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Aliases for ZDHHC13 Gene

Aliases for ZDHHC13 Gene

  • Zinc Finger, DHHC-Type Containing 13 2 3
  • HIP14L 3 4 6
  • Huntingtin-Interacting Protein 14-Related Protein 3 4
  • Zinc Finger DHHC Domain-Containing Protein 13 3 4
  • Putative NF-Kappa-B-Activating Protein 209 3 4
  • Huntingtin-Interacting Protein HIP3RP 3 4
  • Putative MAPK-Activating Protein PM03 3 4
  • HIP14-Related Protein 3 4
  • DHHC-13 3 4
  • HIP3RP 3 4
  • Zinc Finger, DHHC Domain Containing 13 3
  • Huntingtin Interacting Protein HIP3RP 3
  • Probable Palmitoyltransferase ZDHHC13 3
  • Palmitoyltransferase ZDHHC13 3
  • EC 2.3.1.225 4
  • EC 2.3.1 63

External Ids for ZDHHC13 Gene

Previous GeneCards Identifiers for ZDHHC13 Gene

  • GC11P019104
  • GC11P018822

Summaries for ZDHHC13 Gene

GeneCards Summary for ZDHHC13 Gene

ZDHHC13 (Zinc Finger, DHHC-Type Containing 13) is a Protein Coding gene. GO annotations related to this gene include signal transducer activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC17.

UniProtKB/Swiss-Prot for ZDHHC13 Gene

  • Palmitoyltransferase for HD and GAD2. Mediates Mg(2+) transport.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC13 Gene

Genomics for ZDHHC13 Gene

Regulatory Elements for ZDHHC13 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZDHHC13 Gene

Start:
19,117,099 bp from pter
End:
19,176,422 bp from pter
Size:
59,324 bases
Orientation:
Plus strand

Genomic View for ZDHHC13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZDHHC13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC13 Gene

Proteins for ZDHHC13 Gene

  • Protein details for ZDHHC13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUH4-ZDH13_HUMAN
    Recommended name:
    Palmitoyltransferase ZDHHC13
    Protein Accession:
    Q8IUH4
    Secondary Accessions:
    • Q7Z2D3
    • Q86VK2
    • Q9NV30
    • Q9NV99

    Protein attributes for ZDHHC13 Gene

    Size:
    622 amino acids
    Molecular mass:
    70861 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91856.1; Type=Erroneous termination; Positions=482; Note=Translated as Cys.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZDHHC13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZDHHC13 Gene

Proteomics data for ZDHHC13 Gene at MOPED

Post-translational modifications for ZDHHC13 Gene

  • Ubiquitination at Lys80
  • Modification sites at PhosphoSitePlus

Other Protein References for ZDHHC13 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains for ZDHHC13 Gene

Gene Families for ZDHHC13 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing
  • ZDHHC :Zinc fingers, DHHC-type

Suggested Antigen Peptide Sequences for ZDHHC13 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IUH4

UniProtKB/Swiss-Prot:

ZDH13_HUMAN :
  • Q8IUH4
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
Similarity:
  • Contains 6 ANK repeats.
  • Contains 1 DHHC-type zinc finger.
genes like me logo Genes that share domains with ZDHHC13: view

Function for ZDHHC13 Gene

Molecular function for ZDHHC13 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA
UniProtKB/Swiss-Prot Function:
Palmitoyltransferase for HD and GAD2. Mediates Mg(2+) transport.

Enzyme Numbers (IUBMB) for ZDHHC13 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP 12761501
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0015095 magnesium ion transmembrane transporter activity ISS --
GO:0016409 palmitoyltransferase activity ISS --
genes like me logo Genes that share ontologies with ZDHHC13: view
genes like me logo Genes that share phenotypes with ZDHHC13: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZDHHC13

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZDHHC13 Gene

Localization for ZDHHC13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC13 Gene

Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi vesicles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZDHHC13 Gene COMPARTMENTS Subcellular localization image for ZDHHC13 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for ZDHHC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane ISS --
GO:0005783 endoplasmic reticulum IDA 16647879
GO:0005794 Golgi apparatus IDA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC13: view

Pathways for ZDHHC13 Gene

SuperPathways for ZDHHC13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IMP 12761501
GO:0008152 metabolic process ISS --
GO:0015693 magnesium ion transport IEA --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP 12761501
genes like me logo Genes that share ontologies with ZDHHC13: view

No data available for Pathways by source for ZDHHC13 Gene

Transcripts for ZDHHC13 Gene

Unigene Clusters for ZDHHC13 Gene

Zinc finger, DHHC-type containing 13:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZDHHC13

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC13 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17
SP1: -
SP2: - -
SP3: -
SP4:

Relevant External Links for ZDHHC13 Gene

GeneLoc Exon Structure for
ZDHHC13
ECgene alternative splicing isoforms for
ZDHHC13

Expression for ZDHHC13 Gene

mRNA expression in normal human tissues for ZDHHC13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZDHHC13 Gene

This gene is overexpressed in Esophagus - Mucosa (5.1).

Protein differential expression in normal tissues for ZDHHC13 Gene

This gene is overexpressed in Nasal epithelium (62.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZDHHC13 Gene

SOURCE GeneReport for Unigene cluster for ZDHHC13 Gene Hs.188569

genes like me logo Genes that share expressions with ZDHHC13: view

Expression partners for ZDHHC13 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ZDHHC13 Gene

Orthologs for ZDHHC13 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC13 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZDHHC13 35
  • 91.16 (n)
  • 89.39 (a)
ZDHHC13 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZDHHC13 35
  • 92.02 (n)
  • 91.96 (a)
ZDHHC13 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zdhhc13 35
  • 89.92 (n)
  • 91.16 (a)
Zdhhc13 16
Zdhhc13 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC13 35
  • 99.62 (n)
  • 99.04 (a)
ZDHHC13 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zdhhc13 35
  • 88.8 (n)
  • 90.35 (a)
oppossum
(Monodelphis domestica)
Mammalia ZDHHC13 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC13 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZDHHC13 35
  • 68.74 (n)
  • 65.47 (a)
ZDHHC13 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZDHHC13 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493145 35
  • 62.48 (n)
  • 61.26 (a)
zebrafish
(Danio rerio)
Actinopterygii wufi22e09 35
zdhhc13 35
  • 56.61 (n)
  • 51.91 (a)
zdhhc13 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hip14 36
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AKR1 36
  • 20 (a)
ManyToMany
AKR2 36
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11093 36
  • 39 (a)
OneToMany
Species with no ortholog for ZDHHC13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZDHHC13 Gene

ENSEMBL:
Gene Tree for ZDHHC13 (if available)
TreeFam:
Gene Tree for ZDHHC13 (if available)

Paralogs for ZDHHC13 Gene

Paralogs for ZDHHC13 Gene

Selected SIMAP similar genes for ZDHHC13 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZDHHC13: view

Variants for ZDHHC13 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC13 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1298286 -- 19,170,400(-) AATTC(A/C)CCaaa intron-variant
rs1393954 -- 19,162,497(-) AGGGT(A/G)TCCAA intron-variant
rs1393955 -- 19,162,377(-) ATCTA(A/T)GGCAC intron-variant
rs1393956 -- 19,151,343(+) CTGGT(A/G)TTTAT intron-variant
rs1393957 -- 19,151,364(+) ACTTA(C/T)GACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC13 Gene

Variant ID Type Subtype PubMed ID
esv2662583 CNV Deletion 23128226

Relevant External Links for ZDHHC13 Gene

HapMap Linkage Disequilibrium report
ZDHHC13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC13 Gene

Disorders for ZDHHC13 Gene

Relevant External Links for ZDHHC13

Genetic Association Database (GAD)
ZDHHC13

No disorders were found for ZDHHC13 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ZDHHC13 Gene

Publications for ZDHHC13 Gene

  1. Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport. (PMID: 18794299) Goytain A. … Quamme G.A. (J. Biol. Chem. 2008) 2 3 23
  2. HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis. (PMID: 12393793) Singaraja R.R. … Hayden M.R. (Hum. Mol. Genet. 2002) 3 4
  3. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A. … Sugano S. (Oncogene 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ZDHHC13 Gene

Sources for ZDHHC13 Gene

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