ZDHHC18 Gene
protein-coding GIFtS: 47
GCID: GC01P027153
|
|
zinc finger, DHHC-type containing 18
| |
Aliases
for ZDHHC18 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger, DHHC-Type Containing 181 2 | | Palmitoyltransferase ZDHHC182 | | Zinc Finger DHHC Domain-Containing Protein 182 3 | | Zinc Finger, DHHC Domain Containing 182 | | DHHC-182 3 | | EC 2.3.1.-3 | | DKFZp667O24161 | | EC 2.3.18 | | DHHC182 | | |
Export aliases for ZDHHC18 gene to outside databasesPrevious GC identifers: GC01P026185 GC01P026386 GC01P026757 GC01P026837 GC01P027025 GC01P025406 |
Summaries
for ZDHHC18 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZDH18_HUMAN, Q9NUE0Function: Has palmitoyltransferase activity towards HRAS and LCK (By similarity)
|
Genomic Views
for ZDHHC18 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZDHHC18 gene promoter:
E2F-3a SRF SRF (504 AA) E2F-2 AP-4 LCR-F1 YY1 Pax-3 E2F E2F-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZDHHC18
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZDHHC18 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.11 Ensembl cytogenetic band: 1p36.11 HGNC cytogenetic band: 1p36.11ZDHHC18 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P027153: view genomic region
(about GC identifiers)
Start:
|
27,153,201 bp from pter |
End:
|
27,183,391 bp from pter |
Size:
|
30,191 bases |
Orientation:
|
plus strand |
|
Proteins
for ZDHHC18 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZDH18_HUMAN, Q9NUE0 (See
protein sequence)Recommended Name: Palmitoyltransferase ZDHHC18 Size: 388 amino acids; 42031 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=CAI21624.1; Type=Erroneous initiation;
Secondary accessions: A6NHY9 Q5JYH0 Q9H020Explore the universe of human proteins at neXtProt for ZDHHC18: NX_Q9NUE0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NUE0
4/8 DME Specific Peptides for ZDHHC18 (Q9NUE0) (see all 8)
ZDHHC18 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115659.1
ENSEMBL proteins: ENSP00000363257 ENSP00000363256 ENSP00000435510 ENSP00000436203
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
ZDHHC18 for ontologies About GeneDecksing
ZDHHC18 Antibody Products:
Assay Products for ZDHHC18: |
Protein
Domains /
Families
for ZDHHC18 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZDHHC18 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NUE0ProtoNet protein and cluster: Q9NUE0 1 Blocks protein family: IPB001594 Zn-finger
UniProtKB/Swiss-Prot: ZDH18_HUMAN, Q9NUE0Domain: The DHHC domain is required for palmitoyltransferase activity (By similarity)Similarity: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamilySimilarity: Contains 1 DHHC-type zinc finger |
Function
for ZDHHC18 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZDH18_HUMAN, Q9NUE0Function: Has palmitoyltransferase activity towards HRAS and LCK (By similarity)Catalytic activity: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoAEnzyme Numbers (IUBMB): EC 2.3.12 EC 2.3.1.-1
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC18
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC18 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- | | GO:0016409 | palmitoyltransferase activity |
IEA | -- |
ZDHHC18 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZDHHC18:
|
Pathways & Interactions
for ZDHHC18 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZDHHC18
2 Interacting proteins for ZDHHC18 (Q9NUE03) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0034613 | cellular protein localization |
IEA | -- |
ZDHHC18 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZDHHC18 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZDHHC18
Search CenterWatch for drugs/clinical trials and news about ZDHHC18 / ZDH18
|
Transcripts
for ZDHHC18 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZDHHC18 gene: NM_032283.2 Unigene Cluster for ZDHHC18: Zinc finger, DHHC-type containing 18 Hs.523710 [show with all ESTs]Unigene Representative Sequence: NM_0322835 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000374142(uc001bnb.3) ENST00000374141(uc010ofh.1) ENST00000534643
ENST00000488397 ENST00000478902
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC18 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC18
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZDHHC18 (NM_032283) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZDHHC18 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZDHHC18 |
Additional cDNA sequence: AK056427.1 AK091260.1 AK298683.1 AL512765.1 BC066776.1 10 DOTS entries: DT.451819 DT.101969354 DT.422346 DT.99993284 DT.100784619 DT.121398875 DT.99985018 DT.100784620 DT.121398834 DT.99968931 24/197 AceView cDNA sequences (see all 197): CB529912 AI739298 BM679985 BC066776 AK056427 BQ063758 AI745525 BE550169 CB852692 CR600621 AI151381 CD671312 AL512765 CB147711 AI401027 Z45373 AI369370 BM932323 BI868296 BF512598 AI922342 BM929476 AA926756 BE676622
GeneLoc Exon Structure
|
Expression
for ZDHHC18 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZDHHC18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGCCCTGT
About this image
See ZDHHC18 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZDHHC18
SOURCE GeneReport for Unigene cluster: Hs.523710
SABiosciences Custom PCR Arrays for ZDHHC18
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZDHHC18
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC18 |
Orthologs
for ZDHHC18 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ZDHHC18 gene from 7/24 species (see all 24) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ZDHHC186 |
zinc finger, DHHC-type containing 18 |
79(a) |
1 ↔ 1 |
23(1744441-1752464) |
lizard
(Anolis carolinensis) |
Reptilia |
ZDHHC186ZDHHC196 |
-- |
73(a)26(a) |
1 ↔ 1possible ortholog |
GL343488.1(122613-136994) GL343887.1(115529-119232) |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.91652 |
Danio rerio mRNA similar to zinc finger, DHHC domain more |
75.61(n) |
|
BC045475.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
app1 |
approximated |
60.98(n)
62.88(a) |
|
39399 NM_140304.5 NP_648561.2 |
worm
(Caenorhabditis elegans) |
Secernentea |
dhhc-26 |
DHHC-types zinc finger transcription factor family... |
36(a) |
possible ortholog |
I(11836451-11849238) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT3G269351 |
putative S-acyltransferase |
47.78(n)
40.33(a) |
|
822311 NM_180307.3 NP_850638.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.172952 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
74.05(n) |
|
AK121806.1 |
ENSEMBL Gene Tree for ZDHHC18 (if available)
TreeFam Gene Tree for ZDHHC18 (if available) |
Paralogs
for ZDHHC18 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZDHHC18 gene
- ZDHHC142 ZDHHC52 ZDHHC122 ZDHHC82 ZDHHC192 ZDHHC92
9 SIMAP similar genes for ZDHHC18 using alignment to 4 protein entries: ZDH18_HUMAN (see all proteins):ZDHHC14 ZDHHC5 ZDHHC2 ZDHHC9 ZDHHC8 ZDHHC11B
ZDHHC1 ZDHHC3 ZDHHC7
ZDHHC18 for paralogs About GeneDecksing
|
Genomic Variants
for ZDHHC18 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZDHHC18 (27153201 - 27183391 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZDHHC18
1 CNV: 4218 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZDHHC18 |
|
Disorders
/ Diseases
for ZDHHC18 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZDHHC18 for disorders About GeneDecksing
1  disease for ZDHHC18: About MalaCardsmalaria
Export disorders for ZDHHC18 gene to outside databases
|
Publications
for ZDHHC18 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZDHHC18 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZDHHC18) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZDHHC18 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZDHHC18 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZDHHC18 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZDHHC18 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZDHHC18 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZDHHC18 gene:
Search GeneIP for patents involving ZDHHC18
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZDHHC18 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| |
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 | | | ZDHHC18 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC18 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZDHHC18 |
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