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ZDHHC21 Gene

protein-coding   GIFtS: 49
GCID: GC09M014605

Zinc Finger, DHHC-Type Containing 21

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, DHHC-Type Containing 211 2     HSPC0972
Zinc Finger DHHC Domain-Containing Protein 212 3     Palmitoyltransferase ZDHHC212
DHHC-212 3     Probable Palmitoyltransferase ZDHHC212
DHHC212 5     Zinc Finger, DHHC Domain Containing 212
9130404H11Rik2     EC 2.3.1.2253
DNZ12     EC 2.3.18

External Ids:    HGNC: 207501   Entrez Gene: 3404812   Ensembl: ENSG000001758937   OMIM: 6146055   UniProtKB: Q8IVQ63   

Export aliases for ZDHHC21 gene to outside databases

Previous GC identifers: GC00U907487 GC09M014607


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZDHHC21 Gene:
ZDHHC21 (zinc finger, DHHC-type containing 21) is a protein-coding gene. GO annotations related to this gene include palmitoyltransferase activity. An important paralog of this gene is ZDHHC3.

UniProtKB/Swiss-Prot: ZDH21_HUMAN, Q8IVQ6
Function: Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their
targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT
kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008413.19  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZDHHC21 gene promoter:
         Nkx3-1   LHX3b/Lhx3b   Nkx3-1 v4   AML1a   Nkx3-1 v1   LUN-1   RORalpha1   Nkx3-1 v2   Nkx3-1 v3   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZDHHC21 promoter sequence
   Search Chromatin IP Primers for ZDHHC21

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZDHHC21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22.3   Ensembl cytogenetic band:  9p22.3   HGNC cytogenetic band: 9p22.3

ZDHHC21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZDHHC21 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M014605:  view genomic region     (about GC identifiers)

Start:
14,611,069 bp from pter      End:
14,693,480 bp from pter
Size:
82,412 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZDH21_HUMAN, Q8IVQ6 (See protein sequence)
Recommended Name: Palmitoyltransferase ZDHHC21  
Size: 265 amino acids; 31385 Da
Secondary accessions: A8KA95 D3DRI7 Q5VWG1

Explore the universe of human proteins at neXtProt for ZDHHC21: NX_Q8IVQ6

Explore proteomics data for ZDHHC21 at MOPED

3 DME Specific Peptides for ZDHHC21 (Q8IVQ6)
 MDHHCPW  CVRRMDHHC  TDPGRLPENPKIPH 


See ZDHHC21 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_848661.1  
ENSEMBL proteins: 
 ENSP00000370303  
Reactome Protein details: Q8IVQ6

ZDHHC21 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ZDHHC: Zinc fingers, DHHC-type

1 InterPro protein domain:
 IPR001594 Znf_DHHC_palmitoyltrfase

Graphical View of Domain Structure for InterPro Entry Q8IVQ6

ProtoNet protein and cluster: Q8IVQ6

1 Blocks protein domain: IPB001594 Zn-finger

UniProtKB/Swiss-Prot: ZDH21_HUMAN, Q8IVQ6
Domain: The DHHC domain is required for palmitoyltransferase activity (By similarity)
Similarity: Belongs to the DHHC palmitoyltransferase family
Similarity: Contains 1 DHHC-type zinc finger


Find genes that share domains with ZDHHC21           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ZDH21_HUMAN, Q8IVQ6
Function: Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their
targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT
kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity)
Catalytic activity: Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA

     Enzyme Numbers (IUBMB): EC 2.3.1.2251 EC 2.3.12

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008270zinc ion binding IEA--
GO:0016409palmitoyltransferase activity IDA--
GO:0019706protein-cysteine S-palmitoyltransferase activity IEA--
     
Find genes that share ontologies with ZDHHC21           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for ZDHHC21:
 Decreased nuclei size in G2M 

     4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Zdhhc21):
 craniofacial  endocrine/exocrine gland  integument  pigmentation 

Find genes that share phenotypes with ZDHHC21           About GenesLikeMe

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for ZDHHC21

miRNA
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ZDH21_HUMAN, Q8IVQ6: Membrane; Multi-pass membrane protein (Potential). Golgi apparatus (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
golgi apparatus4
plasma membrane3

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000139Golgi membrane TAS--
GO:0005794Golgi apparatus IDA--
GO:0005886plasma membrane IDA16647879
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with ZDHHC21           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ZDHHC21 About    
See pathways by source

SuperPathContained pathways About
1Metabolism of nitric oxide
eNOS activation0.00
eNOS activation and regulation0.00
Metabolism of nitric oxide
2Metabolism
Metabolism0.38


Find genes that share SuperPaths with ZDHHC21           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for ZDHHC21
    eNOS activation


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZDHHC21
Interactions:

    Search GeneGlobe Interaction Network for ZDHHC21

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for ZDHHC21 (Q8IVQ63 ENSP000003703034) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
CREB3O438893I2D: score=1 
GSPT1ENSP000003981314STRING: ENSP00000398131
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Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001942hair follicle development IEA--
GO:0018230peptidyl-L-cysteine S-palmitoylation IMP--
GO:0018345protein palmitoylation IDA--
GO:0044281small molecule metabolic process TAS--
GO:0046209nitric oxide metabolic process TAS--

Find genes that share ontologies with ZDHHC21           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
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Browse Tocris compounds for ZDHHC21 (ZDH21)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ZDHHC21 gene: 
NM_178566.4  

Unigene Cluster for ZDHHC21:

Zinc finger, DHHC-type containing 21
Hs.649522  [show with all ESTs]
Unigene Representative Sequence: AK124263
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000380916(uc003zlg.2 uc003zlh.2) ENST00000497966
miRNA
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SwitchGear 3'UTR luciferase reporter plasmidZDHHC21 3' UTR sequence
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZDHHC21
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  QuantiFast Probe-based Assays in human, mouse, rat ZDHHC21

Additional mRNA sequence: AK124263.1 

1 DOTS entry:

DT.109484 

Selected AceView cDNA sequences (see all 110):

AA456258 CR606494 BF940847 AL539073 AA278314 BX091719 AA489238 AW134761 
BM721007 AA402623 AW468985 AA454645 BQ009516 AI658548 CA431080 BF979691 
CD721770 AK127313 BG564357 AF150301 AA743491 CB160751 AI806563 BM684202 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZDHHC21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
ZDHHC21 Expression
About this image

ZDHHC21 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ZDHHC21 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.649522
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for ZDHHC21 gene from Selected species (see all 16)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Zdhhc211 , 5 zinc finger, DHHC domain containing 211, 5 91.82(n)1
97.74(a)1
  4 (39.40 cM)5
682681  NM_026647.31  NP_080923.21 
 827987385 
chicken
(Gallus gallus)
Aves ZDHHC211 zinc finger, DHHC-type containing 21 80.75(n)
82.64(a)
  427356  NM_001031438.1  NP_001026609.1 
lizard
(Anolis carolinensis)
Reptilia ZDHHC216
zinc finger, DHHC-type containing 21
79(a)
1 ↔ 1
2(34520540-34562348)
African clawed frog
(Xenopus laevis)
Amphibia Xl.305702 Xenopus laevis transcribed sequence 79.11(n)    48046489 
zebrafish
(Danio rerio)
Actinopterygii zgc:1584201 zgc:158420 65.15(n)
64.64(a)
  100144560  NM_001123055.1  NP_001116527.1 
fruit fly
(Drosophila melanogaster)
Insecta Dnz16
DNZDHHC/NEW1 zinc finger protein 11
24(a)
many ↔ many
2L(10854435-10856644)
worm
(Caenorhabditis elegans)
Secernentea dhhc-76
Protein DHHC-7, isoform a
25(a)
many ↔ many
I(11611672-11616139) WBGene00007637


ENSEMBL Gene Tree for ZDHHC21 (if available)
TreeFam Gene Tree for ZDHHC21 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ZDHHC21 gene
ZDHHC32  ZDHHC72  ZDHHC202  ZDHHC162  ZDHHC62  ZDHHC22  ZDHHC152  

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZDHHC21 (see all 2111)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1816670011,2
--14610571(+) ACTCAC/TTGTCT 1 -- ds50010--------
rs13437061,2
C,F,O,A,H--14610591(+) GCTGAT/CTGATT 1 -- ds500122Minor allele frequency- C:0.33NA NS EA WA 2484
rs1863353551,2
C--14610625(+) TTTTTA/GGCCAA 1 -- ds50010--------
rs13437051,2
C,F,O,A,H--14610866(+) TTTCAA/GCCCTA 1 -- ds500130Minor allele frequency- G:0.30EA NA NS WA CSA 2974
rs1164916041,2
C,F--14610920(+) ATTATG/AGCAGA 1 -- ds50011Minor allele frequency- A:0.05WA 118
rs1912335711,2
--14610938(+) CCTAAC/GGCTAG 1 -- ds50010--------
rs1436598761,2
--14610972(+) TGTATA/CAAATT 1 -- ds50010--------
rs1383592101,2
--14610981(+) TTTTTA/CAAAGT 1 -- ds50010--------
rs169320561,2
C,F--14611025(+) TTTGGG/TTTAAT 1 -- ds50015Minor allele frequency- T:0.05NA WA 262
rs126827371,2
H--14611066(+) AACAGT/ACCTAC 1 -- ds50014Minor allele frequency- A:0.00NS EA 412

HapMap Linkage Disequilibrium report for ZDHHC21 (14611069 - 14693480 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for ZDHHC21 (see all 21):    About this table    
Variant IDTypeSubtypePubMed ID
esv2425554CNV Deletion19546169
esv1979971CNV Deletion18987734
esv2738226CNV Deletion23290073
esv2738227CNV Deletion23290073
esv2738229CNV Deletion23290073
dgv1326e199CNV Deletion23128226
nsv507507CNV Insertion20534489
nsv466260CNV Loss19166990
nsv521363CNV Loss19592680
dgv8108n71CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 614605    OMIM disorders: --


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Genetic Association Database (GAD): ZDHHC21

Export disorders for ZDHHC21 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ZDHHC21 gene, integrated from 10 sources (see all 14):
(articles sorted by number of sources associating them with ZDHHC21)
    Utopia: connect your pdf to the dynamic
world of online information

  1. DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors. (PubMed id 22031296)1, 2 Pedram A.... Levin E.R. (Mol. Biol. Cell 2012)
  2. Palmitoylation regulates epidermal homeostasis and hair follicle differentiation. (PubMed id 19956733)1, 3 Mill P....Jackson I.J. (PLoS Genet. 2009)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
  6. Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases. (PubMed id 22496122)1 Marin E.P....Sessa W.C. (Circ. Res. 2012)
  7. Novel associations for hypothyroidism include known autoimmune risk loci. (PubMed id 22493691)1 Eriksson N....Do C.B. (PLoS ONE 2012)
  8. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (PLoS Genet. 2012)
  9. Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03). (PubMed id 19754311)1 Le Clerc S....Zagury J.F. (J. Infect. Dis. 2009)
  10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 340481 HGNC: 20750 AceView: ZDHHC21 Ensembl:ENSG00000175893 euGenes: HUgn340481
ECgene: ZDHHC21 H-InvDB: ZDHHC21

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ZDHHC21 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ZDHHC21 gene:
Search GeneIP for patents involving ZDHHC21

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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