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Aliases for ZDHHC9 Gene

Aliases for ZDHHC9 Gene

  • Zinc Finger, DHHC-Type Containing 9 2 3
  • DHHC9 3 4 6
  • Zinc Finger Protein 379 3 4
  • Zinc Finger Protein 380 3 4
  • CXorf11 3 4
  • ZDHHC10 3 4
  • ZNF379 3 4
  • ZNF380 3 4
  • MRXSZ 3 6
  • Zinc Finger DHHC Domain-Containing Protein 9 4
  • Asp-His-His-Cys Domain Containing Protein 9 3
  • Zinc Finger, DHHC Domain Containing 10 3
  • Zinc Finger, DHHC-Type Containing 10 2
  • Chromosome X Open Reading Frame 11 2
  • Palmitoyltransferase ZDHHC9 3
  • Antigen MMSA-1 3
  • EC 4
  • EC 63
  • EC 2.3.1 63
  • DHHC-9 4
  • CGI89 3
  • MMSA1 3

External Ids for ZDHHC9 Gene

Previous HGNC Symbols for ZDHHC9 Gene

  • ZDHHC10
  • CXorf11

Previous GeneCards Identifiers for ZDHHC9 Gene

  • GC0XM123585
  • GC0XM125785
  • GC0XM126883
  • GC0XM127645
  • GC0XM128664
  • GC0XM128766
  • GC0XM128938
  • GC0XM118338

Summaries for ZDHHC9 Gene

Entrez Gene Summary for ZDHHC9 Gene

  • This gene encodes an integral membrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein forms a complex with golgin subfamily A member 7 and functions as a palmitoyltransferase. This protein specifically palmitoylates HRAS and NRAS. Mutations in this gene are associated with X-linked mental retardation. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, May 2010]

GeneCards Summary for ZDHHC9 Gene

ZDHHC9 (Zinc Finger, DHHC-Type Containing 9) is a Protein Coding gene. Diseases associated with ZDHHC9 include mental retardation, x-linked syndromic, raymond type. GO annotations related to this gene include transferase activity, transferring acyl groups. An important paralog of this gene is ZDHHC4.

UniProtKB/Swiss-Prot for ZDHHC9 Gene

  • The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS.

Gene Wiki entry for ZDHHC9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC9 Gene

Genomics for ZDHHC9 Gene

Regulatory Elements for ZDHHC9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZDHHC9 Gene

129,803,288 bp from pter
129,843,934 bp from pter
40,647 bases
Minus strand

Genomic View for ZDHHC9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZDHHC9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC9 Gene

Proteins for ZDHHC9 Gene

  • Protein details for ZDHHC9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Palmitoyltransferase ZDHHC9
    Protein Accession:
    Secondary Accessions:
    • B4F6G2
    • D3DTF9
    • Q59EK4
    • Q5JSW5
    • Q8WWS7
    • Q9BPY4
    • Q9NSP0
    • Q9NVL0
    • Q9NVR6

    Protein attributes for ZDHHC9 Gene

    364 amino acids
    Molecular mass:
    40916 Da
    Quaternary structure:
    • Interacts with GOLGA7.
    • Sequence=AAD34084.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91683.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD93044.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB82308.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZDHHC9 Gene

Proteomics data for ZDHHC9 Gene at MOPED

Post-translational modifications for ZDHHC9 Gene

  • Ubiquitination at Lys127
  • Modification sites at PhosphoSitePlus

Other Protein References for ZDHHC9 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ZDHHC9

Domains for ZDHHC9 Gene

Gene Families for ZDHHC9 Gene

  • ZDHHC :Zinc fingers, DHHC-type

Protein Domains for ZDHHC9 Gene

Suggested Antigen Peptide Sequences for ZDHHC9 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9Y397
  • The DHHC domain is required for palmitoyltransferase activity
  • Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
  • Contains 1 DHHC-type zinc finger.
genes like me logo Genes that share domains with ZDHHC9: view

Function for ZDHHC9 Gene

Molecular function for ZDHHC9 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA
UniProtKB/Swiss-Prot Function:
The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS.

Enzyme Numbers (IUBMB) for ZDHHC9 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016409 palmitoyltransferase activity IDA 23034182
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
GO:0043849 Ras palmitoyltransferase activity IDA 16000296
genes like me logo Genes that share ontologies with ZDHHC9: view

Phenotypes for ZDHHC9 Gene

GenomeRNAi human phenotypes for ZDHHC9:
genes like me logo Genes that share phenotypes with ZDHHC9: view

Animal Model Products

miRNA for ZDHHC9 Gene

miRTarBase miRNAs that target ZDHHC9

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZDHHC9

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ZDHHC9 Gene

Localization for ZDHHC9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC9 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ZDHHC9 Gene COMPARTMENTS Subcellular localization image for ZDHHC9 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
cytosol 3
plasma membrane 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ZDHHC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002178 palmitoyltransferase complex IDA 16000296
GO:0005737 cytoplasm IDA --
GO:0005783 endoplasmic reticulum IDA 16000296
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with ZDHHC9: view

Pathways for ZDHHC9 Gene

SuperPathways for ZDHHC9 Gene

No Data Available

Interacting Proteins for ZDHHC9 Gene

Gene Ontology (GO) - Biological Process for ZDHHC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0018230 peptidyl-L-cysteine S-palmitoylation IDA 16000296
GO:0018345 protein palmitoylation IDA 23034182
genes like me logo Genes that share ontologies with ZDHHC9: view

No data available for Pathways by source for ZDHHC9 Gene

Transcripts for ZDHHC9 Gene

Unigene Clusters for ZDHHC9 Gene

Zinc finger, DHHC-type containing 9:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZDHHC9

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC9 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - - -
SP2: - - - - - - - -
SP3: - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - -

Relevant External Links for ZDHHC9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZDHHC9 Gene

mRNA expression in normal human tissues for ZDHHC9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ZDHHC9 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZDHHC9 Gene

SOURCE GeneReport for Unigene cluster for ZDHHC9 Gene Hs.193566

mRNA Expression by UniProt/SwissProt for ZDHHC9 Gene

Tissue specificity: Highly expressed in kidney, skeletal muscle, brain, lung and liver. Absent in thymus, spleen and leukocytes.
genes like me logo Genes that share expressions with ZDHHC9: view

Expression partners for ZDHHC9 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ZDHHC9 Gene

Orthologs for ZDHHC9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZDHHC9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZDHHC9 35
  • 94.49 (n)
  • 97.52 (a)
  • 98 (a)
(Canis familiaris)
Mammalia ZDHHC9 35
  • 94.78 (n)
  • 98.08 (a)
  • 98 (a)
(Mus musculus)
Mammalia Zdhhc9 35
  • 93.41 (n)
  • 98.35 (a)
Zdhhc9 16
Zdhhc9 36
  • 98 (a)
(Pan troglodytes)
Mammalia ZDHHC9 35
  • 90.15 (n)
  • 87.16 (a)
(Rattus norvegicus)
Mammalia Zdhhc9 35
  • 92.67 (n)
  • 98.35 (a)
(Monodelphis domestica)
Mammalia ZDHHC9 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia ZDHHC9 36
  • 87 (a)
(Gallus gallus)
Aves ZDHHC9 35
  • 79.04 (n)
  • 89.47 (a)
  • 83 (a)
(Anolis carolinensis)
Reptilia ZDHHC9 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12060 35
zdhhc9 35
  • 74.41 (n)
  • 85.29 (a)
(Danio rerio)
Actinopterygii zdhhc9 35
  • 71.52 (n)
  • 79.39 (a)
zdhhc9 36
  • 70 (a)
fruit fly
(Drosophila melanogaster)
Insecta app 36
  • 25 (a)
(Caenorhabditis elegans)
Secernentea Y47H9C.2 37
  • 46 (a)
dhhc-2 36
  • 34 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL125C 35
  • 45.55 (n)
  • 33.59 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D18370g 35
  • 45.74 (n)
  • 37.22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERF2 35
  • 43.18 (n)
  • 33.33 (a)
ERF2 38
(Oryza sativa)
Liliopsida Os11g0534300 35
  • 52.33 (n)
  • 42.66 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02015 35
  • 41 (n)
  • 36.78 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3762 36
  • 50 (a)
Species with no ortholog for ZDHHC9:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC9 Gene

Gene Tree for ZDHHC9 (if available)
Gene Tree for ZDHHC9 (if available)

Paralogs for ZDHHC9 Gene

Selected SIMAP similar genes for ZDHHC9 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZDHHC9: view

Variants for ZDHHC9 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC9 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs11990 -- 129,805,719(-) TAAGT(A/G)GTTGT utr-variant-3-prime
rs13525 -- 129,803,630(+) CTCAC(A/T)CCTGG utr-variant-3-prime
rs1053440 -- 129,806,265(-) TTTAA(C/T)TGTTT utr-variant-3-prime
rs1053486 -- 129,804,982(-) AAACC(A/G)GAACT utr-variant-3-prime
rs1053487 -- 129,804,968(-) CATCT(A/C/T)TTTGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC9 Gene

Variant ID Type Subtype PubMed ID
dgv2475e1 CNV Complex 17122850
nsv528290 CNV Gain 19592680
nsv526197 CNV Gain 19592680
nsv7087 CNV Loss 18451855

Relevant External Links for ZDHHC9 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC9 Gene

Disorders for ZDHHC9 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ZDHHC9 Gene in MalaCards »

(1) Diseases for ZDHHC9 Gene including...

(1) OMIM Diseases for ZDHHC9 Gene (300646)


  • Mental retardation, X-linked, syndromic, ZDHHC9-related (MRXSZ) [MIM:300799]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Some MRXSZ patients have marfanoid habitus as an additional feature. {ECO:0000269 PubMed:17436253, ECO:0000269 PubMed:19377476}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with ZDHHC9: view

No data available for University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ZDHHC9 Gene

Publications for ZDHHC9 Gene

  1. DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras. (PMID: 16000296) Swarthout J.T. … Linder M.E. (J. Biol. Chem. 2005) 3 4 23
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  3. Differential expression of DHHC9 in microsatellite stable and instable human colorectal cancer subgroups. (PMID: 17519897) Mansilla F. … Orntoft T.F. (Br. J. Cancer 2007) 3 23
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for ZDHHC9 Gene

Sources for ZDHHC9 Gene

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