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Aliases for ZDHHC17 Gene

Aliases for ZDHHC17 Gene

  • Zinc Finger, DHHC-Type Containing 17 2 3
  • HIP14 3 4 6
  • Zinc Finger DHHC Domain-Containing Protein 17 3 4
  • Putative NF-Kappa-B-Activating Protein 205 3 4
  • Putative MAPK-Activating Protein PM11 3 4
  • Huntingtin-Interacting Protein 14 3 4
  • Huntingtin-Interacting Protein 3 3 4
  • Huntingtin-Interacting Protein H 3 4
  • Huntingtin Yeast Partner H 3 4
  • DHHC-17 3 4
  • HIP-14 3 4
  • HIP-3 3 4
  • HIP3 3 4
  • HYPH 3 4
  • Zinc Finger, DHHC Domain Containing 17 3
  • Huntingtin Interacting Protein 14 3
  • Huntingtin Interacting Protein H 3
  • Huntingtin Interacting Protein 3 3
  • Palmitoyltransferase ZDHHC17 3
  • EC 2.3.1.225 4
  • KIAA0946 4
  • EC 2.3.1 64
  • HSPC294 3

External Ids for ZDHHC17 Gene

Summaries for ZDHHC17 Gene

GeneCards Summary for ZDHHC17 Gene

ZDHHC17 (Zinc Finger, DHHC-Type Containing 17) is a Protein Coding gene. GO annotations related to this gene include signal transducer activity and protein-cysteine S-palmitoyltransferase activity. An important paralog of this gene is ZDHHC13.

UniProtKB/Swiss-Prot for ZDHHC17 Gene

  • Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD. Palmitoylates MPP1 in erythrocytes. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. Has transforming activity. Mediates Mg(2+) transport.

Gene Wiki entry for ZDHHC17 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC17 Gene

Genomics for ZDHHC17 Gene

Genomic Location for ZDHHC17 Gene

Start:
76,763,588 bp from pter
End:
76,853,872 bp from pter
Size:
90,285 bases
Orientation:
Plus strand

Genomic View for ZDHHC17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZDHHC17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC17 Gene

Regulatory Elements for ZDHHC17 Gene

Proteins for ZDHHC17 Gene

  • Protein details for ZDHHC17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUH5-ZDH17_HUMAN
    Recommended name:
    Palmitoyltransferase ZDHHC17
    Protein Accession:
    Q8IUH5
    Secondary Accessions:
    • B4DR39
    • O75407
    • Q7Z2I0
    • Q86W89
    • Q86YK0
    • Q9P088
    • Q9UPZ8

    Protein attributes for ZDHHC17 Gene

    Size:
    632 amino acids
    Molecular mass:
    72640 Da
    Quaternary structure:
    • Interacts (via ANK repeats) with HD. This interaction is inversely correlated to the length of the polyglutamine tract added to the huntingtin protein in Huntington disease.
    Miscellaneous:
    • The early and prominent pathology of HD is observed in the medium spiny neurons that project into the globus
    SequenceCaution:
    • Sequence=AAF28972.1; Type=Frameshift; Positions=183, 191; Evidence={ECO:0000305}; Sequence=AAH30990.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA76790.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC77366.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC77388.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZDHHC17 Gene

    Alternative splice isoforms for ZDHHC17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZDHHC17 Gene

Proteomics data for ZDHHC17 Gene at MOPED

Selected DME Specific Peptides for ZDHHC17 Gene

Post-translational modifications for ZDHHC17 Gene

  • Autopalmitoylated. Autopalmitoylation has a regulatory role in ZDHHC17-mediated Mg(2+) transport
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for ZDHHC17 Gene

Gene Families for ZDHHC17 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing
  • ZDHHC :Zinc fingers, DHHC-type

UniProtKB/Swiss-Prot:

ZDH17_HUMAN
Domain:
  • The DHHC domain is required for palmitoyltransferase activity:
    • Q8IUH5
Family:
  • Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.:
    • Q8IUH5
Similarity:
  • Contains 7 ANK repeats.:
    • Q8IUH5
  • Contains 1 DHHC-type zinc finger.:
    • Q8IUH5
genes like me logo Genes that share domains with ZDHHC17: view

Function for ZDHHC17 Gene

Molecular function for ZDHHC17 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=0.87 mM for for magnesium ions;
UniProtKB/Swiss-Prot CatalyticActivity: Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA
UniProtKB/Swiss-Prot Function: Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD. Palmitoylates MPP1 in erythrocytes. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. Has transforming activity. Mediates Mg(2+) transport.

Enzyme Numbers (IUBMB) for ZDHHC17 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP 12761501
GO:0005515 protein binding IPI 15603740
GO:0008270 zinc ion binding IEA --
GO:0015095 magnesium ion transmembrane transporter activity IDA 18794299
GO:0016409 palmitoyltransferase activity IDA 23034182
genes like me logo Genes that share ontologies with ZDHHC17: view
genes like me logo Genes that share phenotypes with ZDHHC17: view

miRNA for ZDHHC17 Gene

miRTarBase miRNAs that target ZDHHC17

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ZDHHC17 Gene

Localization for ZDHHC17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC17 Gene

Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi membrane vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZDHHC17 Gene COMPARTMENTS Subcellular localization image for ZDHHC17 gene
Compartment Confidence
golgi apparatus 5
cytosol 3
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ZDHHC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IDA 18794299
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0016021 integral component of membrane IEA --
GO:0030660 Golgi-associated vesicle membrane IDA 18794299
genes like me logo Genes that share ontologies with ZDHHC17: view

Pathways for ZDHHC17 Gene

SuperPathways for ZDHHC17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IMP 12761501
GO:0015693 magnesium ion transport IEA --
GO:0018345 protein palmitoylation IDA 23034182
GO:0042953 lipoprotein transport IDA 15603740
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP 12761501
genes like me logo Genes that share ontologies with ZDHHC17: view

No data available for Pathways by source for ZDHHC17 Gene

Transcripts for ZDHHC17 Gene

Unigene Clusters for ZDHHC17 Gene

Zinc finger, DHHC-type containing 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC17 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a ·
SP1: - - - - -
SP2: - -
SP3:
SP4: - - - - - - - - - - -
SP5: -
SP6: -
SP7:

ExUns: 18b · 18c ^ 19 ^ 20a · 20b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for ZDHHC17 Gene

GeneLoc Exon Structure for
ZDHHC17
ECgene alternative splicing isoforms for
ZDHHC17

Expression for ZDHHC17 Gene

mRNA expression in normal human tissues for ZDHHC17 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZDHHC17 Gene

SOURCE GeneReport for Unigene cluster for ZDHHC17 Gene Hs.4014

mRNA Expression by UniProt/SwissProt for ZDHHC17 Gene

Q8IUH5-ZDH17_HUMAN
Tissue specificity: Expressed in all brain regions. Expression is highest in the cortex, cerebellum, occipital lobe and caudate and lowest in the spinal cord. Expression is also seen in testis, pancreas, heart and kidney. ZDHHC17 is the only palmitoyltransferase in erythrocytes.
genes like me logo Genes that share expressions with ZDHHC17: view

Orthologs for ZDHHC17 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZDHHC17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC17 36
  • 99.84 (n)
  • 100 (a)
ZDHHC17 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZDHHC17 36
  • 95.89 (n)
  • 99.37 (a)
ZDHHC17 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZDHHC17 36
  • 95.6 (n)
  • 98.53 (a)
ZDHHC17 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zdhhc17 36
  • 92.25 (n)
  • 98.58 (a)
Zdhhc17 16
Zdhhc17 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZDHHC17 37
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 96 (a)
OneToMany
-- 37
  • 88 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zdhhc17 36
  • 92.93 (n)
  • 98.55 (a)
chicken
(Gallus gallus)
Aves ZDHHC17 36
  • 86.44 (n)
  • 96.62 (a)
ZDHHC17 37
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZDHHC17 37
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc17 36
  • 81.4 (n)
  • 94.86 (a)
zebrafish
(Danio rerio)
Actinopterygii zdhhc17 36
  • 75.75 (n)
  • 90.16 (a)
zdhhc17 37
  • 90 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011732 36
  • 53.17 (n)
  • 52.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hip14 36
  • 53.73 (n)
  • 50.81 (a)
Hip14 37
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-233 36
  • 45.65 (n)
  • 32.53 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER388C 36
  • 45.23 (n)
  • 33.92 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AKR1 36
  • 45.16 (n)
  • 32.75 (a)
AKR1 37
  • 22 (a)
ManyToMany
AKR2 37
  • 20 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E16721g 36
  • 44.39 (n)
  • 32.71 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons TIP1 36
  • 46.18 (n)
  • 33.77 (a)
rice
(Oryza sativa)
Liliopsida Os02g0184000 36
  • 46.89 (n)
  • 36.48 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08218 36
  • 42.63 (n)
  • 32.66 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes akr1 36
  • 44.6 (n)
  • 33.01 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11093 37
  • 47 (a)
OneToMany
Species with no ortholog for ZDHHC17:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC17 Gene

ENSEMBL:
Gene Tree for ZDHHC17 (if available)
TreeFam:
Gene Tree for ZDHHC17 (if available)

Paralogs for ZDHHC17 Gene

Paralogs for ZDHHC17 Gene

genes like me logo Genes that share paralogs with ZDHHC17: view

Variants for ZDHHC17 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC17 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs10667 -- 76,853,370(+) CAACT(C/T)AATTG utr-variant-3-prime
rs702062 -- 76,851,969(-) GTACT(C/T)AGATC utr-variant-3-prime
rs702063 -- 76,851,970(-) TGTAC(A/T)TAGAT utr-variant-3-prime
rs937307 -- 76,844,447(-) GCCCA(G/T)GCTGG intron-variant
rs1017784 -- 76,764,639(-) AAACC(A/G)CACCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC17 Gene

Variant ID Type Subtype PubMed ID
nsv899318 CNV Loss 21882294
esv270980 CNV Insertion 20981092

Relevant External Links for ZDHHC17 Gene

HapMap Linkage Disequilibrium report
ZDHHC17

Disorders for ZDHHC17 Gene

(1) University of Copenhagen DISEASES for ZDHHC17 Gene

Relevant External Links for ZDHHC17

Genetic Association Database (GAD)
ZDHHC17
Human Genome Epidemiology (HuGE) Navigator
ZDHHC17
genes like me logo Genes that share disorders with ZDHHC17: view

No data available for UniProtKB/Swiss-Prot for ZDHHC17 Gene

Publications for ZDHHC17 Gene

  1. Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport. (PMID: 18794299) Goytain A. … Quamme G.A. (J. Biol. Chem. 2008) 2 3 4 23
  2. The ankyrin repeat domain of Huntingtin interacting protein 14 contains a surface aromatic cage, a potential site for methyl-lysine binding. (PMID: 19434754) Gao T. … Cheng X. (Proteins 2009) 3 4 23
  3. Huntingtin interacts with a family of WW domain proteins. (PMID: 9700202) Faber P.W. … MacDonald M.E. (Hum. Mol. Genet. 1998) 2 3 4
  4. HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis. (PMID: 12393793) Singaraja R.R. … Hayden M.R. (Hum. Mol. Genet. 2002) 3 4 23
  5. Huntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferase. (PMID: 15489887) Ducker C.E. … Smith C.D. (Oncogene 2004) 3 4 23

Products for ZDHHC17 Gene

Sources for ZDHHC17 Gene

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