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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZDHHC22 Gene

protein-coding   GIFtS: 36
GCID: GC14M077597

Zinc Finger, DHHC-Type Containing 22

(Previous name: chromosome 14 open reading frame 59)
(Previous symbol: C14orf59)
  Search for ZDHHC22
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger, DHHC-Type Containing 221 2     Chromosome 14 Open Reading Frame 591
C14orf591 2 3     Putative Palmitoyltransferase ZDHHC222
Zinc Finger DHHC Domain-Containing Protein 222 3     Zinc Finger, DHHC Domain Containing 222
DHHC-222 3     EC 2.3.1.-3

External Ids:    HGNC: 201061   Entrez Gene: 2835762   Ensembl: ENSG000001771087   UniProtKB: Q8N9663   

Export aliases for ZDHHC22 gene to outside databases

Previous GC identifers: GC14M075588 GC14M076667 GC14M057765


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZDHHC22 Gene: 
ZDHHC22 (zinc finger, DHHC-type containing 22) is a protein-coding gene. GO annotations related to this gene include transferase activity, transferring acyl groups and zinc ion binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZDHHC22 gene promoter:
         C/EBPbeta   MyoD   Olf-1   HNF-4alpha2   Nkx2-5   C/EBPalpha   HNF-4alpha1   AREB6   CHOP-10   HFH-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZDHHC22 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZDHHC22

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZDHHC22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.3

ZDHHC22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZDHHC22 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M077597:  view genomic region     (about GC identifiers)

Start:
77,597,613 bp from pter      End:
77,609,077 bp from pter
Size:
11,465 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZDH22_HUMAN, Q8N966 (See protein sequence)
Recommended Name: Putative palmitoyltransferase ZDHHC22  
Size: 263 amino acids; 29100 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: A6NH02 B7Z2L5 Q149P4

Explore the universe of human proteins at neXtProt for ZDHHC22: NX_Q8N966

Explore proteomics data for ZDHHC22 at MOPED 

ZDHHC22 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

ZDHHC22 Protein Expression

REFSEQ proteins: NP_777636.2  
ENSEMBL proteins: 
 ENSP00000318222   ENSP00000451337   ENSP00000450478  

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral to membrane IEA--

ZDHHC22 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
ZDHHC: Zinc fingers, DHHC-type

2 InterPro protein domains:
 IPR001594 Znf_DHHC_palmitoyltrfase
 IPR000731 SSD

Graphical View of Domain Structure for InterPro Entry Q8N966

ProtoNet protein and cluster: Q8N966

1 Blocks protein domain: IPB001594 Zn-finger

UniProtKB/Swiss-Prot: ZDH22_HUMAN, Q8N966
Domain: The DHHC domain is required for palmitoyltransferase activity (By similarity)
Similarity: Belongs to the DHHC palmitoyltransferase family
Similarity: Contains 1 DHHC-type zinc finger


ZDHHC22 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: ZDH22_HUMAN, Q8N966
Catalytic activity: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA

     Enzyme Number (IUBMB): EC 2.3.1.-1

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008270zinc ion binding IEA--
GO:0016746transferase activity, transferring acyl groups IEA--
     
ZDHHC22 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZDHHC22

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0018345protein palmitoylation IEA--
GO:0072659protein localization to plasma membrane IEA--

ZDHHC22 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZDHHC22 (ZDH22)

Search CenterWatch for drugs/clinical trials and news about ZDHHC22 / ZDH22

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZDHHC22 gene: 
NM_174976.2  

Unigene Cluster for ZDHHC22:

Zinc finger, DHHC-type containing 22
Hs.525485  [show with all ESTs]
Unigene Representative Sequence: NM_174976
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000319374(uc010asp.3) ENST00000555389 ENST00000555327
miRNA
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SwitchGear 3'UTR luciferase reporter plasmidZDHHC22 3' UTR sequence
Inhib. RNA
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Additional mRNA sequence: 

AK294840.1 BC035881.1 BC117676.2 

5 DOTS entries:

DT.206428  DT.75169762  DT.120748816  DT.431939  DT.95220016 

24/41 AceView cDNA sequences (see all 41):

BG222817 BU738548 AI086469 AA011100 AA778997 AI363193 BE222693 BM713119 
AW005908 CB155793 AI085337 AI417394 BQ440170 AI272285 AA412615 BC035881 
BU193017 CF264712 NM_174976 AK095612 BG057078 AI094961 BE258387 BE267333 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZDHHC22 expression in normal human tissues (normalized intensities)      ZDHHC22 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCCCTGTATT
ZDHHC22 Expression
About this image


ZDHHC22 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/2 selected tissues (see all 2) fully expand
 
 Inner Cell Mass (Early Embryonic Tissues)
         Line H9 (WA09)
 
 Brain (Nervous System)

See ZDHHC22 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZDHHC22

SOURCE GeneReport for Unigene cluster: Hs.525485
    SABiosciences Custom PCR Arrays for ZDHHC22
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ZDHHC22 gene from 5/12 species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Zdhhc221 , 5 zinc finger, DHHC-type containing 221, 5 89.86(n)1
92.4(a)1
  12 (41.17 cM)5
2383311  NM_001080943.21  NP_001074412.11 
 869833815 
chicken
(Gallus gallus)
Aves ZDHHC221 zinc finger, DHHC-type containing 22 78.07(n)
79.47(a)
  428895  XM_426450.2  XP_426450.2 
lizard
(Anolis carolinensis)
Reptilia ZDHHC226
Uncharacterized protein
74(a)
1 ↔ 1
1(21043442-21056841)
zebrafish
(Danio rerio)
Actinopterygii LOC1000008861 putative palmitoyltransferase ZDHHC22-like 57.88(n)
52.72(a)
  100000886  XM_001340956.1  XP_001340992.1 
worm
(Caenorhabditis elegans)
Secernentea dhhc-16
dhhc-106
Protein K02G10.1
17(a)
13(a)
many → 1
many → 1
X(15098067-15100405)
X(4707188-4709812)


ENSEMBL Gene Tree for ZDHHC22 (if available)
TreeFam Gene Tree for ZDHHC22 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/265 SNPs in ZDHHC22 are shown (see all 265)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 14 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs789369491,2
C,F--77597192(+) ATATTC/ACATCT 1 -- ds50011Minor allele frequency- A:0.04WA 118
rs116239871,2
H--77597241(+) TCTGGG/TTACCA 1 -- ds50010--------
rs116240221,2
H--77597268(+) TCTGGG/TTACCA 1 -- ds50010--------
rs1155996641,2
C,F--77597270(+) TGGTTA/GCCAAC 1 -- ds50011Minor allele frequency- G:0.04WA 118
rs26618321,2
C,F,A,H--77597381(-) ATCATG/TCCTGG 1 -- ds500125Minor allele frequency- T:0.13NS EA NA WA CSA 2355
rs775299351,2
C,F--77597552(+) AGCTAG/ATATGG 1 -- ds50011Minor allele frequency- A:0.06WA 118
rs557341271,2
C--77597958(+) CAGCGA/GCTCCT 1 -- ut312Minor allele frequency- G:0.07WA 120
rs1174303191,2
C,F--77597995(+) CTTCAG/ACCATC 1 -- ut311Minor allele frequency- A:0.02EA 120
rs1163022911,2
C,F--77598048(+) ACCAAG/TATGGC 1 -- ut311Minor allele frequency- T:0.05WA 118
rs1862762361,2
--77598179(+) GGAACA/GTAGTT 1 -- ut310--------

HapMap Linkage Disequilibrium report for ZDHHC22 (77597613 - 77609077 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for ZDHHC22:    About this table     
Variant IDTypeSubtypePubMed ID
nsv832834CNV Gain+Loss17160897

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for ZDHHC22 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZDHHC22)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  4. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  6. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 283576 HGNC: 20106 AceView: ZDHHC22 Ensembl:ENSG00000177108 euGenes: HUgn283576
ECgene: ZDHHC22 H-InvDB: ZDHHC22

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for ZDHHC22 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for ZDHHC22 gene:
Search GeneIP for patents involving ZDHHC22

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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