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Aliases for ZDHHC7 Gene

Aliases for ZDHHC7 Gene

  • Zinc Finger DHHC-Type Containing 7 2 3 5
  • Zinc Finger DHHC Domain-Containing Protein 7 3 4
  • DHHC-7 3 4
  • Sertoli Cell Gene With Zinc Finger Domain-β 2
  • Zinc Finger, DHHC Domain Containing 7 3
  • Palmitoyltransferase ZDHHC7 3
  • Zinc Finger Protein 370 3
  • EC 2.3.1.225 4
  • EC 2.3.1 58
  • SERZ-B 3
  • ZNF370 3
  • DHHC7 3
  • SERZ1 3

External Ids for ZDHHC7 Gene

Previous GeneCards Identifiers for ZDHHC7 Gene

  • GC16M075554
  • GC16M085974
  • GC16M084746
  • GC16M084787
  • GC16M083565
  • GC16M070760

Summaries for ZDHHC7 Gene

GeneCards Summary for ZDHHC7 Gene

ZDHHC7 (Zinc Finger DHHC-Type Containing 7) is a Protein Coding gene. GO annotations related to this gene include protein-cysteine S-palmitoyltransferase activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC3.

UniProtKB/Swiss-Prot for ZDHHC7 Gene

  • Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95 (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones (PubMed:22031296). May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (By similarity).

Additional gene information for ZDHHC7 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC7 Gene

Genomics for ZDHHC7 Gene

Regulatory Elements for ZDHHC7 Gene


Enhancers around ZDHHC7 on UCSC Golden Path with GeneCards custom track

Promoters for ZDHHC7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000088907 432 1801 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143

Genomic Location for ZDHHC7 Gene

Chromosome:
16
Start:
84,974,181 bp from pter
End:
85,011,732 bp from pter
Size:
37,552 bases
Orientation:
Minus strand

Genomic View for ZDHHC7 Gene

Genes around ZDHHC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC7 Gene

Proteins for ZDHHC7 Gene

  • Protein details for ZDHHC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXF8-ZDHC7_HUMAN
    Recommended name:
    Palmitoyltransferase ZDHHC7
    Protein Accession:
    Q9NXF8
    Secondary Accessions:
    • D3DUM1
    • Q8WV42
    • Q9NVD8

    Protein attributes for ZDHHC7 Gene

    Size:
    308 amino acids
    Molecular mass:
    35140 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH17702.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91814.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZDHHC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZDHHC7 Gene

Selected DME Specific Peptides for ZDHHC7 Gene

Q9NXF8:
  • MDHHCPW
  • WFIRDGCG
  • MLTDPGAVPKGNATKE
  • FVLFTMYIAL

Post-translational modifications for ZDHHC7 Gene

Domains & Families for ZDHHC7 Gene

Gene Families for ZDHHC7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for ZDHHC7 Gene

Suggested Antigen Peptide Sequences for ZDHHC7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NXF8

UniProtKB/Swiss-Prot:

ZDHC7_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family.
genes like me logo Genes that share domains with ZDHHC7: view

Function for ZDHHC7 Gene

Molecular function for ZDHHC7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
UniProtKB/Swiss-Prot Function:
Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95 (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones (PubMed:22031296). May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (By similarity).

Enzyme Numbers (IUBMB) for ZDHHC7 Gene

Phenotypes From GWAS Catalog for ZDHHC7 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016409 palmitoyltransferase activity IDA,IEA 23034182
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC7: view

Phenotypes for ZDHHC7 Gene

GenomeRNAi human phenotypes for ZDHHC7:
genes like me logo Genes that share phenotypes with ZDHHC7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZDHHC7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC7 Gene

Localization for ZDHHC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC7 Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC7 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 4
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZDHHC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IDA 16647879
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC7: view

Pathways & Interactions for ZDHHC7 Gene

SuperPathways for ZDHHC7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018230 peptidyl-L-cysteine S-palmitoylation IMP 22031296
GO:0018345 protein palmitoylation IEA,IDA 23034182
genes like me logo Genes that share ontologies with ZDHHC7: view

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC7 Gene

Drugs & Compounds for ZDHHC7 Gene

(1) Drugs for ZDHHC7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for ZDHHC7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
genes like me logo Genes that share compounds with ZDHHC7: view

Transcripts for ZDHHC7 Gene

Unigene Clusters for ZDHHC7 Gene

Zinc finger, DHHC-type containing 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZDHHC7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: - - - - -
SP5: -
SP6:
SP7:

Relevant External Links for ZDHHC7 Gene

GeneLoc Exon Structure for
ZDHHC7
ECgene alternative splicing isoforms for
ZDHHC7

Expression for ZDHHC7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZDHHC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZDHHC7 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZDHHC7 Gene



Protein tissue co-expression partners for ZDHHC7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZDHHC7 Gene:

ZDHHC7

SOURCE GeneReport for Unigene cluster for ZDHHC7 Gene:

Hs.461610

Evidence on tissue expression from TISSUES for ZDHHC7 Gene

  • Intestine(4.3)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with ZDHHC7: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC7 Gene

Orthologs for ZDHHC7 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZDHHC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC7 33 34
  • 99.57 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC7 34
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZDHHC7 34
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZDHHC7 33 34
  • 89.83 (n)
rat
(Rattus norvegicus)
Mammalia Zdhhc7 33
  • 86.8 (n)
mouse
(Mus musculus)
Mammalia Zdhhc7 33 16 34
  • 85.93 (n)
cow
(Bos Taurus)
Mammalia ZDHHC7 33 34
  • 85.5 (n)
chicken
(Gallus gallus)
Aves ZDHHC7 33 34
  • 81.75 (n)
lizard
(Anolis carolinensis)
Reptilia ZDHHC7 34
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485887 33
  • 77.19 (n)
zebrafish
(Danio rerio)
Actinopterygii zdhhc7 33 34
  • 74.5 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8314 35 34
  • 56 (a)
worm
(Caenorhabditis elegans)
Secernentea F33D11.12 35
  • 55 (a)
dhhc-3 34
  • 54 (a)
OneToMany
C17D12.1a 35
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 54 (a)
OneToMany
Species where no ortholog for ZDHHC7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC7 Gene

ENSEMBL:
Gene Tree for ZDHHC7 (if available)
TreeFam:
Gene Tree for ZDHHC7 (if available)

Paralogs for ZDHHC7 Gene

Paralogs for ZDHHC7 Gene

(5) SIMAP similar genes for ZDHHC7 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZDHHC7 Gene

genes like me logo Genes that share paralogs with ZDHHC7: view

Variants for ZDHHC7 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_036261 A colorectal cancer sample
rs1000044375 -- 85,011,854(+) CAGTG(A/G)CCTGT upstream-variant-2KB
rs1000132206 -- 84,998,927(+) TTTTT(A/G)TATTT intron-variant
rs1000239549 -- 84,995,085(+) CTGCA(A/C)TGAAT intron-variant
rs1000418835 -- 85,000,171(+) TTTCA(C/T)TGTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC7 Gene

Variant ID Type Subtype PubMed ID
esv2660467 CNV deletion 23128226
esv29431 CNV loss 19812545
esv3639449 CNV loss 21293372
nsv1066260 CNV gain 25217958
nsv1111144 CNV tandem duplication 24896259
nsv1132874 CNV insertion 24896259
nsv1134573 CNV deletion 24896259
nsv483044 CNV gain 15286789

Variation tolerance for ZDHHC7 Gene

Residual Variation Intolerance Score: 40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.14; 51.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZDHHC7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZDHHC7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC7 Gene

Disorders for ZDHHC7 Gene

Relevant External Links for ZDHHC7

Genetic Association Database (GAD)
ZDHHC7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZDHHC7

No disorders were found for ZDHHC7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC7 Gene

Publications for ZDHHC7 Gene

  1. ZDHHC7-mediated S-palmitoylation of Scribble regulates cell polarity. (PMID: 27380321) Chen B … Wu X (Nature chemical biology 2016) 2 3 60
  2. DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors. (PMID: 22031296) Pedram A … Levin ER (Molecular biology of the cell 2012) 3 4 60
  3. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson DF … Stefansson K (Nature genetics 2008) 3 45 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for ZDHHC7 Gene

Sources for ZDHHC7 Gene

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