ZDHHC15 Gene
protein-coding GIFtS: 47
GCID: GC0XM074588
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|
zinc finger, DHHC-type containing 15
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Aliases
for ZDHHC15 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger, DHHC-Type Containing 151 2 | | Palmitoyltransferase ZDHHC152 | | MRX911 2 5 | | Zinc Finger, DHHC Domain Containing 152 | | Zinc Finger DHHC Domain-Containing Protein 152 3 | | EC 2.3.1.-3 | | DHHC-152 3 | | EC 2.3.18 | | FLJ318121 | | |
Export aliases for ZDHHC15 gene to outside databasesPrevious GC identifers: GC0XM071766 GC0XM072806 GC0XM073458 GC0XM073459 GC0XM074375 GC0XM074504 GC0XM068222 |
Summaries
for ZDHHC15 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZDHHC15:
The protein encoded by this gene belongs to the DHHC palmitoyltransferase family. Mutations in this gene are associatedwith mental retardatio X-linked type 91 (MRX91). Alternatively spliced transcript variants encoding different isoformshave been found for this gene. (provided by RefSeq, Sep 2009)
UniProtKB/Swiss-Prot: ZDH15_HUMAN, Q96MV8Function: Palmitoyltransferase specific for GAP43 and DLG4/PSD95 (By similarity)
|
Genomic Views
for ZDHHC15 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011669.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZDHHC15 gene promoter:
POU2F2 (Oct-2.1) Oct-B1 oct-B3 oct-B2 POU2F2 POU2F2C POU2F1 POU2F1a POU2F2B MRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZDHHC15
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZDHHC15 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq13.3 Ensembl cytogenetic band: Xq13.3 HGNC cytogenetic band: Xq13.3ZDHHC15 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM074588: view genomic region
(about GC identifiers)
Start:
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74,588,262 bp from pter |
End:
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74,743,337 bp from pter |
Size:
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155,076 bases |
Orientation:
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minus strand |
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Proteins
for ZDHHC15 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZDH15_HUMAN, Q96MV8 (See
protein sequence)Recommended Name: Palmitoyltransferase ZDHHC15 Size: 337 amino acids; 39331 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B3KVG7 Q3SY30 Q6UWH3Alternative splicing: 3 isoforms: Q96MV8-1 Q96MV8-2 Q96MV8-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZDHHC15: NX_Q96MV8
Post-translational modifications:
Autopalmitoylated (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96MV8
4/6 DME Specific Peptides for ZDHHC15 (Q96MV8) (see all 6)
ZDHHC15 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001139728.1 NP_001139729.1 NP_659406.1
ENSEMBL proteins: ENSP00000362465 ENSP00000445420 ENSP00000362459
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
ZDHHC15 for ontologies About GeneDecksing
ZDHHC15 Antibody Products:
Assay Products for ZDHHC15: |
Protein
Domains /
Families
for ZDHHC15 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZDHHC15 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96MV8ProtoNet protein and cluster: Q96MV8 1 Blocks protein family: IPB001594 Zn-finger
UniProtKB/Swiss-Prot: ZDH15_HUMAN, Q96MV8Domain: The DHHC domain is required for palmitoyltransferase activitySimilarity: Belongs to the DHHC palmitoyltransferase familySimilarity: Contains 1 DHHC-type zinc finger |
Function
for ZDHHC15 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZDH15_HUMAN, Q96MV8Function: Palmitoyltransferase specific for GAP43 and DLG4/PSD95 (By similarity)Catalytic activity: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoAEnzyme Numbers (IUBMB): EC 2.3.12 EC 2.3.1.-1
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC15 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- | | GO:0016409 | palmitoyltransferase activity |
IEA | -- | | GO:0016740 | transferase activity |
-- | -- |
ZDHHC15 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZDHHC15:
Animal Models:
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Zdhhc15):
ZDHHC15 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ZDHHC15 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZDHHC15
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5/11 Interacting proteins for ZDHHC15 (Q96MV83 ENSP000003624654) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016188 | synaptic vesicle maturation |
IEA | -- | | GO:0018345 | protein palmitoylation |
IEA | -- | | GO:0045184 | establishment of protein localization |
IEA | -- |
ZDHHC15 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZDHHC15 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZDHHC15
Search CenterWatch for drugs/clinical trials and news about ZDHHC15 / ZDH15
|
Transcripts
for ZDHHC15 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZDHHC15 gene (3 alternative transcripts): NM_001146256.1 NM_001146257.1 NM_144969.2 Unigene Cluster for ZDHHC15: Zinc finger, DHHC-type containing 15 Hs.253211 [show with all ESTs]Unigene Representative Sequence: NM_1449694 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000373367 ENST00000482827 ENST00000541184(uc004ecg.3 uc004ech.3 uc011mqo.1 uc004eci.2)
ENST00000373361
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC15 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC15 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): ZDHHC15 (NM_144969) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZDHHC15 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZDHHC15 |
Additional cDNA sequence: AK056374.1 AK122885.1 AK123754.1 AK128587.1 AY358786.1 BC103980.1 BC103981.1 BC103982.1 4 DOTS entries: DT.102839780 DT.40261152 DT.75109446 DT.121323721 24/32 AceView cDNA sequences (see all 32): AY358786 BU102099 AL134778 BX280612 AI469998 BQ028106 AK128587 NM_144969 BX955930 AK056374 CD637242 AK123754 AA424051 AI628380 CD637246 AK122885 BX441758 CD637244 AA421824 CD637238 AI362114 CD637240 N63207 AW104616
GeneLoc Exon Structure
|
Expression
for ZDHHC15 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZDHHC15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ZDHHC15 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZDHHC15
SOURCE GeneReport for Unigene cluster: Hs.253211
UniProtKB/Swiss-Prot: ZDH15_HUMAN, Q96MV8Tissue specificity: Expressed in placenta, liver, lung, kidney, heart and brain
SABiosciences Custom PCR Arrays for ZDHHC15
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZDHHC15
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC15 |
Orthologs
for ZDHHC15 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ZDHHC15 gene from 7/29 species (see all 29) About this table
ENSEMBL Gene Tree for ZDHHC15 (if available)
TreeFam Gene Tree for ZDHHC15 (if available) |
Paralogs
for ZDHHC15 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZDHHC15 gene
- ZDHHC212 ZDHHC32 ZDHHC72 ZDHHC202 ZDHHC232 ZDHHC22
2 SIMAP similar genes for ZDHHC15 using alignment to 2 protein entries: ZDH15_HUMAN (see all proteins):ZDHHC2 ZDHHC20
ZDHHC15 for paralogs About GeneDecksing
|
Genomic Variants
for ZDHHC15 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZDHHC15 (74588262 - 74743337 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZDHHC15
1 CNV: 74012 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZDHHC15 |
|
Disorders
/ Diseases
for ZDHHC15 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZDHHC15 for disorders About GeneDecksing
OMIM gene information: 300576
OMIM disorders: 300577
UniProtKB/Swiss-Prot: ZDH15_HUMAN, Q96MV8
Defects in ZDHHC15 are the cause of mental retardation X-linked type 91 (MRX91) [MIM:300577]. Mentalretardation is characterized by significantly sub-average general intellectual functioning associated with impairmentsin adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients donot manifest other clinical signs
5  diseases for ZDHHC15: About MalaCardsmental retardation, x-linked neuronal ceroid-lipofuscinosis ceroid lipofuscinosis malaria
neuronitis
Export disorders for ZDHHC15 gene to outside databases
|
Publications
for ZDHHC15 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZDHHC15 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZDHHC15) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- Loss of ZDHHC15 expression in a woman with a balanced translocation t(X;15)(q13.3;cen) and severe mental retardation. (PubMed id 15915161)1, 2 Mansouri M.R.... Dahl N. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZDHHC15 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZDHHC15 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZDHHC15 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZDHHC15 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZDHHC15 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZDHHC15 gene:
Search GeneIP for patents involving ZDHHC15
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZDHHC15 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC15 |
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