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Aliases for ZDHHC15 Gene

Aliases for ZDHHC15 Gene

  • Zinc Finger DHHC-Type Containing 15 2 3 5
  • Zinc Finger DHHC Domain-Containing Protein 15 3 4
  • DHHC-15 3 4
  • Zinc Finger, DHHC Domain Containing 15 3
  • Palmitoyltransferase ZDHHC15 3
  • EC 4
  • EC 2.3.1 61
  • MRX91 3

External Ids for ZDHHC15 Gene

Previous GeneCards Identifiers for ZDHHC15 Gene

  • GC0XM071766
  • GC0XM072806
  • GC0XM073458
  • GC0XM073459
  • GC0XM074375
  • GC0XM074504
  • GC0XM074588
  • GC0XM068222

Summaries for ZDHHC15 Gene

Entrez Gene Summary for ZDHHC15 Gene

  • The protein encoded by this gene belongs to the DHHC palmitoyltransferase family. Mutations in this gene are associated with mental retardatio X-linked type 91 (MRX91). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for ZDHHC15 Gene

ZDHHC15 (Zinc Finger DHHC-Type Containing 15) is a Protein Coding gene. GO annotations related to this gene include receptor activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC2.

UniProtKB/Swiss-Prot for ZDHHC15 Gene

  • Palmitoyltransferase specific for GAP43 and DLG4/PSD95.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC15 Gene

Genomics for ZDHHC15 Gene

Regulatory Elements for ZDHHC15 Gene

Enhancers for ZDHHC15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF076142 0.8 Ensembl ENCODE 14.4 -624.0 -623975 10.0 DRAP1 ATF1 PKNOX1 ZNF146 ZNF223 MAX ZNF384 ZBTB40 HIC1 ZNF366 ZDHHC15 TTC3P1 PBDC1 ABCB7 ENSG00000232186 MAGEE1 PIR52738 GC0XP076095
GH0XF075522 0.9 ENCODE 8.7 +0.4 427 2.0 HCFC1 POLR2A NBN MLLT1 EBF1 NR2C2 ZDHHC15 UPRT PIR41146
GH0XF076171 0.2 ENCODE 7.5 -649.6 -649644 3.1 TBP PKNOX1 NFRKB SIN3A DMAP1 ZSCAN9 RARA YY1 GLIS2 EGR1 ZDHHC15 PBDC1 LOC100216356
GH0XF076427 0.4 ENCODE 5.9 -904.2 -904232 1.6 ZFHX2 SAP130 POLR2A NRF1 PRDM10 ZNF48 EGR2 ZDHHC15 TTC3P1 GC0XP076431 MAGEE1
GH0XF075278 0.9 Ensembl ENCODE 5.7 +244.6 244550 1.3 GATA3 ZDHHC15 UPRT GC0XP075324
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZDHHC15 on UCSC Golden Path with GeneCards custom track

Promoters for ZDHHC15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000160979 425 1999 HCFC1 POLR2A NBN MLLT1 EBF1 NR2C2

Genomic Location for ZDHHC15 Gene

75,368,427 bp from pter
75,523,626 bp from pter
155,200 bases
Minus strand

Genomic View for ZDHHC15 Gene

Genes around ZDHHC15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC15 Gene

Proteins for ZDHHC15 Gene

  • Protein details for ZDHHC15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Palmitoyltransferase ZDHHC15
    Protein Accession:
    Secondary Accessions:
    • B3KVG7
    • Q3SY30
    • Q6UWH3

    Protein attributes for ZDHHC15 Gene

    337 amino acids
    Molecular mass:
    39331 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZDHHC15 Gene


neXtProt entry for ZDHHC15 Gene

Selected DME Specific Peptides for ZDHHC15 Gene


Post-translational modifications for ZDHHC15 Gene

Other Protein References for ZDHHC15 Gene

Domains & Families for ZDHHC15 Gene

Gene Families for ZDHHC15 Gene

Protein Domains for ZDHHC15 Gene

Graphical View of Domain Structure for InterPro Entry



  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
  • The DHHC domain is required for palmitoyltransferase activity.
  • Contains 1 DHHC domain.
  • Belongs to the DHHC palmitoyltransferase family.
genes like me logo Genes that share domains with ZDHHC15: view

Function for ZDHHC15 Gene

Molecular function for ZDHHC15 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
UniProtKB/Swiss-Prot Function:
Palmitoyltransferase specific for GAP43 and DLG4/PSD95.

Enzyme Numbers (IUBMB) for ZDHHC15 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016409 palmitoyltransferase activity IDA 23034182
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC15: view
genes like me logo Genes that share phenotypes with ZDHHC15: view

Human Phenotype Ontology for ZDHHC15 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for ZDHHC15

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC15 Gene

Localization for ZDHHC15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC15 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ZDHHC15 Gene COMPARTMENTS Subcellular localization image for ZDHHC15 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 3
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for ZDHHC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IDA 16647879
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with ZDHHC15: view

Pathways & Interactions for ZDHHC15 Gene

SuperPathways for ZDHHC15 Gene

No Data Available

Interacting Proteins for ZDHHC15 Gene

Gene Ontology (GO) - Biological Process for ZDHHC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016188 synaptic vesicle maturation IBA --
GO:0018345 protein palmitoylation IDA 23034182
GO:0045184 establishment of protein localization IEA --
genes like me logo Genes that share ontologies with ZDHHC15: view

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC15 Gene

Drugs & Compounds for ZDHHC15 Gene

(1) Drugs for ZDHHC15 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for ZDHHC15 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZDHHC15: view

Transcripts for ZDHHC15 Gene

Unigene Clusters for ZDHHC15 Gene

Zinc finger, DHHC-type containing 15:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC15 Gene

No ASD Table

Relevant External Links for ZDHHC15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZDHHC15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZDHHC15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZDHHC15 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZDHHC15 Gene

Protein tissue co-expression partners for ZDHHC15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZDHHC15 Gene:


SOURCE GeneReport for Unigene cluster for ZDHHC15 Gene:


mRNA Expression by UniProt/SwissProt for ZDHHC15 Gene:

Tissue specificity: Expressed in placenta, liver, lung, kidney, heart and brain.
genes like me logo Genes that share expression patterns with ZDHHC15: view

Primer Products

No data available for mRNA differential expression in normal tissues for ZDHHC15 Gene

Orthologs for ZDHHC15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZDHHC15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZDHHC15 34 35
  • 97.69 (n)
(Canis familiaris)
Mammalia ZDHHC15 34 35
  • 94.3 (n)
(Bos Taurus)
Mammalia ZDHHC15 34 35
  • 94.07 (n)
(Mus musculus)
Mammalia Zdhhc15 34 16 35
  • 93.77 (n)
(Rattus norvegicus)
Mammalia Zdhhc15 34
  • 93.77 (n)
(Monodelphis domestica)
Mammalia ZDHHC15 35
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia ZDHHC15 35
  • 64 (a)
(Gallus gallus)
Aves ZDHHC15 34 35
  • 74.92 (n)
(Anolis carolinensis)
Reptilia ZDHHC15 35
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc15 34
  • 69.25 (n)
(Danio rerio)
Actinopterygii zdhhc15b 34 35
  • 66.26 (n)
wufc02b12 34
fruit fly
(Drosophila melanogaster)
Insecta CG1407 35
  • 33 (a)
CG17287 35
  • 33 (a)
(Caenorhabditis elegans)
Secernentea dhhc-4 35
  • 30 (a)
spe-10 35
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PFA3 35 37
  • 24 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G60800 34
  • 49.65 (n)
(Oryza sativa)
Liliopsida Os03g0804300 34
  • 48.9 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pfa3 34
  • 46.39 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01267 34
  • 42.59 (n)
Species where no ortholog for ZDHHC15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC15 Gene

Gene Tree for ZDHHC15 (if available)
Gene Tree for ZDHHC15 (if available)

Paralogs for ZDHHC15 Gene

Paralogs for ZDHHC15 Gene

(2) SIMAP similar genes for ZDHHC15 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZDHHC15: view

Variants for ZDHHC15 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC15 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs144128364 Uncertain significance 75,379,158(+) TATGT(C/T)TCCGT nc-transcript-variant, reference, synonymous-codon
rs199537523 Uncertain significance 75,478,992(+) GAAAT(-/A/AA)AAAAA intron-variant
rs797046116 Uncertain significance 75,523,015(-) GGCGA(A/G)GCTGG nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs145401990 Benign 75,421,896(+) TTCTT(A/C/G)TTATC nc-transcript-variant, reference, missense
rs147278537 Benign 75,421,980(+) GGAGT(A/G)CAGAA nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC15 Gene

Variant ID Type Subtype PubMed ID
esv1585432 CNV deletion 17803354
esv25282 CNV gain 19812545
esv2740234 CNV deletion 23290073
esv2740235 CNV deletion 23290073
esv2740236 CNV deletion 23290073
esv2740237 CNV deletion 23290073
esv3239932 CNV deletion 24192839
esv988916 CNV deletion 20482838
nsv1115270 CNV deletion 24896259
nsv425323 CNV deletion 16902084

Variation tolerance for ZDHHC15 Gene

Residual Variation Intolerance Score: 42.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 16.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZDHHC15 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC15 Gene

Disorders for ZDHHC15 Gene


  • Mental retardation, X-linked 91 (MRX91) [MIM:300577]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. {ECO:0000269 PubMed:15915161}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Relevant External Links for ZDHHC15

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZDHHC15 Gene.

No data available for MalaCards and Genatlas for ZDHHC15 Gene

Publications for ZDHHC15 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  2. Loss of ZDHHC15 expression in a woman with a balanced translocation t(X;15)(q13.3;cen) and severe mental retardation. (PMID: 15915161) Mansouri M.R. … Dahl N. (Eur. J. Hum. Genet. 2005) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for ZDHHC15 Gene

Sources for ZDHHC15 Gene

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