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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZDHHC18 Gene

protein-coding   GIFtS: 44
GCID: GC01P027153

Zinc Finger, DHHC-Type Containing 18

  Search for ZDHHC18
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger, DHHC-Type Containing 181 2     Palmitoyltransferase ZDHHC182
Zinc Finger DHHC Domain-Containing Protein 182 3     Zinc Finger, DHHC Domain Containing 182
DHHC-182 3     EC 2.3.1.-3
DHHC182     EC 2.3.18

External Ids:    HGNC: 207121   Entrez Gene: 842432   Ensembl: ENSG000002041607   UniProtKB: Q9NUE03   

Export aliases for ZDHHC18 gene to outside databases

Previous GC identifers: GC01P026185 GC01P026386 GC01P026757 GC01P026837 GC01P027025 GC01P025406


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZDHHC18 Gene: 
ZDHHC18 (zinc finger, DHHC-type containing 18) is a protein-coding gene. GO annotations related to this gene include palmitoyltransferase activity and zinc ion binding. An important paralog of this gene is ZDHHC1.

UniProtKB/Swiss-Prot: ZDH18_HUMAN, Q9NUE0
Function: Has palmitoyltransferase activity towards HRAS and LCK (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004610.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZDHHC18 gene promoter:
         E2F-3a   SRF   SRF (504 AA)   E2F-2   AP-4   LCR-F1   YY1   Pax-3   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZDHHC18 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZDHHC18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZDHHC18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36.11

ZDHHC18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZDHHC18 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P027153:  view genomic region     (about GC identifiers)

Start:
27,153,201 bp from pter      End:
27,184,093 bp from pter
Size:
30,893 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZDH18_HUMAN, Q9NUE0 (See protein sequence)
Recommended Name: Palmitoyltransferase ZDHHC18  
Size: 388 amino acids; 42031 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=CAI21624.1; Type=Erroneous initiation;
Secondary accessions: A6NHY9 Q5JYH0 Q9H020

Explore the universe of human proteins at neXtProt for ZDHHC18: NX_Q9NUE0

Explore proteomics data for ZDHHC18 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NUE0

  • 4/8 DME Specific Peptides for ZDHHC18 (Q9NUE0) (see all 8)
     FDCPYLA  YRPPPRT  ILFFFVM  VLCGPLPPS 

    ZDHHC18 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZDHHC18 Protein Expression
    REFSEQ proteins: NP_115659.1  
    ENSEMBL proteins: 
     ENSP00000363257   ENSP00000363256   ENSP00000435510   ENSP00000436203  

    Human Recombinant Protein Products for ZDHHC18: 
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    Cloud-Clone Corp. Proteins for ZDHHC18 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    ZDHHC18 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZDHHC: Zinc fingers, DHHC-type

    1 InterPro protein domain:
     IPR001594 Znf_DHHC_palmitoyltrfase

    Graphical View of Domain Structure for InterPro Entry Q9NUE0

    ProtoNet protein and cluster: Q9NUE0

    1 Blocks protein domain: IPB001594 Zn-finger

    UniProtKB/Swiss-Prot: ZDH18_HUMAN, Q9NUE0
    Domain: The DHHC domain is required for palmitoyltransferase activity (By similarity)
    Similarity: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily
    Similarity: Contains 1 DHHC-type zinc finger


    ZDHHC18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZDH18_HUMAN, Q9NUE0
    Function: Has palmitoyltransferase activity towards HRAS and LCK (By similarity)
    Catalytic activity: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA

         Enzyme Numbers (IUBMB): EC 2.3.12 EC 2.3.1.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
    GO:0016409palmitoyltransferase activity IEA--
         
    ZDHHC18 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZDHHC18:
     Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZDHHC18 
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    SwitchGear 3'UTR luciferase reporter plasmidZDHHC18 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC18


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZDHHC18

    2 Interacting proteins for ZDHHC18 (Q9NUE03) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HRASP011123I2D: score=1 
    LCKP062393I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0034613cellular protein localization IEA--

    ZDHHC18 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZDHHC18 (ZDH18)

    Search CenterWatch for drugs/clinical trials and news about ZDHHC18 / ZDH18

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZDHHC18 gene: 
    NM_032283.2  

    Unigene Cluster for ZDHHC18:

    Zinc finger, DHHC-type containing 18
    Hs.523710  [show with all ESTs]
    Unigene Representative Sequence: NM_032283
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374142(uc001bnb.3) ENST00000374141(uc010ofh.1) ENST00000534643
    ENST00000488397 ENST00000478902
    miRNA
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    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate ZDHHC18 (see all 44):
    hsa-miR-3130-5p hsa-miR-193a-3p hsa-miR-3194-5p hsa-miR-429 hsa-miR-485-3p hsa-miR-9 hsa-miR-556-3p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidZDHHC18 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK056427.1 AK091260.1 AK298683.1 AL512765.1 BC066776.1 

    10 DOTS entries:

    DT.451819  DT.101969354  DT.422346  DT.99993284  DT.121398875  DT.100784619  DT.99985018  DT.100784620 
    DT.121398834  DT.99968931 

    24/197 AceView cDNA sequences (see all 197):

    CD671312 NM_032283 BE676622 C00471 AI739298 BE550169 CA431020 BM790953 
    BE676284 AI703083 CR600621 AI151381 BE218594 CB529912 Z45373 BM932323 
    BC066776 BM929476 BF512598 AI745525 BI868296 CB852692 AL512765 CR614359 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZDHHC18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGCCCTGT
    ZDHHC18 Expression
    About this image


    See ZDHHC18 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZDHHC18

    SOURCE GeneReport for Unigene cluster: Hs.523710
        SABiosciences Custom PCR Arrays for ZDHHC18
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ZDHHC18 gene from 9/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zdhhc181 , 5 zinc finger, DHHC domain containing 181, 5 90.35(n)1
    95.26(a)1
      4 (66.25 cM)5
    5036101  NM_001017968.21  NP_001017968.21 
     1336052995 
    chicken
    (Gallus gallus)
    Aves ZDHHC186
    zinc finger, DHHC-type containing 18
    72(a)
    1 ↔ 1
    23(1777773-1788935)
    lizard
    (Anolis carolinensis)
    Reptilia ZDHHC186
    zinc finger, DHHC-type containing 18
    66(a)
    1 ↔ 1
    GL343488.1(122613-140421)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.91652 Danio rerio mRNA similar to zinc finger, DHHC domain more 75.61(n)    BC045475.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta app1 approximated 60.98(n)
    62.88(a)
      39399  NM_140304.5  NP_648561.2 
    worm
    (Caenorhabditis elegans)
    Secernentea dhhc-26
    Protein DHHC-2
    36(a)
    1 → many
    I(11836460-11849247)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ERF26
    Subunit of a palmitoyltransferase, composed of Erf...
    20(a)
    1 → many
    XII(627118-628197)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G269351 putative S-acyltransferase 47.78(n)
    40.33(a)
      822311  NM_180307.3  NP_850638.1 
    rice
    (Oryza sativa)
    Liliopsida Os.172952 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.05(n)    AK121806.1 


    ENSEMBL Gene Tree for ZDHHC18 (if available)
    TreeFam Gene Tree for ZDHHC18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZDHHC18 gene
    ZDHHC12  ZDHHC142  ZDHHC112  ZDHHC52  ZDHHC11B2  ZDHHC42  ZDHHC82  ZDHHC192  
    ZDHHC92  
    9 SIMAP similar genes for ZDHHC18 using alignment to 4 protein entries:     ZDH18_HUMAN (see all proteins):
    ZDHHC14    ZDHHC5    ZDHHC2    ZDHHC9    ZDHHC8    ZDHHC11B
    ZDHHC1    ZDHHC3    ZDHHC7

    ZDHHC18 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/624 SNPs in ZDHHC18 are shown (see all 624)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1874252371,2
    --27151230(+) GACAGA/TTGCAA 1 -- us2k10--------
    rs786291951,2
    C,F--27151346(+) AGGACC/TCAGTT 1 -- us2k12Minor allele frequency- T:0.02NA EA 240
    rs2010866991,2
    --27151480(+) TTGAG-/CAGCCT 1 -- us2k10--------
    rs1917922871,2
    --27151555(+) CTGTTC/GTCGGC 1 -- us2k10--------
    rs1409702861,2
    C--27151720(+) ATTTAC/TGCCTT 1 -- us2k10--------
    rs794882471,2
    C--27151733(+) GTGATT/CCCCTT 1 -- us2k12Minor allele frequency- C:0.04NA 122
    rs1829300331,2
    --27151990(+) AGACAA/CCCAGC 1 -- us2k10--------
    rs617865161,2
    C--27152043(+) AATCCC/TAGGCC 1 -- us2k15Minor allele frequency- T:0.12WA NA EA 362
    rs1502144891,2
    --27152217(+) TGGAAA/CCTGTT 1 -- us2k10--------
    rs1866521001,2
    --27152255(+) GAGACA/GGAGTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZDHHC18 (27153201 - 27184093 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZDHHC18:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv870975CNV Loss21882294
    nsv834524CNV Gain+Loss17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZDHHC18 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZDHHC18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84243 HGNC: 20712 AceView: ZDHHC18 Ensembl:ENSG00000204160 euGenes: HUgn84243
    ECgene: ZDHHC18 H-InvDB: ZDHHC18

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZDHHC18 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZDHHC18 gene:
    Search GeneIP for patents involving ZDHHC18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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