TA)GTCTC intron-variant
rs111281207 -- 81,703,611(+) AGAGA(C/T)GGGCT intron-variant
rs111349763 -- 81,701,169(+) AGAAG(-/AGTC)AATCA downstream-variant-500B
rs111514086 -- 81,714,643(+) CAGGT(A/G)GACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFAND1 Gene

Variant ID Type Subtype PubMed ID
nsv831369 CNV gain+loss 17160897
nsv611607 CNV gain 21841781
nsv465721 CNV gain 19166990
esv3617801 CNV loss 21293372
esv3543740 CNV deletion 23714750
esv2606227 CNV deletion 19546169

Variation tolerance for ZFAND1 Gene

Residual Variation Intolerance Score: 50.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFAND1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFAND1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFAND1 Gene

Disorders for ZFAND1 Gene

Relevant External Links for ZFAND1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFAND1

No disorders were found for ZFAND1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFAND1 Gene

Publications for ZFAND1 Gene

  1. A conserved protein with AN1 zinc finger and ubiquitin-like domains modulates Cdc48 (p97) function in the ubiquitin-proteasome pathway. (PMID: 24121501) SA!-Moura B. … Hochstrasser M. (J. Biol. Chem. 2013) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. (PMID: 23535730) Pharoah P.D. … Sellers T.A. (Nat. Genet. 2013) 3 64
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64

Products for ZFAND1 Gene

Sources for ZFAND1 Gene

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