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Aliases for ZDHHC24 Gene

Aliases for ZDHHC24 Gene

  • Zinc Finger, DHHC-Type Containing 24 2 3
  • Zinc Finger DHHC Domain-Containing Protein 24 3 4
  • DHHC-24 3 4
  • Zinc Finger, DHHC Domain Containing 24 3
  • EC 2.3.1.225 4

External Ids for ZDHHC24 Gene

Previous GeneCards Identifiers for ZDHHC24 Gene

  • GC11M066064
  • GC11M066306
  • GC11M062638
  • GC11M066288

Summaries for ZDHHC24 Gene

GeneCards Summary for ZDHHC24 Gene

ZDHHC24 (Zinc Finger, DHHC-Type Containing 24) is a Protein Coding gene. GO annotations related to this gene include protein-cysteine S-palmitoyltransferase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC24 Gene

Genomics for ZDHHC24 Gene

Regulatory Elements for ZDHHC24 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZDHHC24 Gene

Chromosome:
11
Start:
66,520,637 bp from pter
End:
66,546,238 bp from pter
Size:
25,602 bases
Orientation:
Minus strand

Genomic View for ZDHHC24 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for ZDHHC24 Gene

Proteins for ZDHHC24 Gene

  • Protein details for ZDHHC24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UX98-ZDH24_HUMAN
    Recommended name:
    Probable palmitoyltransferase ZDHHC24
    Protein Accession:
    Q6UX98
    Secondary Accessions:
    • Q6PEW7
    • Q9BSJ0

    Protein attributes for ZDHHC24 Gene

    Size:
    284 amino acids
    Molecular mass:
    30176 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZDHHC24 Gene

Proteomics data for ZDHHC24 Gene at MOPED

Post-translational modifications for ZDHHC24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZDHHC24 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZDHHC24 Gene

Domains & Families for ZDHHC24 Gene

Gene Families for ZDHHC24 Gene

Protein Domains for ZDHHC24 Gene

Suggested Antigen Peptide Sequences for ZDHHC24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UX98

UniProtKB/Swiss-Prot:

ZDH24_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
  • Contains 1 DHHC-type zinc finger.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family.
Similarity:
  • Contains 1 DHHC-type zinc finger.
genes like me logo Genes that share domains with ZDHHC24: view

Function for ZDHHC24 Gene

Molecular function for ZDHHC24 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA

Enzyme Numbers (IUBMB) for ZDHHC24 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IBA --
genes like me logo Genes that share ontologies with ZDHHC24: view

Phenotypes for ZDHHC24 Gene

MGI mutant phenotypes for ZDHHC24:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with ZDHHC24: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZDHHC24

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC24 Gene

Localization for ZDHHC24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC24 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZDHHC24 Gene COMPARTMENTS Subcellular localization image for ZDHHC24 gene
Compartment Confidence
cytosol 2

Gene Ontology (GO) - Cellular Components for ZDHHC24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA --
GO:0005794 Golgi apparatus IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC24: view

Pathways & Interactions for ZDHHC24 Gene

SuperPathways for ZDHHC24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006612 protein targeting to membrane IBA --
GO:0008152 metabolic process --
GO:0018230 peptidyl-L-cysteine S-palmitoylation IBA --
genes like me logo Genes that share ontologies with ZDHHC24: view

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC24 Gene

Drugs & Compounds for ZDHHC24 Gene

(1) Drugs for ZDHHC24 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for ZDHHC24 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
genes like me logo Genes that share compounds with ZDHHC24: view

Transcripts for ZDHHC24 Gene

Unigene Clusters for ZDHHC24 Gene

Zinc finger, DHHC-type containing 24:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZDHHC24

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC24 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b
SP1: -
SP2: -
SP3:

Relevant External Links for ZDHHC24 Gene

GeneLoc Exon Structure for
ZDHHC24
ECgene alternative splicing isoforms for
ZDHHC24

Expression for ZDHHC24 Gene

mRNA expression in normal human tissues for ZDHHC24 Gene

Protein differential expression in normal tissues from HIPED for ZDHHC24 Gene

This gene is overexpressed in Placenta (39.6) and CD8 Tcells (29.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZDHHC24 Gene



SOURCE GeneReport for Unigene cluster for ZDHHC24 Gene Hs.659933

genes like me logo Genes that share expression patterns with ZDHHC24: view

Protein tissue co-expression partners for ZDHHC24 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZDHHC24 Gene

Orthologs for ZDHHC24 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZDHHC24 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZDHHC24 35
  • 89.79 (n)
  • 93.31 (a)
ZDHHC24 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZDHHC24 35
  • 91.9 (n)
  • 95.42 (a)
ZDHHC24 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zdhhc24 35
  • 84.15 (n)
  • 87.68 (a)
Zdhhc24 16
Zdhhc24 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC24 35
  • 99.37 (n)
  • 98.84 (a)
ZDHHC24 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zdhhc24 35
  • 84.39 (n)
  • 88.03 (a)
oppossum
(Monodelphis domestica)
Mammalia ZDHHC24 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZDHHC24 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc24 35
  • 50.52 (n)
  • 44.92 (a)
zebrafish
(Danio rerio)
Actinopterygii zdhhc24 35
  • 53.26 (n)
  • 44.93 (a)
zdhhc24 36
  • 38 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009199 35
  • 49.91 (n)
  • 40.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10344 35
  • 46.79 (n)
  • 37.95 (a)
CG10344 36
  • 24 (a)
OneToMany
CG13029 36
  • 24 (a)
OneToMany
CG17195 36
  • 23 (a)
OneToMany
CG17196 36
  • 23 (a)
OneToMany
CG17197 36
  • 21 (a)
OneToMany
CG17198 36
  • 22 (a)
OneToMany
CG18810 36
  • 22 (a)
OneToMany
CG4676 36
  • 27 (a)
OneToMany
CG4956 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dhhc-1 35
  • 42.03 (n)
  • 31.52 (a)
dhhc-1 36
  • 21 (a)
OneToMany
dhhc-10 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
OneToMany
CSA.3283 36
  • 25 (a)
OneToMany
Species with no ortholog for ZDHHC24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC24 Gene

ENSEMBL:
Gene Tree for ZDHHC24 (if available)
TreeFam:
Gene Tree for ZDHHC24 (if available)

Paralogs for ZDHHC24 Gene

No data available for Paralogs for ZDHHC24 Gene

Variants for ZDHHC24 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC24 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs608504 -- 66,542,454(+) ACGGG(C/T)GGTGA intron-variant, utr-variant-3-prime, downstream-variant-500B
rs610293 -- 66,542,909(+) CTTCC(C/T)GAGGC intron-variant, utr-variant-3-prime
rs640213 -- 66,538,385(+) agagc(A/C)aaact intron-variant
rs1189338 -- 66,537,640(+) ACCAT(C/G)CTGGC intron-variant
rs1201433 -- 66,537,803(+) GGCAC(A/C)TGTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC24 Gene

Variant ID Type Subtype PubMed ID
dgv1187n71 CNV Loss 21882294
nsv522277 CNV Loss 19592680
nsv897787 CNV Loss 21882294

Variation tolerance for ZDHHC24 Gene

Residual Variation Intolerance Score: 63.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.71; 86.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZDHHC24 Gene

HapMap Linkage Disequilibrium report
ZDHHC24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC24 Gene

Disorders for ZDHHC24 Gene

Relevant External Links for ZDHHC24

Genetic Association Database (GAD)
ZDHHC24
Human Genome Epidemiology (HuGE) Navigator
ZDHHC24
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZDHHC24
genes like me logo Genes that share disorders with ZDHHC24: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC24 Gene

Publications for ZDHHC24 Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  2. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) (Nat. Genet. 2011) 67
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 67
  4. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for ZDHHC24 Gene

Sources for ZDHHC24 Gene

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