ZDHHC20 Gene
protein-coding GIFtS: 46
GCID: GC13M021950
|
|
zinc finger, DHHC-type containing 20
| |
Aliases
for ZDHHC20 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger, DHHC-Type Containing 201 2 | | DHHC-Containing Protein 202 | | Zinc Finger DHHC Domain-Containing Protein 202 3 | | Probable Palmitoyltransferase ZDHHC202 | | DHHC-202 3 | | Zinc Finger, DHHC Domain Containing 202 | | FLJ259521 | | EC 2.3.1.-3 | | 4933421L13Rik2 | | EC 2.3.18 |
Export aliases for ZDHHC20 gene to outside databasesPrevious GC identifers: GC00U907486 GC13M020845 GC13M020826 GC13M002751 |
Summaries
for ZDHHC20 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ZDHHC20 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZDHHC20 gene promoter:
STAT1 Pax-5 HOXA3 Pbx1a GATA-3 STAT1beta XBP-1 STAT1alpha PPAR-alpha E2F-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZDHHC20
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZDHHC20 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q12.11 Ensembl cytogenetic band: 13q12.11 HGNC cytogenetic band: 13q12.11ZDHHC20 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13M021950: view genomic region
(about GC identifiers)
Start:
|
21,950,263 bp from pter |
End:
|
22,033,509 bp from pter |
Size:
|
83,247 bases |
Orientation:
|
minus strand |
|
Proteins
for ZDHHC20 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZDH20_HUMAN, Q5W0Z9 (See
protein sequence)Recommended Name: Probable palmitoyltransferase ZDHHC20 Size: 365 amino acids; 42278 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: A8MTV9 C9JG20 Q6NVU8Alternative splicing: 3 isoforms: Q5W0Z9-1 Q5W0Z9-2 Q5W0Z9-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZDHHC20: NX_Q5W0Z9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5W0Z9
4/6 DME Specific Peptides for ZDHHC20 (Q5W0Z9) (see all 6)
ZDHHC20 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_694983.2
ENSEMBL proteins: ENSP00000383433 ENSP00000371905 ENSP00000443236 ENSP00000401232 ENSP00000313583 ENSP00000396819
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
ZDHHC20 for ontologies About GeneDecksing
ZDHHC20 Antibody Products:
Assay Products for ZDHHC20: |
Protein
Domains /
Families
for ZDHHC20 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZDHHC20 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5W0Z9ProtoNet protein and cluster: Q5W0Z9 1 Blocks protein family: IPB001594 Zn-finger
UniProtKB/Swiss-Prot: ZDH20_HUMAN, Q5W0Z9Domain: The DHHC domain is required for palmitoyltransferase activity (By similarity)Similarity: Belongs to the DHHC palmitoyltransferase familySimilarity: Contains 1 DHHC-type zinc finger |
Function
for ZDHHC20 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZDH20_HUMAN, Q5W0Z9Catalytic activity: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoAEnzyme Numbers (IUBMB): EC 2.3.12 EC 2.3.1.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC20 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC20
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: ZDHHC20 (NM_153251) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC20 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- | | GO:0016740 | transferase activity |
-- | -- | | GO:0016746 | transferase activity, transferring acyl groups |
IEA | -- |
ZDHHC20 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for ZDHHC20:
|
Pathways & Interactions
for ZDHHC20 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZDHHC20
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ZDHHC20 (ENSP000003719054) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for ZDHHC20 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZDHHC20
Search CenterWatch for drugs/clinical trials and news about ZDHHC20 / ZDH20
|
Transcripts
for ZDHHC20 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZDHHC20 gene: NM_153251.3 Unigene Cluster for ZDHHC20: Zinc finger, DHHC-type containing 20 Hs.564611 [show with all ESTs]Unigene Representative Sequence: NM_15325110 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000400590(uc001uoa.2 uc001uod.3 uc001uoc.3 uc001uoe.3 uc010tcs.2)
ENST00000464055 ENST00000477811 ENST00000494731 ENST00000484277 ENST00000382466
ENST00000542645 ENST00000415724 ENST00000320220 ENST00000422251
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC20 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC20
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZDHHC20 (NM_153251) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZDHHC20 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZDHHC20 |
Additional cDNA sequence: AK090979.1 AK299354.1 AL833626.1 BC034944.1 BC036691.1 BC037336.1 BC050367.1 15 DOTS entries: DT.75166788 DT.100784012 DT.120784063 DT.116238 DT.101962807 DT.101979037 DT.75149530 DT.120784460 DT.100725915 DT.95363371 DT.100724784 DT.120783856 DT.120784025 DT.100690507 DT.120784392 24/171 AceView cDNA sequences (see all 171): AI640293 AI191266 NM_153251 AA383635 BG571281 BM807303 BX480028 CA446645 BE463631 AL833626 BM556200 R71043 AA731630 AA454190 BM126922 AA765809 BE350064 BC034944 BX490149 AK090979 AI951066 BC050367 AA827058 BM126657
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC20 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | · | 15c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | | | - | | | | | | - | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | - | | | | | | | | |
| SP5: | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZDHHC20
|
Expression
for ZDHHC20 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZDHHC20 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACACAGAAC
About this image
See ZDHHC20 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZDHHC20
SOURCE GeneReport for Unigene cluster: Hs.564611
SABiosciences Custom PCR Arrays for ZDHHC20
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZDHHC20
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZDHHC20 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZDHHC20 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZDHHC20 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC20 |
Orthologs
for ZDHHC20 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ZDHHC20 gene from 7/27 species (see all 27) About this table
ENSEMBL Gene Tree for ZDHHC20 (if available)
TreeFam Gene Tree for ZDHHC20 (if available) |
Paralogs
for ZDHHC20 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZDHHC20 gene
- ZDHHC212 ZDHHC32 ZDHHC72 ZDHHC232 ZDHHC152 ZDHHC22
18/47 SIMAP similar genes for ZDHHC20 using alignment to 6 protein entries: ZDH20_HUMAN (see all proteins)
(see all similar genes):CHID1 DCTN5 A4GALT SHANK2 C4orf21 NF2
FAM210A TNFRSF17 ZDHHC2 RNF217 ERBB2 LYRM4
QRICH2 RBMS2 SNX31 PKN1 ZDHHC15 CATSPERG
ZDHHC20 for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for ZDHHC20
PGOHUM00000242372 PGOHUM00000248624 PGOHUM00000243125 PGOHUM00000243583
|
Genomic Variants
for ZDHHC20 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZDHHC20 (21950263 - 22033509 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for ZDHHC20
3 CNVs: 76270 76269 86727
3 Indels: 71689 86728 86729 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZDHHC20 |
|
Disorders
/ Diseases
for ZDHHC20 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZDHHC20 for disorders About GeneDecksing
1  disease for ZDHHC20: About MalaCardsmalaria
Export disorders for ZDHHC20 gene to outside databases
|
Publications
for ZDHHC20 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZDHHC20 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with ZDHHC20) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- DHHC20: a human palmitoyl acyltransferase that causes cellular transformation. (PubMed id 20334580)1 Draper J.M. and Smith C.D. (2010)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)2 Matsuoka S.... Elledge S.J. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZDHHC20 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZDHHC20 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZDHHC20 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZDHHC20 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZDHHC20 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZDHHC20 gene:
Search GeneIP for patents involving ZDHHC20
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZDHHC20 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC20 |
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