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Aliases for ZDHHC22 Gene

Aliases for ZDHHC22 Gene

  • Zinc Finger DHHC-Type Containing 22 2 3 5
  • Zinc Finger DHHC Domain-Containing Protein 22 3 4
  • C14orf59 3 4
  • DHHC-22 3 4
  • Zinc Finger, DHHC Domain Containing 22 3
  • Putative Palmitoyltransferase ZDHHC22 3
  • Chromosome 14 Open Reading Frame 59 2
  • Palmitoyltransferase ZDHHC22 3
  • EC 4
  • ZDHHC22 4

External Ids for ZDHHC22 Gene

Previous HGNC Symbols for ZDHHC22 Gene

  • C14orf59

Previous GeneCards Identifiers for ZDHHC22 Gene

  • GC14M075588
  • GC14M076667
  • GC14M077597
  • GC14M057765

Summaries for ZDHHC22 Gene

GeneCards Summary for ZDHHC22 Gene

ZDHHC22 (Zinc Finger DHHC-Type Containing 22) is a Protein Coding gene. GO annotations related to this gene include protein-cysteine S-palmitoyltransferase activity.

UniProtKB/Swiss-Prot for ZDHHC22 Gene

  • Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane.

Additional gene information for ZDHHC22 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC22 Gene

Genomics for ZDHHC22 Gene

Regulatory Elements for ZDHHC22 Gene

Enhancers for ZDHHC22 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H077312 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11 -171.2 -171204 5.7 TBP PKNOX1 NFIB INSM2 ARID4B SIN3A ZNF2 RAD21 ZNF143 RCOR1 TMED8 GSTZ1 NGB ZDHHC22 ENSG00000201384 SAMD15 VIPAS39 AHSA1 TMEM63C POMT2
GH14H077301 1.5 Ensembl ENCODE dbSUPER 11 -160.8 -160816 6.5 PKNOX1 FOXA2 ATF1 ARID4B SIN3A FEZF1 ZNF2 ZNF207 ATF7 FOS VIPAS39 IRF2BPL GSTZ1 ALKBH1 NGB MIR1260A ZDHHC22 ENSG00000201384 SAMD15 TMED8
GH14H077181 1.1 ENCODE dbSUPER 11.5 -37.5 -37525 1.5 PKNOX1 ZNF76 SIN3A ZNF2 ETS1 GLIS2 ZNF143 EGR2 SP3 HCFC1 TMEM63C ZDHHC22 NGB FAM204DP GC14M077202 ENSG00000201384
GH14H077142 1 ENCODE dbSUPER 11.3 +2.1 2096 1.6 CTCF MXI1 ZIC2 GLIS2 GATA3 POLR2A PATZ1 ZNF600 PRDM10 ZBTB20 ZDHHC22 TMEM63C ENSG00000269883
GH14H077299 1 ENCODE dbSUPER 11 -156.4 -156362 2.4 CTCF FOXA2 NFIB ARID4B RAD21 SMC3 ZNF143 NR2F6 ZNF654 NRF1 GSTZ1 POMT2 NGB MIR1260A ZDHHC22 ENSG00000201384 VIPAS39 AHSA1 CIPC PIR44060
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZDHHC22 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZDHHC22 Gene

Genomic Locations for ZDHHC22 Gene
12,999 bases
Minus strand

Genomic View for ZDHHC22 Gene

Genes around ZDHHC22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC22 Gene

Proteins for ZDHHC22 Gene

  • Protein details for ZDHHC22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Palmitoyltransferase ZDHHC22
    Protein Accession:
    Secondary Accessions:
    • A6NH02
    • B7Z2L5
    • Q149P4

    Protein attributes for ZDHHC22 Gene

    263 amino acids
    Molecular mass:
    29100 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZDHHC22 Gene

Post-translational modifications for ZDHHC22 Gene

No Post-translational modifications

Other Protein References for ZDHHC22 Gene

No data available for DME Specific Peptides for ZDHHC22 Gene

Domains & Families for ZDHHC22 Gene

Gene Families for ZDHHC22 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ZDHHC22 Gene

Suggested Antigen Peptide Sequences for ZDHHC22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
genes like me logo Genes that share domains with ZDHHC22: view

Function for ZDHHC22 Gene

Molecular function for ZDHHC22 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
UniProtKB/Swiss-Prot Function:
Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane.

Enzyme Numbers (IUBMB) for ZDHHC22 Gene

Phenotypes From GWAS Catalog for ZDHHC22 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC22: view
genes like me logo Genes that share phenotypes with ZDHHC22: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC22 Gene

Localization for ZDHHC22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC22 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC22 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
extracellular 3
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZDHHC22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 16647879
GO:0005794 Golgi apparatus IDA 16647879
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC22: view

Pathways & Interactions for ZDHHC22 Gene

SuperPathways for ZDHHC22 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC22 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZDHHC22 Gene

Drugs & Compounds for ZDHHC22 Gene

(1) Drugs for ZDHHC22 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for ZDHHC22 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZDHHC22: view

Transcripts for ZDHHC22 Gene

Unigene Clusters for ZDHHC22 Gene

Zinc finger, DHHC-type containing 22:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC22 Gene

No ASD Table

Relevant External Links for ZDHHC22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZDHHC22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZDHHC22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZDHHC22 Gene

This gene is overexpressed in Brain - Cortex (x8.1), Brain - Frontal Cortex (BA9) (x7.8), Brain - Anterior cingulate cortex (BA24) (x6.3), Brain - Hypothalamus (x5.6), and Brain - Hippocampus (x5.1).

NURSA nuclear receptor signaling pathways regulating expression of ZDHHC22 Gene:


SOURCE GeneReport for Unigene cluster for ZDHHC22 Gene:


Evidence on tissue expression from TISSUES for ZDHHC22 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with ZDHHC22: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC22 Gene

Orthologs for ZDHHC22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZDHHC22 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZDHHC22 33 34
  • 99.87 (n)
(Canis familiaris)
Mammalia ZDHHC22 33 34
  • 93.66 (n)
(Bos Taurus)
Mammalia ZDHHC22 33 34
  • 92.27 (n)
(Rattus norvegicus)
Mammalia Zdhhc22 33
  • 91.13 (n)
(Mus musculus)
Mammalia Zdhhc22 33 16 34
  • 89.86 (n)
(Monodelphis domestica)
Mammalia ZDHHC22 34
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia ZDHHC22 34
  • 47 (a)
(Gallus gallus)
Aves ZDHHC22 33 34
  • 78.07 (n)
(Anolis carolinensis)
Reptilia ZDHHC22 34
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc22 33
  • 54.86 (n)
(Danio rerio)
Actinopterygii LOC100000886 33
  • 57.18 (n)
ZDHHC22 34
  • 44 (a)
Species where no ortholog for ZDHHC22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZDHHC22 Gene

Gene Tree for ZDHHC22 (if available)
Gene Tree for ZDHHC22 (if available)

Paralogs for ZDHHC22 Gene

No data available for Paralogs for ZDHHC22 Gene

Variants for ZDHHC22 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC22 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000044882 -- 77,146,192(+) CAAGC(A/G)AGTAC utr-variant-5-prime
rs1000305382 -- 77,140,158(+) AGGAG(C/G)AGAAA intron-variant
rs1000338886 -- 77,133,575(+) GGACC(C/T)TACCA utr-variant-3-prime
rs1000467899 -- 77,139,964(+) CACCT(G/T)GGGGT intron-variant
rs1000659561 -- 77,139,876(+) TGTCC(C/G)GCGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC22 Gene

Variant ID Type Subtype PubMed ID
nsv952870 CNV deletion 24416366
nsv832834 CNV gain+loss 17160897
esv3634998 CNV loss 21293372

Variation tolerance for ZDHHC22 Gene

Residual Variation Intolerance Score: 70.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 8.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZDHHC22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC22 Gene

Disorders for ZDHHC22 Gene

Relevant External Links for ZDHHC22

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZDHHC22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC22 Gene

Publications for ZDHHC22 Gene

  1. Distinct acyl protein transferases and thioesterases control surface expression of calcium-activated potassium channels. (PMID: 22399288) Tian L … Shipston MJ (The Journal of biological chemistry 2012) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. (PMID: 24262325) Dichgans M … International Stroke Genetics Consortium (Stroke 2014) 3 60
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60

Products for ZDHHC22 Gene

Sources for ZDHHC22 Gene

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