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Aliases for ZDHHC23 Gene

Aliases for ZDHHC23 Gene

  • Zinc Finger, DHHC-Type Containing 23 2 3
  • Zinc Finger DHHC Domain-Containing Protein 23 3 4
  • DHHC-23 3 4
  • Zinc Finger, DHHC Domain Containing 23 3
  • Probable Palmitoyltransferase ZDHHC23 3
  • Palmitoyltransferase ZDHHC23 3
  • EC 2.3.1.225 4
  • ZDHHC23 4
  • NIDD 3

External Ids for ZDHHC23 Gene

Summaries for ZDHHC23 Gene

GeneCards Summary for ZDHHC23 Gene

ZDHHC23 (Zinc Finger, DHHC-Type Containing 23) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring acyl groups.

UniProtKB/Swiss-Prot for ZDHHC23 Gene

  • Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC23 Gene

Genomics for ZDHHC23 Gene

Genomic Location for ZDHHC23 Gene

Start:
113,947,901 bp from pter
End:
113,986,859 bp from pter
Size:
38,959 bases
Orientation:
Plus strand

Genomic View for ZDHHC23 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZDHHC23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC23 Gene

Regulatory Elements for ZDHHC23 Gene

Proteins for ZDHHC23 Gene

  • Protein details for ZDHHC23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYP9-ZDH23_HUMAN
    Recommended name:
    Palmitoyltransferase ZDHHC23
    Protein Accession:
    Q8IYP9
    Secondary Accessions:
    • D3DN76

    Protein attributes for ZDHHC23 Gene

    Size:
    409 amino acids
    Molecular mass:
    45983 Da
    Quaternary structure:
    • Interacts with NOS1.

neXtProt entry for ZDHHC23 Gene

Proteomics data for ZDHHC23 Gene at MOPED

Post-translational modifications for ZDHHC23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZDHHC23 Gene

No data available for DME Specific Peptides for ZDHHC23 Gene

Domains for ZDHHC23 Gene

Gene Families for ZDHHC23 Gene

HGNC:
  • ZDHHC :Zinc fingers, DHHC-type

Protein Domains for ZDHHC23 Gene

UniProtKB/Swiss-Prot:

ZDH23_HUMAN
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.:
    • Q8IYP9
Family:
  • Belongs to the DHHC palmitoyltransferase family.:
    • Q8IYP9
Similarity:
  • Contains 1 DHHC-type zinc finger.:
    • Q8IYP9
genes like me logo Genes that share domains with ZDHHC23: view

Function for ZDHHC23 Gene

Molecular function for ZDHHC23 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
UniProtKB/Swiss-Prot Function: Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane.

Enzyme Numbers (IUBMB) for ZDHHC23 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC23: view

miRNA for ZDHHC23 Gene

miRTarBase miRNAs that target ZDHHC23

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZDHHC23 Gene

Localization for ZDHHC23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC23 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZDHHC23 Gene COMPARTMENTS Subcellular localization image for ZDHHC23 gene
Compartment Confidence
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZDHHC23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC23: view

Pathways for ZDHHC23 Gene

SuperPathways for ZDHHC23 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0018345 protein palmitoylation IEA --
GO:0072659 protein localization to plasma membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC23: view

No data available for Pathways by source for ZDHHC23 Gene

Transcripts for ZDHHC23 Gene

Unigene Clusters for ZDHHC23 Gene

Zinc finger, DHHC-type containing 23:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC23 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4:

Relevant External Links for ZDHHC23 Gene

GeneLoc Exon Structure for
ZDHHC23
ECgene alternative splicing isoforms for
ZDHHC23

Expression for ZDHHC23 Gene

mRNA expression in normal human tissues for ZDHHC23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZDHHC23 Gene

SOURCE GeneReport for Unigene cluster for ZDHHC23 Gene Hs.21902

genes like me logo Genes that share expressions with ZDHHC23: view

Orthologs for ZDHHC23 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC23 36
  • 99.67 (n)
  • 99.76 (a)
ZDHHC23 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZDHHC23 36
  • 88.5 (n)
  • 89.25 (a)
ZDHHC23 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZDHHC23 36
  • 85.85 (n)
  • 85.68 (a)
ZDHHC23 37
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zdhhc23 36
  • 87.29 (n)
  • 90.91 (a)
Zdhhc23 16
Zdhhc23 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZDHHC23 37
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC23 37
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zdhhc23 36
  • 86.33 (n)
  • 90.5 (a)
chicken
(Gallus gallus)
Aves ZDHHC23 36
  • 69.75 (n)
  • 68.78 (a)
ZDHHC23 37
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZDHHC23 37
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc23 36
  • 62.08 (n)
  • 57.66 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12585 36
zebrafish
(Danio rerio)
Actinopterygii zdhhc23a 37
  • 47 (a)
OneToMany
zdhhc23b 36
  • 57.12 (n)
  • 50.64 (a)
zdhhc23b 37
  • 47 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008264 36
  • 44.14 (n)
  • 32.09 (a)
fruit fly
(Drosophila melanogaster)
Insecta GABPI 36
  • 43.63 (n)
  • 30.62 (a)
GABPI 37
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWF1 37
  • 17 (a)
OneToOne
Species with no ortholog for ZDHHC23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZDHHC23 Gene

ENSEMBL:
Gene Tree for ZDHHC23 (if available)
TreeFam:
Gene Tree for ZDHHC23 (if available)

Paralogs for ZDHHC23 Gene

Selected SIMAP similar genes for ZDHHC23 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZDHHC23: view

No data available for Paralogs for ZDHHC23 Gene

Variants for ZDHHC23 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC23 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs722927 -- 113,962,328(+) GCTGG(C/G)ACTAA utr-variant-3-prime, intron-variant, nc-transcript-variant
rs1386478 -- 113,962,104(+) GAGGC(A/G)CCTGT utr-variant-3-prime, intron-variant, nc-transcript-variant
rs1487267 -- 113,948,339(+) GGAGC(A/C)TGGTG intron-variant, upstream-variant-2KB
rs1487268 -- 113,963,360(+) GCTAA(A/G)GTAGA downstream-variant-500B, utr-variant-3-prime, intron-variant, nc-transcript-variant
rs2046580 -- 113,963,450(+) TTAAA(A/G)AAAAC downstream-variant-500B, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC23 Gene

Variant ID Type Subtype PubMed ID
esv25178 CNV Loss 19812545

Relevant External Links for ZDHHC23 Gene

HapMap Linkage Disequilibrium report
ZDHHC23

Disorders for ZDHHC23 Gene

(1) University of Copenhagen DISEASES for ZDHHC23 Gene

genes like me logo Genes that share disorders with ZDHHC23: view

No data available for UniProtKB/Swiss-Prot for ZDHHC23 Gene

Publications for ZDHHC23 Gene

  1. Distinct acyl protein transferases and thioesterases control surface expression of calcium-activated potassium channels. (PMID: 22399288) Tian L. … Shipston M.J. (J. Biol. Chem. 2012) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  4. Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci. (PMID: 22482804) Ellinghaus D. … Franke A. (Am. J. Hum. Genet. 2012) 3
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4

Products for ZDHHC23 Gene

Sources for ZDHHC23 Gene

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