ZDHHC24 Gene
protein-coding GIFtS: 40
GCID: GC11M066288
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|
zinc finger, DHHC-type containing 24
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Aliases
for ZDHHC24 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger, DHHC-Type Containing 241 2 | | Zinc Finger DHHC Domain-Containing Protein 242 3 | | DHHC-242 3 | | Probable Palmitoyltransferase ZDHHC242 | | Zinc Finger, DHHC Domain Containing 242 | | EC 2.3.1.-3 |
Export aliases for ZDHHC24 gene to outside databasesPrevious GC identifers: GC11M066064 GC11M066306 GC11M062638 |
Summaries
for ZDHHC24 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ZDHHC24 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZDHHC24 gene promoter:
GR Spz1 p53 AP-1 HSF1 (long) CUTL1 POU2F1 POU2F1a GR-alpha TGIF
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZDHHC24
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZDHHC24 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.2 Ensembl cytogenetic band: 11q13.2 HGNC cytogenetic band: 11q13.2ZDHHC24 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M066288: view genomic region
(about GC identifiers)
Start:
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66,288,108 bp from pter |
End:
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66,313,709 bp from pter |
Size:
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25,602 bases |
Orientation:
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minus strand |
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Proteins
for ZDHHC24 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZDH24_HUMAN, Q6UX98 (See
protein sequence)Recommended Name: Probable palmitoyltransferase ZDHHC24 Size: 284 amino acids; 30176 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q6PEW7 Q9BSJ0Explore the universe of human proteins at neXtProt for ZDHHC24: NX_Q6UX98
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6UX98
ZDHHC24 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_997223.1
ENSEMBL proteins: ENSP00000436503 ENSP00000431321 ENSP00000309429
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
ZDHHC24 for ontologies About GeneDecksing
ZDHHC24 Antibody Products:
Assay Products for ZDHHC24: |
Protein
Domains /
Families
for ZDHHC24 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZDHHC24 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6UX98ProtoNet protein and cluster: Q6UX98 1 Blocks protein family: IPB001594 Zn-finger
UniProtKB/Swiss-Prot: ZDH24_HUMAN, Q6UX98Domain: The DHHC domain is required for palmitoyltransferase activity (By similarity)Similarity: Belongs to the DHHC palmitoyltransferase familySimilarity: Contains 1 DHHC-type zinc finger |
Function
for ZDHHC24 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZDH24_HUMAN, Q6UX98Catalytic activity: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoAEnzyme Number (IUBMB): EC 2.3.1.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC24 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC24
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: ZDHHC24 (NM_207340) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZDHHC24 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZDHHC24 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- | | GO:0016746 | transferase activity, transferring acyl groups |
IEA | -- |
ZDHHC24 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZDHHC24:
|
Pathways & Interactions
for ZDHHC24 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZDHHC24
|
Drugs & Compounds
for ZDHHC24 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZDHHC24
Search CenterWatch for drugs/clinical trials and news about ZDHHC24 / ZDH24
|
Transcripts
for ZDHHC24 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZDHHC24 gene: NM_207340.1 Unigene Cluster for ZDHHC24: Zinc finger, DHHC-type containing 24 Hs.744378 [show with all ESTs]Unigene Representative Sequence: AK0222444 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000534073 ENST00000526986(uc009yrg.2) ENST00000310442(uc001oin.1)
ENST00000525925
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC24 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC24
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZDHHC24 (NM_207340) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZDHHC24 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZDHHC24 |
Additional cDNA sequence: AK022244.1 AK301787.1 AK310561.1 AY358448.1 BC005015.1 BC057833.1 8 DOTS entries: DT.100772249 DT.100672674 DT.100031280 DT.203214 DT.91745610 DT.100839104 DT.100760154 DT.100838305 24/107 AceView cDNA sequences (see all 107): BQ064953 BE910102 BM791695 AI805053 BU632065 BC057833 CR616301 CA398129 BG113193 BQ222156 BM702244 CR623920 BC005015 CA425934 CD518858 CK905601 BE904570 AK022244 AW006720 BM664925 AI624274 BM894080 BU633237 BM923817
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC24 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b |
|---|
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| SP1: | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZDHHC24
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Expression
for ZDHHC24 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZDHHC24 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAGTGGGCT
About this image
See ZDHHC24 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZDHHC24
SOURCE GeneReport for Unigene cluster: Hs.744378
SABiosciences Custom PCR Arrays for ZDHHC24
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZDHHC24
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZDHHC24 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZDHHC24 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZDHHC24 |
Orthologs
for ZDHHC24 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZDHHC24 gene from 4/17 species (see all 17) About this table
ENSEMBL Gene Tree for ZDHHC24 (if available)
TreeFam Gene Tree for ZDHHC24 (if available) |
Paralogs
for ZDHHC24 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZDHHC24 gene
- ZDHHC222
ZDHHC24 for paralogs About GeneDecksing
|
Genomic Variants
for ZDHHC24 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZDHHC24 (66288108 - 66313709 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZDHHC24: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZDHHC24 |
|
Disorders
/ Diseases
for ZDHHC24 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZDHHC24 for disorders About MalaCards
ZDHHC24 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: ZDHHC24 (3 documents)
Export disorders for ZDHHC24 gene to outside databases
|
Publications
for ZDHHC24 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZDHHC24 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZDHHC24) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Large-scale genome-wide association analysis of bipol ar disorder identifies a new susceptibility locus near ODZ4. (PubMed id 21926972)1 Sklar P....Purcell S.M. (2011)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for ZDHHC24 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZDHHC24 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZDHHC24 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZDHHC24 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZDHHC24 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZDHHC24 gene:
Search GeneIP for patents involving ZDHHC24
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZDHHC24 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZDHHC24 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZDHHC24 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZDHHC24 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZDHHC24 | | OriGene 3'-UTR Clone for ZDHHC24 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC24 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC24 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZDHHC24 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZDHHC24 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZDHHC24 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZDHHC24 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZDHHC24 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZDHHC24 |
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 | | | ZDHHC24 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for ZDHHC24 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZDHHC24 |
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