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Aliases for ZDHHC5 Gene

Aliases for ZDHHC5 Gene

  • Zinc Finger DHHC-Type Containing 5 2 3 5
  • Zinc Finger DHHC Domain-Containing Protein 5 3 4
  • Zinc Finger Protein 375 3 4
  • DHHC-5 3 4
  • ZNF375 3 4
  • Membrane-Associated DHHC5 Zinc Finger Protein 3
  • Zinc Finger, DHHC Domain Containing 5 3
  • Probable Palmitoyltransferase ZDHHC5 3
  • Palmitoyltransferase ZDHHC5 3
  • EC 4
  • KIAA1748 4
  • EC 2.3.1 56
  • DHHC5 3

External Ids for ZDHHC5 Gene

Previous GeneCards Identifiers for ZDHHC5 Gene

  • GC11P059829
  • GC11P058948
  • GC11P057686
  • GC11P057210
  • GC11P057192
  • GC11P057435
  • GC11P053784

Summaries for ZDHHC5 Gene

GeneCards Summary for ZDHHC5 Gene

ZDHHC5 (Zinc Finger DHHC-Type Containing 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include receptor activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC8.

UniProtKB/Swiss-Prot for ZDHHC5 Gene

  • Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5. Also palmitoylates FLOT2 (By similarity).

Additional gene information for ZDHHC5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC5 Gene

Genomics for ZDHHC5 Gene

GeneHancer (GH) Regulatory Elements for ZDHHC5 Gene

Promoters and enhancers for ZDHHC5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I057666 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.7 713 4.6 HDGF PKNOX1 CLOCK SMAD1 FOXA2 ARNT ARID4B SIN3A YY1 POLR2B ZDHHC5 SSRP1 ENSG00000269570 ZFP91 MED19 YPEL4 ENSG00000254732 SELENOH BTBD18 CTNND1
GH11I057334 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 20.6 -332.2 -332152 2.7 ATF1 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF48 ETS1 E2F8 SSRP1 P2RX3 CLP1 ZDHHC5 TNKS1BP1 LRRC55 ENSG00000254662
GH11I058572 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12 +909.7 909739 9.5 CLOCK DMAP1 IRF4 YY1 E2F8 ZNF143 ZNF263 SP3 NFYC PPARGC1A LPXN ZFP91 ZFP91-CNTF ENSG00000269570 ENSG00000255008 OR5B21 CLP1 ENSG00000197254 CTNND1 ZDHHC5
GH11I057656 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.4 -10.1 -10110 2 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 YY1 ZNF766 E2F8 CLP1 ENSG00000269570 ZDHHC5 SSRP1 ENSG00000255299 MED19 YPEL4
GH11I057320 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.3 -344.1 -344060 7.1 HDGF PKNOX1 SMAD1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 TNKS1BP1 ENSG00000254662 SSRP1 CLP1 ZDHHC5 GC11P057311
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZDHHC5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZDHHC5 gene promoter:

Genomic Locations for ZDHHC5 Gene

Genomic Locations for ZDHHC5 Gene
33,441 bases
Plus strand

Genomic View for ZDHHC5 Gene

Genes around ZDHHC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC5 Gene

Proteins for ZDHHC5 Gene

  • Protein details for ZDHHC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Palmitoyltransferase ZDHHC5
    Protein Accession:
    Secondary Accessions:
    • Q2TGF0
    • Q6ZMF0
    • Q8TAK8
    • Q9H923
    • Q9UFI7

    Protein attributes for ZDHHC5 Gene

    715 amino acids
    Molecular mass:
    77545 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB21839.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD18778.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZDHHC5 Gene


neXtProt entry for ZDHHC5 Gene

Selected DME Specific Peptides for ZDHHC5 Gene


Post-translational modifications for ZDHHC5 Gene

No Post-translational modifications

Domains & Families for ZDHHC5 Gene

Gene Families for ZDHHC5 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ZDHHC5 Gene

Suggested Antigen Peptide Sequences for ZDHHC5 Gene

Graphical View of Domain Structure for InterPro Entry



  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
genes like me logo Genes that share domains with ZDHHC5: view

Function for ZDHHC5 Gene

Molecular function for ZDHHC5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
UniProtKB/Swiss-Prot Function:
Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5. Also palmitoylates FLOT2 (By similarity).

Enzyme Numbers (IUBMB) for ZDHHC5 Gene

Phenotypes From GWAS Catalog for ZDHHC5 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016409 palmitoyltransferase activity IEA,IDA 22325201
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC5: view
genes like me logo Genes that share phenotypes with ZDHHC5: view

Animal Model Products

miRNA for ZDHHC5 Gene

miRTarBase miRNAs that target ZDHHC5

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC5 Gene

Localization for ZDHHC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC5 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytosol 2
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZDHHC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005886 plasma membrane IDA,IEA 16647879
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with ZDHHC5: view

Pathways & Interactions for ZDHHC5 Gene

SuperPathways for ZDHHC5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018345 protein palmitoylation IDA,IEA 22325201
genes like me logo Genes that share ontologies with ZDHHC5: view

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC5 Gene

Drugs & Compounds for ZDHHC5 Gene

(1) Drugs for ZDHHC5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0

(1) Additional Compounds for ZDHHC5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZDHHC5: view

Transcripts for ZDHHC5 Gene

Unigene Clusters for ZDHHC5 Gene

Zinc finger, DHHC-type containing 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b
SP1: - - -
SP2: - - - - -
SP4: - -
SP5: - - - - - -
SP6: -

Relevant External Links for ZDHHC5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZDHHC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZDHHC5 Gene

Protein differential expression in normal tissues from HIPED for ZDHHC5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.0), Plasma (11.8), Placenta (9.5), and Colon muscle (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZDHHC5 Gene

Protein tissue co-expression partners for ZDHHC5 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZDHHC5 Gene:


SOURCE GeneReport for Unigene cluster for ZDHHC5 Gene:


Evidence on tissue expression from TISSUES for ZDHHC5 Gene

  • Liver(4.3)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZDHHC5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC5 Gene

Orthologs for ZDHHC5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZDHHC5 33 34
  • 99.49 (n)
(Canis familiaris)
Mammalia ZDHHC5 33
  • 94.08 (n)
(Mus musculus)
Mammalia Zdhhc5 33 16 34
  • 92.54 (n)
(Rattus norvegicus)
Mammalia Zdhhc5 33
  • 92.49 (n)
(Monodelphis domestica)
Mammalia ZDHHC5 34
  • 88 (a)
(Bos Taurus)
Mammalia ZDHHC5 33 34
  • 86.32 (n)
(Ornithorhynchus anatinus)
Mammalia ZDHHC5 34
  • 81 (a)
(Gallus gallus)
Aves ZDHHC5 33 34
  • 76.69 (n)
(Anolis carolinensis)
Reptilia ZDHHC5 34
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc5 33
  • 64.82 (n)
Str.15608 33
(Danio rerio)
Actinopterygii zdhhc5a 33 34
  • 60.77 (n)
ZDHHC5 (2 of 2) 34
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34449 34
  • 24 (a)
(Caenorhabditis elegans)
Secernentea Y39E4B.7 35
  • 48 (a)
dhhc-8 34
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWF1 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 49 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8844 33
Species where no ortholog for ZDHHC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC5 Gene

Gene Tree for ZDHHC5 (if available)
Gene Tree for ZDHHC5 (if available)

Paralogs for ZDHHC5 Gene

(8) SIMAP similar genes for ZDHHC5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZDHHC5: view

Variants for ZDHHC5 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC5 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000013660 -- 57,678,593(+) C/G intron_variant
rs1000125999 -- 57,670,094(+) A/G intron_variant
rs1000151027 -- 57,684,266(+) C/T intron_variant
rs1000218276 -- 57,669,796(+) T/G intron_variant
rs1000311952 -- 57,676,740(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC5 Gene

Variant ID Type Subtype PubMed ID
esv3579728 CNV loss 25503493
nsv508633 CNV deletion 20534489
nsv832163 CNV gain 17160897
nsv832164 CNV loss 17160897

Variation tolerance for ZDHHC5 Gene

Residual Variation Intolerance Score: 21.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.26; 40.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZDHHC5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC5 Gene

Disorders for ZDHHC5 Gene

Additional Disease Information for ZDHHC5

No disorders were found for ZDHHC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC5 Gene

Publications for ZDHHC5 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase. (PMID: 21820437) Kokkola T … Kreienkamp HJ (FEBS letters 2011) 3 4 58
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for ZDHHC5 Gene

Sources for ZDHHC5 Gene

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