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Aliases for ZFAND1 Gene

Aliases for ZFAND1 Gene

  • Zinc Finger, AN1-Type Domain 1 2 3

External Ids for ZFAND1 Gene

Previous GeneCards Identifiers for ZFAND1 Gene

  • GC08M082777
  • GC08M082613
  • GC08M078103

Summaries for ZFAND1 Gene

GeneCards Summary for ZFAND1 Gene

ZFAND1 (Zinc Finger, AN1-Type Domain 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFAND1 Gene

Genomics for ZFAND1 Gene

Regulatory Elements for ZFAND1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZFAND1 Gene

81,701,331 bp from pter
81,732,903 bp from pter
31,573 bases
Minus strand

Genomic View for ZFAND1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZFAND1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFAND1 Gene

Proteins for ZFAND1 Gene

  • Protein details for ZFAND1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    AN1-type zinc finger protein 1
    Protein Accession:
    Secondary Accessions:
    • E5RIG0
    • E5RJ99
    • Q658R7
    • Q6IA32
    • Q6PGQ6
    • Q9H810

    Protein attributes for ZFAND1 Gene

    268 amino acids
    Molecular mass:
    30787 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZFAND1 Gene


neXtProt entry for ZFAND1 Gene

Proteomics data for ZFAND1 Gene at MOPED

Post-translational modifications for ZFAND1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZFAND1 Gene

Domains & Families for ZFAND1 Gene

Gene Families for ZFAND1 Gene

Protein Domains for ZFAND1 Gene


Suggested Antigen Peptide Sequences for ZFAND1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 AN1-type zinc fingers.
  • Contains 2 AN1-type zinc fingers.
genes like me logo Genes that share domains with ZFAND1: view

Function for ZFAND1 Gene

Gene Ontology (GO) - Molecular Function for ZFAND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ZFAND1: view

Phenotypes for ZFAND1 Gene

GenomeRNAi human phenotypes for ZFAND1:
genes like me logo Genes that share phenotypes with ZFAND1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZFAND1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFAND1 Gene

Localization for ZFAND1 Gene

Subcellular locations from

Jensen Localization Image for ZFAND1 Gene COMPARTMENTS Subcellular localization image for ZFAND1 gene
Compartment Confidence
cytoskeleton 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZFAND1 Gene

Pathways & Interactions for ZFAND1 Gene

SuperPathways for ZFAND1 Gene

No Data Available

Interacting Proteins for ZFAND1 Gene

Gene Ontology (GO) - Biological Process for ZFAND1 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZFAND1 Gene

Drugs & Compounds for ZFAND1 Gene

No Compound Related Data Available

Transcripts for ZFAND1 Gene

Unigene Clusters for ZFAND1 Gene

Zinc finger, AN1-type domain 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZFAND1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g · 9h
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - -
SP4: -
SP5: - -
SP6: - -
SP7: - - - - -
SP8: - - - -
SP9: - - -
SP10: -
SP11: -

Relevant External Links for ZFAND1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZFAND1 Gene

mRNA expression in normal human tissues for ZFAND1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZFAND1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.7), Lymph node (15.4), and Uterus (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZFAND1 Gene

SOURCE GeneReport for Unigene cluster for ZFAND1 Gene Hs.655453

genes like me logo Genes that share expression patterns with ZFAND1: view

Protein tissue co-expression partners for ZFAND1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZFAND1 Gene

Orthologs for ZFAND1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZFAND1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia ZFAND1 35
  • 91.79 (n)
  • 90.67 (a)
  • 90 (a)
(Mus musculus)
Mammalia Zfand1 35
  • 84.2 (n)
  • 82.84 (a)
Zfand1 16
Zfand1 36
  • 82 (a)
(Pan troglodytes)
Mammalia ZFAND1 35
  • 99.38 (n)
  • 99.25 (a)
IMPA1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Zfand1 35
  • 82.96 (n)
  • 83.96 (a)
(Bos Taurus)
Mammalia ZFAND1 36
  • 85 (a)
(Monodelphis domestica)
Mammalia ZFAND1 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia ZFAND1 36
  • 74 (a)
(Gallus gallus)
Aves ZFAND1 35
  • 74.53 (n)
  • 73.78 (a)
  • 72 (a)
(Anolis carolinensis)
Reptilia ZFAND1 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.13002 35
zfand1 35
  • 67.04 (n)
  • 69.29 (a)
(Danio rerio)
Actinopterygii Dr.19087 35
zfand1 35
  • 61.42 (n)
  • 61.42 (a)
zfand1 36
  • 60 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR041C 35
  • 40.54 (n)
  • 29.81 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D10978g 35
  • 40.59 (n)
  • 29.7 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YNL155W 35
  • 44.18 (n)
  • 31.13 (a)
-- 36
  • 22 (a)
-- 38
bread mold
(Neurospora crassa)
Ascomycetes NCU06586 35
  • 42.51 (n)
  • 36.44 (a)
Species with no ortholog for ZFAND1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFAND1 Gene

Gene Tree for ZFAND1 (if available)
Gene Tree for ZFAND1 (if available)

Paralogs for ZFAND1 Gene Pseudogenes for ZFAND1 Gene

genes like me logo Genes that share paralogs with ZFAND1: view

No data available for Paralogs for ZFAND1 Gene

Variants for ZFAND1 Gene

Sequence variations from dbSNP and Humsavar for ZFAND1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1052497 -- 81,701,996(-) TTTTT(G/T)TTTGT utr-variant-3-prime, nc-transcript-variant
rs2046786 -- 81,709,546(-) ACATA(A/C)ATGAA intron-variant
rs2046787 -- 81,709,428(-) TTTCT(A/G)TATAC intron-variant
rs2130263 -- 81,721,217(+) AAGCT(C/G/T)CCGGA intron-variant
rs2306917 -- 81,717,905(+) TGGAT(C/T)TTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFAND1 Gene

Variant ID Type Subtype PubMed ID
nsv465721 CNV Gain 19166990
nsv831369 CNV Gain+Loss 17160897
esv2606227 CNV Deletion 19546169

Variation tolerance for ZFAND1 Gene

Residual Variation Intolerance Score: 50.26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFAND1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFAND1 Gene

Disorders for ZFAND1 Gene

Relevant External Links for ZFAND1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZFAND1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFAND1 Gene

Publications for ZFAND1 Gene

  1. A conserved protein with AN1 zinc finger and ubiquitin-like domains modulates Cdc48 (p97) function in the ubiquitin-proteasome pathway. (PMID: 24121501) SA!-Moura B. … Hochstrasser M. (J. Biol. Chem. 2013) 2 67
  2. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. (PMID: 23535730) Pharoah P.D. … Sellers T.A. (Nat. Genet. 2013) 67
  3. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 67
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 67
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 67

Products for ZFAND1 Gene

Sources for ZFAND1 Gene

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