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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZDHHC5 Gene

protein-coding   GIFtS: 51
GCID: GC11P057435

zinc finger, DHHC-type containing 5

 Explore 1 disease affiliated with
ZDHHC5 via our new
 Human Malady Compendium 
Biological research products
for ZDHHC5
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger, DHHC-Type Containing 51 2     Membrane-Associated DHHC5 Zinc Finger Protein2
ZNF3751 2 3     Palmitoyltransferase ZDHHC52
KIAA17481 3     Probable Palmitoyltransferase ZDHHC52
Zinc Finger DHHC Domain-Containing Protein 52 3     Zinc Finger, DHHC Domain Containing 52
Zinc Finger Protein 3752 3     EC 2.3.1.-3
DHHC-52 3     EC 2.3.18
DHHC52     

External Ids:    HGNC: 184721   Entrez Gene: 259212   Ensembl: ENSG000001565997   OMIM: 6145865   UniProtKB: Q9C0B53   

Export aliases for ZDHHC5 gene to outside databases

Previous GC identifers: GC11P059829 GC11P058948 GC11P057686 GC11P057210 GC11P057192 GC11P053784


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZDHC5_HUMAN, Q9C0B5
Function: Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5. Also palmitoylates FLOT2 (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZDHHC5 gene promoter:
         C/EBPbeta   AP-1   MIF-1   AREB6   CREB   IRF-2   deltaCREB   FOXJ2 (long isoform)   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZDHHC5 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZDHHC5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZDHHC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q13.1

ZDHHC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZDHHC5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P057435:  view genomic region     (about GC identifiers)

Start:
57,435,219 bp from pter      End:
57,468,659 bp from pter
Size:
33,441 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZDHC5_HUMAN, Q9C0B5 (See protein sequence)
Recommended Name: Palmitoyltransferase ZDHHC5  
Size: 715 amino acids; 77545 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity)
Sequence caution: Sequence=BAB21839.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAD18778.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q2TGF0 Q6ZMF0 Q8TAK8 Q9H923 Q9UFI7
Alternative splicing: 2 isoforms:  Q9C0B5-1   Q9C0B5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZDHHC5: NX_Q9C0B5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9C0B5

  • 4/20 DME Specific Peptides for ZDHHC5 (Q9C0B5) (see all 20)
     WVNNCIG  PPFLRPE  FGLLYVL  SYSSQKA 

    ZDHHC5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_056272.2  
    ENSEMBL proteins: 
     ENSP00000432202   ENSP00000287169   ENSP00000431209   ENSP00000435593   ENSP00000435722  

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    Uscn Proteins for ZDHHC5

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--


    ZDHHC5 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZDHHC5 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001594 Znf_DHHC_palmitoyltrfase

    Graphical View of Domain Structure for InterPro Entry Q9C0B5

    ProtoNet protein and cluster: Q9C0B5

    1 Blocks protein family: IPB001594 Zn-finger

    UniProtKB/Swiss-Prot: ZDHC5_HUMAN, Q9C0B5
    Domain: The DHHC domain is required for palmitoyltransferase activity (By similarity)
    Similarity: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily
    Similarity: Contains 1 DHHC-type zinc finger


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ZDHC5_HUMAN, Q9C0B5
    Function: Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5. Also palmitoylates FLOT2 (By similarity)
    Catalytic activity: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA

    Enzyme Numbers (IUBMB): EC 2.3.12 EC 2.3.1.-1

    miRNA
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    hsa-miR-642a hsa-miR-218-1* hsa-miR-29a hsa-miR-25 hsa-miR-374a hsa-miR-29b-1* hsa-miR-3167 hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmidZDHHC5 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016409palmitoyltransferase activity IDA--
    GO:0016746transferase activity, transferring acyl groups ----


    ZDHHC5 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ZDHHC5:
     Cell division defect  Decreased Wnt reporter activit 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZDHHC5

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for ZDHHC5 (Q9C0B53 ENSP000002871694) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SSTR5P353463I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0018345protein palmitoylation IDA--


    ZDHHC5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZDHHC5
    Search CenterWatch for drugs/clinical trials and news about ZDHHC5 / ZDHC5 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZDHHC5 gene: 
    NM_015457.2  

    Unigene Cluster for ZDHHC5:

    Zinc finger, DHHC-type containing 5
    Hs.27239  [show with all ESTs]
    Unigene Representative Sequence: AY894889
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527985 ENST00000287169(uc001nkx.1 uc001nky.1) ENST00000528177
    ENST00000524540 ENST00000527090 ENST00000532842 ENST00000529480(uc001nkz.1)
    ENST00000529447

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    8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate ZDHHC5 (see all 54):
    hsa-miR-642a hsa-miR-218-1* hsa-miR-29a hsa-miR-25 hsa-miR-374a hsa-miR-29b-1* hsa-miR-3167 hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmidZDHHC5 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AB051535.1 AK023130.1 AK172807.1 AL117662.1 AY894889.1 BC026967.1 BX647707.1 

    12 DOTS entries:

    DT.100645408  DT.455986  DT.100654374  DT.100645410  DT.91893747  DT.100645409  DT.95269994  DT.95269995 
    DT.120733924  DT.97801577  DT.86853437  DT.97795465 

    24/216 AceView cDNA sequences (see all 216):

    BU620185 AB051535 BQ053572 AW206483 BQ224748 BF064007 NM_015457 BG055881 
    BU627218 BX456375 AI520995 AI524470 BQ956925 T34017 CB045993 BM662367 
    AI906922 AK172807 CD244094 CF125801 AL551085 Z38973 BE889836 AA203170 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC5 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b
    SP1:                    -     -                 -                                                                                 
    SP2:                    -     -     -     -     -                                                                                 
    SP3:                                                                                                                              
    SP4:                                                              -     -                                                         
    SP5:                    -     -     -     -     -     -                                                                           


    ECgene alternative splicing isoforms for ZDHHC5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZDHHC5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCAAAAACGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ZDHHC5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZDHHC5

    SOURCE GeneReport for Unigene cluster: Hs.27239
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZDHHC5 gene from 6/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ZDHHC51 zinc finger, DHHC-type containing 5 76.87(n)
    84.97(a)
      423130  NM_001039600.1  NP_001034689.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZDHHC56
    --
    86(a)
    1 ↔ 1
    1(91538747-91567798)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.156082 Transcribed sequences 71.41(n)    142025671 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7925601 probable palmitoyltransferase ZDHHC5-like 64.84(n)
    67.8(a)
      792560  XM_001332070.4  XP_001332106.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG344496
    --
    18(a)
    1 → many
    X(9220691-9250260)
    worm
    (Caenorhabditis elegans)
    Secernentea Y39E4B.73   -- 48(a)   III(13178976-13185359)   --


    ENSEMBL Gene Tree for ZDHHC5 (if available)
    TreeFam Gene Tree for ZDHHC5 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZDHHC5 gene
    ZDHHC142  ZDHHC122  ZDHHC82  ZDHHC192  ZDHHC182  ZDHHC92  
    8 SIMAP similar genes for ZDHHC5 using alignment to 4 protein entries:     ZDHC5_HUMAN (see all proteins):
    ZDHHC14    ZDHHC8    ZDHHC2    ZDHHC18    ZDHHC1    ZDHHC11B
    ZDHHC3    ZDHHC7

    ZDHHC5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/567 NCBI SNPs in ZDHHC5 are shown (see all 567    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs17981741,2
    C,F,--57433742(+) GCTCAC/TGGCAA 1 -- us2k15Minor allele frequency- T:0.27NA WA 126
    rs1406501871,2
    --57433771(+) AAGCAA/GTTCTC 1 -- us2k10--------
    rs1445105571,2
    --57434007(+) TCAAGC/TGTGTT 1 -- us2k10--------
    rs4991881,2
    C,F,A,H,--57434122(-) GTAAGG/TTAAAA 1 -- us2k126Minor allele frequency- T:0.28NA EA NS WA 2714
    rs1478834361,2
    --57434230(+) TCAGGC/GAAGTG 1 -- us2k10--------
    rs1845088711,2
    --57434340(+) TTGCTA/TTTGGG 1 -- us2k10--------
    rs1489338041,2
    --57434405(+) AGTTAA/GCTCGC 1 -- us2k10--------
    rs343583361,2
    C--57434837(+) CCATC-/AAAAAA 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs116016071,2
    C,H,--57434906(+) GGTTGG/TCCAAT 1 -- us2k14Minor allele frequency- T:0.03EA NS NA 416
    rs1162721861,2
    F,--57435008(+) GAGGGG/TTTGCT 1 -- us2k11Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for ZDHHC5 (57435219 - 57468659 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ZDHHC5
         1 CNV: 4744

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZDHHC5 for disorders           About GeneDecksing

    OMIM gene information: 614586    OMIM disorders: --

    1 disease for ZDHHC5:    About MalaCards
    malaria


    Export disorders for ZDHHC5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZDHHC5 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with ZDHHC5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase. (PubMed id 21820437)1, 2 Kokkola T.... Kreienkamp H.J. (2011)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    10. Proteome scale characterization of human S-acylated p roteins in lipid raft-enriched and non-raft membranes. (PubMed id 19801377)1 Yang W....Freeman M.R. (2010)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25921 HGNC: 18472 AceView: ZDHHC5 Ensembl:ENSG00000156599 euGenes: HUgn25921
    ECgene: ZDHHC5 H-InvDB: ZDHHC5

    (According to HUGE)
    About This Section
    HUGE: KIAA1748

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZDHHC5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZDHHC5 gene:
    Search GeneIP for patents involving ZDHHC5

    GeneCards and IP:
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