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Aliases for ZDHHC23 Gene

Aliases for ZDHHC23 Gene

  • Zinc Finger DHHC-Type Containing 23 2 3
  • Zinc Finger DHHC Domain-Containing Protein 23 3 4
  • DHHC-23 3 4
  • Zinc Finger, DHHC-Type Containing 23 5
  • EC 2.3.1.225 4
  • ZDHHC23 4
  • NIDD 3

External Ids for ZDHHC23 Gene

Previous GeneCards Identifiers for ZDHHC23 Gene

  • GC03P114988
  • GC03P115149
  • GC03P113666
  • GC03P111040

Summaries for ZDHHC23 Gene

GeneCards Summary for ZDHHC23 Gene

ZDHHC23 (Zinc Finger DHHC-Type Containing 23) is a Protein Coding gene. GO annotations related to this gene include protein-cysteine S-palmitoyltransferase activity. An important paralog of this gene is ZDHHC18.

UniProtKB/Swiss-Prot for ZDHHC23 Gene

  • Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC23 Gene

Genomics for ZDHHC23 Gene

Regulatory Elements for ZDHHC23 Gene

Promoters for ZDHHC23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZDHHC23 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZDHHC23 Gene

Chromosome:
3
Start:
113,947,901 bp from pter
End:
113,992,167 bp from pter
Size:
44,267 bases
Orientation:
Plus strand

Genomic View for ZDHHC23 Gene

Genes around ZDHHC23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC23 Gene

Proteins for ZDHHC23 Gene

  • Protein details for ZDHHC23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYP9-ZDH23_HUMAN
    Recommended name:
    Palmitoyltransferase ZDHHC23
    Protein Accession:
    Q8IYP9
    Secondary Accessions:
    • D3DN76

    Protein attributes for ZDHHC23 Gene

    Size:
    409 amino acids
    Molecular mass:
    45983 Da
    Quaternary structure:
    • Interacts with NOS1.

neXtProt entry for ZDHHC23 Gene

Proteomics data for ZDHHC23 Gene at MOPED

Post-translational modifications for ZDHHC23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZDHHC23 Gene

No data available for DME Specific Peptides for ZDHHC23 Gene

Domains & Families for ZDHHC23 Gene

Gene Families for ZDHHC23 Gene

Protein Domains for ZDHHC23 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IYP9

UniProtKB/Swiss-Prot:

ZDH23_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
  • Contains 1 DHHC-type zinc finger.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family.
Similarity:
  • Contains 1 DHHC-type zinc finger.
genes like me logo Genes that share domains with ZDHHC23: view

Function for ZDHHC23 Gene

Molecular function for ZDHHC23 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
UniProtKB/Swiss-Prot Function:
Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane.

Enzyme Numbers (IUBMB) for ZDHHC23 Gene

Phenotypes for ZDHHC23 Gene

genes like me logo Genes that share phenotypes with ZDHHC23: view

Animal Models for ZDHHC23 Gene

MGI Knock Outs for ZDHHC23:

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZDHHC23 Gene

Localization for ZDHHC23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC23 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZDHHC23 Gene COMPARTMENTS Subcellular localization image for ZDHHC23 gene
Compartment Confidence
nucleus 2
cytosol 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for ZDHHC23 Gene

Pathways & Interactions for ZDHHC23 Gene

SuperPathways for ZDHHC23 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0072659 protein localization to plasma membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC23: view

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC23 Gene

Drugs & Compounds for ZDHHC23 Gene

(1) Drugs for ZDHHC23 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for ZDHHC23 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
genes like me logo Genes that share compounds with ZDHHC23: view

Transcripts for ZDHHC23 Gene

Unigene Clusters for ZDHHC23 Gene

Zinc finger, DHHC-type containing 23:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC23 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4:

Relevant External Links for ZDHHC23 Gene

GeneLoc Exon Structure for
ZDHHC23
ECgene alternative splicing isoforms for
ZDHHC23

Expression for ZDHHC23 Gene

mRNA expression in normal human tissues for ZDHHC23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZDHHC23 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZDHHC23 Gene



SOURCE GeneReport for Unigene cluster for ZDHHC23 Gene Hs.21902

genes like me logo Genes that share expression patterns with ZDHHC23: view

Protein tissue co-expression partners for ZDHHC23 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZDHHC23 Gene

Orthologs for ZDHHC23 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC23 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZDHHC23 35
  • 88.5 (n)
  • 89.25 (a)
ZDHHC23 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZDHHC23 35
  • 85.85 (n)
  • 85.68 (a)
ZDHHC23 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zdhhc23 35
  • 87.29 (n)
  • 90.91 (a)
Zdhhc23 16
Zdhhc23 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC23 35
  • 99.67 (n)
  • 99.76 (a)
ZDHHC23 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zdhhc23 35
  • 86.33 (n)
  • 90.5 (a)
oppossum
(Monodelphis domestica)
Mammalia ZDHHC23 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC23 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZDHHC23 35
  • 69.75 (n)
  • 68.78 (a)
ZDHHC23 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZDHHC23 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc23 35
  • 62.08 (n)
  • 57.66 (a)
zebrafish
(Danio rerio)
Actinopterygii zdhhc23b 35
  • 57.12 (n)
  • 50.64 (a)
zdhhc23a 36
  • 47 (a)
OneToMany
zdhhc23b 36
  • 47 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12585 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008264 35
  • 44.14 (n)
  • 32.09 (a)
fruit fly
(Drosophila melanogaster)
Insecta GABPI 35
  • 43.63 (n)
  • 30.62 (a)
GABPI 36
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWF1 36
  • 17 (a)
OneToOne
Species with no ortholog for ZDHHC23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZDHHC23 Gene

ENSEMBL:
Gene Tree for ZDHHC23 (if available)
TreeFam:
Gene Tree for ZDHHC23 (if available)

Paralogs for ZDHHC23 Gene

Paralogs for ZDHHC23 Gene

(1) SIMAP similar genes for ZDHHC23 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZDHHC23: view

Variants for ZDHHC23 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC23 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs17853401 - 113,953,932(+) TCACT(A/C)ACAGA intron-variant, nc-transcript-variant, reference, missense
rs17853402 - 113,954,199(+) AGAAG(A/G)CCAAA nc-transcript-variant, reference, missense
rs11921691 - 113,954,278(+) TTCCA(A/G)GATGC nc-transcript-variant, reference, missense
rs17857054 - 113,954,359(+) ATGGC(A/G)CTGCC nc-transcript-variant, reference, missense
rs722927 -- 113,962,328(+) GCTGG(C/G)ACTAA intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC23 Gene

Variant ID Type Subtype PubMed ID
esv25178 CNV Loss 19812545

Variation tolerance for ZDHHC23 Gene

Residual Variation Intolerance Score: 24.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.01; 37.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZDHHC23 Gene

HapMap Linkage Disequilibrium report
ZDHHC23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC23 Gene

Disorders for ZDHHC23 Gene

Relevant External Links for ZDHHC23

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZDHHC23

No disorders were found for ZDHHC23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC23 Gene

Publications for ZDHHC23 Gene

  1. Distinct acyl protein transferases and thioesterases control surface expression of calcium-activated potassium channels. (PMID: 22399288) Tian L. … Shipston M.J. (J. Biol. Chem. 2012) 2 3 4 67
  2. Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci. (PMID: 22482804) Ellinghaus D. … Franke A. (Am. J. Hum. Genet. 2012) 3
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. NIDD, a novel DHHC-containing protein, targets neuronal nitric-oxide synthase (nNOS) to the synaptic membrane through a PDZ-dependent interaction and regulates nNOS activity. (PMID: 15105416) Saitoh F. … Suzuki T. (J. Biol. Chem. 2004) 3

Products for ZDHHC23 Gene

Sources for ZDHHC23 Gene

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