ZEB2 Gene

Aliases
for ZEB2 gene

Previous GC identifers: GC02M144863 GC02M145145 GC02M137133

Summaries
for ZEB2 gene

Genomic Views
for ZEB2 gene

RefSeq DNA sequence:

NC_000002.11  NC_018913.1  NT_022135.16  

SwitchGear Promoter luciferase reporter plasmid: ZEB2 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZEB2

ZEB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M145121:  view genomic region     (about GC identifiers)

Proteins
for ZEB2 gene

1 PDB 3D structure from and Proteopedia for ZEB2:

2DA7 (3D)    

Explore the universe of human proteins at neXtProt for ZEB2: NX_O60315

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for ZEB2
	GenScript Custom Purified and Recombinant Proteins Services for ZEB2
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ZEB2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ZEB2
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for ZEB2
	GenScript Custom Superior Antibodies Services for ZEB2
	Novus Biologicals ZEB2 Antibodies
	Search for Antibodies for ZEB2 at Abcam
	Uscn Antibodies for ZEB2
	ThermoFisher Antibodies for ZEB2

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ZEB2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ZEB2

Protein Domains /
Families
for ZEB2 gene

ProtoNet protein and cluster: O60315

Function
for ZEB2 gene

miRNA Products:		miRTarBase miRNAs that target ZEB2: hsa-mir-200a (MIRT001035), hsa-mir-429 (MIRT000048), hsa-mir-200c (MIRT001036), hsa-mir-141 (MIRT000316), hsa-mir-205 (MIRT003666), hsa-mir-200b (MIRT000723)
		OriGene 3'-UTR Clone: ZEB2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZEB2
		8/173 QIAGEN miScript miRNA Assays for microRNAs that regulate ZEB2 (see all 173):
		hsa-miR-411* hsa-miR-26a-2* hsa-miR-199a-3p hsa-miR-605 hsa-miR-1245 hsa-miR-342-3p hsa-miR-409-5p hsa-miR-298
		SwitchGear 3'UTR luciferase reporter plasmid: ZEB2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZEB2 (see all 7) OriGene shRNA RFP: ZEB2 OriGene siRNA: ZEB2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZEB2

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for ZEB2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZEB2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZEB2 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ZEB2 (NM_014795)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZEB2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZEB2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ZEB2
		Search LifeMap BioReagents cell lines for ZEB2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZEB2

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

(inferred from 3 alleles) (MGI details for Zeb2)

Pathways & Interactions
for ZEB2 gene

	Super-pathway	contained gene-specific pathways
1	TGF Beta Signaling Pathway	TGF Beta Signaling Pathway 1.00
2	TGF-beta Receptor Signaling Pathway	TGF-beta Receptor Signaling Pathway 1.00

2 BioSystems Pathways for ZEB2

	TGF Beta Signaling Pathway
	TGF-beta Receptor Signaling Pathway

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

Drugs & Compounds
for ZEB2 gene

Transcripts
for ZEB2 gene

Expression
for ZEB2 gene

ZEB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCGAATAAA

3 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BrainCerebral Cortex			Brain
	KidneyMetanephros			Kidney
	Reproductive SystemMesonephros			Reproductive System
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZEB2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZEB2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZEB2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZEB2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZEB2

Orthologs
for ZEB2 gene

Paralogs
for ZEB2 gene

Paralogs for ZEB2 gene

ZEB1²  

18/36 SIMAP similar genes for ZEB2 using alignment to 8 protein entries:     ZEB2_HUMAN (see all proteins) (see all similar genes):

ZFHX1B    HZF40    kr-znf3    ZFS-5    ZEB1    DKFZp686M04222

ZNF468    ZNF22    smap-7    A-328A3.4    ZNF323    zf30

ZNF72    ZNF78L1    ZNF55    ZNF    ZFS-2    ZNF663

ZEB2 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for ZEB2
PGOHUM00000245474

Genomic Variants
for ZEB2 gene

10/1853 NCBI SNPs in ZEB2 are shown (see all 1853)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs797260931,2	F,	--	137132860(+)	CAAGAC/TCAAAT	2	--	ds5001		1		WA	118
rs767293341,2	F,	--	137134752(+)	ATTGCA/CCAGAT	2	--	ut31		1		WA	118
rs729921381,2	C,	--	137134953(+)	GTGGAG/CGGGAA	2	--	ut31		1		WA	2
rs621692011,2	C,	--	137135055(+)	CAATCG/ATGTCC	2	--	ut31		2		NA	122
rs739649891,2	C,	--	137135570(+)	GGCTGC/TGGATA	2	--	ut31		1		WA	2
rs1120751231,2		--	137136797(+)	GTCATC/TATGTA	2	--	ut31		1		CSA	2
rs745839081,2	F,	--	137137035(+)	TAATAG/CCTGTC	2	--	ut31		1		WA	118
rs621692021,2		--	137137482(+)	ATTCAG/ATAATA	2	--	ut31		1		NA	2
rs560157191,2	C	--	137137615(+)	TTTCAC/TAAGAT	2	--	ut31		0	--	--	--	--
rs557117241,2	C	--	137138295(+)	AGAAAA/GAAAAA	2	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZEB2 (145141942 - 145282147 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZEB2
     1 CNV: 6003
Human Gene Mutation Database (HGMD): ZEB2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZEB2

DNA2.0 Custom Variant and Variant Library Synthesis for ZEB2

Disorders / Diseases
for ZEB2 gene

20/35 diseases for ZEB2

10/20 Novoseek disease relationships for ZEB2 gene (see all 20)    About this table

Publications
for ZEB2 gene

PubMed articles for ZEB2 gene, integrated from 9 sources (see all 143): (articles sorted by number of sources associating them with ZEB2)

Utopia: connect your pdf to the dynamic world of online information

1. Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin. (PubMed id 16061479)^{1, 2, 9} Long J.... Park M. (2005)
2. Ocular coloboma and high myopia with Hirschsprung disease associated with a novel ZFHX1B missense mutation and trisomy 21. (PubMed id 15384097)^{1, 2, 9} Gregory-Evans C.Y....Gregory-Evans K. (2004)
3. Mutations in SIP1, encoding Smad interacting protein 1, cause a form of Hirschsprung disease. (PubMed id 11279515)^{1, 2, 9} Wakamatsu N....Nagaya M. (2001)
4. A missense mutation in the ZFHX1B gene associated with an atypical Mowat-Wilson syndrome phenotype. (PubMed id 16688751)^{1, 2, 9} Heinritz W.... Schuster V. (2006)
5. Loss-of-function mutations in SIP1 Smad interacting protein 1 result in a syndromic Hirschsprung disease. (PubMed id 11448942)^{1, 2, 9} Cacheux V.... Goossens M. (2001)
6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
7. Late infantile Hirschsprung disease-mental retardation syndrome with a 3-bp deletion in ZFHX1B. (PubMed id 12451214)^{1, 2} Yoneda M.... Wakamatsu N. (2002)
8. Selection system for genes encoding nuclear-targeted proteins. (PubMed id 9853615)^{1, 2} Ueki N.... Muramatsu M.-A. (1998)
9. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)^{1, 2} Nagase T....Ohara O. (1998)
10. Expression of SIP1 in oral squamous cell carcinomas: implications for E-cadherin expression and tumor progression. (PubMed id 16273209)^{1, 9} Maeda G....Imai K. (2005)

External Searches for ZEB2 gene

Genome Databases showing ZEB2 gene

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Products
for ZEB2 gene