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Aliases for ZDHHC3 Gene

Aliases for ZDHHC3 Gene

  • Zinc Finger DHHC-Type Containing 3 2 3
  • Zinc Finger DHHC Domain-Containing Protein 3 3 4
  • Golgi-Specific DHHC Zinc Finger Protein 2 3
  • Zinc Finger, DHHC-Type Containing 3 3 5
  • DHHC-3 3 4
  • Golgi Apparatus-Specific Protein With DHHC Zinc Finger Domain 3
  • Zinc Finger, DHHC Domain Containing 3 3
  • Zinc Finger Protein 373 3
  • DHHC1 Protein 3
  • Protein DHHC1 4
  • EC 2.3.1.225 4
  • EC 2.3.1 63
  • ZNF373 3
  • GODZ 3

External Ids for ZDHHC3 Gene

Previous GeneCards Identifiers for ZDHHC3 Gene

  • GC03M043924
  • GC03M044146
  • GC03M044785
  • GC03M044927
  • GC03M044941

Summaries for ZDHHC3 Gene

GeneCards Summary for ZDHHC3 Gene

ZDHHC3 (Zinc Finger DHHC-Type Containing 3) is a Protein Coding gene. GO annotations related to this gene include protein-cysteine S-palmitoyltransferase activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC7.

UniProtKB/Swiss-Prot for ZDHHC3 Gene

  • Palmitoyltransferase with broad specificity. Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability. Palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi. May also palmitoylate DLG4, DNAJC5 and SNAP25.

Gene Wiki entry for ZDHHC3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC3 Gene

Genomics for ZDHHC3 Gene

Regulatory Elements for ZDHHC3 Gene

Enhancers for ZDHHC3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZDHHC3 on UCSC Golden Path with GeneCards custom track

Promoters for ZDHHC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZDHHC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZDHHC3 Gene

Chromosome:
3
Start:
44,915,257 bp from pter
End:
44,976,185 bp from pter
Size:
60,929 bases
Orientation:
Minus strand

Genomic View for ZDHHC3 Gene

Genes around ZDHHC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC3 Gene

Proteins for ZDHHC3 Gene

  • Protein details for ZDHHC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYG2-ZDHC3_HUMAN
    Recommended name:
    Palmitoyltransferase ZDHHC3
    Protein Accession:
    Q9NYG2
    Secondary Accessions:
    • Q53A17
    • Q96BL0

    Protein attributes for ZDHHC3 Gene

    Size:
    299 amino acids
    Molecular mass:
    34170 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZDHHC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZDHHC3 Gene

Proteomics data for ZDHHC3 Gene at MOPED

Selected DME Specific Peptides for ZDHHC3 Gene

Post-translational modifications for ZDHHC3 Gene

Domains & Families for ZDHHC3 Gene

Gene Families for ZDHHC3 Gene

Protein Domains for ZDHHC3 Gene

Suggested Antigen Peptide Sequences for ZDHHC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYG2

UniProtKB/Swiss-Prot:

ZDHC3_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
  • Contains 1 DHHC-type zinc finger.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family.
Similarity:
  • Contains 1 DHHC-type zinc finger.
genes like me logo Genes that share domains with ZDHHC3: view

Function for ZDHHC3 Gene

Molecular function for ZDHHC3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
UniProtKB/Swiss-Prot Function:
Palmitoyltransferase with broad specificity. Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability. Palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi. May also palmitoylate DLG4, DNAJC5 and SNAP25.

Enzyme Numbers (IUBMB) for ZDHHC3 Gene

genes like me logo Genes that share phenotypes with ZDHHC3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ZDHHC3

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC3 Gene

Localization for ZDHHC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC3 Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZDHHC3 Gene COMPARTMENTS Subcellular localization image for ZDHHC3 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
endosome 1

No data available for Gene Ontology (GO) - Cellular Components for ZDHHC3 Gene

Pathways & Interactions for ZDHHC3 Gene

SuperPathways for ZDHHC3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC3 Gene

Drugs & Compounds for ZDHHC3 Gene

(1) Drugs for ZDHHC3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for ZDHHC3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
genes like me logo Genes that share compounds with ZDHHC3: view

Transcripts for ZDHHC3 Gene

Unigene Clusters for ZDHHC3 Gene

Zinc finger, DHHC-type containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - -
SP2: - -
SP3: - - -
SP4: -
SP5: - -
SP6:
SP7:

Relevant External Links for ZDHHC3 Gene

GeneLoc Exon Structure for
ZDHHC3
ECgene alternative splicing isoforms for
ZDHHC3

Expression for ZDHHC3 Gene

mRNA expression in normal human tissues for ZDHHC3 Gene

Protein differential expression in normal tissues from HIPED for ZDHHC3 Gene

This gene is overexpressed in Nasal epithelium (66.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZDHHC3 Gene



SOURCE GeneReport for Unigene cluster for ZDHHC3 Gene Hs.61430

genes like me logo Genes that share expression patterns with ZDHHC3: view

Protein tissue co-expression partners for ZDHHC3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZDHHC3 Gene

Orthologs for ZDHHC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZDHHC3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZDHHC3 35
  • 93.65 (n)
  • 97.32 (a)
-- 36
  • 37 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
ZDHHC3 36
  • 97 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ZDHHC3 35
  • 94.98 (n)
  • 99 (a)
ZDHHC3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zdhhc3 35
  • 94.43 (n)
  • 97.32 (a)
Zdhhc3 16
Zdhhc3 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC3 35
  • 99.78 (n)
  • 100 (a)
ZDHHC3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zdhhc3 35
  • 94.31 (n)
  • 98.33 (a)
oppossum
(Monodelphis domestica)
Mammalia ZDHHC3 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC3 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZDHHC3 35
  • 81.61 (n)
  • 90.64 (a)
ZDHHC3 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZDHHC3 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc3 35
  • 79.08 (n)
  • 85.91 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12303 35
zebrafish
(Danio rerio)
Actinopterygii zdhhc3b 35
  • 75.03 (n)
  • 82.37 (a)
zdhhc3a 36
  • 69 (a)
OneToMany
zdhhc3b 36
  • 81 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8314 37
  • 57 (a)
CG8314 35
  • 62.95 (n)
  • 63.75 (a)
CG8314 36
  • 56 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003613 35
  • 63.75 (n)
  • 62.36 (a)
worm
(Caenorhabditis elegans)
Secernentea C17D12.1a 37
  • 34 (a)
F33D11.12 37
  • 50 (a)
F33D11.12 35
  • 57.4 (n)
  • 58.09 (a)
dhhc-3 36
  • 54 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11968 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 61 (a)
OneToMany
Species with no ortholog for ZDHHC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC3 Gene

ENSEMBL:
Gene Tree for ZDHHC3 (if available)
TreeFam:
Gene Tree for ZDHHC3 (if available)

Paralogs for ZDHHC3 Gene

Paralogs for ZDHHC3 Gene

(6) SIMAP similar genes for ZDHHC3 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for ZDHHC3 Gene

genes like me logo Genes that share paralogs with ZDHHC3: view

Variants for ZDHHC3 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs6622 -- 44,915,368(+) TCAGT(C/T)TGAGG nc-transcript-variant, utr-variant-3-prime
rs15205 -- 44,925,414(+) CAATA(A/T)TCATA intron-variant, utr-variant-3-prime
rs2279909 -- 44,924,758(-) GCTCA(C/G)TTAGG intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1979946 -- 44,922,993(-) CTAAT(C/G)GGTTT intron-variant, utr-variant-3-prime
rs2372849 -- 44,922,475(+) TGTCT(C/T)GGCAG intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC3 Gene

Variant ID Type Subtype PubMed ID
nsv834675 CNV Gain 17160897
nsv834676 CNV Gain+Loss 17160897

Variation tolerance for ZDHHC3 Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZDHHC3 Gene

HapMap Linkage Disequilibrium report
ZDHHC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC3 Gene

Disorders for ZDHHC3 Gene

Relevant External Links for ZDHHC3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZDHHC3

No disorders were found for ZDHHC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC3 Gene

Publications for ZDHHC3 Gene

  1. Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system. (PMID: 23034182) Ohno Y. … Kihara A. (Mol. Biol. Cell 2012) 3 4 67
  2. Golgi-specific DHHC zinc finger protein GODZ mediates membrane Ca2+ transport. (PMID: 19955568) Hines R.M. … Quamme G.A. (J. Biol. Chem. 2010) 2 3
  3. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3
  4. In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes. (PMID: 23687301) Oku S. … Fukata M. (J. Biol. Chem. 2013) 3
  5. Palmitoylation by DHHC3 is critical for the function, expression, and stability of integrin I+6I^4. (PMID: 22314500) Sharma C. … Hemler M.E. (Cell. Mol. Life Sci. 2012) 3

Products for ZDHHC3 Gene

Sources for ZDHHC3 Gene

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