ZDHHC19 Gene
protein-coding GIFtS: 43
GCID: GC03M195924
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|
zinc finger, DHHC-type containing 19
| |
Aliases
for ZDHHC19 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger, DHHC-Type Containing 191 2 | | DHHC192 | | Zinc Finger DHHC Domain-Containing Protein 192 3 | | Probable Palmitoyltransferase ZDHHC192 | | DHHC-192 3 | | Zinc Finger, DHHC Domain Containing 192 | | MGC333451 | | EC 2.3.1.-3 |
Export aliases for ZDHHC19 gene to outside databasesPrevious GC identifers: GC03M196152 GC03M197331 GC03M197250 GC03M197412 GC03M193224 |
Summaries
for ZDHHC19 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ZDHHC19 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_029928.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZDHHC19 gene promoter:
USF1 C/EBPbeta NRSF form 1 Lmo2 E47 CREB HOXA5 deltaCREB FOXO4 USF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZDHHC19
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZDHHC19 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q29 Ensembl cytogenetic band: 3q29 HGNC cytogenetic band: 3q29ZDHHC19 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M195924: view genomic region
(about GC identifiers)
Start:
|
195,924,320 bp from pter |
End:
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195,938,308 bp from pter |
Size:
|
13,989 bases |
Orientation:
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minus strand |
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Proteins
for ZDHHC19 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZDH19_HUMAN, Q8WVZ1 (See
protein sequence)Recommended Name: Probable palmitoyltransferase ZDHHC19 Size: 309 amino acids; 34352 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: A8MSY6Explore the universe of human proteins at neXtProt for ZDHHC19: NX_Q8WVZ1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WVZ1
ZDHHC19 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001034706.1
ENSEMBL proteins: ENSP00000296326 ENSP00000380678 ENSP00000393710
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
ZDHHC19 for ontologies About GeneDecksing
ZDHHC19 Antibody Products:
Assay Products for ZDHHC19: |
Protein
Domains /
Families
for ZDHHC19 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZDHHC19 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8WVZ1ProtoNet protein and cluster: Q8WVZ1 1 Blocks protein family: IPB001594 Zn-finger
UniProtKB/Swiss-Prot: ZDH19_HUMAN, Q8WVZ1Domain: The DHHC domain is required for palmitoyltransferase activity (By similarity)Similarity: Belongs to the DHHC palmitoyltransferase familySimilarity: Contains 1 DHHC-type zinc finger |
Function
for ZDHHC19 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZDH19_HUMAN, Q8WVZ1Catalytic activity: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoAEnzyme Number (IUBMB): EC 2.3.1.-1
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC19
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC19 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- | | GO:0016740 | transferase activity |
-- | -- | | GO:0016746 | transferase activity, transferring acyl groups |
IEA | -- |
ZDHHC19 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZDHHC19 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZDHHC19
|
Drugs & Compounds
for ZDHHC19 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZDHHC19
Search CenterWatch for drugs/clinical trials and news about ZDHHC19 / ZDH19
|
Transcripts
for ZDHHC19 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZDHHC19 gene (2 alternative transcripts): NM_144637.2 NM_001039617.1 Unigene Cluster for ZDHHC19: Zinc finger, DHHC-type containing 19 Hs.111591 [show with all ESTs]Unigene Representative Sequence: AK1229077 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000296326 ENST00000460442 ENST00000465519(uc010iaa.3) ENST00000397544(uc010iab.3)
ENST00000438232(uc003fwc.3 uc010hzz.3) ENST00000497422 ENST00000488508
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC19 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC19
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZDHHC19 (NM_001039617) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZDHHC19 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZDHHC19 |
Additional cDNA sequence: AK122907.1 7 DOTS entries: DT.120925642 DT.101976742 DT.101979142 DT.91988647 DT.91672040 DT.100747292 DT.407957 24/29 AceView cDNA sequences (see all 29): NM_144637 AA889122 BI826731 BC022078 CD171849 AA724452 BI561148 AA321133 BX112919 BI829234 AK122907 AW014300 CK300981 AI243741 BM709960 BI831582 AA620607 BU929650 BG721568 BC034801 AA860338 AA905063 BE503477 R76342
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC19 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 |
|---|
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| SP1: | | | | | | | | | | | | | - | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | | - | | | | | | - | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | | | - | | | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZDHHC19
|
Expression
for ZDHHC19 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZDHHC19 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTGAAGCTG
About this image
See ZDHHC19 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZDHHC19
SOURCE GeneReport for Unigene cluster: Hs.111591
SABiosciences Custom PCR Arrays for ZDHHC19
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZDHHC19
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZDHHC19 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZDHHC19 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZDHHC19 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC19 |
Orthologs
for ZDHHC19 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ZDHHC19 gene from 7/23 species (see all 23) About this table
ENSEMBL Gene Tree for ZDHHC19 (if available)
TreeFam Gene Tree for ZDHHC19 (if available) |
Paralogs
for ZDHHC19 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZDHHC19 gene
- ZDHHC142 ZDHHC52 ZDHHC122 ZDHHC82 ZDHHC182 ZDHHC92
2 SIMAP similar genes for ZDHHC19 using alignment to 2 protein entries: ZDH19_HUMAN (see all proteins):ZDHHC8 ZDHHC9
ZDHHC19 for paralogs About GeneDecksing
|
Genomic Variants
for ZDHHC19 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZDHHC19 (195924320 - 195938308 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for ZDHHC19
2 CNVs: 7400 3472
2 Inversions: 37243 0568 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZDHHC19 |
|
Disorders
/ Diseases
for ZDHHC19 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZDHHC19 for disorders About GeneDecksing
1  disease for ZDHHC19: About MalaCardsmalaria
Human Genome Epidemiology (HuGE) Navigator: ZDHHC19 (1 document)
Export disorders for ZDHHC19 gene to outside databases
|
Publications
for ZDHHC19 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZDHHC19 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZDHHC19) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Common human genetic variants and HIV-1 susceptibilit y: a genome-wide survey in a homogeneous African population. (PubMed id 21160409)1 Petrovski S....Goldstein D.B. (2011)
- Palmitoylation of R-Ras by human DHHC19, a palmitoyl transferase with a CaaX box. (PubMed id 20074548)1 Baumgart F....RodrA-guez-Crespo I. (2010)
- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZDHHC19 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZDHHC19 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZDHHC19 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZDHHC19 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZDHHC19 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZDHHC19 gene:
Search GeneIP for patents involving ZDHHC19
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZDHHC19 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | ZDHHC19 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC19 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZDHHC19 |
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