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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZER1 Gene

protein-coding   GIFtS: 49
GCID: GC09M131492

Zyg-11 Related, Cell Cycle Regulator

(Previous names: chromosome 9 open reading frame 60, zyg-11 homolog B (C....)
(Previous symbols: C9orf60, ZYG11BL)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zyg-11 Related, Cell Cycle Regulator1 2     Zer-1 Homolog (C. Elegans)1
C9orf601 2 3     Zyg-11 Homolog B (C. Elegans)-Like1
ZYG11BL1 2 3     Protein Zer-1 Homolog2
Zyg-11 Homolog B-Like Protein2 3     Zer-1 Homolog2
ZYG2 3     ZYG Homolog2
Chromosome 9 Open Reading Frame 601     Hzyg3

External Ids:    HGNC: 309601   Entrez Gene: 104442   Ensembl: ENSG000001604457   UniProtKB: Q7Z7L73   

Export aliases for ZER1 gene to outside databases

Previous GC identifers: GC09M130532 GC09M101101


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZER1 Gene:
This gene encodes a subunit of an E3 ubiquitin ligase complex that may be involved in meiosis. The encoded protein
contains three leucine-rich repeat motifs. (provided by RefSeq, Nov 2012)

GeneCards Summary for ZER1 Gene: 
ZER1 (zyg-11 related, cell cycle regulator) is a protein-coding gene. Diseases associated with ZER1 include prostatitis. GO annotations related to this gene include ubiquitin-protein ligase activity and proton-transporting ATPase activity, rotational mechanism. An important paralog of this gene is ZYG11B.

UniProtKB/Swiss-Prot: ZER1_HUMAN, Q7Z7L7
Function: Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZER1-CUL2-Elongin BC




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZER1 gene promoter:
         NF-YA   Tal-1beta   YY1   E47   NF-YB   CBF-A   CBF-B   HSF2   CP1A   NF-Y   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZER1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZER1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZER1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q33.3

ZER1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZER1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M131492:  view genomic region     (about GC identifiers)

Start:
131,492,065 bp from pter      End:
131,534,693 bp from pter
Size:
42,629 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZER1_HUMAN, Q7Z7L7 (See protein sequence)
Recommended Name: Protein zer-1 homolog  
Size: 766 amino acids; 88169 Da
Subunit: Interacts with the TCEB1-TCEB2/Elongin BC complex. Part of an E3 ubiquitin ligase complex including ZER1,
CUL2 and Elongin BC
Sequence caution: Sequence=CAI15408.1; Type=Erroneous gene model prediction; Sequence=CAI15409.1; Type=Erroneous
gene model prediction;
Secondary accessions: O00156 Q5T272 Q5T273

Explore the universe of human proteins at neXtProt for ZER1: NX_Q7Z7L7

Explore proteomics data for ZER1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7Z7L7

  • ZER1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZER1 Protein Expression
    REFSEQ proteins: NP_006327.2  
    ENSEMBL proteins: 
     ENSP00000291900   ENSP00000393051   ENSP00000389271  

    Human Recombinant Protein Products for ZER1: 
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    GenScript Custom Purified and Recombinant Proteins Services for ZER1
    Novus Biologicals ZER1 Protein
    Novus Biologicals ZER1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZER1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031462Cul2-RING ubiquitin ligase complex IDA17304241

    ZER1 for ontologies           About GeneDecksing



    ZER1 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for ZER1 
    Cloud-Clone Corp. CLIAs for ZER1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZYG11: ZYG11 cell cycle regulator family

    3 InterPro protein domains:
     IPR004908 ATPase_V1-cplx_hsu
     IPR011989 ARM-like
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q7Z7L7

    ProtoNet protein and cluster: Q7Z7L7

    1 Blocks protein domain: IPB000225 Armadillo repeat

    UniProtKB/Swiss-Prot: ZER1_HUMAN, Q7Z7L7
    Similarity: Belongs to the zyg-11 family
    Similarity: Contains 5 ARM repeats
    Similarity: Contains 3 LRR (leucine-rich) repeats


    ZER1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZER1_HUMAN, Q7Z7L7
    Function: Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZER1-CUL2-Elongin BC

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IMP17304241
    GO:0005488binding ----
    GO:0005515protein binding ----
         
    ZER1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZER1:
     Big cells  Decreased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZER1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZER1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZER1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZER1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZER1
    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate ZER1 (see all 58):
    hsa-miR-15a hsa-miR-503 hsa-miR-29a hsa-miR-485-3p hsa-miR-486-3p hsa-miR-374a hsa-miR-449a hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidZER1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZER1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZER1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/60 Interacting proteins for ZER1 (Q7Z7L72, 3 ENSP000002919004) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CUL2Q136172, 3, ENSP000003638804MINT-4507629 I2D: score=5 STRING: ENSP00000363880
    TCEB2Q153703, ENSP000002623064I2D: score=1 STRING: ENSP00000262306
    TCEB1Q153693, ENSP000002848114I2D: score=3 STRING: ENSP00000284811
    NUB1Q9Y5A73I2D: score=5 
    MLH1P406923I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IMP17304241
    GO:0051438regulation of ubiquitin-protein ligase activity IMP17304241

    ZER1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZER1

    Search CenterWatch for drugs/clinical trials and news about ZER1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZER1 gene: 
    NM_006336.3  

    Unigene Clusters for ZER1:

    Zyg-11 related, cell cycle regulator
    Hs.147950  [show with all ESTs], Hs.744180  [show with all ESTs]
    Unigene Representative Sequences: NM_006336, CF593553
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000291900(uc004bwa.1) ENST00000494461 ENST00000414921 ENST00000427848

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZER1
    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate ZER1 (see all 58):
    hsa-miR-15a hsa-miR-503 hsa-miR-29a hsa-miR-485-3p hsa-miR-486-3p hsa-miR-374a hsa-miR-449a hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidZER1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZER1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZER1
    Clone
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    OriGene clones in human, mouse for ZER1 (see all 7)
    OriGene ORF clones in mouse, rat for ZER1
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    GenScript: all cDNA clones in your preferred vector: ZER1 (NM_006336)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZER1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZER1
    Sirion Biotech Customized lentivirus for stable overexpression of ZER1 
                         Customized lentivirus expression plasmids for stable overexpression of ZER1 
    Primer
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    OriGene qPCR primer pairs and template standards for ZER1
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZER1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZER1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZER1

    Additional mRNA sequence: BC033884.1 

    9 DOTS entries:

    DT.80101775  DT.100755536  DT.100755537  DT.100755533  DT.121186159  DT.121186164  DT.91638420  DT.95357220 
    DT.99999888 

    24/318 AceView cDNA sequences (see all 318):

    AI150991 AI971634 BU785665 CR605088 AW044449 AW516927 BF115293 W76140 
    AI074493 BF438326 BU738000 BF447415 T09150 BM563165 BF726708 CA415223 
    BC001447 BM548944 AI187775 AI088570 AI688370 CD622437 AA431619 AW338555 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZER1 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18
    SP1:                                                                                                                                                      
    SP2:                                                                                                                                                      
    SP3:                                                                                                                                                      
    SP4:        -     -     -                                                                                                                                 
    SP5:              -     -                                                                                                                                 


    ECgene alternative splicing isoforms for ZER1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZER1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGCGCTCCC
    ZER1 Expression
    About this image


    See ZER1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZER1

    SOURCE GeneReport for Unigene clusters: Hs.147950 Hs.744180

    UniProtKB/Swiss-Prot: ZER1_HUMAN, Q7Z7L7
    Tissue specificity: Expressed in testis, spermatocytes and spermatids (at protein level). Expressed in
    spermatocytes, spermatids, prostate, skeletal muscle, ovary, small intestine, heart, brain and pancreas

        SABiosciences Expression via Pathway-Focused PCR Array including ZER1: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZER1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZER1 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zer11 , 5 zer-1 homolog (C. elegans)1, 5 89.25(n)1
    96.34(a)1
      2 (21.16 cM)5
    2276931  NM_178694.31  NP_848809.21 
     300972835 
    chicken
    (Gallus gallus)
    Aves ZER11 zer-1 homolog (C. elegans) 80.68(n)
    89.95(a)
      417205  XM_415488.3  XP_415488.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC690202 hypothetical protein MGC69020 77.65(n)    BC057742.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zer11 zer-1 homolog (C. elegans) 70.2(n)
    70.55(a)
      405837  NM_212901.1  NP_998066.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG120841 CG12084 52.02(n)
    40.94(a)
      192509  NM_138268.1  NP_612112.1 
    worm
    (Caenorhabditis elegans)
    Secernentea zer-11 Protein ZER-1 47.92(n)
    40.75(a)
      175249  NM_171079.6  NP_741090.3 


    ENSEMBL Gene Tree for ZER1 (if available)
    TreeFam Gene Tree for ZER1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZER1 gene
    ZYG11B2  ZYG11A2  

    ZER1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/850 SNPs in ZER1 are shown (see all 850)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1180716821,2
    C,F--131504285(+) TCCCTG/CGGTTT 1 -- ds50011Minor allele frequency- C:0.03EA 120
    rs1386812111,2
    --131504302(+) ACTCTA/GTCCTC 1 -- ds50010--------
    rs48373001,2
    C--131504402(+) CCTGAC/TCCGCC 1 -- ds500113Minor allele frequency- T:0.00NA WA CSA EA 375
    rs736699681,2
    C,F--131504486(+) CTTCTA/GTTTGC 1 -- ds50012Minor allele frequency- G:0.05WA 120
    rs1820560831,2
    --131504711(+) GCCAGC/GGGTGG 1 -- ds50010--------
    rs1142428121,2
    F--131505042(+) CCTGCC/GGTCCT 1 -- ut311Minor allele frequency- G:0.03WA 118
    rs736265691,2
    C--131505043(+) CTGCCG/ATCCTG 1 -- ut313Minor allele frequency- A:0.05WA NA EA 242
    rs1148398541,2
    C,F--131505163(+) CCCTGC/TGCTCC 1 -- ut311Minor allele frequency- T:0.13WA 118
    rs1494316911,2
    --131505270(+) GGACCA/GCCAGG 1 -- ut310--------
    rs48366221,2
    C,H--131505354(+) GGCTGG/TCATGG 1 -- ut31 ese315Minor allele frequency- T:0.01NS EA NA WA CSA 674

    HapMap Linkage Disequilibrium report for ZER1 (131492065 - 131534693 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZER1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv893901CNV Loss21882294
    dgv8296n71CNV Loss21882294
    nsv893902CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZER1
    DNA2.0 Custom Variant and Variant Library Synthesis for ZER1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for ZER1:    About MalaCards
    prostatitis    


    ZER1 for disorders           About GeneDecksing


    Export disorders for ZER1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZER1 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with ZER1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Meiotic human sperm cells express a leucine-rich homologue of Caenorhabditis elegans early embryogenesis gene, Zyg-11. (PubMed id 11719588)1, 2, 3, 9 Feral C.... Guellaen G. (2001)
    2. The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components. (PubMed id 17304241)1, 2 Vasudevan S.... Kipreos E.T. (2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    5. Genetic variants associated with disordered eating. (PubMed id 23568457)1 Wade T.D....Martin N.G. (2013)
    6. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10444 HGNC: 30960 AceView: C9orf60.1 Ensembl:ENSG00000160445 euGenes: HUgn10444
    ECgene: ZER1 H-InvDB: ZER1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZER1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZER1 gene:
    Search GeneIP for patents involving ZER1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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