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Aliases for ZDHHC8 Gene

Aliases for ZDHHC8 Gene

  • Zinc Finger, DHHC-Type Containing 8 2 3
  • ZNF378 3 4 6
  • Zinc Finger Protein 378 3 4
  • KIAA1292 4 6
  • ZDHHCL1 3 4
  • Membrane-Associated DHHC8 Zinc Finger Protein 3
  • Zinc Finger DHHC Domain-Containing Protein 8 4
  • Zinc Finger, DHHC Domain Like Containing 1 3
  • Probable Palmitoyltransferase ZDHHC8 3
  • EC 4
  • EC 2.3.1 63
  • DHHC-8 4
  • DHHC8 3

External Ids for ZDHHC8 Gene

Previous GeneCards Identifiers for ZDHHC8 Gene

  • GC22P017059
  • GC22P018494
  • GC22P018493
  • GC22P018499
  • GC22P020116
  • GC22P003740

Summaries for ZDHHC8 Gene

Entrez Gene Summary for ZDHHC8 Gene

  • This gene encodes a four transmembrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein may function as a palmitoyltransferase. Defects in this gene may be associated with a susceptibility to schizophrenia. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 22.[provided by RefSeq, May 2010]

GeneCards Summary for ZDHHC8 Gene

ZDHHC8 (Zinc Finger, DHHC-Type Containing 8) is a Protein Coding gene. Diseases associated with ZDHHC8 include schizophrenia. GO annotations related to this gene include transferase activity, transferring acyl groups. An important paralog of this gene is ZDHHC4.

UniProtKB/Swiss-Prot for ZDHHC8 Gene

  • Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1.

Gene Wiki entry for ZDHHC8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC8 Gene

Genomics for ZDHHC8 Gene

Regulatory Elements for ZDHHC8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZDHHC8 Gene

20,129,456 bp from pter
20,148,007 bp from pter
18,552 bases
Plus strand

Genomic View for ZDHHC8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZDHHC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC8 Gene

Proteins for ZDHHC8 Gene

  • Protein details for ZDHHC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable palmitoyltransferase ZDHHC8
    Protein Accession:
    Secondary Accessions:
    • Q2TGE9
    • Q6ICL1
    • Q6ZNF5
    • Q7Z6L9

    Protein attributes for ZDHHC8 Gene

    765 amino acids
    Molecular mass:
    81443 Da
    Quaternary structure:
    No Data Available
    • According to PubMed:15489219 and PubMed:15184899, defects in ZDHHC8 may contribute to susceptibility to schizophrenia, but according to PubMed:15992527, PubMed:15631889 and PubMed:16150541, it is not the case
    • Sequence=BAD18420.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAG30243.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZDHHC8 Gene


neXtProt entry for ZDHHC8 Gene

Proteomics data for ZDHHC8 Gene at MOPED

Post-translational modifications for ZDHHC8 Gene

  • Ubiquitination at Lys224
  • Modification sites at PhosphoSitePlus

Other Protein References for ZDHHC8 Gene

Antibody Products

Domains for ZDHHC8 Gene

Gene Families for ZDHHC8 Gene

  • ZDHHC :Zinc fingers, DHHC-type

Protein Domains for ZDHHC8 Gene

Suggested Antigen Peptide Sequences for ZDHHC8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9ULC8
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
  • Contains 1 DHHC-type zinc finger.
genes like me logo Genes that share domains with ZDHHC8: view

Function for ZDHHC8 Gene

Molecular function for ZDHHC8 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA
UniProtKB/Swiss-Prot Function:
Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1.

Enzyme Numbers (IUBMB) for ZDHHC8 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016409 palmitoyltransferase activity IDA 23034182
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC8: view

Phenotypes for ZDHHC8 Gene

genes like me logo Genes that share phenotypes with ZDHHC8: view

Animal Models for ZDHHC8 Gene

MGI Knock Outs for ZDHHC8:

Animal Model Products

miRNA for ZDHHC8 Gene

miRTarBase miRNAs that target ZDHHC8

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZDHHC8

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for ZDHHC8 Gene

Localization for ZDHHC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC8 Gene

Cytoplasmic vesicle membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ZDHHC8 Gene COMPARTMENTS Subcellular localization image for ZDHHC8 gene
Compartment Confidence
mitochondrion 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ZDHHC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005794 Golgi apparatus IDA 16647879
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC8: view

Pathways for ZDHHC8 Gene

SuperPathways for ZDHHC8 Gene

No Data Available

Interacting Proteins for ZDHHC8 Gene

Gene Ontology (GO) - Biological Process for ZDHHC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development --
GO:0007626 locomotory behavior IEA --
GO:0008152 metabolic process --
GO:0018345 protein palmitoylation IDA 23034182
genes like me logo Genes that share ontologies with ZDHHC8: view

No data available for Pathways by source for ZDHHC8 Gene

Transcripts for ZDHHC8 Gene

Unigene Clusters for ZDHHC8 Gene

Zinc finger, DHHC-type containing 8:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZDHHC8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC8 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP5: - - - - - - - -
SP6: -
SP7: - -

Relevant External Links for ZDHHC8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZDHHC8 Gene

mRNA expression in normal human tissues for ZDHHC8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ZDHHC8 Gene

This gene is overexpressed in Plasma (52.4) and Heart (14.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZDHHC8 Gene

SOURCE GeneReport for Unigene cluster for ZDHHC8 Gene Hs.63128

genes like me logo Genes that share expressions with ZDHHC8: view

Expression partners for ZDHHC8 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZDHHC8 Gene

Orthologs for ZDHHC8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZDHHC8 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia ZDHHC8 35
  • 89.54 (n)
  • 93.86 (a)
  • 88 (a)
(Mus musculus)
Mammalia Zdhhc8 35
  • 85.7 (n)
  • 91.99 (a)
Zdhhc8 16
Zdhhc8 36
  • 87 (a)
(Pan troglodytes)
Mammalia ZDHHC8 35
  • 97.37 (n)
  • 97.5 (a)
  • 88 (a)
(Rattus norvegicus)
Mammalia Zdhhc8 35
  • 86.09 (n)
  • 91.99 (a)
(Bos Taurus)
Mammalia ZDHHC8 36
  • 74 (a)
(Monodelphis domestica)
Mammalia ZDHHC8 36
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia ZDHHC8 36
  • 89 (a)
(Gallus gallus)
Aves ZDHHC8 35
  • 67.19 (n)
  • 68.47 (a)
  • 62 (a)
(Anolis carolinensis)
Reptilia ZDHHC8 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc8 35
  • 63.79 (n)
  • 64.81 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32325 35
(Danio rerio)
Actinopterygii zdhhc5 35
zdhhc8b 35
  • 61.6 (n)
  • 61.69 (a)
zdhhc8b 36
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34449 36
  • 25 (a)
(Caenorhabditis elegans)
Secernentea dhhc-8 36
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
Species with no ortholog for ZDHHC8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC8 Gene

Gene Tree for ZDHHC8 (if available)
Gene Tree for ZDHHC8 (if available)

Paralogs for ZDHHC8 Gene

Selected SIMAP similar genes for ZDHHC8 Gene using alignment to 3 proteins: Pseudogenes for ZDHHC8 Gene

genes like me logo Genes that share paralogs with ZDHHC8: view

Variants for ZDHHC8 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC8 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs175170 -- 20,133,557(+) AACCC(C/T)GTCTC intron-variant
rs175171 -- 20,134,325(+) GCCCC(A/G)CCTCT intron-variant
rs175172 -- 20,134,605(+) CGGAC(G/T)TTACC intron-variant
rs175173 -- 20,135,712(+) GGCCT(G/T)GGGTA intron-variant
rs175174 -- 20,140,031(+) GGAGG(A/G)GGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC8 Gene

Variant ID Type Subtype PubMed ID
nsv435744 CNV Deletion 17901297
nsv828938 CNV Gain 20364138
nsv828939 CNV Loss 20364138
nsv914327 CNV Loss 21882294
nsv471183 CNV Loss 18288195
nsv834133 CNV Loss 17160897
dgv1387e1 CNV Complex 17122850
dgv726n67 CNV Gain 20364138
dgv4855n71 CNV Loss 21882294
dgv4856n71 CNV Loss 21882294
dgv4857n71 CNV Loss 21882294
dgv4858n71 CNV Loss 21882294
dgv4859n71 CNV Loss 21882294
dgv4860n71 CNV Loss 21882294
nsv914347 CNV Loss 21882294
dgv4861n71 CNV Loss 21882294
nsv834134 CNV Loss 17160897

Relevant External Links for ZDHHC8 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC8 Gene

Disorders for ZDHHC8 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ZDHHC8 Gene in MalaCards »

(1) Diseases for ZDHHC8 Gene including...

(1) University of Copenhagen DISEASES for ZDHHC8 Gene

Relevant External Links for ZDHHC8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ZDHHC8: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for ZDHHC8 Gene

Publications for ZDHHC8 Gene

  1. Case-control study and transmission disequilibrium test provide consistent evidence for association between schizophrenia and genetic variation in the 22q11 gene ZDHHC8. (PMID: 15489219) Chen W.-Y. … He L. (Hum. Mol. Genet. 2004) 3 4 23 48
  2. No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples. (PMID: 15992527) Glaser B. … Owen M.J. (Biol. Psychiatry 2005) 3 4 23 48
  3. Evidence that the gene encoding ZDHHC8 contributes to the risk of schizophrenia. (PMID: 15184899) Mukai J. … Gogos J.A. (Nat. Genet. 2004) 2 3 4 48
  4. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4
  5. ZDHHC8 as a candidate gene for schizophrenia: analysis of a putative functional intronic marker in case-control and family-based association studies. (PMID: 16225675) Faul T. … StAPber G. (BMC Psychiatry 2005) 3 23 48

Products for ZDHHC8 Gene

Sources for ZDHHC8 Gene

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