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Aliases for ZDHHC8 Gene

Aliases for ZDHHC8 Gene

  • Zinc Finger DHHC-Type Containing 8 2 3 5
  • Zinc Finger Protein 378 3 4
  • ZDHHCL1 3 4
  • ZNF378 3 4
  • Membrane-Associated DHHC8 Zinc Finger Protein 3
  • Zinc Finger DHHC Domain-Containing Protein 8 4
  • Zinc Finger, DHHC Domain Like Containing 1 3
  • Probable Palmitoyltransferase ZDHHC8 3
  • EC 2.3.1.225 4
  • KIAA1292 4
  • EC 2.3.1 61
  • DHHC-8 4
  • DHHC8 3

External Ids for ZDHHC8 Gene

Previous GeneCards Identifiers for ZDHHC8 Gene

  • GC22P017059
  • GC22P018494
  • GC22P018493
  • GC22P018499
  • GC22P020116
  • GC22P003740

Summaries for ZDHHC8 Gene

Entrez Gene Summary for ZDHHC8 Gene

  • This gene encodes a four transmembrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein may function as a palmitoyltransferase. Defects in this gene may be associated with a susceptibility to schizophrenia. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 22.[provided by RefSeq, May 2010]

GeneCards Summary for ZDHHC8 Gene

ZDHHC8 (Zinc Finger DHHC-Type Containing 8) is a Protein Coding gene. Diseases associated with ZDHHC8 include Schizophrenia and Velocardiofacial Syndrome. Among its related pathways are Lipoprotein metabolism and Metabolism. GO annotations related to this gene include receptor activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC5.

UniProtKB/Swiss-Prot for ZDHHC8 Gene

  • Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1.

Gene Wiki entry for ZDHHC8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC8 Gene

Genomics for ZDHHC8 Gene

Regulatory Elements for ZDHHC8 Gene

Enhancers for ZDHHC8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G020078 2 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -47.9 -47935 5.2 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC DGCR8 RPL8P5 TRMT2A ENSG00000243762 RANBP1 ENSG00000273300 SCARF2 MIR185 ZDHHC8 TBX1
GH22G020098 0.9 Ensembl ENCODE 21.9 -29.5 -29467 2.8 HDAC1 CEBPB TSC22D4 RBBP5 ATF2 SREBF1 ZNF274 POLR2A MYNN ID3 ZDHHC8 ABHD17AP4 MIR185 LOC284865 MIR1306 ENSG00000243762
GH22G020114 1.4 ENCODE dbSUPER 13.6 -12.2 -12211 4.6 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 SLC30A9 ZNF143 ZNF263 SP3 RPL7AP70 ZDHHC8 TBX1 ABHD17AP4 CCDC188 TRMT2A ARVCF RANBP1
GH22G020128 1.4 Ensembl ENCODE 12 -0.3 -326 1.4 CREB3L1 AGO1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC RPL7AP70 ZDHHC8 TBX1 ENSG00000273343 CCDC188 ENSG00000264346
GH22G020153 1.4 FANTOM5 Ensembl ENCODE 11.3 +25.3 25344 2.1 RB1 CREB3L1 AGO1 ARID4B SIN3A DMAP1 RAD21 ZNF121 GLIS2 FOS CCDC188 ZDHHC8 GC22P020198
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZDHHC8 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZDHHC8 Gene

Chromosome:
22
Start:
20,129,456 bp from pter
End:
20,148,007 bp from pter
Size:
18,552 bases
Orientation:
Plus strand

Genomic View for ZDHHC8 Gene

Genes around ZDHHC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC8 Gene

Proteins for ZDHHC8 Gene

  • Protein details for ZDHHC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULC8-ZDHC8_HUMAN
    Recommended name:
    Probable palmitoyltransferase ZDHHC8
    Protein Accession:
    Q9ULC8
    Secondary Accessions:
    • Q2TGE9
    • Q6ICL1
    • Q6ZNF5
    • Q7Z6L9

    Protein attributes for ZDHHC8 Gene

    Size:
    765 amino acids
    Molecular mass:
    81443 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • According to PubMed:15489219 and PubMed:15184899, defects in ZDHHC8 may contribute to susceptibility to schizophrenia, but according to PubMed:15992527, PubMed:15631889 and PubMed:16150541, it is not the case.
    SequenceCaution:
    • Sequence=BAD18420.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAG30243.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZDHHC8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZDHHC8 Gene

Selected DME Specific Peptides for ZDHHC8 Gene

Q9ULC8:
  • FYRPPRCSHCSVCDNCVE
  • WVNNCIG
  • FAPHALPNRNGSLSYDSLLNPGSP
  • REPSPVRYDNLSR
  • PLKVKLSDNGLKAG
  • FLFVLANFSMATFMDPG
  • DSLFGDSGVYD
  • VTGKFRGGVNPFT
  • TMAVMCVAGLFFIPV
  • RGRTTNE
  • EDEDKEDDFRAPLYK
  • EQVPGPDSLTL
  • GIQVRMKWCATC
  • PPFLRPE

Post-translational modifications for ZDHHC8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZDHHC8 Gene

Domains & Families for ZDHHC8 Gene

Gene Families for ZDHHC8 Gene

Protein Domains for ZDHHC8 Gene

Suggested Antigen Peptide Sequences for ZDHHC8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULC8

UniProtKB/Swiss-Prot:

ZDHC8_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
genes like me logo Genes that share domains with ZDHHC8: view

Function for ZDHHC8 Gene

Molecular function for ZDHHC8 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
UniProtKB/Swiss-Prot Function:
Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1.

Enzyme Numbers (IUBMB) for ZDHHC8 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016409 palmitoyltransferase activity IDA 23034182
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity TAS --
genes like me logo Genes that share ontologies with ZDHHC8: view
genes like me logo Genes that share phenotypes with ZDHHC8: view

Animal Models for ZDHHC8 Gene

MGI Knock Outs for ZDHHC8:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZDHHC8 Gene

Localization for ZDHHC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC8 Gene

Cytoplasmic vesicle membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC8 gene
Compartment Confidence
golgi apparatus 5
cytosol 4
mitochondrion 3
plasma membrane 2
extracellular 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ZDHHC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005794 Golgi apparatus IDA 16647879
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC8: view

Pathways & Interactions for ZDHHC8 Gene

genes like me logo Genes that share pathways with ZDHHC8: view

Interacting Proteins for ZDHHC8 Gene

Gene Ontology (GO) - Biological Process for ZDHHC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007626 locomotory behavior IEA --
GO:0018345 protein palmitoylation IDA 23034182
GO:0034380 high-density lipoprotein particle assembly TAS --
GO:0042157 lipoprotein metabolic process TAS --
GO:1903146 regulation of mitophagy IMP 24912190
genes like me logo Genes that share ontologies with ZDHHC8: view

No data available for SIGNOR curated interactions for ZDHHC8 Gene

Drugs & Compounds for ZDHHC8 Gene

(1) Drugs for ZDHHC8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for ZDHHC8 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
genes like me logo Genes that share compounds with ZDHHC8: view

Transcripts for ZDHHC8 Gene

Unigene Clusters for ZDHHC8 Gene

Zinc finger, DHHC-type containing 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC8 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4:
SP5: - - - - - - - -
SP6: -
SP7: - -

Relevant External Links for ZDHHC8 Gene

GeneLoc Exon Structure for
ZDHHC8
ECgene alternative splicing isoforms for
ZDHHC8

Expression for ZDHHC8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZDHHC8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZDHHC8 Gene

This gene is overexpressed in Plasma (52.4) and Heart (14.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZDHHC8 Gene



Protein tissue co-expression partners for ZDHHC8 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZDHHC8 Gene:

ZDHHC8

SOURCE GeneReport for Unigene cluster for ZDHHC8 Gene:

Hs.63128

Evidence on tissue expression from TISSUES for ZDHHC8 Gene

  • Nervous system(4.6)
  • Blood(4.2)
genes like me logo Genes that share expression patterns with ZDHHC8: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC8 Gene

Orthologs for ZDHHC8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZDHHC8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC8 34 35
  • 97.37 (n)
dog
(Canis familiaris)
Mammalia ZDHHC8 34 35
  • 89.54 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC8 35
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zdhhc8 34
  • 86.09 (n)
mouse
(Mus musculus)
Mammalia Zdhhc8 34 16 35
  • 85.7 (n)
cow
(Bos Taurus)
Mammalia ZDHHC8 35
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZDHHC8 35
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZDHHC8 34 35
  • 67.19 (n)
lizard
(Anolis carolinensis)
Reptilia ZDHHC8 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc8 34
  • 63.79 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32325 34
zebrafish
(Danio rerio)
Actinopterygii zdhhc8b 34 35
  • 61.6 (n)
zdhhc5 34
fruit fly
(Drosophila melanogaster)
Insecta CG34449 35
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dhhc-8 35
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 47 (a)
OneToMany
Species where no ortholog for ZDHHC8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC8 Gene

ENSEMBL:
Gene Tree for ZDHHC8 (if available)
TreeFam:
Gene Tree for ZDHHC8 (if available)

Paralogs for ZDHHC8 Gene

Paralogs for ZDHHC8 Gene

(6) SIMAP similar genes for ZDHHC8 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZDHHC8 Gene

genes like me logo Genes that share paralogs with ZDHHC8: view

Variants for ZDHHC8 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC8 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs193920775 Uncertain significance 20,141,427(+) GAGTG(A/C/T)CCTGT reference, missense
rs1000007222 -- 20,132,581(+) CTTGG(C/T)CTCCT intron-variant
rs1000133423 -- 20,130,948(+) ACCTA(-/TAG)GGGAG upstream-variant-2KB
rs1000375308 -- 20,146,056(+) GCGCC(A/G)TGTCT intron-variant, utr-variant-3-prime
rs1000461423 -- 20,130,665(+) TACGG(C/T)TGCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC8 Gene

Variant ID Type Subtype PubMed ID
dgv4480n100 CNV gain 25217958
dgv4481n100 CNV gain 25217958
dgv726n67 CNV gain 20364138
dgv7983n54 CNV gain 21841781
esv2758825 CNV loss 17122850
esv3647284 CNV gain 21293372
esv3893434 CNV gain 25118596
nsv1112810 CNV deletion 24896259
nsv471183 CNV loss 18288195
nsv588248 CNV loss 21841781
nsv828938 CNV gain 20364138
nsv828939 CNV loss 20364138
nsv834133 CNV loss 17160897
nsv834134 CNV loss 17160897
nsv953027 CNV deletion 24416366

Variation tolerance for ZDHHC8 Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.98; 68.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZDHHC8 Gene

Human Gene Mutation Database (HGMD)
ZDHHC8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZDHHC8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC8 Gene

Disorders for ZDHHC8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZDHHC8 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • schizophrenia 12
velocardiofacial syndrome
  • 22q11 deletion syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZDHHC8

Genetic Association Database (GAD)
ZDHHC8
Human Genome Epidemiology (HuGE) Navigator
ZDHHC8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZDHHC8
genes like me logo Genes that share disorders with ZDHHC8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZDHHC8 Gene

Publications for ZDHHC8 Gene

  1. No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples. (PMID: 15992527) Glaser B. … Owen M.J. (Biol. Psychiatry 2005) 3 4 22 46 64
  2. Evidence that the gene encoding ZDHHC8 contributes to the risk of schizophrenia. (PMID: 15184899) Mukai J. … Gogos J.A. (Nat. Genet. 2004) 2 3 4 46 64
  3. Case-control study and transmission disequilibrium test provide consistent evidence for association between schizophrenia and genetic variation in the 22q11 gene ZDHHC8. (PMID: 15489219) Chen W.-Y. … He L. (Hum. Mol. Genet. 2004) 3 4 22 46 64
  4. No association was found between a functional SNP in ZDHHC8 and schizophrenia in a Japanese case-control population. (PMID: 15631889) Saito S. … Ozaki N. (Neurosci. Lett. 2005) 3 4 46 64
  5. The ZDHHC8 gene did not associate with bipolar disorder or schizophrenia. (PMID: 16150541) Otani K. … Kuroda S. (Neurosci. Lett. 2005) 3 4 46 64

Products for ZDHHC8 Gene

Sources for ZDHHC8 Gene

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