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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZEB1 Gene

protein-coding   GIFtS: 63
GCID: GC10P031648

Zinc Finger E-Box Binding Homeobox 1

(Previous names: transcription factor 8 (represses interleukin 2 expression),...)
(Previous symbols: TCF8, PPCD3)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger E-Box Binding Homeobox 11 2     DELTAEF12
TCF81 2 3 5     ZFHEP2
PPCD31 2 5     ZFHX1A2
Posterior Polymorphous Corneal Dystrophy 31 2     Delta-Crystallin Enhancer Binding Factor 12
Transcription Factor 8 (Represses Interleukin 2 Expression)1 2     Zinc Finger E-Box-Binding Homeobox 12
Negative Regulator Of IL22 3     Zinc Finger Homeodomain Enhancer-Binding Protein2
AREB62 3     TCF-83
FECD62 5     NIL-2-A Zinc Finger Protein3
NIL2A2 5     Transcription Factor 83
BZP2     

External Ids:    HGNC: 116421   Entrez Gene: 69352   Ensembl: ENSG000001485167   OMIM: 1899095   UniProtKB: P372753   

Export aliases for ZEB1 gene to outside databases

Previous GC identifer: GC10P031330


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZEB1 Gene:
This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional
repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal
dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants
encoding different isoforms have been described.(provided by RefSeq, Mar 2010)

GeneCards Summary for ZEB1 Gene: 
ZEB1 (zinc finger E-box binding homeobox 1) is a protein-coding gene. Diseases associated with ZEB1 include corneal dystrophy, posterior polymorphous, 3, and corneal dystrophy, fuchs endothelial, 6. GO annotations related to this gene include transcription coactivator activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZEB2.

UniProtKB/Swiss-Prot: ZEB1_HUMAN, P37275
Function: Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or
represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type.
Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1.
Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal
differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding
to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs

Gene Wiki entry for ZEB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_008705.16  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZEB1 gene promoter:
         AREB6   MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZEB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZEB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZEB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p11.2   Ensembl cytogenetic band:  10p11.22   HGNC cytogenetic band: 10p11.22

ZEB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZEB1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P031648:  view genomic region     (about GC identifiers)

Start:
31,607,424 bp from pter      End:
31,818,742 bp from pter
Size:
211,319 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZEB1_HUMAN, P37275 (See protein sequence)
Recommended Name: Zinc finger E-box-binding homeobox 1  
Size: 1124 amino acids; 124074 Da
Subunit: Interacts (via N-terminus) with SMARCA4/BRG1
Subcellular location: Nucleus
Sequence caution: Sequence=BAG62481.1; Type=Frameshift; Positions=177;
1 PDB 3D structure from and Proteopedia for ZEB1:
2E19 (3D)    
Secondary accessions: B4DJV0 B4DUW9 E9PCM7 F5H4I8 Q12924 Q13800 Q2KJ05 Q5T968 Q5VZ84 Q8NB68
Alternative splicing: 5 isoforms:  P37275-1   P37275-2   P37275-3   P37275-4   P37275-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZEB1: NX_P37275

Explore proteomics data for ZEB1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P37275

  • ZEB1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZEB1 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001121600.1  NP_001167564.1  NP_001167565.1  NP_001167566.1  NP_001167567.1  NP_110378.3  

    ENSEMBL proteins: 
     ENSP00000319248   ENSP00000452787   ENSP00000453970   ENSP00000415961   ENSP00000405958  
     ENSP00000444891   ENSP00000453559   ENSP00000453823   ENSP00000453674   ENSP00000354487  
     ENSP00000391612  

    Human Recombinant Protein Products for ZEB1: 
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    Novus Biologicals ZEB1 Proteins
    Novus Biologicals ZEB1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005667transcription factor complex IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    ZEB1 for ontologies           About GeneDecksing



    ZEB1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ZEB1
    R&D Systems Antibodies for ZEB1
    Cell Signaling Technology (CST) Antibodies for ZEB1  (TCF8)
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    Novus Biologicals ZEB1 Antibodies
    Abcam antibodies for ZEB1
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    ThermoFisher Antibodies for ZEB1
    LSBio Antibodies in human, mouse, rat for ZEB1 

    Assay Products for ZEB1: 
    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZFHX: Homeoboxes / ZF class
    ZNF: Zinc fingers, C2H2-type

    5 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P37275

    ProtoNet protein and cluster: P37275

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZEB1_HUMAN, P37275
    Similarity: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family
    Similarity: Contains 7 C2H2-type zinc fingers
    Similarity: Contains 1 homeobox DNA-binding domain


    ZEB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZEB1_HUMAN, P37275
    Function: Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or
    represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type.
    Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1.
    Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal
    differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding
    to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs

         Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003690double-stranded DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
         
    ZEB1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZEB1:
     Increased S DNA content 

         15/25 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Zeb1) (see all 25):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size  hearing/vestibular/ear 
     hematopoietic system  homeostasis/metabolism  immune system  integument  limbs/digits/tail 

    ZEB1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Zeb1tm1Yhi for ZEB1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZEB1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZEB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZEB1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZEB1 

    10/2429 SABiosciences Target genes for ZEB1 (see all 2429):
    A2M AANAT AATK ABCA6 ABCA8 ABCB8 ABCC10 ABCC12 ABCC5 ABCC6P1

    miRNA
    Products:
        
    miRTarBase miRNAs that target ZEB1:
    hsa-mir-200c (MIRT002286), hsa-mir-200b (MIRT002483), hsa-mir-200a (MIRT002480), hsa-mir-205 (MIRT002478), hsa-mir-141 (MIRT000317), hsa-mir-429 (MIRT001743)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZEB1
    8/105 QIAGEN miScript miRNA Assays for microRNAs that regulate ZEB1 (see all 105):
    hsa-miR-3146 hsa-miR-199a-3p hsa-miR-485-3p hsa-miR-200a hsa-miR-3653 hsa-miR-342-3p hsa-miR-629* hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidZEB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 6): ZEB1 (NM_001128128)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZEB1
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                         Customized lentivirus expression plasmids for stable overexpression of ZEB1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZEB1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZEB1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer
    2TGF-beta Receptor Signaling Pathway
    TGF-beta Receptor Signaling Pathway
    3MicroRNAs in cancer
    MicroRNAs in cancer
    4Diuretics Pathway, Pharmacodynamics
    Diuretics Pathway, Pharmacodynamics
    5Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for ZEB1
        Wnt / Hedgehog / Notch

    1 BioSystems Pathway for ZEB1
        TGF-beta Receptor Signaling Pathway

    1 PharmGKB Pathway for ZEB1
        Diuretics Pathway, Pharmacodynamics

    2         Kegg Pathways  (Kegg details for ZEB1):
        Transcriptional misregulation in cancer
    MicroRNAs in cancer


    ZEB1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZEB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/18 Interacting proteins for ZEB1 (P372752, 3 ENSP000003192484) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTBP1Q133632, 3, ENSP000002909214MINT-17555 I2D: score=6 STRING: ENSP00000290921
    SMAD2Q157963, ENSP000002621604I2D: score=2 STRING: ENSP00000262160
    SMAD3P840223, ENSP000003329734I2D: score=2 STRING: ENSP00000332973
    SMAD7O151053, ENSP000002621584I2D: score=1 STRING: ENSP00000262158
    SMARCA4P515323, ENSP000003507204I2D: score=1 STRING: ENSP00000350720
    About this table

    Gene Ontology (GO): 5/29 biological process terms (GO ID links to tree view) (see all 29):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS8138542
    GO:0006955immune response TAS1840704

    ZEB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ZEB1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZEB1

    1 HMDB Compound for ZEB1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ZincZinc (see all 2)7440-66-6--

    2 Novoseek inferred chemical compound relationships for ZEB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 64.8 18 1427828 (2), 19011757 (1), 2248949 (1), 12477825 (1) (see all 10)
    vitamin d 18.7 7 16203744 (3), 16804902 (2), 19802011 (1)

    Search CenterWatch for drugs/clinical trials and news about ZEB1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZEB1 gene (6 alternative transcripts): 
    NM_001128128.2  NM_001174093.1  NM_001174094.1  NM_001174095.1  NM_001174096.1  NM_030751.5  

    Unigene Cluster for ZEB1:

    Zinc finger E-box binding homeobox 1
    Hs.124503  [show with all ESTs]
    Unigene Representative Sequence: NM_001128128
    18/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000488625 ENST00000560196 ENST00000542879 ENST00000561304 ENST00000320985(uc009xlj.1 uc010qeg.1 uc009xlk.1)
    ENST00000483752 ENST00000559858 ENST00000560721 ENST00000558440 ENST00000424869
    ENST00000437844(uc001ivr.4 uc010qef.2 uc009xlh.1 uc009xli.1 uc001ivt.4)
    ENST00000542815 ENST00000558863 ENST00000561212 ENST00000558655 ENST00000561061(uc009xll.2)
    ENST00000559496(uc009xlm.1 uc009xln.1) ENST00000559476

    miRNA
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    8/105 QIAGEN miScript miRNA Assays for microRNAs that regulate ZEB1 (see all 105):
    hsa-miR-3146 hsa-miR-199a-3p hsa-miR-485-3p hsa-miR-200a hsa-miR-3653 hsa-miR-342-3p hsa-miR-629* hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidZEB1 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZEB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZEB1
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    Additional mRNA sequence: 

    AK091478.1 AK294775.1 AK296244.1 AK299541.1 AK299666.1 AK300830.1 AK307510.1 AK308785.1 
    AK308822.1 AK309331.1 AK309399.1 AK310924.1 AK311116.1 AK311137.1 AK311187.1 AK311201.1 
    AK311372.1 AK311557.1 AK314683.1 AL831979.1 BC009572.1 BC065705.1 BC107781.1 BC112392.1 
    BX647794.1 M81699.1 U12170.1 

    16 DOTS entries:

    DT.99982248  DT.92436781  DT.100794496  DT.95070818  DT.95070805  DT.100794497  DT.121247574  DT.95264874 
    DT.100794498  DT.100805122  DT.121247548  DT.121247629  DT.92436780  DT.95136334  DT.40296564  DT.92436784 

    24/224 AceView cDNA sequences (see all 224):

    AU134735 BP364438 AL710239 BU631407 AA258522 AA400754 CA412312 BM994180 
    AI264292 AI051560 AA447846 D57587 BQ003893 BQ888755 AI367546 BU517351 
    AI591345 AA255488 BQ009469 CD675003 BE673922 AA256384 CB145245 C05511 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZEB1 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:        -           -     -                                                                           
    SP2:                          -           -                                                               
    SP3:                          -     -     -     -     -                                                   
    SP4:                          -     -     -     -     -           -                                       
    SP5:                    -     -           -                                                               


    ECgene alternative splicing isoforms for ZEB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZEB1 expression in normal human tissues (normalized intensities)      ZEB1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCATTTTCT
    ZEB1 Expression
    About this image


    ZEB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
             brain/midbrain   
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             pre Conventional Dendritic Cells Peripheral Blood
             cd31+ cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   
             Appendix   
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             colon ; endothelial cells   
             cd31+ cells   
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             S-shaped Body
             kidney ; cells in glomeruli   

    See ZEB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZEB1

    SOURCE GeneReport for Unigene cluster: Hs.124503

    UniProtKB/Swiss-Prot: ZEB1_HUMAN, P37275
    Tissue specificity: Colocalizes with SMARCA4/BRG1 in E-cadherin-negative cells from established lines, and stroma
    of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas
    (at protein level). Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas

        SABiosciences Expression via Pathway-Focused PCR Arrays including ZEB1: 
              T Helper Cell Differentiation in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZEB1 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zeb11 , 5 zinc finger E-box binding homeobox 11, 5 85.88(n)1
    88.55(a)1
      18 (4.42 cM)5
    214171  NM_011546.31  NP_035676.11 
     55918605 
    chicken
    (Gallus gallus)
    Aves ZEB11 zinc finger E-box binding homeobox 1 83.6(n)
    86.33(a)
      396029  NM_205131.1  NP_990462.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZEB16
    Uncharacterized protein
    82(a)
    1 ↔ 1
    6(12786118-12808207)
    zebrafish
    (Danio rerio)
    Actinopterygii zfhx12 zinc finger homeobox 1 76.62(n)   114425  AB016799.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta zfh16
    Zn finger homeodomain 1
    19(a)
    1 → many
    3R(26591648-26614205)
    worm
    (Caenorhabditis elegans)
    Secernentea zag-16
    Zinc finger E-box-binding homebox protein zag-1
    27(a)
    1 → many
    IV(3855843-3861124)


    ENSEMBL Gene Tree for ZEB1 (if available)
    TreeFam Gene Tree for ZEB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZEB1 gene
    ZEB22  ZNF222  
    18/49 SIMAP similar genes for ZEB1 using alignment to 18 protein entries:     ZEB1_HUMAN (see all proteins) (see all similar genes):
    ZNF135    ZNF419    HZF40    ZNF559    ZNF786    ZNF26
    ZNF417    ZNF460    ZFHX1B    ZNF78L1    ZEB2    ZFS-5
    smap-7    ZNF22    ZNF692    ZNF782    ZNF426    ZNF480

    ZEB1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3025 SNPs in ZEB1 are shown (see all 3025)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0637634
    Corneal dystrophy, Fuchs endothelial, 6 (FECD6)4--see VAR_0637632 A T mis40--------
    VAR_0637614
    Corneal dystrophy, Fuchs endothelial, 6 (FECD6)4--see VAR_0637612 Q P mis40--------
    VAR_0637604
    Corneal dystrophy, Fuchs endothelial, 6 (FECD6)4--see VAR_0637602 P A mis40--------
    rs801945311,2,4
    C,FCorneal dystrophy, Fuchs endothelial, 6 (FECD6)4 pathogenic131750140(+) AGGGAA/CTGCTA 11 N T mis1 int13Minor allele frequency- C:0.02WA NA EU 5977
    rs1180209011,2,4
    C,FCorneal dystrophy, Fuchs endothelial, 6 (FECD6)4 pathogenic131810782(+) TCCCCA/CGGTGG 12 Q P mis13Minor allele frequency- C:0.00NA EU 5993
    rs1456716081,2
    --31328582(+) CTCCCC/TGCCCC 2 -- us2k10--------
    rs78965971,2
    A--31648263(+) TAAAAG/TGAGAA 6 -- int10--------
    rs78966891,2
    A--31648275(+) TCTTAG/TGTGTT 6 -- int10--------
    rs79112751,2
    A,H--31648310(+) AAGAGA/GGGGAA 6 -- int1 trp34Minor allele frequency- G:0.00NS EA 416
    rs1472006221,2
    C--31648445(+) GTTAAC/TACAGG 6 -- int10--------

    HapMap Linkage Disequilibrium report for ZEB1 (31607424 - 31818742 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZEB1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831826CNV Loss17160897
    nsv831824CNV Loss17160897


    Human Gene Mutation Database (HGMD): ZEB1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 189909   
    OMIM disorders: 609141  613270  
    UniProtKB/Swiss-Prot: ZEB1_HUMAN, P37275
  • Corneal dystrophy, posterior polymorphous, 3 (PPCD3) [MIM:609141]: A subtype of posterior corneal
    dystrophy, a disease characterized by alterations of Descemet membrane presenting as vesicles, opacities or
    band-like lesions on slit-lamp examination and specular microscopy. Affected patient typically are asymptomatic.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Corneal dystrophy, Fuchs endothelial, 6 (FECD6) [MIM:613270]: A corneal disease caused by loss of
    endothelium of the central cornea. It is characterized by focal wart-like guttata that arise from Descemet
    membrane and develop in the central cornea, epithelial blisters, reduced vision and pain. Descemet membrane is
    thickened by abnormal collagenous deposition. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 20/43 diseases for ZEB1 (see all 43):    About MalaCards
    corneal dystrophy, posterior polymorphous, 3    corneal dystrophy, fuchs endothelial, 6    posterior polymorphous corneal dystrophy    corneal dystrophy
    severe hypospadias    endotheliitis    congenital hypothyroidism    gallbladder cancer
    hypospadias    hypothyroidism    adult t-cell leukemia    hernia
    malignant pleural mesothelioma    fanconi's anemia    leiomyoma    t-cell leukemia
    glaucoma    colon cancer    lung adenocarcinoma    anemia


    ZEB1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    6 Novoseek inferred disease relationships for ZEB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    posterior polymorphous corneal dystrophy 92 6 17935237 (2), 20036349 (1), 18172091 (1), 17437275 (1) (see all 5)
    epithelial tumor 30.7 1 16585218 (1)
    cancer 26.1 8 19011757 (1), 20160487 (1), 11432806 (1), 18622689 (1) (see all 7)
    colon carcinoma 21.1 4 16804902 (2), 11432806 (1)
    tumors 20.6 14 12161443 (2), 19802011 (2), 16585218 (2), 16804902 (2) (see all 6)
    colon cancer 15.9 4 16203744 (3), 16804902 (1)

    Genetic Association Database (GAD): ZEB1
    Human Genome Epidemiology (HuGE) Navigator: ZEB1 (4 documents)

    Export disorders for ZEB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZEB1 gene, integrated from 9 sources (see all 183):
    (articles sorted by number of sources associating them with ZEB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in TCF8 cause posterior polymorphous corneal dystrophy and ectopic expression of COL4A3 by corneal endothelial cells. (PubMed id 16252232)1, 2, 3, 9 Krafchak C.M....Richards J.E. (2005)
    2. Identification of a zinc finger protein that inhibits IL-2 gene expression. (PubMed id 1840704)1, 2, 3 Williams T.M.... Kant J.A. (1991)
    3. Posterior polymorphous corneal dystrophy is associated with TCF8 gene mutations and abdominal hernia. (PubMed id 17935237)1, 4, 9 Aldave A.J....Richards J.E. (2007)
    4. Analysis of the posterior polymorphous corneal dystrophy 3 gene, TCF8, in late-onset Fuchs endothelial corneal dystrophy. (PubMed id 18172091)1, 4, 9 Mehta J.S....Aung T. (2008)
    5. The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2. (PubMed id 1427828)1, 3, 9 Williams T.M....Shows T.B. (1992)
    6. Missense mutations in TCF8 cause late-onset Fuchs cor neal dystrophy and interact with FCD4 on chromosome 9p. (PubMed id 20036349)1, 2, 9 Riazuddin S.A....Katsanis N. (2010)
    7. ZEB1 and CtBP form a repressive complex at a distal p romoter element of the BCL6 locus. (PubMed id 20175752)1, 2 Papadopoulou V....Wagner S.D. (2010)
    8. ZEB1 represses E-cadherin and induces an EMT by recru iting the SWI/SNF chromatin-remodeling protein BRG1. (PubMed id 20418909)1, 2 SA!nchez-TillA^ E....Postigo A. (2010)
    9. The EMT-activator ZEB1 promotes tumorigenicity by rep ressing stemness-inhibiting microRNAs. (PubMed id 19935649)1, 2 Wellner U....Brabletz T. (2009)
    10. KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise. (PubMed id 18984674)1, 4 Argyropoulos G....Rankinen T. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6935 HGNC: 11642 AceView: TCF8 Ensembl:ENSG00000148516 euGenes: HUgn6935
    ECgene: ZEB1 Kegg: 6935 H-InvDB: ZEB1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZEB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZEB1 gene:
    Search GeneIP for patents involving ZEB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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