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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZDHHC16 Gene

protein-coding   GIFtS: 47
GCID: GC10P099195

zinc finger, DHHC-type containing 16

 Explore 2 diseases affiliated with
ZDHHC16 via our new
 Human Malady Compendium 
Biological research products
for ZDHHC16
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger, DHHC-Type Containing 161 2     Probable Palmitoyltransferase ZDHHC162
APH21 2     Zinc Finger, DHHC Domain Containing 162
Zinc Finger DHHC Domain-Containing Protein 162 3     EC 2.3.1.-3
DHHC-162 3     EC 2.3.18
Abl-Philin 22     

External Ids:    HGNC: 207141   Entrez Gene: 842872   Ensembl: ENSG000001713077   UniProtKB: Q969W13   

Export aliases for ZDHHC16 gene to outside databases

Previous GC identifers: GC10P098439 GC10P099337 GC10P098870 GC10P092831


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZDH16_HUMAN, Q969W1
Function: May be involved in apoptosis regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZDHHC16 gene promoter:
         SRY   AML1a   Tal-1beta   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZDHHC16 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZDHHC16

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZDHHC16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.1   Ensembl cytogenetic band:  10q24.1   HGNC cytogenetic band: 10q24.1

ZDHHC16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZDHHC16 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P099195:  view genomic region     (about GC identifiers)

Start:
99,205,927 bp from pter      End:
99,217,127 bp from pter
Size:
11,201 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZDH16_HUMAN, Q969W1 (See protein sequence)
Recommended Name: Probable palmitoyltransferase ZDHHC16  
Size: 377 amino acids; 43633 Da
Subunit: Interacts with ABL1 (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: D3DR52 D3DR53 D3DR54 Q5JTG7 Q5JTH0 Q8N4Z6 Q8WY84 Q9BSV3
Alternative splicing: 4 isoforms:  Q969W1-1   Q969W1-2   Q969W1-3   Q969W1-4   

Explore the universe of human proteins at neXtProt for ZDHHC16: NX_Q969W1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q969W1

  • 4/12 DME Specific Peptides for ZDHHC16 (Q969W1) (see all 12)
     WLNNCVG  MDHHCPW  TVSICKKCI  CVLKMDHHC 

    ZDHHC16 Protein expression data from MOPED and PaxDb:    About this image 
    ZDHHC16 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_115703.2  NP_932160.1  NP_932161.1  NP_932162.1  NP_932163.1  

    ENSEMBL proteins: 
     ENSP00000359891   ENSP00000400719   ENSP00000359883   ENSP00000345383   ENSP00000323360  
     ENSP00000359879   ENSP00000304487   ENSP00000398532   ENSP00000405240   ENSP00000396286  
     ENSP00000377357  

    Human Recombinant Protein Products for ZDHHC16: 
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    Uscn Proteins for ZDHHC16

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--

    ZDHHC16 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZDHHC16 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001594 Znf_DHHC_palmitoyltrfase

    Graphical View of Domain Structure for InterPro Entry Q969W1

    ProtoNet protein and cluster: Q969W1

    1 Blocks protein family: IPB001594 Zn-finger

    UniProtKB/Swiss-Prot: ZDH16_HUMAN, Q969W1
    Domain: The DHHC domain is required for palmitoyltransferase activity (By similarity)
    Similarity: Belongs to the DHHC palmitoyltransferase family
    Similarity: Contains 1 DHHC-type zinc finger


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZDH16_HUMAN, Q969W1
    Function: May be involved in apoptosis regulation (By similarity)
    Catalytic activity: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA

         Enzyme Numbers (IUBMB): EC 2.3.12 EC 2.3.1.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
    GO:0016746transferase activity, transferring acyl groups IEA--
         
    ZDHHC16 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ZDHHC16:
     Increased HPV18 LCR reporter a  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ZDHHC16 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC16


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZDHHC16

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for ZDHHC16 (Q969W13 ENSP000003598914) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005193, ENSP000003614234I2D: score=2 STRING: ENSP00000361423
    HOXA2O433643I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--

    ZDHHC16 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZDHHC16
    Search CenterWatch for drugs/clinical trials and news about ZDHHC16 / ZDH16 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZDHHC16 gene (5 alternative transcripts): 
    NM_032327.2  NM_198043.1  NM_198044.1  NM_198045.1  NM_198046.1  

    Unigene Cluster for ZDHHC16:

    Zinc finger, DHHC-type containing 16
    Hs.76662  [show with all ESTs]
    Unigene Representative Sequence: AB209272
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370854(uc001knk.3 uc001knl.3 uc001knm.3 uc001knn.3)
    ENST00000414567 ENST00000459777 ENST00000466895 ENST00000370846 ENST00000352634
    ENST00000353979 ENST00000370842 ENST00000345745 ENST00000462924 ENST00000433086
    ENST00000492610 ENST00000495735 ENST00000420089 ENST00000417044 ENST00000487315
    ENST00000492733 ENST00000393760(uc001knj.3 uc010qow.2)

    miRNA
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    Additional cDNA sequence: 

    AB209272.1 AF258563.1 AJ294945.1 AK074427.1 AK297962.1 AY359080.1 BC004535.2 BC008074.2 
    BC011749.2 BC012830.2 BC033157.1 

    24/30 DOTS entries (see all 30):

    DT.100881446  DT.100881445  DT.97791878  DT.100881450  DT.75172954  DT.415742  DT.100881443  DT.100881454 
    DT.100881444  DT.95091515  DT.121278617  DT.95188805  DT.95091506  DT.121278494  DT.121278673  DT.100718186 
    DT.100659524  DT.91662225  DT.100656837  DT.100662493  DT.100671404  DT.121278601  DT.121278602  DT.95091488 

    24/312 AceView cDNA sequences (see all 312):

    T31351 BE315244 AY359080 BE879163 NM_198045 BX353685 CR593129 AI190823 
    BC008074 T64516 AI986434 CR614608 AI696261 AI925426 BC004535 BG121594 
    AF258563 CB240790 BI914390 AW952610 CR620516 BI090267 AA337175 BM544464 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC16 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ·
    SP1:                                -     -                                         -                                         -                                 
    SP2:                          -     -     -                                         -                                         -                                 
    SP3:                          -     -     -                                         -                             -           -                                 
    SP4:                          -     -     -                                         -     -     -     -                       -                                 
    SP5:                          -     -     -                 -     -                 -                             -           -                                 

    ExUns: 14c
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for ZDHHC16

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZDHHC16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGCTTAAGG
    ZDHHC16 Expression
    About this image
    See ZDHHC16 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZDHHC16

    SOURCE GeneReport for Unigene cluster: Hs.76662
        SABiosciences Custom PCR Arrays for ZDHHC16

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC16

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ZDHHC16 gene from 8/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ZDHHC161 zinc finger, DHHC-type containing 16 74.22(n)
    71.47(a)
      423843  XM_421711.3  XP_421711.3 
    lizard
    (Anolis carolinensis)
    Reptilia ZDHHC166
    --
    67(a)
    1 ↔ 1
    GL343810.1(68857-76396)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.190942 Transcribed sequence with moderate similarity to protein more 75.22(n)    BX773791.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc639342 hypothetical protein MGC63934 77.11(n)   393316  BC053155.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG58801 CG5880 52.13(n)
    46.95(a)
      43268  NM_143282.3  NP_651539.3 
    worm
    (Caenorhabditis elegans)
    Secernentea C43H6.71 Protein C43H6.7 42.98(n)
    31.95(a)
      183426  NM_076034.3  NP_508435.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G186206
    putative S-acyltransferase
    16(a)
    1 ↔ 1
    3(6408318-6411064)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    DHHC zinc finger domain containing protein, expres...
    DHHC zinc finger domain containing protein, expres...
    18(a)
    15(a)
    possible ortholog
    possible ortholog
    4(34242688-34246562)
    6(11717879-11721903)


    ENSEMBL Gene Tree for ZDHHC16 (if available)
    TreeFam Gene Tree for ZDHHC16 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZDHHC16 gene
    ZDHHC62  

    ZDHHC16 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/157 NCBI SNPs in ZDHHC16 are shown (see all 157    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1133081281,2
    --99207799(+) ACTTTG/CTTCAC 5 -- int11Minor allele frequency- C:0.50CSA 2
    rs1901695971,2
    --99208233(+) AGCTGA/GGCATG 5 -- int10--------
    rs1827225371,2
    --99208317(+) AAGACC/TAGCCT 5 -- int10--------
    rs1440785921,2
    --99208335(+) ATTGCA/GAAACC 5 -- int10--------
    rs1866257371,2
    --99208352(+) CTACTA/TAAAAT 5 -- int10--------
    rs1465231071,2
    --99208386(+) GCAGGC/TGCCTG 5 -- int10--------
    rs79239131,2
    C,F,A--99208463(+) TGAGCC/TGAGAT 5 -- int13Minor allele frequency- T:0.50NA CSA 6
    rs1401073601,2
    C--99208484(+) ACTAC-/ATAGCCT 5 -- int10--------
    rs30660271,2
    C--99208485(+) CTACA-/TAGCCTG 5 -- int10--------
    rs728339701,2
    C,F--99208506(+) CGAGAG/CTTCAT 5 -- int13Minor allele frequency- C:0.50WA NA CSA 6

    HapMap Linkage Disequilibrium report for ZDHHC16 (99205927 - 99217127 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ZDHHC16: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZDHHC16 for disorders           About GeneDecksing

    2 diseases for ZDHHC16:    About MalaCards
    alzheimer's disease    malaria

    Human Genome Epidemiology (HuGE) Navigator: ZDHHC16 (1 document)

    Export disorders for ZDHHC16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZDHHC16 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZDHHC16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Aph2, a protein with a zf-DHHC motif, interacts with c-Abl and has pro-apoptotic activity. (PubMed id 12021275)1, 3, 9 Li B....Goff S.P. (2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    6. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
    7. Molecular cloning and characterization of human Aph2 gene, involved in AP-1 regulation by interaction with JAB1. (PubMed id 17123647)1 Zhang F....Gu J. (2006)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84287 HGNC: 20714 AceView: ZDHHC16 Ensembl:ENSG00000171307 euGenes: HUgn84287
    ECgene: ZDHHC16 H-InvDB: ZDHHC16

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZDHHC16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZDHHC16 gene:
    Search GeneIP for patents involving ZDHHC16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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