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Aliases for ZDHHC3 Gene

Aliases for ZDHHC3 Gene

  • Zinc Finger, DHHC-Type Containing 3 2 3
  • Zinc Finger DHHC Domain-Containing Protein 3 3 4
  • Golgi-Specific DHHC Zinc Finger Protein 2 3
  • Zinc Finger Protein 373 3 4
  • DHHC-3 3 4
  • ZNF373 3 4
  • Golgi Apparatus-Specific Protein With DHHC Zinc Finger Domain 3
  • Zinc Finger, DHHC Domain Containing 3 3
  • Palmitoyltransferase ZDHHC3 3
  • DHHC1 Protein 3
  • Protein DHHC1 4
  • EC 2.3.1.225 4
  • EC 2.3.1 63
  • GODZ 3

External Ids for ZDHHC3 Gene

Previous GeneCards Identifiers for ZDHHC3 Gene

  • GC03M043924
  • GC03M044146
  • GC03M044785
  • GC03M044927

Summaries for ZDHHC3 Gene

GeneCards Summary for ZDHHC3 Gene

ZDHHC3 (Zinc Finger, DHHC-Type Containing 3) is a Protein Coding gene. GO annotations related to this gene include palmitoyltransferase activity. An important paralog of this gene is ZDHHC7.

UniProtKB/Swiss-Prot for ZDHHC3 Gene

  • Palmitoyltransferase with broad specificity. Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability. Palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi (By similarity).

Gene Wiki entry for ZDHHC3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC3 Gene

Genomics for ZDHHC3 Gene

Regulatory Elements for ZDHHC3 Gene

Genomic Location for ZDHHC3 Gene

Start:
44,915,257 bp from pter
End:
44,976,185 bp from pter
Size:
60,929 bases
Orientation:
Minus strand

Genomic View for ZDHHC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZDHHC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC3 Gene

Proteins for ZDHHC3 Gene

  • Protein details for ZDHHC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYG2-ZDHC3_HUMAN
    Recommended name:
    Palmitoyltransferase ZDHHC3
    Protein Accession:
    Q9NYG2
    Secondary Accessions:
    • Q53A17
    • Q96BL0

    Protein attributes for ZDHHC3 Gene

    Size:
    299 amino acids
    Molecular mass:
    34170 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZDHHC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZDHHC3 Gene

Proteomics data for ZDHHC3 Gene at MOPED

Selected DME Specific Peptides for ZDHHC3 Gene

Post-translational modifications for ZDHHC3 Gene

Domains for ZDHHC3 Gene

Gene Families for ZDHHC3 Gene

HGNC:
  • ZDHHC :Zinc fingers, DHHC-type

Protein Domains for ZDHHC3 Gene

Suggested Antigen Peptide Sequences for ZDHHC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYG2

UniProtKB/Swiss-Prot:

ZDHC3_HUMAN :
  • Q9NYG2
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family.
Similarity:
  • Contains 1 DHHC-type zinc finger.
genes like me logo Genes that share domains with ZDHHC3: view

Function for ZDHHC3 Gene

Molecular function for ZDHHC3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA
UniProtKB/Swiss-Prot Function: Palmitoyltransferase with broad specificity. Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability. Palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi (By similarity).

Enzyme Numbers (IUBMB) for ZDHHC3 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016409 palmitoyltransferase activity IDA 23034182
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC3: view
genes like me logo Genes that share phenotypes with ZDHHC3: view

miRNA for ZDHHC3 Gene

miRTarBase miRNAs that target ZDHHC3

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ZDHHC3 Gene

Localization for ZDHHC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC3 Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZDHHC3 Gene COMPARTMENTS Subcellular localization image for ZDHHC3 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ZDHHC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IDA 16647879
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC3: view

Pathways for ZDHHC3 Gene

SuperPathways for ZDHHC3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006605 protein targeting IEA --
GO:0008152 metabolic process --
GO:0018345 protein palmitoylation IDA 23034182
genes like me logo Genes that share ontologies with ZDHHC3: view

No data available for Pathways by source for ZDHHC3 Gene

Transcripts for ZDHHC3 Gene

Unigene Clusters for ZDHHC3 Gene

Zinc finger, DHHC-type containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - -
SP2: - -
SP3: - - -
SP4: -
SP5: - -
SP6:
SP7:

Relevant External Links for ZDHHC3 Gene

GeneLoc Exon Structure for
ZDHHC3
ECgene alternative splicing isoforms for
ZDHHC3

Expression for ZDHHC3 Gene

mRNA expression in normal human tissues for ZDHHC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZDHHC3 Gene

SOURCE GeneReport for Unigene cluster for ZDHHC3 Gene Hs.61430

genes like me logo Genes that share expressions with ZDHHC3: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZDHHC3 Gene

Orthologs for ZDHHC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZDHHC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC3 35
  • 99.78 (n)
  • 100 (a)
ZDHHC3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 37 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
ZDHHC3 35
  • 93.65 (n)
  • 97.32 (a)
ZDHHC3 36
  • 97 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ZDHHC3 35
  • 94.98 (n)
  • 99 (a)
ZDHHC3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zdhhc3 35
  • 94.43 (n)
  • 97.32 (a)
Zdhhc3 16
Zdhhc3 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZDHHC3 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC3 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zdhhc3 35
  • 94.31 (n)
  • 98.33 (a)
chicken
(Gallus gallus)
Aves ZDHHC3 35
  • 81.61 (n)
  • 90.64 (a)
ZDHHC3 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZDHHC3 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12303 35
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc3 35
  • 79.08 (n)
  • 85.91 (a)
zebrafish
(Danio rerio)
Actinopterygii zdhhc3a 36
  • 69 (a)
OneToMany
zdhhc3b 35
  • 75.03 (n)
  • 82.37 (a)
zdhhc3b 36
  • 81 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003613 35
  • 63.75 (n)
  • 62.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8314 35
  • 62.95 (n)
  • 63.75 (a)
CG8314 36
  • 56 (a)
OneToMany
CG8314 37
  • 57 (a)
worm
(Caenorhabditis elegans)
Secernentea dhhc-3 36
  • 54 (a)
OneToMany
F33D11.12 35
  • 57.4 (n)
  • 58.09 (a)
F33D11.12 37
  • 50 (a)
C17D12.1a 37
  • 34 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11968 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 61 (a)
OneToMany
Species with no ortholog for ZDHHC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC3 Gene

ENSEMBL:
Gene Tree for ZDHHC3 (if available)
TreeFam:
Gene Tree for ZDHHC3 (if available)

Paralogs for ZDHHC3 Gene

Paralogs for ZDHHC3 Gene

Selected SIMAP similar genes for ZDHHC3 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for ZDHHC3 Gene

genes like me logo Genes that share paralogs with ZDHHC3: view

Variants for ZDHHC3 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs6622 -- 44,915,368(+) TCAGT(C/T)TGAGG utr-variant-3-prime
rs15205 -- 44,925,414(+) CAATA(A/T)TCATA utr-variant-3-prime, intron-variant
rs885270 -- 44,937,773(+) GCACC(C/T)GCCGC intron-variant
rs937832 -- 44,915,198(+) CATAA(G/T)GAAGG downstream-variant-500B
rs1401928 -- 44,960,851(-) GACAT(A/G)TCCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC3 Gene

Variant ID Type Subtype PubMed ID
nsv834675 CNV Gain 17160897
nsv834676 CNV Gain+Loss 17160897

Relevant External Links for ZDHHC3 Gene

HapMap Linkage Disequilibrium report
ZDHHC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC3 Gene

Disorders for ZDHHC3 Gene

No disorders were found for ZDHHC3 Gene.

No data available for UniProtKB/Swiss-Prot for ZDHHC3 Gene

Publications for ZDHHC3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Golgi-specific DHHC zinc finger protein GODZ mediates membrane Ca2+ transport. (PMID: 19955568) Hines R.M. … Quamme G.A. (J. Biol. Chem. 2010) 2 3
  3. Regulation in the targeting of TRAIL receptor 1 to cell surface via GODZ for TRAIL sensitivity in tumor cells. (PMID: 22240897) Oh Y. … Jung Y.K. (Cell Death Differ. 2012) 3
  4. Palmitoylation by DHHC3 is critical for the function, expression, and stability of integrin I+6I^4. (PMID: 22314500) Sharma C. … Hemler M.E. (Cell. Mol. Life Sci. 2012) 3
  5. Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system. (PMID: 23034182) Ohno Y. … Kihara A. (Mol. Biol. Cell 2012) 3

Products for ZDHHC3 Gene

Sources for ZDHHC3 Gene

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