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Aliases for ZDHHC2 Gene

Aliases for ZDHHC2 Gene

  • Zinc Finger, DHHC-Type Containing 2 2 3
  • Reduced Expression Associated With Metastasis Protein 3 4
  • Zinc Finger DHHC Domain-Containing Protein 2 3 4
  • Reduced Expression In Cancer Protein 3 4
  • Zinc Finger Protein 372 3 4
  • DHHC-2 3 4
  • ZNF372 3 4
  • Ream 3 4
  • Rec 3 4
  • Zinc Finger, DHHC Domain Containing 2 3
  • Palmitoyltransferase ZDHHC2 3
  • EC 4
  • EC 2.3.1 63
  • ZDHHC21 6
  • DHHC21 6
  • DHHC2 3

External Ids for ZDHHC2 Gene

Previous GeneCards Identifiers for ZDHHC2 Gene

  • GC08P016907
  • GC08P017093
  • GC08P017024
  • GC08P017023
  • GC08P017058
  • GC08P015559

Summaries for ZDHHC2 Gene

GeneCards Summary for ZDHHC2 Gene

ZDHHC2 (Zinc Finger, DHHC-Type Containing 2) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism of nitric oxide. GO annotations related to this gene include palmitoyltransferase activity. An important paralog of this gene is ZDHHC7.

UniProtKB/Swiss-Prot for ZDHHC2 Gene

  • Palmitoyltransferase specific for GAP43 and DLG4/PSD95.

Gene Wiki entry for ZDHHC2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC2 Gene

Genomics for ZDHHC2 Gene

Regulatory Elements for ZDHHC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZDHHC2 Gene

17,156,029 bp from pter
17,224,965 bp from pter
68,937 bases
Plus strand

Genomic View for ZDHHC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZDHHC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC2 Gene

Proteins for ZDHHC2 Gene

  • Protein details for ZDHHC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Palmitoyltransferase ZDHHC2
    Protein Accession:
    Secondary Accessions:
    • D3DSP5

    Protein attributes for ZDHHC2 Gene

    367 amino acids
    Molecular mass:
    42022 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZDHHC2 Gene

Proteomics data for ZDHHC2 Gene at MOPED

Selected DME Specific Peptides for ZDHHC2 Gene

Post-translational modifications for ZDHHC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZDHHC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains for ZDHHC2 Gene

Gene Families for ZDHHC2 Gene

  • ZDHHC :Zinc fingers, DHHC-type

Protein Domains for ZDHHC2 Gene

Suggested Antigen Peptide Sequences for ZDHHC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9UIJ5
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
  • Contains 1 DHHC-type zinc finger.
genes like me logo Genes that share domains with ZDHHC2: view

Function for ZDHHC2 Gene

Molecular function for ZDHHC2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA
UniProtKB/Swiss-Prot Function:
Palmitoyltransferase specific for GAP43 and DLG4/PSD95.

Enzyme Numbers (IUBMB) for ZDHHC2 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity --
GO:0008270 zinc ion binding IEA --
GO:0016409 palmitoyltransferase activity IDA 23034182
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC2: view

Animal Model Products

miRNA for ZDHHC2 Gene

miRTarBase miRNAs that target ZDHHC2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZDHHC2

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZDHHC2 Gene

Localization for ZDHHC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ZDHHC2 Gene COMPARTMENTS Subcellular localization image for ZDHHC2 gene
Compartment Confidence
plasma membrane 3
extracellular 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for ZDHHC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 16647879
GO:0005794 Golgi apparatus IDA 16647879
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane --
GO:0055038 recycling endosome membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC2: view

Pathways for ZDHHC2 Gene

genes like me logo Genes that share pathways with ZDHHC2: view

Pathways by source for ZDHHC2 Gene

Gene Ontology (GO) - Biological Process for ZDHHC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development --
GO:0018345 protein palmitoylation IDA 23034182
genes like me logo Genes that share ontologies with ZDHHC2: view

Transcripts for ZDHHC2 Gene

Unigene Clusters for ZDHHC2 Gene

Zinc finger, DHHC-type containing 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZDHHC2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: - -
SP2: - -

Relevant External Links for ZDHHC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZDHHC2 Gene

mRNA expression in normal human tissues for ZDHHC2 Gene

Protein differential expression in normal tissues for ZDHHC2 Gene

This gene is overexpressed in Pancreatic juice (40.3) and Peripheral blood mononuclear cells (22.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZDHHC2 Gene

SOURCE GeneReport for Unigene cluster for ZDHHC2 Gene Hs.744097

mRNA Expression by UniProt/SwissProt for ZDHHC2 Gene

Tissue specificity: Ubiquitously expressed. Reduced expression in colorectal cancers with liver metastasis.
genes like me logo Genes that share expressions with ZDHHC2: view

Expression partners for ZDHHC2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ZDHHC2 Gene

Orthologs for ZDHHC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZDHHC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia LOC100687370 35
  • 93.83 (n)
  • 94.48 (a)
-- 36
  • 94 (a)
-- 36
  • 94 (a)
-- 36
  • 97 (a)
(Mus musculus)
Mammalia Zdhhc2 35
  • 91.35 (n)
  • 95.36 (a)
Zdhhc2 16
Zdhhc2 36
  • 95 (a)
(Pan troglodytes)
Mammalia ZDHHC2 35
  • 99.64 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Zdhhc2 35
  • 91.35 (n)
  • 95.36 (a)
(Bos Taurus)
Mammalia ZDHHC2 36
  • 87 (a)
(Monodelphis domestica)
Mammalia ZDHHC2 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia ZDHHC2 36
  • 86 (a)
(Gallus gallus)
Aves ZDHHC2 35
  • 81.19 (n)
  • 84.66 (a)
  • 81 (a)
(Anolis carolinensis)
Reptilia ZDHHC2 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc2 35
  • 78.51 (n)
  • 83.61 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19130 35
(Danio rerio)
Actinopterygii zdhhc2 35
  • 69.81 (n)
  • 75.83 (a)
zdhhc2 36
  • 75 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1407 37
  • 50 (a)
CG17287 37
  • 38 (a)
CG1407 36
  • 36 (a)
CG17287 36
  • 36 (a)
(Caenorhabditis elegans)
Secernentea ZK757.1 37
  • 38 (a)
ZK757.4 35
  • 50.45 (n)
  • 48.65 (a)
dhhc-4 36
  • 32 (a)
spe-10 36
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PFA3 36
  • 26 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G00840 35
  • 48.93 (n)
  • 36.6 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10082 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
Species with no ortholog for ZDHHC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC2 Gene

Gene Tree for ZDHHC2 (if available)
Gene Tree for ZDHHC2 (if available)

Paralogs for ZDHHC2 Gene

Paralogs for ZDHHC2 Gene

Selected SIMAP similar genes for ZDHHC2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZDHHC2: view

Variants for ZDHHC2 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs730243 -- 17,170,582(+) CCCTG(A/C)TAGAT intron-variant
rs756601 -- 17,170,660(+) TCAAA(C/T)AGCTA intron-variant
rs964949 -- 17,158,715(+) GGAAG(A/C)ATGCC intron-variant
rs966473 -- 17,172,612(+) AATAA(A/G)GAAAT intron-variant
rs1034557 -- 17,167,924(+) AGTAG(G/T)TTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC2 Gene

Variant ID Type Subtype PubMed ID
nsv831244 CNV Gain 17160897
nsv890555 CNV Loss 21882294
esv2736683 CNV Deletion 23290073
esv2736685 CNV Deletion 23290073
esv1030364 CNV Deletion 17803354
esv2736686 CNV Deletion 23290073

Relevant External Links for ZDHHC2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC2 Gene

Disorders for ZDHHC2 Gene


  • Note=Mutations in ZDHHC2 are found in hepatocellular carcinoma and colorectal cancer.

(1) University of Copenhagen DISEASES for ZDHHC2 Gene

Relevant External Links for ZDHHC2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ZDHHC2: view

No data available for MalaCards , OMIM , Novoseek inferred disease relationships and Genatlas for ZDHHC2 Gene

Publications for ZDHHC2 Gene

  1. Isolation of a novel gene on 8p21.3-22 whose expression is reduced significantly in human colorectal cancers with liver metastasis. (PMID: 10918388) Oyama T. … Nakamura Y. (Genes Chromosomes Cancer 2000) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein. (PMID: 21343290) Jia L. … Blumer K.J. (J. Biol. Chem. 2011) 3
  5. The palmitoyl transferase DHHC2 targets a dynamic membrane cycling pathway: regulation by a C-terminal domain. (PMID: 21471008) Greaves J. … Chamberlain L.H. (Mol. Biol. Cell 2011) 3

Products for ZDHHC2 Gene

Sources for ZDHHC2 Gene

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