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Aliases for ZDHHC20 Gene

Aliases for ZDHHC20 Gene

  • Zinc Finger, DHHC-Type Containing 20 2 3
  • Zinc Finger DHHC Domain-Containing Protein 20 3 4
  • DHHC-20 3 4
  • 4933421L13Rik 3
  • EC 2.3.1.225 4
  • EC 2.3.1 63

External Ids for ZDHHC20 Gene

Previous GeneCards Identifiers for ZDHHC20 Gene

  • GC00U907486
  • GC13M020845
  • GC13M020826
  • GC13M021950
  • GC13M002751

Summaries for ZDHHC20 Gene

GeneCards Summary for ZDHHC20 Gene

ZDHHC20 (Zinc Finger, DHHC-Type Containing 20) is a Protein Coding gene. GO annotations related to this gene include protein-cysteine S-palmitoyltransferase activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC7.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC20 Gene

Genomics for ZDHHC20 Gene

Regulatory Elements for ZDHHC20 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZDHHC20 Gene

Chromosome:
13
Start:
21,372,571 bp from pter
End:
21,459,370 bp from pter
Size:
86,800 bases
Orientation:
Minus strand

Genomic View for ZDHHC20 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZDHHC20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC20 Gene

Proteins for ZDHHC20 Gene

  • Protein details for ZDHHC20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5W0Z9-ZDH20_HUMAN
    Recommended name:
    Probable palmitoyltransferase ZDHHC20
    Protein Accession:
    Q5W0Z9
    Secondary Accessions:
    • A8MTV9
    • C9JG20
    • I6L9D4
    • Q2TB82
    • Q6NVU8

    Protein attributes for ZDHHC20 Gene

    Size:
    365 amino acids
    Molecular mass:
    42278 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZDHHC20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZDHHC20 Gene

Proteomics data for ZDHHC20 Gene at MOPED

Selected DME Specific Peptides for ZDHHC20 Gene

Post-translational modifications for ZDHHC20 Gene

  • Ubiquitination at Lys 96 and Lys 123
  • Modification sites at PhosphoSitePlus

Other Protein References for ZDHHC20 Gene

Domains & Families for ZDHHC20 Gene

Gene Families for ZDHHC20 Gene

Protein Domains for ZDHHC20 Gene

Graphical View of Domain Structure for InterPro Entry

Q5W0Z9

UniProtKB/Swiss-Prot:

ZDH20_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
  • Contains 1 DHHC-type zinc finger.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family.
Similarity:
  • Contains 1 DHHC-type zinc finger.
genes like me logo Genes that share domains with ZDHHC20: view

Function for ZDHHC20 Gene

Molecular function for ZDHHC20 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA

Enzyme Numbers (IUBMB) for ZDHHC20 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016409 palmitoyltransferase activity IDA 23034182
GO:0019706 protein-cysteine S-palmitoyltransferase activity IBA --
genes like me logo Genes that share ontologies with ZDHHC20: view
genes like me logo Genes that share phenotypes with ZDHHC20: view

Animal Model Products

CRISPR Products

miRNA for ZDHHC20 Gene

miRTarBase miRNAs that target ZDHHC20

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZDHHC20

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC20 Gene

Localization for ZDHHC20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC20 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZDHHC20 Gene COMPARTMENTS Subcellular localization image for ZDHHC20 gene
Compartment Confidence
plasma membrane 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for ZDHHC20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA --
GO:0005794 Golgi apparatus IBA --
GO:0005886 plasma membrane IDA 16647879
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC20: view

Pathways & Interactions for ZDHHC20 Gene

SuperPathways for ZDHHC20 Gene

No Data Available

Interacting Proteins for ZDHHC20 Gene

Gene Ontology (GO) - Biological Process for ZDHHC20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006612 protein targeting to membrane IBA --
GO:0008152 metabolic process --
GO:0018230 peptidyl-L-cysteine S-palmitoylation IBA --
GO:0018345 protein palmitoylation IDA 23034182
genes like me logo Genes that share ontologies with ZDHHC20: view

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC20 Gene

Drugs & Compounds for ZDHHC20 Gene

(1) Drugs for ZDHHC20 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for ZDHHC20 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
genes like me logo Genes that share compounds with ZDHHC20: view

Transcripts for ZDHHC20 Gene

Unigene Clusters for ZDHHC20 Gene

Zinc finger, DHHC-type containing 20:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZDHHC20

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC20 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1: -
SP2: -
SP3: - - - -
SP4: - - -
SP5: - -
SP6: -

Relevant External Links for ZDHHC20 Gene

GeneLoc Exon Structure for
ZDHHC20
ECgene alternative splicing isoforms for
ZDHHC20

Expression for ZDHHC20 Gene

mRNA expression in normal human tissues for ZDHHC20 Gene

mRNA differential expression in normal tissues according to GTEx for ZDHHC20 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.5).

Protein differential expression in normal tissues from HIPED for ZDHHC20 Gene

This gene is overexpressed in Nasal epithelium (41.3) and Breast (16.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZDHHC20 Gene



SOURCE GeneReport for Unigene cluster for ZDHHC20 Gene Hs.564611

genes like me logo Genes that share expression patterns with ZDHHC20: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZDHHC20 Gene

Orthologs for ZDHHC20 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZDHHC20 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZDHHC20 35
  • 91.69 (n)
  • 92.38 (a)
ZDHHC20 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZDHHC20 35
  • 93.5 (n)
  • 94.35 (a)
ZDHHC20 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zdhhc20 35
  • 89.99 (n)
  • 92.07 (a)
Zdhhc20 16
Zdhhc20 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC20 35
  • 99.44 (n)
  • 99.72 (a)
ZDHHC20 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zdhhc20 35
  • 90.45 (n)
  • 91.98 (a)
oppossum
(Monodelphis domestica)
Mammalia ZDHHC20 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC20 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZDHHC20 35
  • 78.74 (n)
  • 79.49 (a)
ZDHHC20 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZDHHC20 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc20 35
  • 70.09 (n)
  • 72.93 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:162723 35
  • 64.07 (n)
  • 67.66 (a)
ZDHHC20 (1 of 2) 36
  • 63 (a)
OneToMany
ZDHHC20 (2 of 2) 36
  • 58 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004938 35
  • 53.99 (n)
  • 50.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1407 35
  • 53.79 (n)
  • 53.45 (a)
CG1407 36
  • 37 (a)
ManyToMany
CG17287 36
  • 36 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dhhc-4 36
  • 32 (a)
ManyToMany
spe-10 36
  • 31 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PFA3 36
  • 27 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons SMO1-3 35
  • 48.64 (n)
  • 37.41 (a)
rice
(Oryza sativa)
Liliopsida Os10g0545200 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for ZDHHC20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC20 Gene

ENSEMBL:
Gene Tree for ZDHHC20 (if available)
TreeFam:
Gene Tree for ZDHHC20 (if available)

Paralogs for ZDHHC20 Gene

Paralogs for ZDHHC20 Gene

(2) SIMAP similar genes for ZDHHC20 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ZDHHC20 Gene

genes like me logo Genes that share paralogs with ZDHHC20: view

Variants for ZDHHC20 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC20 Gene

Variant ID Type Subtype PubMed ID
esv992961 CNV Insertion 20482838
esv28175 CNV Loss 19812545
esv2668027 CNV Deletion 23128226
esv1388531 CNV Insertion 17803354

Variation tolerance for ZDHHC20 Gene

Residual Variation Intolerance Score: 58.71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZDHHC20 Gene

HapMap Linkage Disequilibrium report
ZDHHC20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for ZDHHC20 Gene

Disorders for ZDHHC20 Gene

Relevant External Links for ZDHHC20

Genetic Association Database (GAD)
ZDHHC20
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZDHHC20
genes like me logo Genes that share disorders with ZDHHC20: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC20 Gene

Publications for ZDHHC20 Gene

  1. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  2. Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. (PMID: 23400010) Del-Aguila J.L. … Boerwinkle E. (Pharmacogenomics J. 2013) 67
  3. Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system. (PMID: 23034182) Ohno Y. … Kihara A. (Mol. Biol. Cell 2012) 67
  4. Defining the membrane proteome of NK cells. (PMID: 19946888) Ghosh D. … Wilkins J.A. (J Mass Spectrom 2010) 67
  5. DHHC20: a human palmitoyl acyltransferase that causes cellular transformation. (PMID: 20334580) Draper J.M. … Smith C.D. (Mol. Membr. Biol. 2010) 67

Products for ZDHHC20 Gene

Sources for ZDHHC20 Gene

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