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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZDHHC21 Gene

protein-coding   GIFtS: 48
GCID: GC09M014605

zinc finger, DHHC-type containing 21

 Explore 1 disease affiliated with
ZDHHC21 via our new
 Human Malady Compendium 
Biological research products
for ZDHHC21
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger, DHHC-Type Containing 211 2     DHHC212
DNZ11 2     Palmitoyltransferase ZDHHC212
HSPC0971 2     Probable Palmitoyltransferase ZDHHC212
Zinc Finger DHHC Domain-Containing Protein 212 3     Zinc Finger, DHHC Domain Containing 212
DHHC-212 3     EC 2.3.1.-3
9130404H11Rik2     EC 2.3.18

External Ids:    HGNC: 207501   Entrez Gene: 3404812   Ensembl: ENSG000001758937   OMIM: 6146055   UniProtKB: Q8IVQ63   

Export aliases for ZDHHC21 gene to outside databases

Previous GC identifers: GC00U907487 GC09M014607


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZDH21_HUMAN, Q8IVQ6
Function: Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting
to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the
generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZDHHC21 gene promoter:
         Nkx3-1   LHX3b/Lhx3b   Nkx3-1 v4   AML1a   Nkx3-1 v1   LUN-1   RORalpha1   Nkx3-1 v2   Nkx3-1 v3   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZDHHC21 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZDHHC21

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZDHHC21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22.3   Ensembl cytogenetic band:  9p22.3   HGNC cytogenetic band: 9p22.3

ZDHHC21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZDHHC21 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M014605:  view genomic region     (about GC identifiers)

Start:
14,611,069 bp from pter      End:
14,693,480 bp from pter
Size:
82,412 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZDH21_HUMAN, Q8IVQ6 (See protein sequence)
Recommended Name: Palmitoyltransferase ZDHHC21  
Size: 265 amino acids; 31385 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential). Golgi apparatus (By similarity)
Secondary accessions: A8KA95 D3DRI7 Q5VWG1

Explore the universe of human proteins at neXtProt for ZDHHC21: NX_Q8IVQ6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8IVQ6

  • 3 DME Specific Peptides for ZDHHC21 (Q8IVQ6)
     MDHHCPW  CVRRMDHHC  TDPGRLPENPKIPH 

    ZDHHC21 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_848661.1  
    ENSEMBL proteins: 
     ENSP00000370303  
    Reactome Protein details: Q8IVQ6
    Human Recombinant Protein Products: 
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    Uscn Proteins for ZDHHC21

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005794Golgi apparatus IDA--
    GO:0016021integral to membrane IEA--


    ZDHHC21 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZDHHC21 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001594 Znf_DHHC_palmitoyltrfase

    Graphical View of Domain Structure for InterPro Entry Q8IVQ6

    ProtoNet protein and cluster: Q8IVQ6

    1 Blocks protein family: IPB001594 Zn-finger

    UniProtKB/Swiss-Prot: ZDH21_HUMAN, Q8IVQ6
    Domain: The DHHC domain is required for palmitoyltransferase activity (By similarity)
    Similarity: Belongs to the DHHC palmitoyltransferase family
    Similarity: Contains 1 DHHC-type zinc finger


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ZDH21_HUMAN, Q8IVQ6
    Function: Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting
    to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the
    generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity)
    Catalytic activity: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA

    Enzyme Numbers (IUBMB): EC 2.3.12 EC 2.3.1.-1

    miRNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
    GO:0016409palmitoyltransferase activity IEA--


    ZDHHC21 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ZDHHC21:
     Decreased nuclei size in G2M 

    Animal Models:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Zdhhc21):
     craniofacial  endocrine/exocrine gland  integument  pigmentation 

    ZDHHC21 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Metabolism of nitric oxide
    Metabolism of nitric oxide1.00
    eNOS activation0.41
    eNOS activation and regulation1.00
    2Metabolism
    Metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for ZDHHC21
        eNOS activation and regulation
    Metabolism of nitric oxide
    eNOS activation
    Metabolism



    ZDHHC21 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZDHHC21

    1 Interacting protein for ZDHHC21 (Q8IVQ63) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREB3O438893I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001942hair follicle development IEA--
    GO:0018230peptidyl-L-cysteine S-palmitoylation IMP--
    GO:0018345protein palmitoylation ----
    GO:0044281small molecule metabolic process TAS--
    GO:0046209nitric oxide metabolic process TAS--


    ZDHHC21 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZDHHC21
    Search CenterWatch for drugs/clinical trials and news about ZDHHC21 / ZDH21 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZDHHC21 gene: 
    NM_178566.4  

    Unigene Clusters for ZDHHC21:

    Zinc finger, DHHC-type containing 21
    Hs.649522  [show with all ESTs], Hs.740511  [show with all ESTs]
    Unigene Representative Sequences: AK124263, NM_178566
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380916(uc003zlg.2 uc003zlh.2) ENST00000497966

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    hsa-miR-605 hsa-miR-3653 hsa-miR-4275 hsa-miR-92b hsa-miR-32 hsa-miR-548y hsa-miR-587 hsa-miR-199a-5p
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    Additional cDNA sequence: 

    AF161360.1 AK026322.1 AK096860.1 AK127313.1 AK292960.1 BC042439.1 BC042558.1 

    8 DOTS entries:

    DT.109484  DT.97802447  DT.110189  DT.75188405  DT.443263  DT.100814140  DT.121145262  DT.95251223 

    24/110 AceView cDNA sequences (see all 110):

    AL539073 BQ009516 AI658548 AW134761 AA454645 AA402623 BM721007 AA489238 
    AW468985 AA278314 BX091719 BF940847 AA456258 CR606494 BG564357 AK124263 
    AI807206 AA743491 AI806563 AA564788 CD000002 AA789312 BM739547 AL699289 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZDHHC21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ZDHHC21 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZDHHC21

    SOURCE GeneReport for Unigene clusters: Hs.649522 Hs.740511
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ZDHHC21 gene from 8/29 species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ZDHHC211 zinc finger, DHHC-type containing 21 80.75(n)
    82.64(a)
      427356  NM_001031438.1  NP_001026609.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZDHHC216
    --
    79(a)
    1 ↔ 1
    2(34520543-34550822)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.305702 Xenopus laevis transcribed sequence 79.11(n)    48046489 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1584201 zgc:158420 65.15(n)
    64.64(a)
      100144560  NM_001123055.1  NP_001116527.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dnz16
    DNZDHHC/NEW1 zinc finger protein 11
    20(a)
    1 ↔ 1
    2L(10854435-10856644)
    worm
    (Caenorhabditis elegans)
    Secernentea C17D12.16
    Protein C17D12.1, isoform b
    21(a)
    1 ↔ 1
    I(11611663-11616130)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G042706
    AT3G093206
    putative S-acyltransferase
    20(a)
    17(a)
    possible ortholog
    possible ortholog
    5(1182718-1184765)
    3(2861743-2864245)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 3)
    DHHC zinc finger domain containing protein, expres...
    DHHC zinc finger domain containing protein, expres...
    (see all 3)
    18(a)
    18(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    2(35149792-35152853)
    1(36256392-36260701)


    ENSEMBL Gene Tree for ZDHHC21 (if available)
    TreeFam Gene Tree for ZDHHC21 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZDHHC21 gene
    ZDHHC32  ZDHHC72  ZDHHC202  ZDHHC232  ZDHHC152  ZDHHC22  

    ZDHHC21 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1813 NCBI SNPs in ZDHHC21 are shown (see all 1813    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1816670011,2
    --14610571(+) ACTCAC/TTGTCT 1 -- ds50010--------
    rs13437061,2
    C,F,O,A,H,--14610591(+) GCTGAT/CTGATT 1 -- ds500122Minor allele frequency- C:0.33NA NS EA WA 2484
    rs1863353551,2
    --14610625(+) TTTTTA/GGCCAA 1 -- ds50010--------
    rs13437051,2
    C,F,O,A,H,--14610866(+) TTTCAA/GCCCTA 1 -- ds500130Minor allele frequency- G:0.30EA NA NS WA CSA 2974
    rs1164916041,2
    C,F,--14610920(+) ATTATG/AGCAGA 1 -- ds50011Minor allele frequency- A:0.05WA 118
    rs1912335711,2
    --14610938(+) CCTAAC/GGCTAG 1 -- ds50010--------
    rs1436598761,2
    --14610972(+) TGTATA/CAAATT 1 -- ds50010--------
    rs1383592101,2
    --14610981(+) TTTTTA/CAAAGT 1 -- ds50010--------
    rs169320561,2
    C,F,--14611025(+) TTTGGG/TTTAAT 1 -- ds50015Minor allele frequency- T:0.05NA WA 262
    rs126827371,2
    H--14611066(+) AACAGT/ACCTAC 1 -- ds50014Minor allele frequency- A:0.00NS EA 412

    HapMap Linkage Disequilibrium report for ZDHHC21 (14611069 - 14693480 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for ZDHHC21
         6 CNVs: 95854 65340 4615 100590 82891 30329
         1 Indel: 47685

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZDHHC21 for disorders           About GeneDecksing

    OMIM gene information: 614605    OMIM disorders: --

    1 disease for ZDHHC21:    About MalaCards
    malaria


    Export disorders for ZDHHC21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZDHHC21 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with ZDHHC21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors. (PubMed id 22031296)1, 2 Pedram A.... Levin E.R. (2012)
    2. Palmitoylation regulates epidermal homeostasis and ha ir follicle differentiation. (PubMed id 19956733)1, 3 Mill P....Jackson I.J. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    6. Endothelial cell palmitoylproteomic identifies novel l ipid-modified targets and potential substrates for protein acyl transferases. (PubMed id 22496122)1 Marin E.P....Sessa W.C. (2012)
    7. Novel associations for hypothyroidism include known au toimmune risk loci. (PubMed id 22493691)1 Eriksson N....Do C.B. (2012)
    8. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
    9. Genomewide association study of a rapid progression c ohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Associati on Study 03). (PubMed id 19754311)1 Le Clerc S....Sladek R. (2009)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 340481 HGNC: 20750 AceView: ZDHHC21 Ensembl:ENSG00000175893 euGenes: HUgn340481
    ECgene: ZDHHC21 H-InvDB: ZDHHC21

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZDHHC21 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZDHHC21 gene:
    Search GeneIP for patents involving ZDHHC21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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