Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZDHHC5 Gene

Aliases for ZDHHC5 Gene

  • Zinc Finger, DHHC-Type Containing 5 2 3
  • ZNF375 3 4 6
  • Zinc Finger DHHC Domain-Containing Protein 5 3 4
  • Zinc Finger Protein 375 3 4
  • KIAA1748 4 6
  • DHHC-5 3 4
  • DHHC5 3 6
  • Membrane-Associated DHHC5 Zinc Finger Protein 3
  • Zinc Finger, DHHC Domain Containing 5 3
  • Probable Palmitoyltransferase ZDHHC5 3
  • Palmitoyltransferase ZDHHC5 3
  • EC 4
  • EC 2.3.1 63

External Ids for ZDHHC5 Gene

Previous GeneCards Identifiers for ZDHHC5 Gene

  • GC11P059829
  • GC11P058948
  • GC11P057686
  • GC11P057210
  • GC11P057192
  • GC11P057435
  • GC11P053784

Summaries for ZDHHC5 Gene

GeneCards Summary for ZDHHC5 Gene

ZDHHC5 (Zinc Finger, DHHC-Type Containing 5) is a Protein Coding gene. GO annotations related to this gene include palmitoyltransferase activity. An important paralog of this gene is ZDHHC4.

UniProtKB/Swiss-Prot for ZDHHC5 Gene

  • Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5. Also palmitoylates FLOT2 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC5 Gene

Genomics for ZDHHC5 Gene

Regulatory Elements for ZDHHC5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZDHHC5 Gene

57,667,747 bp from pter
57,701,187 bp from pter
33,441 bases
Plus strand

Genomic View for ZDHHC5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZDHHC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC5 Gene

Proteins for ZDHHC5 Gene

  • Protein details for ZDHHC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Palmitoyltransferase ZDHHC5
    Protein Accession:
    Secondary Accessions:
    • Q2TGF0
    • Q6ZMF0
    • Q8TAK8
    • Q9H923
    • Q9UFI7

    Protein attributes for ZDHHC5 Gene

    715 amino acids
    Molecular mass:
    77545 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB21839.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD18778.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZDHHC5 Gene


neXtProt entry for ZDHHC5 Gene

Proteomics data for ZDHHC5 Gene at MOPED

Post-translational modifications for ZDHHC5 Gene

  • Ubiquitination at Lys224
  • Modification sites at PhosphoSitePlus

Other Protein References for ZDHHC5 Gene

Domains for ZDHHC5 Gene

Gene Families for ZDHHC5 Gene

  • ZDHHC :Zinc fingers, DHHC-type

Protein Domains for ZDHHC5 Gene

Suggested Antigen Peptide Sequences for ZDHHC5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9C0B5
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
  • Contains 1 DHHC-type zinc finger.
genes like me logo Genes that share domains with ZDHHC5: view

Function for ZDHHC5 Gene

Molecular function for ZDHHC5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA
UniProtKB/Swiss-Prot Function:
Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5. Also palmitoylates FLOT2 (By similarity).

Enzyme Numbers (IUBMB) for ZDHHC5 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016409 palmitoyltransferase activity IDA 22325201
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC5: view

Phenotypes for ZDHHC5 Gene

GenomeRNAi human phenotypes for ZDHHC5:
genes like me logo Genes that share phenotypes with ZDHHC5: view

Animal Model Products

miRNA for ZDHHC5 Gene

miRTarBase miRNAs that target ZDHHC5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZDHHC5

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ZDHHC5 Gene

Localization for ZDHHC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ZDHHC5 Gene COMPARTMENTS Subcellular localization image for ZDHHC5 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ZDHHC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 16647879
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with ZDHHC5: view

Pathways for ZDHHC5 Gene

SuperPathways for ZDHHC5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development --
GO:0008152 metabolic process --
GO:0018345 protein palmitoylation IDA 22325201
genes like me logo Genes that share ontologies with ZDHHC5: view

No data available for Pathways by source for ZDHHC5 Gene

Transcripts for ZDHHC5 Gene

Unigene Clusters for ZDHHC5 Gene

Zinc finger, DHHC-type containing 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZDHHC5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b
SP1: - - -
SP2: - - - - -
SP4: - -
SP5: - - - - - -
SP6: -

Relevant External Links for ZDHHC5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZDHHC5 Gene

mRNA expression in normal human tissues for ZDHHC5 Gene

Protein differential expression in normal tissues for ZDHHC5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.0), Plasma (11.8), Placenta (9.5), and Colon muscle (7.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZDHHC5 Gene

SOURCE GeneReport for Unigene cluster for ZDHHC5 Gene Hs.27239

genes like me logo Genes that share expressions with ZDHHC5: view

Expression partners for ZDHHC5 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZDHHC5 Gene

Orthologs for ZDHHC5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZDHHC5 35
  • 86.32 (n)
  • 94.54 (a)
  • 95 (a)
(Canis familiaris)
Mammalia ZDHHC5 35
  • 94.08 (n)
  • 97.62 (a)
(Mus musculus)
Mammalia Zdhhc5 35
  • 92.54 (n)
  • 97.9 (a)
Zdhhc5 16
Zdhhc5 36
  • 98 (a)
(Pan troglodytes)
Mammalia ZDHHC5 35
  • 99.49 (n)
  • 99.86 (a)
  • 96 (a)
(Rattus norvegicus)
Mammalia Zdhhc5 35
  • 92.49 (n)
  • 98.04 (a)
(Monodelphis domestica)
Mammalia ZDHHC5 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia ZDHHC5 36
  • 81 (a)
(Gallus gallus)
Aves ZDHHC5 35
  • 76.69 (n)
  • 84.97 (a)
  • 81 (a)
(Anolis carolinensis)
Reptilia ZDHHC5 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15608 35
zdhhc5 35
  • 64.82 (n)
  • 69.08 (a)
(Danio rerio)
Actinopterygii zdhhc5a 35
  • 60.77 (n)
  • 64.63 (a)
ZDHHC5 (2 of 2) 36
  • 58 (a)
zdhhc5a 36
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34449 36
  • 24 (a)
(Caenorhabditis elegans)
Secernentea Y39E4B.7 37
  • 48 (a)
dhhc-8 36
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWF1 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8844 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
Species with no ortholog for ZDHHC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC5 Gene

Gene Tree for ZDHHC5 (if available)
Gene Tree for ZDHHC5 (if available)

Paralogs for ZDHHC5 Gene

Selected SIMAP similar genes for ZDHHC5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZDHHC5: view

Variants for ZDHHC5 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs472209 -- 57,691,949(-) ATCAT(G/T)GCTTT intron-variant
rs473083 -- 57,691,854(-) TCCAG(G/T)GGGCA intron-variant
rs479219 -- 57,679,716(-) ACCAC(C/G)CCAAG intron-variant
rs486014 -- 57,686,847(-) tctgg(A/G)aaaaa intron-variant
rs488769 -- 57,683,248(-) TCCTA(G/T)CCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC5 Gene

Variant ID Type Subtype PubMed ID
nsv832163 CNV Gain 17160897
nsv832164 CNV Loss 17160897
nsv508633 CNV Loss 20534489

Relevant External Links for ZDHHC5 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC5 Gene

Disorders for ZDHHC5 Gene

No disorders were found for ZDHHC5 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ZDHHC5 Gene

Publications for ZDHHC5 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase. (PMID: 21820437) Kokkola T. … Kreienkamp H.J. (FEBS Lett. 2011) 3 4

Products for ZDHHC5 Gene

Sources for ZDHHC5 Gene

Back to Top