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Aliases for ZER1 Gene

Aliases for ZER1 Gene

  • Zyg-11 Related, Cell Cycle Regulator 2 3
  • Zyg-11 Homolog B-Like Protein 3 4
  • C9orf60 3 4
  • ZYG11BL 3 4
  • ZYG 3 4
  • Chromosome 9 Open Reading Frame 60 2
  • Zyg-11 Homolog B (C. Elegans)-Like 2
  • Zer-1 Homolog (C. Elegans) 2
  • Protein Zer-1 Homolog 3
  • Zer-1 Homolog 3
  • ZYG Homolog 3
  • Hzyg 4

External Ids for ZER1 Gene

Previous Symbols for ZER1 Gene

  • C9orf60
  • ZYG11BL

Summaries for ZER1 Gene

Entrez Gene Summary for ZER1 Gene

  • This gene encodes a subunit of an E3 ubiquitin ligase complex that may be involved in meiosis. The encoded protein contains three leucine-rich repeat motifs. [provided by RefSeq, Nov 2012]

GeneCards Summary for ZER1 Gene

ZER1 (Zyg-11 Related, Cell Cycle Regulator) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is ZYG11A.

UniProtKB/Swiss-Prot for ZER1 Gene

  • Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZER1-CUL2-Elongin BC.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZER1 Gene

Genomics for ZER1 Gene

Genomic Location for ZER1 Gene

Start:
128,729,786 bp from pter
End:
128,772,414 bp from pter
Size:
42,629 bases
Orientation:
Minus strand

Genomic View for ZER1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZER1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZER1 Gene

Regulatory Elements for ZER1 Gene

Proteins for ZER1 Gene

  • Protein details for ZER1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7L7-ZER1_HUMAN
    Recommended name:
    Protein zer-1 homolog
    Protein Accession:
    Q7Z7L7
    Secondary Accessions:
    • O00156
    • Q5T272
    • Q5T273

    Protein attributes for ZER1 Gene

    Size:
    766 amino acids
    Molecular mass:
    88169 Da
    Quaternary structure:
    • Interacts with the TCEB1-TCEB2/Elongin BC complex. Part of an E3 ubiquitin ligase complex including ZER1, CUL2 and Elongin BC.
    SequenceCaution:
    • Sequence=CAI15408.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15409.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ZER1 Gene

Proteomics data for ZER1 Gene at MOPED

Post-translational modifications for ZER1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys31, Lys119, and Lys323

Other Protein References for ZER1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZER1 Gene

Domains for ZER1 Gene

Gene Families for ZER1 Gene

HGNC:
  • ZYG11 :ZYG11 cell cycle regulator family

Protein Domains for ZER1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

ZER1_HUMAN
Family:
  • Belongs to the zyg-11 family.:
    • Q7Z7L7
Similarity:
  • Contains 5 ARM repeats.:
    • Q7Z7L7
  • Contains 3 LRR (leucine-rich) repeats.:
    • Q7Z7L7
genes like me logo Genes that share domains with ZER1: view

Function for ZER1 Gene

Molecular function for ZER1 Gene

UniProtKB/Swiss-Prot Function: Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZER1-CUL2-Elongin BC.

Gene Ontology (GO) - Molecular Function for ZER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IMP 17304241
GO:0005488 binding --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ZER1: view

Phenotypes for ZER1 Gene

genes like me logo Genes that share phenotypes with ZER1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZER1 Gene

Localization for ZER1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZER1 Gene COMPARTMENTS Subcellular localization image for ZER1 gene
Compartment Confidence
cytoskeleton 3
cytosol 2
vacuole 2

Gene Ontology (GO) - Cellular Components for ZER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031462 Cul2-RING ubiquitin ligase complex IDA 17304241
genes like me logo Genes that share ontologies with ZER1: view

Pathways for ZER1 Gene

SuperPathways for ZER1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IMP 17304241
GO:0051438 regulation of ubiquitin-protein transferase activity IMP 17304241
genes like me logo Genes that share ontologies with ZER1: view

No data available for Pathways by source for ZER1 Gene

Transcripts for ZER1 Gene

Unigene Clusters for ZER1 Gene

Zyg-11 related, cell cycle regulator:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZER1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18
SP1:
SP2:
SP3:
SP4: - - -
SP5: - -
SP6: -

Relevant External Links for ZER1 Gene

GeneLoc Exon Structure for
ZER1
ECgene alternative splicing isoforms for
ZER1

Expression for ZER1 Gene

mRNA expression in normal human tissues for ZER1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZER1 Gene

SOURCE GeneReport for Unigene cluster for ZER1 Gene Hs.147950

mRNA Expression by UniProt/SwissProt for ZER1 Gene

Q7Z7L7-ZER1_HUMAN
Tissue specificity: Expressed in testis, spermatocytes and spermatids (at protein level). Expressed in spermatocytes, spermatids, prostate, skeletal muscle, ovary, small intestine, heart, brain and pancreas.
genes like me logo Genes that share expressions with ZER1: view

Orthologs for ZER1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZER1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZER1 36
  • 99.61 (n)
  • 99.87 (a)
ZER1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZER1 36
  • 92.34 (n)
  • 98.3 (a)
ZER1 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZER1 36
  • 92.69 (n)
  • 98.04 (a)
ZER1 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zer1 36
  • 89.25 (n)
  • 96.34 (a)
Zer1 16
Zer1 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZER1 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZER1 37
  • 40 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zer1 36
  • 89.38 (n)
  • 96.34 (a)
chicken
(Gallus gallus)
Aves ZER1 36
  • 80.68 (n)
  • 89.95 (a)
ZER1 37
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC69020 36
tropical clawed frog
(Silurana tropicalis)
Amphibia zer1 36
  • 75.48 (n)
  • 83.27 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6570 36
zebrafish
(Danio rerio)
Actinopterygii zer1 36
  • 70.38 (n)
  • 70.68 (a)
zer1 37
  • 66 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005961 36
  • 51.16 (n)
  • 39.66 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12084 36
  • 52.07 (n)
  • 40.94 (a)
CG12084 37
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea zer-1 36
  • 48.11 (n)
  • 40.93 (a)
zer-1 37
  • 26 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 29 (a)
OneToOne
Species with no ortholog for ZER1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZER1 Gene

ENSEMBL:
Gene Tree for ZER1 (if available)
TreeFam:
Gene Tree for ZER1 (if available)

Paralogs for ZER1 Gene

Paralogs for ZER1 Gene

genes like me logo Genes that share paralogs with ZER1: view

Variants for ZER1 Gene

Sequence variations from dbSNP and Humsavar for ZER1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs8507 -- 128,753,268(+) AAGGC(G/T)GCGTC synonymous-codon, reference
rs11097 -- 128,753,504(-) TGAGC(A/C)TCTTC missense, reference
rs1046742 -- 128,740,016(-) TCTGT(A/G)AGCCC missense, reference
rs1139045 -- 128,736,001(-) actgc(A/G)ctcca intron-variant
rs1140025 -- 128,771,683(-) CCTCC(C/T)GAGGT utr-variant-5-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZER1 Gene

Variant ID Type Subtype PubMed ID
nsv893901 CNV Loss 21882294
nsv893902 CNV Gain 21882294
dgv8296n71 CNV Loss 21882294

Relevant External Links for ZER1 Gene

HapMap Linkage Disequilibrium report
ZER1

Disorders for ZER1 Gene

No disorders were found for ZER1 Gene.

No data available for UniProtKB/Swiss-Prot for ZER1 Gene

Publications for ZER1 Gene

  1. Meiotic human sperm cells express a leucine-rich homologue of Caenorhabditis elegans early embryogenesis gene, Zyg-11. (PMID: 11719588) Feral C. … Guellaen G. (Mol. Hum. Reprod. 2001) 2 3 4 23
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components. (PMID: 17304241) Vasudevan S. … Kipreos E.T. (EMBO Rep. 2007) 3 4
  5. Characterization of Cullin-box sequences that direct recruitment of Cul2-Rbx1 and Cul5-Rbx2 modules to Elongin BC-based ubiquitin ligases. (PMID: 18187417) Mahrour N. … Conaway J.W. (J. Biol. Chem. 2008) 3

Products for ZER1 Gene

  • Addgene plasmids for ZER1

Sources for ZER1 Gene

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