ZDHHC12 Gene
protein-coding GIFtS: 45
GCID: GC09M131484
|
|
zinc finger, DHHC-type containing 12
| |
Aliases for ZDHHC12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Zinc Finger, DHHC-Type Containing 121 2 | | FLJ145241 | | ZNF4001 2 3 | | Probable Palmitoyltransferase ZDHHC122 | | Zinc Finger DHHC Domain-Containing Protein 122 3 | | Zinc Finger, DHHC Domain Containing 122 | | Zinc Finger Protein 4002 3 | | EC 2.3.1.-3 | | DHHC-122 3 | | |
Export aliases for ZDHHC12 gene to outside databasesPrevious GC identifers: GC09M122597 GC09M123129 GC09M124936 GC09M126859 GC09M128562 GC09M130522 GC09M101092 |
Summaries for ZDHHC12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| -- |
Genomic Views for ZDHHC12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ZDHHC12 gene promoter: HOXA9B HOXA9 AhR p53 Sp1 Olf-1 Ik-3 Pax-3 Meis-1a Meis-1 Other transcription factors
Search SABiosciences Chromatin IP Primers for ZDHHC12
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZDHHC12 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.11 Ensembl cytogenetic band: 9q34.11 HGNC cytogenetic band: 9q34.11ZDHHC12 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M131484: view genomic region
(about GC identifiers)
Start:
|
131,483,148 bp from pter |
End:
|
131,486,408 bp from pter |
Size:
|
3,261 bases |
Orientation:
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minus strand |
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Proteins for ZDHHC12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: ZDH12_HUMAN, Q96GR4 (See
protein sequence)Recommended Name: Probable palmitoyltransferase ZDHHC12 Size: 267 amino acids; 30813 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: A6NH95 B2RE03 Q5T265 Q5T267 Q5T268 Q86VT5 Q96T09Alternative splicing: 3 isoforms: Q96GR4-1 Q96GR4-2 Q96GR4-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZDHHC12: NX_Q96GR4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96GR4 ZDHHC12 Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins: NP_116188.2 ENSEMBL proteins: ENSP00000361748 ENSP00000361757 ENSP00000361752 ENSP00000387587 ENSP00000384205 Human Recombinant Protein Products for ZDHHC12:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
ZDHHC12 for ontologies About GeneDecksing
ZDHHC12 Antibody Products: Assay Products for ZDHHC12: |
Protein
Domains / Families for ZDHHC12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZDHHC12 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96GR4ProtoNet protein and cluster: Q96GR4 1 Blocks protein family: IPB001594 Zn-finger
UniProtKB/Swiss-Prot: ZDH12_HUMAN, Q96GR4Domain: The DHHC domain is required for palmitoyltransferase activity (By similarity)Similarity: Belongs to the DHHC palmitoyltransferase familySimilarity: Contains 1 DHHC-type zinc finger |
Function for ZDHHC12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: ZDH12_HUMAN, Q96GR4Catalytic activity: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA Enzyme Number (IUBMB): EC 2.3.1.-1
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- | | GO:0016746 | transferase activity, transferring acyl groups |
IEA | -- |
ZDHHC12 for ontologies About GeneDecksing
Phenotypes: 1 GenomeRNAi human phenotype for ZDHHC12: Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC12 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC12 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZDHHC12 (NM_032799) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC12 |
|
Pathways & Interactions for ZDHHC12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZDHHC12
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
 2 Interacting proteins for ZDHHC12 (Q96GR42 ENSP000003617484) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds for ZDHHC12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for ZDHHC12 Search CenterWatch for drugs/clinical trials and news about ZDHHC12 / ZDH12 
|
Transcripts for ZDHHC12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for ZDHHC12 gene: NM_032799.4 Unigene Cluster for ZDHHC12: Zinc finger, DHHC-type containing 12 Hs.133122 [show with all ESTs]Unigene Representative Sequence: BM5497956 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372663 ENST00000372672 ENST00000372667(uc004bvy.3) ENST00000467312(uc004bvz.3) ENST00000452105 ENST00000406904
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC12 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZDHHC12 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZDHHC12 (NM_032799) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZDHHC12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZDHHC12  |
Additional cDNA sequence: AK027430.1 AK075332.1 AK315746.1 BC009280.2 BC048251.1 8 DOTS entries: DT.100791009 DT.431137 DT.95269918 DT.100791008 DT.121168639 DT.100791007 DT.100791013 DT.95269920 24/128 AceView cDNA sequences (see all 128): BC009280 CA423921 AI865685 BM760554 BE466136 AI540476 AI612822 BM789831 AI659921 BC048251 AA383098 BM849939 AW251027 NM_032799 BX280106 AI650672 CA488512 BM844241 BQ436542 BM746766 BF684252 AW084791 BI089775 AW007586 GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC12 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | · | 5f | |
| SP1: | |   | |   | - |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | - |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |
| SP4: | |   | |   | - |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for ZDHHC12
|
Expression for ZDHHC12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZDHHC12 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GTCAGGCCTC
 About this image See ZDHHC12 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ZDHHC12
SOURCE GeneReport for Unigene cluster: Hs.133122 SABiosciences Custom PCR Arrays for ZDHHC12
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZDHHC12 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZDHHC12 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZDHHC12 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZDHHC12 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC12 |
Orthologs for ZDHHC12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ZDHHC12 gene from 4/18 species (see all 18) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
ZDHHC121 |
zinc finger, DHHC-type containing 12 |
62.82(n) 54.98(a) |
  |
417207 XM_415490.3 XP_415490.1 |
zebrafish (Danio rerio) |
Actinopterygii |
LOC5691291 |
probable palmitoyltransferase ZDHHC12-like |
63.05(n) 58.23(a) |
  |
569129 XM_692494.4 XP_697586.4 |
thale cress (Arabidopsis thaliana) |
eudicotyledons |
AT3G513901 |
putative S-acyltransferase |
45.53(n) 39.22(a) |
  |
824302 NM_114998.4 NP_566950.1 |
rice (Oryza sativa) |
Liliopsida |
---- |
DHHC zinc finger domain containing protein, expres...DHHC zinc finger domain containing protein, expres... |
21(a)20(a) |
1 ↔ many1 ↔ many |
12(17613370-17617950) 4(27945970-27951649) |
ENSEMBL Gene Tree for ZDHHC12 (if available) TreeFam Gene Tree for ZDHHC12 (if available)  |
Paralogs for ZDHHC12 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for ZDHHC12 gene
- ZDHHC142 ZDHHC52 ZDHHC82 ZDHHC192 ZDHHC182 ZDHHC92
ZDHHC12 for paralogs About GeneDecksing
|
Genomic Variants for ZDHHC12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 9 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for ZDHHC12 (131483148 - 131486408 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ZDHHC12: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZDHHC12 |
|
Disorders
/ Diseases for ZDHHC12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZDHHC12 for disorders About GeneDecksing
3 diseases for ZDHHC12: About MalaCardsneuronal ceroid-lipofuscinosis ceroid lipofuscinosis neuronitis Export disorders for ZDHHC12 gene to outside databases
|
Publications for ZDHHC12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZDHHC12 gene integrated from 9 sources: (articles sorted by number of sources associating them with ZDHHC12) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The structurally disordered KRAB repression domain is incorporated into a protease resistant core upon binding to KAP-1-RBCC domain. (PubMed id 17512541)9 Peng H....Rauscher F.J. (2007)
- Expression, purification and partial characterization of the Kruppel-associated box (KRAB) from the human ZNF2 protein. (PubMed id 16101389)9 Rivieccio V....Grimaldi G. (2005)
|
External Searches for ZDHHC12 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ZDHHC12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZDHHC12 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZDHHC12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for ZDHHC12 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZDHHC12 gene: Search GeneIP for patents involving ZDHHC12
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for ZDHHC12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
 | |
 | |
 |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZDHHC12 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZDHHC12 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZDHHC12 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZDHHC12 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZDHHC12 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZDHHC12 |
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 | | ZDHHC12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC12 |
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