ZDHHC4 Gene
protein-coding GIFtS: 47
GCID: GC07P006583
|
|
zinc finger, DHHC-type containing 4
| |
Aliases for ZDHHC4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Zinc Finger, DHHC-Type Containing 41 2 | | FLJ104791 | | ZNF3741 2 3 | | Probable Palmitoyltransferase ZDHHC42 | | Zinc Finger DHHC Domain-Containing Protein 42 3 | | Zinc Finger, DHHC Domain Containing 42 | | Zinc Finger Protein 3742 3 | | EC 2.3.1.-3 | | DHHC-42 3 | | EC 2.3.18 |
Export aliases for ZDHHC4 gene to outside databasesPrevious GC identifers: GC07P006261 GC07P006361 GC07P006362 GC07P006390 |
Summaries for ZDHHC4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Gene Wiki entry for ZDHHC4
|
Genomic Views for ZDHHC4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ZDHHC4 gene promoter: C/EBPalpha AREB6 POU2F1 HFH-1 POU2F1a FOXJ2 (long isoform) FOXO4 FOXO1a FOXJ2 FOXO1 Other transcription factors
Search SABiosciences Chromatin IP Primers for ZDHHC4
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZDHHC4 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p22.1 Ensembl cytogenetic band: 7p22.1 HGNC cytogenetic band: 7p22.1ZDHHC4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P006583: view genomic region
(about GC identifiers)
Start:
|
6,617,065 bp from pter |
End:
|
6,629,005 bp from pter |
Size:
|
11,941 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 6,663,507-6,675,503 |
|
Proteins for ZDHHC4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: ZDHC4_HUMAN, Q9NPG8 (See
protein sequence)Recommended Name: Probable palmitoyltransferase ZDHHC4 Size: 344 amino acids; 39787 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: A4D2N9 Q53EV7 Q6FIB5 Q9H0R9Explore the universe of human proteins at neXtProt for ZDHHC4: NX_Q9NPG8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NPG8 2 DME Specific Peptides for ZDHHC4 (Q9NPG8)
ZDHHC4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001127859.1 NP_001127860.1 NP_001127861.1 NP_060576.1 ENSEMBL proteins: ENSP00000385027 ENSP00000337475 ENSP00000379937 ENSP00000418496 ENSP00000379934 ENSP00000379941 ENSP00000379935 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
ZDHHC4 for ontologies About GeneDecksing
ZDHHC4 Antibody Products: Assay Products for ZDHHC4: |
Protein
Domains / Families for ZDHHC4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZDHHC4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NPG8ProtoNet protein and cluster: Q9NPG8 1 Blocks protein family: IPB001594 Zn-finger
UniProtKB/Swiss-Prot: ZDHC4_HUMAN, Q9NPG8Domain: The DHHC domain is required for palmitoyltransferase activity (By similarity)Similarity: Belongs to the DHHC palmitoyltransferase familySimilarity: Contains 1 DHHC-type zinc finger |
Function for ZDHHC4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: ZDHC4_HUMAN, Q9NPG8Catalytic activity: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoAEnzyme Numbers (IUBMB): EC 2.3.12 EC 2.3.1.-1
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC4 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC4 (see all 5) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): ZDHHC4 (NM_018106) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZDHHC4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZDHHC4  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC4 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- | | GO:0016746 | transferase activity, transferring acyl groups |
IEA | -- |
ZDHHC4 for ontologies About GeneDecksing
|
Pathways & Interactions for ZDHHC4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZDHHC4
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
 1 Interacting protein for ZDHHC4 (Q9NPG82, 3 ENSP000003374754) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds for ZDHHC4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for ZDHHC4 Search CenterWatch for drugs/clinical trials and news about ZDHHC4 / ZDHC4 
|
Transcripts for ZDHHC4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for ZDHHC4 gene (4 alternative transcripts): NM_001134387.1 NM_001134388.1 NM_001134389.1 NM_018106.3 Unigene Cluster for ZDHHC4: Zinc finger, DHHC-type containing 4 Hs.5268 [show with all ESTs]Unigene Representative Sequence: AF20193112 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000405731(uc003sqh.3) ENST00000335965 ENST00000493944 ENST00000489138 ENST00000474097 ENST00000396709 ENST00000483589 ENST00000496017 ENST00000396706 ENST00000474738 ENST00000396713(uc003sql.3) ENST00000396707(uc003sqi.3 uc003sqj.3)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC4 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC4 (see all 5) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): ZDHHC4 (NM_018106) | |  | DNA2.0 Custom Codon Optimized Gene
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Additional cDNA sequence: AF201931.1 AK001341.1 AK223532.1 AK308971.1 AL136674.1 AY359090.1 BC001239.1 CR533511.1 12 DOTS entries: DT.92423933 DT.91756385 DT.100820179 DT.99968792 DT.97859761 DT.317580 DT.100820175 DT.95087078 DT.121049016 DT.100820176 DT.121049102 DT.95356009 24/363 AceView cDNA sequences (see all 363): BM667794 BM083439 AA613892 BU615440 CB215726 BM713080 CR611955 CR591069 CR620057 AI083837 CK823414 AI369286 CB125545 AI086913 CB850522 AA077833 AI499022 BM054829 CB150696 BQ182482 CA454040 N94446 AW080718 AA693654 GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC4 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | |
| SP1: | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | - |   | |   | - |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | - |   | |   | - |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | - |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for ZDHHC4
|
Expression for ZDHHC4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZDHHC4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TGGATCCTCG
About this image See ZDHHC4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ZDHHC4
SOURCE GeneReport for Unigene cluster: Hs.5268 SABiosciences Custom PCR Arrays for ZDHHC4
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZDHHC4 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZDHHC4 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZDHHC4 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZDHHC4 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC4 |
Orthologs for ZDHHC4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ZDHHC4 gene from 5/20 species (see all 20) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
ZDHHC41 |
zinc finger, DHHC-type containing 4 |
59.17(n) 50.89(a) |
  |
416561 XM_414861.3 XP_414861.2 |
African clawed frog (Xenopus laevis) |
Amphibia |
Xl.187762 |
Xenopus laevis transcribed sequence with weak similarity more |
73.68(n) |
  |
BI442019.1 |
zebrafish (Danio rerio) |
Actinopterygii |
wufa97b042 |
wufa97b04 |
72.18(n) |
  |
337087 BC053285.1 |
thale cress (Arabidopsis thaliana) |
eudicotyledons |
AT3G049701 |
DHHC-type zinc finger-containing protein |
46.73(n) 36.45(a) |
  |
819657 NM_111369.3 NP_187148.2 |
rice (Oryza sativa) |
Liliopsida |
Os03g03639001 |
hypothetical protein |
43.88(n) 29.45(a) |
  |
4332904 NM_001056704.1 NP_001050169.1 |
ENSEMBL Gene Tree for ZDHHC4 (if available) TreeFam Gene Tree for ZDHHC4 (if available)  |
Paralogs for ZDHHC4 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for ZDHHC4 gene
- ZDHHC12 ZDHHC112 ZDHHC11B2
ZDHHC4 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZDHHC4 PGOHUM00000248576
|
Genomic Variants for ZDHHC4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 7 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for ZDHHC4 (6617065 - 6629005 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for ZDHHC4 1 Inversion: 37290  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZDHHC4 |
|
Disorders
/ Diseases for ZDHHC4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications for ZDHHC4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZDHHC4 gene, integrated from 9 sources (see all 14): (articles sorted by number of sources associating them with ZDHHC4) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- A germline-specific class of small RNAs binds mammali an Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (2006)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its transcriptional activity. (PubMed id 15527767)1 Grimsby S....Souchelnytskyi S. (2004)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
|
External Searches for ZDHHC4 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ZDHHC4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZDHHC4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZDHHC4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for ZDHHC4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZDHHC4 gene: Search GeneIP for patents involving ZDHHC4
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for ZDHHC4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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| |
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| |  |  |  |  | | | | |
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 |
 | | ZDHHC4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC4 |
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| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZDHHC4 |
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