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Aliases for ZDHHC7 Gene

Aliases for ZDHHC7 Gene

  • Zinc Finger, DHHC-Type Containing 7 2 3
  • Zinc Finger DHHC Domain-Containing Protein 7 3 4
  • Zinc Finger Protein 370 3 4
  • DHHC-7 3 4
  • ZNF370 3 4
  • DHHC7 3 6
  • Sertoli Cell Gene With Zinc Finger Domain-β 2
  • Sertoli Cell Gene With Zinc Finger Domain-&#946 3
  • Zinc Finger, DHHC Domain Containing 7 3
  • Palmitoyltransferase ZDHHC7 3
  • EC 2.3.1.225 4
  • EC 2.3.1 63
  • SERZ-B 3
  • SERZ1 3

External Ids for ZDHHC7 Gene

Summaries for ZDHHC7 Gene

GeneCards Summary for ZDHHC7 Gene

ZDHHC7 (Zinc Finger, DHHC-Type Containing 7) is a Protein Coding gene. GO annotations related to this gene include palmitoyltransferase activity. An important paralog of this gene is ZDHHC3.

UniProtKB/Swiss-Prot for ZDHHC7 Gene

  • Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95. May palmitoylate GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3) and thereby regulate their synaptic clustering and/or cell surface stability (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptors.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC7 Gene

Genomics for ZDHHC7 Gene

Genomic Location for ZDHHC7 Gene

Start:
84,974,181 bp from pter
End:
85,011,535 bp from pter
Size:
37,355 bases
Orientation:
Minus strand

Genomic View for ZDHHC7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZDHHC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC7 Gene

Regulatory Elements for ZDHHC7 Gene

Proteins for ZDHHC7 Gene

  • Protein details for ZDHHC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXF8-ZDHC7_HUMAN
    Recommended name:
    Palmitoyltransferase ZDHHC7
    Protein Accession:
    Q9NXF8
    Secondary Accessions:
    • D3DUM1
    • Q8WV42
    • Q9NVD8

    Protein attributes for ZDHHC7 Gene

    Size:
    308 amino acids
    Molecular mass:
    35140 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH17702.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91814.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZDHHC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZDHHC7 Gene

Proteomics data for ZDHHC7 Gene at MOPED

Selected DME Specific Peptides for ZDHHC7 Gene

Post-translational modifications for ZDHHC7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZDHHC7 Gene

Domains for ZDHHC7 Gene

Gene Families for ZDHHC7 Gene

HGNC:
  • ZDHHC :Zinc fingers, DHHC-type

Protein Domains for ZDHHC7 Gene

Suggested Antigen Peptide Sequences for ZDHHC7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NXF8

UniProtKB/Swiss-Prot:

ZDHC7_HUMAN
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.:
    • Q9NXF8
Family:
  • Belongs to the DHHC palmitoyltransferase family.:
    • Q9NXF8
Similarity:
  • Contains 1 DHHC-type zinc finger.:
    • Q9NXF8
genes like me logo Genes that share domains with ZDHHC7: view

Function for ZDHHC7 Gene

Molecular function for ZDHHC7 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA
UniProtKB/Swiss-Prot Function: Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95. May palmitoylate GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3) and thereby regulate their synaptic clustering and/or cell surface stability (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptors.

Enzyme Numbers (IUBMB) for ZDHHC7 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016409 palmitoyltransferase activity IDA 23034182
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC7: view

miRNA for ZDHHC7 Gene

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZDHHC7 Gene

Localization for ZDHHC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC7 Gene

Membrane; Multi-pass membrane protein. Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZDHHC7 Gene COMPARTMENTS Subcellular localization image for ZDHHC7 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for ZDHHC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005794 Golgi apparatus IDA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC7: view

Pathways for ZDHHC7 Gene

SuperPathways for ZDHHC7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018230 peptidyl-L-cysteine S-palmitoylation IMP 22031296
GO:0018345 protein palmitoylation IDA 23034182
genes like me logo Genes that share ontologies with ZDHHC7: view

No data available for Pathways by source for ZDHHC7 Gene

Transcripts for ZDHHC7 Gene

Unigene Clusters for ZDHHC7 Gene

Zinc finger, DHHC-type containing 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: - - - - -
SP5: -
SP6:
SP7:

Relevant External Links for ZDHHC7 Gene

GeneLoc Exon Structure for
ZDHHC7
ECgene alternative splicing isoforms for
ZDHHC7

Expression for ZDHHC7 Gene

mRNA expression in normal human tissues for ZDHHC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZDHHC7 Gene

SOURCE GeneReport for Unigene cluster for ZDHHC7 Gene Hs.461610

genes like me logo Genes that share expressions with ZDHHC7: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZDHHC7 Gene

Orthologs for ZDHHC7 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZDHHC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC7 35
  • 99.57 (n)
  • 100 (a)
ZDHHC7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZDHHC7 35
  • 85.5 (n)
  • 93.83 (a)
ZDHHC7 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZDHHC7 35
  • 89.83 (n)
  • 95.13 (a)
ZDHHC7 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zdhhc7 35
  • 85.93 (n)
  • 95.13 (a)
Zdhhc7 16
Zdhhc7 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZDHHC7 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC7 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zdhhc7 35
  • 86.8 (n)
  • 95.45 (a)
chicken
(Gallus gallus)
Aves ZDHHC7 35
  • 81.75 (n)
  • 90.16 (a)
ZDHHC7 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZDHHC7 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485887 35
  • 77.19 (n)
  • 85.53 (a)
zebrafish
(Danio rerio)
Actinopterygii zdhhc7 35
  • 74.5 (n)
  • 80.2 (a)
zdhhc7 36
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8314 36
  • 50 (a)
OneToMany
CG8314 37
  • 56 (a)
worm
(Caenorhabditis elegans)
Secernentea dhhc-3 36
  • 54 (a)
OneToMany
F33D11.12 37
  • 55 (a)
C17D12.1a 37
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
OneToMany
Species with no ortholog for ZDHHC7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC7 Gene

ENSEMBL:
Gene Tree for ZDHHC7 (if available)
TreeFam:
Gene Tree for ZDHHC7 (if available)

Paralogs for ZDHHC7 Gene

Paralogs for ZDHHC7 Gene

Selected SIMAP similar genes for ZDHHC7 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZDHHC7 Gene

genes like me logo Genes that share paralogs with ZDHHC7: view

Variants for ZDHHC7 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs931713 -- 84,990,249(-) TCCTC(A/G)GGTGT intron-variant
rs1044279 -- 84,975,449(-) TTTTT(G/T)TTCCA utr-variant-3-prime
rs1566458 -- 84,985,325(-) GAAGC(A/G)TGCTC intron-variant
rs1566459 -- 84,985,248(-) CTTTG(G/T)CTCAT intron-variant
rs1566460 -- 84,983,369(-) CAGAG(A/G)TTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC7 Gene

Variant ID Type Subtype PubMed ID
nsv907087 CNV Loss 21882294
nsv907088 CNV Gain 21882294
esv29431 CNV Loss 19812545
esv2660467 CNV Deletion 23128226

Relevant External Links for ZDHHC7 Gene

HapMap Linkage Disequilibrium report
ZDHHC7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC7 Gene

Disorders for ZDHHC7 Gene

Relevant External Links for ZDHHC7

Genetic Association Database (GAD)
ZDHHC7
genes like me logo Genes that share disorders with ZDHHC7: view

No data available for UniProtKB/Swiss-Prot for ZDHHC7 Gene

Publications for ZDHHC7 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 48
  4. DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors. (PMID: 22031296) Pedram A. … Levin E.R. (Mol. Biol. Cell 2012) 3 4
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for ZDHHC7 Gene

  • antibodies-online proteins for ZDHHC7
  • antibodies-online antibodies for ZDHHC7
  • antibodies-online kits for ZDHHC7

Sources for ZDHHC7 Gene

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