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Aliases for ZDHHC4 Gene

Aliases for ZDHHC4 Gene

  • Zinc Finger, DHHC-Type Containing 4 2 3
  • Zinc Finger DHHC Domain-Containing Protein 4 3 4
  • Zinc Finger Protein 374 3 4
  • DHHC-4 3 4
  • ZNF374 3 4
  • Zinc Finger, DHHC Domain Containing 4 3
  • Probable Palmitoyltransferase ZDHHC4 3
  • EC 2.3.1.225 4
  • EC 2.3.1 64

External Ids for ZDHHC4 Gene

Summaries for ZDHHC4 Gene

GeneCards Summary for ZDHHC4 Gene

ZDHHC4 (Zinc Finger, DHHC-Type Containing 4) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring acyl groups. An important paralog of this gene is ZDHHC11B.

Gene Wiki entry for ZDHHC4 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC4 Gene

Genomics for ZDHHC4 Gene

Genomic Location for ZDHHC4 Gene

Start:
6,577,434 bp from pter
End:
6,589,374 bp from pter
Size:
11,941 bases
Orientation:
Plus strand

Genomic View for ZDHHC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZDHHC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC4 Gene

Regulatory Elements for ZDHHC4 Gene

Proteins for ZDHHC4 Gene

  • Protein details for ZDHHC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPG8-ZDHC4_HUMAN
    Recommended name:
    Probable palmitoyltransferase ZDHHC4
    Protein Accession:
    Q9NPG8
    Secondary Accessions:
    • A4D2N9
    • Q53EV7
    • Q6FIB5
    • Q9H0R9

    Protein attributes for ZDHHC4 Gene

    Size:
    344 amino acids
    Molecular mass:
    39787 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZDHHC4 Gene

Proteomics data for ZDHHC4 Gene at MOPED

Selected DME Specific Peptides for ZDHHC4 Gene

Post-translational modifications for ZDHHC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for ZDHHC4 Gene

Gene Families for ZDHHC4 Gene

HGNC:
  • ZDHHC :Zinc fingers, DHHC-type

Protein Domains for ZDHHC4 Gene

UniProtKB/Swiss-Prot:

ZDHC4_HUMAN
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.:
    • Q9NPG8
Family:
  • Belongs to the DHHC palmitoyltransferase family.:
    • Q9NPG8
Similarity:
  • Contains 1 DHHC-type zinc finger.:
    • Q9NPG8
genes like me logo Genes that share domains with ZDHHC4: view

Function for ZDHHC4 Gene

Molecular function for ZDHHC4 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA

Enzyme Numbers (IUBMB) for ZDHHC4 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004129 cytochrome-c oxidase activity --
GO:0008270 zinc ion binding IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC4: view

miRNA for ZDHHC4 Gene

miRTarBase miRNAs that target ZDHHC4

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZDHHC4 Gene

Localization for ZDHHC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZDHHC4 Gene COMPARTMENTS Subcellular localization image for ZDHHC4 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for ZDHHC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IDA 16647879
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC4: view

Pathways for ZDHHC4 Gene

SuperPathways for ZDHHC4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0055114 oxidation-reduction process --
genes like me logo Genes that share ontologies with ZDHHC4: view

No data available for Pathways by source for ZDHHC4 Gene

Transcripts for ZDHHC4 Gene

Unigene Clusters for ZDHHC4 Gene

Zinc finger, DHHC-type containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - - - -
SP8: - - - - - -
SP9: - -
SP10: - - - - -

Relevant External Links for ZDHHC4 Gene

GeneLoc Exon Structure for
ZDHHC4
ECgene alternative splicing isoforms for
ZDHHC4

Expression for ZDHHC4 Gene

mRNA expression in normal human tissues for ZDHHC4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZDHHC4 Gene

SOURCE GeneReport for Unigene cluster for ZDHHC4 Gene Hs.5268

genes like me logo Genes that share expressions with ZDHHC4: view

Orthologs for ZDHHC4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC4 36
  • 99.03 (n)
  • 98.26 (a)
ZDHHC4 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZDHHC4 36
  • 84.16 (n)
  • 79.59 (a)
ZDHHC4 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZDHHC4 36
  • 83.19 (n)
  • 77.26 (a)
ZDHHC4 37
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zdhhc4 36
  • 79.01 (n)
  • 73.76 (a)
Zdhhc4 16
Zdhhc4 37
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZDHHC4 37
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC4 37
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zdhhc4 36
  • 78.43 (n)
  • 71.14 (a)
chicken
(Gallus gallus)
Aves ZDHHC4 36
  • 61.11 (n)
  • 53.49 (a)
ZDHHC4 37
  • 50 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.18776 36
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc4 36
  • 58.2 (n)
  • 49.23 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5703 36
zebrafish
(Danio rerio)
Actinopterygii wufa97b04 36
zdhhc4 36
  • 53.02 (n)
  • 45.32 (a)
zdhhc4 37
  • 45 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERF2 37
  • 19 (a)
OneToMany
Species with no ortholog for ZDHHC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZDHHC4 Gene

ENSEMBL:
Gene Tree for ZDHHC4 (if available)
TreeFam:
Gene Tree for ZDHHC4 (if available)

Paralogs for ZDHHC4 Gene

Pseudogenes.org Pseudogenes for ZDHHC4 Gene

genes like me logo Genes that share paralogs with ZDHHC4: view

Variants for ZDHHC4 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1880119 -- 6,575,809(-) AGCTG(A/T)GGTGG upstream-variant-2KB
rs3813516 -- 6,576,283(-) ACATA(A/C/G/T)CCCTG upstream-variant-2KB
rs4075107 -- 6,582,506(-) CATAC(C/G)GATCA intron-variant
rs4304249 -- 6,584,569(+) tgaat(A/T)caaag intron-variant
rs4336516 -- 6,585,460(+) AACTG(A/C)TGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC4 Gene

Variant ID Type Subtype PubMed ID
nsv436904 CNV Insertion 17901297
nsv7392 OTHER Inversion 18451855
esv1914954 OTHER Inversion 16254605
nsv830895 CNV Loss 17160897
dgv7147n71 CNV Loss 21882294
nsv508444 CNV Loss 20534489
nsv515978 CNV Loss 19592680
dgv7148n71 CNV Loss 21882294
dgv7149n71 CNV Loss 21882294
esv2123966 CNV Deletion 18987734
dgv1090n67 CNV Gain 20364138

Relevant External Links for ZDHHC4 Gene

HapMap Linkage Disequilibrium report
ZDHHC4

Disorders for ZDHHC4 Gene

No disorders were found for ZDHHC4 Gene.

No data available for UniProtKB/Swiss-Prot for ZDHHC4 Gene

Publications for ZDHHC4 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ZDHHC4 Gene

Sources for ZDHHC4 Gene

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