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ZDHHC3 Gene

protein-coding   GIFtS: 52
GCID: GC03M044941

Zinc Finger, DHHC-Type Containing 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, DHHC-Type Containing 31 2     DHHC1 Protein2
Golgi-Specific DHHC Zinc Finger Protein1 2     Golgi Apparatus-Specific Protein With DHHC Zinc Finger Domain2
Zinc Finger DHHC Domain-Containing Protein 32 3     Palmitoyltransferase ZDHHC32
Zinc Finger Protein 3732 3     Zinc Finger, DHHC Domain Containing 32
DHHC-32 3     EC 2.3.1.2253
ZNF3732 3     Protein DHHC13
GODZ2     EC 2.3.18

External Ids:    HGNC: 184701   Entrez Gene: 513042   Ensembl: ENSG000001638127   UniProtKB: Q9NYG23   

Export aliases for ZDHHC3 gene to outside databases

Previous GC identifers: GC03M043924 GC03M044146 GC03M044785 GC03M044927


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZDHHC3 Gene:
ZDHHC3 (zinc finger, DHHC-type containing 3) is a protein-coding gene. GO annotations related to this gene include palmitoyltransferase activity. An important paralog of this gene is ZDHHC21.

UniProtKB/Swiss-Prot: ZDHC3_HUMAN, Q9NYG2
Function: Palmitoyltransferase with broad specificity. Palmitoylates GABA receptors on their gamma subunit
(GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability. Palmitoylates
glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi (By similarity)

Gene Wiki entry for ZDHHC3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZDHHC3 gene promoter:
         AML1a   NF-E2 p45   E47   GATA-1   AREB6   PPAR-gamma1   POU2F1   POU2F1a   PPAR-gamma2   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZDHHC3 promoter sequence
   Search Chromatin IP Primers for ZDHHC3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZDHHC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

ZDHHC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZDHHC3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M044941:  view genomic region     (about GC identifiers)

Start:
44,956,749 bp from pter      End:
45,017,677 bp from pter
Size:
60,929 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZDHC3_HUMAN, Q9NYG2 (See protein sequence)
Recommended Name: Palmitoyltransferase ZDHHC3  
Size: 299 amino acids; 34170 Da
Secondary accessions: Q53A17 Q96BL0
Alternative splicing: 2 isoforms:  Q9NYG2-1   Q9NYG2-2   

Explore the universe of human proteins at neXtProt for ZDHHC3: NX_Q9NYG2

Explore proteomics data for ZDHHC3 at MOPED

Post-translational modifications: 

  • Autopalmitoylated (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ZDHHC3 (Q9NYG2) (see all 5)
     MDHHCPW  KPDRAHH  WFIRDGCG  FVLFTMYIAL 


    See ZDHHC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001128651.1  NP_057682.1  

    ENSEMBL proteins: 
     ENSP00000404108   ENSP00000402545   ENSP00000296127   ENSP00000395502   ENSP00000345268  
     ENSP00000416132   ENSP00000408294   ENSP00000409755  

    ZDHHC3 Human Recombinant Protein Products:

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    Novus Biologicals ZDHHC3 Protein
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    Cloud-Clone Corp. Proteins for ZDHHC3

     
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    antibodies-online proteins for ZDHHC3 

     
    antibodies-online peptides for ZDHHC3

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    antibodies-online antibodies for ZDHHC3 (24 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZDHHC: Zinc fingers, DHHC-type

    1 InterPro protein domain:
     IPR001594 Znf_DHHC_palmitoyltrfase

    Graphical View of Domain Structure for InterPro Entry Q9NYG2

    ProtoNet protein and cluster: Q9NYG2

    1 Blocks protein domain: IPB001594 Zn-finger

    UniProtKB/Swiss-Prot: ZDHC3_HUMAN, Q9NYG2
    Domain: The DHHC domain is required for palmitoyltransferase activity (By similarity)
    Similarity: Belongs to the DHHC palmitoyltransferase family
    Similarity: Contains 1 DHHC-type zinc finger


    Find genes that share domains with ZDHHC3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZDHC3_HUMAN, Q9NYG2
    Function: Palmitoyltransferase with broad specificity. Palmitoylates GABA receptors on their gamma subunit
    (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability. Palmitoylates
    glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi (By similarity)
    Catalytic activity: Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA

         Enzyme Numbers (IUBMB): EC 2.3.1.2251 EC 2.3.12

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
    GO:0016409palmitoyltransferase activity IDA--
    GO:0016746transferase activity, transferring acyl groups ----
    GO:0019706protein-cysteine S-palmitoyltransferase activity IEA--
         
    Find genes that share ontologies with ZDHHC3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZDHHC3:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 

         1 MGI phenotypic allele for Zdhhc3 (no phenotypes)

    Find genes that share phenotypes with ZDHHC3           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZDHHC3

    miRNA
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    miRTarBase miRNAs that target ZDHHC3:
    hsa-mir-98-5p (MIRT027609), hsa-mir-7-5p (MIRT025824)

    Block miRNA regulation of human, mouse, rat ZDHHC3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZDHHC3 (see all 86):
    hsa-miR-3678-3p hsa-miR-520f hsa-miR-411 hsa-miR-219-5p hsa-miR-1304 hsa-miR-298 hsa-miR-3622b-3p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidZDHHC3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZDHHC3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZDHC3_HUMAN, Q9NYG2: Golgi apparatus membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    plasma membrane2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005794Golgi apparatus IDA16647879
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with ZDHHC3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZDHHC3
    Interactions:

        Search GeneGlobe Interaction Network for ZDHHC3

    Selected Interacting proteins for ZDHHC3 (Q9NYG22, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD1Q157972, 3MINT-62020 I2D: score=2 
    UBQLN4Q9NRR52, 3MINT-2873175 I2D: score=2 
    EWSR1Q018443I2D: score=3 
    MAP2K2P365073I2D: score=2 
    DLG4P783523I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006605protein targeting IEA--
    GO:0018345protein palmitoylation IDA--

    Find genes that share ontologies with ZDHHC3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZDHHC3 (ZDHC3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZDHHC3 gene (3 alternative transcripts): 
    NM_001135180.1  NM_001135179.1  NM_016598.2  

    Unigene Cluster for ZDHHC3:

    Zinc finger, DHHC-type containing 3
    Hs.61430  [show with all ESTs]
    Unigene Representative Sequence: NM_016598
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000339420(uc003cod.3 uc003cog.3 uc021wws.1) ENST00000466084(uc003coe.3)
    ENST00000443879 ENST00000296127 ENST00000424952 ENST00000479314 ENST00000342790
    ENST00000433512 ENST00000455235 ENST00000419642 ENST00000478669
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZDHHC3 (see all 86):
    hsa-miR-3678-3p hsa-miR-520f hsa-miR-411 hsa-miR-219-5p hsa-miR-1304 hsa-miR-298 hsa-miR-3622b-3p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidZDHHC3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZDHHC3
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    GenScript: all cDNA clones in your preferred vector (see all 2): ZDHHC3 (NM_016598)
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      QuantiTect SYBR Green Assays in human, mouse, rat ZDHHC3
      QuantiFast Probe-based Assays in human, mouse, rat ZDHHC3

    Additional mRNA sequence: 

    AF052182.1 AF247703.1 AF441791.1 AK000216.1 AK127837.1 AK299782.1 AL832057.1 AY605661.1 
    BC015467.1 BC020350.1 BC020424.1 BC038436.1 BC101284.2 BC101285.2 BC101286.1 BC101287.1 
    BC113070.1 

    20 DOTS entries:

    DT.213263  DT.86852866  DT.95355250  DT.100784266  DT.91803935  DT.409323  DT.102835693  DT.95338420 
    DT.97789758  DT.97804608  DT.120916346  DT.95107340  DT.95176844  DT.95259807  DT.100001040  DT.100740134 
    DT.95100237  DT.97839323  DT.100784268  DT.120916353 

    Selected AceView cDNA sequences (see all 357):

    BU948195 BM854705 BM728284 AL597825 CF125655 BE466143 BU157020 BE892561 
    CD370639 AI343605 BI829630 AW196576 BU678860 AI971088 CR625011 BM756211 
    BM670477 BM674266 BM854758 AA302998 AI308759 BC020424 BQ018971 AI983686 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC3 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
    SP1:                                            -                 -                                                   
    SP2:                                                              -                 -                                 
    SP3:                                            -                 -                 -                                 
    SP4:                                                              -                                                   
    SP5:                                            -                 -                                                   


    ECgene alternative splicing isoforms for ZDHHC3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZDHHC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAACAAAAT
    ZDHHC3 Expression
    About this image


    ZDHHC3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
    ZDHHC3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZDHHC3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.61430
        Custom PCR Arrays for ZDHHC3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZDHHC3 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zdhhc31 , 5 zinc finger, DHHC domain containing 31, 5 94.43(n)1
    97.32(a)1
      9 (73.66 cM)5
    690351  NM_026917.51  NP_081193.21 
     1230661605 
    chicken
    (Gallus gallus)
    Aves ZDHHC31 zinc finger, DHHC-type containing 3 81.61(n)
    90.64(a)
      420705  XM_004939461.1  XP_004939518.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZDHHC36
    zinc finger, DHHC-type containing 3
    81(a)
    1 ↔ 1
    GL343224.1(33415-54939)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.123032 Xenopus laevis transcribed sequence with weak similarity more 77.82(n)    BJ067314.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zdhhc3b1 zinc finger, DHHC-type containing 3b 75.03(n)
    82.37(a)
      777709  NM_001077757.1  NP_001071225.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG83141 , 3 CG83141 57(a)3
    62.95(n)1
    63.75(a)1
      52D93
    367571  NM_137226.41  NP_611070.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F33D11.121 , 3 F33D11.121 50(a)
    (best of 2)3
    57.4(n)1
    58.09(a)1
      I(5871167-5872804)3
    1722571  NM_059301.41  NP_491702.11 


    ENSEMBL Gene Tree for ZDHHC3 (if available)
    TreeFam Gene Tree for ZDHHC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZDHHC3 gene
    ZDHHC212  ZDHHC72  ZDHHC202  ZDHHC162  ZDHHC62  ZDHHC22  ZDHHC152  
    6 SIMAP similar genes for ZDHHC3 using alignment to 7 protein entries:     ZDHC3_HUMAN (see all proteins):
    ZDHHC2    ZDHHC7    ZDHHC23    ZDHHC1    ZDHHC18    ZDHHC5

    Find genes that share paralogs with ZDHHC3           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for ZDHHC3
    PGOHUM00000262392 PGOHUM00000235704


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZDHHC3 (see all 998)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs9378321,2
    H--44956690(+) CATAAG/TGAAGG 2 -- ds50015Minor allele frequency- T:0.00MN NS EA 604
    rs1408590851,2
    --44956706(+) GCCCAA/TGGGTT 2 -- ds50010--------
    rs66221,2
    C,F,A,H--44956860(+) TCAGTT/CTGAGG 2 -- ut3141Minor allele frequency- C:0.29MN EA NA NS WA CSA 3700
    rs753290031,2
    F--44956944(+) CAGGGT/CTGGAC 2 -- ut311Minor allele frequency- C:0.01WA 118
    rs1859124111,2
    --44957097(+) TCACCC/GCAGCC 2 -- ut310--------
    rs1152875281,2
    C,F--44957339(+) TGCTGC/TCCCCT 2 -- ut311Minor allele frequency- T:0.03WA 118
    rs1168506021,2
    C,F--44957452(+) AAATAG/AGGGGC 2 -- ut311Minor allele frequency- A:0.03EA 120
    rs1911612611,2
    --44957494(+) GTGAGC/TGTCAA 2 -- ut310--------
    rs1461536601,2
    --44957556(+) ATGTCA/GTCATT 2 -- ut310--------
    rs756645491,2
    C--44957627(+) CCAATA/C/GTCTTT 4 -- ut312CSA NA 121

    HapMap Linkage Disequilibrium report for ZDHHC3 (44956749 - 45017677 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZDHHC3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834675CNV Gain17160897
    nsv834676CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZDHHC3
    DNA2.0 Custom Variant and Variant Library Synthesis for ZDHHC3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZDHHC3 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with ZDHHC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Golgi-specific DHHC zinc finger protein GODZ mediates membrane Ca2+ transport. (PubMed id 19955568)1, 3 Hines R.M....Quamme G.A. (J. Biol. Chem. 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes. (PubMed id 23687301)1 Oku S....Fukata M. (J. Biol. Chem. 2013)
    4. Palmitoylation by DHHC3 is critical for the function, expression, and stability of integrin I+6I^4. (PubMed id 22314500)1 Sharma C....Hemler M.E. (Cell. Mol. Life Sci. 2012)
    5. Regulation in the targeting of TRAIL receptor 1 to cell surface via GODZ for TRAIL sensitivity in tumor cells. (PubMed id 22240897)1 Oh Y....Jung Y.K. (Cell Death Differ. 2012)
    6. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (Mol. Syst. Biol. 2009)
    7. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (Science 2009)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    9. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. (PubMed id 16647879)1 Ohno Y....Igarashi Y. (Biochim. Biophys. Acta 2006)
    10. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51304 HGNC: 18470 AceView: ZDHHC3andFLJ20209 Ensembl:ENSG00000163812 euGenes: HUgn51304
    ECgene: ZDHHC3 H-InvDB: ZDHHC3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZDHHC3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZDHHC3 gene:
    Search GeneIP for patents involving ZDHHC3

    GeneCards and IP:
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