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Aliases for ZDHHC21 Gene

Aliases for ZDHHC21 Gene

  • Zinc Finger DHHC-Type Containing 21 2 3 5
  • Zinc Finger DHHC Domain-Containing Protein 21 3 4
  • DHHC-21 3 4
  • Zinc Finger, DHHC Domain Containing 21 3
  • Probable Palmitoyltransferase ZDHHC21 3
  • Palmitoyltransferase ZDHHC21 3
  • 9130404H11Rik 3
  • EC 2.3.1.225 4
  • EC 2.3.1 61
  • HSPC097 3
  • DHHC21 3
  • DNZ1 3

External Ids for ZDHHC21 Gene

Previous GeneCards Identifiers for ZDHHC21 Gene

  • GC00U907487
  • GC09M014607
  • GC09M014605

Summaries for ZDHHC21 Gene

GeneCards Summary for ZDHHC21 Gene

ZDHHC21 (Zinc Finger DHHC-Type Containing 21) is a Protein Coding gene. Among its related pathways are Metabolism of nitric oxide and Metabolism. GO annotations related to this gene include protein-cysteine S-palmitoyltransferase activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC3.

UniProtKB/Swiss-Prot for ZDHHC21 Gene

  • Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC21 Gene

Genomics for ZDHHC21 Gene

Regulatory Elements for ZDHHC21 Gene

Enhancers for ZDHHC21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ZDHHC21 on UCSC Golden Path with GeneCards custom track

Promoters for ZDHHC21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZDHHC21 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZDHHC21 Gene

Chromosome:
9
Start:
14,555,501 bp from pter
End:
14,693,482 bp from pter
Size:
137,982 bases
Orientation:
Minus strand

Genomic View for ZDHHC21 Gene

Genes around ZDHHC21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC21 Gene

Proteins for ZDHHC21 Gene

  • Protein details for ZDHHC21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVQ6-ZDH21_HUMAN
    Recommended name:
    Palmitoyltransferase ZDHHC21
    Protein Accession:
    Q8IVQ6
    Secondary Accessions:
    • A8KA95
    • D3DRI7
    • Q5VWG1

    Protein attributes for ZDHHC21 Gene

    Size:
    265 amino acids
    Molecular mass:
    31385 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZDHHC21 Gene

Selected DME Specific Peptides for ZDHHC21 Gene

Post-translational modifications for ZDHHC21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZDHHC21 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ZDHHC21 Gene

Gene Families for ZDHHC21 Gene

Protein Domains for ZDHHC21 Gene

Suggested Antigen Peptide Sequences for ZDHHC21 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IVQ6

UniProtKB/Swiss-Prot:

ZDH21_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
  • Contains 1 DHHC domain.
Family:
  • Belongs to the DHHC palmitoyltransferase family.
genes like me logo Genes that share domains with ZDHHC21: view

Function for ZDHHC21 Gene

Molecular function for ZDHHC21 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
UniProtKB/Swiss-Prot Function:
Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity).

Enzyme Numbers (IUBMB) for ZDHHC21 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016409 palmitoyltransferase activity IEA,TAS --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC21: view

Phenotypes for ZDHHC21 Gene

genes like me logo Genes that share phenotypes with ZDHHC21: view

Animal Model Products

CRISPR Products

miRNA for ZDHHC21 Gene

miRTarBase miRNAs that target ZDHHC21

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC21 Gene

Localization for ZDHHC21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC21 Gene

Membrane; Multi-pass membrane protein. Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZDHHC21 Gene COMPARTMENTS Subcellular localization image for ZDHHC21 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZDHHC21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IDA 22031296
GO:0005886 plasma membrane IDA 16647879
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC21: view

Pathways & Interactions for ZDHHC21 Gene

genes like me logo Genes that share pathways with ZDHHC21: view

Pathways by source for ZDHHC21 Gene

Gene Ontology (GO) - Biological Process for ZDHHC21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001942 hair follicle development IEA --
GO:0018230 peptidyl-L-cysteine S-palmitoylation IMP 22031296
GO:0018345 protein palmitoylation IEA,IDA 23034182
GO:0048733 sebaceous gland development IEA --
GO:0050999 regulation of nitric-oxide synthase activity TAS --
genes like me logo Genes that share ontologies with ZDHHC21: view

No data available for SIGNOR curated interactions for ZDHHC21 Gene

Drugs & Compounds for ZDHHC21 Gene

(1) Drugs for ZDHHC21 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for ZDHHC21 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
genes like me logo Genes that share compounds with ZDHHC21: view

Transcripts for ZDHHC21 Gene

Unigene Clusters for ZDHHC21 Gene

Zinc finger, DHHC-type containing 21:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC21 Gene

No ASD Table

Relevant External Links for ZDHHC21 Gene

GeneLoc Exon Structure for
ZDHHC21
ECgene alternative splicing isoforms for
ZDHHC21

Expression for ZDHHC21 Gene

mRNA expression in normal human tissues for ZDHHC21 Gene

Protein differential expression in normal tissues from HIPED for ZDHHC21 Gene

This gene is overexpressed in Islet of Langerhans (55.9) and Fetal heart (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZDHHC21 Gene



Protein tissue co-expression partners for ZDHHC21 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZDHHC21 Gene:

ZDHHC21

SOURCE GeneReport for Unigene cluster for ZDHHC21 Gene:

Hs.649522
genes like me logo Genes that share expression patterns with ZDHHC21: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZDHHC21 Gene

Orthologs for ZDHHC21 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZDHHC21 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZDHHC21 34
  • 95.85 (n)
  • 97.36 (a)
ZDHHC21 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZDHHC21 34
  • 95.72 (n)
  • 97.74 (a)
ZDHHC21 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zdhhc21 34
  • 91.82 (n)
  • 97.74 (a)
Zdhhc21 16
Zdhhc21 35
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC21 34
  • 99.75 (n)
  • 100 (a)
ZDHHC21 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zdhhc21 34
  • 90.82 (n)
  • 97.36 (a)
oppossum
(Monodelphis domestica)
Mammalia ZDHHC21 35
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC21 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZDHHC21 34
  • 80.75 (n)
  • 82.64 (a)
ZDHHC21 35
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZDHHC21 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.18534 34
zdhhc21 34
  • 74.75 (n)
  • 71.97 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30570 34
zebrafish
(Danio rerio)
Actinopterygii zgc:158420 34
  • 65.15 (n)
  • 64.64 (a)
ZDHHC21 35
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Dnz1 35
  • 24 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dhhc-7 35
  • 25 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6666 35
  • 26 (a)
ManyToMany
Species where no ortholog for ZDHHC21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC21 Gene

ENSEMBL:
Gene Tree for ZDHHC21 (if available)
TreeFam:
Gene Tree for ZDHHC21 (if available)

Paralogs for ZDHHC21 Gene

Paralogs for ZDHHC21 Gene

genes like me logo Genes that share paralogs with ZDHHC21: view

Variants for ZDHHC21 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC21 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs7851982 -- 14,650,898(+) TCTCA(C/T)AGCCT intron-variant
rs7852343 -- 14,654,133(+) TAACT(A/G)TAGGG intron-variant
rs7853156 -- 14,654,902(+) agaat(C/T)ccaga intron-variant
rs7857314 -- 14,567,936(+) TCATA(A/G)GACTA intron-variant
rs7859680 -- 14,682,449(+) ggcca(C/T)tacat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC21 Gene

Variant ID Type Subtype PubMed ID
dgv12572n54 CNV loss 21841781
dgv1326e199 CNV deletion 23128226
esv1979971 CNV deletion 18987734
esv2425554 CNV deletion 19546169
esv26384 CNV loss 19812545
esv2738226 CNV deletion 23290073
esv2738227 CNV deletion 23290073
esv2738229 CNV deletion 23290073
esv3544582 CNV deletion 23714750
esv3619752 CNV loss 21293372
nsv1033392 CNV loss 25217958
nsv1075192 CNV deletion 25765185
nsv1115158 CNV deletion 24896259
nsv466260 CNV loss 19166990
nsv471285 CNV loss 18288195
nsv507507 OTHER sequence alteration 20534489
nsv510182 OTHER sequence alteration 20534489
nsv521363 CNV loss 19592680
nsv526219 CNV loss 19592680
nsv613637 CNV gain 21841781
nsv613642 CNV loss 21841781
nsv613643 CNV loss 21841781
nsv613644 CNV loss 21841781
nsv613645 CNV gain 21841781
nsv6482 CNV deletion 18451855
nsv831517 CNV loss 17160897

Variation tolerance for ZDHHC21 Gene

Residual Variation Intolerance Score: 25.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.92; 19.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZDHHC21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZDHHC21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC21 Gene

Disorders for ZDHHC21 Gene

Relevant External Links for ZDHHC21

Genetic Association Database (GAD)
ZDHHC21
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZDHHC21

No disorders were found for ZDHHC21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC21 Gene

Publications for ZDHHC21 Gene

  1. DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors. (PMID: 22031296) Pedram A. … Levin E.R. (Mol. Biol. Cell 2012) 3 4 65
  2. Palmitoylation regulates epidermal homeostasis and hair follicle differentiation. (PMID: 19956733) Mill P. … Jackson I.J. (PLoS Genet. 2009) 2 3 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for ZDHHC21 Gene

Sources for ZDHHC21 Gene

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