ZEB1 Gene
protein-coding GIFtS: 57
GCID: GC10P031648
|
|
zinc finger E-box binding homeobox 1(Previous names: transcription factor 8 (represses interleukin 2 expression),...)
(Previous symbols: TCF8, PPCD3)
| |
Aliases
for ZEB1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger E-Box Binding Homeobox 11 2 | | Zfhep1 | | TCF81 2 3 5 | | Zfhx1a1 | | AREB61 2 3 | | DELTAEF12 | | PPCD31 2 5 | | ZFHEP2 | | BZP1 2 | | ZFHX1A2 | | Posterior Polymorphous Corneal Dystrophy 31 2 | | Delta-Crystallin Enhancer Binding Factor 12 | | Transcription Factor 8 (Represses Interleukin 2 Expression)1 2 | | Zinc Finger E-Box-Binding Homeobox 12 | | Negative Regulator Of IL22 3 | | Zinc Finger Homeodomain Enhancer-Binding Protein2 | | FECD62 5 | | TCF-83 | | NIL2A2 5 | | NIL-2-A Zinc Finger Protein3 | | NIL-2-A1 | | Transcription Factor 83 | | ZEB1 | | |
Export aliases for ZEB1 gene to outside databasesPrevious GC identifer: GC10P031330 |
Summaries
for ZEB1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZEB1:
This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptionalrepression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous cornealdystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encodingdifferent isoforms have been described.(provided by RefSeq, Mar 2010)
UniProtKB/Swiss-Prot: ZEB1_HUMAN, P37275Function: Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses thepromoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherinpromoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotestumorigenicity by repressing stemness-inhibiting microRNAs
Gene Wiki entry for ZEB1
|
Genomic Views
for ZEB1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_008705.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZEB1 gene promoter:
AREB6 MyoD
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZEB1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZEB1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10p11.2 Ensembl cytogenetic band: 10p11.22 HGNC cytogenetic band: 10p11.22ZEB1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P031648: view genomic region
(about GC identifiers)
Start:
|
31,607,424 bp from pter |
End:
|
31,818,742 bp from pter |
Size:
|
211,319 bases |
Orientation:
|
plus strand |
|
Proteins
for ZEB1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZEB1_HUMAN, P37275 (See
protein sequence)Recommended Name: Zinc finger E-box-binding homeobox 1 Size: 1124 amino acids; 124074 Da
Subunit: Interacts (via N-terminus) with SMARCA4/BRG1
Subcellular location: Nucleus
1 PDB 3D structure from  and Proteopedia  for ZEB1:2E19 (3D)
Secondary accessions: Q12924 Q13800 Q2KJ05 Q5T968Alternative splicing: 2 isoforms: P37275-1 P37275-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZEB1: NX_P37275
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P37275
ZEB1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (6 alternative transcripts):
NP_001121600.1 NP_001167564.1 NP_001167565.1 NP_001167566.1 NP_001167567.1 NP_110378.3
ENSEMBL proteins: ENSP00000452784 ENSP00000453073 ENSP00000444282 ENSP00000453258 ENSP00000319248 ENSP00000453568 ENSP00000452787 ENSP00000453970 ENSP00000415961 ENSP00000405958 ENSP00000444891 ENSP00000452703 ENSP00000453559 ENSP00000452868 ENSP00000453823 ENSP00000452612 ENSP00000453674 ENSP00000453874 ENSP00000354487 ENSP00000391612
Human Recombinant Protein Products for ZEB1:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
ZEB1 for ontologies About GeneDecksing
ZEB1 Antibody Products:
Assay Products for ZEB1: |
Protein
Domains /
Families
for ZEB1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZEB1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P37275ProtoNet protein and cluster: P37275 1 Blocks protein family: IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZEB1_HUMAN, P37275Similarity: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger familySimilarity: Contains 7 C2H2-type zinc fingersSimilarity: Contains 1 homeobox DNA-binding domain |
Function
for ZEB1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZEB1_HUMAN, P37275Function: Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses thepromoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherinpromoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotestumorigenicity by repressing stemness-inhibiting microRNAs Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table
ZEB1 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for ZEB1:
15/25 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Zeb1) (see all 25):
ZEB1 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Zeb1tm1Yhi for ZEB1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZEB1 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZEB1 (see all 6)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 6): ZEB1 (NM_001128128) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZEB1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZEB1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZEB1 |
|
Pathways & Interactions
for ZEB1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Diuretics Pathway, Pharmacodynamics | | | 2 | TGF-beta Receptor Signaling Pathway | | | 3 | Wnt / Hedgehog / Notch | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for ZEB1
1  BioSystems Pathway for ZEB1
1  PharmGKB Pathway for ZEB1
ZEB1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZEB1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 18)
5/18 Interacting proteins for ZEB1 (P372752, 3 ENSP000003192484) via UniProtKB, MINT, STRING, and/or I2D (see all 18)About this table
Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26): About this table
ZEB1 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZEB1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ZEB1 for compounds About GeneDecksing
 Browse Tocris compounds for ZEB1
1 HMDB Compound for ZEB1 About this table
2 Novoseek chemical compound relationships for ZEB1 gene About this table
Search CenterWatch for drugs/clinical trials and news about ZEB1
|
Transcripts
for ZEB1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZEB1 gene (6 alternative transcripts): NM_001128128.2 NM_001174093.1 NM_001174094.1 NM_001174095.1 NM_001174096.1 NM_030751.5 Unigene Cluster for ZEB1: Zinc finger E-box binding homeobox 1 Hs.124503 [show with all ESTs]Unigene Representative Sequence: NM_00112812818/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24): ENST00000488625 ENST00000560196 ENST00000542879 ENST00000561304 ENST00000320985(uc009xlj.1 uc010qeg.1 uc009xlk.1)
ENST00000483752 ENST00000559858 ENST00000560721 ENST00000558440 ENST00000424869
ENST00000437844(uc001ivr.4 uc010qef.2 uc009xlh.1 uc009xli.1 uc001ivt.4)
ENST00000542815 ENST00000558863 ENST00000561212 ENST00000558655 ENST00000561061(uc009xll.2)
ENST00000559496(uc009xlm.1 uc009xln.1) ENST00000559476
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZEB1 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZEB1 (see all 6)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 6): ZEB1 (NM_001128128) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZEB1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZEB1 |
Additional cDNA sequence: AK091478.1 AK294775.1 AK296244.1 AK299541.1 AK299666.1 AK300830.1 AK307510.1 AK308785.1 AK308822.1 AK309331.1 AK309399.1 AK310924.1 AK311116.1 AK311137.1 AK311187.1 AK311201.1 AK311372.1 AK311557.1 AK314683.1 AL831979.1 BC009572.1 BC065705.1 BC107781.1 BC112392.1 BX647794.1 M81699.1 U12170.1 16 DOTS entries: DT.99982248 DT.92436781 DT.100794496 DT.95070818 DT.95070805 DT.100794497 DT.121247574 DT.95264874 DT.100794498 DT.100805122 DT.121247548 DT.121247629 DT.92436780 DT.95136334 DT.40296564 DT.92436784 24/224 AceView cDNA sequences (see all 224): AU134735 BP364438 BU631407 AL710239 AA258522 AA400754 CA412312 BM994180 AI264292 AI051560 AA447846 D57587 BQ888755 BQ003893 AI367546 AI591345 BU517351 AA255488 CD675003 BQ009469 BE673922 AA490600 BE157460 AI127858
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZEB1 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 |
|---|
|
| SP1: | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZEB1
|
Expression
for ZEB1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZEB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCATTTTCT
About this image
See ZEB1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZEB1
SOURCE GeneReport for Unigene cluster: Hs.124503
UniProtKB/Swiss-Prot: ZEB1_HUMAN, P37275Tissue specificity: Colocalizes with SMARCA4/BRG1 in E-cadherin-negative cells from established lines, and stroma ofnormal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (atprotein level). Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas
SABiosciences Expression via Pathway-Focused PCR Arrays including ZEB1: | T Helper Cell Differentiation in human mouse rat | | Epithelial to Mesenchymal Transition (EMT) in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZEB1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZEB1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZEB1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZEB1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZEB1 |
Orthologs
for ZEB1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZEB1 gene from 6/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Zeb11 , 5 |
zinc finger E-box binding homeobox 11, 5 |
85.88(n)1
88.55(a)1 |
|
18 (4.42 cM)5
214171 NM_011546.31 NP_035676.11
55918605 |
chicken
(Gallus gallus) |
Aves |
ZEB11 |
zinc finger E-box binding homeobox 1 |
83.6(n)
86.33(a) |
|
396029 NM_205131.1 NP_990462.1 |
lizard
(Anolis carolinensis) |
Reptilia |
ZEB16 |
-- |
82(a) |
1 ↔ 1 |
6(12788561-12808207) |
zebrafish
(Danio rerio) |
Actinopterygii |
zfhx12 |
zinc finger homeobox 1 |
76.62(n) |
|
114425 AB016799.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
zfh16 |
Zn finger homeodomain 1 |
21(a) |
1 → many |
3R(26591648-26614205) |
worm
(Caenorhabditis elegans) |
Secernentea |
zag-16 |
Zinc finger plus homeodomain, Axon Guidance family... |
29(a) |
1 → many |
IV(3855837-3861118) |
ENSEMBL Gene Tree for ZEB1 (if available)
TreeFam Gene Tree for ZEB1 (if available) |
Paralogs
for ZEB1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZEB1 gene
- ZEB22
18/58 SIMAP similar genes for ZEB1 using alignment to 21 protein entries: ZEB1_HUMAN (see all proteins)
(see all similar genes):ZNF135 ZNF419 HZF40 ZNF559 ZNF786 ZNF78L1
ZNF26 ZNF417 ZNF460 ZFS-5 smap-7 ZFHX1B
ZNF22 ZEB2 kr-znf3 ZNF692 ZNF782 ZFP69B
ZEB1 for paralogs About GeneDecksing
|
Genomic Variants
for ZEB1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZEB1 (31607424 - 31818742 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZEB1: --
Human Gene Mutation Database (HGMD): ZEB1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZEB1 |
|
Disorders
/ Diseases
for ZEB1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZEB1 for disorders About GeneDecksing
OMIM gene information: 189909
OMIM disorders: 609141 613270
UniProtKB/Swiss-Prot: ZEB1_HUMAN, P37275
Defects in ZEB1 are the cause of posterior polymorphous corneal dystrophy type 3 (PPCD3) [MIM:609141]. PPCD isa rare disease involving metaplasia and overgrowth of corneal endothelial cells. In patients with PPCD, these cellsmanifest in an epithelial morphology and gene expression pattern, produce an aberrant basement membrane, and,sometimes, spread over the iris and nearby structures in a way that increases the risk for glaucoma Defects in ZEB1 are the cause of corneal dystrophy Fuchs endothelial type 6 (FECD6) [MIM:613270]. It is anocular disorder caused by loss of endothelium of the central cornea. It is characterized by focal wart-like guttatathat arise from Descemet membrane and develop in the central cornea, epithelial blisters, reduced vision and pain.Descemet membrane is thickened by abnormal collagenous deposition
20/39  diseases for ZEB1 (see all 39): About MalaCardsposterior polymorphous corneal dystrophy corneal dystrophy corneal dystrophy, fuchs endothelial, 6 corneal dystrophy, posterior polymorphous, 3
systemic lupus erythematosus lupus erythematosus adult t-cell leukemia congenital hypothyroidism
fanconi's anemia leukemia/lymphoma hypothyroidism squamous cell carcinoma
glaucoma colon carcinoma gallbladder cancer t-cell leukemia
hernia colon cancer endometrial cancer anemia
6 Novoseek disease relationships for ZEB1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| posterior polymorphous corneal dystrophy |
92 |
6 |
17935237 (2), 20036349 (1), 18172091 (1), 17437275 (1) (see all 5) |
| epithelial tumor |
30.7 |
1 |
16585218 (1) |
| cancer |
26.1 |
8 |
19011757 (1), 20160487 (1), 11432806 (1), 18622689 (1) (see all 7) |
| colon carcinoma |
21.1 |
4 |
16804902 (2), 11432806 (1) |
| tumors |
20.6 |
14 |
12161443 (2), 19802011 (2), 16585218 (2), 16804902 (2) (see all 6) |
| colon cancer |
15.9 |
4 |
16203744 (3), 16804902 (1) |
Human Genome Epidemiology (HuGE) Navigator: ZEB1 (4 documents)
Export disorders for ZEB1 gene to outside databases
|
Publications
for ZEB1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZEB1 gene, integrated from 9 sources (see all 166):
(articles sorted by number of sources associating them with ZEB1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mutations in TCF8 cause posterior polymorphous corneal dystrophy and ectopic expression of COL4A3 by corneal endothelial cells. (PubMed id 16252232)1, 2, 3, 9 Krafchak C.M....Richards J.E. (2005)
- Identification of a zinc finger protein that inhibits IL-2 gene expression. (PubMed id 1840704)1, 2, 3 Williams T.M.... Kant J.A. (1991)
- The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2. (PubMed id 1427828)1, 3, 9 Williams T.M....Shows T.B. (1992)
- Missense mutations in TCF8 cause late-onset Fuchs cor neal dystrophy and interact with FCD4 on chromosome 9p. (PubMed id 20036349)1, 2, 9 Riazuddin S.A....Katsanis N. (2010)
- ZEB1 and CtBP form a repressive complex at a distal p romoter element of the BCL6 locus. (PubMed id 20175752)1, 2 Papadopoulou V....Wagner S.D. (2010)
- ZEB1 represses E-cadherin and induces an EMT by recru iting the SWI/SNF chromatin-remodeling protein BRG1. (PubMed id 20418909)1, 2 SA!nchez-TillA^ E....Postigo A. (2010)
- The EMT-activator ZEB1 promotes tumorigenicity by rep ressing stemness-inhibiting microRNAs. (PubMed id 19935649)1, 2 Wellner U....Brabletz T. (2009)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin. (PubMed id 16061479)1, 2 Long J.... Park M. (2005)
- A locus for posterior polymorphous corneal dystrophy (PPCD3) maps to chromosome 10. (PubMed id 15384081)1, 3 Shimizu S....Richards J.E. (2004)
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External Searches for ZEB1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing ZEB1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing ZEB1 gene
(According to HUGE)
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Specialized Databases showing ZEB1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for ZEB1 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for ZEB1 gene:
Search GeneIP for patents involving ZEB1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for ZEB1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | OriGene Antibodies for ZEB1 | | OriGene shRNA RFP for ZEB1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZEB1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZEB1 | | | OriGene Protein Over-expression Lysate for ZEB1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZEB1 | | OriGene 3'-UTR Clone for ZEB1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZEB1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZEB1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZEB1 | | OriGene Custom Protein Services for ZEB1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZEB1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZEB1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZEB1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZEB1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZEB1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZEB1 |
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| | Antibodies & Assays for ZEB1 (TCF8) |
| | | | Search Tocris compounds for ZEB1 |
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 | | | ZEB1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZEB1 |
|  |  |  |  | | | | ThermoFisher Antibodies for ZEB1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZEB1 |
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