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Aliases for ZDHHC14 Gene

Aliases for ZDHHC14 Gene

  • Zinc Finger DHHC-Type Containing 14 2 3 5
  • Zinc Finger DHHC Domain-Containing Protein 14 3 4
  • NEW1 Domain-Containing Protein 3 4
  • DHHC-14 3 4
  • NEW1CP 3 4
  • Zinc Finger, DHHC Domain Containing 14 3
  • Probable Palmitoyltransferase ZDHHC14 3
  • EC 2.3.1.225 4
  • EC 2.3.1 61

External Ids for ZDHHC14 Gene

Previous GeneCards Identifiers for ZDHHC14 Gene

  • GC06P157676
  • GC06P157711
  • GC06P157772
  • GC06P155266

Summaries for ZDHHC14 Gene

GeneCards Summary for ZDHHC14 Gene

ZDHHC14 (Zinc Finger DHHC-Type Containing 14) is a Protein Coding gene. Diseases associated with ZDHHC14 include Chromosome 6Q24-Q25 Deletion Syndrome. GO annotations related to this gene include protein-cysteine S-palmitoyltransferase activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC18.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC14 Gene

Genomics for ZDHHC14 Gene

Regulatory Elements for ZDHHC14 Gene

Enhancers for ZDHHC14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G157460 1.6 FANTOM5 Ensembl ENCODE 15 +80.4 80447 2.7 HDGF PKNOX1 FOXA2 ATF1 YBX1 TCF12 ZNF121 ZNF766 CBX5 GATA2 ZDHHC14 SNX9 GC06P157400 GC06P157399 MIR3692
GH06G157518 1.4 Ensembl ENCODE dbSUPER 11.3 +137.6 137634 1.0 ATF1 FOXA2 ARNT SIN3A ZNF766 ZMIZ1 KLF13 REST ZNF592 MEF2D ZDHHC14 MIR3692 GC06P157400 GC06P157399
GH06G157438 1.1 Ensembl ENCODE 11.4 +57.6 57613 1.1 FOXA2 SAP130 ZNF175 CEBPG FEZF1 ZBTB40 RAD21 CHAMP1 ZNF316 FOXK2 ZDHHC14 GC06P157400 GC06P157399 MIR3692
GH06G157517 1.1 ENCODE dbSUPER 11.3 +136.7 136688 0.6 ELF3 FOXA2 MLX ARID4B RAD21 RARA GATA4 CREM SP5 ZHX2 ZDHHC14 MIR3692 GC06P157400 GC06P157399
GH06G157464 1.1 Ensembl ENCODE 11.2 +84.1 84098 1.3 HDGF TBL1XR1 BMI1 YBX1 ZBTB40 YY1 RELB ETV6 IKZF2 CREM ZDHHC14 MIR3692 GC06P157400 GC06P157399
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZDHHC14 on UCSC Golden Path with GeneCards custom track

Promoters for ZDHHC14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000205885 167 3001 HDGF FOXA2 MLX ARNT CREB3L1 AGO1 ZFP64 ARID4B SIN3A FEZF1

Genomic Location for ZDHHC14 Gene

Chromosome:
6
Start:
157,381,133 bp from pter
End:
157,678,146 bp from pter
Size:
297,014 bases
Orientation:
Plus strand

Genomic View for ZDHHC14 Gene

Genes around ZDHHC14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC14 Gene

Proteins for ZDHHC14 Gene

  • Protein details for ZDHHC14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZN3-ZDH14_HUMAN
    Recommended name:
    Probable palmitoyltransferase ZDHHC14
    Protein Accession:
    Q8IZN3
    Secondary Accessions:
    • A6NDB7
    • Q5JS07
    • Q5JS08
    • Q6PHS4
    • Q8IZN2
    • Q9H7F1

    Protein attributes for ZDHHC14 Gene

    Size:
    488 amino acids
    Molecular mass:
    53388 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14941.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZDHHC14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZDHHC14 Gene

Selected DME Specific Peptides for ZDHHC14 Gene

Q8IZN3:
  • TTNEDIKGSW
  • NCVERFDHHCPW
  • TLLRTSFSDPGV
  • YRPPPRT
  • FDCPYLA
  • RFDHHCPWVG
  • RPPRASHCS
  • RRKWEVFPGRN
  • ILFFFVM

Post-translational modifications for ZDHHC14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ZDHHC14 Gene

Gene Families for ZDHHC14 Gene

Protein Domains for ZDHHC14 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IZN3

UniProtKB/Swiss-Prot:

ZDH14_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
genes like me logo Genes that share domains with ZDHHC14: view

Function for ZDHHC14 Gene

Molecular function for ZDHHC14 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Enzyme Numbers (IUBMB) for ZDHHC14 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016409 palmitoyltransferase activity IDA 23034182
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC14: view

Phenotypes for ZDHHC14 Gene

GenomeRNAi human phenotypes for ZDHHC14:
genes like me logo Genes that share phenotypes with ZDHHC14: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ZDHHC14

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC14 Gene

Localization for ZDHHC14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC14 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC14 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ZDHHC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 16647879
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC14: view

Pathways & Interactions for ZDHHC14 Gene

SuperPathways for ZDHHC14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018345 protein palmitoylation IDA 23034182
genes like me logo Genes that share ontologies with ZDHHC14: view

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC14 Gene

Drugs & Compounds for ZDHHC14 Gene

(1) Drugs for ZDHHC14 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for ZDHHC14 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
genes like me logo Genes that share compounds with ZDHHC14: view

Transcripts for ZDHHC14 Gene

mRNA/cDNA for ZDHHC14 Gene

Unigene Clusters for ZDHHC14 Gene

Zinc finger, DHHC-type containing 14:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC14 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - - -
SP2: - - - -
SP3:
SP4: - -
SP5: -

Relevant External Links for ZDHHC14 Gene

GeneLoc Exon Structure for
ZDHHC14
ECgene alternative splicing isoforms for
ZDHHC14

Expression for ZDHHC14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZDHHC14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZDHHC14 Gene

This gene is overexpressed in Breast (62.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZDHHC14 Gene



Protein tissue co-expression partners for ZDHHC14 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZDHHC14 Gene:

ZDHHC14

SOURCE GeneReport for Unigene cluster for ZDHHC14 Gene:

Hs.745003

Evidence on tissue expression from TISSUES for ZDHHC14 Gene

  • Stomach(4.3)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZDHHC14: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC14 Gene

Orthologs for ZDHHC14 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZDHHC14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC14 34 35
  • 99.43 (n)
cow
(Bos Taurus)
Mammalia ZDHHC14 34 35
  • 92.88 (n)
dog
(Canis familiaris)
Mammalia ZDHHC14 34 35
  • 92.27 (n)
mouse
(Mus musculus)
Mammalia Zdhhc14 34 16 35
  • 90.1 (n)
oppossum
(Monodelphis domestica)
Mammalia ZDHHC14 35
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zdhhc14 34
  • 89.75 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC14 35
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZDHHC14 34 35
  • 81.15 (n)
lizard
(Anolis carolinensis)
Reptilia ZDHHC14 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc14 34
  • 76.04 (n)
zebrafish
(Danio rerio)
Actinopterygii zdhhc14 34 35
  • 69.19 (n)
fruit fly
(Drosophila melanogaster)
Insecta app 35 34
  • 64.48 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dhhc-2 34 35
  • 51.91 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G26935 34
  • 51.4 (n)
rice
(Oryza sativa)
Liliopsida Os01g0925300 34
  • 52.86 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.6808 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3762 35
  • 54 (a)
OneToMany
Species where no ortholog for ZDHHC14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ZDHHC14 Gene

ENSEMBL:
Gene Tree for ZDHHC14 (if available)
TreeFam:
Gene Tree for ZDHHC14 (if available)

Paralogs for ZDHHC14 Gene

Paralogs for ZDHHC14 Gene

(5) SIMAP similar genes for ZDHHC14 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZDHHC14: view

Variants for ZDHHC14 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC14 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000011710 -- 157,631,371(+) TATTG(A/G)AATAT intron-variant
rs1000014528 -- 157,675,103(+) TTCCA(C/T)CTGCT intron-variant, downstream-variant-500B
rs1000027361 -- 157,391,947(+) GATTT(A/G)TGTAA intron-variant
rs1000029699 -- 157,554,744(+) AACGT(C/T)GGCAT intron-variant, nc-transcript-variant
rs1000066463 -- 157,604,255(+) GCGCT(C/G)CAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC14 Gene

Variant ID Type Subtype PubMed ID
dgv10984n54 CNV loss 21841781
dgv3420n106 CNV deletion 24896259
dgv3686e59 CNV insertion 20981092
dgv407e215 CNV deletion 23714750
esv1113682 CNV deletion 17803354
esv2076685 CNV deletion 18987734
esv2124670 CNV deletion 18987734
esv2610603 CNV deletion 19546169
esv2660140 CNV deletion 23128226
esv2732980 CNV deletion 23290073
esv2732981 CNV deletion 23290073
esv2732982 CNV deletion 23290073
esv2763603 CNV gain 21179565
esv28761 CNV gain 19812545
esv3282829 CNV deletion 24192839
esv33003 CNV loss 17666407
esv3306470 CNV mobile element insertion 20981092
esv3309699 CNV mobile element insertion 20981092
esv33371 CNV loss 17666407
esv33442 CNV loss 17666407
esv3431419 CNV insertion 20981092
esv3496 CNV loss 18987735
esv3540725 CNV deletion 23714750
esv3571486 CNV loss 25503493
esv3571488 CNV loss 25503493
esv3571489 CNV loss 25503493
esv6974 CNV loss 19470904
esv996138 CNV deletion 20482838
nsv1073599 CNV deletion 25765185
nsv1132024 CNV deletion 24896259
nsv509156 CNV insertion 20534489

Variation tolerance for ZDHHC14 Gene

Residual Variation Intolerance Score: 38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.69; 32.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZDHHC14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZDHHC14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC14 Gene

Disorders for ZDHHC14 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZDHHC14 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chromosome 6q24-q25 deletion syndrome
  • 6q25 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZDHHC14

Genetic Association Database (GAD)
ZDHHC14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZDHHC14
genes like me logo Genes that share disorders with ZDHHC14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZDHHC14 Gene

Publications for ZDHHC14 Gene

  1. Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D. (PMID: 22041458) Clark S.L. … van den Oord E.J. (Psychol Med 2012) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  5. Identification of ZDHHC14 as a novel human tumour suppressor gene. (PMID: 24407904) Yeste-Velasco M. … Lu Y.J. (J. Pathol. 2014) 3 64

Products for ZDHHC14 Gene

Sources for ZDHHC14 Gene

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