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ZDHHC17 Gene

protein-coding   GIFtS: 56
GCID: GC12P077157

Zinc Finger, DHHC-Type Containing 17

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, DHHC-Type Containing 171 2     HIP-32 3
HIP142 3 5     HIP32 3
Huntingtin Yeast Partner H2 3     HYPH2 3
Huntingtin-Interacting Protein 142 3     Huntingtin Interacting Protein 142
Huntingtin-Interacting Protein 32 3     Huntingtin Interacting Protein 32
Huntingtin-Interacting Protein H2 3     Huntingtin Interacting Protein H2
Putative MAPK-Activating Protein PM112 3     Palmitoyltransferase ZDHHC172
Putative NF-Kappa-B-Activating Protein 2052 3     Zinc Finger, DHHC Domain Containing 172
Zinc Finger DHHC Domain-Containing Protein 172 3     EC 2.3.1.2253
DHHC-172 3     KIAA09463
HIP-142 3     EC 2.3.18

External Ids:    HGNC: 184121   Entrez Gene: 233902   Ensembl: ENSG000001869087   OMIM: 6077995   UniProtKB: Q8IUH53   

Export aliases for ZDHHC17 gene to outside databases

Previous GC identifers: GC12P075660 GC12P075681 GC12P074210


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZDHHC17 Gene:
ZDHHC17 (zinc finger, DHHC-type containing 17) is a protein-coding gene. Diseases associated with ZDHHC17 include brain injury, and huntington's disease. GO annotations related to this gene include protein-cysteine S-palmitoyltransferase activity and signal transducer activity. An important paralog of this gene is ZDHHC12.

UniProtKB/Swiss-Prot: ZDH17_HUMAN, Q8IUH5
Function: Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2,
SYT1 and HD. Palmitoylates MPP1 in erythrocytes. May be involved in the sorting or targeting of critical proteins
involved in the initiating events of endocytosis at the plasma membrane. Has transforming activity. Mediates
Mg(2+) transport

Gene Wiki entry for ZDHHC17 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZDHHC17 gene promoter:
         Spz1   ATF-2   Nkx2-5   CUTL1   Roaz   POU2F1   FOXJ2 (long isoform)   POU2F1a   HSF2   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZDHHC17 promoter sequence
   Search Chromatin IP Primers for ZDHHC17

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZDHHC17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q21.2   Ensembl cytogenetic band:  12q21.2   HGNC cytogenetic band: 12q21.2

ZDHHC17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZDHHC17 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P077157:  view genomic region     (about GC identifiers)

Start:
77,157,368 bp from pter      End:
77,247,476 bp from pter
Size:
90,109 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZDH17_HUMAN, Q8IUH5 (See protein sequence)
Recommended Name: Palmitoyltransferase ZDHHC17  
Size: 632 amino acids; 72640 Da
Subunit: Interacts (via ANK repeats) with HD. This interaction is inversely correlated to the length of the
polyglutamine tract added to the huntingtin protein in Huntington disease
Miscellaneous: The early and prominent pathology of HD is observed in the medium spiny neurons that project into
the globus
Sequence caution: Sequence=AAF28972.1; Type=Frameshift; Positions=183, 191; Sequence=AAH30990.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened; Sequence=BAA76790.1; Type=Erroneous initiation;
Note=Translation N-terminally shortened; Sequence=BAC77366.1; Type=Erroneous initiation; Note=Translation
N-terminally extended; Sequence=BAC77388.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for ZDHHC17:
3EU9 (3D)    
Secondary accessions: B4DR39 O75407 Q7Z2I0 Q86W89 Q86YK0 Q9P088 Q9UPZ8
Alternative splicing: 3 isoforms:  Q8IUH5-1   Q8IUH5-2   Q8IUH5-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZDHHC17: NX_Q8IUH5

Explore proteomics data for ZDHHC17 at MOPED

Post-translational modifications: 

  • Autopalmitoylated. Autopalmitoylation has a regulatory role in ZDHHC17-mediated Mg(2+) transport1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for ZDHHC17 (Q8IUH5)
     LHWAAIN  LAETGSLD 


    See ZDHHC17 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056151.2  
    ENSEMBL proteins: 
     ENSP00000403397   ENSP00000447871   ENSP00000449551   ENSP00000446954   ENSP00000449734  
     ENSP00000447934   ENSP00000449728   ENSP00000449836   ENSP00000450295   ENSP00000448757  
     ENSP00000334868   ENSP00000351913  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing
    ZDHHC: Zinc fingers, DHHC-type

    3 InterPro protein domains:
     IPR001594 Znf_DHHC_palmitoyltrfase
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q8IUH5

    ProtoNet protein and cluster: Q8IUH5

    2 Blocks protein domains:
    IPB001594 Zn-finger
    IPB002110 Ankyrin repeat signature


    UniProtKB/Swiss-Prot: ZDH17_HUMAN, Q8IUH5
    Domain: The DHHC domain is required for palmitoyltransferase activity
    Similarity: Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily
    Similarity: Contains 5 ANK repeats
    Similarity: Contains 1 DHHC-type zinc finger


    ZDHHC17 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZDH17_HUMAN, Q8IUH5
    Function: Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2,
    SYT1 and HD. Palmitoylates MPP1 in erythrocytes. May be involved in the sorting or targeting of critical proteins
    involved in the initiating events of endocytosis at the plasma membrane. Has transforming activity. Mediates
    Mg(2+) transport
    Catalytic activity: Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA
    Biophysicochemical properties: Kinetic parameters: KM=0.87 mM for for magnesium ions;

         Enzyme Numbers (IUBMB): EC 2.3.1.2251 EC 2.3.12

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IMP12761501
    GO:0005515protein binding IPI15603740
    GO:0008270zinc ion binding IEA--
    GO:0015095magnesium ion transmembrane transporter activity IDA18794299
    GO:0016409palmitoyltransferase activity IDA--
         
    ZDHHC17 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Zdhhc17):
     behavior/neurological  cellular  growth/size/body  nervous system 

    ZDHHC17 for phenotypes           About GeneDecksing

    Animal Models:
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    miRTarBase miRNAs that target ZDHHC17:
    hsa-mir-148b-3p (MIRT019308), hsa-mir-30b-5p (MIRT023433)

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    Selected qRT-PCR Assays for microRNAs that regulate ZDHHC17 (see all 54):
    hsa-miR-411* hsa-miR-562 hsa-miR-3607-3p hsa-miR-379* hsa-miR-429 hsa-miR-548k hsa-miR-30d hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmidZDHHC17 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZDHHC17

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZDH17_HUMAN, Q8IUH5: Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane;
    Multi-pass membrane protein. Note=Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi membrane
    vesicles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytosol3
    plasma membrane3
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IDA18794299
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0016021integral component of membrane IEA--
    GO:0030660Golgi-associated vesicle membrane IDA18794299

    ZDHHC17 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZDHHC17
    Interactions:

        GeneGlobe Interaction Network for ZDHHC17

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ZDHHC17 (Q8IUH51, 3 ENSP000004033974) via UniProtKB, MINT, STRING, and/or I2D (see all 89)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HTTP428581, 3, ENSP000003471844EBI-524753,EBI-466029 I2D: score=4 STRING: ENSP00000347184
    SNAP25P608801, 3, ENSP000002549764EBI-524753,EBI-524785 I2D: score=3 STRING: ENSP00000254976
    ARFGAP1Q8N6T33, ENSP000003146154I2D: score=3 STRING: ENSP00000314615
    NFYCQ139523, ENSP000003966204I2D: score=3 STRING: ENSP00000396620
    COG3Q96JB23, ENSP000002586544I2D: score=2 STRING: ENSP00000258654
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IMP12761501
    GO:0015693magnesium ion transport IDA18794299
    GO:0018345protein palmitoylation IDA--
    GO:0042953lipoprotein transport IDA15603740
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling IMP12761501

    ZDHHC17 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZDHHC17 (ZDH17)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZDHHC17 gene: 
    NM_015336.2  

    Unigene Cluster for ZDHHC17:

    Zinc finger, DHHC-type containing 17
    Hs.4014  [show with all ESTs]
    Unigene Representative Sequence: AB024494
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000426126(uc001syk.1) ENST00000546778(uc001syj.2) ENST00000552453
    ENST00000547620 ENST00000550876 ENST00000551407 ENST00000547604 ENST00000550163
    ENST00000549682 ENST00000549944 ENST00000549010 ENST00000550789 ENST00000552693
    ENST00000553091 ENST00000550244 ENST00000547673 ENST00000334822(uc001syi.1)
    ENST00000359019
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    Selected qRT-PCR Assays for microRNAs that regulate ZDHHC17 (see all 54):
    hsa-miR-411* hsa-miR-562 hsa-miR-3607-3p hsa-miR-379* hsa-miR-429 hsa-miR-548k hsa-miR-30d hsa-miR-449a
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      QuantiTect SYBR Green Assays in human, mouse, rat ZDHHC17
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    Additional mRNA sequence: 

    AB023163.1 AB024494.1 AB097013.1 AB097035.1 AF049612.1 AF161412.1 AK292866.1 AK299089.1 
    BC030990.1 BC050324.1 

    14 DOTS entries:

    DT.445084  DT.100686546  DT.75174302  DT.121155837  DT.40130155  DT.40219623  DT.97763083  DT.99954651 
    DT.100740999  DT.100785790  DT.102820272  DT.121155823  DT.99996097  DT.91923366 

    Selected AceView cDNA sequences (see all 161):

    AF049612 BX951365 BC030990 BG572873 AA463321 AL698808 AI683377 BP872893 
    BX444645 BM720173 AL698819 AI926521 BG035196 BM698484 BX500972 AB023163 
    AA768049 AB097013 AB097035 C04778 AI949352 BM667408 BE349275 R15825 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC17 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a ·
    SP1:        -                                               -                                         -                             -           -               
    SP2:        -     -                                                                                                                                             
    SP3:                                                                                                                                                            
    SP4:                                                                                            -     -     -     -     -     -     -     -     -     -     -   
    SP5:                                                                                                                                            -               

    ExUns: 18b · 18c ^ 19 ^ 20a · 20b
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for ZDHHC17

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZDHHC17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTACTTCC
    ZDHHC17 Expression
    About this image

    ZDHHC17 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZDHHC17 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.4014

    UniProtKB/Swiss-Prot: ZDH17_HUMAN, Q8IUH5
    Tissue specificity: Expressed in all brain regions. Expression is highest in the cortex, cerebellum, occipital
    lobe and caudate and lowest in the spinal cord. Expression is also seen in testis, pancreas, heart and kidney.
    ZDHHC17 is the only palmitoyltransferase in erythrocytes

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ZDHHC17 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zdhhc171 , 5 zinc finger, DHHC domain containing 171, 5 92.25(n)1
    98.58(a)1
      10 (57.86 cM)5
    3201501  NM_172554.21  NP_766142.21 
     1109417825 
    chicken
    (Gallus gallus)
    Aves ZDHHC171 zinc finger, DHHC-type containing 17 86.44(n)
    96.62(a)
      417867  NM_001030745.1  NP_001025916.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZDHHC176
    zinc finger, DHHC-type containing 17
    95(a)
    1 ↔ 1
    5(40797125-40850942)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX773872.12   -- 80.34(n)    BX773872.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zdhhc171 zinc finger, DHHC-type containing 17 75.75(n)
    90.16(a)
      100148543  NM_001128382.1  NP_001121854.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hip141 Huntingtin-interacting protein 14 53.73(n)
    50.81(a)
      39747  NM_140567.3  NP_648824.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tag-2331 tag-233 45.65(n)
    32.53(a)
      181109  NM_001029343.2  NP_001024514.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AKR1(YDR264C)4
    AKR11
    Palmitoyl transferase involved in protein palmitoylation; more4
    AKR11
    45.16(n)1
    32.75(a)1
      4(998323-996029)4
    8518571, 4  NP_010550.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TIP11 TIP1 46.18(n)
    33.77(a)
      832157  NM_122042.3  NP_197535.2 
    rice
    (Oryza sativa)
    Liliopsida Os02g01840001 Os02g0184000 46.89(n)
    36.48(a)
      4328524  NM_001052640.1  NP_001046105.1 


    ENSEMBL Gene Tree for ZDHHC17 (if available)
    TreeFam Gene Tree for ZDHHC17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZDHHC17 gene
    ZDHHC122  ZDHHC132  
    5 SIMAP similar genes for ZDHHC17 using alignment to 10 protein entries:     ZDH17_HUMAN (see all proteins):
    ZDHHC13    EHMT1    ANK2    ANKMY2    ANKRD39

    ZDHHC17 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for ZDHHC17 (see all 1825)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs677892441,2
    C--74291657(+) TTTTT-/T/TT  
            
    GCAAG
    1 -- int11NA 2
    rs1385821891,2
    --77155874(+) AAAAAC/TACAAA 1 -- us2k10--------
    rs1492993531,2
    C--77155894(+) GCATGC/GTGGCG 1 -- us2k10--------
    rs3741587741,2
    C--77156028(+) AGTCT-/AAAAAAA 1 -- us2k10--------
    rs1141975601,2
    C,F--77156103(+) AATTCG/CATGCT 1 -- us2k11Minor allele frequency- C:0.09WA 118
    rs1444695031,2
    --77156148(+) AGATGA/GCTCCT 1 -- us2k10--------
    rs1887553601,2
    --77156224(+) GGGAGA/GACAGA 1 -- us2k10--------
    rs1484343511,2
    --77156240(+) AAAAAC/GCCAGC 1 -- us2k10--------
    rs596751221,2
    C,F--77156242(+) AAAGCC/TAGCAG 1 -- us2k12Minor allele frequency- T:0.15WA 120
    rs1813311501,2
    --77156296(+) GCTATG/TACACG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZDHHC17 (77157368 - 77247476 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZDHHC17:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv270980CNV Insertion20981092
    nsv899318CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZDHHC17
    DNA2.0 Custom Variant and Variant Library Synthesis for ZDHHC17

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607799    OMIM disorders: --

    5 diseases for ZDHHC17:    About MalaCards
    brain injury    huntington's disease    type 1 diabetes    neuronitis
    malaria

    1 disease from the University of Copenhagen DISEASES database for ZDHHC17:
    Huntington's disease

    ZDHHC17 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZDHHC17
    Human Genome Epidemiology (HuGE) Navigator: ZDHHC17 (1 document)

    Export disorders for ZDHHC17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZDHHC17 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with ZDHHC17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport. (PubMed id 18794299)1, 2, 3, 9 Goytain A.... Quamme G.A. (J. Biol. Chem. 2008)
    2. Huntingtin interacts with a family of WW domain proteins. (PubMed id 9700202)1, 2, 3 Faber P.W....MacDonald M.E. (Hum. Mol. Genet. 1998)
    3. HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis. (PubMed id 12393793)1, 2, 9 Singaraja R.R....Hayden M.R. (Hum. Mol. Genet. 2002)
    4. Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins. (PubMed id 15603740)1, 2, 9 Huang K.... El-Husseini A. (Neuron 2004)
    5. Huntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferase. (PubMed id 15489887)1, 2, 9 Ducker C.E.... Smith C.D. (Oncogene 2004)
    6. Genetic analysis of candidate genes modifying the age-at-onset in Huntington's disease. (PubMed id 16847693)1, 4, 9 Metzger S....Riess O. (Hum. Genet. 2006)
    7. The ankyrin repeat domain of Huntingtin interacting protein 14 contains a surface aromatic cage, a potential site for methyl-lysine binding. (PubMed id 19434754)1, 2, 9 Gao T.... Cheng X. (Proteins 2009)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PubMed id 12761501)1, 2 Matsuda A....Sugano S. (Oncogene 2003)
    10. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23390 HGNC: 18412 AceView: ZDHHC17 Ensembl:ENSG00000186908 euGenes: HUgn23390
    ECgene: ZDHHC17 H-InvDB: ZDHHC17

    (According to HUGE)
    About This Section

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    HUGE: KIAA0946

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ZDHHC17 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ZDHHC17 gene:
    Search GeneIP for patents involving ZDHHC17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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