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ZDHHC24 Gene

protein-coding   GIFtS: 43
GCID: GC11M066288

Zinc Finger, DHHC-Type Containing 24

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, DHHC-Type Containing 241 2
Zinc Finger DHHC Domain-Containing Protein 242 3
DHHC-242 3
Probable Palmitoyltransferase ZDHHC242
Zinc Finger, DHHC Domain Containing 242
EC 2.3.1.2253

External Ids:    HGNC: 273871   Entrez Gene: 2543592   Ensembl: ENSG000001741657   UniProtKB: Q6UX983   

Export aliases for ZDHHC24 gene to outside databases

Previous GC identifers: GC11M066064 GC11M066306 GC11M062638


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZDHHC24 Gene:
ZDHHC24 (zinc finger, DHHC-type containing 24) is a protein-coding gene. GO annotations related to this gene include transferase activity, transferring acyl groups.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZDHHC24 gene promoter:
         GR   Spz1   p53   AP-1   HSF1 (long)   CUTL1   POU2F1   POU2F1a   GR-alpha   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZDHHC24 promoter sequence
   Search Chromatin IP Primers for ZDHHC24

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZDHHC24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.2   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.2

ZDHHC24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZDHHC24 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M066288:  view genomic region     (about GC identifiers)

Start:
66,288,108 bp from pter      End:
66,313,709 bp from pter
Size:
25,602 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZDH24_HUMAN, Q6UX98 (See protein sequence)
Recommended Name: Probable palmitoyltransferase ZDHHC24  
Size: 284 amino acids; 30176 Da
Secondary accessions: Q6PEW7 Q9BSJ0

Explore the universe of human proteins at neXtProt for ZDHHC24: NX_Q6UX98

Explore proteomics data for ZDHHC24 at MOPED


See ZDHHC24 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_997223.1  
ENSEMBL proteins: 
 ENSP00000436503   ENSP00000431321   ENSP00000309429  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ZDHHC: Zinc fingers, DHHC-type

1 InterPro protein domain:
 IPR001594 Znf_DHHC_palmitoyltrfase

Graphical View of Domain Structure for InterPro Entry Q6UX98

ProtoNet protein and cluster: Q6UX98

1 Blocks protein domain: IPB001594 Zn-finger

UniProtKB/Swiss-Prot: ZDH24_HUMAN, Q6UX98
Domain: The DHHC domain is required for palmitoyltransferase activity (By similarity)
Similarity: Belongs to the DHHC palmitoyltransferase family
Similarity: Contains 1 DHHC-type zinc finger


Find genes that share domains with ZDHHC24           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ZDH24_HUMAN, Q6UX98
Catalytic activity: Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA

     Enzyme Number (IUBMB): EC 2.3.1.2251

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008270zinc ion binding IEA--
GO:0016746transferase activity, transferring acyl groups ----
GO:0019706protein-cysteine S-palmitoyltransferase activity IEA--
     
Find genes that share ontologies with ZDHHC24           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for ZDHHC24:
 Increased G1 DNA content 

     1 MGI mutant phenotype (inferred from 1 allele(MGI details for Zdhhc24):
 normal 

Find genes that share phenotypes with ZDHHC24           About GenesLikeMe

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ZDH24_HUMAN, Q6UX98: Membrane; Multi-pass membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane3
cytoskeleton1
endoplasmic reticulum1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with ZDHHC24           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Interactions:

    Search GeneGlobe Interaction Network for ZDHHC24

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for ZDHHC24 (ZDH24)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ZDHHC24 gene: 
NM_207340.1  

Unigene Cluster for ZDHHC24:

Zinc finger, DHHC-type containing 24
Hs.659933  [show with all ESTs]
Unigene Representative Sequence: AK022244
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000534073 ENST00000526986(uc009yrg.2) ENST00000310442(uc001oin.1)
ENST00000525925
miRNA
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hsa-miR-149 hsa-miR-490-3p
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Additional mRNA sequence: 

AK022244.1 AK301787.1 AK310561.1 AY358448.1 BC005015.1 BC057833.1 

8 DOTS entries:

DT.100772249  DT.100672674  DT.100031280  DT.203214  DT.91745610  DT.100839104  DT.100760154  DT.100838305 

Selected AceView cDNA sequences (see all 107):

BU633237 AI805053 BE904570 BC005015 CA398129 BQ064953 AK022244 BI916652 
BG113193 BM923817 CR623920 CA425934 AW006720 BU632065 BM664925 CR616301 
BE910102 CK905601 BQ222156 BM791695 BM702244 AI624274 CD518858 BM894080 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC24    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b
SP1:                          -               
SP2:                          -               
SP3:                                          


ECgene alternative splicing isoforms for ZDHHC24

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZDHHC24 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGAGTGGGCT
ZDHHC24 Expression
About this image

ZDHHC24 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ZDHHC24 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.659933
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for ZDHHC24 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Zdhhc241 , 5 zinc finger, DHHC domain containing 241, 5 84.15(n)1
87.68(a)1
  19 (4.13 cM)5
706051  NM_027476.31  NP_081752.21 
 48786685 
lizard
(Anolis carolinensis)
Reptilia ZDHHC246
zinc finger, DHHC-type containing 24
49(a)
1 ↔ 1
GL343832.1(81620-87257)
tropical clawed frog
(Xenopus tropicalis)
Amphibia zdhhc241 zinc finger, DHHC-type containing 24 50.52(n)
44.92(a)
  100170592  NM_001130363.1  NP_001123835.1 
zebrafish
(Danio rerio)
Actinopterygii zdhhc241 zinc finger, DHHC-type containing 24 53.26(n)
44.93(a)
  436596  NM_001002324.1  NP_001002324.1 
fruit fly
(Drosophila melanogaster)
Insecta CG103441 CG10344 46.79(n)
37.95(a)
  37565  NM_137827.2  NP_611671.1 
worm
(Caenorhabditis elegans)
Secernentea dhhc-11 dhhc-1 42.03(n)
31.52(a)
  181606  NM_078109.4  NP_510510.1 


ENSEMBL Gene Tree for ZDHHC24 (if available)
TreeFam Gene Tree for ZDHHC24 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZDHHC24 (see all 142)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs286878881,2
C,F--66306301(+) TTCTTT/CACCTT 1 -- int13Minor allele frequency- C:0.10WA CSA 122
rs37375251,2
C,F,H--66306355(-) TGTGCT/CTTTGC 1 -- int117Minor allele frequency- C:0.13EA NS NA 3892
rs1871585551,2
--66306462(+) AGAGAA/GGTTCC 1 -- int10--------
rs115520451,2
C,F--66306568(+) CTTGGC/TGTGCT 1 -- int12Minor allele frequency- T:0.00NA 4
rs1435719741,2
--66306650(+) CAGTTG/TCCAGG 1 -- int10--------
rs1472924651,2
--66306862(+) TAGGCA/GGGCAG 1 -- ut310--------
rs31800631,2
C,H--66306905(-) AACATC/TTGCAT 1 -- ut314Minor allele frequency- T:0.00MN NS NA 368
rs1998731691,2
C--66306970(+) CCTTCC/TTCCCT 1 -- ut310--------
rs1411120141,2
C,F--66307174(+) TCCCAT/CGTGGT 2 /T syn12Minor allele frequency- C:0.00NA EU 4441
rs1498668501,2
C,F--66307201(+) AGCATC/TCCATG 2 G syn11Minor allele frequency- T:0.00NA 4228

HapMap Linkage Disequilibrium report for ZDHHC24 (66288108 - 66313709 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for ZDHHC24:    About this table    
Variant IDTypeSubtypePubMed ID
nsv897787CNV Loss21882294
nsv522277CNV Loss19592680
dgv1187n71CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with ZDHHC24           About GenesLikeMe

Genetic Association Database (GAD): ZDHHC24
Human Genome Epidemiology (HuGE) Navigator: ZDHHC24 (3 documents)

Export disorders for ZDHHC24 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ZDHHC24 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ZDHHC24)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
  4. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PubMed id 21926972)1 (Nat. Genet. 2011)
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 254359 HGNC: 27387 AceView: LOC254359 Ensembl:ENSG00000174165 euGenes: HUgn254359
ECgene: ZDHHC24 H-InvDB: ZDHHC24

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ZDHHC24 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ZDHHC24 gene:
Search GeneIP for patents involving ZDHHC24

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZDHHC24
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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