ZDHHC6 Gene
protein-coding GIFtS: 47
GCID: GC10M114180
|
|
zinc finger, DHHC-type containing 6
| |
Aliases
for ZDHHC6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger, DHHC-Type Containing 61 2 | | FLJ219521 | | ZNF3761 2 3 | | Palmitoyltransferase ZDHHC62 | | Transmembrane Protein H42 3 | | Probable Palmitoyltransferase ZDHHC62 | | Zinc Finger DHHC Domain-Containing Protein 62 3 | | Zinc Finger, DHHC Domain Containing 62 | | Zinc Finger Protein 3762 3 | | EC 2.3.1.-3 | | DHHC-62 3 | | EC 2.3.18 |
Export aliases for ZDHHC6 gene to outside databasesPrevious GC identifers: GC10M113083 GC10M113423 GC10M114321 GC10M113854 GC10M107817 |
Summaries
for ZDHHC6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZDHC6_HUMAN, Q9H6R6Function: Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex andefficient folding of glycosylated proteins
|
Genomic Views
for ZDHHC6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZDHHC6 gene promoter:
AML1a FOXJ2 (long isoform) FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZDHHC6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZDHHC6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q25.2 Ensembl cytogenetic band: 10q25.2 HGNC cytogenetic band: 10q26.11ZDHHC6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M114180: view genomic region
(about GC identifiers)
Start:
|
114,190,058 bp from pter |
End:
|
114,206,672 bp from pter |
Size:
|
16,615 bases |
Orientation:
|
minus strand |
|
Proteins
for ZDHHC6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZDHC6_HUMAN, Q9H6R6 (See
protein sequence)Recommended Name: Palmitoyltransferase ZDHHC6 Size: 413 amino acids; 47663 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Sequence caution: Sequence=BAB15462.1; Type=Erroneous initiation;
Secondary accessions: D3DRB6 Q53G45 Q96IV7 Q9H605Alternative splicing: 2 isoforms: Q9H6R6-1 Q9H6R6-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZDHHC6: NX_Q9H6R6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H6R6
4/5 DME Specific Peptides for ZDHHC6 (Q9H6R6) (see all 5)
ZDHHC6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_071939.1
ENSEMBL proteins: ENSP00000358413 ENSP00000358412
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005789 | endoplasmic reticulum membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
ZDHHC6 for ontologies About GeneDecksing
ZDHHC6 Antibody Products:
Assay Products for ZDHHC6: |
Protein
Domains /
Families
for ZDHHC6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZDHHC6 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H6R6ProtoNet protein and cluster: Q9H6R6 2 Blocks protein families: IPB001594 Zn-finger IPB011511 Variant SH3
UniProtKB/Swiss-Prot: ZDHC6_HUMAN, Q9H6R6Domain: The DHHC domain is required for palmitoyltransferase activity (By similarity)Similarity: Belongs to the DHHC palmitoyltransferase familySimilarity: Contains 1 DHHC-type zinc finger |
Function
for ZDHHC6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZDHC6_HUMAN, Q9H6R6Function: Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex andefficient folding of glycosylated proteinsCatalytic activity: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoAEnzyme Numbers (IUBMB): EC 2.3.12 EC 2.3.1.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for ZDHHC6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZDHHC6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC6 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- | | GO:0016746 | transferase activity, transferring acyl groups |
IEA | -- |
ZDHHC6 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZDHHC6:
|
Pathways & Interactions
for ZDHHC6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZDHHC6
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/10 Interacting proteins for ZDHHC6 (Q9H6R62, 3 ENSP000003584134) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
|
Drugs & Compounds
for ZDHHC6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZDHHC6
Search CenterWatch for drugs/clinical trials and news about ZDHHC6 / ZDHC6
|
Transcripts
for ZDHHC6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZDHHC6 gene: NM_022494.1 Unigene Cluster for ZDHHC6: Zinc finger, DHHC-type containing 6 Hs.196990 [show with all ESTs]Unigene Representative Sequence: BX6472704 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369405(uc001kzv.3 uc001kzw.3 uc009xya.1) ENST00000369404
ENST00000482410 ENST00000471035
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZDHHC6 (NM_022494) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZDHHC6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZDHHC6 |
Additional cDNA sequence: AF267740.1 AK025605.1 AK026369.1 AK054991.1 AK223086.1 AK308026.1 BC007213.1 BC017434.2 BX647270.1 15 DOTS entries: DT.316091 DT.121217269 DT.99941334 DT.121217350 DT.316095 DT.97844614 DT.121217088 DT.99929190 DT.121217250 DT.102842209 DT.95253090 DT.97766987 DT.100780921 DT.121217120 DT.121217358 24/193 AceView cDNA sequences (see all 193): AI245376 BF969232 H52302 AA788798 AW591218 AA806202 CA397275 AI804388 CB131762 CD722121 AI221583 AI424445 AI921374 AI278323 AI682622 AA897114 BP378060 F03815 BE041418 BC017434 AI003234 AI924949 F06016 BF115013
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC6 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | - | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | - | | | | | | | | - | | | | | | - | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZDHHC6
|
Expression
for ZDHHC6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZDHHC6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGTACTTCT
About this image
See ZDHHC6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZDHHC6
SOURCE GeneReport for Unigene cluster: Hs.196990
SABiosciences Custom PCR Arrays for ZDHHC6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZDHHC6
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC6 |
Orthologs
for ZDHHC6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ZDHHC6 gene from 9/26 species (see all 26) About this table
ENSEMBL Gene Tree for ZDHHC6 (if available)
TreeFam Gene Tree for ZDHHC6 (if available) |
Paralogs
for ZDHHC6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZDHHC6 gene
- ZDHHC162
ZDHHC6 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZDHHC6
PGOHUM00000240686
|
Genomic Variants
for ZDHHC6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZDHHC6 (114190058 - 114206672 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZDHHC6: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZDHHC6 |
|
Disorders
/ Diseases
for ZDHHC6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZDHHC6 for disorders About MalaCards
ZDHHC6 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: ZDHHC6 (1 document)
Export disorders for ZDHHC6 gene to outside databases
|
Publications
for ZDHHC6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZDHHC6 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with ZDHHC6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Comprehensive analysis of interactions between the Src -associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome. (PubMed id 22745667)1 Asbach B....Wagner R. (2012)
- Palmitoylated calnexin is a key component of the ribosome-translocon complex. (PubMed id 22314232)2 Lakkaraju A.K.... van der Goot F.G. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Proteome scale characterization of human S-acylated p roteins in lipid raft-enriched and non-raft membranes. (PubMed id 19801377)1 Yang W....Freeman M.R. (2010)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for ZDHHC6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZDHHC6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZDHHC6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZDHHC6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZDHHC6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZDHHC6 gene:
Search GeneIP for patents involving ZDHHC6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZDHHC6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |  |  |  |  | | | | |
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 | | | ZDHHC6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC6 |
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