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Aliases for ZDHHC4 Gene

Aliases for ZDHHC4 Gene

  • Zinc Finger DHHC-Type Containing 4 2 3
  • Zinc Finger DHHC Domain-Containing Protein 4 3 4
  • Zinc Finger, DHHC-Type Containing 4 3 5
  • Zinc Finger Protein 374 3 4
  • DHHC-4 3 4
  • ZNF374 3 4
  • Zinc Finger, DHHC Domain Containing 4 3
  • EC 4
  • EC 2.3.1 63

External Ids for ZDHHC4 Gene

Previous GeneCards Identifiers for ZDHHC4 Gene

  • GC07P006261
  • GC07P006361
  • GC07P006362
  • GC07P006390

Summaries for ZDHHC4 Gene

GeneCards Summary for ZDHHC4 Gene

ZDHHC4 (Zinc Finger DHHC-Type Containing 4) is a Protein Coding gene. GO annotations related to this gene include cytochrome-c oxidase activity and protein-cysteine S-palmitoyltransferase activity. An important paralog of this gene is ZDHHC1.

Gene Wiki entry for ZDHHC4 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC4 Gene

Genomics for ZDHHC4 Gene

Regulatory Elements for ZDHHC4 Gene

Promoters for ZDHHC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZDHHC4 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZDHHC4 Gene

6,577,412 bp from pter
6,589,374 bp from pter
11,963 bases
Plus strand

Genomic View for ZDHHC4 Gene

Genes around ZDHHC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC4 Gene

Proteins for ZDHHC4 Gene

  • Protein details for ZDHHC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable palmitoyltransferase ZDHHC4
    Protein Accession:
    Secondary Accessions:
    • A4D2N9
    • Q53EV7
    • Q6FIB5
    • Q9H0R9

    Protein attributes for ZDHHC4 Gene

    344 amino acids
    Molecular mass:
    39787 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZDHHC4 Gene

Proteomics data for ZDHHC4 Gene at MOPED

Selected DME Specific Peptides for ZDHHC4 Gene

Post-translational modifications for ZDHHC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ZDHHC4 Gene

Gene Families for ZDHHC4 Gene

Protein Domains for ZDHHC4 Gene

Suggested Antigen Peptide Sequences for ZDHHC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
  • Contains 1 DHHC-type zinc finger.
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
  • Contains 1 DHHC-type zinc finger.
genes like me logo Genes that share domains with ZDHHC4: view

Function for ZDHHC4 Gene

Molecular function for ZDHHC4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Enzyme Numbers (IUBMB) for ZDHHC4 Gene

genes like me logo Genes that share phenotypes with ZDHHC4: view

Animal Model Products

miRNA for ZDHHC4 Gene

miRTarBase miRNAs that target ZDHHC4

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC4 Gene

Localization for ZDHHC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ZDHHC4 Gene COMPARTMENTS Subcellular localization image for ZDHHC4 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for ZDHHC4 Gene

Pathways & Interactions for ZDHHC4 Gene

SuperPathways for ZDHHC4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC4 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZDHHC4 Gene

Drugs & Compounds for ZDHHC4 Gene

(1) Drugs for ZDHHC4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for ZDHHC4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZDHHC4: view

Transcripts for ZDHHC4 Gene

Unigene Clusters for ZDHHC4 Gene

Zinc finger, DHHC-type containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - - - -
SP8: - - - - - -
SP9: - -
SP10: - - - - -

Relevant External Links for ZDHHC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZDHHC4 Gene

mRNA expression in normal human tissues for ZDHHC4 Gene

Protein differential expression in normal tissues from HIPED for ZDHHC4 Gene

This gene is overexpressed in Ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZDHHC4 Gene

SOURCE GeneReport for Unigene cluster for ZDHHC4 Gene Hs.5268

genes like me logo Genes that share expression patterns with ZDHHC4: view

Protein tissue co-expression partners for ZDHHC4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZDHHC4 Gene

Orthologs for ZDHHC4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZDHHC4 35
  • 99.03 (n)
  • 98.26 (a)
  • 98 (a)
(Bos Taurus)
Mammalia ZDHHC4 36
  • 79 (a)
  • 84.16 (n)
  • 79.59 (a)
(Canis familiaris)
Mammalia ZDHHC4 35
  • 83.19 (n)
  • 77.26 (a)
  • 64 (a)
(Mus musculus)
Mammalia Zdhhc4 16
Zdhhc4 36
  • 74 (a)
Zdhhc4 35
  • 79.01 (n)
  • 73.76 (a)
(Monodelphis domestica)
Mammalia ZDHHC4 36
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia ZDHHC4 36
  • 57 (a)
(Rattus norvegicus)
Mammalia Zdhhc4 35
  • 78.43 (n)
  • 71.14 (a)
(Gallus gallus)
Aves ZDHHC4 36
  • 50 (a)
  • 61.11 (n)
  • 53.49 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18776 35
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc4 35
  • 58.2 (n)
  • 49.23 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5703 35
(Danio rerio)
Actinopterygii zdhhc4 36
  • 45 (a)
wufa97b04 35
zdhhc4 35
  • 53.02 (n)
  • 45.32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERF2 36
  • 19 (a)
Species with no ortholog for ZDHHC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZDHHC4 Gene

Gene Tree for ZDHHC4 (if available)
Gene Tree for ZDHHC4 (if available)

Paralogs for ZDHHC4 Gene

Paralogs for ZDHHC4 Gene Pseudogenes for ZDHHC4 Gene

genes like me logo Genes that share paralogs with ZDHHC4: view

Variants for ZDHHC4 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs11559146 - 6,581,646(+) GAGCC(A/G)TGCAT reference, missense
VAR_036260 A breast cancer sample
rs1880119 -- 6,575,809(-) AGCTG(A/T)GGTGG upstream-variant-2KB
rs4075107 -- 6,582,506(-) CATAC(C/G)GATCA intron-variant
rs4336516 -- 6,585,460(+) AACTG(A/C)TGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC4 Gene

Variant ID Type Subtype PubMed ID
nsv436904 CNV Insertion 17901297
nsv7392 OTHER Inversion 18451855
esv1914954 OTHER Inversion 16254605
nsv830895 CNV Loss 17160897
dgv7147n71 CNV Loss 21882294
nsv508444 CNV Loss 20534489
nsv515978 CNV Loss 19592680
dgv7148n71 CNV Loss 21882294
dgv7149n71 CNV Loss 21882294
esv2123966 CNV Deletion 18987734
dgv1090n67 CNV Gain 20364138

Variation tolerance for ZDHHC4 Gene

Residual Variation Intolerance Score: 66.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.81; 58.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZDHHC4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC4 Gene

Disorders for ZDHHC4 Gene

Relevant External Links for ZDHHC4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZDHHC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC4 Gene

Publications for ZDHHC4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. (PMID: 16647879) Ohno Y. … Igarashi Y. (Biochim. Biophys. Acta 2006) 3
  3. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A. … Carmell M.A. (Nature 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3

Products for ZDHHC4 Gene

Sources for ZDHHC4 Gene

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