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ZDHHC4 Gene

protein-coding   GIFtS: 48
GCID: GC07P006583

Zinc Finger, DHHC-Type Containing 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, DHHC-Type Containing 41 2     Probable Palmitoyltransferase ZDHHC42
Zinc Finger DHHC Domain-Containing Protein 42 3     Zinc Finger, DHHC Domain Containing 42
Zinc Finger Protein 3742 3     EC 2.3.1.2253
DHHC-42 3     EC 2.3.18
ZNF3742 3     

External Ids:    HGNC: 184711   Entrez Gene: 551462   Ensembl: ENSG000001362477   UniProtKB: Q9NPG83   

Export aliases for ZDHHC4 gene to outside databases

Previous GC identifers: GC07P006261 GC07P006361 GC07P006362 GC07P006390


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZDHHC4 Gene:
ZDHHC4 (zinc finger, DHHC-type containing 4) is a protein-coding gene. GO annotations related to this gene include transferase activity, transferring acyl groups. An important paralog of this gene is ZDHHC1.

Gene Wiki entry for ZDHHC4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZDHHC4 gene promoter:
         C/EBPalpha   AREB6   POU2F1   HFH-1   POU2F1a   FOXJ2 (long isoform)   FOXO4   FOXO1a   FOXJ2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZDHHC4 promoter sequence
   Search Chromatin IP Primers for ZDHHC4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZDHHC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.1   Ensembl cytogenetic band:  7p22.1   HGNC cytogenetic band: 7p22.1

ZDHHC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZDHHC4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P006583:  view genomic region     (about GC identifiers)

Start:
6,617,065 bp from pter      End:
6,629,005 bp from pter
Size:
11,941 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 6,663,507-6,675,503     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZDHC4_HUMAN, Q9NPG8 (See protein sequence)
Recommended Name: Probable palmitoyltransferase ZDHHC4  
Size: 344 amino acids; 39787 Da
Secondary accessions: A4D2N9 Q53EV7 Q6FIB5 Q9H0R9

Explore the universe of human proteins at neXtProt for ZDHHC4: NX_Q9NPG8

Explore proteomics data for ZDHHC4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for ZDHHC4 (Q9NPG8)
     KPARSKH  WVNNCIG 


    See ZDHHC4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001127859.1  NP_001127860.1  NP_001127861.1  NP_060576.1  

    ENSEMBL proteins: 
     ENSP00000385027   ENSP00000337475   ENSP00000379937   ENSP00000418496   ENSP00000379934  
     ENSP00000379941   ENSP00000379935  

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    antibodies-online peptides for ZDHHC4

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    antibodies-online kits for ZDHHC4 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZDHHC: Zinc fingers, DHHC-type

    1 InterPro protein domain:
     IPR001594 Znf_DHHC_palmitoyltrfase

    Graphical View of Domain Structure for InterPro Entry Q9NPG8

    ProtoNet protein and cluster: Q9NPG8

    1 Blocks protein domain: IPB001594 Zn-finger

    UniProtKB/Swiss-Prot: ZDHC4_HUMAN, Q9NPG8
    Domain: The DHHC domain is required for palmitoyltransferase activity (By similarity)
    Similarity: Belongs to the DHHC palmitoyltransferase family
    Similarity: Contains 1 DHHC-type zinc finger


    Find genes that share domains with ZDHHC4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZDHC4_HUMAN, Q9NPG8
    Catalytic activity: Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA

         Enzyme Numbers (IUBMB): EC 2.3.1.2251 EC 2.3.12

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004129cytochrome-c oxidase activity ----
    GO:0008270zinc ion binding IEA--
    GO:0019706protein-cysteine S-palmitoyltransferase activity IEA--
         
    Find genes that share ontologies with ZDHHC4           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZDHHC4

    miRNA
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    miRTarBase miRNAs that target ZDHHC4:
    hsa-mir-1226-3p (MIRT036465), hsa-mir-107 (MIRT026977)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZDHC4_HUMAN, Q9NPG8: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus IDA16647879
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with ZDHHC4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZDHHC4
    Interactions:

        Search GeneGlobe Interaction Network for ZDHHC4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for ZDHHC4 (Q9NPG82, 3 ENSP000003374754) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD3P840222, 3, ENSP000003329734MINT-51259 I2D: score=2 STRING: ENSP00000332973
    COQ2ENSP000004092754STRING: ENSP00000409275
    SCAF4ENSP000002868354STRING: ENSP00000286835
    SCAF8ENSP000003561464STRING: ENSP00000356146
    CDC42ENSP000003144584STRING: ENSP00000314458
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0055114oxidation-reduction process ----

    Find genes that share ontologies with ZDHHC4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZDHHC4 (ZDHC4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZDHHC4 gene (4 alternative transcripts): 
    NM_001134387.1  NM_001134388.1  NM_001134389.1  NM_018106.3  

    Unigene Cluster for ZDHHC4:

    Zinc finger, DHHC-type containing 4
    Hs.5268  [show with all ESTs]
    Unigene Representative Sequence: AF201931
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000405731(uc003sqh.3) ENST00000335965 ENST00000493944 ENST00000489138
    ENST00000474097 ENST00000396709 ENST00000483589 ENST00000496017 ENST00000396706
    ENST00000474738 ENST00000396713(uc003sql.3) ENST00000396707(uc003sqi.3 uc003sqj.3)

    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ZDHHC4
      QuantiFast Probe-based Assays in human, mouse, rat ZDHHC4

    Additional mRNA sequence: 

    AF201931.1 AK001341.1 AK223532.1 AK308971.1 AL136674.1 AY359090.1 BC001239.1 CR533511.1 

    12 DOTS entries:

    DT.92423933  DT.91756385  DT.100820179  DT.99968792  DT.97859761  DT.317580  DT.100820175  DT.95087078 
    DT.121049016  DT.100820176  DT.121049102  DT.95356009 

    Selected AceView cDNA sequences (see all 363):

    AA077833 AA693654 CK823414 AA077654 CR611955 CD674200 CA454040 CA446796 
    BQ020032 BQ182482 BM083439 CR616747 AI086913 AA603133 CB150696 BU620674 
    AI499022 CB215726 BM893816 BM713080 AI146852 CR620057 BE885343 CR591069 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC4 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10
    SP1:                          -     -     -                 -           -     -                       -                           
    SP2:                          -     -     -     -           -           -     -                       -                           
    SP3:                                            -           -           -     -                       -                           
    SP4:                                                        -           -     -                       -                           
    SP5:                          -                 -           -           -     -                                                   


    ECgene alternative splicing isoforms for ZDHHC4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZDHHC4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGATCCTCG
    ZDHHC4 Expression
    About this image

    ZDHHC4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZDHHC4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.5268
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ZDHHC4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zdhhc41 , 5 zinc finger, DHHC domain containing 41, 5 79.01(n)1
    73.76(a)1
      5 (82.08 cM)5
    728811  NM_028379.51  NP_082655.11 
     1433164895 
    chicken
    (Gallus gallus)
    Aves ZDHHC41 zinc finger, DHHC-type containing 4 61.11(n)
    53.49(a)
      416561  XM_414861.4  XP_414861.3 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.187762 Xenopus laevis transcribed sequence with weak similarity more 73.68(n)    BI442019.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa97b042 wufa97b04 72.18(n)   337087  BC053285.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ERF26
    Subunit of a palmitoyltransferase, composed of Erf...
    19(a)
    1 → many
    XII(627118-628197) YLR246W


    ENSEMBL Gene Tree for ZDHHC4 (if available)
    TreeFam Gene Tree for ZDHHC4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZDHHC4 gene
    ZDHHC12  ZDHHC142  ZDHHC112  ZDHHC52  ZDHHC11B2  ZDHHC82  ZDHHC192  ZDHHC92  
    ZDHHC182  

    Find genes that share paralogs with ZDHHC4           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZDHHC4
    PGOHUM00000248576


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZDHHC4 (see all 381)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362604
    A breast cancer sample4--see VAR_0362602 P S mis40--------
    rs590145601,2
    C--6488391(+) ATAAA-/ATAAAA 4 -- us2k10--------
    rs1387096961,2
    C--6615114(+) CAACAA/CTCCAA 4 -- us2k10--------
    rs1181814041,2
    F--6615141(+) CCATGC/AATCAC 4 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1848594071,2
    --6615192(+) TTAAGC/GTTAAG 4 -- us2k10--------
    rs1171704601,2
    F--6615246(+) GGTTTG/TCGCTT 4 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1887505331,2
    --6615254(+) CTTGGA/CTGTTT 4 -- us2k10--------
    rs715399581,2
    C--6615323(+) TAATC-/T/TTT 
    TTTTTTTT
    TTTTT
    4 -- us2k11NA 2
    rs665201171,2
    C--6615332(+) TTTTT-/TT/TTTTTTTT
    TTTTTTTTTTTTT
    TTTTT
    8 -- us2k1 cds11NA 2
    rs1113129141,2
    C,F--6615421(+) CTGGGG/CTCAAA 4 -- us2k11Minor allele frequency- C:0.50CSA 2

    HapMap Linkage Disequilibrium report for ZDHHC4 (6617065 - 6629005 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZDHHC4 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2123966CNV Deletion18987734
    nsv436904CNV Insertion17901297
    dgv7149n71CNV Loss21882294
    nsv830895CNV Loss17160897
    dgv7148n71CNV Loss21882294
    dgv7147n71CNV Loss21882294
    nsv515978CNV Loss19592680
    nsv508444CNV Loss20534489
    dgv1090n67CNV Gain20364138
    esv1914954OTHER Inversion16254605

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZDHHC4 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with ZDHHC4)
        Utopia: connect your pdf to the dynamic
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    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    6. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (Nature 2006)
    7. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    8. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. (PubMed id 16647879)1 Ohno Y....Igarashi Y. (Biochim. Biophys. Acta 2006)
    9. Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its transcriptional activity. (PubMed id 15527767)1 Grimsby S....Souchelnytskyi S. (FEBS Lett. 2004)
    10. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55146 HGNC: 18471 AceView: ZDHHC4andC7orf26 Ensembl:ENSG00000136247 euGenes: HUgn55146
    ECgene: ZDHHC4 H-InvDB: ZDHHC4

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZDHHC4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZDHHC4 gene:
    Search GeneIP for patents involving ZDHHC4

    GeneCards and IP:
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