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Aliases for ZER1 Gene

Aliases for ZER1 Gene

  • Zyg-11 Related Cell Cycle Regulator 2 3
  • Zyg-11 Related, Cell Cycle Regulator 3 5
  • Zyg-11 Homolog B-Like Protein 3 4
  • C9orf60 3 4
  • ZYG11BL 3 4
  • ZYG 3 4
  • Chromosome 9 Open Reading Frame 60 2
  • Zyg-11 Homolog B (C. Elegans)-Like 2
  • Zer-1 Homolog (C. Elegans) 2
  • Zer-1 Homolog 3
  • ZYG Homolog 3
  • Hzyg 4

External Ids for ZER1 Gene

Previous HGNC Symbols for ZER1 Gene

  • C9orf60
  • ZYG11BL

Previous GeneCards Identifiers for ZER1 Gene

  • GC09M130532
  • GC09M131492
  • GC09M101101

Summaries for ZER1 Gene

Entrez Gene Summary for ZER1 Gene

  • This gene encodes a subunit of an E3 ubiquitin ligase complex that may be involved in meiosis. The encoded protein contains three leucine-rich repeat motifs. [provided by RefSeq, Nov 2012]

GeneCards Summary for ZER1 Gene

ZER1 (Zyg-11 Related Cell Cycle Regulator) is a Protein Coding gene. GO annotations related to this gene include binding and ubiquitin-protein transferase activity. An important paralog of this gene is ZYG11A.

UniProtKB/Swiss-Prot for ZER1 Gene

  • Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZER1-CUL2-Elongin BC.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZER1 Gene

Genomics for ZER1 Gene

Regulatory Elements for ZER1 Gene

Promoters for ZER1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZER1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZER1 Gene

Chromosome:
9
Start:
128,729,786 bp from pter
End:
128,772,422 bp from pter
Size:
42,637 bases
Orientation:
Minus strand

Genomic View for ZER1 Gene

Genes around ZER1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZER1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZER1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZER1 Gene

Proteins for ZER1 Gene

  • Protein details for ZER1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7L7-ZER1_HUMAN
    Recommended name:
    Protein zer-1 homolog
    Protein Accession:
    Q7Z7L7
    Secondary Accessions:
    • O00156
    • Q5T272
    • Q5T273

    Protein attributes for ZER1 Gene

    Size:
    766 amino acids
    Molecular mass:
    88169 Da
    Quaternary structure:
    • Interacts with the TCEB1-TCEB2/Elongin BC complex. Part of an E3 ubiquitin ligase complex including ZER1, CUL2 and Elongin BC.
    SequenceCaution:
    • Sequence=CAI15408.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15409.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ZER1 Gene

Proteomics data for ZER1 Gene at MOPED

Post-translational modifications for ZER1 Gene

  • Ubiquitination at Lys 31, Lys 119, and Lys 323
  • Modification sites at PhosphoSitePlus

Other Protein References for ZER1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ZER1 Gene

Domains & Families for ZER1 Gene

Gene Families for ZER1 Gene

Protein Domains for ZER1 Gene

Suggested Antigen Peptide Sequences for ZER1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z7L7

UniProtKB/Swiss-Prot:

ZER1_HUMAN :
  • Belongs to the zyg-11 family.
  • Contains 5 ARM repeats.
Family:
  • Belongs to the zyg-11 family.
Similarity:
  • Contains 5 ARM repeats.
  • Contains 3 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with ZER1: view

Function for ZER1 Gene

Molecular function for ZER1 Gene

UniProtKB/Swiss-Prot Function:
Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZER1-CUL2-Elongin BC.

Gene Ontology (GO) - Molecular Function for ZER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IMP 17304241
genes like me logo Genes that share ontologies with ZER1: view
genes like me logo Genes that share phenotypes with ZER1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZER1 Gene

Localization for ZER1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZER1 Gene COMPARTMENTS Subcellular localization image for ZER1 gene
Compartment Confidence
cytoskeleton 3
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZER1 Gene

Pathways & Interactions for ZER1 Gene

SuperPathways for ZER1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IMP 17304241
genes like me logo Genes that share ontologies with ZER1: view

No data available for Pathways by source and SIGNOR curated interactions for ZER1 Gene

Drugs & Compounds for ZER1 Gene

No Compound Related Data Available

Transcripts for ZER1 Gene

Unigene Clusters for ZER1 Gene

Zyg-11 related, cell cycle regulator:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZER1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18
SP1:
SP2:
SP3:
SP4: - - -
SP5: - -
SP6: -

Relevant External Links for ZER1 Gene

GeneLoc Exon Structure for
ZER1
ECgene alternative splicing isoforms for
ZER1

Expression for ZER1 Gene

mRNA expression in normal human tissues for ZER1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZER1 Gene

This gene is overexpressed in Frontal cortex (10.1) and Salivary gland (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZER1 Gene



SOURCE GeneReport for Unigene cluster for ZER1 Gene Hs.147950

mRNA Expression by UniProt/SwissProt for ZER1 Gene

Q7Z7L7-ZER1_HUMAN
Tissue specificity: Expressed in testis, spermatocytes and spermatids (at protein level). Expressed in spermatocytes, spermatids, prostate, skeletal muscle, ovary, small intestine, heart, brain and pancreas.
genes like me logo Genes that share expression patterns with ZER1: view

Protein tissue co-expression partners for ZER1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ZER1 Gene

Orthologs for ZER1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZER1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZER1 36
  • 100 (a)
OneToOne
ZER1 35
  • 99.61 (n)
  • 99.87 (a)
cow
(Bos Taurus)
Mammalia ZER1 35
  • 92.34 (n)
  • 98.3 (a)
ZER1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZER1 36
  • 98 (a)
OneToOne
ZER1 35
  • 92.69 (n)
  • 98.04 (a)
mouse
(Mus musculus)
Mammalia Zer1 16
Zer1 36
  • 95 (a)
OneToOne
Zer1 35
  • 89.25 (n)
  • 96.34 (a)
oppossum
(Monodelphis domestica)
Mammalia ZER1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZER1 36
  • 40 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zer1 35
  • 89.38 (n)
  • 96.34 (a)
chicken
(Gallus gallus)
Aves ZER1 35
  • 80.68 (n)
  • 89.95 (a)
ZER1 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC69020 35
tropical clawed frog
(Silurana tropicalis)
Amphibia zer1 35
  • 75.48 (n)
  • 83.27 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6570 35
zebrafish
(Danio rerio)
Actinopterygii zer1 36
  • 66 (a)
OneToOne
zer1 35
  • 70.38 (n)
  • 70.68 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005961 35
  • 51.16 (n)
  • 39.66 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12084 36
  • 32 (a)
OneToOne
CG12084 35
  • 52.07 (n)
  • 40.94 (a)
worm
(Caenorhabditis elegans)
Secernentea zer-1 35
  • 48.11 (n)
  • 40.93 (a)
zer-1 36
  • 26 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
OneToOne
Species with no ortholog for ZER1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZER1 Gene

ENSEMBL:
Gene Tree for ZER1 (if available)
TreeFam:
Gene Tree for ZER1 (if available)

Paralogs for ZER1 Gene

Paralogs for ZER1 Gene

genes like me logo Genes that share paralogs with ZER1: view

Variants for ZER1 Gene

Sequence variations from dbSNP and Humsavar for ZER1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs13299702 - 128,741,801(+) TTACT(A/G)TCTTG reference, missense
rs1572917 -- 128,745,231(-) agaat(C/G)agaca intron-variant
rs2298044 -- 128,739,833(-) CACCT(C/T)CCTTC intron-variant
rs3831329 -- 128,753,035(-) AGACA(-/CA)GTCCC intron-variant
rs2017516 -- 128,752,628(-) tcaac(A/C)ggcat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZER1 Gene

Variant ID Type Subtype PubMed ID
nsv893901 CNV Loss 21882294
nsv893902 CNV Gain 21882294
dgv8296n71 CNV Loss 21882294

Variation tolerance for ZER1 Gene

Residual Variation Intolerance Score: 14.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZER1 Gene

HapMap Linkage Disequilibrium report
ZER1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZER1 Gene

Disorders for ZER1 Gene

Relevant External Links for ZER1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZER1

No disorders were found for ZER1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZER1 Gene

Publications for ZER1 Gene

  1. Meiotic human sperm cells express a leucine-rich homologue of Caenorhabditis elegans early embryogenesis gene, Zyg-11. (PMID: 11719588) Feral C. … Guellaen G. (Mol. Hum. Reprod. 2001) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Genetic variants associated with disordered eating. (PMID: 23568457) Wade T.D. … Martin N.G. (Int J Eat Disord 2013) 3
  4. Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. (PMID: 24144296) Cheng C.Y. … Baird P.N. (Am. J. Hum. Genet. 2013) 3
  5. Cytoskeletal scaffolding proteins interact with Lynch-Syndrome associated mismatch repair protein MLH1. (PMID: 20706999) Brieger A. … Trojan J. (Proteomics 2010) 3

Products for ZER1 Gene

Sources for ZER1 Gene

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