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ZDHHC2 Gene

protein-coding   GIFtS: 52
GCID: GC08P017058

Zinc Finger, DHHC-Type Containing 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, DHHC-Type Containing 21 2     rec2
Reduced Expression Associated With Metastasis Protein2 3     Zinc Finger, DHHC Domain Containing 22
Reduced Expression In Cancer Protein2 3     EC 2.3.1.2253
Zinc Finger DHHC Domain-Containing Protein 22 3     REAM3
Zinc Finger Protein 3722 3     REC3
DHHC-22 3     Ream3
ZNF3722 3     Rec3
DHHC22     DHHC215
Palmitoyltransferase ZDHHC22     ZDHHC215
ream2     EC 2.3.18

External Ids:    HGNC: 184691   Entrez Gene: 512012   Ensembl: ENSG000001042197   OMIM: 6146055   UniProtKB: Q9UIJ53   

Export aliases for ZDHHC2 gene to outside databases

Previous GC identifers: GC08P016907 GC08P017093 GC08P017024 GC08P017023 GC08P015559


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZDHHC2 Gene:
ZDHHC2 (zinc finger, DHHC-type containing 2) is a protein-coding gene. Diseases associated with ZDHHC2 include chronic interstitial cystitis, and cystitis. GO annotations related to this gene include palmitoyltransferase activity. An important paralog of this gene is ZDHHC21.

UniProtKB/Swiss-Prot: ZDHC2_HUMAN, Q9UIJ5
Function: Palmitoyltransferase specific for GAP43 and DLG4/PSD95 (By similarity)

Gene Wiki entry for ZDHHC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ZDHHC2 gene promoter:
         GATA-3   AP-1   ATF-2   MEF-2A   POU2F1   POU2F1a   c-Jun   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZDHHC2 promoter sequence
   Search Chromatin IP Primers for ZDHHC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZDHHC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p22   Ensembl cytogenetic band:  8p22   HGNC cytogenetic band: 8p22

ZDHHC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZDHHC2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P017058:  view genomic region     (about GC identifiers)

Start:
17,013,538 bp from pter      End:
17,082,308 bp from pter
Size:
68,771 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZDHC2_HUMAN, Q9UIJ5 (See protein sequence)
Recommended Name: Palmitoyltransferase ZDHHC2  
Size: 367 amino acids; 42022 Da
Secondary accessions: D3DSP5

Explore the universe of human proteins at neXtProt for ZDHHC2: NX_Q9UIJ5

Explore proteomics data for ZDHHC2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ZDHHC2 (Q9UIJ5) (see all 5)
     MDHHCPW  CILKMDH  NYKFFLLFL  KPDRCHHCS 


    See ZDHHC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057437.1  
    ENSEMBL proteins: 
     ENSP00000262096   ENSP00000430804   ENSP00000430317  

    ZDHHC2 Human Recombinant Protein Products:

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    Novus Biologicals ZDHHC2 Lysate
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    Cloud-Clone Corp. Proteins for ZDHHC2

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    Cloud-Clone Corp. CLIAs for ZDHHC2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZDHHC: Zinc fingers, DHHC-type

    1 InterPro protein domain:
     IPR001594 Znf_DHHC_palmitoyltrfase

    Graphical View of Domain Structure for InterPro Entry Q9UIJ5

    ProtoNet protein and cluster: Q9UIJ5

    1 Blocks protein domain: IPB001594 Zn-finger

    UniProtKB/Swiss-Prot: ZDHC2_HUMAN, Q9UIJ5
    Domain: The DHHC domain is required for palmitoyltransferase activity (By similarity)
    Similarity: Belongs to the DHHC palmitoyltransferase family
    Similarity: Contains 1 DHHC-type zinc finger


    ZDHHC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZDHC2_HUMAN, Q9UIJ5
    Function: Palmitoyltransferase specific for GAP43 and DLG4/PSD95 (By similarity)
    Catalytic activity: Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA

         Enzyme Numbers (IUBMB): EC 2.3.1.2251 EC 2.3.12

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
    GO:0008270zinc ion binding IEA--
    GO:0016409palmitoyltransferase activity IDA--
    GO:0019706protein-cysteine S-palmitoyltransferase activity IEA--
         
    ZDHHC2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZDHHC2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZDHHC2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZDHHC2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZDHHC2

    miRNA
    Products:
        
    miRTarBase miRNAs that target ZDHHC2:
    hsa-mir-192-5p (MIRT026589), hsa-mir-215-5p (MIRT024885), hsa-mir-132-3p (MIRT021821)

    Block miRNA regulation of human, mouse, rat ZDHHC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZDHHC2 (see all 34):
    hsa-miR-3152-3p hsa-miR-300 hsa-miR-219-5p hsa-miR-301a hsa-miR-624 hsa-miR-218 hsa-miR-374c hsa-miR-548m
    SwitchGear 3'UTR luciferase reporter plasmidZDHHC2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ZDHHC2
    Predesigned siRNA for gene silencing in human, mouse, rat ZDHHC2

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for ZDHHC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZDHHC2 (NM_016353)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZDHHC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZDHHC2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ZDHHC2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZDHC2_HUMAN, Q9UIJ5: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular2
    golgi apparatus2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA16647879
    GO:0005794Golgi apparatus IDA16647879
    GO:0005887integral component of plasma membrane IEA--
    GO:0016020membrane ----
    GO:0055038recycling endosome membrane IEA--

    ZDHHC2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZDHHC2
    Interactions:

        Search GeneGlobe Interaction Network for ZDHHC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for ZDHHC2 (Q9UIJ53 ENSP000002620964) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TMEM35Q53FP23, ENSP000003620214I2D: score=1 STRING: ENSP00000362021
    MAFBQ9Y5Q33, ENSP000003624104I2D: score=1 STRING: ENSP00000362410
    MSX2P355483, ENSP000002392434I2D: score=1 STRING: ENSP00000239243
    DLG4P783523I2D: score=1 
    CTNNB1ENSP000003444564STRING: ENSP00000344456
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development ----
    GO:0018345protein palmitoylation IDA--

    ZDHHC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZDHHC2 (ZDHC2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZDHHC2 gene: 
    NM_016353.4  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262096(uc003wxe.3) ENST00000523132 ENST00000522184 ENST00000517334

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZDHHC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZDHHC2 (see all 34):
    hsa-miR-3152-3p hsa-miR-300 hsa-miR-219-5p hsa-miR-301a hsa-miR-624 hsa-miR-218 hsa-miR-374c hsa-miR-548m
    SwitchGear 3'UTR luciferase reporter plasmidZDHHC2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZDHHC2
    Predesigned siRNA for gene silencing in human, mouse, rat ZDHHC2
    Clone
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    OriGene clones in human, mouse for ZDHHC2 (see all 7)
    OriGene ORF clones in mouse, rat for ZDHHC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZDHHC2 (NM_016353)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZDHHC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZDHHC2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ZDHHC2
    OriGene qSTAR qPCR primer pairs in human, mouse for ZDHHC2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZDHHC2
      QuantiTect SYBR Green Assays in human, mouse, rat ZDHHC2
      QuantiFast Probe-based Assays in human, mouse, rat ZDHHC2

    Selected AceView cDNA sequences (see all 129):

    AU130929 AI337674 AI624599 BI468563 AI123822 AA781969 BU735507 AW440609 
    CR591508 AB023584 CB109103 AI688634 AL556978 BX500113 CR626790 AA461348 
    AW614265 BM128097 AI207121 AL597207 AL043103 CR598335 BE671069 AI619547 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:        -                                                     -                                 
    SP2:                                                              -           -                     
    SP3:                                                                                                
    SP4:                                                                                                


    ECgene alternative splicing isoforms for ZDHHC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZDHHC2 expression in normal human tissues (normalized intensities)      ZDHHC2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTCACTCC
    ZDHHC2 Expression
    About this image


    ZDHHC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 27 entries
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
             Thalamus
             nerve/cranial/vestibulocochlear VIII   
     
     Neurons
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Pre-Sertoli Cells Testis Cord
     
     Spinal Cord (Nervous System)
    ZDHHC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZDHHC2 Protein Expression

    UniProtKB/Swiss-Prot: ZDHC2_HUMAN, Q9UIJ5
    Tissue specificity: Ubiquitously expressed. Reduced expression in colorectal cancers with liver metastasis

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ZDHHC2 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zdhhc21 , 5 zinc finger, DHHC domain containing 21, 5 91.35(n)1
    95.36(a)1
      8 (23.89 cM)5
    705461  NM_178395.31  NP_848482.11 
     404238155 
    chicken
    (Gallus gallus)
    Aves ZDHHC21 zinc finger, DHHC-type containing 2 81.19(n)
    84.66(a)
      422734  XM_420689.4  XP_420689.4 
    lizard
    (Anolis carolinensis)
    Reptilia ZDHHC26
    zinc finger, DHHC-type containing 2
    73(a)
    1 ↔ 1
    5(108169808-108205853)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.191302 Xenopus laevis transcribed sequence with moderate similarity more 82.09(n)    BJ066084.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zdhhc21 zinc finger, DHHC-type containing 2 69.81(n)
    75.83(a)
      541365  NM_001013492.1  NP_001013510.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG14073   -- 50(a)
    (best of 2)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea ZK757.13
    ZK757.41
    ZK757.41 38(a)3
    50.45(n)1
    48.65(a)1
      III(9936543-9942821)3
    131909521  NM_001268109.11  NP_001255038.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PFA36
    Palmitoyltransferase for Vac8p, required for vacuo...
    26(a)
    1 → many
    XIV(27337-28347) YNL326C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G008401 AT4G00840 48.93(n)
    36.6(a)
      826193  NM_116310.4  NP_567193.2 


    ENSEMBL Gene Tree for ZDHHC2 (if available)
    TreeFam Gene Tree for ZDHHC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZDHHC2 gene
    ZDHHC212  ZDHHC32  ZDHHC72  ZDHHC202  ZDHHC162  ZDHHC62  ZDHHC152  
    9 SIMAP similar genes for ZDHHC2 using alignment to 2 protein entries:     ZDHC2_HUMAN (see all proteins):
    ZDHHC3    ZDHHC20    ZDHHC14    ZDHHC5    ZDHHC15    ZDHHC18
    ZDHHC7    ZDHHC1    ZDHHC8

    ZDHHC2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZDHHC2 (see all 1739)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0152304
    A colorectal cancer sample4--see VAR_0152302 M I mis40--------
    VAR_0152294
    A hepatocellular carcinoma sample4--see VAR_0152292 S F mis40--------
    rs1923957901,2
    --17011864(+) GAAAAG/TAAATC 1 -- us2k10--------
    rs284885591,2
    C--17011868(+) ATAAAC/TCAAAG 1 -- us2k10--------
    rs1849893121,2
    --17011902(+) GCTCTC/TCTTCC 1 -- us2k10--------
    rs1889782041,2
    --17011990(+) TTAGAA/GACTAC 1 -- us2k10--------
    rs1468999471,2
    --17012188(+) TAGATA/GAGTAA 1 -- us2k10--------
    rs1818557911,2
    --17012219(+) AGATAC/TGACAC 1 -- us2k10--------
    rs29046581,2
    C,F,A,H--17012250(+) GTAGAC/TGATGT 1 -- us2k114Minor allele frequency- T:0.24NS EA NA WA 790
    rs1479643781,2
    --17012263(+) AAACTC/GGGCAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZDHHC2 (17013538 - 17082308 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ZDHHC2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2736686CNV Deletion23290073
    esv1030364CNV Deletion17803354
    esv2736683CNV Deletion23290073
    esv2736685CNV Deletion23290073
    nsv890555CNV Loss21882294
    nsv831244CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614605    OMIM disorders: --

    UniProtKB/Swiss-Prot: ZDHC2_HUMAN, Q9UIJ5
  • Note=Mutations in ZDHHC2 are found in hepatocellular carcinoma and colorectal cancer

  • 9 diseases for ZDHHC2:    About MalaCards
    chronic interstitial cystitis    cystitis    gastric adenocarcinoma    colorectal cancer
    hepatocellular carcinoma    adenocarcinoma    multiple myeloma    myeloma
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for ZDHHC2:
    Interstitial cystitis

    ZDHHC2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZDHHC2
    Human Genome Epidemiology (HuGE) Navigator: ZDHHC2 (1 document)

    Export disorders for ZDHHC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZDHHC2 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with ZDHHC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a novel gene on 8p21.3-22 whose expression is reduced significantly in human colorectal cancers with liver metastasis. (PubMed id 10918388)1, 2, 3 Oyama T.... Nakamura Y. (Genes Chromosomes Cancer 2000)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Reduced expression of ZDHHC2 is associated with lymph node metastasis and poor prognosis in gastric adenocarcinoma. (PubMed id 23457560)1 Yan S.M....Du Z.M. (PLoS ONE 2013)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. The palmitoyl transferase DHHC2 targets a dynamic membrane cycling pathway: regulation by a C-terminal domain. (PubMed id 21471008)1 Greaves J....Chamberlain L.H. (Mol. Biol. Cell 2011)
    7. DHHC2 is a protein S-acyltransferase for Lck. (PubMed id 22034844)1 Zeidman R....Magee A.I. (Mol. Membr. Biol. 2011)
    8. Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein. (PubMed id 21343290)1 Jia L....Blumer K.J. (J. Biol. Chem. 2011)
    9. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)
    10. Palmitoylation of cytoskeleton associated protein 4 by DHHC2 regulates antiproliferative factor-mediated signaling. (PubMed id 19144824)1 Planey S.L.... Zacharias D.A. (Mol. Biol. Cell 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51201 HGNC: 18469 AceView: ZDHHC2 Ensembl:ENSG00000104219 euGenes: HUgn51201
    ECgene: ZDHHC2 H-InvDB: ZDHHC2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZDHHC2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ZDHHC2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZDHHC2 gene:
    Search GeneIP for patents involving ZDHHC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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