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Aliases for ZDHHC5 Gene

Aliases for ZDHHC5 Gene

  • Zinc Finger DHHC-Type Containing 5 2 3 5
  • Zinc Finger DHHC Domain-Containing Protein 5 3 4
  • Zinc Finger Protein 375 3 4
  • DHHC-5 3 4
  • ZNF375 3 4
  • Membrane-Associated DHHC5 Zinc Finger Protein 3
  • Zinc Finger, DHHC Domain Containing 5 3
  • Probable Palmitoyltransferase ZDHHC5 3
  • Palmitoyltransferase ZDHHC5 3
  • EC 2.3.1.225 4
  • KIAA1748 4
  • EC 2.3.1 61
  • DHHC5 3

External Ids for ZDHHC5 Gene

Previous GeneCards Identifiers for ZDHHC5 Gene

  • GC11P059829
  • GC11P058948
  • GC11P057686
  • GC11P057210
  • GC11P057192
  • GC11P057435
  • GC11P053784

Summaries for ZDHHC5 Gene

GeneCards Summary for ZDHHC5 Gene

ZDHHC5 (Zinc Finger DHHC-Type Containing 5) is a Protein Coding gene. GO annotations related to this gene include receptor activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC8.

UniProtKB/Swiss-Prot for ZDHHC5 Gene

  • Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5. Also palmitoylates FLOT2 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC5 Gene

Genomics for ZDHHC5 Gene

Regulatory Elements for ZDHHC5 Gene

Enhancers for ZDHHC5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F058572 1.6 FANTOM5 ENCODE 10.9 +909.7 909739 9.5 CREB3L1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 PPARGC1A MEF2D ENSG00000255008 LPXN CTNND1 OR5B21 ENSG00000197254 ENSG00000269570 CNTF ZDHHC5 ZFP91 GC11M058554
GH11F057797 1.4 Ensembl ENCODE 11 +132.9 132890 5.6 HDGF PKNOX1 MLX ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF143 FOS MED19 YPEL4 SSRP1 BTBD18 CTNND1 SELENOH ENSG00000254732 ENSG00000269570 ZDHHC5 TIMM10
GH11F057740 1.2 ENCODE 11.1 +74.1 74143 2.7 HDGF PKNOX1 ARNT MLX CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 TNKS1BP1 SSRP1 CTNND1 RPS4XP13 OR5AZ1P OR9Q2 OR5B15P OR5B1P OR5B21 MED19
GH11F057760 1.2 ENCODE 11 +95.7 95713 5.3 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 SSRP1 TNKS1BP1 MED19 YPEL4 SELENOH ENSG00000254732 ENSG00000269570 CTNND1 ZDHHC5 UBE2L6
GH11F057973 1.2 ENCODE 10.9 +306.4 306369 0.5 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TNKS1BP1 SSRP1 CTNND1 OR5AZ1P OR9Q2 RPS4XP13 OR5B1P OR5B15P OR5B21 BTBD18
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZDHHC5 on UCSC Golden Path with GeneCards custom track

Promoters for ZDHHC5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000562734 253 2801 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A YY1 ZNF766 CBX5

Genomic Location for ZDHHC5 Gene

Chromosome:
11
Start:
57,667,747 bp from pter
End:
57,701,187 bp from pter
Size:
33,441 bases
Orientation:
Plus strand

Genomic View for ZDHHC5 Gene

Genes around ZDHHC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC5 Gene

Proteins for ZDHHC5 Gene

  • Protein details for ZDHHC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0B5-ZDHC5_HUMAN
    Recommended name:
    Palmitoyltransferase ZDHHC5
    Protein Accession:
    Q9C0B5
    Secondary Accessions:
    • Q2TGF0
    • Q6ZMF0
    • Q8TAK8
    • Q9H923
    • Q9UFI7

    Protein attributes for ZDHHC5 Gene

    Size:
    715 amino acids
    Molecular mass:
    77545 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB21839.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD18778.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZDHHC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZDHHC5 Gene

Selected DME Specific Peptides for ZDHHC5 Gene

Q9C0B5:
  • FYRPPRCSHCSVCDNCVE
  • PRFGKPDGLRGRG
  • WVNNCIG
  • FGLLYVL
  • REPSPVRYDNLSR
  • VSPAVPIYNAI
  • FLFVLANFSMATFMDPG
  • VTGKFRGGVNPFT
  • SSRHPSYRSEPSLEPESFRSPTFGKSFHFDPLSSGSRSS
  • TMAVMCVAGLFFIPV
  • RGRTTNE
  • EDEDKEDDFRAPLYK
  • GSASPGPGQ
  • SYSSQKA
  • KDSPPTPTMYKYRPGYSSSSTSAAMPHSSSAKLSRGDSL
  • GIQVRMKWCATC
  • TAPYLGRS
  • PPFLRPE
  • TESQSADAEPPPPPKPDLSRYTGLRTHL
  • EEVALQPLLTPKDEVQLKT

Post-translational modifications for ZDHHC5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ZDHHC5 Gene

Gene Families for ZDHHC5 Gene

Protein Domains for ZDHHC5 Gene

Suggested Antigen Peptide Sequences for ZDHHC5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9C0B5

UniProtKB/Swiss-Prot:

ZDHC5_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
  • Contains 1 DHHC domain.
Family:
  • Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
genes like me logo Genes that share domains with ZDHHC5: view

Function for ZDHHC5 Gene

Molecular function for ZDHHC5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
UniProtKB/Swiss-Prot Function:
Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5. Also palmitoylates FLOT2 (By similarity).

Enzyme Numbers (IUBMB) for ZDHHC5 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016409 palmitoyltransferase activity IDA 22325201
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC5: view
genes like me logo Genes that share phenotypes with ZDHHC5: view

Animal Model Products

miRNA for ZDHHC5 Gene

miRTarBase miRNAs that target ZDHHC5

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC5 Gene

Localization for ZDHHC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC5 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytosol 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ZDHHC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005886 plasma membrane IDA 16647879
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with ZDHHC5: view

Pathways & Interactions for ZDHHC5 Gene

SuperPathways for ZDHHC5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018345 protein palmitoylation IDA 22325201
genes like me logo Genes that share ontologies with ZDHHC5: view

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC5 Gene

Drugs & Compounds for ZDHHC5 Gene

(1) Drugs for ZDHHC5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for ZDHHC5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
genes like me logo Genes that share compounds with ZDHHC5: view

Transcripts for ZDHHC5 Gene

Unigene Clusters for ZDHHC5 Gene

Zinc finger, DHHC-type containing 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b
SP1: - - -
SP2: - - - - -
SP3:
SP4: - -
SP5: - - - - - -
SP6: -
SP7:

Relevant External Links for ZDHHC5 Gene

GeneLoc Exon Structure for
ZDHHC5
ECgene alternative splicing isoforms for
ZDHHC5

Expression for ZDHHC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZDHHC5 Gene

Protein differential expression in normal tissues from HIPED for ZDHHC5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.0), Plasma (11.8), Placenta (9.5), and Colon muscle (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZDHHC5 Gene



Protein tissue co-expression partners for ZDHHC5 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZDHHC5 Gene:

ZDHHC5

SOURCE GeneReport for Unigene cluster for ZDHHC5 Gene:

Hs.27239
genes like me logo Genes that share expression patterns with ZDHHC5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZDHHC5 Gene

Orthologs for ZDHHC5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC5 34 35
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia ZDHHC5 34
  • 94.08 (n)
mouse
(Mus musculus)
Mammalia Zdhhc5 34 16 35
  • 92.54 (n)
rat
(Rattus norvegicus)
Mammalia Zdhhc5 34
  • 92.49 (n)
oppossum
(Monodelphis domestica)
Mammalia ZDHHC5 35
  • 88 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZDHHC5 34 35
  • 86.32 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC5 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZDHHC5 34 35
  • 76.69 (n)
lizard
(Anolis carolinensis)
Reptilia ZDHHC5 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc5 34
  • 64.82 (n)
Str.15608 34
zebrafish
(Danio rerio)
Actinopterygii zdhhc5a 34 35
  • 60.77 (n)
ZDHHC5 (2 of 2) 35
  • 58 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG34449 35
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y39E4B.7 36
  • 48 (a)
dhhc-8 35
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWF1 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 49 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8844 34
Species where no ortholog for ZDHHC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC5 Gene

ENSEMBL:
Gene Tree for ZDHHC5 (if available)
TreeFam:
Gene Tree for ZDHHC5 (if available)

Paralogs for ZDHHC5 Gene

Paralogs for ZDHHC5 Gene

(8) SIMAP similar genes for ZDHHC5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZDHHC5: view

Variants for ZDHHC5 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10561191 -- 57,689,698(+) GCCAA(-/T)TTTTT intron-variant
rs10589895 -- 57,667,389(+) CCATC(-/A)AAAAA upstream-variant-2KB
rs10633679 -- 57,700,414(+) TATAT(-/AT)TATAA nc-transcript-variant, utr-variant-3-prime
rs10896634 -- 57,667,783(+) GTACG(G/T)CGTTG upstream-variant-2KB
rs10896635 -- 57,671,222(+) ATAAT(A/G)TGAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC5 Gene

Variant ID Type Subtype PubMed ID
nsv832164 CNV loss 17160897
nsv832163 CNV gain 17160897
nsv508633 CNV deletion 20534489
esv3579728 CNV loss 25503493

Variation tolerance for ZDHHC5 Gene

Residual Variation Intolerance Score: 21.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.26; 40.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZDHHC5 Gene

Human Gene Mutation Database (HGMD)
ZDHHC5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZDHHC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC5 Gene

Disorders for ZDHHC5 Gene

Relevant External Links for ZDHHC5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZDHHC5

No disorders were found for ZDHHC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC5 Gene

Publications for ZDHHC5 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  2. Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase. (PMID: 21820437) Kokkola T. … Kreienkamp H.J. (FEBS Lett. 2011) 3 4 64
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ZDHHC5 Gene

Sources for ZDHHC5 Gene

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