Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZDHHC8 Gene

Aliases for ZDHHC8 Gene

  • Zinc Finger DHHC-Type Containing 8 2 3
  • Zinc Finger, DHHC-Type Containing 8 3 5
  • Zinc Finger Protein 378 3 4
  • ZDHHCL1 3 4
  • ZNF378 3 4
  • Membrane-Associated DHHC8 Zinc Finger Protein 3
  • Zinc Finger DHHC Domain-Containing Protein 8 4
  • Zinc Finger, DHHC Domain Like Containing 1 3
  • EC 2.3.1.225 4
  • KIAA1292 4
  • EC 2.3.1 63
  • DHHC-8 4
  • DHHC8 3

External Ids for ZDHHC8 Gene

Previous GeneCards Identifiers for ZDHHC8 Gene

  • GC22P017059
  • GC22P018494
  • GC22P018493
  • GC22P018499
  • GC22P020116
  • GC22P003740

Summaries for ZDHHC8 Gene

Entrez Gene Summary for ZDHHC8 Gene

  • This gene encodes a four transmembrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein may function as a palmitoyltransferase. Defects in this gene may be associated with a susceptibility to schizophrenia. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 22.[provided by RefSeq, May 2010]

GeneCards Summary for ZDHHC8 Gene

ZDHHC8 (Zinc Finger DHHC-Type Containing 8) is a Protein Coding gene. Diseases associated with ZDHHC8 include schizophrenia and velocardiofacial syndrome. Among its related pathways are Lipoprotein metabolism and Metabolism. GO annotations related to this gene include receptor activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC18.

UniProtKB/Swiss-Prot for ZDHHC8 Gene

  • Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1.

Gene Wiki entry for ZDHHC8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC8 Gene

Genomics for ZDHHC8 Gene

Regulatory Elements for ZDHHC8 Gene

Promoters for ZDHHC8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZDHHC8 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZDHHC8 Gene

Chromosome:
22
Start:
20,129,456 bp from pter
End:
20,148,007 bp from pter
Size:
18,552 bases
Orientation:
Plus strand

Genomic View for ZDHHC8 Gene

Genes around ZDHHC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC8 Gene

Proteins for ZDHHC8 Gene

  • Protein details for ZDHHC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULC8-ZDHC8_HUMAN
    Recommended name:
    Probable palmitoyltransferase ZDHHC8
    Protein Accession:
    Q9ULC8
    Secondary Accessions:
    • Q2TGE9
    • Q6ICL1
    • Q6ZNF5
    • Q7Z6L9

    Protein attributes for ZDHHC8 Gene

    Size:
    765 amino acids
    Molecular mass:
    81443 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • According to PubMed:15489219 and PubMed:15184899, defects in ZDHHC8 may contribute to susceptibility to schizophrenia, but according to PubMed:15992527, PubMed:15631889 and PubMed:16150541, it is not the case.
    SequenceCaution:
    • Sequence=BAD18420.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAG30243.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZDHHC8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZDHHC8 Gene

Proteomics data for ZDHHC8 Gene at MOPED

Post-translational modifications for ZDHHC8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZDHHC8 Gene

Antibody Products

Domains & Families for ZDHHC8 Gene

Gene Families for ZDHHC8 Gene

Protein Domains for ZDHHC8 Gene

Suggested Antigen Peptide Sequences for ZDHHC8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULC8

UniProtKB/Swiss-Prot:

ZDHC8_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
  • Contains 1 DHHC-type zinc finger.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
Similarity:
  • Contains 1 DHHC-type zinc finger.
genes like me logo Genes that share domains with ZDHHC8: view

Function for ZDHHC8 Gene

Molecular function for ZDHHC8 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
UniProtKB/Swiss-Prot Function:
Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1.

Enzyme Numbers (IUBMB) for ZDHHC8 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016409 palmitoyltransferase activity IDA 23034182
genes like me logo Genes that share ontologies with ZDHHC8: view
genes like me logo Genes that share phenotypes with ZDHHC8: view

Animal Models for ZDHHC8 Gene

MGI Knock Outs for ZDHHC8:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZDHHC8 Gene

Localization for ZDHHC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC8 Gene

Cytoplasmic vesicle membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZDHHC8 Gene COMPARTMENTS Subcellular localization image for ZDHHC8 gene
Compartment Confidence
golgi apparatus 5
mitochondrion 3
plasma membrane 2
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for ZDHHC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ZDHHC8: view

Pathways & Interactions for ZDHHC8 Gene

genes like me logo Genes that share pathways with ZDHHC8: view

Interacting Proteins for ZDHHC8 Gene

Gene Ontology (GO) - Biological Process for ZDHHC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903146 regulation of mitophagy IMP 24912190
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24912190
genes like me logo Genes that share ontologies with ZDHHC8: view

No data available for SIGNOR curated interactions for ZDHHC8 Gene

Drugs & Compounds for ZDHHC8 Gene

(1) Drugs for ZDHHC8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for ZDHHC8 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
genes like me logo Genes that share compounds with ZDHHC8: view

Transcripts for ZDHHC8 Gene

Unigene Clusters for ZDHHC8 Gene

Zinc finger, DHHC-type containing 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC8 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4:
SP5: - - - - - - - -
SP6: -
SP7: - -

Relevant External Links for ZDHHC8 Gene

GeneLoc Exon Structure for
ZDHHC8
ECgene alternative splicing isoforms for
ZDHHC8

Expression for ZDHHC8 Gene

mRNA expression in normal human tissues for ZDHHC8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZDHHC8 Gene

This gene is overexpressed in Plasma (52.4) and Heart (14.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZDHHC8 Gene



SOURCE GeneReport for Unigene cluster for ZDHHC8 Gene Hs.63128

genes like me logo Genes that share expression patterns with ZDHHC8: view

Protein tissue co-expression partners for ZDHHC8 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZDHHC8 Gene

Orthologs for ZDHHC8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZDHHC8 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ZDHHC8 35
  • 89.54 (n)
  • 93.86 (a)
ZDHHC8 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zdhhc8 35
  • 85.7 (n)
  • 91.99 (a)
Zdhhc8 16
Zdhhc8 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC8 35
  • 97.37 (n)
  • 97.5 (a)
ZDHHC8 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zdhhc8 35
  • 86.09 (n)
  • 91.99 (a)
cow
(Bos Taurus)
Mammalia ZDHHC8 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZDHHC8 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC8 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZDHHC8 35
  • 67.19 (n)
  • 68.47 (a)
ZDHHC8 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZDHHC8 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc8 35
  • 63.79 (n)
  • 64.81 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32325 35
zebrafish
(Danio rerio)
Actinopterygii zdhhc5 35
zdhhc8b 35
  • 61.6 (n)
  • 61.69 (a)
zdhhc8b 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG34449 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dhhc-8 36
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
Species with no ortholog for ZDHHC8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC8 Gene

ENSEMBL:
Gene Tree for ZDHHC8 (if available)
TreeFam:
Gene Tree for ZDHHC8 (if available)

Paralogs for ZDHHC8 Gene

Paralogs for ZDHHC8 Gene

(6) SIMAP similar genes for ZDHHC8 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZDHHC8 Gene

genes like me logo Genes that share paralogs with ZDHHC8: view

Variants for ZDHHC8 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC8 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs695322 -- 20,139,830(+) TGGCC(-/C)TTCGG reference, frameshift-variant
rs701451 -- 20,146,534(+) CCCCA(A/G)AAGAG intron-variant, utr-variant-3-prime
rs701452 -- 20,143,754(+) GTGCA(A/G)AGGTG reference, synonymous-codon
rs175170 -- 20,133,557(+) AACCC(C/T)GTCTC intron-variant
rs175171 -- 20,134,325(+) GCCCC(A/G)CCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC8 Gene

Variant ID Type Subtype PubMed ID
nsv435744 CNV Deletion 17901297
nsv828938 CNV Gain 20364138
nsv828939 CNV Loss 20364138
nsv914327 CNV Loss 21882294
nsv471183 CNV Loss 18288195
nsv834133 CNV Loss 17160897
dgv1387e1 CNV Complex 17122850
dgv726n67 CNV Gain 20364138
dgv4855n71 CNV Loss 21882294
dgv4856n71 CNV Loss 21882294
dgv4857n71 CNV Loss 21882294
dgv4858n71 CNV Loss 21882294
dgv4859n71 CNV Loss 21882294
dgv4860n71 CNV Loss 21882294
nsv914347 CNV Loss 21882294
dgv4861n71 CNV Loss 21882294
nsv834134 CNV Loss 17160897

Variation tolerance for ZDHHC8 Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.98; 68.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZDHHC8 Gene

HapMap Linkage Disequilibrium report
ZDHHC8
Human Gene Mutation Database (HGMD)
ZDHHC8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC8 Gene

Disorders for ZDHHC8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZDHHC8 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • schizophrenia 12
velocardiofacial syndrome
  • cayler cardiofacial syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZDHHC8

Genetic Association Database (GAD)
ZDHHC8
Human Genome Epidemiology (HuGE) Navigator
ZDHHC8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZDHHC8
genes like me logo Genes that share disorders with ZDHHC8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZDHHC8 Gene

Publications for ZDHHC8 Gene

  1. Evidence that the gene encoding ZDHHC8 contributes to the risk of schizophrenia. (PMID: 15184899) Mukai J. … Gogos J.A. (Nat. Genet. 2004) 2 3 4 48 67
  2. HTF9C gene of 22q11.21 region associates with schizophrenia having deficit-sustained attention. (PMID: 18075473) Liu Y.L. … Hwu H.G. (Psychiatr. Genet. 2007) 3 23
  3. No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples. (PMID: 15992527) Glaser B. … Owen M.J. (Biol. Psychiatry 2005) 3 23
  4. ZDHHC8 as a candidate gene for schizophrenia: analysis of a putative functional intronic marker in case-control and family-based association studies. (PMID: 16225675) Faul T. … StAPber G. (BMC Psychiatry 2005) 3 23
  5. Case-control study and transmission disequilibrium test provide consistent evidence for association between schizophrenia and genetic variation in the 22q11 gene ZDHHC8. (PMID: 15489219) Chen W.-Y. … He L. (Hum. Mol. Genet. 2004) 3 23

Products for ZDHHC8 Gene

Sources for ZDHHC8 Gene

Back to Top

Content