Aliases for ZEB2 Gene
External Ids for ZEB2 Gene
Previous HGNC Symbols for ZEB2 Gene
Previous GeneCards Identifiers for ZEB2 Gene
The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010]
GeneCards Summary for ZEB2 Gene
ZEB2 (Zinc Finger E-Box Binding Homeobox 2) is a Protein Coding gene. Diseases associated with ZEB2 include Mowat-Wilson Syndrome and Mowat-Wilson Syndrome Due To A Zeb2 Point Mutation. Among its related pathways are TGF-beta Receptor Signaling Pathway and TGF Beta Signaling Pathway. GO annotations related to this gene include nucleic acid binding and phosphatase regulator activity. An important paralog of this gene is ZEB1.
UniProtKB/Swiss-Prot for ZEB2 Gene
Transcriptional inhibitor that binds to DNA sequence 5-CACCT-3 in different promoters. Represses transcription of E-cadherin.