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Aliases for ZDHHC5 Gene

Aliases for ZDHHC5 Gene

  • Zinc Finger, DHHC-Type Containing 5 2 3
  • Zinc Finger DHHC Domain-Containing Protein 5 3 4
  • Zinc Finger Protein 375 3 4
  • DHHC-5 3 4
  • ZNF375 3 4
  • Membrane-Associated DHHC5 Zinc Finger Protein 3
  • Zinc Finger, DHHC Domain Containing 5 3
  • Probable Palmitoyltransferase ZDHHC5 3
  • EC 2.3.1.225 4
  • KIAA1748 4
  • EC 2.3.1 63
  • DHHC5 3

External Ids for ZDHHC5 Gene

Previous GeneCards Identifiers for ZDHHC5 Gene

  • GC11P059829
  • GC11P058948
  • GC11P057686
  • GC11P057210
  • GC11P057192
  • GC11P057435
  • GC11P053784

Summaries for ZDHHC5 Gene

GeneCards Summary for ZDHHC5 Gene

ZDHHC5 (Zinc Finger, DHHC-Type Containing 5) is a Protein Coding gene. GO annotations related to this gene include receptor activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC4.

UniProtKB/Swiss-Prot for ZDHHC5 Gene

  • Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5. Also palmitoylates FLOT2 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC5 Gene

Genomics for ZDHHC5 Gene

Regulatory Elements for ZDHHC5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZDHHC5 Gene

Chromosome:
11
Start:
57,667,747 bp from pter
End:
57,701,187 bp from pter
Size:
33,441 bases
Orientation:
Plus strand

Genomic View for ZDHHC5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZDHHC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC5 Gene

Proteins for ZDHHC5 Gene

  • Protein details for ZDHHC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0B5-ZDHC5_HUMAN
    Recommended name:
    Palmitoyltransferase ZDHHC5
    Protein Accession:
    Q9C0B5
    Secondary Accessions:
    • Q2TGF0
    • Q6ZMF0
    • Q8TAK8
    • Q9H923
    • Q9UFI7

    Protein attributes for ZDHHC5 Gene

    Size:
    715 amino acids
    Molecular mass:
    77545 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB21839.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD18778.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZDHHC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZDHHC5 Gene

Proteomics data for ZDHHC5 Gene at MOPED

Post-translational modifications for ZDHHC5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZDHHC5 Gene

Domains & Families for ZDHHC5 Gene

Gene Families for ZDHHC5 Gene

Protein Domains for ZDHHC5 Gene

Suggested Antigen Peptide Sequences for ZDHHC5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9C0B5

UniProtKB/Swiss-Prot:

ZDHC5_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
  • Contains 1 DHHC-type zinc finger.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
Similarity:
  • Contains 1 DHHC-type zinc finger.
genes like me logo Genes that share domains with ZDHHC5: view

Function for ZDHHC5 Gene

Molecular function for ZDHHC5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA
UniProtKB/Swiss-Prot Function:
Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5. Also palmitoylates FLOT2 (By similarity).

Enzyme Numbers (IUBMB) for ZDHHC5 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016409 palmitoyltransferase activity IDA 22325201
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC5: view

Phenotypes for ZDHHC5 Gene

genes like me logo Genes that share phenotypes with ZDHHC5: view

Animal Model Products

miRNA for ZDHHC5 Gene

miRTarBase miRNAs that target ZDHHC5

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZDHHC5

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC5 Gene

Localization for ZDHHC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZDHHC5 Gene COMPARTMENTS Subcellular localization image for ZDHHC5 gene
Compartment Confidence
plasma membrane 5
cytosol 2
nucleus 2
endosome 1

Gene Ontology (GO) - Cellular Components for ZDHHC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005886 plasma membrane IDA 16647879
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with ZDHHC5: view

Pathways & Interactions for ZDHHC5 Gene

SuperPathways for ZDHHC5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0018345 protein palmitoylation IDA 22325201
genes like me logo Genes that share ontologies with ZDHHC5: view

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC5 Gene

Drugs & Compounds for ZDHHC5 Gene

(1) Drugs for ZDHHC5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for ZDHHC5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
genes like me logo Genes that share compounds with ZDHHC5: view

Transcripts for ZDHHC5 Gene

Unigene Clusters for ZDHHC5 Gene

Zinc finger, DHHC-type containing 5:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZDHHC5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b
SP1: - - -
SP2: - - - - -
SP3:
SP4: - -
SP5: - - - - - -
SP6: -
SP7:

Relevant External Links for ZDHHC5 Gene

GeneLoc Exon Structure for
ZDHHC5
ECgene alternative splicing isoforms for
ZDHHC5

Expression for ZDHHC5 Gene

mRNA expression in normal human tissues for ZDHHC5 Gene

Protein differential expression in normal tissues from HIPED for ZDHHC5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.0), Plasma (11.8), Placenta (9.5), and Colon muscle (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZDHHC5 Gene



SOURCE GeneReport for Unigene cluster for ZDHHC5 Gene Hs.27239

genes like me logo Genes that share expression patterns with ZDHHC5: view

Protein tissue co-expression partners for ZDHHC5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZDHHC5 Gene

Orthologs for ZDHHC5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZDHHC5 35
  • 86.32 (n)
  • 94.54 (a)
ZDHHC5 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZDHHC5 35
  • 94.08 (n)
  • 97.62 (a)
mouse
(Mus musculus)
Mammalia Zdhhc5 35
  • 92.54 (n)
  • 97.9 (a)
Zdhhc5 16
Zdhhc5 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC5 35
  • 99.49 (n)
  • 99.86 (a)
ZDHHC5 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zdhhc5 35
  • 92.49 (n)
  • 98.04 (a)
oppossum
(Monodelphis domestica)
Mammalia ZDHHC5 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC5 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZDHHC5 35
  • 76.69 (n)
  • 84.97 (a)
ZDHHC5 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZDHHC5 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15608 35
zdhhc5 35
  • 64.82 (n)
  • 69.08 (a)
zebrafish
(Danio rerio)
Actinopterygii zdhhc5a 35
  • 60.77 (n)
  • 64.63 (a)
ZDHHC5 (2 of 2) 36
  • 58 (a)
OneToMany
zdhhc5a 36
  • 57 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG34449 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y39E4B.7 37
  • 48 (a)
dhhc-8 36
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWF1 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8844 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
Species with no ortholog for ZDHHC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC5 Gene

ENSEMBL:
Gene Tree for ZDHHC5 (if available)
TreeFam:
Gene Tree for ZDHHC5 (if available)

Paralogs for ZDHHC5 Gene

(8) SIMAP similar genes for ZDHHC5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZDHHC5: view

Variants for ZDHHC5 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs472209 -- 57,691,949(-) ATCAT(G/T)GCTTT intron-variant
rs473083 -- 57,691,854(-) TCCAG(G/T)GGGCA intron-variant
rs479219 -- 57,679,716(-) ACCAC(C/G)CCAAG intron-variant
rs486014 -- 57,686,847(-) tctgg(A/G)aaaaa intron-variant
rs488769 -- 57,683,248(-) TCCTA(G/T)CCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC5 Gene

Variant ID Type Subtype PubMed ID
nsv832163 CNV Gain 17160897
nsv832164 CNV Loss 17160897
nsv508633 CNV Loss 20534489

Variation tolerance for ZDHHC5 Gene

Residual Variation Intolerance Score: 21.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.26; 40.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZDHHC5 Gene

HapMap Linkage Disequilibrium report
ZDHHC5
Human Gene Mutation Database (HGMD)
ZDHHC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC5 Gene

Disorders for ZDHHC5 Gene

Relevant External Links for ZDHHC5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZDHHC5
genes like me logo Genes that share disorders with ZDHHC5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC5 Gene

Publications for ZDHHC5 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 67
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 67

Products for ZDHHC5 Gene

Sources for ZDHHC5 Gene

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