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Aliases for ZDHHC24 Gene

Aliases for ZDHHC24 Gene

  • Zinc Finger DHHC-Type Containing 24 2 3 5
  • Zinc Finger DHHC Domain-Containing Protein 24 3 4
  • DHHC-24 3 4
  • Zinc Finger, DHHC Domain Containing 24 3
  • Probable Palmitoyltransferase ZDHHC24 3
  • EC 4

External Ids for ZDHHC24 Gene

Previous GeneCards Identifiers for ZDHHC24 Gene

  • GC11M066064
  • GC11M066306
  • GC11M062638
  • GC11M066288

Summaries for ZDHHC24 Gene

GeneCards Summary for ZDHHC24 Gene

ZDHHC24 (Zinc Finger DHHC-Type Containing 24) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein-cysteine S-palmitoyltransferase activity.

Additional gene information for ZDHHC24 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC24 Gene

Genomics for ZDHHC24 Gene

GeneHancer (GH) Regulatory Elements for ZDHHC24 Gene

Promoters and enhancers for ZDHHC24 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I066542 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.2 246 6.2 HDGF PKNOX1 ARNT ARID4B SIN3A YY1 E2F8 ZNF207 ZNF143 FOS ACTN3 ZDHHC24 KDM2A EIF1AD CTSF DPP3 RBM14 LOC105369352 SSSCA1 RBM4
GH11I066636 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.3 -92.1 -92098 3.8 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 RBM4 ACTN3 EIF1AD RBM14 KDM2A SART1 ENSG00000255320 ENSG00000258297 CORO1B RELA
GH11I066676 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.8 -131.6 -131583 2.8 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 GC11P066677 RBM4B RN7SL12P SPTBN2 C11orf80 LRFN4 PC ZDHHC24 ACTN3 RBM14-RBM4
GH11I066508 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.6 +36.1 36109 2.9 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 ZNF213 ENSG00000256349 BBS1 ENSG00000258297 RBM14 RBM4 DPP3 EIF1AD KDM2A PCNX3 ENSG00000245156
GH11I066606 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.2 -61.6 -61603 1.8 RAD21 YY1 POLR3A ZNF548 IKZF2 RUNX3 SMARCA5 RXRA SP5 CEBPB RBM4 ACTN3 ENSG00000258297 MUS81 RBM14 KDM2A ZDHHC24 EIF1AD LOC105369352 RELA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZDHHC24 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZDHHC24 gene promoter:

Genomic Locations for ZDHHC24 Gene

Genomic Locations for ZDHHC24 Gene
25,602 bases
Minus strand

Genomic View for ZDHHC24 Gene

Genes around ZDHHC24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC24 Gene

Proteins for ZDHHC24 Gene

  • Protein details for ZDHHC24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable palmitoyltransferase ZDHHC24
    Protein Accession:
    Secondary Accessions:
    • Q6PEW7
    • Q9BSJ0

    Protein attributes for ZDHHC24 Gene

    284 amino acids
    Molecular mass:
    30176 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZDHHC24 Gene

Post-translational modifications for ZDHHC24 Gene

No Post-translational modifications

Other Protein References for ZDHHC24 Gene

No data available for DME Specific Peptides for ZDHHC24 Gene

Domains & Families for ZDHHC24 Gene

Gene Families for ZDHHC24 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for ZDHHC24 Gene

Suggested Antigen Peptide Sequences for ZDHHC24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
genes like me logo Genes that share domains with ZDHHC24: view

Function for ZDHHC24 Gene

Molecular function for ZDHHC24 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Enzyme Numbers (IUBMB) for ZDHHC24 Gene

Phenotypes From GWAS Catalog for ZDHHC24 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC24: view

Phenotypes for ZDHHC24 Gene

MGI mutant phenotypes for ZDHHC24:
inferred from 1 alleles
GenomeRNAi human phenotypes for ZDHHC24:
genes like me logo Genes that share phenotypes with ZDHHC24: view

Animal Model Products

miRNA for ZDHHC24 Gene

miRTarBase miRNAs that target ZDHHC24

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC24 Gene

Localization for ZDHHC24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC24 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC24 gene
Compartment Confidence
plasma membrane 3
cytosol 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZDHHC24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC24: view

Pathways & Interactions for ZDHHC24 Gene

SuperPathways for ZDHHC24 Gene

No Data Available

Interacting Proteins for ZDHHC24 Gene

Gene Ontology (GO) - Biological Process for ZDHHC24 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZDHHC24 Gene

Drugs & Compounds for ZDHHC24 Gene

(1) Drugs for ZDHHC24 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0

(1) Additional Compounds for ZDHHC24 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZDHHC24: view

Transcripts for ZDHHC24 Gene

Unigene Clusters for ZDHHC24 Gene

Zinc finger, DHHC-type containing 24:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC24 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b
SP1: -
SP2: -

Relevant External Links for ZDHHC24 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZDHHC24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZDHHC24 Gene

Protein differential expression in normal tissues from HIPED for ZDHHC24 Gene

This gene is overexpressed in Placenta (39.6) and CD8 Tcells (29.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZDHHC24 Gene

Protein tissue co-expression partners for ZDHHC24 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZDHHC24 Gene:


SOURCE GeneReport for Unigene cluster for ZDHHC24 Gene:

genes like me logo Genes that share expression patterns with ZDHHC24: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC24 Gene

Orthologs for ZDHHC24 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZDHHC24 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZDHHC24 33 34
  • 99.37 (n)
(Canis familiaris)
Mammalia ZDHHC24 33 34
  • 91.9 (n)
(Bos Taurus)
Mammalia ZDHHC24 33 34
  • 89.79 (n)
(Rattus norvegicus)
Mammalia Zdhhc24 33
  • 84.39 (n)
(Mus musculus)
Mammalia Zdhhc24 33 16 34
  • 84.15 (n)
(Monodelphis domestica)
Mammalia ZDHHC24 34
  • 75 (a)
(Anolis carolinensis)
Reptilia ZDHHC24 34
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc24 33
  • 50.52 (n)
(Danio rerio)
Actinopterygii LOC100536239 33
  • 53.26 (n)
zdhhc24 34
  • 38 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009199 33
  • 49.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10344 34 33
  • 46.79 (n)
CG4676 34
  • 27 (a)
CG13029 34
  • 24 (a)
CG17195 34
  • 23 (a)
CG17196 34
  • 23 (a)
CG4956 34
  • 23 (a)
CG17198 34
  • 22 (a)
CG18810 34
  • 22 (a)
CG17197 34
  • 21 (a)
(Caenorhabditis elegans)
Secernentea dhhc-1 33 34
  • 42.03 (n)
dhhc-10 34
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3283 34
  • 25 (a)
-- 34
  • 21 (a)
Species where no ortholog for ZDHHC24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC24 Gene

Gene Tree for ZDHHC24 (if available)
Gene Tree for ZDHHC24 (if available)

Paralogs for ZDHHC24 Gene

No data available for Paralogs for ZDHHC24 Gene

Variants for ZDHHC24 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC24 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1015901096 uncertain-significance, Bardet-Biedl syndrome 66,532,892(-) G/A genic_downstream_transcript_variant, intron_variant
rs1057516330 likely-pathogenic, Bardet-Biedl syndrome 66,521,331(-) GG/G downstream_transcript_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1057516371 likely-pathogenic, Bardet-Biedl syndrome 66,523,751(-) CCC/CC genic_downstream_transcript_variant, intron_variant
rs1057516427 likely-pathogenic, Bardet-Biedl syndrome 66,523,480(-) C/A genic_downstream_transcript_variant, intron_variant
rs1057516533 conflicting-interpretations-of-pathogenicity, Bardet-Biedl syndrome 66,523,842(-) TTT/TT genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC24 Gene

Variant ID Type Subtype PubMed ID
nsv522277 CNV loss 19592680

Variation tolerance for ZDHHC24 Gene

Residual Variation Intolerance Score: 63.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.71; 86.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZDHHC24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC24 Gene

Disorders for ZDHHC24 Gene

Additional Disease Information for ZDHHC24

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZDHHC24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC24 Gene

Publications for ZDHHC24 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) Psychiatric GWAS Consortium Bipolar Disorder Working Group (Nature genetics 2011) 3 58

Products for ZDHHC24 Gene

Sources for ZDHHC24 Gene

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