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Aliases for ZDHHC12 Gene

Aliases for ZDHHC12 Gene

  • Zinc Finger DHHC-Type Containing 12 2 3 5
  • Zinc Finger DHHC Domain-Containing Protein 12 3 4
  • Zinc Finger Protein 400 3 4
  • DHHC-12 3 4
  • ZNF400 3 4
  • Probable Palmitoyltransferase ZDHHC12 3
  • EC 4

External Ids for ZDHHC12 Gene

Previous GeneCards Identifiers for ZDHHC12 Gene

  • GC09M122597
  • GC09M123129
  • GC09M124936
  • GC09M126859
  • GC09M128562
  • GC09M130522
  • GC09M131484
  • GC09M101092

Summaries for ZDHHC12 Gene

GeneCards Summary for ZDHHC12 Gene

ZDHHC12 (Zinc Finger DHHC-Type Containing 12) is a Protein Coding gene. GO annotations related to this gene include protein-cysteine S-palmitoyltransferase activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC13.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC12 Gene

Genomics for ZDHHC12 Gene

Regulatory Elements for ZDHHC12 Gene

Enhancers for ZDHHC12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G128909 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -188.1 -188095 5.5 PKNOX1 FOXA2 ARID4B ZBTB7B YY1 TCF12 GLIS2 GATA2 FOS SP5 LRRC8A KYAT1 PHYHD1 DOLK NUP188 SPOUT1 LOC100506100 ZDHHC12 PKN3 GLE1
GH09G128633 1.6 Ensembl ENCODE dbSUPER 11.1 +88.0 88035 4.7 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 ZNF143 LOC101929270 LOC101929314 SPOUT1 PKN3 CDK9 ODF2 LOC100129352 LOC100506100 ZDHHC12 PTRH1
GH09G128844 1.5 Ensembl ENCODE dbSUPER 11.2 -121.7 -121740 2.2 HDGF PKNOX1 FOXA2 ARNT SIN3A TCF12 GATA2 FOS DEK NCOA1 SPOUT1 KYAT1 LRRC8A NUP188 DOLK TBC1D13 PHYHD1 ZDHHC12 LOC100506100 PKN3
GH09G128687 1.3 ENCODE dbSUPER 12.1 +34.5 34526 4.0 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 SIN3A DMAP1 ZNF2 YY1 ZNF143 LOC100506100 ZDHHC12 LOC105376287 PKN3
GH09G128682 1.3 ENCODE dbSUPER 12 +39.4 39377 4.9 HDGF FOXA2 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF143 DEK ZNF263 ZDHHC12 LOC100506100 PHYHD1 LOC105376287 SET
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZDHHC12 on UCSC Golden Path with GeneCards custom track

Promoters for ZDHHC12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ZDHHC12 Gene

128,720,869 bp from pter
128,724,141 bp from pter
3,273 bases
Minus strand

Genomic View for ZDHHC12 Gene

Genes around ZDHHC12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC12 Gene

Proteins for ZDHHC12 Gene

  • Protein details for ZDHHC12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable palmitoyltransferase ZDHHC12
    Protein Accession:
    Secondary Accessions:
    • A6NH95
    • B2RE03
    • Q5T265
    • Q5T267
    • Q5T268
    • Q86VT5
    • Q96T09

    Protein attributes for ZDHHC12 Gene

    267 amino acids
    Molecular mass:
    30813 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZDHHC12 Gene


neXtProt entry for ZDHHC12 Gene

Post-translational modifications for ZDHHC12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZDHHC12 Gene

Domains & Families for ZDHHC12 Gene

Gene Families for ZDHHC12 Gene

Protein Domains for ZDHHC12 Gene

Suggested Antigen Peptide Sequences for ZDHHC12 Gene

Graphical View of Domain Structure for InterPro Entry



  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
genes like me logo Genes that share domains with ZDHHC12: view

Function for ZDHHC12 Gene

Molecular function for ZDHHC12 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Enzyme Numbers (IUBMB) for ZDHHC12 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016409 palmitoyltransferase activity IDA 23034182
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC12: view
genes like me logo Genes that share phenotypes with ZDHHC12: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ZDHHC12

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZDHHC12 Gene

Localization for ZDHHC12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC12 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC12 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 3
extracellular 2
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for ZDHHC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 16647879
GO:0005794 Golgi apparatus IDA 16647879
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC12: view

Pathways & Interactions for ZDHHC12 Gene

SuperPathways for ZDHHC12 Gene

No Data Available

Interacting Proteins for ZDHHC12 Gene

Gene Ontology (GO) - Biological Process for ZDHHC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018345 protein palmitoylation IDA 23034182
genes like me logo Genes that share ontologies with ZDHHC12: view

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC12 Gene

Drugs & Compounds for ZDHHC12 Gene

(1) Drugs for ZDHHC12 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for ZDHHC12 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZDHHC12: view

Transcripts for ZDHHC12 Gene

Unigene Clusters for ZDHHC12 Gene

Zinc finger, DHHC-type containing 12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC12 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e · 5f
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - -
SP5: -

Relevant External Links for ZDHHC12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZDHHC12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZDHHC12 Gene

mRNA differential expression in normal tissues according to GTEx for ZDHHC12 Gene

This gene is overexpressed in Whole Blood (x6.3).

NURSA nuclear receptor signaling pathways regulating expression of ZDHHC12 Gene:


SOURCE GeneReport for Unigene cluster for ZDHHC12 Gene:

genes like me logo Genes that share expression patterns with ZDHHC12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC12 Gene

Orthologs for ZDHHC12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZDHHC12 34 35
  • 99.25 (n)
(Canis familiaris)
Mammalia ZDHHC12 34 35
  • 92.32 (n)
(Bos Taurus)
Mammalia ZDHHC12 34 35
  • 91.39 (n)
(Rattus norvegicus)
Mammalia Zdhhc12 34
  • 87.64 (n)
(Mus musculus)
Mammalia Zdhhc12 34 16 35
  • 86.02 (n)
(Monodelphis domestica)
Mammalia ZDHHC12 35
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia ZDHHC12 35
  • 68 (a)
(Gallus gallus)
Aves ZDHHC12 34 35
  • 62.89 (n)
(Anolis carolinensis)
Reptilia ZDHHC12 35
  • 26 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc12 34
  • 60.48 (n)
(Danio rerio)
Actinopterygii LOC569129 34
  • 63.98 (n)
zdhhc12b 35
  • 54 (a)
zdhhc12a 35
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta Patsas 35
  • 12 (a)
(Caenorhabditis elegans)
Secernentea dhhc-14 35
  • 9 (a)
dhhc-13 35
  • 8 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AKR1 35
  • 8 (a)
AKR2 35
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
Species where no ortholog for ZDHHC12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC12 Gene

Gene Tree for ZDHHC12 (if available)
Gene Tree for ZDHHC12 (if available)

Paralogs for ZDHHC12 Gene

Paralogs for ZDHHC12 Gene

genes like me logo Genes that share paralogs with ZDHHC12: view

Variants for ZDHHC12 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC12 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1001029491 -- 128,723,737(+) GTGGG(C/T)ACCGG intron-variant, upstream-variant-2KB
rs1002020588 -- 128,720,804(+) CCAGC(G/T)CGCCC intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1002170123 -- 128,722,974(+) CCAGC(A/G)TCTCT intron-variant, upstream-variant-2KB
rs1002304604 -- 128,722,621(+) ACAGG(A/T)GTGGG intron-variant, upstream-variant-2KB, reference, synonymous-codon
rs1003023282 -- 128,721,902(+) TTCTG(A/G)AAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC12 Gene

Variant ID Type Subtype PubMed ID
nsv951777 CNV deletion 24416366

Variation tolerance for ZDHHC12 Gene

Residual Variation Intolerance Score: 74.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.01; 68.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZDHHC12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC12 Gene

Disorders for ZDHHC12 Gene

Relevant External Links for ZDHHC12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZDHHC12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC12 Gene

Publications for ZDHHC12 Gene

  1. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. (PMID: 24144296) Cheng C.Y. … Baird P.N. (Am. J. Hum. Genet. 2013) 3 64

Products for ZDHHC12 Gene

Sources for ZDHHC12 Gene

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