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Aliases for ZDHHC12 Gene

Aliases for ZDHHC12 Gene

  • Zinc Finger, DHHC-Type Containing 12 2 3
  • Zinc Finger DHHC Domain-Containing Protein 12 3 4
  • Zinc Finger Protein 400 3 4
  • DHHC-12 3 4
  • ZNF400 3 4
  • Zinc Finger, DHHC Domain Containing 12 3
  • Probable Palmitoyltransferase ZDHHC12 3
  • EC 2.3.1.225 4

External Ids for ZDHHC12 Gene

Previous GeneCards Identifiers for ZDHHC12 Gene

  • GC09M122597
  • GC09M123129
  • GC09M124936
  • GC09M126859
  • GC09M128562
  • GC09M130522
  • GC09M131484
  • GC09M101092

Summaries for ZDHHC12 Gene

GeneCards Summary for ZDHHC12 Gene

ZDHHC12 (Zinc Finger, DHHC-Type Containing 12) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring acyl groups. An important paralog of this gene is ZDHHC17.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC12 Gene

Genomics for ZDHHC12 Gene

Regulatory Elements for ZDHHC12 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZDHHC12 Gene

Start:
128,720,869 bp from pter
End:
128,724,129 bp from pter
Size:
3,261 bases
Orientation:
Minus strand

Genomic View for ZDHHC12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZDHHC12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC12 Gene

Proteins for ZDHHC12 Gene

  • Protein details for ZDHHC12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GR4-ZDH12_HUMAN
    Recommended name:
    Probable palmitoyltransferase ZDHHC12
    Protein Accession:
    Q96GR4
    Secondary Accessions:
    • A6NH95
    • B2RE03
    • Q5T265
    • Q5T267
    • Q5T268
    • Q86VT5
    • Q96T09

    Protein attributes for ZDHHC12 Gene

    Size:
    267 amino acids
    Molecular mass:
    30813 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZDHHC12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZDHHC12 Gene

Proteomics data for ZDHHC12 Gene at MOPED

Post-translational modifications for ZDHHC12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZDHHC12 Gene

No data available for DME Specific Peptides for ZDHHC12 Gene

Domains for ZDHHC12 Gene

Gene Families for ZDHHC12 Gene

HGNC:
  • ZDHHC :Zinc fingers, DHHC-type

Protein Domains for ZDHHC12 Gene

Suggested Antigen Peptide Sequences for ZDHHC12 Gene

Graphical View of Domain Structure for InterPro Entry

Q96GR4

UniProtKB/Swiss-Prot:

ZDH12_HUMAN :
  • Q96GR4
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family.
Similarity:
  • Contains 1 DHHC-type zinc finger.
genes like me logo Genes that share domains with ZDHHC12: view

Function for ZDHHC12 Gene

Molecular function for ZDHHC12 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA

Enzyme Numbers (IUBMB) for ZDHHC12 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016409 palmitoyltransferase activity IDA 23034182
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC12: view

Phenotypes for ZDHHC12 Gene

GenomeRNAi human phenotypes for ZDHHC12:
genes like me logo Genes that share phenotypes with ZDHHC12: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZDHHC12 Gene

Localization for ZDHHC12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC12 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZDHHC12 Gene COMPARTMENTS Subcellular localization image for ZDHHC12 gene
Compartment Confidence
plasma membrane 3
extracellular 2

Gene Ontology (GO) - Cellular Components for ZDHHC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 16647879
GO:0005794 Golgi apparatus IDA 16647879
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC12: view

Pathways for ZDHHC12 Gene

SuperPathways for ZDHHC12 Gene

No Data Available

Interacting Proteins for ZDHHC12 Gene

Gene Ontology (GO) - Biological Process for ZDHHC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0018345 protein palmitoylation IDA 23034182
genes like me logo Genes that share ontologies with ZDHHC12: view

No data available for Pathways by source for ZDHHC12 Gene

Transcripts for ZDHHC12 Gene

Unigene Clusters for ZDHHC12 Gene

Zinc finger, DHHC-type containing 12:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZDHHC12

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZDHHC12

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC12 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e · 5f
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for ZDHHC12 Gene

GeneLoc Exon Structure for
ZDHHC12
ECgene alternative splicing isoforms for
ZDHHC12

Expression for ZDHHC12 Gene

mRNA expression in normal human tissues for ZDHHC12 Gene

mRNA differential expression in normal tissues according to GTEx for ZDHHC12 Gene

This gene is overexpressed in Whole Blood (6.3).

SOURCE GeneReport for Unigene cluster for ZDHHC12 Gene Hs.133122

genes like me logo Genes that share expressions with ZDHHC12: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for ZDHHC12 Gene

Orthologs for ZDHHC12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC12 35
  • 99.25 (n)
  • 98.88 (a)
ZDHHC12 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZDHHC12 35
  • 91.39 (n)
  • 94.38 (a)
ZDHHC12 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZDHHC12 35
  • 92.32 (n)
  • 96.48 (a)
ZDHHC12 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zdhhc12 35
  • 86.02 (n)
  • 87.27 (a)
Zdhhc12 16
Zdhhc12 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZDHHC12 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC12 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zdhhc12 35
  • 87.64 (n)
  • 91.01 (a)
chicken
(Gallus gallus)
Aves ZDHHC12 35
  • 62.89 (n)
  • 55.47 (a)
ZDHHC12 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZDHHC12 36
  • 26 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc12 35
  • 60.48 (n)
  • 58.87 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC569129 35
  • 63.98 (n)
  • 58.47 (a)
zdhhc12a 36
  • 47 (a)
OneToMany
zdhhc12b 36
  • 54 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Patsas 36
  • 12 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dhhc-13 36
  • 8 (a)
OneToMany
dhhc-14 36
  • 9 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AKR1 36
  • 8 (a)
ManyToMany
AKR2 36
  • 7 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToOne
Species with no ortholog for ZDHHC12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC12 Gene

ENSEMBL:
Gene Tree for ZDHHC12 (if available)
TreeFam:
Gene Tree for ZDHHC12 (if available)

Paralogs for ZDHHC12 Gene

Paralogs for ZDHHC12 Gene

genes like me logo Genes that share paralogs with ZDHHC12: view

Variants for ZDHHC12 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC12 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs2900268 - 128,721,470(-) GGGTC(A/T)GTGGT reference, missense
rs10988103 -- 128,721,519(+) GGGAC(A/G)GGGGC intron-variant
rs10988104 -- 128,721,767(+) TCGTA(G/T)CGGCG synonymous-codon, reference
rs10988105 -- 128,722,247(+) GAGGG(C/T)GGCTG intron-variant
rs12001017 -- 128,721,924(+) AGGGG(C/T)GAGGC intron-variant

Relevant External Links for ZDHHC12 Gene

HapMap Linkage Disequilibrium report
ZDHHC12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZDHHC12 Gene

Disorders for ZDHHC12 Gene

No disorders were found for ZDHHC12 Gene.

No data available for UniProtKB/Swiss-Prot for ZDHHC12 Gene

Publications for ZDHHC12 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  5. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. (PMID: 16647879) Ohno Y. … Igarashi Y. (Biochim. Biophys. Acta 2006) 3

Products for ZDHHC12 Gene

Sources for ZDHHC12 Gene

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