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Aliases for ZDHHC3 Gene

Aliases for ZDHHC3 Gene

  • Zinc Finger DHHC-Type Containing 3 2 3 5
  • Zinc Finger DHHC Domain-Containing Protein 3 3 4
  • Golgi-Specific DHHC Zinc Finger Protein 2 3
  • DHHC-3 3 4
  • Golgi Apparatus-Specific Protein With DHHC Zinc Finger Domain 3
  • Zinc Finger, DHHC Domain Containing 3 3
  • Palmitoyltransferase ZDHHC3 3
  • Zinc Finger Protein 373 3
  • DHHC1 Protein 3
  • Protein DHHC1 4
  • EC 2.3.1.225 4
  • EC 2.3.1 56
  • ZNF373 3
  • DHHC3 3
  • GODZ 3

External Ids for ZDHHC3 Gene

Previous GeneCards Identifiers for ZDHHC3 Gene

  • GC03M043924
  • GC03M044146
  • GC03M044785
  • GC03M044927
  • GC03M044941

Summaries for ZDHHC3 Gene

GeneCards Summary for ZDHHC3 Gene

ZDHHC3 (Zinc Finger DHHC-Type Containing 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein-cysteine S-palmitoyltransferase activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC7.

UniProtKB/Swiss-Prot for ZDHHC3 Gene

  • Palmitoyltransferase with broad specificity (PubMed:21926431, PubMed:23034182). Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability (By similarity). Palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi. May also palmitoylate DLG4, DNAJC5 and SNAP25 (By similarity).

Gene Wiki entry for ZDHHC3 Gene

Additional gene information for ZDHHC3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC3 Gene

Genomics for ZDHHC3 Gene

GeneHancer (GH) Regulatory Elements for ZDHHC3 Gene

Promoters and enhancers for ZDHHC3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I044974 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 554.9 +0.4 362 3.6 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF207 SP3 SP5 ZHX2 EXOSC7 ZDHHC3 ZNF445 RN7SL145P CLEC3B ZNF502 ZKSCAN7 ZNF852 RNU5B-3P KIAA1143
GH03I045687 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 11.8 -715.7 -715711 8.2 ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC SACM1L ZNF502 LIMD1 RN7SL145P RPS24P8 ZNF501 ZDHHC3 LARS2-AS1 CCR9 SDHDP4
GH03I044624 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.1 +350.9 350888 2.2 PKNOX1 ARNT ARID4B SIN3A YY1 POLR2B ZNF766 CBX5 E2F8 ZNF143 ZNF197 ZNF197-AS1 ZNF35 ZNF852 KIAA1143 ZNF660 ZDHHC3 ZNF502 ZNF445 ENSG00000236869
GH03I044509 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.1 +465.5 465486 2.6 HDGF ATF1 ARNT ARID4B SIN3A ZNF2 ZNF48 YY1 TCF12 POLR2B ZNF852 ZNF660 ZNF197 ZNF35 ZDHHC3 ZNF502 EI24P3
GH03I044729 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.1 +246.5 246484 1.4 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF143 LOC105377056 ZNF501 KIAA1143 ZNF852 ZNF35 ZNF502 ZDHHC3 PIR43736
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZDHHC3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZDHHC3 gene promoter:

Genomic Locations for ZDHHC3 Gene

Genomic Locations for ZDHHC3 Gene
chr3:44,915,257-44,976,185
(GRCh38/hg38)
Size:
60,929 bases
Orientation:
Minus strand
chr3:44,956,749-45,017,677
(GRCh37/hg19)

Genomic View for ZDHHC3 Gene

Genes around ZDHHC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC3 Gene

Proteins for ZDHHC3 Gene

  • Protein details for ZDHHC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYG2-ZDHC3_HUMAN
    Recommended name:
    Palmitoyltransferase ZDHHC3
    Protein Accession:
    Q9NYG2
    Secondary Accessions:
    • Q53A17
    • Q96BL0

    Protein attributes for ZDHHC3 Gene

    Size:
    299 amino acids
    Molecular mass:
    34170 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZDHHC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZDHHC3 Gene

Selected DME Specific Peptides for ZDHHC3 Gene

Q9NYG2:
  • KPDRAHH
  • MDHHCPW
  • WFIRDGCG
  • MLTDPGAVPKGNATKE
  • FVLFTMYIAL

Post-translational modifications for ZDHHC3 Gene

Domains & Families for ZDHHC3 Gene

Gene Families for ZDHHC3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ZDHHC3 Gene

Suggested Antigen Peptide Sequences for ZDHHC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYG2

UniProtKB/Swiss-Prot:

ZDHC3_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family.
genes like me logo Genes that share domains with ZDHHC3: view

Function for ZDHHC3 Gene

Molecular function for ZDHHC3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
UniProtKB/Swiss-Prot Function:
Palmitoyltransferase with broad specificity (PubMed:21926431, PubMed:23034182). Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability (By similarity). Palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi. May also palmitoylate DLG4, DNAJC5 and SNAP25 (By similarity).

Enzyme Numbers (IUBMB) for ZDHHC3 Gene

Phenotypes From GWAS Catalog for ZDHHC3 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016409 palmitoyltransferase activity IDA 21926431
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC3: view
genes like me logo Genes that share phenotypes with ZDHHC3: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC3 Gene

Localization for ZDHHC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC3 Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC3 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZDHHC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IDA,IEA 16647879
GO:0016020 membrane HDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC3: view

Pathways & Interactions for ZDHHC3 Gene

SuperPathways for ZDHHC3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006605 protein targeting IEA --
GO:0018345 protein palmitoylation IDA 21926431
genes like me logo Genes that share ontologies with ZDHHC3: view

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC3 Gene

Drugs & Compounds for ZDHHC3 Gene

(1) Drugs for ZDHHC3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0

(1) Additional Compounds for ZDHHC3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
genes like me logo Genes that share compounds with ZDHHC3: view

Transcripts for ZDHHC3 Gene

Unigene Clusters for ZDHHC3 Gene

Zinc finger, DHHC-type containing 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - -
SP2: - -
SP3: - - -
SP4: -
SP5: - -
SP6:
SP7:

Relevant External Links for ZDHHC3 Gene

GeneLoc Exon Structure for
ZDHHC3
ECgene alternative splicing isoforms for
ZDHHC3

Expression for ZDHHC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZDHHC3 Gene

Protein differential expression in normal tissues from HIPED for ZDHHC3 Gene

This gene is overexpressed in Nasal epithelium (66.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZDHHC3 Gene



Protein tissue co-expression partners for ZDHHC3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZDHHC3 Gene:

ZDHHC3

SOURCE GeneReport for Unigene cluster for ZDHHC3 Gene:

Hs.61430

Evidence on tissue expression from TISSUES for ZDHHC3 Gene

  • Intestine(4.4)
  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with ZDHHC3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC3 Gene

Orthologs for ZDHHC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZDHHC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC3 33 34
  • 99.78 (n)
dog
(Canis familiaris)
Mammalia ZDHHC3 33 34
  • 94.98 (n)
mouse
(Mus musculus)
Mammalia Zdhhc3 33 16 34
  • 94.43 (n)
rat
(Rattus norvegicus)
Mammalia Zdhhc3 33
  • 94.31 (n)
cow
(Bos Taurus)
Mammalia ZDHHC3 33 34
  • 93.65 (n)
-- 34
  • 80 (a)
OneToMany
-- 34
  • 37 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ZDHHC3 34
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC3 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZDHHC3 33 34
  • 81.61 (n)
lizard
(Anolis carolinensis)
Reptilia ZDHHC3 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc3 33
  • 79.08 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12303 33
zebrafish
(Danio rerio)
Actinopterygii zdhhc3b 33 34
  • 75.03 (n)
zdhhc3a 34
  • 69 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003613 33
  • 63.75 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8314 35 33 34
  • 62.95 (n)
worm
(Caenorhabditis elegans)
Secernentea F33D11.12 35 33
  • 57.4 (n)
dhhc-3 34
  • 54 (a)
OneToMany
C17D12.1a 35
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 61 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11968 33
Species where no ortholog for ZDHHC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC3 Gene

ENSEMBL:
Gene Tree for ZDHHC3 (if available)
TreeFam:
Gene Tree for ZDHHC3 (if available)

Paralogs for ZDHHC3 Gene

Paralogs for ZDHHC3 Gene

(6) SIMAP similar genes for ZDHHC3 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for ZDHHC3 Gene

genes like me logo Genes that share paralogs with ZDHHC3: view

Variants for ZDHHC3 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC3 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs367543249 not-provided, not provided 44,929,430(-) C/A/G coding_sequence_variant, intron_variant, missense_variant
rs367543250 not-provided, not provided 44,959,290(-) G/A 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, synonymous_variant, upstream_transcript_variant
rs367543251 not-provided, not provided 44,959,351(-) T/C 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, upstream_transcript_variant
rs1000006388 -- 44,920,915(-) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000011678 -- 44,942,487(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC3 Gene

Variant ID Type Subtype PubMed ID
esv3568717 CNV loss 25503493
esv3568718 CNV loss 25503493
esv3596040 CNV gain 21293372
esv3596041 CNV loss 21293372
nsv834675 CNV gain 17160897
nsv834676 CNV gain+loss 17160897

Variation tolerance for ZDHHC3 Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZDHHC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZDHHC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC3 Gene

Disorders for ZDHHC3 Gene

Additional Disease Information for ZDHHC3

No disorders were found for ZDHHC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC3 Gene

Publications for ZDHHC3 Gene

  1. Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system. (PMID: 23034182) Ohno Y … Kihara A (Molecular biology of the cell 2012) 3 4 58
  2. Endoplasmic reticulum localization of DHHC palmitoyltransferases mediated by lysine-based sorting signals. (PMID: 21926431) Gorleku OA … Chamberlain LH (The Journal of biological chemistry 2011) 3 4 58
  3. Golgi-specific DHHC zinc finger protein GODZ mediates membrane Ca2+ transport. (PMID: 19955568) Hines RM … Quamme GA (The Journal of biological chemistry 2010) 2 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Protein Acyltransferase DHHC3 Regulates Breast Tumor Growth, Oxidative Stress, and Senescence. (PMID: 29055014) Sharma C … Hemler ME (Cancer research 2017) 3 58

Products for ZDHHC3 Gene

Sources for ZDHHC3 Gene

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