Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZDHHC14 Gene

Aliases for ZDHHC14 Gene

  • Zinc Finger DHHC-Type Containing 14 2 3
  • Zinc Finger DHHC Domain-Containing Protein 14 3 4
  • Zinc Finger, DHHC-Type Containing 14 3 5
  • NEW1 Domain-Containing Protein 3 4
  • DHHC-14 3 4
  • NEW1CP 3 4
  • Zinc Finger, DHHC Domain Containing 14 3
  • NEW1 Domain Containing Protein 3
  • EC 2.3.1.225 4
  • EC 2.3.1 63

External Ids for ZDHHC14 Gene

Previous GeneCards Identifiers for ZDHHC14 Gene

  • GC06P157676
  • GC06P157711
  • GC06P157772
  • GC06P155266

Summaries for ZDHHC14 Gene

GeneCards Summary for ZDHHC14 Gene

ZDHHC14 (Zinc Finger DHHC-Type Containing 14) is a Protein Coding gene. Diseases associated with ZDHHC14 include chromosome 6q24-q25 deletion syndrome. GO annotations related to this gene include protein-cysteine S-palmitoyltransferase activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC18.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC14 Gene

Genomics for ZDHHC14 Gene

Regulatory Elements for ZDHHC14 Gene

Promoters for ZDHHC14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZDHHC14 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZDHHC14 Gene

Chromosome:
6
Start:
157,381,133 bp from pter
End:
157,678,146 bp from pter
Size:
297,014 bases
Orientation:
Plus strand

Genomic View for ZDHHC14 Gene

Genes around ZDHHC14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC14 Gene

Proteins for ZDHHC14 Gene

  • Protein details for ZDHHC14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZN3-ZDH14_HUMAN
    Recommended name:
    Probable palmitoyltransferase ZDHHC14
    Protein Accession:
    Q8IZN3
    Secondary Accessions:
    • A6NDB7
    • Q5JS07
    • Q5JS08
    • Q6PHS4
    • Q8IZN2
    • Q9H7F1

    Protein attributes for ZDHHC14 Gene

    Size:
    488 amino acids
    Molecular mass:
    53388 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14941.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZDHHC14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZDHHC14 Gene

Proteomics data for ZDHHC14 Gene at MOPED

Post-translational modifications for ZDHHC14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZDHHC14 Gene

Domains & Families for ZDHHC14 Gene

Gene Families for ZDHHC14 Gene

Protein Domains for ZDHHC14 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IZN3

UniProtKB/Swiss-Prot:

ZDH14_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
  • Contains 1 DHHC-type zinc finger.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
Similarity:
  • Contains 1 DHHC-type zinc finger.
genes like me logo Genes that share domains with ZDHHC14: view

Function for ZDHHC14 Gene

Molecular function for ZDHHC14 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Enzyme Numbers (IUBMB) for ZDHHC14 Gene

Phenotypes for ZDHHC14 Gene

GenomeRNAi human phenotypes for ZDHHC14:
genes like me logo Genes that share phenotypes with ZDHHC14: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ZDHHC14

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC14 Gene

Localization for ZDHHC14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC14 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZDHHC14 Gene COMPARTMENTS Subcellular localization image for ZDHHC14 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
cytosol 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ZDHHC14 Gene

Pathways & Interactions for ZDHHC14 Gene

SuperPathways for ZDHHC14 Gene

No Data Available

Interacting Proteins for ZDHHC14 Gene

Gene Ontology (GO) - Biological Process for ZDHHC14 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC14 Gene

Drugs & Compounds for ZDHHC14 Gene

(1) Drugs for ZDHHC14 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for ZDHHC14 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
genes like me logo Genes that share compounds with ZDHHC14: view

Transcripts for ZDHHC14 Gene

Unigene Clusters for ZDHHC14 Gene

Zinc finger, DHHC-type containing 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC14 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - - -
SP2: - - - -
SP3:
SP4: - -
SP5: -

Relevant External Links for ZDHHC14 Gene

GeneLoc Exon Structure for
ZDHHC14
ECgene alternative splicing isoforms for
ZDHHC14

Expression for ZDHHC14 Gene

mRNA expression in normal human tissues for ZDHHC14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZDHHC14 Gene

This gene is overexpressed in Breast (62.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZDHHC14 Gene



SOURCE GeneReport for Unigene cluster for ZDHHC14 Gene Hs.745003

genes like me logo Genes that share expression patterns with ZDHHC14: view

Protein tissue co-expression partners for ZDHHC14 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZDHHC14 Gene

Orthologs for ZDHHC14 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZDHHC14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZDHHC14 35
  • 92.88 (n)
  • 96.92 (a)
ZDHHC14 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZDHHC14 35
  • 92.27 (n)
  • 96.71 (a)
ZDHHC14 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zdhhc14 35
  • 90.1 (n)
  • 95.08 (a)
Zdhhc14 16
Zdhhc14 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC14 35
  • 99.43 (n)
  • 100 (a)
ZDHHC14 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zdhhc14 35
  • 89.75 (n)
  • 95.49 (a)
oppossum
(Monodelphis domestica)
Mammalia ZDHHC14 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC14 36
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZDHHC14 35
  • 81.15 (n)
  • 90.37 (a)
ZDHHC14 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZDHHC14 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc14 35
  • 76.04 (n)
  • 84.58 (a)
zebrafish
(Danio rerio)
Actinopterygii zdhhc14 35
  • 69.19 (n)
  • 71.64 (a)
zdhhc14 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta app 35
  • 64.48 (n)
  • 66.44 (a)
app 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dhhc-2 35
  • 51.91 (n)
  • 44.59 (a)
dhhc-2 36
  • 35 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G26935 35
  • 51.4 (n)
  • 42.66 (a)
rice
(Oryza sativa)
Liliopsida Os01g0925300 35
  • 52.86 (n)
  • 42.97 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.6808 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3762 36
  • 54 (a)
OneToMany
Species with no ortholog for ZDHHC14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ZDHHC14 Gene

ENSEMBL:
Gene Tree for ZDHHC14 (if available)
TreeFam:
Gene Tree for ZDHHC14 (if available)

Paralogs for ZDHHC14 Gene

Paralogs for ZDHHC14 Gene

(5) SIMAP similar genes for ZDHHC14 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZDHHC14: view

Variants for ZDHHC14 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC14 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs8180688 - 157,653,560(+) CGACA(C/T)GCCGC reference, missense
rs181335 -- 157,475,965(-) cttcc(C/G)tctta intron-variant
rs183048 -- 157,471,821(-) CTTCA(C/T)AGAGG intron-variant
rs65641 -- 157,494,294(+) GGAGA(C/T)CAGCC intron-variant
rs241577 -- 157,476,303(-) tctag(G/T)ttatc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC14 Gene

Variant ID Type Subtype PubMed ID
esv33003 CNV Loss 17666407
esv2660140 CNV Deletion 23128226
nsv886795 CNV Loss 21882294
esv28761 CNV Gain 19812545
esv2124670 CNV Deletion 18987734
esv2732980 CNV Deletion 23290073
nsv509156 CNV Insertion 20534489
esv2610603 CNV Deletion 19546169
esv2076685 CNV Deletion 18987734
esv3496 CNV Deletion 18987735
esv1113682 CNV Deletion 17803354
esv2732981 CNV Deletion 23290073
esv996138 CNV Deletion 20482838
esv6974 CNV Loss 19470904
esv273971 CNV Insertion 20981092
esv270746 CNV Insertion 20981092
esv274649 CNV Insertion 20981092
esv33442 CNV Loss 17666407
esv33371 CNV Loss 17666407
esv2732982 CNV Deletion 23290073

Variation tolerance for ZDHHC14 Gene

Residual Variation Intolerance Score: 38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.69; 32.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZDHHC14 Gene

HapMap Linkage Disequilibrium report
ZDHHC14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC14 Gene

Disorders for ZDHHC14 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZDHHC14 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 6q24-q25 deletion syndrome
  • 6q25 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZDHHC14

Genetic Association Database (GAD)
ZDHHC14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZDHHC14
genes like me logo Genes that share disorders with ZDHHC14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZDHHC14 Gene

Publications for ZDHHC14 Gene

  1. Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D. (PMID: 22041458) Clark S.L. … van den Oord E.J. (Psychol Med 2012) 3 48 67
  2. Identification of ZDHHC14 as a novel human tumour suppressor gene. (PMID: 24407904) Yeste-Velasco M. … Lu Y.J. (J. Pathol. 2014) 3
  3. Overexpression of ZDHHC14 promotes migration and invasion of scirrhous type gastric cancer. (PMID: 24807047) Oo H.Z. … Yasui W. (Oncol. Rep. 2014) 3
  4. Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system. (PMID: 23034182) Ohno Y. … Kihara A. (Mol. Biol. Cell 2012) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for ZDHHC14 Gene

Sources for ZDHHC14 Gene

Back to Top

Content