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Aliases for ZDHHC18 Gene

Aliases for ZDHHC18 Gene

  • Zinc Finger DHHC-Type Containing 18 2 3
  • Zinc Finger DHHC Domain-Containing Protein 18 3 4
  • Zinc Finger, DHHC-Type Containing 18 3 5
  • DHHC-18 3 4
  • Zinc Finger, DHHC Domain Containing 18 3
  • EC 4
  • EC 2.3.1 63
  • DHHC18 3

External Ids for ZDHHC18 Gene

Previous GeneCards Identifiers for ZDHHC18 Gene

  • GC01P026185
  • GC01P026386
  • GC01P026757
  • GC01P027025
  • GC01P027153
  • GC01P025406

Summaries for ZDHHC18 Gene

GeneCards Summary for ZDHHC18 Gene

ZDHHC18 (Zinc Finger DHHC-Type Containing 18) is a Protein Coding gene. GO annotations related to this gene include protein-cysteine S-palmitoyltransferase activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC23.

UniProtKB/Swiss-Prot for ZDHHC18 Gene

  • Has palmitoyltransferase activity towards HRAS and LCK.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC18 Gene

Genomics for ZDHHC18 Gene

Regulatory Elements for ZDHHC18 Gene

Enhancers for ZDHHC18 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZDHHC18 on UCSC Golden Path with GeneCards custom track

Promoters for ZDHHC18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZDHHC18 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZDHHC18 Gene

26,826,710 bp from pter
26,857,602 bp from pter
30,893 bases
Plus strand

Genomic View for ZDHHC18 Gene

Genes around ZDHHC18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC18 Gene

Proteins for ZDHHC18 Gene

  • Protein details for ZDHHC18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Palmitoyltransferase ZDHHC18
    Protein Accession:
    Secondary Accessions:
    • A6NHY9
    • B4DQ84
    • Q5JYH0
    • Q9H020

    Protein attributes for ZDHHC18 Gene

    388 amino acids
    Molecular mass:
    42031 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI21624.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZDHHC18 Gene


neXtProt entry for ZDHHC18 Gene

Proteomics data for ZDHHC18 Gene at MOPED

Selected DME Specific Peptides for ZDHHC18 Gene

Post-translational modifications for ZDHHC18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZDHHC18 Gene

Domains & Families for ZDHHC18 Gene

Gene Families for ZDHHC18 Gene

Protein Domains for ZDHHC18 Gene

Suggested Antigen Peptide Sequences for ZDHHC18 Gene

Graphical View of Domain Structure for InterPro Entry



  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
  • Contains 1 DHHC-type zinc finger.
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
  • Contains 1 DHHC-type zinc finger.
genes like me logo Genes that share domains with ZDHHC18: view

Function for ZDHHC18 Gene

Molecular function for ZDHHC18 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
UniProtKB/Swiss-Prot Function:
Has palmitoyltransferase activity towards HRAS and LCK.

Enzyme Numbers (IUBMB) for ZDHHC18 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016409 palmitoyltransferase activity IDA 23034182
genes like me logo Genes that share ontologies with ZDHHC18: view
genes like me logo Genes that share phenotypes with ZDHHC18: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ZDHHC18

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC18 Gene

Localization for ZDHHC18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC18 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ZDHHC18 Gene COMPARTMENTS Subcellular localization image for ZDHHC18 gene
Compartment Confidence
golgi apparatus 5
cytoskeleton 3
plasma membrane 3
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ZDHHC18 Gene

Pathways & Interactions for ZDHHC18 Gene

SuperPathways for ZDHHC18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC18 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZDHHC18 Gene

Drugs & Compounds for ZDHHC18 Gene

(1) Drugs for ZDHHC18 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for ZDHHC18 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZDHHC18: view

Transcripts for ZDHHC18 Gene

Unigene Clusters for ZDHHC18 Gene

Zinc finger, DHHC-type containing 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC18 Gene

No ASD Table

Relevant External Links for ZDHHC18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZDHHC18 Gene

mRNA expression in normal human tissues for ZDHHC18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZDHHC18 Gene

This gene is overexpressed in Whole Blood (x18.9).

Protein differential expression in normal tissues from HIPED for ZDHHC18 Gene

This gene is overexpressed in Placenta (55.1) and Fetal Liver (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZDHHC18 Gene

SOURCE GeneReport for Unigene cluster for ZDHHC18 Gene Hs.523710

genes like me logo Genes that share expression patterns with ZDHHC18: view

Protein tissue co-expression partners for ZDHHC18 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ZDHHC18 Gene

Orthologs for ZDHHC18 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZDHHC18 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZDHHC18 35
  • 89.77 (n)
  • 90.42 (a)
ZDHHC18 36
  • 87 (a)
(Mus musculus)
Mammalia Zdhhc18 35
  • 90.09 (n)
  • 94.74 (a)
Zdhhc18 16
Zdhhc18 36
  • 95 (a)
(Pan troglodytes)
Mammalia ZDHHC18 35
  • 99.34 (n)
  • 99.61 (a)
(Rattus norvegicus)
Mammalia Zdhhc18 35
  • 89.15 (n)
  • 94.01 (a)
(Canis familiaris)
Mammalia ZDHHC18 36
  • 95 (a)
(Monodelphis domestica)
Mammalia ZDHHC18 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia ZDHHC18 36
  • 63 (a)
(Gallus gallus)
Aves ZDHHC18 36
  • 76 (a)
(Anolis carolinensis)
Reptilia ZDHHC18 36
  • 71 (a)
(Danio rerio)
Actinopterygii Dr.9165 35
zdhhc18a 35
  • 66.57 (n)
  • 71.43 (a)
zdhhc18b 36
  • 71 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005111 35
  • 60.27 (n)
  • 62.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta app 36
  • 26 (a)
(Caenorhabditis elegans)
Secernentea dhhc-2 36
  • 36 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G50020 35
  • 47.12 (n)
  • 41.36 (a)
(Oryza sativa)
Liliopsida Os.17295 35
Os01g0868200 35
  • 47.77 (n)
  • 40.55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3762 36
  • 52 (a)
Species with no ortholog for ZDHHC18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZDHHC18 Gene

Gene Tree for ZDHHC18 (if available)
Gene Tree for ZDHHC18 (if available)

Paralogs for ZDHHC18 Gene

Paralogs for ZDHHC18 Gene

(9) SIMAP similar genes for ZDHHC18 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZDHHC18: view

Variants for ZDHHC18 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC18 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs737524 -- 26,854,338(+) CCTTT(A/C)TTCTG utr-variant-3-prime
rs760092 -- 26,854,898(+) TCCCA(G/T)ATCCC utr-variant-3-prime
rs760093 -- 26,854,936(+) TGAGT(A/G)TCAGA utr-variant-3-prime
rs1055223 -- 26,832,510(-) ACGAA(A/G)AAGAA reference, synonymous-codon
rs1055225 -- 26,832,507(-) AAGAA(A/G)AAGAG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC18 Gene

Variant ID Type Subtype PubMed ID
nsv870975 CNV Loss 21882294
nsv834524 CNV Gain+Loss 17160897

Variation tolerance for ZDHHC18 Gene

Residual Variation Intolerance Score: 35.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.30; 41.05% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZDHHC18 Gene

Disorders for ZDHHC18 Gene

Relevant External Links for ZDHHC18

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZDHHC18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC18 Gene

Publications for ZDHHC18 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system. (PMID: 23034182) Ohno Y. … Kihara A. (Mol. Biol. Cell 2012) 3
  4. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. (PMID: 16647879) Ohno Y. … Igarashi Y. (Biochim. Biophys. Acta 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ZDHHC18 Gene

Sources for ZDHHC18 Gene