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ZEB1 Gene

protein-coding   GIFtS: 63
GCID: GC10P031648

Zinc Finger E-Box Binding Homeobox 1

(Previous names: transcription factor 8 (represses interleukin 2 expression),...)
(Previous symbols: TCF8, PPCD3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger E-Box Binding Homeobox 11 2     DELTAEF12
TCF81 2 3 5     ZFHEP2
PPCD31 2 5     ZFHX1A2
Posterior Polymorphous Corneal Dystrophy 31 2     Delta-Crystallin Enhancer Binding Factor 12
Transcription Factor 8 (Represses Interleukin 2 Expression)1 2     Zinc Finger E-Box-Binding Homeobox 12
Negative Regulator Of IL22 3     Zinc Finger Homeodomain Enhancer-Binding Protein2
AREB62 3     TCF-83
FECD62 5     NIL-2-A Zinc Finger Protein3
NIL2A2 5     Transcription Factor 83
BZP2     

External Ids:    HGNC: 116421   Entrez Gene: 69352   Ensembl: ENSG000001485167   OMIM: 1899095   UniProtKB: P372753   

Export aliases for ZEB1 gene to outside databases

Previous GC identifer: GC10P031330


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZEB1 Gene:
This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional
repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal
dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants
encoding different isoforms have been described.(provided by RefSeq, Mar 2010)

GeneCards Summary for ZEB1 Gene:
ZEB1 (zinc finger E-box binding homeobox 1) is a protein-coding gene. Diseases associated with ZEB1 include corneal dystrophy, posterior polymorphous, 3, and corneal dystrophy, fuchs endothelial, 6. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF324.

UniProtKB/Swiss-Prot: ZEB1_HUMAN, P37275
Function: Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or
represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type.
Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1.
Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal
differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding
to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs

Gene Wiki entry for ZEB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_008705.17  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZEB1 gene promoter:
         AREB6   MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZEB1 promoter sequence
   Search Chromatin IP Primers for ZEB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZEB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p11.2   Ensembl cytogenetic band:  10p11.22   HGNC cytogenetic band: 10p11.22

ZEB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZEB1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P031648:  view genomic region     (about GC identifiers)

Start:
31,607,424 bp from pter      End:
31,818,742 bp from pter
Size:
211,319 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZEB1_HUMAN, P37275 (See protein sequence)
Recommended Name: Zinc finger E-box-binding homeobox 1  
Size: 1124 amino acids; 124074 Da
Subunit: Interacts (via N-terminus) with SMARCA4/BRG1
Sequence caution: Sequence=BAG62481.1; Type=Frameshift; Positions=177;
1 PDB 3D structure from and Proteopedia for ZEB1:
2E19 (3D)    
Secondary accessions: B4DJV0 B4DUW9 E9PCM7 F5H4I8 Q12924 Q13800 Q2KJ05 Q5T968 Q5VZ84 Q8NB68
Alternative splicing: 5 isoforms:  P37275-1   P37275-2   P37275-3   P37275-4   P37275-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZEB1: NX_P37275

Explore proteomics data for ZEB1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys195
  • Modification sites at PhosphoSitePlus

  • See ZEB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001121600.1  NP_001167564.1  NP_001167565.1  NP_001167566.1  NP_001167567.1  NP_110378.3  

    ENSEMBL proteins: 
     ENSP00000319248   ENSP00000452787   ENSP00000453970   ENSP00000415961   ENSP00000405958  
     ENSP00000444891   ENSP00000453559   ENSP00000453823   ENSP00000453674   ENSP00000354487  
     ENSP00000391612  

    ZEB1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ZEB1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ZEB1
    GenScript Custom Purified and Recombinant Proteins Services for ZEB1
    Novus Biologicals ZEB1 Proteins
    Novus Biologicals ZEB1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    ZEB1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ZEB1
    R&D Systems Antibodies for ZEB1
    Cell Signaling Technology (CST) Antibodies for ZEB1  (TCF8)
    OriGene Antibodies for ZEB1
    OriGene Custom Antibody Services for ZEB1
    Novus Biologicals ZEB1 Antibodies
    Abcam antibodies for ZEB1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for ZEB1
    LSBio Antibodies in human, mouse, rat for ZEB1

    ZEB1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ZEB1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ZEB1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZFHX: Homeoboxes / ZF class
    ZNF: Zinc fingers, C2H2-type

    Selected InterPro protein domains (see all 6):
     IPR008598 Di19_Zn_binding
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P37275

    ProtoNet protein and cluster: P37275

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZEB1_HUMAN, P37275
    Similarity: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family
    Similarity: Contains 7 C2H2-type zinc fingers
    Similarity: Contains 1 homeobox DNA-binding domain


    ZEB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZEB1_HUMAN, P37275
    Function: Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or
    represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type.
    Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1.
    Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal
    differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding
    to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003690double-stranded DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
         
    ZEB1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZEB1:
     Increased S DNA content 

         Selected MGI mutant phenotypes (inferred from 6 alleles(MGI details for Zeb1) (see all 24):
     adipose tissue  behavior/neurological  cardiovascular system  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  mortality/aging 

    ZEB1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Zeb1tm1Yhi for ZEB1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZEB1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZEB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZEB1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZEB1

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for ZEB1 (see all 2382):
    A2M,  AANAT,  AATK,  ABCA6,  ABCA8,  ABCB8,  ABCC10,  ABCC12,  ABCC5,  ABCC6P1

    miRNA
    Products:
        
    miRTarBase miRNAs that target ZEB1:
    hsa-mir-200c-3p (MIRT002286), hsa-mir-200b-3p (MIRT002483), hsa-mir-205-5p (MIRT002478), hsa-mir-335-5p (MIRT018433), hsa-mir-141-3p (MIRT000317), hsa-mir-200a-3p (MIRT002480), hsa-mir-150-5p (MIRT006984), hsa-mir-130b-3p (MIRT007059), hsa-mir-429 (MIRT001743)

    Block miRNA regulation of human, mouse, rat ZEB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZEB1 (see all 105):
    hsa-miR-3146 hsa-miR-199a-3p hsa-miR-485-3p hsa-miR-200a hsa-miR-3653 hsa-miR-342-3p hsa-miR-629* hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidZEB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ZEB1
    Predesigned siRNA for gene silencing in human, mouse, rat ZEB1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ZEB1

    Clone
    Products:
         
    OriGene clones in human, mouse for ZEB1 (see all 29)
    OriGene ORF clones in mouse, rat for ZEB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): ZEB1 (NM_001128128)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZEB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZEB1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ZEB1
    Browse ESI BIO Cell Lines and PureStem Progenitors for ZEB1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZEB1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZEB1_HUMAN, P37275: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    cytoskeleton2
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005667transcription factor complex IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    ZEB1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZEB1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    2Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer
    3TGF-beta Receptor Signaling Pathway
    TGF-beta Receptor Signaling Pathway
    4MicroRNAs in cancer
    MicroRNAs in cancer
    5Hypertrophy Model
    Hypertrophy Model

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ZEB1 (see all 7)
        MAPK Signaling
    ILK Signaling
    Factors Promoting Cardiogenesis in Vertebrates
    Human Embryonic Stem Cell Pluripotency
    JNK Pathway

    1 Cell Signaling Technology (CST) Pathway for ZEB1
        Wnt / Hedgehog / Notch

    2 BioSystems Pathways for ZEB1
        TGF-beta Receptor Signaling Pathway
    Hypertrophy Model

    1 PharmGKB Pathway for ZEB1
        Diuretics Pathway, Pharmacodynamics

    2 Kegg Pathways  (Kegg details for ZEB1):
        Transcriptional misregulation in cancer
    MicroRNAs in cancer


    ZEB1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ZEB1: 
              T Helper Cell Differentiation in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ZEB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ZEB1 (P372752, 3 ENSP000003192484) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTBP1Q133632, 3, ENSP000002909214MINT-17555 I2D: score=6 STRING: ENSP00000290921
    SMAD2Q157963, ENSP000002621604I2D: score=2 STRING: ENSP00000262160
    SMAD3P840223, ENSP000003329734I2D: score=2 STRING: ENSP00000332973
    SMAD7O151053, ENSP000002621584I2D: score=1 STRING: ENSP00000262158
    SMARCA4P515323, ENSP000003507204I2D: score=1 STRING: ENSP00000350720
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 29):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS8138542
    GO:0006955immune response TAS1840704

    ZEB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZEB1

    1 HMDB Compound for ZEB1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ZincZinc (see all 2)7440-66-6--

    2 Novoseek inferred chemical compound relationships for ZEB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 64.8 18 1427828 (2), 19011757 (1), 2248949 (1), 12477825 (1) (see all 10)
    vitamin d 18.7 7 16203744 (3), 16804902 (2), 19802011 (1)



    ZEB1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZEB1 gene (6 alternative transcripts): 
    NM_001128128.2  NM_001174093.1  NM_001174094.1  NM_001174095.1  NM_001174096.1  NM_030751.5  

    Unigene Cluster for ZEB1:

    Zinc finger E-box binding homeobox 1
    Hs.124503  [show with all ESTs]
    Unigene Representative Sequence: NM_001128128
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000488625 ENST00000560196 ENST00000542879 ENST00000561304 ENST00000320985(uc009xlj.1 uc010qeg.1 uc009xlk.1)
    ENST00000483752 ENST00000559858 ENST00000560721 ENST00000558440 ENST00000424869
    ENST00000437844(uc001ivr.4 uc010qef.2 uc009xlh.1 uc009xli.1 uc001ivt.4)
    ENST00000542815 ENST00000558863 ENST00000561212 ENST00000558655 ENST00000561061(uc009xll.2)
    ENST00000559496(uc009xlm.1 uc009xln.1) ENST00000559476
    miRNA
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    Block miRNA regulation of human, mouse, rat ZEB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZEB1 (see all 105):
    hsa-miR-3146 hsa-miR-199a-3p hsa-miR-485-3p hsa-miR-200a hsa-miR-3653 hsa-miR-342-3p hsa-miR-629* hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidZEB1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZEB1
    Predesigned siRNA for gene silencing in human, mouse, rat ZEB1
    Clone
    Products:
         
    OriGene clones in human, mouse for ZEB1 (see all 29)
    OriGene ORF clones in mouse, rat for ZEB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): ZEB1 (NM_001128128)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZEB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZEB1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ZEB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZEB1
      QuantiTect SYBR Green Assays in human, mouse, rat ZEB1
      QuantiFast Probe-based Assays in human, mouse, rat ZEB1

    Additional mRNA sequence: 

    AK091478.1 AK294775.1 AK296244.1 AK299541.1 AK299666.1 AK300830.1 AK307510.1 AK308785.1 
    AK308822.1 AK309331.1 AK309399.1 AK310924.1 AK311116.1 AK311137.1 AK311187.1 AK311201.1 
    AK311372.1 AK311557.1 AK314683.1 AL831979.1 BC009572.1 BC065705.1 BC107781.1 BC112392.1 
    BX647794.1 M81699.1 U12170.1 

    16 DOTS entries:

    DT.99982248  DT.92436781  DT.100794496  DT.95070818  DT.95070805  DT.100794497  DT.121247574  DT.95264874 
    DT.100794498  DT.100805122  DT.121247548  DT.121247629  DT.92436780  DT.95136334  DT.40296564  DT.92436784 

    Selected AceView cDNA sequences (see all 224):

    AA490600 AI127858 BE157460 AI869991 BE669417 AA256912 AL831979 BE464846 
    BX471860 BC009572 BM719036 AA911736 AI655916 AI052067 AW085067 AA447846 
    D57587 BQ003893 BQ888755 AI367546 BU517351 AI591345 AA255488 BQ009469 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZEB1 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:        -           -     -                                                                           
    SP2:                          -           -                                                               
    SP3:                          -     -     -     -     -                                                   
    SP4:                          -     -     -     -     -           -                                       
    SP5:                    -     -           -                                                               


    ECgene alternative splicing isoforms for ZEB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZEB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCATTTTCT
    ZEB1 Expression
    About this image


    ZEB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
             S-shaped Body
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Endothelial Cells Corneal Endothelium
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             pre Conventional Dendritic Cells Peripheral Blood
    ZEB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZEB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.124503

    UniProtKB/Swiss-Prot: ZEB1_HUMAN, P37275
    Tissue specificity: Colocalizes with SMARCA4/BRG1 in E-cadherin-negative cells from established lines, and stroma
    of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas
    (at protein level). Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ZEB1: 
              T Helper Cell Differentiation in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZEB1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zeb11 , 5 zinc finger E-box binding homeobox 11, 5 85.94(n)1
    88.09(a)1
      18 (4.42 cM)5
    214171  NM_011546.31  NP_035676.11 
     55918605 
    chicken
    (Gallus gallus)
    Aves ZEB11 zinc finger E-box binding homeobox 1 83.17(n)
    85.35(a)
      396029  NM_205131.1  NP_990462.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZEB16
    zinc finger E-box binding homeobox 1
    81(a)
    1 ↔ 1
    6(12786118-12808207)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia zeb11 zinc finger E-box binding homeobox 1 75.25(n)
    78.76(a)
      548525  NM_001015808.1  NP_001015808.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zfhx12 zinc finger homeobox 1 76.62(n)   114425  AB016799.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F58G1.26
    tra-46
    Protein TRA-4 (tra-4) mRNA, complete cds
    17(a)
    14(a)
    many ↔ many
    many ↔ many
    II(12915434-12919018) WBGene00010264
    X(2853678-2857603) WBGene00018740


    ENSEMBL Gene Tree for ZEB1 (if available)
    TreeFam Gene Tree for ZEB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZEB1 gene
    ZNF3242  ZNF324B2  ZEB22  
    Selected SIMAP similar genes for ZEB1 using alignment to 11 protein entries:     ZEB1_HUMAN (see all proteins) (see all similar genes):
    HZF40    ZFS-5    smap-7    ZFHX1B    ZNF22    ZEB2
    DKFZp686M04222    A-328A3.4    ZNF72    ZNF138    ZNF468    zf30
    ZNF78L1    kr-znf3    ZNF323    ZFS-2    ZNF55    ZNF

    ZEB1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZEB1 (see all 3025)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs801945311,2,,4
    C,FCorneal dystrophy, Fuchs endothelial, 6 (FECD6)4 pathogenic131750140(+) AGGGAA/CTGCTA 11 N T mis1 int13Minor allele frequency- C:0.02WA NA EU 5977
    rs1180209011,2,,4
    C,FCorneal dystrophy, Fuchs endothelial, 6 (FECD6)4 pathogenic131810782(+) TCCCCA/CGGTGG 12 Q P mis13Minor allele frequency- C:0.00NA EU 5993
    VAR_0637634
    Corneal dystrophy, Fuchs endothelial, 6 (FECD6)4--see VAR_0637632 A T mis40--------
    VAR_0637614
    Corneal dystrophy, Fuchs endothelial, 6 (FECD6)4--see VAR_0637612 Q P mis40--------
    VAR_0637604
    Corneal dystrophy, Fuchs endothelial, 6 (FECD6)4--see VAR_0637602 P A mis40--------
    rs1456716081,2
    --31328582(+) CTCCCC/TGCCCC 2 -- us2k10--------
    rs78965971,2
    A--31648263(+) TAAAAG/TGAGAA 6 -- int10--------
    rs78966891,2
    A--31648275(+) TCTTAG/TGTGTT 6 -- int10--------
    rs79112751,2
    A,H--31648310(+) AAGAGA/GGGGAA 6 -- int1 trp34Minor allele frequency- G:0.00NS EA 416
    rs1472006221,2
    C--31648445(+) GTTAAC/TACAGG 6 -- int10--------

    HapMap Linkage Disequilibrium report for ZEB1 (31607424 - 31818742 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZEB1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831826CNV Loss17160897
    nsv831824CNV Loss17160897

    Human Gene Mutation Database (HGMD): ZEB1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZEB1
    DNA2.0 Custom Variant and Variant Library Synthesis for ZEB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 189909   
    OMIM disorders: 609141  613270  
    UniProtKB/Swiss-Prot: ZEB1_HUMAN, P37275
  • Corneal dystrophy, posterior polymorphous, 3 (PPCD3) [MIM:609141]: A subtype of posterior corneal
    dystrophy, a disease characterized by alterations of Descemet membrane presenting as vesicles, opacities or
    band-like lesions on slit-lamp examination and specular microscopy. Affected patient typically are asymptomatic.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Corneal dystrophy, Fuchs endothelial, 6 (FECD6) [MIM:613270]: A corneal disease caused by loss of
    endothelium of the central cornea. It is characterized by focal wart-like guttata that arise from Descemet
    membrane and develop in the central cornea, epithelial blisters, reduced vision and pain. Descemet membrane is
    thickened by abnormal collagenous deposition. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • Selected diseases for ZEB1 (see all 51):    
    About MalaCards
    corneal dystrophy, posterior polymorphous, 3    corneal dystrophy, fuchs endothelial, 6    posterior polymorphous corneal dystrophy    corneal dystrophy, hereditary polymorphous posterior
    corneal dystrophy    corneal dystrophy fuchs endothelial 1    hypospadias    congenital hypothyroidism
    gallbladder cancer    malignant pleural mesothelioma    endotheliitis    hypothyroidism
    adult t-cell leukemia    lung squamous cell carcinoma    malignant mesothelioma    leiomyoma
    fanconi's anemia    gastric adenocarcinoma    t-cell leukemia    glaucoma


    ZEB1 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for ZEB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    posterior polymorphous corneal dystrophy 92 6 17935237 (2), 20036349 (1), 18172091 (1), 17437275 (1) (see all 5)
    epithelial tumor 30.7 1 16585218 (1)
    cancer 26.1 8 19011757 (1), 20160487 (1), 11432806 (1), 18622689 (1) (see all 7)
    colon carcinoma 21.1 4 16804902 (2), 11432806 (1)
    tumors 20.6 14 12161443 (2), 19802011 (2), 16585218 (2), 16804902 (2) (see all 6)
    colon cancer 15.9 4 16203744 (3), 16804902 (1)

    Genetic Association Database (GAD): ZEB1
    Human Genome Epidemiology (HuGE) Navigator: ZEB1 (4 documents)

    Export disorders for ZEB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZEB1 gene, integrated from 10 sources (see all 199):
    (articles sorted by number of sources associating them with ZEB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in TCF8 cause posterior polymorphous corneal dystrophy and ectopic expression of COL4A3 by corneal endothelial cells. (PubMed id 16252232)1, 2, 3, 9 Krafchak C.M....Richards J.E. (Am. J. Hum. Genet. 2005)
    2. Identification of a zinc finger protein that inhibits IL-2 gene expression. (PubMed id 1840704)1, 2, 3 Williams T.M.... Kant J.A. (Science 1991)
    3. Posterior polymorphous corneal dystrophy is associated with TCF8 gene mutations and abdominal hernia. (PubMed id 17935237)1, 4, 9 Aldave A.J....Richards J.E. (Am. J. Med. Genet. A 2007)
    4. Analysis of the posterior polymorphous corneal dystrophy 3 gene, TCF8, in late-onset Fuchs endothelial corneal dystrophy. (PubMed id 18172091)1, 4, 9 Mehta J.S....Aung T. (amp 2008)
    5. The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2. (PubMed id 1427828)1, 3, 9 Williams T.M....Shows T.B. (Genomics 1992)
    6. Missense mutations in TCF8 cause late-onset Fuchs corneal dystrophy and interact with FCD4 on chromosome 9p. (PubMed id 20036349)1, 2, 9 Riazuddin S.A.... Katsanis N. (Am. J. Hum. Genet. 2010)
    7. ZEB1 and CtBP form a repressive complex at a distal promoter element of the BCL6 locus. (PubMed id 20175752)1, 2 Papadopoulou V....Wagner S.D. (Biochem. J. 2010)
    8. ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1. (PubMed id 20418909)1, 2 Sanchez-Tillo E.... Postigo A. (Oncogene 2010)
    9. The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. (PubMed id 19935649)1, 2 Wellner U.... Brabletz T. (Nat. Cell Biol. 2009)
    10. KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise. (PubMed id 18984674)1, 4 Argyropoulos G....Rankinen T. (Physiol. Genomics 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6935 HGNC: 11642 AceView: TCF8 Ensembl:ENSG00000148516 euGenes: HUgn6935
    ECgene: ZEB1 Kegg: 6935 H-InvDB: ZEB1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZEB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZEB1 gene:
    Search GeneIP for patents involving ZEB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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