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Aliases for ZDHHC12 Gene

Aliases for ZDHHC12 Gene

  • Zinc Finger DHHC-Type Containing 12 2 3
  • Zinc Finger DHHC Domain-Containing Protein 12 3 4
  • Zinc Finger, DHHC-Type Containing 12 3 5
  • Zinc Finger Protein 400 3 4
  • DHHC-12 3 4
  • ZNF400 3 4
  • EC 2.3.1.225 4

External Ids for ZDHHC12 Gene

Previous GeneCards Identifiers for ZDHHC12 Gene

  • GC09M122597
  • GC09M123129
  • GC09M124936
  • GC09M126859
  • GC09M128562
  • GC09M130522
  • GC09M131484
  • GC09M101092

Summaries for ZDHHC12 Gene

GeneCards Summary for ZDHHC12 Gene

ZDHHC12 (Zinc Finger DHHC-Type Containing 12) is a Protein Coding gene. GO annotations related to this gene include protein-cysteine S-palmitoyltransferase activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC18.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC12 Gene

Genomics for ZDHHC12 Gene

Regulatory Elements for ZDHHC12 Gene

Promoters for ZDHHC12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZDHHC12 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZDHHC12 Gene

Chromosome:
9
Start:
128,720,869 bp from pter
End:
128,724,141 bp from pter
Size:
3,273 bases
Orientation:
Minus strand

Genomic View for ZDHHC12 Gene

Genes around ZDHHC12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC12 Gene

Proteins for ZDHHC12 Gene

  • Protein details for ZDHHC12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GR4-ZDH12_HUMAN
    Recommended name:
    Probable palmitoyltransferase ZDHHC12
    Protein Accession:
    Q96GR4
    Secondary Accessions:
    • A6NH95
    • B2RE03
    • Q5T265
    • Q5T267
    • Q5T268
    • Q86VT5
    • Q96T09

    Protein attributes for ZDHHC12 Gene

    Size:
    267 amino acids
    Molecular mass:
    30813 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZDHHC12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZDHHC12 Gene

Proteomics data for ZDHHC12 Gene at MOPED

Post-translational modifications for ZDHHC12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZDHHC12 Gene

No data available for DME Specific Peptides for ZDHHC12 Gene

Domains & Families for ZDHHC12 Gene

Gene Families for ZDHHC12 Gene

Protein Domains for ZDHHC12 Gene

Suggested Antigen Peptide Sequences for ZDHHC12 Gene

Graphical View of Domain Structure for InterPro Entry

Q96GR4

UniProtKB/Swiss-Prot:

ZDH12_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
  • Contains 1 DHHC-type zinc finger.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family.
Similarity:
  • Contains 1 DHHC-type zinc finger.
genes like me logo Genes that share domains with ZDHHC12: view

Function for ZDHHC12 Gene

Molecular function for ZDHHC12 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Enzyme Numbers (IUBMB) for ZDHHC12 Gene

genes like me logo Genes that share phenotypes with ZDHHC12: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ZDHHC12

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZDHHC12 Gene

Localization for ZDHHC12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC12 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZDHHC12 Gene COMPARTMENTS Subcellular localization image for ZDHHC12 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 3
cytoskeleton 2
extracellular 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for ZDHHC12 Gene

Pathways & Interactions for ZDHHC12 Gene

SuperPathways for ZDHHC12 Gene

No Data Available

Interacting Proteins for ZDHHC12 Gene

Gene Ontology (GO) - Biological Process for ZDHHC12 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC12 Gene

Drugs & Compounds for ZDHHC12 Gene

(1) Drugs for ZDHHC12 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for ZDHHC12 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
genes like me logo Genes that share compounds with ZDHHC12: view

Transcripts for ZDHHC12 Gene

Unigene Clusters for ZDHHC12 Gene

Zinc finger, DHHC-type containing 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC12 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e · 5f
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for ZDHHC12 Gene

GeneLoc Exon Structure for
ZDHHC12
ECgene alternative splicing isoforms for
ZDHHC12

Expression for ZDHHC12 Gene

mRNA expression in normal human tissues for ZDHHC12 Gene

mRNA differential expression in normal tissues according to GTEx for ZDHHC12 Gene

This gene is overexpressed in Whole Blood (x6.3).

SOURCE GeneReport for Unigene cluster for ZDHHC12 Gene Hs.133122

genes like me logo Genes that share expression patterns with ZDHHC12: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZDHHC12 Gene

Orthologs for ZDHHC12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZDHHC12 35
  • 91.39 (n)
  • 94.38 (a)
ZDHHC12 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZDHHC12 35
  • 92.32 (n)
  • 96.48 (a)
ZDHHC12 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zdhhc12 35
  • 86.02 (n)
  • 87.27 (a)
Zdhhc12 16
Zdhhc12 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC12 35
  • 99.25 (n)
  • 98.88 (a)
ZDHHC12 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zdhhc12 35
  • 87.64 (n)
  • 91.01 (a)
oppossum
(Monodelphis domestica)
Mammalia ZDHHC12 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC12 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZDHHC12 35
  • 62.89 (n)
  • 55.47 (a)
ZDHHC12 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZDHHC12 36
  • 26 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc12 35
  • 60.48 (n)
  • 58.87 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC569129 35
  • 63.98 (n)
  • 58.47 (a)
zdhhc12a 36
  • 47 (a)
OneToMany
zdhhc12b 36
  • 54 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Patsas 36
  • 12 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dhhc-13 36
  • 8 (a)
OneToMany
dhhc-14 36
  • 9 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AKR1 36
  • 8 (a)
ManyToMany
AKR2 36
  • 7 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToOne
Species with no ortholog for ZDHHC12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC12 Gene

ENSEMBL:
Gene Tree for ZDHHC12 (if available)
TreeFam:
Gene Tree for ZDHHC12 (if available)

Paralogs for ZDHHC12 Gene

Paralogs for ZDHHC12 Gene

genes like me logo Genes that share paralogs with ZDHHC12: view

Variants for ZDHHC12 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC12 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_023833 -
rs2900268 - 128,721,470(-) GGGTC(A/T)GTGGT reference, missense
rs10988103 -- 128,721,519(+) GGGAC(A/G)GGGGC intron-variant
rs10988104 -- 128,721,767(+) TCGTA(G/T)CGGCG reference, synonymous-codon
rs10988105 -- 128,722,247(+) GAGGG(C/T)GGCTG intron-variant

Variation tolerance for ZDHHC12 Gene

Residual Variation Intolerance Score: 74.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.01; 68.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZDHHC12 Gene

HapMap Linkage Disequilibrium report
ZDHHC12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZDHHC12 Gene

Disorders for ZDHHC12 Gene

Relevant External Links for ZDHHC12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZDHHC12

No disorders were found for ZDHHC12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC12 Gene

Publications for ZDHHC12 Gene

  1. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 67
  2. Genetic variants associated with disordered eating. (PMID: 23568457) Wade T.D. … Martin N.G. (Int J Eat Disord 2013) 3
  3. Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. (PMID: 24144296) Cheng C.Y. … Baird P.N. (Am. J. Hum. Genet. 2013) 3
  4. Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system. (PMID: 23034182) Ohno Y. … Kihara A. (Mol. Biol. Cell 2012) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for ZDHHC12 Gene

Sources for ZDHHC12 Gene

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