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Aliases for ZDHHC19 Gene

Aliases for ZDHHC19 Gene

  • Zinc Finger DHHC-Type Containing 19 2 3
  • Zinc Finger DHHC Domain-Containing Protein 19 3 4
  • Zinc Finger, DHHC-Type Containing 19 3 5
  • DHHC-19 3 4
  • Zinc Finger, DHHC Domain Containing 19 3
  • EC 2.3.1.225 4
  • DHHC19 3

External Ids for ZDHHC19 Gene

Previous GeneCards Identifiers for ZDHHC19 Gene

  • GC03M196152
  • GC03M197331
  • GC03M197250
  • GC03M197412
  • GC03M195924
  • GC03M193224

Summaries for ZDHHC19 Gene

GeneCards Summary for ZDHHC19 Gene

ZDHHC19 (Zinc Finger DHHC-Type Containing 19) is a Protein Coding gene. GO annotations related to this gene include protein-cysteine S-palmitoyltransferase activity. An important paralog of this gene is ZDHHC18.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC19 Gene

Genomics for ZDHHC19 Gene

Regulatory Elements for ZDHHC19 Gene

Genomic Location for ZDHHC19 Gene

Chromosome:
3
Start:
196,197,443 bp from pter
End:
196,211,437 bp from pter
Size:
13,995 bases
Orientation:
Minus strand

Genomic View for ZDHHC19 Gene

Genes around ZDHHC19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC19 Gene

Proteins for ZDHHC19 Gene

  • Protein details for ZDHHC19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVZ1-ZDH19_HUMAN
    Recommended name:
    Probable palmitoyltransferase ZDHHC19
    Protein Accession:
    Q8WVZ1
    Secondary Accessions:
    • A8MSY6
    • B3KVI1

    Protein attributes for ZDHHC19 Gene

    Size:
    309 amino acids
    Molecular mass:
    34352 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZDHHC19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZDHHC19 Gene

Proteomics data for ZDHHC19 Gene at MOPED

Post-translational modifications for ZDHHC19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZDHHC19 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZDHHC19 Gene

Domains & Families for ZDHHC19 Gene

Gene Families for ZDHHC19 Gene

Protein Domains for ZDHHC19 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WVZ1

UniProtKB/Swiss-Prot:

ZDH19_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
  • Contains 1 DHHC-type zinc finger.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family.
Similarity:
  • Contains 1 DHHC-type zinc finger.
genes like me logo Genes that share domains with ZDHHC19: view

Function for ZDHHC19 Gene

Molecular function for ZDHHC19 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Enzyme Numbers (IUBMB) for ZDHHC19 Gene

Phenotypes for ZDHHC19 Gene

GenomeRNAi human phenotypes for ZDHHC19:
genes like me logo Genes that share phenotypes with ZDHHC19: view

Animal Model Products

CRISPR Products

miRNA for ZDHHC19 Gene

miRTarBase miRNAs that target ZDHHC19

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC19 Gene

Localization for ZDHHC19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC19 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZDHHC19 Gene COMPARTMENTS Subcellular localization image for ZDHHC19 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for ZDHHC19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC19: view

Pathways & Interactions for ZDHHC19 Gene

SuperPathways for ZDHHC19 Gene

No Data Available

Interacting Proteins for ZDHHC19 Gene

Gene Ontology (GO) - Biological Process for ZDHHC19 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC19 Gene

Drugs & Compounds for ZDHHC19 Gene

(1) Drugs for ZDHHC19 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for ZDHHC19 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
genes like me logo Genes that share compounds with ZDHHC19: view

Transcripts for ZDHHC19 Gene

Unigene Clusters for ZDHHC19 Gene

Zinc finger, DHHC-type containing 19:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC19 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - -
SP2: - - -
SP3: - - -
SP4:

Relevant External Links for ZDHHC19 Gene

GeneLoc Exon Structure for
ZDHHC19
ECgene alternative splicing isoforms for
ZDHHC19

Expression for ZDHHC19 Gene

mRNA expression in normal human tissues for ZDHHC19 Gene

mRNA differential expression in normal tissues according to GTEx for ZDHHC19 Gene

This gene is overexpressed in Whole Blood (x31.6) and Testis (x12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZDHHC19 Gene



SOURCE GeneReport for Unigene cluster for ZDHHC19 Gene Hs.111591

genes like me logo Genes that share expression patterns with ZDHHC19: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZDHHC19 Gene

Orthologs for ZDHHC19 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC19 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZDHHC19 35
  • 86.29 (n)
  • 84.62 (a)
ZDHHC19 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZDHHC19 35
  • 86.88 (n)
  • 84.62 (a)
ZDHHC19 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zdhhc19 35
  • 75.97 (n)
  • 69.81 (a)
Zdhhc19 16
Zdhhc19 36
  • 62 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC19 35
  • 98.71 (n)
  • 98.06 (a)
ZDHHC19 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zdhhc19 35
  • 75.6 (n)
  • 69.61 (a)
oppossum
(Monodelphis domestica)
Mammalia ZDHHC19 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC19 36
  • 61 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERF2 36
  • 15 (a)
OneToMany
Species with no ortholog for ZDHHC19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZDHHC19 Gene

ENSEMBL:
Gene Tree for ZDHHC19 (if available)
TreeFam:
Gene Tree for ZDHHC19 (if available)

Paralogs for ZDHHC19 Gene

Paralogs for ZDHHC19 Gene

(2) SIMAP similar genes for ZDHHC19 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZDHHC19: view

Variants for ZDHHC19 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC19 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs13315830 - 196,210,687(+) GGGAG(C/G)CTGTG intron-variant, nc-transcript-variant, reference, missense
rs939891 -- 196,199,219(+) AAGTC(C/G)TCCCC intron-variant
rs939892 -- 196,199,363(+) GCCTT(C/T)GCTGT intron-variant, nc-transcript-variant
rs1105977 -- 196,202,381(+) CGCCT(G/T)TTCAG intron-variant
rs1105978 -- 196,202,509(+) GGACG(C/T)ACTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC19 Gene

Variant ID Type Subtype PubMed ID
dgv1549e1 CNV Complex 17122850
nsv878171 CNV Gain 21882294
nsv878174 CNV Loss 21882294
nsv878175 CNV Loss 21882294
esv32936 CNV Gain 17666407
nsv878176 CNV Gain 21882294
esv2662732 CNV Deletion 23128226
nsv878177 CNV Loss 21882294
dgv5372n71 CNV Gain 21882294
esv2726575 CNV Deletion 23290073

Variation tolerance for ZDHHC19 Gene

Residual Variation Intolerance Score: 82.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.25; 62.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZDHHC19 Gene

HapMap Linkage Disequilibrium report
ZDHHC19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC19 Gene

Disorders for ZDHHC19 Gene

Relevant External Links for ZDHHC19

Genetic Association Database (GAD)
ZDHHC19
Human Genome Epidemiology (HuGE) Navigator
ZDHHC19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZDHHC19

No disorders were found for ZDHHC19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC19 Gene

Publications for ZDHHC19 Gene

  1. Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population. (PMID: 21160409) Petrovski S. … Goldstein D.B. (AIDS 2011) 3 48 67
  2. Palmitoylation of R-Ras by human DHHC19, a palmitoyl transferase with a CaaX box. (PMID: 20074548) Baumgart F. … RodrA-guez-Crespo I. (Biochim. Biophys. Acta 2010) 3
  3. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PMID: 20139978) Kamatani Y. … Kamatani N. (Nat. Genet. 2010) 3
  4. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. (PMID: 16647879) Ohno Y. … Igarashi Y. (Biochim. Biophys. Acta 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ZDHHC19 Gene

Sources for ZDHHC19 Gene

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