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Aliases for ZDHHC4 Gene

Aliases for ZDHHC4 Gene

  • Zinc Finger DHHC-Type Containing 4 2 3 5
  • Zinc Finger DHHC Domain-Containing Protein 4 3 4
  • Zinc Finger Protein 374 3 4
  • DHHC-4 3 4
  • ZNF374 3 4
  • Zinc Finger, DHHC Domain Containing 4 3
  • Probable Palmitoyltransferase ZDHHC4 3
  • EC 2.3.1.225 4
  • EC 2.3.1 61

External Ids for ZDHHC4 Gene

Previous GeneCards Identifiers for ZDHHC4 Gene

  • GC07P006261
  • GC07P006361
  • GC07P006362
  • GC07P006390

Summaries for ZDHHC4 Gene

GeneCards Summary for ZDHHC4 Gene

ZDHHC4 (Zinc Finger DHHC-Type Containing 4) is a Protein Coding gene. GO annotations related to this gene include cytochrome-c oxidase activity and protein-cysteine S-palmitoyltransferase activity. An important paralog of this gene is ZDHHC1.

Gene Wiki entry for ZDHHC4 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC4 Gene

Genomics for ZDHHC4 Gene

Regulatory Elements for ZDHHC4 Gene

Enhancers for ZDHHC4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F006576 1.1 ENCODE 23 +0.1 121 2.8 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 ZDHHC4 PMS2 CCZ1B PIR51415
GH07F006589 1 ENCODE 23.7 +12.9 12864 2.0 PKNOX1 ATF1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 ZNF121 ELK1 ZDHHC4 PIR44448 PIR59555 GC07P006591
GH07F006545 1.1 Ensembl ENCODE 19.3 -31.3 -31272 1.9 ELF3 HDAC1 ZNF143 THAP11 HCFC1 NFYC ZEB2 HDAC8 POLR2H ZNF589 ZDHHC4 KDELR2 C7orf26 ENSG00000232581 CCZ1B GRID2IP LOC101927325
GH07F006636 1.4 FANTOM5 ENCODE 12.2 +60.4 60369 2.8 HDGF ATF1 ARID4B SIN3A ZNF48 GLIS2 CBX5 ELK1 ZNF143 KDM4B C7orf26 ENSG00000232581 ZDHHC4 ENSG00000198580 PMS2CL PMS2 ZNF12 DAGLB ZNF316 GC07P006652
GH07F006724 1 Ensembl ENCODE 16.5 +147.7 147689 1.4 HDGF PKNOX1 MTA2 CBFB CHD1 EP300 SP1 RAD51 EED IKZF1 PMS2 ZDHHC4 ENSG00000198580 C7orf26 ENSG00000232581 PMS2CL ZNF12 SPDYE20P PIR60249
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZDHHC4 on UCSC Golden Path with GeneCards custom track

Promoters for ZDHHC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001557145 88 1801 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 SP3 SP5

Genomic Location for ZDHHC4 Gene

Chromosome:
7
Start:
6,577,412 bp from pter
End:
6,589,374 bp from pter
Size:
11,963 bases
Orientation:
Plus strand

Genomic View for ZDHHC4 Gene

Genes around ZDHHC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC4 Gene

Proteins for ZDHHC4 Gene

  • Protein details for ZDHHC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPG8-ZDHC4_HUMAN
    Recommended name:
    Probable palmitoyltransferase ZDHHC4
    Protein Accession:
    Q9NPG8
    Secondary Accessions:
    • A4D2N9
    • Q53EV7
    • Q6FIB5
    • Q9H0R9

    Protein attributes for ZDHHC4 Gene

    Size:
    344 amino acids
    Molecular mass:
    39787 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZDHHC4 Gene

Selected DME Specific Peptides for ZDHHC4 Gene

Q9NPG8:
  • WVNNCIG
  • KPARSKH

Post-translational modifications for ZDHHC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ZDHHC4 Gene

Gene Families for ZDHHC4 Gene

Protein Domains for ZDHHC4 Gene

Suggested Antigen Peptide Sequences for ZDHHC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPG8

UniProtKB/Swiss-Prot:

ZDHC4_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
  • Contains 1 DHHC domain.
Family:
  • Belongs to the DHHC palmitoyltransferase family.
genes like me logo Genes that share domains with ZDHHC4: view

Function for ZDHHC4 Gene

Molecular function for ZDHHC4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Enzyme Numbers (IUBMB) for ZDHHC4 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC4: view
genes like me logo Genes that share phenotypes with ZDHHC4: view

Animal Model Products

miRNA for ZDHHC4 Gene

miRTarBase miRNAs that target ZDHHC4

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC4 Gene

Localization for ZDHHC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC4 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 4

Gene Ontology (GO) - Cellular Components for ZDHHC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IDA 16647879
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC4: view

Pathways & Interactions for ZDHHC4 Gene

SuperPathways for ZDHHC4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC4 Gene

Drugs & Compounds for ZDHHC4 Gene

(1) Drugs for ZDHHC4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for ZDHHC4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
genes like me logo Genes that share compounds with ZDHHC4: view

Transcripts for ZDHHC4 Gene

Unigene Clusters for ZDHHC4 Gene

Zinc finger, DHHC-type containing 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - - - -
SP8: - - - - - -
SP9: - -
SP10: - - - - -

Relevant External Links for ZDHHC4 Gene

GeneLoc Exon Structure for
ZDHHC4
ECgene alternative splicing isoforms for
ZDHHC4

Expression for ZDHHC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZDHHC4 Gene

Protein differential expression in normal tissues from HIPED for ZDHHC4 Gene

This gene is overexpressed in Ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZDHHC4 Gene



Protein tissue co-expression partners for ZDHHC4 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZDHHC4 Gene:

ZDHHC4

SOURCE GeneReport for Unigene cluster for ZDHHC4 Gene:

Hs.5268
genes like me logo Genes that share expression patterns with ZDHHC4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZDHHC4 Gene

Orthologs for ZDHHC4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC4 34 35
  • 99.03 (n)
cow
(Bos Taurus)
Mammalia ZDHHC4 34 35
  • 84.16 (n)
dog
(Canis familiaris)
Mammalia ZDHHC4 34 35
  • 83.19 (n)
mouse
(Mus musculus)
Mammalia Zdhhc4 34 16 35
  • 79.01 (n)
rat
(Rattus norvegicus)
Mammalia Zdhhc4 34
  • 78.43 (n)
oppossum
(Monodelphis domestica)
Mammalia ZDHHC4 35
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC4 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZDHHC4 34 35
  • 61.11 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc4 34
  • 58.2 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18776 34
zebrafish
(Danio rerio)
Actinopterygii zdhhc4 34 35
  • 53.02 (n)
wufa97b04 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5703 34
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERF2 35
  • 19 (a)
OneToMany
Species where no ortholog for ZDHHC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZDHHC4 Gene

ENSEMBL:
Gene Tree for ZDHHC4 (if available)
TreeFam:
Gene Tree for ZDHHC4 (if available)

Paralogs for ZDHHC4 Gene

Paralogs for ZDHHC4 Gene

Pseudogenes.org Pseudogenes for ZDHHC4 Gene

genes like me logo Genes that share paralogs with ZDHHC4: view

Variants for ZDHHC4 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_036260 A breast cancer sample
rs10230366 -- 6,587,929(+) tgcac(A/G)atctc intron-variant, upstream-variant-2KB
rs10235760 -- 6,583,922(+) AAAAG(A/T)TGTAG intron-variant
rs10236658 -- 6,584,655(+) ttgag(A/G)taggg intron-variant
rs10254753 -- 6,578,131(+) GGCCT(A/C)TTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC4 Gene

Variant ID Type Subtype PubMed ID
nsv830895 CNV loss 17160897
nsv7392 OTHER inversion 18451855
nsv606003 CNV loss 21841781
nsv515978 CNV loss 19592680
nsv508444 CNV deletion 20534489
nsv436904 CNV insertion 17901297
nsv1020236 CNV gain 25217958
esv2123966 CNV deletion 18987734
esv1914954 OTHER inversion 16254605
dgv11172n54 CNV loss 21841781
dgv1090n67 CNV gain 20364138

Variation tolerance for ZDHHC4 Gene

Residual Variation Intolerance Score: 66.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.81; 58.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZDHHC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZDHHC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC4 Gene

Disorders for ZDHHC4 Gene

Relevant External Links for ZDHHC4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZDHHC4

No disorders were found for ZDHHC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC4 Gene

Publications for ZDHHC4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64

Products for ZDHHC4 Gene

Sources for ZDHHC4 Gene

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