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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZDHHC24 Gene

protein-coding   GIFtS: 43
GCID: GC11M066288

Zinc Finger, DHHC-Type Containing 24

  Search for ZDHHC24
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger, DHHC-Type Containing 241 2
Zinc Finger DHHC Domain-Containing Protein 242 3
DHHC-242 3
Probable Palmitoyltransferase ZDHHC242
Zinc Finger, DHHC Domain Containing 242
EC 2.3.1.-3

External Ids:    HGNC: 273871   Entrez Gene: 2543592   Ensembl: ENSG000001741657   UniProtKB: Q6UX983   

Export aliases for ZDHHC24 gene to outside databases

Previous GC identifers: GC11M066064 GC11M066306 GC11M062638


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZDHHC24 Gene: 
ZDHHC24 (zinc finger, DHHC-type containing 24) is a protein-coding gene. GO annotations related to this gene include transferase activity, transferring acyl groups and zinc ion binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZDHHC24 gene promoter:
         GR   Spz1   p53   AP-1   HSF1 (long)   CUTL1   POU2F1   POU2F1a   GR-alpha   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZDHHC24 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZDHHC24

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZDHHC24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.2   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.2

ZDHHC24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZDHHC24 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M066288:  view genomic region     (about GC identifiers)

Start:
66,288,108 bp from pter      End:
66,313,709 bp from pter
Size:
25,602 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZDH24_HUMAN, Q6UX98 (See protein sequence)
Recommended Name: Probable palmitoyltransferase ZDHHC24  
Size: 284 amino acids; 30176 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q6PEW7 Q9BSJ0

Explore the universe of human proteins at neXtProt for ZDHHC24: NX_Q6UX98

Explore proteomics data for ZDHHC24 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6UX98

  • ZDHHC24 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZDHHC24 Protein Expression
    REFSEQ proteins: NP_997223.1  
    ENSEMBL proteins: 
     ENSP00000436503   ENSP00000431321   ENSP00000309429  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    ZDHHC24 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZDHHC: Zinc fingers, DHHC-type

    1 InterPro protein domain:
     IPR001594 Znf_DHHC_palmitoyltrfase

    Graphical View of Domain Structure for InterPro Entry Q6UX98

    ProtoNet protein and cluster: Q6UX98

    1 Blocks protein domain: IPB001594 Zn-finger

    UniProtKB/Swiss-Prot: ZDH24_HUMAN, Q6UX98
    Domain: The DHHC domain is required for palmitoyltransferase activity (By similarity)
    Similarity: Belongs to the DHHC palmitoyltransferase family
    Similarity: Contains 1 DHHC-type zinc finger


    ZDHHC24 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZDH24_HUMAN, Q6UX98
    Catalytic activity: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA

         Enzyme Number (IUBMB): EC 2.3.1.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
    GO:0016746transferase activity, transferring acyl groups IEA--
         
    ZDHHC24 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZDHHC24:
     Increased G1 DNA content 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Zdhhc24):
     normal 

    ZDHHC24 for phenotypes           About GeneDecksing

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZDHHC24

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZDHHC24 (ZDH24)

    Search CenterWatch for drugs/clinical trials and news about ZDHHC24 / ZDH24

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZDHHC24 gene: 
    NM_207340.1  

    Unigene Cluster for ZDHHC24:

    Zinc finger, DHHC-type containing 24
    Hs.659933  [show with all ESTs]
    Unigene Representative Sequence: AK022244
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000534073 ENST00000526986(uc009yrg.2) ENST00000310442(uc001oin.1)
    ENST00000525925
    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ZDHHC24:
    hsa-miR-149 hsa-miR-490-3p
    SwitchGear 3'UTR luciferase reporter plasmidZDHHC24 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK022244.1 AK301787.1 AK310561.1 AY358448.1 BC005015.1 BC057833.1 

    8 DOTS entries:

    DT.100772249  DT.100672674  DT.100031280  DT.203214  DT.91745610  DT.100839104  DT.100760154  DT.100838305 

    24/107 AceView cDNA sequences (see all 107):

    AK022244 BC005015 BM923817 CR616301 CA425934 CK905601 BE910102 BM702244 
    BU633237 BC057833 BQ222156 BE904570 BQ064953 BG113193 CR623920 BM664925 
    BM894080 AW006720 BI916652 CD518858 CA398129 BM791695 AI805053 BU632065 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC24    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b
    SP1:                          -               
    SP2:                          -               
    SP3:                                          


    ECgene alternative splicing isoforms for ZDHHC24

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZDHHC24 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGTGGGCT
    ZDHHC24 Expression
    About this image


    See ZDHHC24 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZDHHC24

    SOURCE GeneReport for Unigene cluster: Hs.659933
        SABiosciences Custom PCR Arrays for ZDHHC24
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC24

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZDHHC24 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zdhhc241 , 5 zinc finger, DHHC domain containing 241, 5 84.15(n)1
    87.68(a)1
      19 (4.13 cM)5
    706051  NM_027476.31  NP_081752.21 
     48786685 
    lizard
    (Anolis carolinensis)
    Reptilia ZDHHC246
    Uncharacterized protein
    47(a)
    1 ↔ 1
    GL343832.1(81620-87257)
    zebrafish
    (Danio rerio)
    Actinopterygii zdhhc241 zinc finger, DHHC-type containing 24 53.67(n)
    45.85(a)
      436596  NM_001002324.1  NP_001002324.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG46761 CG4676 46.32(n)
    33.77(a)
      36465  NM_137009.2  NP_610853.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dhhc-11 Protein DHHC-1 39.95(n)
    28.57(a)
      181606  NM_078109.3  NP_510510.1 


    ENSEMBL Gene Tree for ZDHHC24 (if available)
    TreeFam Gene Tree for ZDHHC24 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/142 SNPs in ZDHHC24 are shown (see all 142)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs286878881,2
    C,F--66306301(+) TTCTTT/CACCTT 1 -- int13Minor allele frequency- C:0.10WA CSA 122
    rs37375251,2
    C,F,H--66306355(-) TGTGCT/CTTTGC 1 -- int117Minor allele frequency- C:0.13EA NS NA 3892
    rs1871585551,2
    --66306462(+) AGAGAA/GGTTCC 1 -- int10--------
    rs115520451,2
    C,F--66306568(+) CTTGGC/TGTGCT 1 -- int12Minor allele frequency- T:0.00NA 4
    rs1435719741,2
    --66306650(+) CAGTTG/TCCAGG 1 -- int10--------
    rs1472924651,2
    --66306862(+) TAGGCA/GGGCAG 1 -- ut310--------
    rs31800631,2
    C,H--66306905(-) AACATC/TTGCAT 1 -- ut314Minor allele frequency- T:0.00MN NS NA 368
    rs1998731691,2
    C--66306970(+) CCTTCC/TTCCCT 1 -- ut310--------
    rs1411120141,2
    C,F--66307174(+) TCCCAT/CGTGGT 2 /T syn12Minor allele frequency- C:0.00NA EU 4441
    rs1498668501,2
    C,F--66307201(+) AGCATC/TCCATG 2 G syn11Minor allele frequency- T:0.00NA 4228

    HapMap Linkage Disequilibrium report for ZDHHC24 (66288108 - 66313709 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZDHHC24:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv897787CNV Loss21882294
    nsv522277CNV Loss19592680
    dgv1187n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZDHHC24 for disorders           About MalaCards

    ZDHHC24 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZDHHC24
    Human Genome Epidemiology (HuGE) Navigator: ZDHHC24 (3 documents)

    Export disorders for ZDHHC24 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZDHHC24 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZDHHC24)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. Large-scale genome-wide association analysis of bipol ar disorder identifies a new susceptibility locus near ODZ4. (PubMed id 21926972)1 Sklar P....Purcell S.M. (2011)
    5. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 254359 HGNC: 27387 AceView: LOC254359 Ensembl:ENSG00000174165 euGenes: HUgn254359
    ECgene: ZDHHC24 H-InvDB: ZDHHC24

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZDHHC24 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZDHHC24 gene:
    Search GeneIP for patents involving ZDHHC24

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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