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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZDHHC4 Gene

protein-coding   GIFtS: 46
GCID: GC07P006583

Zinc Finger, DHHC-Type Containing 4

  Search for ZDHHC4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger, DHHC-Type Containing 41 2     Probable Palmitoyltransferase ZDHHC42
Zinc Finger DHHC Domain-Containing Protein 42 3     Zinc Finger, DHHC Domain Containing 42
Zinc Finger Protein 3742 3     EC 2.3.1.-3
DHHC-42 3     EC 2.3.18
ZNF3742 3     

External Ids:    HGNC: 184711   Entrez Gene: 551462   Ensembl: ENSG000001362477   UniProtKB: Q9NPG83   

Export aliases for ZDHHC4 gene to outside databases

Previous GC identifers: GC07P006261 GC07P006361 GC07P006362 GC07P006390


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZDHHC4 Gene: 
ZDHHC4 (zinc finger, DHHC-type containing 4) is a protein-coding gene. GO annotations related to this gene include transferase activity, transferring acyl groups and zinc ion binding. An important paralog of this gene is ZDHHC1.

Gene Wiki entry for ZDHHC4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NC_018918.2  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZDHHC4 gene promoter:
         C/EBPalpha   AREB6   POU2F1   HFH-1   POU2F1a   FOXJ2 (long isoform)   FOXO4   FOXO1a   FOXJ2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZDHHC4 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZDHHC4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZDHHC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.1   Ensembl cytogenetic band:  7p22.1   HGNC cytogenetic band: 7p22.1

ZDHHC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZDHHC4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P006583:  view genomic region     (about GC identifiers)

Start:
6,617,065 bp from pter      End:
6,629,005 bp from pter
Size:
11,941 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 6,663,507-6,675,503     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZDHC4_HUMAN, Q9NPG8 (See protein sequence)
Recommended Name: Probable palmitoyltransferase ZDHHC4  
Size: 344 amino acids; 39787 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: A4D2N9 Q53EV7 Q6FIB5 Q9H0R9

Explore the universe of human proteins at neXtProt for ZDHHC4: NX_Q9NPG8

Explore proteomics data for ZDHHC4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NPG8

  • 2 DME Specific Peptides for ZDHHC4 (Q9NPG8)
     KPARSKH  WVNNCIG 

    ZDHHC4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZDHHC4 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001127859.1  NP_001127860.1  NP_001127861.1  NP_060576.1  

    ENSEMBL proteins: 
     ENSP00000385027   ENSP00000337475   ENSP00000379937   ENSP00000418496   ENSP00000379934  
     ENSP00000379941   ENSP00000379935  

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    Cloud-Clone Corp. Proteins for ZDHHC4 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    ZDHHC4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZDHHC: Zinc fingers, DHHC-type

    1 InterPro protein domain:
     IPR001594 Znf_DHHC_palmitoyltrfase

    Graphical View of Domain Structure for InterPro Entry Q9NPG8

    ProtoNet protein and cluster: Q9NPG8

    1 Blocks protein domain: IPB001594 Zn-finger

    UniProtKB/Swiss-Prot: ZDHC4_HUMAN, Q9NPG8
    Domain: The DHHC domain is required for palmitoyltransferase activity (By similarity)
    Similarity: Belongs to the DHHC palmitoyltransferase family
    Similarity: Contains 1 DHHC-type zinc finger


    ZDHHC4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZDHC4_HUMAN, Q9NPG8
    Catalytic activity: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA

         Enzyme Numbers (IUBMB): EC 2.3.12 EC 2.3.1.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004129cytochrome-c oxidase activity ----
    GO:0008270zinc ion binding IEA--
    GO:0016746transferase activity, transferring acyl groups IEA--
         
    ZDHHC4 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZDHHC4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZDHHC4 (Q9NPG82, 3 ENSP000003374754) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD3P840222, 3, ENSP000003329734MINT-51259 I2D: score=2 STRING: ENSP00000332973
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0055114oxidation-reduction process ----

    ZDHHC4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZDHHC4 (ZDHC4)

    Search CenterWatch for drugs/clinical trials and news about ZDHHC4 / ZDHC4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZDHHC4 gene (4 alternative transcripts): 
    NM_001134387.1  NM_001134388.1  NM_001134389.1  NM_018106.3  

    Unigene Cluster for ZDHHC4:

    Zinc finger, DHHC-type containing 4
    Hs.5268  [show with all ESTs]
    Unigene Representative Sequence: AF201931
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000405731(uc003sqh.3) ENST00000335965 ENST00000493944 ENST00000489138
    ENST00000474097 ENST00000396709 ENST00000483589 ENST00000496017 ENST00000396706
    ENST00000474738 ENST00000396713(uc003sql.3) ENST00000396707(uc003sqi.3 uc003sqj.3)

    miRNA
    Products:
         
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ZDHHC4
    SwitchGear 3'UTR luciferase reporter plasmidZDHHC4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZDHHC4
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    Additional mRNA sequence: 

    AF201931.1 AK001341.1 AK223532.1 AK308971.1 AL136674.1 AY359090.1 BC001239.1 CR533511.1 

    12 DOTS entries:

    DT.92423933  DT.91756385  DT.100820179  DT.99968792  DT.97859761  DT.317580  DT.100820175  DT.95087078 
    DT.121049016  DT.100820176  DT.121049102  DT.95356009 

    24/363 AceView cDNA sequences (see all 363):

    AA603133 CK823414 CB125545 Z45742 AY359090 BM564093 BM083439 BQ016024 
    BQ020032 AA807409 AK001341 BM705739 AA856621 CK299594 AA974359 AA889889 
    AA283047 BE885343 AI369286 CR591069 BU620674 AI018301 BM561654 AI086913 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC4 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10
    SP1:                          -     -     -                 -           -     -                       -                           
    SP2:                          -     -     -     -           -           -     -                       -                           
    SP3:                                            -           -           -     -                       -                           
    SP4:                                                        -           -     -                       -                           
    SP5:                          -                 -           -           -     -                                                   


    ECgene alternative splicing isoforms for ZDHHC4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZDHHC4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGATCCTCG
    ZDHHC4 Expression
    About this image


    See ZDHHC4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZDHHC4

    SOURCE GeneReport for Unigene cluster: Hs.5268
        SABiosciences Custom PCR Arrays for ZDHHC4
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ZDHHC4 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zdhhc41 , 5 zinc finger, DHHC domain containing 41, 5 79.01(n)1
    73.76(a)1
      5 (82.08 cM)5
    728811  NM_028379.51  NP_082655.11 
     1433164895 
    chicken
    (Gallus gallus)
    Aves ZDHHC41 zinc finger, DHHC-type containing 4 59.17(n)
    50.89(a)
      416561  XM_414861.3  XP_414861.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.187762 Xenopus laevis transcribed sequence with weak similarity more 73.68(n)    BI442019.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa97b042 wufa97b04 72.18(n)   337087  BC053285.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SWF16
    Palmitoyltransferase that acts on transmembrane pr...
    17(a)
    1 → many
    IV(703234-704244)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G049701 DHHC-type zinc finger-containing protein 46.73(n)
    36.45(a)
      819657  NM_111369.3  NP_187148.2 
    rice
    (Oryza sativa)
    Liliopsida Os03g03639001 hypothetical protein 43.88(n)
    29.45(a)
      4332904  NM_001056704.1  NP_001050169.1 


    ENSEMBL Gene Tree for ZDHHC4 (if available)
    TreeFam Gene Tree for ZDHHC4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZDHHC4 gene
    ZDHHC12  ZDHHC142  ZDHHC112  ZDHHC52  ZDHHC11B2  ZDHHC82  ZDHHC192  ZDHHC92  
    ZDHHC182  

    ZDHHC4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZDHHC4
    PGOHUM00000248576


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/381 SNPs in ZDHHC4 are shown (see all 381)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362604
    A breast cancer sample4--see VAR_0362602 P S mis40--------
    rs590145601,2
    C--6488391(+) ATAAA-/ATAAAA 4 -- us2k10--------
    rs1387096961,2
    C--6615114(+) CAACAA/CTCCAA 4 -- us2k10--------
    rs1181814041,2
    F--6615141(+) CCATGC/AATCAC 4 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1848594071,2
    --6615192(+) TTAAGC/GTTAAG 4 -- us2k10--------
    rs1171704601,2
    F--6615246(+) GGTTTG/TCGCTT 4 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1887505331,2
    --6615254(+) CTTGGA/CTGTTT 4 -- us2k10--------
    rs715399581,2
    C--6615323(+) TAATC-/T/TTT 
    TTTTTTTT
    TTTTT
    4 -- us2k11NA 2
    rs665201171,2
    C--6615332(+) TTTTT-/TT/TTTTTTTT
    TTTTTTTTTTTTT
    TTTTT
    8 -- us2k1 cds11NA 2
    rs1113129141,2
    C,F--6615421(+) CTGGGG/CTCAAA 4 -- us2k11Minor allele frequency- C:0.50CSA 2

    HapMap Linkage Disequilibrium report for ZDHHC4 (6617065 - 6629005 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for ZDHHC4 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2123966CNV Deletion18987734
    nsv436904CNV Insertion17901297
    dgv7149n71CNV Loss21882294
    nsv830895CNV Loss17160897
    dgv7148n71CNV Loss21882294
    dgv7147n71CNV Loss21882294
    nsv515978CNV Loss19592680
    nsv508444CNV Loss20534489
    dgv1090n67CNV Gain20364138
    esv1914954OTHER Inversion16254605

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for ZDHHC4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZDHHC4 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with ZDHHC4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    6. A germline-specific class of small RNAs binds mammali an Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (2006)
    7. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    8. Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its transcriptional activity. (PubMed id 15527767)1 Grimsby S....Souchelnytskyi S. (2004)
    9. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
    10. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55146 HGNC: 18471 AceView: ZDHHC4andC7orf26 Ensembl:ENSG00000136247 euGenes: HUgn55146
    ECgene: ZDHHC4 H-InvDB: ZDHHC4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZDHHC4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZDHHC4 gene:
    Search GeneIP for patents involving ZDHHC4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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