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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZFAND1 Gene

protein-coding   GIFtS: 43
GCID: GC08M082613

Zinc Finger, AN1-Type Domain 1

  Search for ZFAND1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger, AN1-Type Domain 11 2
AN1-Type Zinc Finger Protein 12

External Ids:    HGNC: 258581   Entrez Gene: 797522   Ensembl: ENSG000001042317   UniProtKB: Q8TCF13   
ORGUL members:         
NONCODE14:n409092 n409089      

Export aliases for ZFAND1 gene to outside databases

Previous GC identifers: GC08M082777 GC08M078103


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZFAND1 Gene: 
ZFAND1 (zinc finger, AN1-type domain 1) is a protein-coding gene, and is affiliated with the lncRNA class. GO annotations related to this gene include zinc ion binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_008183.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZFAND1 gene promoter:
         STAT5B   STAT1   STAT4   STAT6   STAT1beta   STAT1alpha   HNF-1A   HNF-1   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZFAND1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZFAND1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFAND1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.13   Ensembl cytogenetic band:  8q21.13   HGNC cytogenetic band: 8q21.13

ZFAND1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFAND1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M082613:  view genomic region     (about GC identifiers)

Start:
82,613,566 bp from pter      End:
82,645,138 bp from pter
Size:
31,573 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for ZFAND1

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZFAN1_HUMAN, Q8TCF1 (See protein sequence)
Recommended Name: AN1-type zinc finger protein 1  
Size: 268 amino acids; 30787 Da
Secondary accessions: E5RIG0 Q658R7 Q6IA32 Q6PGQ6 Q9H810
Alternative splicing: 3 isoforms:  Q8TCF1-1   Q8TCF1-2   Q8TCF1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZFAND1: NX_Q8TCF1

Explore proteomics data for ZFAND1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TCF1

  • ZFAND1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZFAND1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001164267.1  NP_001164268.1  NP_078975.2  

    ENSEMBL proteins: 
     ENSP00000430736   ENSP00000220669   ENSP00000429999   ENSP00000430499   ENSP00000428375  
     ENSP00000429527   ENSP00000428139   ENSP00000428927   ENSP00000428278   ENSP00000430214  
     ENSP00000429167   ENSP00000428101   ENSP00000427957   ENSP00000427811   ENSP00000430405  
     ENSP00000428527   ENSP00000430719  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZFAND: Zinc fingers, AN1-type domain containing

    1 InterPro protein domain:
     IPR000058 Znf_AN1

    Graphical View of Domain Structure for InterPro Entry Q8TCF1

    ProtoNet protein and cluster: Q8TCF1

    UniProtKB/Swiss-Prot: ZFAN1_HUMAN, Q8TCF1
    Similarity: Contains 2 AN1-type zinc fingers


    ZFAND1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
         
    ZFAND1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZFAND1:
     Cells with protrusions 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidZFAND1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZFAND1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for ZFAND1 (ENSP000002206694) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC2ENSP000003813314STRING: ENSP00000381331
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    NPLOC4ENSP000003314874STRING: ENSP00000331487
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZFAND1 (ZFAN1)

    Search CenterWatch for drugs/clinical trials and news about ZFAND1 / ZFAN1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZFAND1 gene (3 alternative transcripts): 
    NM_001170796.1  NM_001170797.1  NM_024699.2  

    Unigene Cluster for ZFAND1:

    Zinc finger, AN1-type domain 1
    Hs.655453  [show with all ESTs]
    Unigene Representative Sequence: NR_033193
    18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000524305(uc010lzx.2 uc003ycj.2 uc022awt.1 uc022awu.1 uc003yck.2)
    ENST00000523096 ENST00000220669 ENST00000522520 ENST00000519338 ENST00000522032
    ENST00000519464 ENST00000521895 ENST00000521287 ENST00000523431 ENST00000520635
    ENST00000517588 ENST00000519523(uc022awv.1 uc022aww.1) ENST00000520604
    ENST00000523361 ENST00000517450 ENST00000521742 ENST00000518419
    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate ZFAND1:
    hsa-miR-374a* hsa-miR-136 hsa-miR-361-5p
    SwitchGear 3'UTR luciferase reporter plasmidZFAND1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK024069.1 AK225195.1 AK304111.1 BC022251.2 BC051857.1 BC056877.1 CR457323.1 NR_033193.1 
    NR_033194.1 NR_033195.1 NR_033196.1 

    19 DOTS entries:

    DT.100654487  DT.409315  DT.100870821  DT.121485419  DT.100654488  DT.97815093  DT.121485414  DT.109798 
    DT.303261  DT.91927156  DT.95115129  DT.100654492  DT.100857388  DT.102831583  DT.121485475  DT.121485490 
    DT.91725491  DT.99999485  DT.99995180 

    24/150 AceView cDNA sequences (see all 150):

    AA844090 AA875951 BQ720433 AW651706 CA336883 BP367092 AW673167 BP345698 
    BX281019 AI767012 CB136018 BG929103 CD108172 BU158663 BU159374 AL709159 
    AI523843 AI829581 BG286221 CA412820 AA452520 BU159985 AA460225 BQ428039 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND1 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g · 9h
    SP1:                                            -           -     -                 -                 -     -                                             
    SP2:                                -           -           -     -                 -                 -     -                                             
    SP3:                    -           -           -           -     -                 -                 -     -     -                                       
    SP4:                                            -                                                                                                         
    SP5:                                                                                                  -     -                                             


    ECgene alternative splicing isoforms for ZFAND1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZFAND1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZFAND1 Expression
    About this image


    See ZFAND1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZFAND1

    SOURCE GeneReport for Unigene cluster: Hs.655453
        SABiosciences Custom PCR Arrays for ZFAND1
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ZFAND1 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfand11 , 5 zinc finger, AN1-type domain 11, 5 84.2(n)1
    82.84(a)1
      3 (2.62 cM)5
    663611  NM_025512.21  NP_079788.21 
     103399535 
    chicken
    (Gallus gallus)
    Aves ZFAND11 zinc finger, AN1-type domain 1 74.28(n)
    73.78(a)
      420200  XM_418311.3  XP_418311.3 
    lizard
    (Anolis carolinensis)
    Reptilia ZFAND16
    Uncharacterized protein
    74(a)
    1 ↔ 1
    4(24422463-24431310)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.130022 Transcribed sequence with weak similarity to protein more 76.23(n)    BX723955.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.190872 Transcribed sequence with weak similarity to protein more 73.9(n)    BQ617732.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YNL155W)4
    YNL155W1
    Putative protein of unknown function; contains a DHHC more4
    hypothetical protein1
    44.39(n)1
    31.73(a)1
      14(342516-343340)4
    8555671, 4  NP_014244.11, 4 


    ENSEMBL Gene Tree for ZFAND1 (if available)
    TreeFam Gene Tree for ZFAND1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZFAND1 gene
    1 SIMAP similar gene for ZFAND1 using alignment to 14 protein entries:     ZFAN1_HUMAN (see all proteins):
    ZFAND2B

    ZFAND1 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for ZFAND1
    PGOHUM00000256879 PGOHUM00000256880 PGOHUM00000245095 PGOHUM00000257076


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/491 SNPs in ZFAND1 are shown (see all 491)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1884539601,2
    --82613130(+) GATCAC/TACCAC 5 -- int10--------
    rs1113497631,2
    C--82613404(+) AGAAG-/AGTC  
            
    AATCA
    5 -- int11Minor allele frequency- AGTC:0.50CSA 2
    rs29322231,2
    C,F,H--82613459(+) ACAGCC/TACCCC 5 -- int119Minor allele frequency- T:0.39NS EA NA CSA WA 2322
    rs1916183221,2
    --82613541(+) CATTAC/TAAATT 5 -- int10--------
    rs757155411,2
    F--82613555(+) GAAGGC/TTCAGA 5 -- int11Minor allele frequency- T:0.02EA 120
    rs357883511,2
    C--82613690(+) AAAAA-/A/GTTTGT 10 -- ut31 nc-transcript-variant0--------
    rs1844308361,2
    --82613862(+) ATGCTA/GATGAA 5 -- ut31 nc-transcript-variant0--------
    rs29550151,2
    C,F,A,H--82614003(-) ACATAT/GGTAGT 5 -- ut31 nc-transcript-variantese325Minor allele frequency- G:0.26NA NS EA 2498
    rs1874478031,2
    --82614040(+) AAAAGA/GACAAA 5 -- ut31 nc-transcript-variant0--------
    rs1919354671,2
    --82614070(+) GTCTAG/TATAGT 5 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for ZFAND1 (82613566 - 82645138 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZFAND1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2606227CNV Deletion19546169
    nsv465721CNV Gain19166990
    nsv831369CNV Gain+Loss17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZFAND1 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with ZFAND1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. GWAS meta-analysis and replication identifies three ne w susceptibility loci for ovarian cancer. (PubMed id 23535730)1 Pharoah P.D....Sellers T.A. (2013)
    5. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79752 HGNC: 25858 AceView: FLJ14007 Ensembl:ENSG00000104231 euGenes: HUgn79752
    ECgene: ZFAND1 H-InvDB: ZFAND1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZFAND1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZFAND1 gene:
    Search GeneIP for patents involving ZFAND1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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