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Aliases for ZDHHC3 Gene

Aliases for ZDHHC3 Gene

  • Zinc Finger DHHC-Type Containing 3 2 3 5
  • Zinc Finger DHHC Domain-Containing Protein 3 3 4
  • Golgi-Specific DHHC Zinc Finger Protein 2 3
  • DHHC-3 3 4
  • Golgi Apparatus-Specific Protein With DHHC Zinc Finger Domain 3
  • Zinc Finger, DHHC Domain Containing 3 3
  • Palmitoyltransferase ZDHHC3 3
  • Zinc Finger Protein 373 3
  • DHHC1 Protein 3
  • Protein DHHC1 4
  • EC 2.3.1.225 4
  • EC 2.3.1 61
  • ZNF373 3
  • DHHC3 3
  • GODZ 3

External Ids for ZDHHC3 Gene

Previous GeneCards Identifiers for ZDHHC3 Gene

  • GC03M043924
  • GC03M044146
  • GC03M044785
  • GC03M044927
  • GC03M044941

Summaries for ZDHHC3 Gene

GeneCards Summary for ZDHHC3 Gene

ZDHHC3 (Zinc Finger DHHC-Type Containing 3) is a Protein Coding gene. GO annotations related to this gene include protein-cysteine S-palmitoyltransferase activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC7.

UniProtKB/Swiss-Prot for ZDHHC3 Gene

  • Palmitoyltransferase with broad specificity. Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability. Palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi. May also palmitoylate DLG4, DNAJC5 and SNAP25.

Gene Wiki entry for ZDHHC3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC3 Gene

Genomics for ZDHHC3 Gene

Regulatory Elements for ZDHHC3 Gene

Enhancers for ZDHHC3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F045687 1.4 Ensembl ENCODE 20 -715.7 -715735 8.1 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SACM1L XCR1 RN7SL145P LIMD1 ZDHHC3 EXOSC7 LARS2-AS1 CCR9 SDHDP4 LIMD1-AS1
GH03F044992 1.6 FANTOM5 Ensembl ENCODE 12 -18.5 -18530 5.3 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 ZNF143 EXOSC7 ZDHHC3 RN7SL145P RNU5B-3P ZNF35 CLEC3B LIMD1 ENSG00000202268 ZNF502 ZNF660
GH03F045638 1.8 FANTOM5 Ensembl ENCODE 10 -667.4 -667426 9.6 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 MEF2D LIMD1 SACM1L XCR1 RPS24P8 ZNF501 RN7SL145P LARS2-AS1 LIMD1-AS1 EXOSC7 ZDHHC3
GH03F045052 1.7 FANTOM5 Ensembl ENCODE 10.1 -83.8 -83759 14.5 HDGF PKNOX1 ARNT CREB3L1 YY1 ZNF766 FOS KLF13 REST TBX21 EXOSC7 LIMD1 CLEC3B CDCP1 XCR1 ZNF660 SACM1L RN7SL145P RNU5B-3P TMEM158
GH03F045507 1.3 Ensembl ENCODE 11.7 -532.9 -532889 3.4 HDGF ATF1 PKNOX1 SIN3A ZNF2 YY1 ZNF121 GLIS2 FOS KDM4B LARS2 LIMD1 ZDHHC3 RN7SL145P XCR1 ZNF35 LARS2-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZDHHC3 on UCSC Golden Path with GeneCards custom track

Promoters for ZDHHC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001478702 -15 2401 ATF1 CREB3L1 WRNIP1 ZNF133 ARID4B SIN3A DMAP1 ZNF48 BRCA1 ZNF2

Genomic Location for ZDHHC3 Gene

Chromosome:
3
Start:
44,915,257 bp from pter
End:
44,976,185 bp from pter
Size:
60,929 bases
Orientation:
Minus strand

Genomic View for ZDHHC3 Gene

Genes around ZDHHC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC3 Gene

Proteins for ZDHHC3 Gene

  • Protein details for ZDHHC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYG2-ZDHC3_HUMAN
    Recommended name:
    Palmitoyltransferase ZDHHC3
    Protein Accession:
    Q9NYG2
    Secondary Accessions:
    • Q53A17
    • Q96BL0

    Protein attributes for ZDHHC3 Gene

    Size:
    299 amino acids
    Molecular mass:
    34170 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZDHHC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZDHHC3 Gene

Selected DME Specific Peptides for ZDHHC3 Gene

Q9NYG2:
  • KPDRAHH
  • MDHHCPW
  • WFIRDGCG
  • MLTDPGAVPKGNATKE
  • FVLFTMYIAL

Post-translational modifications for ZDHHC3 Gene

Antibody Products

  • Abcam antibodies for ZDHHC3

Domains & Families for ZDHHC3 Gene

Gene Families for ZDHHC3 Gene

Protein Domains for ZDHHC3 Gene

Suggested Antigen Peptide Sequences for ZDHHC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYG2

UniProtKB/Swiss-Prot:

ZDHC3_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
  • Contains 1 DHHC domain.
Family:
  • Belongs to the DHHC palmitoyltransferase family.
genes like me logo Genes that share domains with ZDHHC3: view

Function for ZDHHC3 Gene

Molecular function for ZDHHC3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
UniProtKB/Swiss-Prot Function:
Palmitoyltransferase with broad specificity. Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability. Palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi. May also palmitoylate DLG4, DNAJC5 and SNAP25.

Enzyme Numbers (IUBMB) for ZDHHC3 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016409 palmitoyltransferase activity IDA 23034182
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC3: view
genes like me logo Genes that share phenotypes with ZDHHC3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ZDHHC3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC3 Gene

Localization for ZDHHC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC3 Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC3 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
endosome 1

Gene Ontology (GO) - Cellular Components for ZDHHC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IEA,IDA 16647879
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC3: view

Pathways & Interactions for ZDHHC3 Gene

SuperPathways for ZDHHC3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006605 protein targeting IEA --
GO:0018345 protein palmitoylation IDA 23034182
genes like me logo Genes that share ontologies with ZDHHC3: view

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC3 Gene

Drugs & Compounds for ZDHHC3 Gene

(1) Drugs for ZDHHC3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for ZDHHC3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
genes like me logo Genes that share compounds with ZDHHC3: view

Transcripts for ZDHHC3 Gene

Unigene Clusters for ZDHHC3 Gene

Zinc finger, DHHC-type containing 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - -
SP2: - -
SP3: - - -
SP4: -
SP5: - -
SP6:
SP7:

Relevant External Links for ZDHHC3 Gene

GeneLoc Exon Structure for
ZDHHC3
ECgene alternative splicing isoforms for
ZDHHC3

Expression for ZDHHC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZDHHC3 Gene

Protein differential expression in normal tissues from HIPED for ZDHHC3 Gene

This gene is overexpressed in Nasal epithelium (66.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZDHHC3 Gene



Protein tissue co-expression partners for ZDHHC3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZDHHC3 Gene:

ZDHHC3

SOURCE GeneReport for Unigene cluster for ZDHHC3 Gene:

Hs.61430
genes like me logo Genes that share expression patterns with ZDHHC3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZDHHC3 Gene

Orthologs for ZDHHC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZDHHC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC3 34 35
  • 99.78 (n)
dog
(Canis familiaris)
Mammalia ZDHHC3 34 35
  • 94.98 (n)
mouse
(Mus musculus)
Mammalia Zdhhc3 34 16 35
  • 94.43 (n)
rat
(Rattus norvegicus)
Mammalia Zdhhc3 34
  • 94.31 (n)
cow
(Bos Taurus)
Mammalia ZDHHC3 34 35
  • 93.65 (n)
-- 35
  • 80 (a)
OneToMany
-- 35
  • 37 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ZDHHC3 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC3 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZDHHC3 34 35
  • 81.61 (n)
lizard
(Anolis carolinensis)
Reptilia ZDHHC3 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc3 34
  • 79.08 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12303 34
zebrafish
(Danio rerio)
Actinopterygii zdhhc3b 34 35
  • 75.03 (n)
zdhhc3a 35
  • 69 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003613 34
  • 63.75 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8314 36 34 35
  • 62.95 (n)
worm
(Caenorhabditis elegans)
Secernentea F33D11.12 36 34
  • 57.4 (n)
dhhc-3 35
  • 54 (a)
OneToMany
C17D12.1a 36
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 61 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11968 34
Species where no ortholog for ZDHHC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC3 Gene

ENSEMBL:
Gene Tree for ZDHHC3 (if available)
TreeFam:
Gene Tree for ZDHHC3 (if available)

Paralogs for ZDHHC3 Gene

Paralogs for ZDHHC3 Gene

(6) SIMAP similar genes for ZDHHC3 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for ZDHHC3 Gene

genes like me logo Genes that share paralogs with ZDHHC3: view

Variants for ZDHHC3 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs367543249 untested 44,929,430(+) AGGAG(A/C/G)TGCAC intron-variant, reference, missense
rs367543250 untested 44,959,290(+) GTAAC(A/G)ATGGC upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime
rs367543251 untested 44,959,351(+) CAGGG(C/T)AGGGG upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs10514711 -- 44,954,684(+) ACTGA(C/T)CATAA intron-variant
rs10576157 -- 44,918,234(+) GTGGC(-/G)GGGGG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC3 Gene

Variant ID Type Subtype PubMed ID
esv3568717 CNV loss 25503493
esv3568718 CNV loss 25503493
esv3596040 CNV gain 21293372
esv3596041 CNV loss 21293372
nsv834675 CNV gain 17160897
nsv834676 CNV gain+loss 17160897

Variation tolerance for ZDHHC3 Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZDHHC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZDHHC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC3 Gene

Disorders for ZDHHC3 Gene

Relevant External Links for ZDHHC3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZDHHC3

No disorders were found for ZDHHC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC3 Gene

Publications for ZDHHC3 Gene

  1. Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system. (PMID: 23034182) Ohno Y. … Kihara A. (Mol. Biol. Cell 2012) 3 4 64
  2. Golgi-specific DHHC zinc finger protein GODZ mediates membrane Ca2+ transport. (PMID: 19955568) Hines R.M. … Quamme G.A. (J. Biol. Chem. 2010) 2 3 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3 64
  5. In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes. (PMID: 23687301) Oku S. … Fukata M. (J. Biol. Chem. 2013) 3 64

Products for ZDHHC3 Gene

Sources for ZDHHC3 Gene

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