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Aliases for ZDHHC6 Gene

Aliases for ZDHHC6 Gene

  • Zinc Finger, DHHC-Type Containing 6 2 3
  • Zinc Finger DHHC Domain-Containing Protein 6 3 4
  • Transmembrane Protein H4 3 4
  • Zinc Finger Protein 376 3 4
  • DHHC-6 3 4
  • ZNF376 3 4
  • Palmitoyltransferase ZDHHC6 3
  • EC 2.3.1.225 4
  • EC 2.3.1 64

External Ids for ZDHHC6 Gene

Summaries for ZDHHC6 Gene

GeneCards Summary for ZDHHC6 Gene

ZDHHC6 (Zinc Finger, DHHC-Type Containing 6) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring acyl groups. An important paralog of this gene is ZDHHC7.

UniProtKB/Swiss-Prot for ZDHHC6 Gene

  • Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC6 Gene

Genomics for ZDHHC6 Gene

Genomic Location for ZDHHC6 Gene

Start:
112,430,300 bp from pter
End:
112,447,147 bp from pter
Size:
16,848 bases
Orientation:
Minus strand

Genomic View for ZDHHC6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZDHHC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC6 Gene

Regulatory Elements for ZDHHC6 Gene

Proteins for ZDHHC6 Gene

  • Protein details for ZDHHC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6R6-ZDHC6_HUMAN
    Recommended name:
    Palmitoyltransferase ZDHHC6
    Protein Accession:
    Q9H6R6
    Secondary Accessions:
    • D3DRB6
    • Q53G45
    • Q96IV7
    • Q9H605

    Protein attributes for ZDHHC6 Gene

    Size:
    413 amino acids
    Molecular mass:
    47663 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15462.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZDHHC6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZDHHC6 Gene

Proteomics data for ZDHHC6 Gene at MOPED

Post-translational modifications for ZDHHC6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZDHHC6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for ZDHHC6 Gene

Gene Families for ZDHHC6 Gene

HGNC:
  • ZDHHC :Zinc fingers, DHHC-type

Protein Domains for ZDHHC6 Gene

UniProtKB/Swiss-Prot:

ZDHC6_HUMAN
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.:
    • Q9H6R6
Family:
  • Belongs to the DHHC palmitoyltransferase family.:
    • Q9H6R6
Similarity:
  • Contains 1 DHHC-type zinc finger.:
    • Q9H6R6
genes like me logo Genes that share domains with ZDHHC6: view

Function for ZDHHC6 Gene

Molecular function for ZDHHC6 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
UniProtKB/Swiss-Prot Function: Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins.

Enzyme Numbers (IUBMB) for ZDHHC6 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016409 palmitoyltransferase activity IDA 23034182
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC6: view

Phenotypes for ZDHHC6 Gene

GenomeRNAi human phenotypes for ZDHHC6:
genes like me logo Genes that share phenotypes with ZDHHC6: view

miRNA for ZDHHC6 Gene

miRTarBase miRNAs that target ZDHHC6

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ZDHHC6 Gene

Localization for ZDHHC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC6 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZDHHC6 Gene COMPARTMENTS Subcellular localization image for ZDHHC6 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ZDHHC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 16647879
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC6: view

Pathways for ZDHHC6 Gene

SuperPathways for ZDHHC6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018345 protein palmitoylation IDA 23034182
genes like me logo Genes that share ontologies with ZDHHC6: view

No data available for Pathways by source for ZDHHC6 Gene

Transcripts for ZDHHC6 Gene

Unigene Clusters for ZDHHC6 Gene

Zinc finger, DHHC-type containing 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
SP1: - - - - - -
SP2: - - - - - - -
SP3:
SP4: - - -
SP5:
SP6: -
SP7:
SP8: - -

Relevant External Links for ZDHHC6 Gene

GeneLoc Exon Structure for
ZDHHC6
ECgene alternative splicing isoforms for
ZDHHC6

Expression for ZDHHC6 Gene

mRNA expression in normal human tissues for ZDHHC6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZDHHC6 Gene

SOURCE GeneReport for Unigene cluster for ZDHHC6 Gene Hs.196990

genes like me logo Genes that share expressions with ZDHHC6: view

Orthologs for ZDHHC6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZDHHC6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC6 36
  • 99.6 (n)
  • 100 (a)
ZDHHC6 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZDHHC6 36
  • 92.49 (n)
  • 95.88 (a)
ZDHHC6 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZDHHC6 36
  • 93.14 (n)
  • 95.88 (a)
ZDHHC6 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zdhhc6 36
  • 89.02 (n)
  • 92.74 (a)
Zdhhc6 16
Zdhhc6 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZDHHC6 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC6 37
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zdhhc6 36
  • 88.46 (n)
  • 92.49 (a)
chicken
(Gallus gallus)
Aves ZDHHC6 36
  • 78.71 (n)
  • 82.69 (a)
ZDHHC6 37
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZDHHC6 37
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC52647 36
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc6 36
  • 70.93 (n)
  • 77.4 (a)
zebrafish
(Danio rerio)
Actinopterygii wufa04d12 36
zdhhc6 36
  • 68.61 (n)
  • 73.54 (a)
zdhhc6 37
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000886 36
  • 51.48 (n)
  • 44.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4483 37
  • 36 (a)
OneToMany
CG5196 36
  • 49.17 (n)
  • 42.54 (a)
CG5196 37
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dhhc-6 37
  • 33 (a)
OneToOne
M18.8 36
  • 50.84 (n)
  • 39.84 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PFA3 37
  • 21 (a)
OneToMany
PFA4 39
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G09320 36
  • 48.73 (n)
  • 37.14 (a)
rice
(Oryza sativa)
Liliopsida Os05g0458000 36
  • 46.17 (n)
  • 37.43 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1887 36
Species with no ortholog for ZDHHC6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC6 Gene

ENSEMBL:
Gene Tree for ZDHHC6 (if available)
TreeFam:
Gene Tree for ZDHHC6 (if available)

Paralogs for ZDHHC6 Gene

Paralogs for ZDHHC6 Gene

Pseudogenes.org Pseudogenes for ZDHHC6 Gene

genes like me logo Genes that share paralogs with ZDHHC6: view

Variants for ZDHHC6 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC6 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs2290963 -- 112,430,533(+) AAAAT(C/T)CTACA utr-variant-3-prime
rs2290964 -- 112,430,534(+) AAATC(C/T)TACAG utr-variant-3-prime
rs2290965 -- 112,430,594(+) GAAGA(C/G)GTGGT utr-variant-3-prime
rs2306158 -- 112,432,527(+) CTGTC(A/G)TCAGT intron-variant
rs2306159 -- 112,440,597(+) AACAA(A/G)GTGGT reference, synonymous-codon, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC6 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
nsv831990 CNV Loss 17160897
nsv831991 CNV Loss 17160897
esv2741029 CNV Deletion 23290073
esv2741040 CNV Deletion 23290073

Relevant External Links for ZDHHC6 Gene

HapMap Linkage Disequilibrium report
ZDHHC6

Disorders for ZDHHC6 Gene

Relevant External Links for ZDHHC6

Genetic Association Database (GAD)
ZDHHC6
Human Genome Epidemiology (HuGE) Navigator
ZDHHC6
genes like me logo Genes that share disorders with ZDHHC6: view

No data available for UniProtKB/Swiss-Prot for ZDHHC6 Gene

Publications for ZDHHC6 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  5. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. (PMID: 16647879) Ohno Y. … Igarashi Y. (Biochim. Biophys. Acta 2006) 3

Products for ZDHHC6 Gene

Sources for ZDHHC6 Gene

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