ZDHHC23 Gene
protein-coding GIFtS: 46
GCID: GC03P113666
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|
zinc finger, DHHC-type containing 23
| |
Aliases
for ZDHHC23 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger, DHHC-Type Containing 231 2 | | NIDD2 | | Zinc Finger DHHC Domain-Containing Protein 232 3 | | Probable Palmitoyltransferase ZDHHC232 | | DHHC-232 3 | | Zinc Finger, DHHC Domain Containing 232 | | MGC425301 | | EC 2.3.1.-3 |
Export aliases for ZDHHC23 gene to outside databasesPrevious GC identifers: GC03P114988 GC03P115149 GC03P111040 |
Summaries
for ZDHHC23 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZDH23_HUMAN, Q8IYP9Function: May be involved in NOS1 regulation and targeting to the synaptic membrane (By similarity)
|
Genomic Views
for ZDHHC23 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZDHHC23 gene promoter:
C/EBPbeta p300 MyoD POU3F2 YY1 Evi-1 Egr-4 Egr-2 Zic1 MRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZDHHC23
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZDHHC23 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q13.31 Ensembl cytogenetic band: 3q13.31 HGNC cytogenetic band: 3q13.31ZDHHC23 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P113666: view genomic region
(about GC identifiers)
Start:
|
113,666,748 bp from pter |
End:
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113,684,248 bp from pter |
Size:
|
17,501 bases |
Orientation:
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plus strand |
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Proteins
for ZDHHC23 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZDH23_HUMAN, Q8IYP9 (See
protein sequence)Recommended Name: Probable palmitoyltransferase ZDHHC23 Size: 409 amino acids; 45983 Da
Subunit: Interacts with NOS1 (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: D3DN76Explore the universe of human proteins at neXtProt for ZDHHC23: NX_Q8IYP9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IYP9
ZDHHC23 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_775841.2
ENSEMBL proteins: ENSP00000330485 ENSP00000417840 ENSP00000420251 ENSP00000420292 ENSP00000417579
Human Recombinant Protein Products for ZDHHC23:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
ZDHHC23 for ontologies About GeneDecksing
ZDHHC23 Antibody Products:
Assay Products for ZDHHC23: |
Protein
Domains /
Families
for ZDHHC23 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZDHHC23 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8IYP9ProtoNet protein and cluster: Q8IYP9 1 Blocks protein family: IPB001594 Zn-finger
UniProtKB/Swiss-Prot: ZDH23_HUMAN, Q8IYP9Domain: The DHHC domain is required for palmitoyltransferase activity (By similarity)Similarity: Belongs to the DHHC palmitoyltransferase familySimilarity: Contains 1 DHHC-type zinc finger |
Function
for ZDHHC23 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZDH23_HUMAN, Q8IYP9Function: May be involved in NOS1 regulation and targeting to the synaptic membrane (By similarity)Catalytic activity: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA Enzyme Number (IUBMB): EC 2.3.1.-1
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- | | GO:0016740 | transferase activity |
-- | -- | | GO:0016746 | transferase activity, transferring acyl groups |
IEA | -- |
ZDHHC23 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC23 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC23
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC23 |
|
Pathways & Interactions
for ZDHHC23 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZDHHC23
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ZDHHC23 (Q8IYP93 ENSP000003304854) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for ZDHHC23 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZDHHC23
Search CenterWatch for drugs/clinical trials and news about ZDHHC23 / ZDH23
|
Transcripts
for ZDHHC23 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZDHHC23 gene: NM_173570.3 Unigene Cluster for ZDHHC23: Zinc finger, DHHC-type containing 23 Hs.21902 [show with all ESTs]Unigene Representative Sequence: AK1272606 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000330212(uc003eau.3 uc003eav.3) ENST00000498275 ENST00000478793
ENST00000491556 ENST00000488129(uc003eaw.1) ENST00000496083
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC23 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC23
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZDHHC23 (NM_173570) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZDHHC23 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZDHHC23 |
Additional cDNA sequence: AF131818.1 AK022842.1 AK127025.1 AK127260.1 AK127996.1 BC035230.1 5 DOTS entries: DT.95349357 DT.100028103 DT.99992085 DT.95110597 DT.120867158 24/69 AceView cDNA sequences (see all 69): AI207975 BU618853 BQ425714 BU607697 AI824803 AA813226 AW271809 BM908262 Z38410 CA389627 BF594840 NM_173570 AW003367 AI023877 AK127996 AI207184 AF131818 AA765840 AI830994 AW151597 BI601234 BI553799 AA580940 AI768537
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC23 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c |
|---|
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| SP1: | | | - | | - | | | | | | | | | | - | | | | - | | - | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | - | | | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | - | | | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZDHHC23
|
Expression
for ZDHHC23 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZDHHC23 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAATTTTAC
About this image
See ZDHHC23 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZDHHC23
SOURCE GeneReport for Unigene cluster: Hs.21902
SABiosciences Custom PCR Arrays for ZDHHC23
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZDHHC23
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZDHHC23 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZDHHC23 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZDHHC23 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC23 |
Orthologs
for ZDHHC23 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZDHHC23 gene from 5/21 species (see all 21) About this table
ENSEMBL Gene Tree for ZDHHC23 (if available)
TreeFam Gene Tree for ZDHHC23 (if available) |
Paralogs
for ZDHHC23 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZDHHC23 gene
- ZDHHC212 ZDHHC32 ZDHHC72 ZDHHC202 ZDHHC152 ZDHHC22
1 SIMAP similar gene for ZDHHC23 using alignment to 5 protein entries: ZDH23_HUMAN (see all proteins):ZDHHC3
ZDHHC23 for paralogs About GeneDecksing
|
Genomic Variants
for ZDHHC23 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZDHHC23 (113666748 - 113684248 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZDHHC23
1 CNV: 63557 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZDHHC23 |
|
Disorders
/ Diseases
for ZDHHC23 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZDHHC23 for disorders About GeneDecksing
3  diseases for ZDHHC23: About MalaCardshyperglycemia malaria neuronitis
1 disease from the University of Copenhagen DISEASES database for ZDHHC23:Diabetes mellitus Export disorders for ZDHHC23 gene to outside databases
|
Publications
for ZDHHC23 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZDHHC23 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZDHHC23) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Combined analysis of genome-wide association studies f or Crohn disease and psoriasis identifies seven shared susceptibility loci. (PubMed id 22482804)1 Ellinghaus D....Franke A. (2012)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- NIDD, a novel DHHC-containing protein, targets neuronal nitric-oxide synthase (nNOS) to the synaptic membrane through a PDZ-dependent interaction and regulates nNOS activity. (PubMed id 15105416)1 Saitoh F....Suzuki T. (2004)
- Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (1997)
- A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1 Andersson B.... Gibbs R.A. (1996)
|
External Searches for ZDHHC23 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZDHHC23 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZDHHC23 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZDHHC23 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZDHHC23 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZDHHC23 gene:
Search GeneIP for patents involving ZDHHC23
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZDHHC23 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC23 |
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