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Aliases for ZDHHC8 Gene

Aliases for ZDHHC8 Gene

  • Zinc Finger DHHC-Type Containing 8 2 3 5
  • Zinc Finger Protein 378 3 4
  • ZDHHCL1 3 4
  • ZNF378 3 4
  • Membrane-Associated DHHC8 Zinc Finger Protein 3
  • Zinc Finger DHHC Domain-Containing Protein 8 4
  • Zinc Finger, DHHC Domain Like Containing 1 3
  • Probable Palmitoyltransferase ZDHHC8 3
  • EC 4
  • KIAA1292 4
  • EC 2.3.1 58
  • DHHC-8 4
  • DHHC8 3

External Ids for ZDHHC8 Gene

Previous GeneCards Identifiers for ZDHHC8 Gene

  • GC22P017059
  • GC22P018494
  • GC22P018493
  • GC22P018499
  • GC22P020116
  • GC22P003740

Summaries for ZDHHC8 Gene

Entrez Gene Summary for ZDHHC8 Gene

  • This gene encodes a four transmembrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein may function as a palmitoyltransferase. Defects in this gene may be associated with a susceptibility to schizophrenia. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 22.[provided by RefSeq, May 2010]

GeneCards Summary for ZDHHC8 Gene

ZDHHC8 (Zinc Finger DHHC-Type Containing 8) is a Protein Coding gene. Diseases associated with ZDHHC8 include Schizophrenia and Velocardiofacial Syndrome. Among its related pathways are Metabolism and Lipoprotein metabolism. GO annotations related to this gene include receptor activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC5.

UniProtKB/Swiss-Prot for ZDHHC8 Gene

  • Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1.

Gene Wiki entry for ZDHHC8 Gene

Additional gene information for ZDHHC8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC8 Gene

Genomics for ZDHHC8 Gene

Regulatory Elements for ZDHHC8 Gene

Enhancers for ZDHHC8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H020494 1.8 FANTOM5 ENCODE dbSUPER 28.5 +366.4 366388 2.7 FEZF1 YBX1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 ZC3H11A MEF2D LZTR1 DGCR8 MED15 RPL7AP70 TRMT2A LOC100420177 RPL8P5 THAP7-AS1 THAP7 ENSG00000273343
GH22H019217 1.3 Ensembl ENCODE 30.5 -910.9 -910920 1.1 ATF1 ARNT FEZF1 ZNF2 TCF12 ZNF121 GATA2 ATF7 ZC3H11A REST DGCR8 LINC01311 SLC25A1 TRMT2A ENSG00000273300 ZDHHC8 RPL7AP70 CLTCL1 RPL8P5 DGCR11
GH22H019947 1.9 FANTOM5 Ensembl ENCODE dbSUPER 20.3 -178.7 -178733 7.3 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B FEZF1 DMAP1 ZNF2 CBX5 DGCR8 TRMT2A LOC100420177 LINC01311 RPL8P5 ENSG00000273300 MED15 DGCR11 RPL7AP70 ZDHHC8
GH22H019760 1.8 VISTA Ensembl ENCODE 20.6 -365.1 -365133 8.3 HDGF PKNOX1 ATF1 FOXA2 ARNT ZNF2 TCF12 GATA2 FOS ATF7 LINC01311 DGCR8 LOC100420177 TRMT2A ZDHHC8 RANBP1 RPL8P5 KLHL22 UFD1 ABHD17AP4
GH22H020961 1.2 Ensembl ENCODE 30.5 +832.5 832532 0.9 HDGF PKNOX1 ARNT ZFP64 ARID4B YBX1 ZNF143 ZC3H11A REST ZNF623 DGCR8 LZTR1 THAP7 THAP7-AS1 TRMT2A PPIL2 ZDHHC8 CCDC116 LOC100420177 PI4KAP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZDHHC8 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZDHHC8 Gene

Genomic Locations for ZDHHC8 Gene
18,552 bases
Plus strand

Genomic View for ZDHHC8 Gene

Genes around ZDHHC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC8 Gene

Proteins for ZDHHC8 Gene

  • Protein details for ZDHHC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable palmitoyltransferase ZDHHC8
    Protein Accession:
    Secondary Accessions:
    • Q2TGE9
    • Q6ICL1
    • Q6ZNF5
    • Q7Z6L9

    Protein attributes for ZDHHC8 Gene

    765 amino acids
    Molecular mass:
    81443 Da
    Quaternary structure:
    No Data Available
    • According to PubMed:15489219 and PubMed:15184899, defects in ZDHHC8 may contribute to susceptibility to schizophrenia, but according to PubMed:15992527, PubMed:15631889 and PubMed:16150541, it is not the case.
    • Sequence=BAD18420.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAG30243.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZDHHC8 Gene


neXtProt entry for ZDHHC8 Gene

Selected DME Specific Peptides for ZDHHC8 Gene


Post-translational modifications for ZDHHC8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZDHHC8 Gene

Domains & Families for ZDHHC8 Gene

Gene Families for ZDHHC8 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for ZDHHC8 Gene

Suggested Antigen Peptide Sequences for ZDHHC8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
genes like me logo Genes that share domains with ZDHHC8: view

Function for ZDHHC8 Gene

Molecular function for ZDHHC8 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
UniProtKB/Swiss-Prot Function:
Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1.

Enzyme Numbers (IUBMB) for ZDHHC8 Gene

Phenotypes From GWAS Catalog for ZDHHC8 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016409 palmitoyltransferase activity IDA 23034182
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity TAS --
genes like me logo Genes that share ontologies with ZDHHC8: view
genes like me logo Genes that share phenotypes with ZDHHC8: view

Animal Models for ZDHHC8 Gene

MGI Knock Outs for ZDHHC8:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZDHHC8 Gene

Localization for ZDHHC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC8 Gene

Cytoplasmic vesicle membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC8 gene
Compartment Confidence
golgi apparatus 5
cytosol 4
mitochondrion 3
plasma membrane 2
extracellular 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZDHHC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005794 Golgi apparatus IDA 16647879
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC8: view

Pathways & Interactions for ZDHHC8 Gene

genes like me logo Genes that share pathways with ZDHHC8: view

Interacting Proteins for ZDHHC8 Gene

Gene Ontology (GO) - Biological Process for ZDHHC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007626 locomotory behavior IEA --
GO:0018345 protein palmitoylation IDA 23034182
GO:0034380 high-density lipoprotein particle assembly TAS --
GO:1903146 regulation of mitophagy IMP 24912190
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24912190
genes like me logo Genes that share ontologies with ZDHHC8: view

No data available for SIGNOR curated interactions for ZDHHC8 Gene

Drugs & Compounds for ZDHHC8 Gene

(1) Drugs for ZDHHC8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for ZDHHC8 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZDHHC8: view

Transcripts for ZDHHC8 Gene

Unigene Clusters for ZDHHC8 Gene

Zinc finger, DHHC-type containing 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC8 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP5: - - - - - - - -
SP6: -
SP7: - -

Relevant External Links for ZDHHC8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZDHHC8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZDHHC8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZDHHC8 Gene

This gene is overexpressed in Plasma (52.4) and Heart (14.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZDHHC8 Gene

Protein tissue co-expression partners for ZDHHC8 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZDHHC8 Gene:


SOURCE GeneReport for Unigene cluster for ZDHHC8 Gene:


Evidence on tissue expression from TISSUES for ZDHHC8 Gene

  • Nervous system(4.6)
  • Blood(4.2)
genes like me logo Genes that share expression patterns with ZDHHC8: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC8 Gene

Orthologs for ZDHHC8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZDHHC8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZDHHC8 33 34
  • 97.37 (n)
(Canis familiaris)
Mammalia ZDHHC8 33 34
  • 89.54 (n)
(Ornithorhynchus anatinus)
Mammalia ZDHHC8 34
  • 89 (a)
(Rattus norvegicus)
Mammalia Zdhhc8 33
  • 86.09 (n)
(Mus musculus)
Mammalia Zdhhc8 33 16 34
  • 85.7 (n)
(Bos Taurus)
Mammalia ZDHHC8 34
  • 74 (a)
(Monodelphis domestica)
Mammalia ZDHHC8 34
  • 54 (a)
(Gallus gallus)
Aves ZDHHC8 33 34
  • 67.19 (n)
(Anolis carolinensis)
Reptilia ZDHHC8 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc8 33
  • 63.79 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32325 33
(Danio rerio)
Actinopterygii zdhhc8b 33 34
  • 61.6 (n)
zdhhc5 33
fruit fly
(Drosophila melanogaster)
Insecta CG34449 34
  • 25 (a)
(Caenorhabditis elegans)
Secernentea dhhc-8 34
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
Species where no ortholog for ZDHHC8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC8 Gene

Gene Tree for ZDHHC8 (if available)
Gene Tree for ZDHHC8 (if available)

Paralogs for ZDHHC8 Gene

Paralogs for ZDHHC8 Gene

(6) SIMAP similar genes for ZDHHC8 Gene using alignment to 3 proteins: Pseudogenes for ZDHHC8 Gene

genes like me logo Genes that share paralogs with ZDHHC8: view

Variants for ZDHHC8 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC8 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs193920775 Uncertain significance 20,141,427(+) GAGTG(A/C/T)CCTGT reference, missense
rs1000007222 -- 20,132,581(+) CTTGG(C/T)CTCCT intron-variant
rs1000133423 -- 20,130,948(+) ACCTA(-/TAG)GGGAG upstream-variant-2KB
rs1000375308 -- 20,146,056(+) GCGCC(A/G)TGTCT intron-variant, utr-variant-3-prime
rs1000461423 -- 20,130,665(+) TACGG(C/T)TGCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC8 Gene

Variant ID Type Subtype PubMed ID
dgv4480n100 CNV gain 25217958
dgv4481n100 CNV gain 25217958
dgv726n67 CNV gain 20364138
dgv7983n54 CNV gain 21841781
esv2758825 CNV loss 17122850
esv3647284 CNV gain 21293372
nsv953027 CNV deletion 24416366
nsv834134 CNV loss 17160897
nsv834133 CNV loss 17160897
nsv828939 CNV loss 20364138
nsv828938 CNV gain 20364138
nsv588248 CNV loss 21841781
nsv471183 CNV loss 18288195
nsv1112810 CNV deletion 24896259
esv3893434 CNV gain 25118596

Variation tolerance for ZDHHC8 Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.98; 68.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZDHHC8 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC8 Gene

Disorders for ZDHHC8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZDHHC8 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
  • schizophrenia 12
velocardiofacial syndrome
  • cayler cardiofacial syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZDHHC8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZDHHC8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZDHHC8 Gene

Publications for ZDHHC8 Gene

  1. No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples. (PMID: 15992527) Glaser B … Owen MJ (Biological psychiatry 2005) 3 4 22 45 60
  2. Evidence that the gene encoding ZDHHC8 contributes to the risk of schizophrenia. (PMID: 15184899) Mukai J … Gogos JA (Nature genetics 2004) 2 3 4 45 60
  3. Case-control study and transmission disequilibrium test provide consistent evidence for association between schizophrenia and genetic variation in the 22q11 gene ZDHHC8. (PMID: 15489219) Chen WY … He L (Human molecular genetics 2004) 3 4 22 45 60
  4. No association was found between a functional SNP in ZDHHC8 and schizophrenia in a Japanese case-control population. (PMID: 15631889) Saito S … Ozaki N (Neuroscience letters 2005) 3 4 45 60
  5. The ZDHHC8 gene did not associate with bipolar disorder or schizophrenia. (PMID: 16150541) Otani K … Kuroda S (Neuroscience letters 2005) 3 4 45 60

Products for ZDHHC8 Gene

Sources for ZDHHC8 Gene

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