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Aliases for ZDHHC16 Gene

Aliases for ZDHHC16 Gene

  • Zinc Finger DHHC-Type Containing 16 2 3
  • Zinc Finger DHHC Domain-Containing Protein 16 3 4
  • Zinc Finger, DHHC-Type Containing 16 3 5
  • Abl-Philin 2 3 4
  • DHHC-16 3 4
  • APH2 3 4
  • Zinc Finger, DHHC Domain Containing 16 3
  • EC 2.3.1.225 4
  • EC 2.3.1 63

External Ids for ZDHHC16 Gene

Previous GeneCards Identifiers for ZDHHC16 Gene

  • GC10P098439
  • GC10P099337
  • GC10P098870
  • GC10P099195
  • GC10P092831

Summaries for ZDHHC16 Gene

GeneCards Summary for ZDHHC16 Gene

ZDHHC16 (Zinc Finger DHHC-Type Containing 16) is a Protein Coding gene. GO annotations related to this gene include protein-cysteine S-palmitoyltransferase activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC7.

UniProtKB/Swiss-Prot for ZDHHC16 Gene

  • May be involved in apoptosis regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC16 Gene

Genomics for ZDHHC16 Gene

Regulatory Elements for ZDHHC16 Gene

Promoters for ZDHHC16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZDHHC16 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZDHHC16 Gene

Chromosome:
10
Start:
97,446,131 bp from pter
End:
97,457,370 bp from pter
Size:
11,240 bases
Orientation:
Plus strand

Genomic View for ZDHHC16 Gene

Genes around ZDHHC16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC16 Gene

Proteins for ZDHHC16 Gene

  • Protein details for ZDHHC16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969W1-ZDH16_HUMAN
    Recommended name:
    Probable palmitoyltransferase ZDHHC16
    Protein Accession:
    Q969W1
    Secondary Accessions:
    • D3DR52
    • D3DR53
    • D3DR54
    • Q5JTG7
    • Q5JTH0
    • Q8N4Z6
    • Q8WY84
    • Q9BSV3

    Protein attributes for ZDHHC16 Gene

    Size:
    377 amino acids
    Molecular mass:
    43633 Da
    Quaternary structure:
    • Interacts with ABL1 (By similarity). Interacts with COPS5/JAB1 (PubMed:17123647).

    Alternative splice isoforms for ZDHHC16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZDHHC16 Gene

Proteomics data for ZDHHC16 Gene at MOPED

Post-translational modifications for ZDHHC16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ZDHHC16 Gene

Gene Families for ZDHHC16 Gene

Protein Domains for ZDHHC16 Gene

Graphical View of Domain Structure for InterPro Entry

Q969W1

UniProtKB/Swiss-Prot:

ZDH16_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
  • Contains 1 DHHC-type zinc finger.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family.
Similarity:
  • Contains 1 DHHC-type zinc finger.
genes like me logo Genes that share domains with ZDHHC16: view

Function for ZDHHC16 Gene

Molecular function for ZDHHC16 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
UniProtKB/Swiss-Prot Function:
May be involved in apoptosis regulation.

Enzyme Numbers (IUBMB) for ZDHHC16 Gene

genes like me logo Genes that share phenotypes with ZDHHC16: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC16 Gene

Localization for ZDHHC16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC16 Gene

Cytoplasm. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZDHHC16 Gene COMPARTMENTS Subcellular localization image for ZDHHC16 gene
Compartment Confidence
endoplasmic reticulum 3
plasma membrane 3
nucleus 2
golgi apparatus 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for ZDHHC16 Gene

Pathways & Interactions for ZDHHC16 Gene

SuperPathways for ZDHHC16 Gene

No Data Available

Interacting Proteins for ZDHHC16 Gene

Gene Ontology (GO) - Biological Process for ZDHHC16 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC16 Gene

Drugs & Compounds for ZDHHC16 Gene

(1) Drugs for ZDHHC16 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for ZDHHC16 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
genes like me logo Genes that share compounds with ZDHHC16: view

Transcripts for ZDHHC16 Gene

Unigene Clusters for ZDHHC16 Gene

Zinc finger, DHHC-type containing 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC16 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ·
SP1: - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - -
SP6: - -
SP7: - - - -
SP8: - -
SP9: - - - - -
SP10: - - -
SP11: -
SP12:

ExUns: 14c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for ZDHHC16 Gene

GeneLoc Exon Structure for
ZDHHC16
ECgene alternative splicing isoforms for
ZDHHC16

Expression for ZDHHC16 Gene

mRNA expression in normal human tissues for ZDHHC16 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZDHHC16 Gene



SOURCE GeneReport for Unigene cluster for ZDHHC16 Gene Hs.76662

mRNA Expression by UniProt/SwissProt for ZDHHC16 Gene

Q969W1-ZDH16_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with ZDHHC16: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for ZDHHC16 Gene

Orthologs for ZDHHC16 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC16 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZDHHC16 35
  • 93.02 (n)
  • 96.55 (a)
ZDHHC16 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZDHHC16 35
  • 93.72 (n)
  • 97.51 (a)
ZDHHC16 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zdhhc16 35
  • 92.06 (n)
  • 99.17 (a)
Zdhhc16 16
Zdhhc16 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC16 35
  • 99.65 (n)
  • 99.73 (a)
ZDHHC16 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zdhhc16 35
  • 91.32 (n)
  • 98.61 (a)
oppossum
(Monodelphis domestica)
Mammalia ZDHHC16 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 27 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ZDHHC16 35
  • 75.89 (n)
  • 73.78 (a)
ZDHHC16 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZDHHC16 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19094 35
zdhhc16 35
  • 67.25 (n)
  • 69.1 (a)
zebrafish
(Danio rerio)
Actinopterygii zdhhc16a 35
  • 59.56 (n)
  • 57.36 (a)
zgc63934 35
zdhhc16a 36
  • 51 (a)
OneToMany
zdhhc16b 36
  • 61 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004856 35
  • 49.64 (n)
  • 45.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5880 35
  • 52.09 (n)
  • 46.79 (a)
CG5880 36
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C43H6.7 35
  • 42.41 (n)
  • 33.8 (a)
dhhc-5 36
  • 25 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PFA3 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToOne
Species with no ortholog for ZDHHC16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC16 Gene

ENSEMBL:
Gene Tree for ZDHHC16 (if available)
TreeFam:
Gene Tree for ZDHHC16 (if available)

Paralogs for ZDHHC16 Gene

Paralogs for ZDHHC16 Gene

genes like me logo Genes that share paralogs with ZDHHC16: view

Variants for ZDHHC16 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC16 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs3066027 -- 97,448,728(+) CTACA(-/TA)GCCTG intron-variant
rs3818909 -- 97,456,196(+) AACCA(C/G)AAAGG intron-variant
rs4917770 -- 97,450,026(+) GCCAC(C/T)GCGCC intron-variant
rs5787241 -- 97,457,464(+) TTTTT(-/T)GGAGA downstream-variant-500B
rs5787242 -- 97,457,587(+) TTTTT(-/T)GAGAC downstream-variant-500B

Variation tolerance for ZDHHC16 Gene

Residual Variation Intolerance Score: 19.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZDHHC16 Gene

HapMap Linkage Disequilibrium report
ZDHHC16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZDHHC16 Gene

Disorders for ZDHHC16 Gene

Relevant External Links for ZDHHC16

Genetic Association Database (GAD)
ZDHHC16
Human Genome Epidemiology (HuGE) Navigator
ZDHHC16
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZDHHC16

No disorders were found for ZDHHC16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC16 Gene

Publications for ZDHHC16 Gene

  1. Aph2, a protein with a zf-DHHC motif, interacts with c-Abl and has pro-apoptotic activity. (PMID: 12021275) Li B. … Goff S.P. (J. Biol. Chem. 2002) 2 3 23 67
  2. Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system. (PMID: 23034182) Ohno Y. … Kihara A. (Mol. Biol. Cell 2012) 3
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3
  5. Molecular cloning and characterization of human Aph2 gene, involved in AP-1 regulation by interaction with JAB1. (PMID: 17123647) Zhang F. … Gu J. (Biochim. Biophys. Acta 2006) 3

Products for ZDHHC16 Gene

Sources for ZDHHC16 Gene

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