ZDHHC21 Gene
protein-coding GIFtS: 48
GCID: GC09M014605
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zinc finger, DHHC-type containing 21
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Aliases for ZDHHC21 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Zinc Finger, DHHC-Type Containing 211 2 | | DHHC212 | | DNZ11 2 | | Palmitoyltransferase ZDHHC212 | | HSPC0971 2 | | Probable Palmitoyltransferase ZDHHC212 | | Zinc Finger DHHC Domain-Containing Protein 212 3 | | Zinc Finger, DHHC Domain Containing 212 | | DHHC-212 3 | | EC 2.3.1.-3 | | 9130404H11Rik2 | | EC 2.3.18 |
Export aliases for ZDHHC21 gene to outside databasesPrevious GC identifers: GC00U907487 GC09M014607 |
Summaries for ZDHHC21 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: ZDH21_HUMAN, Q8IVQ6Function: Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targetingto the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and thegeneration of cAMP, but does not affect that mediated by their nuclear receptor (By similarity)
|
Genomic Views for ZDHHC21 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ZDHHC21 gene promoter: Nkx3-1 LHX3b/Lhx3b Nkx3-1 v4 AML1a Nkx3-1 v1 LUN-1 RORalpha1 Nkx3-1 v2 Nkx3-1 v3 LHX3a/Lhx3a Other transcription factors
Search SABiosciences Chromatin IP Primers for ZDHHC21
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZDHHC21 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p22.3 Ensembl cytogenetic band: 9p22.3 HGNC cytogenetic band: 9p22.3ZDHHC21 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M014605: view genomic region
(about GC identifiers)
Start:
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14,611,069 bp from pter |
End:
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14,693,480 bp from pter |
Size:
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82,412 bases |
Orientation:
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minus strand |
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Proteins for ZDHHC21 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: ZDH21_HUMAN, Q8IVQ6 (See
protein sequence)Recommended Name: Palmitoyltransferase ZDHHC21 Size: 265 amino acids; 31385 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential). Golgi apparatus (By similarity)
Secondary accessions: A8KA95 D3DRI7 Q5VWG1Explore the universe of human proteins at neXtProt for ZDHHC21: NX_Q8IVQ6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IVQ6 3 DME Specific Peptides for ZDHHC21 (Q8IVQ6)
ZDHHC21 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_848661.1 ENSEMBL proteins: ENSP00000370303 Reactome Protein details: Q8IVQ6 Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ZDHHC21 for ontologies About GeneDecksing
ZDHHC21 Antibody Products: Assay Products for ZDHHC21: |
Protein
Domains / Families for ZDHHC21 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZDHHC21 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8IVQ6ProtoNet protein and cluster: Q8IVQ6 1 Blocks protein family: IPB001594 Zn-finger
UniProtKB/Swiss-Prot: ZDH21_HUMAN, Q8IVQ6Domain: The DHHC domain is required for palmitoyltransferase activity (By similarity)Similarity: Belongs to the DHHC palmitoyltransferase familySimilarity: Contains 1 DHHC-type zinc finger |
Function for ZDHHC21 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: ZDH21_HUMAN, Q8IVQ6Function: Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targetingto the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and thegeneration of cAMP, but does not affect that mediated by their nuclear receptor (By similarity)Catalytic activity: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoAEnzyme Numbers (IUBMB): EC 2.3.12 EC 2.3.1.-1
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC21 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC21 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZDHHC21 (NM_178566) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZDHHC21 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZDHHC21  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC21 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- | | GO:0016409 | palmitoyltransferase activity |
IEA | -- |
ZDHHC21 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZDHHC21: Animal Models: 4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Zdhhc21):
ZDHHC21 for phenotypes About GeneDecksing
|
Pathways & Interactions for ZDHHC21 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Metabolism of nitric oxide | | | 2 | Metabolism | |
Pathway sources See GeneCards unified pathways Show all pathways
4
Reactome Pathways for ZDHHC21
ZDHHC21 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZDHHC21
1 Interacting protein for ZDHHC21 (Q8IVQ63) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001942 | hair follicle development |
IEA | -- | | GO:0018230 | peptidyl-L-cysteine S-palmitoylation |
IMP | -- | | GO:0018345 | protein palmitoylation |
-- | -- | | GO:0044281 | small molecule metabolic process |
TAS | -- | | GO:0046209 | nitric oxide metabolic process |
TAS | -- |
ZDHHC21 for ontologies About GeneDecksing
|
Drugs & Compounds for ZDHHC21 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for ZDHHC21 Search CenterWatch for drugs/clinical trials and news about ZDHHC21 / ZDH21 
|
Transcripts for ZDHHC21 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for ZDHHC21 gene: NM_178566.4 Unigene Clusters for ZDHHC21: Zinc finger, DHHC-type containing 21 Hs.649522 [show with all ESTs], Hs.740511 [show with all ESTs]Unigene Representative Sequences: AK124263, NM_1785662 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000380916(uc003zlg.2 uc003zlh.2) ENST00000497966
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC21 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC21 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZDHHC21 (NM_178566) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZDHHC21 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZDHHC21  |
Additional cDNA sequence: AF161360.1 AK026322.1 AK096860.1 AK127313.1 AK292960.1 BC042439.1 BC042558.1 8 DOTS entries: DT.109484 DT.97802447 DT.110189 DT.75188405 DT.443263 DT.100814140 DT.121145262 DT.95251223 24/110 AceView cDNA sequences (see all 110): AL539073 BQ009516 AI658548 AW134761 AA454645 AA402623 BM721007 AA489238 AW468985 AA278314 BX091719 BF940847 AA456258 CR606494 BG564357 AK124263 AI807206 AA743491 AI806563 AA564788 CD000002 AA789312 BM739547 AL699289 GeneLoc Exon Structure
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Expression for ZDHHC21 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZDHHC21 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: --
About this image See ZDHHC21 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ZDHHC21
SOURCE GeneReport for Unigene clusters: Hs.649522 Hs.740511 SABiosciences Custom PCR Arrays for ZDHHC21
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZDHHC21 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZDHHC21 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZDHHC21 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZDHHC21 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC21 |
Orthologs for ZDHHC21 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ZDHHC21 gene from 8/29 species (see all 29) About this table
ENSEMBL Gene Tree for ZDHHC21 (if available) TreeFam Gene Tree for ZDHHC21 (if available)  |
Paralogs for ZDHHC21 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for ZDHHC21 gene
- ZDHHC32 ZDHHC72 ZDHHC202 ZDHHC232 ZDHHC152 ZDHHC22
ZDHHC21 for paralogs About GeneDecksing
|
Genomic Variants for ZDHHC21 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 9 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for ZDHHC21 (14611069 - 14693480 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 7 variations for ZDHHC21 6 CNVs: 95854 65340 4615 100590 82891 30329 1 Indel: 47685  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZDHHC21 |
|
Disorders
/ Diseases for ZDHHC21 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZDHHC21 for disorders About GeneDecksing
OMIM gene information: 614605
OMIM disorders: --
1 disease for ZDHHC21: About MalaCardsmalaria Export disorders for ZDHHC21 gene to outside databases
|
Publications for ZDHHC21 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZDHHC21 gene, integrated from 9 sources (see all 11): (articles sorted by number of sources associating them with ZDHHC21) | |  | Utopia: connect your pdf to the dynamic world of online information |
- DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors. (PubMed id 22031296)1, 2 Pedram A.... Levin E.R. (2012)
- Palmitoylation regulates epidermal homeostasis and ha ir follicle differentiation. (PubMed id 19956733)1, 3 Mill P....Jackson I.J. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- Endothelial cell palmitoylproteomic identifies novel l ipid-modified targets and potential substrates for protein acyl transferases. (PubMed id 22496122)1 Marin E.P....Sessa W.C. (2012)
- Novel associations for hypothyroidism include known au toimmune risk loci. (PubMed id 22493691)1 Eriksson N....Do C.B. (2012)
- Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
- Genomewide association study of a rapid progression c ohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Associati on Study 03). (PubMed id 19754311)1 Le Clerc S....Sladek R. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
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External Searches for ZDHHC21 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ZDHHC21 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZDHHC21 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZDHHC21 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for ZDHHC21 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZDHHC21 gene: Search GeneIP for patents involving ZDHHC21
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for ZDHHC21 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
| | | | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZDHHC21 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZDHHC21 | | OriGene Protein Over-expression Lysate for ZDHHC21 | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for ZDHHC21 | | Browse 3'-UTR reporter clones for miRNA target validation | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC21 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC21 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | Search Tocris compounds for ZDHHC21 |
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 | | ZDHHC21 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC21 |
|  |  |  | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZDHHC21 |
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