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Aliases for ZDHHC16 Gene

Aliases for ZDHHC16 Gene

  • Zinc Finger, DHHC-Type Containing 16 2 3
  • Zinc Finger DHHC Domain-Containing Protein 16 3 4
  • DHHC-16 3 4
  • Zinc Finger, DHHC Domain Containing 16 3
  • Probable Palmitoyltransferase ZDHHC16 3
  • Abl-Philin 2 3
  • EC 2.3.1.225 4
  • EC 2.3.1 63
  • APH2 3

External Ids for ZDHHC16 Gene

Summaries for ZDHHC16 Gene

GeneCards Summary for ZDHHC16 Gene

ZDHHC16 (Zinc Finger, DHHC-Type Containing 16) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring acyl groups. An important paralog of this gene is ZDHHC7.

UniProtKB/Swiss-Prot for ZDHHC16 Gene

  • May be involved in apoptosis regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC16 Gene

Genomics for ZDHHC16 Gene

Genomic Location for ZDHHC16 Gene

Start:
97,446,131 bp from pter
End:
97,457,370 bp from pter
Size:
11,240 bases
Orientation:
Plus strand

Genomic View for ZDHHC16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZDHHC16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC16 Gene

Regulatory Elements for ZDHHC16 Gene

Proteins for ZDHHC16 Gene

  • Protein details for ZDHHC16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969W1-ZDH16_HUMAN
    Recommended name:
    Probable palmitoyltransferase ZDHHC16
    Protein Accession:
    Q969W1
    Secondary Accessions:
    • D3DR52
    • D3DR53
    • D3DR54
    • Q5JTG7
    • Q5JTH0
    • Q8N4Z6
    • Q8WY84
    • Q9BSV3

    Protein attributes for ZDHHC16 Gene

    Size:
    377 amino acids
    Molecular mass:
    43633 Da
    Quaternary structure:
    • Interacts with ABL1.

    Alternative splice isoforms for ZDHHC16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZDHHC16 Gene

Proteomics data for ZDHHC16 Gene at MOPED

Post-translational modifications for ZDHHC16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for ZDHHC16 Gene

Gene Families for ZDHHC16 Gene

HGNC:
  • ZDHHC :Zinc fingers, DHHC-type

Protein Domains for ZDHHC16 Gene

Graphical View of Domain Structure for InterPro Entry

Q969W1

UniProtKB/Swiss-Prot:

ZDH16_HUMAN
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.:
    • Q969W1
Family:
  • Belongs to the DHHC palmitoyltransferase family.:
    • Q969W1
Similarity:
  • Contains 1 DHHC-type zinc finger.:
    • Q969W1
genes like me logo Genes that share domains with ZDHHC16: view

Function for ZDHHC16 Gene

Molecular function for ZDHHC16 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA
UniProtKB/Swiss-Prot Function: May be involved in apoptosis regulation.

Enzyme Numbers (IUBMB) for ZDHHC16 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016409 palmitoyltransferase activity IDA 23034182
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC16: view

Phenotypes for ZDHHC16 Gene

genes like me logo Genes that share phenotypes with ZDHHC16: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZDHHC16 Gene

Localization for ZDHHC16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC16 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZDHHC16 Gene COMPARTMENTS Subcellular localization image for ZDHHC16 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
golgi apparatus 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ZDHHC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC16: view

Pathways for ZDHHC16 Gene

SuperPathways for ZDHHC16 Gene

No Data Available

Interacting Proteins for ZDHHC16 Gene

Gene Ontology (GO) - Biological Process for ZDHHC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0008152 metabolic process --
GO:0018345 protein palmitoylation IDA 23034182
genes like me logo Genes that share ontologies with ZDHHC16: view

No data available for Pathways by source for ZDHHC16 Gene

Transcripts for ZDHHC16 Gene

Unigene Clusters for ZDHHC16 Gene

Zinc finger, DHHC-type containing 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC16 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ·
SP1: - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - -
SP6: - -
SP7: - - - -
SP8: - -
SP9: - - - - -
SP10: - - -
SP11: -
SP12:

ExUns: 14c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for ZDHHC16 Gene

GeneLoc Exon Structure for
ZDHHC16
ECgene alternative splicing isoforms for
ZDHHC16

Expression for ZDHHC16 Gene

mRNA expression in normal human tissues for ZDHHC16 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZDHHC16 Gene

SOURCE GeneReport for Unigene cluster for ZDHHC16 Gene Hs.76662

genes like me logo Genes that share expressions with ZDHHC16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZDHHC16 Gene

Orthologs for ZDHHC16 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC16 35
  • 99.65 (n)
  • 99.73 (a)
ZDHHC16 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZDHHC16 35
  • 93.02 (n)
  • 96.55 (a)
ZDHHC16 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZDHHC16 35
  • 93.72 (n)
  • 97.51 (a)
ZDHHC16 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zdhhc16 35
  • 92.06 (n)
  • 99.17 (a)
Zdhhc16 16
Zdhhc16 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZDHHC16 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 27 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Zdhhc16 35
  • 91.32 (n)
  • 98.61 (a)
chicken
(Gallus gallus)
Aves ZDHHC16 35
  • 75.89 (n)
  • 73.78 (a)
ZDHHC16 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZDHHC16 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19094 35
zdhhc16 35
  • 67.25 (n)
  • 69.1 (a)
zebrafish
(Danio rerio)
Actinopterygii zdhhc16a 35
  • 59.56 (n)
  • 57.36 (a)
zdhhc16a 36
  • 51 (a)
OneToMany
zdhhc16b 36
  • 61 (a)
OneToMany
zgc63934 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004856 35
  • 49.64 (n)
  • 45.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5880 35
  • 52.09 (n)
  • 46.79 (a)
CG5880 36
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C43H6.7 35
  • 42.41 (n)
  • 33.8 (a)
dhhc-5 36
  • 25 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PFA3 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToOne
Species with no ortholog for ZDHHC16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC16 Gene

ENSEMBL:
Gene Tree for ZDHHC16 (if available)
TreeFam:
Gene Tree for ZDHHC16 (if available)

Paralogs for ZDHHC16 Gene

Paralogs for ZDHHC16 Gene

genes like me logo Genes that share paralogs with ZDHHC16: view

Variants for ZDHHC16 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC16 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs3066027 -- 97,448,728(+) CTACA(-/TA)GCCTG intron-variant
rs3818909 -- 97,456,196(+) AACCA(C/G)AAAGG intron-variant
rs4917770 -- 97,450,026(+) GCCAC(C/T)GCGCC intron-variant
rs5787241 -- 97,457,464(+) TTTTT(-/T)GGAGA downstream-variant-500B
rs5787242 -- 97,457,587(+) TTTTT(-/T)GAGAC downstream-variant-500B

Relevant External Links for ZDHHC16 Gene

HapMap Linkage Disequilibrium report
ZDHHC16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZDHHC16 Gene

Disorders for ZDHHC16 Gene

Relevant External Links for ZDHHC16

Genetic Association Database (GAD)
ZDHHC16
Human Genome Epidemiology (HuGE) Navigator
ZDHHC16
genes like me logo Genes that share disorders with ZDHHC16: view

No data available for UniProtKB/Swiss-Prot for ZDHHC16 Gene

Publications for ZDHHC16 Gene

  1. Aph2, a protein with a zf-DHHC motif, interacts with c-Abl and has pro-apoptotic activity. (PMID: 12021275) Li B. … Goff S.P. (J. Biol. Chem. 2002) 2 3 23
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48

Products for ZDHHC16 Gene

  • antibodies-online peptides for ZDHHC16
  • antibodies-online antibodies for ZDHHC16
  • antibodies-online kits for ZDHHC16

Sources for ZDHHC16 Gene

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