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ZFAND1 Gene

protein-coding   GIFtS: 45
GCID: GC08M082613

Zinc Finger, AN1-Type Domain 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger, AN1-Type Domain 11 2
AN1-Type Zinc Finger Protein 12

External Ids:    HGNC: 258581   Entrez Gene: 797522   Ensembl: ENSG000001042317   UniProtKB: Q8TCF13   
ORGUL members:         

Export aliases for ZFAND1 gene to outside databases

Previous GC identifers: GC08M082777 GC08M078103


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZFAND1 Gene:
ZFAND1 (zinc finger, AN1-type domain 1) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008183.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZFAND1 gene promoter:
         STAT5B   STAT1   STAT4   STAT6   STAT1beta   STAT1alpha   HNF-1A   HNF-1   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZFAND1 promoter sequence
   Search Chromatin IP Primers for ZFAND1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZFAND1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.13   Ensembl cytogenetic band:  8q21.13   HGNC cytogenetic band: 8q21.13

ZFAND1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFAND1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M082613:  view genomic region     (about GC identifiers)

Start:
82,613,566 bp from pter      End:
82,645,138 bp from pter
Size:
31,573 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for ZFAND1

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZFAN1_HUMAN, Q8TCF1 (See protein sequence)
Recommended Name: AN1-type zinc finger protein 1  
Size: 268 amino acids; 30787 Da
Secondary accessions: E5RIG0 Q658R7 Q6IA32 Q6PGQ6 Q9H810
Alternative splicing: 3 isoforms:  Q8TCF1-1   Q8TCF1-2   Q8TCF1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZFAND1: NX_Q8TCF1

Explore proteomics data for ZFAND1 at MOPED


See ZFAND1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_001164267.1  NP_001164268.1  NP_078975.2  

ENSEMBL proteins: 
 ENSP00000430736   ENSP00000220669   ENSP00000429999   ENSP00000430499   ENSP00000428375  
 ENSP00000429527   ENSP00000428139   ENSP00000428927   ENSP00000428278   ENSP00000430214  
 ENSP00000429167   ENSP00000428101   ENSP00000427957   ENSP00000427811   ENSP00000430405  
 ENSP00000428527   ENSP00000430719  

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Cloud-Clone Corp. Proteins for ZFAND1

 
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antibodies-online proteins for ZFAND1 (3 products) 

 
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antibodies-online kits for ZFAND1 (4 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ZFAND: Zinc fingers, AN1-type domain containing

1 InterPro protein domain:
 IPR000058 Znf_AN1

Graphical View of Domain Structure for InterPro Entry Q8TCF1

ProtoNet protein and cluster: Q8TCF1

UniProtKB/Swiss-Prot: ZFAN1_HUMAN, Q8TCF1
Similarity: Contains 2 AN1-type zinc fingers


Find genes that share domains with ZFAND1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008270zinc ion binding IEA--
     
Find genes that share ontologies with ZFAND1           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for ZFAND1:
 Cells with protrusions 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZFAND1
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miRNA
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miRTarBase miRNAs that target ZFAND1:
hsa-mir-125a-5p (MIRT021302)

Block miRNA regulation of human, mouse, rat ZFAND1 using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate ZFAND1:
hsa-miR-374a* hsa-miR-136 hsa-miR-361-5p
SwitchGear 3'UTR luciferase reporter plasmidZFAND1 3' UTR sequence
Inhib. RNA
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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
cytosol2
extracellular2
cytoskeleton1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZFAND1
Interactions:

    Search GeneGlobe Interaction Network for ZFAND1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for ZFAND1 (ENSP000002206694) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
InteractantInteraction Details
GeneCardExternal ID(s)
VCPENSP000003517774STRING: ENSP00000351777
MRM1ENSP000002501564STRING: ENSP00000250156
NPLOC4ENSP000003314874STRING: ENSP00000331487
NSFL1CENSP000002168794STRING: ENSP00000216879
UBXN2BENSP000003825074STRING: ENSP00000382507
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ZFAND1 (ZFAN1)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ZFAND1 gene (3 alternative transcripts): 
NM_001170796.1  NM_001170797.1  NM_024699.2  

Unigene Cluster for ZFAND1:

Zinc finger, AN1-type domain 1
Hs.655453  [show with all ESTs]
Unigene Representative Sequence: NR_033193
Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
ENST00000524305(uc010lzx.2 uc003ycj.2 uc022awt.1 uc022awu.1 uc003yck.2)
ENST00000523096 ENST00000220669 ENST00000522520 ENST00000519338 ENST00000522032
ENST00000519464 ENST00000521895 ENST00000521287 ENST00000523431 ENST00000520635
ENST00000517588 ENST00000519523(uc022awv.1 uc022aww.1) ENST00000520604
ENST00000523361 ENST00000517450 ENST00000521742 ENST00000518419
miRNA
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3 qRT-PCR Assays for microRNAs that regulate ZFAND1:
hsa-miR-374a* hsa-miR-136 hsa-miR-361-5p
SwitchGear 3'UTR luciferase reporter plasmidZFAND1 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for ZFAND1
Predesigned siRNA for gene silencing in human, mouse, rat ZFAND1
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OriGene ORF clones in mouse, rat for ZFAND1
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GenScript: all cDNA clones in your preferred vector (see all 3): ZFAND1 (NM_024699)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZFAND1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFAND1
Primer
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZFAND1
  QuantiTect SYBR Green Assays in human, mouse, rat ZFAND1
  QuantiFast Probe-based Assays in human, mouse, rat ZFAND1

Additional mRNA sequence: 

AK024069.1 AK225195.1 AK304111.1 BC022251.2 BC051857.1 BC056877.1 CR457323.1 NR_033193.1 
NR_033194.1 NR_033195.1 NR_033196.1 

19 DOTS entries:

DT.100654487  DT.409315  DT.100870821  DT.121485419  DT.100654488  DT.97815093  DT.121485414  DT.109798 
DT.303261  DT.91927156  DT.95115129  DT.100654492  DT.100857388  DT.102831583  DT.121485475  DT.121485490 
DT.91725491  DT.99999485  DT.99995180 

Selected AceView cDNA sequences (see all 150):

AI968003 AA844090 CA412820 CR593847 CA336883 BQ428039 AL833030 CD108172 
AW673167 BU159374 AI051779 BQ427843 BG286221 AI523843 AA452520 BP367092 
AI829581 BE018789 AA875951 BX281019 AA454103 BC051857 AW651706 CR625306 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND1 (see all 11)    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g · 9h
SP1:                                            -           -     -                 -                 -     -                                             
SP2:                                -           -           -     -                 -                 -     -                                             
SP3:                    -           -           -           -     -                 -                 -     -     -                                       
SP4:                                            -                                                                                                         
SP5:                                                                                                  -     -                                             


ECgene alternative splicing isoforms for ZFAND1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZFAND1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
ZFAND1 Expression
About this image

ZFAND1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ZFAND1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.655453
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFAND1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for ZFAND1 gene from Selected species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Zfand11 , 5 zinc finger, AN1-type domain 11, 5 84.2(n)1
82.84(a)1
  3 (2.62 cM)5
663611  NM_025512.21  NP_079788.21 
 103399535 
chicken
(Gallus gallus)
Aves ZFAND11 zinc finger, AN1-type domain 1 74.53(n)
73.78(a)
  420200  XM_418311.4  XP_418311.3 
lizard
(Anolis carolinensis)
Reptilia ZFAND16
zinc finger, AN1-type domain 1
74(a)
1 ↔ 1
4(24422463-24431310)
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.130022 Transcribed sequence with weak similarity to protein more 76.23(n)    BX723955.1 
zebrafish
(Danio rerio)
Actinopterygii Dr.190872 Transcribed sequence with weak similarity to protein more 73.9(n)    BQ617732.1 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes (YNL155W)4
YNL155W1
Putative protein of unknown function; contains a DHHC more4
YNL155W1
44.18(n)1
31.13(a)1
  14(342516-343340)4
8555671, 4  NP_014244.11, 4 


ENSEMBL Gene Tree for ZFAND1 (if available)
TreeFam Gene Tree for ZFAND1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ZFAND1 gene
1 SIMAP similar gene for ZFAND1 using alignment to 14 protein entries:     ZFAN1_HUMAN (see all proteins):
ZFAND2B

Find genes that share paralogs with ZFAND1           About GenesLikeMe


4 Pseudogenes.org Pseudogenes for ZFAND1
PGOHUM00000256879 PGOHUM00000256880 PGOHUM00000245095 PGOHUM00000257076


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZFAND1 (see all 491)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1884539601,2
--82613130(+) GATCAC/TACCAC 5 -- int10--------
rs1113497631,2
C--82613404(+) AGAAG-/AGTC  
        
AATCA
5 -- int11Minor allele frequency- AGTC:0.50CSA 2
rs29322231,2
C,F,H--82613459(+) ACAGCC/TACCCC 5 -- int119Minor allele frequency- T:0.39NS EA NA CSA WA 2322
rs1916183221,2
--82613541(+) CATTAC/TAAATT 5 -- int10--------
rs757155411,2
F--82613555(+) GAAGGC/TTCAGA 5 -- int11Minor allele frequency- T:0.02EA 120
rs357883511,2
C--82613690(+) AAAAA-/A/GTTTGT 10 -- ut31 nc-transcript-variant0--------
rs1844308361,2
--82613862(+) ATGCTA/GATGAA 5 -- ut31 nc-transcript-variant0--------
rs29550151,2
C,F,A,H--82614003(-) ACATAT/GGTAGT 5 -- ut31 nc-transcript-variantese325Minor allele frequency- G:0.26NA NS EA 2498
rs1874478031,2
--82614040(+) AAAAGA/GACAAA 5 -- ut31 nc-transcript-variant0--------
rs1919354671,2
--82614070(+) GTCTAG/TATAGT 5 -- ut31 nc-transcript-variant0--------

HapMap Linkage Disequilibrium report for ZFAND1 (82613566 - 82645138 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for ZFAND1:    About this table    
Variant IDTypeSubtypePubMed ID
esv2606227CNV Deletion19546169
nsv465721CNV Gain19166990
nsv831369CNV Gain+Loss17160897

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing ZFAND1
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ZFAND1 gene, integrated from 10 sources (see all 11):
(articles sorted by number of sources associating them with ZFAND1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  4. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. (PubMed id 23535730)1 Pharoah P.D....Sellers T.A. (Nat. Genet. 2013)
  5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
  6. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
  7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
  8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
  9. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (Nature 2006)
  10. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 79752 HGNC: 25858 AceView: FLJ14007 Ensembl:ENSG00000104231 euGenes: HUgn79752
ECgene: ZFAND1 H-InvDB: ZFAND1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ZFAND1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ZFAND1 gene:
Search GeneIP for patents involving ZFAND1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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