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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZDHHC22 Gene

protein-coding GIFtS: 38
GCID: GC14M077597

zinc finger, DHHC-type containing 22

(Previous name: chromosome 14 open reading frame 59 )
(Previous symbol: C14orf59)

Search for ZDHHC22
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger, DHHC-Type Containing 22¹ ²		Chromosome 14 Open Reading Frame 59¹
C14orf59¹ ² ³		Putative Palmitoyltransferase ZDHHC22²
Zinc Finger DHHC Domain-Containing Protein 22² ³		Zinc Finger, DHHC Domain Containing 22²
DHHC-22² ³		EC 2.3.1.-³

External Ids:	HGNC: 20106¹	Entrez Gene: 283576²	Ensembl: ENSG00000177108⁷	UniProtKB: Q8N966³

Export aliases for ZDHHC22 gene to outside databases

Previous GC identifers: GC14M075588 GC14M076667 GC14M057765

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZDHHC22 gene promoter:
C/EBPbeta MyoD Olf-1 HNF-4alpha2 Nkx2-5 C/EBPalpha HNF-4alpha1 AREB6 CHOP-10 HFH-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZDHHC22 promoter sequence

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZDHHC22

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3 Ensembl cytogenetic band: 14q24.3 HGNC cytogenetic band: 14q24.3

ZDHHC22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZDHHC22 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M077597: view genomic region (about GC identifiers)

Start:	77,597,613 bp from pter	End:	77,609,077 bp from pter
Size:	11,465 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZDH22_HUMAN, Q8N966 (See protein sequence)

Recommended Name: Putative palmitoyltransferase ZDHHC22

Size: 263 amino acids; 29100 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: A6NH02 B7Z2L5 Q149P4

Explore the universe of human proteins at neXtProt for ZDHHC22: NX_Q8N966

ZDHHC22 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_777636.2

ENSEMBL proteins:

ENSP00000318222 ENSP00000451337 ENSP00000450478

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

ZDHHC22 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZDHHC22 for domains About GeneDecksing

2 InterPro domains/families:

IPR001594 Znf_DHHC_palmitoyltrfase

IPR000731 SSD

Graphical View of Domain Structure for InterPro Entry Q8N966

ProtoNet protein and cluster: Q8N966

1 Blocks protein family: IPB001594 Zn-finger

UniProtKB/Swiss-Prot: ZDH22_HUMAN, Q8N966

Domain: The DHHC domain is required for palmitoyltransferase activity (By similarity)

Similarity: Belongs to the DHHC palmitoyltransferase family

Similarity: Contains 1 DHHC-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZDH22_HUMAN, Q8N966

Catalytic activity: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA

Enzyme Number (IUBMB): EC 2.3.1.-¹

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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008270	zinc ion binding	IEA	--
GO:0016746	transferase activity, transferring acyl groups	IEA	--

ZDHHC22 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZDHHC22

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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Search CenterWatch for drugs/clinical trials and news about ZDHHC22 / ZDH22

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for ZDHHC22 gene:

NM_174976.2

Unigene Cluster for ZDHHC22:

Zinc finger, DHHC-type containing 22

Hs.525485 [show with all ESTs]

Unigene Representative Sequence: NM_174976

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000319374(uc010asp.3) ENST00000555389 ENST00000555327

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Additional cDNA sequence:

AK294840.1 BC035881.1 BC117676.2

5 DOTS entries:

DT.206428 DT.75169762 DT.120748816 DT.431939 DT.95220016

24/41 AceView cDNA sequences (see all 41):

AA011100 BU738548 AA778997 BE222693 BG222817 AI086469 AI363193 BF346302

BC035881 BE258387 BG057078 BE778331 AA412615 CB155793 AI272285 AK095612

BU193017 NM_174976 AI085337 AW005908 AI417394 AI094961 BM713119 BE267333

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZDHHC22 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCCTGTATT

About this image

ZDHHC22 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ZDHHC22 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZDHHC22

SOURCE GeneReport for Unigene cluster: Hs.525485

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ZDHHC22 gene from 5/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Zdhhc22^{1 , 5}	zinc finger, DHHC-type containing 22^{1, 5}	89.86(n)¹ 92.4(a)¹		12 (41.17 cM)⁵ 238331¹ NM_001080943.2¹ NP_001074412.1¹ 86983381⁵
chicken (Gallus gallus)	Aves	ZDHHC22¹	zinc finger, DHHC-type containing 22	78.07(n) 79.47(a)		428895 XM_426450.2 XP_426450.2
lizard (Anolis carolinensis)	Reptilia	ZDHHC22⁶	--	76(a)	1 ↔ 1	1(21043456-21056841)
zebrafish (Danio rerio)	Actinopterygii	LOC100000886¹	putative palmitoyltransferase ZDHHC22-like	57.88(n) 52.72(a)		100000886 XM_001340956.1 XP_001340992.1
worm (Caenorhabditis elegans)	Secernentea	dhhc-1⁶ K02G10.1⁶	Protein K02G10.1	17(a) 16(a)	possible ortholog 1 ↔ 1	X(15097997-15100335) X(4707159-4709783)

ENSEMBL Gene Tree for ZDHHC22 (if available)
TreeFam Gene Tree for ZDHHC22 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZDHHC22 gene

ZDHHC24²

ZDHHC22 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78936949^1,2	F,	--	77597192(+)	`ATATTC/ACATCT`	1	--	ds500¹		1		WA	118
rs11623987^1,2	H	--	77597241(+)	`TCTGGG/TTACCA`	1	--	ds500¹		0	--	--	--	--
rs11624022^1,2	H	--	77597268(+)	`TCTGGG/TTACCA`	1	--	ds500¹		0	--	--	--	--
rs115599664^1,2	C,F,	--	77597270(+)	`TGGTTA/GCCAAC`	1	--	ds500¹		1		WA	118
rs2661832^1,2	C,F,A,H,	--	77597381(-)	`ATCATG/TCCTGG`	1	--	ds500¹		25		NS EA NA WA CSA	2355
rs77529935^1,2	C,F,	--	77597552(+)	`AGCTAG/ATATGG`	1	--	ds500¹		1		WA	118
rs55734127^1,2	C,	--	77597958(+)	`CAGCGA/GCTCCT`	1	--	ut3¹		2		WA	120
rs117430319^1,2	F,	--	77597995(+)	`CTTCAG/ACCATC`	1	--	ut3¹		1		EA	120
rs116302291^1,2	C,F,	--	77598048(+)	`ACCAAG/TATGGC`	1	--	ut3¹		1		WA	118
rs186276236^1,2		--	77598179(+)	`GGAACA/GTAGTT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZDHHC22 (77597613 - 77609077 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZDHHC22
1 CNV: 4840

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZDHHC22 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZDHHC22)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)² Heilig R.... Weissenbach J. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
The sequence of the human genome. (PubMed id 11181995)¹ Venter J.C.... Zhu X. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 283576	HGNC: 20106	AceView: ZDHHC22	Ensembl:ENSG00000177108	euGenes: HUgn283576
ECgene: ZDHHC22	H-InvDB: ZDHHC22

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZDHHC22	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZDHHC22 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZDHHC22 gene:
Search GeneIP for patents involving ZDHHC22

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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In Situ Hybridization Assays from
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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZDHHC22 gene at Home site.

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ZDHHC22 Gene

zinc finger, DHHC-type containing 22

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ZDHHC22 Gene

zinc finger, DHHC-type containing 22

Aliasesfor ZDHHC22 gene

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