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Aliases for ZDHHC23 Gene

Aliases for ZDHHC23 Gene

  • Zinc Finger DHHC-Type Containing 23 2 3 5
  • Zinc Finger DHHC Domain-Containing Protein 23 3 4
  • DHHC-23 3 4
  • Palmitoyltransferase ZDHHC23 3
  • EC 2.3.1.225 4
  • ZDHHC23 4
  • NIDD 3

External Ids for ZDHHC23 Gene

Previous GeneCards Identifiers for ZDHHC23 Gene

  • GC03P114988
  • GC03P115149
  • GC03P113666
  • GC03P111040

Summaries for ZDHHC23 Gene

GeneCards Summary for ZDHHC23 Gene

ZDHHC23 (Zinc Finger DHHC-Type Containing 23) is a Protein Coding gene. GO annotations related to this gene include protein-cysteine S-palmitoyltransferase activity. An important paralog of this gene is ZDHHC2.

UniProtKB/Swiss-Prot for ZDHHC23 Gene

  • Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC23 Gene

Genomics for ZDHHC23 Gene

Regulatory Elements for ZDHHC23 Gene

Enhancers for ZDHHC23 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G113146 1.7 FANTOM5 Ensembl ENCODE dbSUPER 4.7 -798.1 -798112 7.3 PKNOX1 INSM2 FEZF1 ZNF366 ZNF391 TSHZ1 ZNF488 ZEB2 ZNF843 ZNF518A LINC02044 BOC ZDHHC23 CD200R1 ENSG00000241219
GH03G113210 1.2 ENCODE dbSUPER 5.2 -735.7 -735699 4.1 HDGF PKNOX1 ARNT ZSCAN4 ZNF133 ZNF76 KLF17 SIN3A ZNF2 GLIS2 LINC02044 BOC ZDHHC23 GC03M113216
GH03G113116 0.8 Ensembl ENCODE 6 -829.6 -829645 2.5 SREBF1 JUND POLR2A JUN ATF2 LINC02044 ZDHHC23 ENSG00000241219
GH03G114427 0.9 FANTOM5 ENCODE 3 +480.3 480254 1.5 SP1 CTCF JUNB CREM GABPA SPI1 ZDHHC23 ZBTB20 GC03P114421 ZBTB20-AS5
GH03G113985 0.5 FANTOM5 4.7 +37.8 37820 0.3 EBF1 CCDC191 QTRT2 ZDHHC23 SIDT1 USF3 LOC100127892 LOC105374048
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZDHHC23 on UCSC Golden Path with GeneCards custom track

Promoters for ZDHHC23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000156741 0 1800 ZNF76 SIN3A DMAP1 BMI1 GLIS2 EGR1 SCRT2 EGR2 SP3 ZEB2

Genomic Location for ZDHHC23 Gene

Chromosome:
3
Start:
113,947,901 bp from pter
End:
113,992,167 bp from pter
Size:
44,267 bases
Orientation:
Plus strand

Genomic View for ZDHHC23 Gene

Genes around ZDHHC23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC23 Gene

Proteins for ZDHHC23 Gene

  • Protein details for ZDHHC23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYP9-ZDH23_HUMAN
    Recommended name:
    Palmitoyltransferase ZDHHC23
    Protein Accession:
    Q8IYP9
    Secondary Accessions:
    • D3DN76

    Protein attributes for ZDHHC23 Gene

    Size:
    409 amino acids
    Molecular mass:
    45983 Da
    Quaternary structure:
    • Interacts with NOS1.

neXtProt entry for ZDHHC23 Gene

Post-translational modifications for ZDHHC23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZDHHC23 Gene

Domains & Families for ZDHHC23 Gene

Gene Families for ZDHHC23 Gene

Protein Domains for ZDHHC23 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IYP9

UniProtKB/Swiss-Prot:

ZDH23_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family.
genes like me logo Genes that share domains with ZDHHC23: view

Function for ZDHHC23 Gene

Molecular function for ZDHHC23 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
UniProtKB/Swiss-Prot Function:
Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane.

Enzyme Numbers (IUBMB) for ZDHHC23 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC23: view

Phenotypes for ZDHHC23 Gene

genes like me logo Genes that share phenotypes with ZDHHC23: view

Animal Models for ZDHHC23 Gene

MGI Knock Outs for ZDHHC23:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZDHHC23 Gene

Localization for ZDHHC23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC23 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC23 gene
Compartment Confidence
nucleus 2
plasma membrane 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ZDHHC23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC23: view

Pathways & Interactions for ZDHHC23 Gene

SuperPathways for ZDHHC23 Gene

No Data Available

Interacting Proteins for ZDHHC23 Gene

Gene Ontology (GO) - Biological Process for ZDHHC23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018345 protein palmitoylation IEA --
GO:0072659 protein localization to plasma membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC23: view

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC23 Gene

Drugs & Compounds for ZDHHC23 Gene

(1) Drugs for ZDHHC23 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for ZDHHC23 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
genes like me logo Genes that share compounds with ZDHHC23: view

Transcripts for ZDHHC23 Gene

Unigene Clusters for ZDHHC23 Gene

Zinc finger, DHHC-type containing 23:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC23 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4:

Relevant External Links for ZDHHC23 Gene

GeneLoc Exon Structure for
ZDHHC23
ECgene alternative splicing isoforms for
ZDHHC23

Expression for ZDHHC23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZDHHC23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZDHHC23 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZDHHC23 Gene



Protein tissue co-expression partners for ZDHHC23 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZDHHC23 Gene:

ZDHHC23

SOURCE GeneReport for Unigene cluster for ZDHHC23 Gene:

Hs.21902

Evidence on tissue expression from TISSUES for ZDHHC23 Gene

  • Nervous system(2)
genes like me logo Genes that share expression patterns with ZDHHC23: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC23 Gene

Orthologs for ZDHHC23 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC23 34 35
  • 99.67 (n)
cow
(Bos Taurus)
Mammalia ZDHHC23 34 35
  • 88.5 (n)
mouse
(Mus musculus)
Mammalia Zdhhc23 34 16 35
  • 87.29 (n)
rat
(Rattus norvegicus)
Mammalia Zdhhc23 34
  • 86.33 (n)
dog
(Canis familiaris)
Mammalia ZDHHC23 34 35
  • 85.85 (n)
oppossum
(Monodelphis domestica)
Mammalia ZDHHC23 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC23 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZDHHC23 34 35
  • 69.75 (n)
lizard
(Anolis carolinensis)
Reptilia ZDHHC23 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc23 34
  • 62.08 (n)
zebrafish
(Danio rerio)
Actinopterygii zdhhc23b 34 35
  • 57.12 (n)
zdhhc23a 35
  • 47 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12585 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008264 34
  • 44.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta GABPI 34 35
  • 43.63 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWF1 35
  • 17 (a)
OneToOne
Species where no ortholog for ZDHHC23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZDHHC23 Gene

ENSEMBL:
Gene Tree for ZDHHC23 (if available)
TreeFam:
Gene Tree for ZDHHC23 (if available)

Paralogs for ZDHHC23 Gene

Paralogs for ZDHHC23 Gene

(1) SIMAP similar genes for ZDHHC23 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZDHHC23: view

Variants for ZDHHC23 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC23 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000031383 -- 113,985,480(+) AAGGG(A/G)AAAAG intron-variant
rs1000045219 -- 113,951,187(+) CCACA(C/G)CTCCA intron-variant
rs1000134358 -- 113,991,582(+) ATACT(C/G)AATGC intron-variant
rs1000254664 -- 113,969,931(+) AATTG(C/T)TTTGG intron-variant
rs1000366526 -- 113,962,545(+) AACTA(A/C)AATTC intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC23 Gene

Variant ID Type Subtype PubMed ID
dgv8509n54 CNV gain 21841781
dgv8510n54 CNV loss 21841781
dgv8511n54 CNV gain+loss 21841781
esv25178 CNV loss 19812545
nsv1013506 CNV gain 25217958
nsv591312 CNV gain+loss 21841781
nsv591322 CNV gain 21841781
nsv591324 CNV loss 21841781
nsv591325 CNV loss 21841781
nsv591326 CNV gain 21841781

Variation tolerance for ZDHHC23 Gene

Residual Variation Intolerance Score: 24.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.01; 37.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZDHHC23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZDHHC23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC23 Gene

Disorders for ZDHHC23 Gene

Relevant External Links for ZDHHC23

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZDHHC23

No disorders were found for ZDHHC23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC23 Gene

Publications for ZDHHC23 Gene

  1. Distinct acyl protein transferases and thioesterases control surface expression of calcium-activated potassium channels. (PMID: 22399288) Tian L. … Shipston M.J. (J. Biol. Chem. 2012) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci. (PMID: 22482804) Ellinghaus D. … Franke A. (Am. J. Hum. Genet. 2012) 3 64
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4 64

Products for ZDHHC23 Gene

Sources for ZDHHC23 Gene

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