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Aliases for ZDHHC19 Gene

Aliases for ZDHHC19 Gene

  • Zinc Finger DHHC-Type Containing 19 2 3 5
  • Zinc Finger DHHC Domain-Containing Protein 19 3 4
  • DHHC-19 3 4
  • Zinc Finger, DHHC Domain Containing 19 3
  • Probable Palmitoyltransferase ZDHHC19 3
  • EC 2.3.1.225 4
  • DHHC19 3

External Ids for ZDHHC19 Gene

Previous GeneCards Identifiers for ZDHHC19 Gene

  • GC03M196152
  • GC03M197331
  • GC03M197250
  • GC03M197412
  • GC03M195924
  • GC03M193224

Summaries for ZDHHC19 Gene

GeneCards Summary for ZDHHC19 Gene

ZDHHC19 (Zinc Finger DHHC-Type Containing 19) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein-cysteine S-palmitoyltransferase activity. An important paralog of this gene is ZDHHC8.

Additional gene information for ZDHHC19 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC19 Gene

Genomics for ZDHHC19 Gene

GeneHancer (GH) Regulatory Elements for ZDHHC19 Gene

Promoters and enhancers for ZDHHC19 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I196210 Promoter/Enhancer 1.2 EPDnew ENCODE dbSUPER 557.6 +0.2 242 1 PKNOX1 IKZF1 ZNF341 EBF1 NR2F6 KDM1A SLC51A ZDHHC19 ENSG00000222335 GC03P196178
GH03I196212 Enhancer 0.2 ENCODE 550.8 -1.0 -988 0.2 SLC51A ZDHHC19 LOC105374304 GC03P196178
GH03I196213 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 21.2 -4.2 -4150 3.6 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 ETS1 YY1 SLC30A9 RXRA SLC51A ZDHHC19 PCYT1A ENSG00000228028 TFRC LOC105374304 GC03P196178
GH03I196218 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 14.6 -8.8 -8764 2.8 MXI1 FOXA2 RB1 ARID4B MAX EBF1 BMI1 ZIC2 POLR2A RCOR1 LOC105374304 PCYT1A ZDHHC19 ENSG00000228028 TFRC SLC51A UBXN7 RNF168 NRROS CEP19
GH03I196337 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.7 -128.0 -127963 4.4 HDGF PKNOX1 ARNT SIN3A YY1 POLR2B ZNF766 E2F8 FOS SMARCB1 TM4SF19 TM4SF19-TCTEX1D2 SDHAP1 LINC00969 UBXN7 SDHAP2 ENSG00000230732 ACAP2 ENSG00000260261 ENSG00000231443
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZDHHC19 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZDHHC19 gene promoter:

Genomic Locations for ZDHHC19 Gene

Genomic Locations for ZDHHC19 Gene
chr3:196,197,443-196,211,437
(GRCh38/hg38)
Size:
13,995 bases
Orientation:
Minus strand
chr3:195,924,320-195,938,308
(GRCh37/hg19)

Genomic View for ZDHHC19 Gene

Genes around ZDHHC19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC19 Gene

Proteins for ZDHHC19 Gene

  • Protein details for ZDHHC19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVZ1-ZDH19_HUMAN
    Recommended name:
    Probable palmitoyltransferase ZDHHC19
    Protein Accession:
    Q8WVZ1
    Secondary Accessions:
    • A8MSY6
    • B3KVI1

    Protein attributes for ZDHHC19 Gene

    Size:
    309 amino acids
    Molecular mass:
    34352 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZDHHC19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZDHHC19 Gene

Post-translational modifications for ZDHHC19 Gene

No Post-translational modifications

Other Protein References for ZDHHC19 Gene

No data available for DME Specific Peptides for ZDHHC19 Gene

Domains & Families for ZDHHC19 Gene

Gene Families for ZDHHC19 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for ZDHHC19 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WVZ1

UniProtKB/Swiss-Prot:

ZDH19_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family.
genes like me logo Genes that share domains with ZDHHC19: view

Function for ZDHHC19 Gene

Molecular function for ZDHHC19 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Enzyme Numbers (IUBMB) for ZDHHC19 Gene

Phenotypes From GWAS Catalog for ZDHHC19 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC19: view

Phenotypes for ZDHHC19 Gene

genes like me logo Genes that share phenotypes with ZDHHC19: view

Animal Model Products

CRISPR Products

miRNA for ZDHHC19 Gene

miRTarBase miRNAs that target ZDHHC19

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC19 Gene

Localization for ZDHHC19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC19 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC19 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for ZDHHC19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 16647879
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC19: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZDHHC19 Gene

Pathways & Interactions for ZDHHC19 Gene

SuperPathways for ZDHHC19 Gene

No Data Available

Interacting Proteins for ZDHHC19 Gene

Gene Ontology (GO) - Biological Process for ZDHHC19 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC19 Gene

Drugs & Compounds for ZDHHC19 Gene

(1) Drugs for ZDHHC19 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0

(1) Additional Compounds for ZDHHC19 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
genes like me logo Genes that share compounds with ZDHHC19: view

Transcripts for ZDHHC19 Gene

Unigene Clusters for ZDHHC19 Gene

Zinc finger, DHHC-type containing 19:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC19 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - -
SP2: - - -
SP3: - - -
SP4:

Relevant External Links for ZDHHC19 Gene

GeneLoc Exon Structure for
ZDHHC19
ECgene alternative splicing isoforms for
ZDHHC19

Expression for ZDHHC19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZDHHC19 Gene

mRNA differential expression in normal tissues according to GTEx for ZDHHC19 Gene

This gene is overexpressed in Whole Blood (x31.6) and Testis (x12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZDHHC19 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZDHHC19 Gene:

ZDHHC19

SOURCE GeneReport for Unigene cluster for ZDHHC19 Gene:

Hs.111591
genes like me logo Genes that share expression patterns with ZDHHC19: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC19 Gene

Orthologs for ZDHHC19 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC19 33 34
  • 98.71 (n)
dog
(Canis familiaris)
Mammalia ZDHHC19 33 34
  • 86.88 (n)
cow
(Bos Taurus)
Mammalia ZDHHC19 33 34
  • 86.29 (n)
mouse
(Mus musculus)
Mammalia Zdhhc19 33 16 34
  • 75.97 (n)
rat
(Rattus norvegicus)
Mammalia Zdhhc19 33
  • 75.6 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC19 34
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZDHHC19 34
  • 51 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERF2 34
  • 15 (a)
OneToMany
Species where no ortholog for ZDHHC19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZDHHC19 Gene

ENSEMBL:
Gene Tree for ZDHHC19 (if available)
TreeFam:
Gene Tree for ZDHHC19 (if available)

Paralogs for ZDHHC19 Gene

(2) SIMAP similar genes for ZDHHC19 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZDHHC19: view

Variants for ZDHHC19 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC19 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000134160 -- 196,199,326(-) C/T intron_variant
rs1000186969 -- 196,199,485(-) A/G intron_variant, non_coding_transcript_variant
rs1000362653 -- 196,202,663(-) C/T intron_variant
rs1000498594 -- 196,205,575(-) G/A intron_variant
rs1000834793 -- 196,207,099(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC19 Gene

Variant ID Type Subtype PubMed ID
esv2662732 CNV deletion 23128226
esv2759213 CNV gain+loss 17122850
esv32936 CNV gain 17666407
esv3569221 CNV loss 25503493
esv3599274 CNV loss 21293372
nsv1008512 CNV gain 25217958
nsv1009811 CNV gain 25217958
nsv1117363 CNV tandem duplication 24896259
nsv1139197 CNV deletion 24896259
nsv593071 CNV gain 21841781
nsv997797 CNV gain 25217958

Variation tolerance for ZDHHC19 Gene

Residual Variation Intolerance Score: 82.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.25; 62.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZDHHC19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZDHHC19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC19 Gene

Disorders for ZDHHC19 Gene

Additional Disease Information for ZDHHC19

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZDHHC19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC19 Gene

Publications for ZDHHC19 Gene

  1. Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population. (PMID: 21160409) Petrovski S … Center for HIV/AIDS Vaccine Immunology (AIDS (London, England) 2011) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Palmitoylation of R-Ras by human DHHC19, a palmitoyl transferase with a CaaX box. (PMID: 20074548) Baumgart F … Rodríguez-Crespo I (Biochimica et biophysica acta 2010) 3 58
  5. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PMID: 20139978) Kamatani Y … Kamatani N (Nature genetics 2010) 3 58

Products for ZDHHC19 Gene

Sources for ZDHHC19 Gene

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