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Aliases for ZDHHC18 Gene

Aliases for ZDHHC18 Gene

  • Zinc Finger, DHHC-Type Containing 18 2 3
  • Zinc Finger DHHC Domain-Containing Protein 18 3 4
  • DHHC-18 3 4
  • Zinc Finger, DHHC Domain Containing 18 3
  • Palmitoyltransferase ZDHHC18 3
  • EC 2.3.1.225 4
  • EC 2.3.1 63
  • DHHC18 3

External Ids for ZDHHC18 Gene

Summaries for ZDHHC18 Gene

GeneCards Summary for ZDHHC18 Gene

ZDHHC18 (Zinc Finger, DHHC-Type Containing 18) is a Protein Coding gene. GO annotations related to this gene include palmitoyltransferase activity. An important paralog of this gene is ZDHHC4.

UniProtKB/Swiss-Prot for ZDHHC18 Gene

  • Has palmitoyltransferase activity towards HRAS and LCK.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC18 Gene

Genomics for ZDHHC18 Gene

Genomic Location for ZDHHC18 Gene

Start:
26,826,710 bp from pter
End:
26,857,602 bp from pter
Size:
30,893 bases
Orientation:
Plus strand

Genomic View for ZDHHC18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZDHHC18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC18 Gene

Regulatory Elements for ZDHHC18 Gene

Proteins for ZDHHC18 Gene

  • Protein details for ZDHHC18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUE0-ZDH18_HUMAN
    Recommended name:
    Palmitoyltransferase ZDHHC18
    Protein Accession:
    Q9NUE0
    Secondary Accessions:
    • A6NHY9
    • B4DQ84
    • Q5JYH0
    • Q9H020

    Protein attributes for ZDHHC18 Gene

    Size:
    388 amino acids
    Molecular mass:
    42031 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI21624.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZDHHC18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZDHHC18 Gene

Proteomics data for ZDHHC18 Gene at MOPED

Selected DME Specific Peptides for ZDHHC18 Gene

Post-translational modifications for ZDHHC18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZDHHC18 Gene

Domains for ZDHHC18 Gene

Gene Families for ZDHHC18 Gene

HGNC:
  • ZDHHC :Zinc fingers, DHHC-type

Protein Domains for ZDHHC18 Gene

Suggested Antigen Peptide Sequences for ZDHHC18 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NUE0

UniProtKB/Swiss-Prot:

ZDH18_HUMAN
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.:
    • Q9NUE0
Family:
  • Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.:
    • Q9NUE0
Similarity:
  • Contains 1 DHHC-type zinc finger.:
    • Q9NUE0
genes like me logo Genes that share domains with ZDHHC18: view

Function for ZDHHC18 Gene

Molecular function for ZDHHC18 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA
UniProtKB/Swiss-Prot Function: Has palmitoyltransferase activity towards HRAS and LCK.

Enzyme Numbers (IUBMB) for ZDHHC18 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016409 palmitoyltransferase activity IDA 23034182
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC18: view

Phenotypes for ZDHHC18 Gene

GenomeRNAi human phenotypes for ZDHHC18:
genes like me logo Genes that share phenotypes with ZDHHC18: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZDHHC18 Gene

Localization for ZDHHC18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC18 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZDHHC18 Gene COMPARTMENTS Subcellular localization image for ZDHHC18 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ZDHHC18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IDA 16647879
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC18: view

Pathways for ZDHHC18 Gene

SuperPathways for ZDHHC18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0018345 protein palmitoylation IDA 23034182
GO:0034613 cellular protein localization IEA --
genes like me logo Genes that share ontologies with ZDHHC18: view

No data available for Pathways by source for ZDHHC18 Gene

Transcripts for ZDHHC18 Gene

Unigene Clusters for ZDHHC18 Gene

Zinc finger, DHHC-type containing 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC18 Gene

No ASD Table

Relevant External Links for ZDHHC18 Gene

GeneLoc Exon Structure for
ZDHHC18
ECgene alternative splicing isoforms for
ZDHHC18

Expression for ZDHHC18 Gene

mRNA expression in normal human tissues for ZDHHC18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZDHHC18 Gene

This gene is overexpressed in Whole Blood (18.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZDHHC18 Gene

SOURCE GeneReport for Unigene cluster for ZDHHC18 Gene Hs.523710

genes like me logo Genes that share expressions with ZDHHC18: view

No data available for mRNA Expression by UniProt/SwissProt for ZDHHC18 Gene

Orthologs for ZDHHC18 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZDHHC18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC18 35
  • 99.34 (n)
  • 99.61 (a)
cow
(Bos Taurus)
Mammalia ZDHHC18 35
  • 89.77 (n)
  • 90.42 (a)
ZDHHC18 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZDHHC18 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zdhhc18 35
  • 90.09 (n)
  • 94.74 (a)
Zdhhc18 16
Zdhhc18 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZDHHC18 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC18 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zdhhc18 35
  • 89.15 (n)
  • 94.01 (a)
chicken
(Gallus gallus)
Aves ZDHHC18 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZDHHC18 36
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii Dr.9165 35
zdhhc18a 35
  • 66.57 (n)
  • 71.43 (a)
zdhhc18b 36
  • 71 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005111 35
  • 60.27 (n)
  • 62.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta app 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dhhc-2 36
  • 36 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G50020 35
  • 47.12 (n)
  • 41.36 (a)
rice
(Oryza sativa)
Liliopsida Os.17295 35
Os01g0868200 35
  • 47.77 (n)
  • 40.55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3762 36
  • 52 (a)
OneToMany
Species with no ortholog for ZDHHC18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZDHHC18 Gene

ENSEMBL:
Gene Tree for ZDHHC18 (if available)
TreeFam:
Gene Tree for ZDHHC18 (if available)

Paralogs for ZDHHC18 Gene

Selected SIMAP similar genes for ZDHHC18 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZDHHC18: view

Variants for ZDHHC18 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC18 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs737524 -- 26,854,338(+) CCTTT(A/C)TTCTG utr-variant-3-prime
rs760092 -- 26,854,898(+) TCCCA(G/T)ATCCC utr-variant-3-prime
rs760093 -- 26,854,936(+) TGAGT(A/G)TCAGA utr-variant-3-prime
rs1055223 -- 26,832,510(-) ACGAA(A/G)AAGAA reference, synonymous-codon
rs1055225 -- 26,832,507(-) AAGAA(A/G)AAGAG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC18 Gene

Variant ID Type Subtype PubMed ID
nsv870975 CNV Loss 21882294
nsv834524 CNV Gain+Loss 17160897

Relevant External Links for ZDHHC18 Gene

HapMap Linkage Disequilibrium report
ZDHHC18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC18 Gene

Disorders for ZDHHC18 Gene

No disorders were found for ZDHHC18 Gene.

No data available for UniProtKB/Swiss-Prot for ZDHHC18 Gene

Publications for ZDHHC18 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system. (PMID: 23034182) Ohno Y. … Kihara A. (Mol. Biol. Cell 2012) 3
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4

Products for ZDHHC18 Gene

  • antibodies-online peptides for ZDHHC18
  • antibodies-online antibodies for ZDHHC18
  • antibodies-online kits for ZDHHC18

Sources for ZDHHC18 Gene

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