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Aliases for ZDHHC6 Gene

Aliases for ZDHHC6 Gene

  • Zinc Finger, DHHC-Type Containing 6 2 3
  • Zinc Finger DHHC Domain-Containing Protein 6 3 4
  • Transmembrane Protein H4 3 4
  • Zinc Finger Protein 376 3 4
  • DHHC-6 3 4
  • ZNF376 3 4
  • Palmitoyltransferase ZDHHC6 3
  • EC 4
  • EC 2.3.1 63

External Ids for ZDHHC6 Gene

Previous GeneCards Identifiers for ZDHHC6 Gene

  • GC10M113083
  • GC10M113423
  • GC10M114321
  • GC10M113854
  • GC10M114180
  • GC10M107817

Summaries for ZDHHC6 Gene

GeneCards Summary for ZDHHC6 Gene

ZDHHC6 (Zinc Finger, DHHC-Type Containing 6) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring acyl groups. An important paralog of this gene is ZDHHC7.

UniProtKB/Swiss-Prot for ZDHHC6 Gene

  • Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC6 Gene

Genomics for ZDHHC6 Gene

Regulatory Elements for ZDHHC6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZDHHC6 Gene

112,430,300 bp from pter
112,447,147 bp from pter
16,848 bases
Minus strand

Genomic View for ZDHHC6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZDHHC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC6 Gene

Proteins for ZDHHC6 Gene

  • Protein details for ZDHHC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Palmitoyltransferase ZDHHC6
    Protein Accession:
    Secondary Accessions:
    • D3DRB6
    • Q53G45
    • Q96IV7
    • Q9H605

    Protein attributes for ZDHHC6 Gene

    413 amino acids
    Molecular mass:
    47663 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB15462.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZDHHC6 Gene


neXtProt entry for ZDHHC6 Gene

Proteomics data for ZDHHC6 Gene at MOPED

Post-translational modifications for ZDHHC6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZDHHC6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for ZDHHC6 Gene

Gene Families for ZDHHC6 Gene

  • ZDHHC :Zinc fingers, DHHC-type

Protein Domains for ZDHHC6 Gene

Suggested Antigen Peptide Sequences for ZDHHC6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9H6R6
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
  • Contains 1 DHHC-type zinc finger.
genes like me logo Genes that share domains with ZDHHC6: view

Function for ZDHHC6 Gene

Molecular function for ZDHHC6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
UniProtKB/Swiss-Prot Function:
Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins.

Enzyme Numbers (IUBMB) for ZDHHC6 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016409 palmitoyltransferase activity IDA 23034182
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC6: view

Phenotypes for ZDHHC6 Gene

GenomeRNAi human phenotypes for ZDHHC6:
genes like me logo Genes that share phenotypes with ZDHHC6: view

Animal Model Products

miRNA for ZDHHC6 Gene

miRTarBase miRNAs that target ZDHHC6

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ZDHHC6 Gene

Localization for ZDHHC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC6 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ZDHHC6 Gene COMPARTMENTS Subcellular localization image for ZDHHC6 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ZDHHC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 16647879
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC6: view

Pathways for ZDHHC6 Gene

SuperPathways for ZDHHC6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018345 protein palmitoylation IDA 23034182
genes like me logo Genes that share ontologies with ZDHHC6: view

No data available for Pathways by source for ZDHHC6 Gene

Transcripts for ZDHHC6 Gene

Unigene Clusters for ZDHHC6 Gene

Zinc finger, DHHC-type containing 6:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZDHHC6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
SP1: - - - - - -
SP2: - - - - - - -
SP4: - - -
SP6: -
SP8: - -

Relevant External Links for ZDHHC6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZDHHC6 Gene

mRNA expression in normal human tissues for ZDHHC6 Gene

Protein differential expression in normal tissues for ZDHHC6 Gene

This gene is overexpressed in NK cells (20.0), CD8 Tcells (14.1), Retina (11.2), and Placenta (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZDHHC6 Gene

SOURCE GeneReport for Unigene cluster for ZDHHC6 Gene Hs.196990

genes like me logo Genes that share expressions with ZDHHC6: view

Expression partners for ZDHHC6 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZDHHC6 Gene

Orthologs for ZDHHC6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZDHHC6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZDHHC6 35
  • 92.49 (n)
  • 95.88 (a)
  • 96 (a)
(Canis familiaris)
Mammalia ZDHHC6 35
  • 93.14 (n)
  • 95.88 (a)
  • 96 (a)
(Mus musculus)
Mammalia Zdhhc6 35
  • 89.02 (n)
  • 92.74 (a)
Zdhhc6 16
Zdhhc6 36
  • 93 (a)
(Pan troglodytes)
Mammalia ZDHHC6 35
  • 99.6 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Zdhhc6 35
  • 88.46 (n)
  • 92.49 (a)
(Monodelphis domestica)
Mammalia ZDHHC6 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia ZDHHC6 36
  • 88 (a)
(Gallus gallus)
Aves ZDHHC6 35
  • 78.71 (n)
  • 82.69 (a)
  • 83 (a)
(Anolis carolinensis)
Reptilia ZDHHC6 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc6 35
  • 70.93 (n)
  • 77.4 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC52647 35
(Danio rerio)
Actinopterygii wufa04d12 35
zdhhc6 35
  • 68.61 (n)
  • 73.54 (a)
zdhhc6 36
  • 74 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000886 35
  • 51.48 (n)
  • 44.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5196 35
  • 49.17 (n)
  • 42.54 (a)
CG4483 36
  • 36 (a)
CG5196 36
  • 37 (a)
(Caenorhabditis elegans)
Secernentea M18.8 35
  • 50.84 (n)
  • 39.84 (a)
dhhc-6 36
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PFA3 36
  • 21 (a)
PFA4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G09320 35
  • 48.73 (n)
  • 37.14 (a)
(Oryza sativa)
Liliopsida Os05g0458000 35
  • 46.17 (n)
  • 37.43 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1887 35
Species with no ortholog for ZDHHC6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC6 Gene

Gene Tree for ZDHHC6 (if available)
Gene Tree for ZDHHC6 (if available)

Paralogs for ZDHHC6 Gene

Paralogs for ZDHHC6 Gene Pseudogenes for ZDHHC6 Gene

genes like me logo Genes that share paralogs with ZDHHC6: view

Variants for ZDHHC6 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC6 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs2290963 -- 112,430,533(+) AAAAT(C/T)CTACA utr-variant-3-prime
rs2290964 -- 112,430,534(+) AAATC(C/T)TACAG utr-variant-3-prime
rs2290965 -- 112,430,594(+) GAAGA(C/G)GTGGT utr-variant-3-prime
rs2306158 -- 112,432,527(+) CTGTC(A/G)TCAGT intron-variant
rs2306159 -- 112,440,597(+) AACAA(A/G)GTGGT reference, synonymous-codon, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC6 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
nsv831990 CNV Loss 17160897
nsv831991 CNV Loss 17160897
esv2741029 CNV Deletion 23290073
esv2741040 CNV Deletion 23290073

Relevant External Links for ZDHHC6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC6 Gene

Disorders for ZDHHC6 Gene

Relevant External Links for ZDHHC6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for ZDHHC6 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ZDHHC6 Gene

Publications for ZDHHC6 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  5. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. (PMID: 16647879) Ohno Y. … Igarashi Y. (Biochim. Biophys. Acta 2006) 3

Products for ZDHHC6 Gene

Sources for ZDHHC6 Gene

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