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Aliases for ZDHHC2 Gene

Aliases for ZDHHC2 Gene

  • Zinc Finger DHHC-Type Containing 2 2 3
  • Reduced Expression Associated With Metastasis Protein 3 4
  • Zinc Finger DHHC Domain-Containing Protein 2 3 4
  • Reduced Expression In Cancer Protein 3 4
  • Zinc Finger, DHHC-Type Containing 2 3 5
  • Zinc Finger Protein 372 3 4
  • DHHC-2 3 4
  • ZNF372 3 4
  • Ream 3 4
  • Rec 3 4
  • Testis Tissue Sperm-Binding Protein Li 56e 3
  • Zinc Finger, DHHC Domain Containing 2 3
  • EC 2.3.1.225 4
  • EC 2.3.1 63
  • DHHC2 3

External Ids for ZDHHC2 Gene

Previous GeneCards Identifiers for ZDHHC2 Gene

  • GC08P016907
  • GC08P017093
  • GC08P017024
  • GC08P017023
  • GC08P017058
  • GC08P015559

Summaries for ZDHHC2 Gene

GeneCards Summary for ZDHHC2 Gene

ZDHHC2 (Zinc Finger DHHC-Type Containing 2) is a Protein Coding gene. Diseases associated with ZDHHC2 include Hepatocellular Carcinoma and Locked-In Syndrome. Among its related pathways are Surfactant metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include receptor activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC15.

UniProtKB/Swiss-Prot for ZDHHC2 Gene

  • Palmitoyltransferase specific for GAP43 and DLG4/PSD95.

Gene Wiki entry for ZDHHC2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC2 Gene

Genomics for ZDHHC2 Gene

Regulatory Elements for ZDHHC2 Gene

Enhancers for ZDHHC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZDHHC2 on UCSC Golden Path with GeneCards custom track

Promoters for ZDHHC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZDHHC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZDHHC2 Gene

Chromosome:
8
Start:
17,156,020 bp from pter
End:
17,224,799 bp from pter
Size:
68,780 bases
Orientation:
Plus strand

Genomic View for ZDHHC2 Gene

Genes around ZDHHC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC2 Gene

Proteins for ZDHHC2 Gene

  • Protein details for ZDHHC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIJ5-ZDHC2_HUMAN
    Recommended name:
    Palmitoyltransferase ZDHHC2
    Protein Accession:
    Q9UIJ5
    Secondary Accessions:
    • D3DSP5

    Protein attributes for ZDHHC2 Gene

    Size:
    367 amino acids
    Molecular mass:
    42022 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZDHHC2 Gene

Proteomics data for ZDHHC2 Gene at MOPED

Selected DME Specific Peptides for ZDHHC2 Gene

Post-translational modifications for ZDHHC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZDHHC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ZDHHC2 Gene

Gene Families for ZDHHC2 Gene

Protein Domains for ZDHHC2 Gene

Suggested Antigen Peptide Sequences for ZDHHC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UIJ5

UniProtKB/Swiss-Prot:

ZDHC2_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
  • Contains 1 DHHC-type zinc finger.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family.
Similarity:
  • Contains 1 DHHC-type zinc finger.
genes like me logo Genes that share domains with ZDHHC2: view

Function for ZDHHC2 Gene

Molecular function for ZDHHC2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
UniProtKB/Swiss-Prot Function:
Palmitoyltransferase specific for GAP43 and DLG4/PSD95.

Enzyme Numbers (IUBMB) for ZDHHC2 Gene

genes like me logo Genes that share phenotypes with ZDHHC2: view

Animal Models for ZDHHC2 Gene

MGI Knock Outs for ZDHHC2:

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZDHHC2 Gene

Localization for ZDHHC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZDHHC2 Gene COMPARTMENTS Subcellular localization image for ZDHHC2 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 5
endosome 2
extracellular 2

Gene Ontology (GO) - Cellular Components for ZDHHC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055038 recycling endosome membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC2: view

Pathways & Interactions for ZDHHC2 Gene

genes like me logo Genes that share pathways with ZDHHC2: view

Pathways by source for ZDHHC2 Gene

2 Reactome pathways for ZDHHC2 Gene

Gene Ontology (GO) - Biological Process for ZDHHC2 Gene

None

No data available for SIGNOR curated interactions for ZDHHC2 Gene

Drugs & Compounds for ZDHHC2 Gene

(1) Drugs for ZDHHC2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for ZDHHC2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
genes like me logo Genes that share compounds with ZDHHC2: view

Transcripts for ZDHHC2 Gene

Unigene Clusters for ZDHHC2 Gene

Zinc finger, DHHC-type containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: - -
SP2: - -
SP3:
SP4:

Relevant External Links for ZDHHC2 Gene

GeneLoc Exon Structure for
ZDHHC2
ECgene alternative splicing isoforms for
ZDHHC2

Expression for ZDHHC2 Gene

mRNA expression in normal human tissues for ZDHHC2 Gene

Protein differential expression in normal tissues from HIPED for ZDHHC2 Gene

This gene is overexpressed in Pancreatic juice (40.3) and Peripheral blood mononuclear cells (22.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZDHHC2 Gene



SOURCE GeneReport for Unigene cluster for ZDHHC2 Gene Hs.744097

mRNA Expression by UniProt/SwissProt for ZDHHC2 Gene

Q9UIJ5-ZDHC2_HUMAN
Tissue specificity: Ubiquitously expressed. Reduced expression in colorectal cancers with liver metastasis.
genes like me logo Genes that share expression patterns with ZDHHC2: view

Protein tissue co-expression partners for ZDHHC2 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for ZDHHC2 Gene

Orthologs for ZDHHC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZDHHC2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC100687370 35
  • 93.83 (n)
  • 94.48 (a)
-- 36
  • 94 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
-- 36
  • 97 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zdhhc2 35
  • 91.35 (n)
  • 95.36 (a)
Zdhhc2 16
Zdhhc2 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC2 35
  • 99.64 (n)
  • 100 (a)
ZDHHC2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zdhhc2 35
  • 91.35 (n)
  • 95.36 (a)
cow
(Bos Taurus)
Mammalia ZDHHC2 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZDHHC2 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC2 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZDHHC2 35
  • 81.19 (n)
  • 84.66 (a)
ZDHHC2 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZDHHC2 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc2 35
  • 78.51 (n)
  • 83.61 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19130 35
zebrafish
(Danio rerio)
Actinopterygii zdhhc2 35
  • 69.81 (n)
  • 75.83 (a)
zdhhc2 36
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1407 37
  • 50 (a)
CG17287 37
  • 38 (a)
CG1407 36
  • 36 (a)
ManyToMany
CG17287 36
  • 36 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ZK757.1 37
  • 38 (a)
ZK757.4 35
  • 50.45 (n)
  • 48.65 (a)
dhhc-4 36
  • 32 (a)
ManyToMany
spe-10 36
  • 28 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PFA3 36
  • 26 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G00840 35
  • 48.93 (n)
  • 36.6 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10082 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
Species with no ortholog for ZDHHC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC2 Gene

ENSEMBL:
Gene Tree for ZDHHC2 (if available)
TreeFam:
Gene Tree for ZDHHC2 (if available)

Paralogs for ZDHHC2 Gene

Paralogs for ZDHHC2 Gene

(9) SIMAP similar genes for ZDHHC2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZDHHC2: view

Variants for ZDHHC2 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_015229 A hepatocellular carcinoma sample
rs568589179 A colorectal cancer sample 17,217,176(+) GGTAT(C/G)AGCAA reference, missense
rs2023627 -- 17,189,217(+) ctcac(C/T)ttttt intron-variant
rs2023628 -- 17,189,625(+) TGACA(C/T)CATTG intron-variant
rs2106015 -- 17,213,290(+) attct(A/G)tcacc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC2 Gene

Variant ID Type Subtype PubMed ID
nsv831244 CNV Gain 17160897
nsv890555 CNV Loss 21882294
esv2736683 CNV Deletion 23290073
esv2736685 CNV Deletion 23290073
esv1030364 CNV Deletion 17803354
esv2736686 CNV Deletion 23290073

Variation tolerance for ZDHHC2 Gene

Residual Variation Intolerance Score: 59.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.38% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZDHHC2 Gene

Disorders for ZDHHC2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZDHHC2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
locked-in syndrome
  • locked in syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZDHHC2

Genetic Association Database (GAD)
ZDHHC2
Human Genome Epidemiology (HuGE) Navigator
ZDHHC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZDHHC2
genes like me logo Genes that share disorders with ZDHHC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZDHHC2 Gene

Publications for ZDHHC2 Gene

  1. Isolation of a novel gene on 8p21.3-22 whose expression is reduced significantly in human colorectal cancers with liver metastasis. (PMID: 10918388) Oyama T. … Nakamura Y. (Genes Chromosomes Cancer 2000) 2 3 4 67
  2. A critical role for ZDHHC2 in metastasis and recurrence in human hepatocellular carcinoma. (PMID: 24995331) Peng C. … Zheng S. (Biomed Res Int 2014) 3
  3. Reduced expression of ZDHHC2 is associated with lymph node metastasis and poor prognosis in gastric adenocarcinoma. (PMID: 23457560) Yan S.M. … Du Z.M. (PLoS ONE 2013) 3
  4. Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system. (PMID: 23034182) Ohno Y. … Kihara A. (Mol. Biol. Cell 2012) 3
  5. Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein. (PMID: 21343290) Jia L. … Blumer K.J. (J. Biol. Chem. 2011) 3

Products for ZDHHC2 Gene

Sources for ZDHHC2 Gene

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