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Aliases for ZDHHC24 Gene

Aliases for ZDHHC24 Gene

  • Zinc Finger DHHC-Type Containing 24 2 3 5
  • Zinc Finger DHHC Domain-Containing Protein 24 3 4
  • DHHC-24 3 4
  • Zinc Finger, DHHC Domain Containing 24 3
  • Probable Palmitoyltransferase ZDHHC24 3
  • EC 2.3.1.225 4

External Ids for ZDHHC24 Gene

Previous GeneCards Identifiers for ZDHHC24 Gene

  • GC11M066064
  • GC11M066306
  • GC11M062638
  • GC11M066288

Summaries for ZDHHC24 Gene

GeneCards Summary for ZDHHC24 Gene

ZDHHC24 (Zinc Finger DHHC-Type Containing 24) is a Protein Coding gene. GO annotations related to this gene include protein-cysteine S-palmitoyltransferase activity.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC24 Gene

Genomics for ZDHHC24 Gene

Regulatory Elements for ZDHHC24 Gene

Enhancers for ZDHHC24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G066636 1.4 ENCODE dbSUPER 11.3 -92.1 -92098 3.8 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ACTN3 EIF1AD CORO1B RBM4B ENSG00000258297 RNU4-39P RBM14 RBM14-RBM4 ZDHHC24 ENSG00000255320
GH11G066578 1.2 Ensembl ENCODE 12.3 -33.0 -33046 0.7 HDGF ATF1 ARID4B SIN3A ZNF2 ZBTB7B SLC30A9 ZNF143 FOS REST RBM14 LOC105369352 ENSG00000258297 ENSG00000254461 MUS81 ZDHHC24 ACTN3 RBM4B DPP3 LOC101928069
GH11G066606 1.3 Ensembl ENCODE dbSUPER 11.2 -61.6 -61603 1.9 RAD21 YY1 POLR3A ZNF548 IKZF2 SP5 CEBPB NR2F2 TGIF2 CEBPA ACTN3 ENSG00000258297 MUS81 RBM14 RBM4 ZDHHC24 EIF1AD LOC105369352 MRPL11 PC
GH11G066694 1.3 Ensembl ENCODE 11 -148.6 -148613 1.0 HDGF CREB3L1 ARNT ARID4B SIN3A ZNF2 SLC30A9 ZNF143 DEK REST SPTBN2 C11orf80 RCE1 ZDHHC24 ACTN3 LRFN4 PC RNU7-23P BRD9P1 RNU1-84P
GH11G066880 1.4 Ensembl ENCODE dbSUPER 10 -336.3 -336308 3.7 PKNOX1 FOXA2 ARID4B SIN3A ZNF2 ZNF143 FOS ZNF263 REST ZNF579 C11orf80 ACTN3 CTSF RAD9A RCE1 LRFN4 PC RNU7-23P RHOD LOC100505504
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZDHHC24 on UCSC Golden Path with GeneCards custom track

Promoters for ZDHHC24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040981 38 1601 HDGF PKNOX1 CREB3L1 ARNT SIN3A ARID4B DMAP1 YBX1 YY1 ZNF207

Genomic Location for ZDHHC24 Gene

Chromosome:
11
Start:
66,520,637 bp from pter
End:
66,546,238 bp from pter
Size:
25,602 bases
Orientation:
Minus strand

Genomic View for ZDHHC24 Gene

Genes around ZDHHC24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC24 Gene

Proteins for ZDHHC24 Gene

  • Protein details for ZDHHC24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UX98-ZDH24_HUMAN
    Recommended name:
    Probable palmitoyltransferase ZDHHC24
    Protein Accession:
    Q6UX98
    Secondary Accessions:
    • Q6PEW7
    • Q9BSJ0

    Protein attributes for ZDHHC24 Gene

    Size:
    284 amino acids
    Molecular mass:
    30176 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZDHHC24 Gene

Post-translational modifications for ZDHHC24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZDHHC24 Gene

No data available for DME Specific Peptides for ZDHHC24 Gene

Domains & Families for ZDHHC24 Gene

Gene Families for ZDHHC24 Gene

Protein Domains for ZDHHC24 Gene

Suggested Antigen Peptide Sequences for ZDHHC24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UX98

UniProtKB/Swiss-Prot:

ZDH24_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family.
genes like me logo Genes that share domains with ZDHHC24: view

Function for ZDHHC24 Gene

Molecular function for ZDHHC24 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Enzyme Numbers (IUBMB) for ZDHHC24 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC24: view

Phenotypes for ZDHHC24 Gene

MGI mutant phenotypes for ZDHHC24:
inferred from 1 alleles
GenomeRNAi human phenotypes for ZDHHC24:
genes like me logo Genes that share phenotypes with ZDHHC24: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ZDHHC24

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC24 Gene

Localization for ZDHHC24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC24 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC24 gene
Compartment Confidence
plasma membrane 3
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ZDHHC24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC24: view

Pathways & Interactions for ZDHHC24 Gene

SuperPathways for ZDHHC24 Gene

No Data Available

Interacting Proteins for ZDHHC24 Gene

Gene Ontology (GO) - Biological Process for ZDHHC24 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC24 Gene

Drugs & Compounds for ZDHHC24 Gene

(1) Drugs for ZDHHC24 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for ZDHHC24 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
genes like me logo Genes that share compounds with ZDHHC24: view

Transcripts for ZDHHC24 Gene

Unigene Clusters for ZDHHC24 Gene

Zinc finger, DHHC-type containing 24:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC24 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b
SP1: -
SP2: -
SP3:

Relevant External Links for ZDHHC24 Gene

GeneLoc Exon Structure for
ZDHHC24
ECgene alternative splicing isoforms for
ZDHHC24

Expression for ZDHHC24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZDHHC24 Gene

Protein differential expression in normal tissues from HIPED for ZDHHC24 Gene

This gene is overexpressed in Placenta (39.6) and CD8 Tcells (29.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZDHHC24 Gene



Protein tissue co-expression partners for ZDHHC24 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZDHHC24 Gene:

ZDHHC24

SOURCE GeneReport for Unigene cluster for ZDHHC24 Gene:

Hs.659933
genes like me logo Genes that share expression patterns with ZDHHC24: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC24 Gene

Orthologs for ZDHHC24 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZDHHC24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC24 34 35
  • 99.37 (n)
dog
(Canis familiaris)
Mammalia ZDHHC24 34 35
  • 91.9 (n)
cow
(Bos Taurus)
Mammalia ZDHHC24 34 35
  • 89.79 (n)
rat
(Rattus norvegicus)
Mammalia Zdhhc24 34
  • 84.39 (n)
mouse
(Mus musculus)
Mammalia Zdhhc24 34 16 35
  • 84.15 (n)
oppossum
(Monodelphis domestica)
Mammalia ZDHHC24 35
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZDHHC24 35
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc24 34
  • 50.52 (n)
zebrafish
(Danio rerio)
Actinopterygii zdhhc24 34 35
  • 53.26 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009199 34
  • 49.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10344 34 35
  • 46.79 (n)
CG4676 35
  • 27 (a)
OneToMany
CG13029 35
  • 24 (a)
OneToMany
CG17195 35
  • 23 (a)
OneToMany
CG17196 35
  • 23 (a)
OneToMany
CG4956 35
  • 23 (a)
OneToMany
CG17198 35
  • 22 (a)
OneToMany
CG18810 35
  • 22 (a)
OneToMany
CG17197 35
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dhhc-1 34 35
  • 42.03 (n)
dhhc-10 35
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3283 35
  • 25 (a)
OneToMany
-- 35
  • 21 (a)
OneToMany
Species where no ortholog for ZDHHC24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC24 Gene

ENSEMBL:
Gene Tree for ZDHHC24 (if available)
TreeFam:
Gene Tree for ZDHHC24 (if available)

Paralogs for ZDHHC24 Gene

No data available for Paralogs for ZDHHC24 Gene

Variants for ZDHHC24 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC24 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1057517143 Pathogenic 66,523,496(+) GCGCC(C/T)AGCCT intron-variant, reference, stop-gained
rs113624356 Pathogenic 66,526,181(+) CATCA(G/T)GACCA intron-variant, reference, missense
rs113994179 Pathogenic 66,523,453(+) TTCCA(C/G)AGAGA intron-variant
rs113994180 Pathogenic 66,529,817(+) TCCAC(A/G)GCCAT intron-variant, splice-acceptor-variant
rs121917777 Pathogenic 66,531,692(+) CCCTG(A/G/T)AGACC intron-variant, reference, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC24 Gene

Variant ID Type Subtype PubMed ID
nsv522277 CNV loss 19592680

Variation tolerance for ZDHHC24 Gene

Residual Variation Intolerance Score: 63.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.71; 86.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZDHHC24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZDHHC24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC24 Gene

Disorders for ZDHHC24 Gene

Relevant External Links for ZDHHC24

Genetic Association Database (GAD)
ZDHHC24
Human Genome Epidemiology (HuGE) Navigator
ZDHHC24
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZDHHC24

No disorders were found for ZDHHC24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC24 Gene

Publications for ZDHHC24 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) (Nat. Genet. 2011) 3 64

Products for ZDHHC24 Gene

Sources for ZDHHC24 Gene

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