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Aliases for ZDHHC19 Gene

Aliases for ZDHHC19 Gene

  • Zinc Finger DHHC-Type Containing 19 2 3 5
  • Zinc Finger DHHC Domain-Containing Protein 19 3 4
  • DHHC-19 3 4
  • Zinc Finger, DHHC Domain Containing 19 3
  • Probable Palmitoyltransferase ZDHHC19 3
  • EC 4
  • DHHC19 3

External Ids for ZDHHC19 Gene

Previous GeneCards Identifiers for ZDHHC19 Gene

  • GC03M196152
  • GC03M197331
  • GC03M197250
  • GC03M197412
  • GC03M195924
  • GC03M193224

Summaries for ZDHHC19 Gene

GeneCards Summary for ZDHHC19 Gene

ZDHHC19 (Zinc Finger DHHC-Type Containing 19) is a Protein Coding gene. GO annotations related to this gene include protein-cysteine S-palmitoyltransferase activity. An important paralog of this gene is ZDHHC8.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC19 Gene

Genomics for ZDHHC19 Gene

Regulatory Elements for ZDHHC19 Gene

Enhancers for ZDHHC19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G196213 1.2 Ensembl ENCODE 21.2 -4.2 -4150 3.6 FOXA2 ATF1 MLX CREB3L1 ARID4B DMAP1 ZNF48 YY1 SLC30A9 ZHX2 ZDHHC19 PCYT1A ENSG00000228028 TFRC SLC51A LOC105374304
GH03G196218 1.7 FANTOM5 Ensembl ENCODE dbSUPER 14.6 -8.8 -8764 2.8 MXI1 ARID4B SIN3A MAX BMI1 EBF1 ZIC2 EGR1 POLR2A FOS PCYT1A ZDHHC19 ENSG00000228028 TFRC SLC51A UBXN7 RNF168 NRROS CEP19 TNK2
GH03G196226 1.3 ENCODE dbSUPER 14.1 -16.5 -16476 2.1 HDGF ATF1 MLX ARID4B SIN3A DMAP1 ZNF48 SLC30A9 ZNF121 GLIS2 TM4SF19 PCYT1A ZDHHC19 SLC51A RNU7-18P RNU6-910P TFRC MUC4 PIR54915 LOC105374304
GH03G196206 1.4 Ensembl ENCODE dbSUPER 10.8 +3.7 3667 2.0 HDAC1 RB1 ARNT ZBTB40 YY1 ZNF121 EGR1 SMARCA5 SP3 SP1 ZDHHC19 SLC51A TCTEX1D2 ENSG00000222335
GH03G196337 1.9 FANTOM5 Ensembl ENCODE dbSUPER 6.7 -128.0 -127963 4.4 HDGF PKNOX1 CREB3L1 ARNT SIN3A YY1 ZNF766 FOS PAF1 JUNB TM4SF19 PCYT1A ZDHHC19 SLC51A ACAP2 UBXN7 RNF168 NRROS WDR53 GC03M196342
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZDHHC19 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZDHHC19 Gene

196,197,443 bp from pter
196,211,437 bp from pter
13,995 bases
Minus strand

Genomic View for ZDHHC19 Gene

Genes around ZDHHC19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC19 Gene

Proteins for ZDHHC19 Gene

  • Protein details for ZDHHC19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable palmitoyltransferase ZDHHC19
    Protein Accession:
    Secondary Accessions:
    • A8MSY6
    • B3KVI1

    Protein attributes for ZDHHC19 Gene

    309 amino acids
    Molecular mass:
    34352 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZDHHC19 Gene


neXtProt entry for ZDHHC19 Gene

Post-translational modifications for ZDHHC19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZDHHC19 Gene

No data available for DME Specific Peptides for ZDHHC19 Gene

Domains & Families for ZDHHC19 Gene

Gene Families for ZDHHC19 Gene

Protein Domains for ZDHHC19 Gene

Graphical View of Domain Structure for InterPro Entry



  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
genes like me logo Genes that share domains with ZDHHC19: view

Function for ZDHHC19 Gene

Molecular function for ZDHHC19 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Enzyme Numbers (IUBMB) for ZDHHC19 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC19: view

Phenotypes for ZDHHC19 Gene

genes like me logo Genes that share phenotypes with ZDHHC19: view

Animal Model Products

CRISPR Products

miRNA for ZDHHC19 Gene

miRTarBase miRNAs that target ZDHHC19

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC19 Gene

Localization for ZDHHC19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC19 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC19 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for ZDHHC19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 16647879
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC19: view

Pathways & Interactions for ZDHHC19 Gene

SuperPathways for ZDHHC19 Gene

No Data Available

Interacting Proteins for ZDHHC19 Gene

Gene Ontology (GO) - Biological Process for ZDHHC19 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZDHHC19 Gene

Drugs & Compounds for ZDHHC19 Gene

(1) Drugs for ZDHHC19 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for ZDHHC19 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZDHHC19: view

Transcripts for ZDHHC19 Gene

Unigene Clusters for ZDHHC19 Gene

Zinc finger, DHHC-type containing 19:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC19 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - -
SP2: - - -
SP3: - - -

Relevant External Links for ZDHHC19 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZDHHC19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZDHHC19 Gene

mRNA differential expression in normal tissues according to GTEx for ZDHHC19 Gene

This gene is overexpressed in Whole Blood (x31.6) and Testis (x12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZDHHC19 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZDHHC19 Gene:


SOURCE GeneReport for Unigene cluster for ZDHHC19 Gene:

genes like me logo Genes that share expression patterns with ZDHHC19: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC19 Gene

Orthologs for ZDHHC19 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC19 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZDHHC19 34 35
  • 98.71 (n)
(Canis familiaris)
Mammalia ZDHHC19 34 35
  • 86.88 (n)
(Bos Taurus)
Mammalia ZDHHC19 34 35
  • 86.29 (n)
(Mus musculus)
Mammalia Zdhhc19 34 16 35
  • 75.97 (n)
(Rattus norvegicus)
Mammalia Zdhhc19 34
  • 75.6 (n)
(Ornithorhynchus anatinus)
Mammalia ZDHHC19 35
  • 61 (a)
(Monodelphis domestica)
Mammalia ZDHHC19 35
  • 51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERF2 35
  • 15 (a)
Species where no ortholog for ZDHHC19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZDHHC19 Gene

Gene Tree for ZDHHC19 (if available)
Gene Tree for ZDHHC19 (if available)

Paralogs for ZDHHC19 Gene

Paralogs for ZDHHC19 Gene

(2) SIMAP similar genes for ZDHHC19 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZDHHC19: view

Variants for ZDHHC19 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC19 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000134160 -- 196,199,326(+) CGCCA(C/T)AGGGC intron-variant
rs1000186969 -- 196,199,485(+) CACCA(A/G)AGGAA intron-variant, nc-transcript-variant
rs1000362653 -- 196,202,663(+) CAGGC(C/T)GCTTC intron-variant
rs1000498594 -- 196,205,575(+) GGACT(A/G)TATCC intron-variant
rs1000834793 -- 196,207,099(+) GTGGG(C/T)GTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC19 Gene

Variant ID Type Subtype PubMed ID
esv2662732 CNV deletion 23128226
esv2759213 CNV gain+loss 17122850
esv32936 CNV gain 17666407
esv3569221 CNV loss 25503493
esv3599274 CNV loss 21293372
nsv1008512 CNV gain 25217958
nsv1009811 CNV gain 25217958
nsv1117363 CNV tandem duplication 24896259
nsv1139197 CNV deletion 24896259
nsv593071 CNV gain 21841781
nsv997797 CNV gain 25217958

Variation tolerance for ZDHHC19 Gene

Residual Variation Intolerance Score: 82.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.25; 62.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZDHHC19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC19 Gene

Disorders for ZDHHC19 Gene

Relevant External Links for ZDHHC19

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZDHHC19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC19 Gene

Publications for ZDHHC19 Gene

  1. Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population. (PMID: 21160409) Petrovski S. … Goldstein D.B. (AIDS 2011) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PMID: 20139978) Kamatani Y. … Kamatani N. (Nat. Genet. 2010) 3 64
  4. Palmitoylation of R-Ras by human DHHC19, a palmitoyl transferase with a CaaX box. (PMID: 20074548) Baumgart F. … RodrA-guez-Crespo I. (Biochim. Biophys. Acta 2010) 3 64
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4 64

Products for ZDHHC19 Gene

Sources for ZDHHC19 Gene

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