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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZDHHC19 Gene

protein-coding   GIFtS: 43
GCID: GC03M195924

Zinc Finger, DHHC-Type Containing 19

  Search for ZDHHC19
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger, DHHC-Type Containing 191 2     Probable Palmitoyltransferase ZDHHC192
Zinc Finger DHHC Domain-Containing Protein 192 3     Zinc Finger, DHHC Domain Containing 192
DHHC-192 3     EC 2.3.1.-3
DHHC192     

External Ids:    HGNC: 207131   Entrez Gene: 1315402   Ensembl: ENSG000001639587   UniProtKB: Q8WVZ13   

Export aliases for ZDHHC19 gene to outside databases

Previous GC identifers: GC03M196152 GC03M197331 GC03M197250 GC03M197412 GC03M193224


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZDHHC19 Gene: 
ZDHHC19 (zinc finger, DHHC-type containing 19) is a protein-coding gene. GO annotations related to this gene include transferase activity, transferring acyl groups and zinc ion binding. An important paralog of this gene is ZDHHC14.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_029928.13  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZDHHC19 gene promoter:
         USF1   C/EBPbeta   NRSF form 1   Lmo2   E47   CREB   HOXA5   deltaCREB   FOXO4   USF-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZDHHC19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZDHHC19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q29   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q29

ZDHHC19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZDHHC19 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M195924:  view genomic region     (about GC identifiers)

Start:
195,924,320 bp from pter      End:
195,938,308 bp from pter
Size:
13,989 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZDH19_HUMAN, Q8WVZ1 (See protein sequence)
Recommended Name: Probable palmitoyltransferase ZDHHC19  
Size: 309 amino acids; 34352 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: A8MSY6

Explore the universe of human proteins at neXtProt for ZDHHC19: NX_Q8WVZ1

Explore proteomics data for ZDHHC19 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WVZ1

  • ZDHHC19 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZDHHC19 Protein Expression
    REFSEQ proteins: NP_001034706.1  
    ENSEMBL proteins: 
     ENSP00000296326   ENSP00000380678   ENSP00000393710  

    Human Recombinant Protein Products for ZDHHC19: 
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    Cloud-Clone Corp. Proteins for ZDHHC19 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    ZDHHC19 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZDHHC: Zinc fingers, DHHC-type

    1 InterPro protein domain:
     IPR001594 Znf_DHHC_palmitoyltrfase

    Graphical View of Domain Structure for InterPro Entry Q8WVZ1

    ProtoNet protein and cluster: Q8WVZ1

    1 Blocks protein domain: IPB001594 Zn-finger

    UniProtKB/Swiss-Prot: ZDH19_HUMAN, Q8WVZ1
    Domain: The DHHC domain is required for palmitoyltransferase activity (By similarity)
    Similarity: Belongs to the DHHC palmitoyltransferase family
    Similarity: Contains 1 DHHC-type zinc finger


    ZDHHC19 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZDH19_HUMAN, Q8WVZ1
    Catalytic activity: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA

         Enzyme Number (IUBMB): EC 2.3.1.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
    GO:0016740transferase activity ----
    GO:0016746transferase activity, transferring acyl groups IEA--
         
    ZDHHC19 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZDHHC19

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZDHHC19 (ZDH19)

    Search CenterWatch for drugs/clinical trials and news about ZDHHC19 / ZDH19

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZDHHC19 gene (2 alternative transcripts): 
    NM_144637.2  NM_001039617.1  

    Unigene Cluster for ZDHHC19:

    Zinc finger, DHHC-type containing 19
    Hs.111591  [show with all ESTs]
    Unigene Representative Sequence: AK122907
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296326 ENST00000460442 ENST00000465519(uc010iaa.3) ENST00000397544(uc010iab.3)
    ENST00000438232(uc003fwc.3 uc010hzz.3) ENST00000497422 ENST00000488508

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    hsa-miR-3690 hsa-miR-4254
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Additional mRNA sequence: AK122907.1 

    7 DOTS entries:

    DT.120925642  DT.101976742  DT.101979142  DT.91988647  DT.91672040  DT.100747292  DT.407957 

    24/29 AceView cDNA sequences (see all 29):

    AA724452 AA889122 NM_144637 BI826731 CD171849 BC022078 BG721568 AK122907 
    AA620607 BI829234 BM709960 BC034801 BI831582 BI561148 AA321133 CK300981 
    AW014300 BU929650 AI243741 BX112919 AA905063 BE503477 AA860338 BE671930 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC19    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
    SP1:                                      -                                   -               
    SP2:                                      -                       -                 -         
    SP3:                    -                                         -           -               
    SP4:                                                                                          


    ECgene alternative splicing isoforms for ZDHHC19

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZDHHC19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGAAGCTG
    ZDHHC19 Expression
    About this image


    See ZDHHC19 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZDHHC19

    SOURCE GeneReport for Unigene cluster: Hs.111591
        SABiosciences Custom PCR Arrays for ZDHHC19
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC19

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ZDHHC19 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zdhhc191 , 5 zinc finger, DHHC domain containing 191, 5 76.19(n)1
    69.81(a)1
      16 (22.76 cM)5
    2453081  NM_199309.21  NP_955013.11 
     324962655 
    lizard
    (Anolis carolinensis)
    Reptilia ZDHHC86
    Uncharacterized protein
    41(a)
    1 ↔ 1
    GL343887.1(115529-119304)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ERF26
    Subunit of a palmitoyltransferase, composed of Erf...
    19(a)
    1 → many
    XII(627118-628197)


    ENSEMBL Gene Tree for ZDHHC19 (if available)
    TreeFam Gene Tree for ZDHHC19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZDHHC19 gene
    ZDHHC142  ZDHHC52  ZDHHC11B2  ZDHHC42  ZDHHC82  ZDHHC92  ZDHHC12  ZDHHC112  
    ZDHHC182  
    2 SIMAP similar genes for ZDHHC19 using alignment to 2 protein entries:     ZDH19_HUMAN (see all proteins):
    ZDHHC8    ZDHHC9

    ZDHHC19 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/551 SNPs in ZDHHC19 are shown (see all 551)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1122143561,2
    C--195923985(+) GCATGC/TACCAC 1 -- int10--------
    rs624105391,2
    C,F--195924036(+) TTTCAC/TTATGT 1 -- int13Minor allele frequency- T:0.50NA 6
    rs1837674311,2
    --195924063(+) GAACTC/TCTGAC 1 -- int10--------
    rs1509663051,2
    --195924110(+) ACAGGC/TGTGAG 1 -- int10--------
    rs1891110801,2
    --195924135(+) CTATTG/TTTGCC 1 -- int10--------
    rs1153704651,2
    F--195924143(+) GCCCAA/GTTTTA 1 -- int11Minor allele frequency- G:0.03NA 120
    rs1143252301,2
    F--195924151(+) TTAAGG/AAGGAG 1 -- int11Minor allele frequency- A:0.04NA 120
    rs1395107071,2
    C--195924171(+) AGGTGC/TCTTGT 1 -- int10--------
    rs1815158941,2
    --195924194(+) AGCCAC/GGTGGT 1 -- int10--------
    rs76266801,2
    C,F,A,H--195924203(+) GTGTCA/GGGTCC 1 -- int120Minor allele frequency- G:0.48EA NS NA CSA WA 2122

    HapMap Linkage Disequilibrium report for ZDHHC19 (195924320 - 195938308 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for ZDHHC19:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2726575CNV Deletion23290073
    esv2662732CNV Deletion23128226
    nsv878177CNV Loss21882294
    nsv878174CNV Loss21882294
    nsv878175CNV Loss21882294
    nsv878176CNV Gain21882294
    esv32936CNV Gain17666407
    dgv5372n71CNV Gain21882294
    nsv878171CNV Gain21882294
    dgv1549e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZDHHC19 for disorders           About MalaCards

    ZDHHC19 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZDHHC19
    Human Genome Epidemiology (HuGE) Navigator: ZDHHC19 (1 document)

    Export disorders for ZDHHC19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZDHHC19 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZDHHC19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Common human genetic variants and HIV-1 susceptibilit y: a genome-wide survey in a homogeneous African population. (PubMed id 21160409)1, 4 Petrovski S....Goldstein D.B. (2011)
    2. Palmitoylation of R-Ras by human DHHC19, a palmitoyl transferase with a CaaX box. (PubMed id 20074548)1 Baumgart F....RodrA-guez-Crespo I. (2010)
    3. Genome-wide association study of hematological and bi ochemical traits in a Japanese population. (PubMed id 20139978)1 Kamatani Y....Kamatani N. (2010)
    4. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 131540 HGNC: 20713 AceView: ZDHHC19 Ensembl:ENSG00000163958 euGenes: HUgn131540
    ECgene: ZDHHC19 H-InvDB: ZDHHC19

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZDHHC19 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZDHHC19 gene:
    Search GeneIP for patents involving ZDHHC19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
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    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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