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Aliases for ZDHHC11B Gene

Aliases for ZDHHC11B Gene

  • Zinc Finger DHHC-Type Containing 11B 2 3
  • Zinc Finger DHHC Domain-Containing Protein 11B 3 4
  • Zinc Finger, DHHC-Type Containing 11B 3 5
  • DHHC-11B 3 4
  • Probable Palmitoyltransferase ZDHHC11B 3
  • EC 2.3.1.225 4

External Ids for ZDHHC11B Gene

Previous GeneCards Identifiers for ZDHHC11B Gene

  • GC05M000769

Summaries for ZDHHC11B Gene

GeneCards Summary for ZDHHC11B Gene

ZDHHC11B (Zinc Finger DHHC-Type Containing 11B) is a Protein Coding gene. GO annotations related to this gene include protein-cysteine S-palmitoyltransferase activity. An important paralog of this gene is ZDHHC4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC11B Gene

Genomics for ZDHHC11B Gene

Regulatory Elements for ZDHHC11B Gene

Genomic Location for ZDHHC11B Gene

Chromosome:
5
Start:
710,355 bp from pter
End:
784,749 bp from pter
Size:
74,395 bases
Orientation:
Minus strand

Genomic View for ZDHHC11B Gene

Genes around ZDHHC11B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC11B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC11B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC11B Gene

Proteins for ZDHHC11B Gene

  • Protein details for ZDHHC11B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C7U3-ZH11B_HUMAN
    Recommended name:
    Probable palmitoyltransferase ZDHHC11B
    Protein Accession:
    P0C7U3
    Secondary Accessions:
    • A6NHR3

    Protein attributes for ZDHHC11B Gene

    Size:
    371 amino acids
    Molecular mass:
    41895 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZDHHC11B Gene

Proteomics data for ZDHHC11B Gene at MOPED

Post-translational modifications for ZDHHC11B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZDHHC11B Gene

No data available for DME Specific Peptides for ZDHHC11B Gene

Domains & Families for ZDHHC11B Gene

Gene Families for ZDHHC11B Gene

Protein Domains for ZDHHC11B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZDHHC11B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0C7U3

UniProtKB/Swiss-Prot:

ZH11B_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
  • Contains 1 DHHC-type zinc finger.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family.
Similarity:
  • Contains 1 DHHC-type zinc finger.
genes like me logo Genes that share domains with ZDHHC11B: view

Function for ZDHHC11B Gene

Molecular function for ZDHHC11B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Enzyme Numbers (IUBMB) for ZDHHC11B Gene

Phenotypes for ZDHHC11B Gene

GenomeRNAi human phenotypes for ZDHHC11B:
genes like me logo Genes that share phenotypes with ZDHHC11B: view

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZDHHC11B Gene

Localization for ZDHHC11B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC11B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZDHHC11B Gene COMPARTMENTS Subcellular localization image for ZDHHC11B gene
Compartment Confidence
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for ZDHHC11B Gene

Pathways & Interactions for ZDHHC11B Gene

SuperPathways for ZDHHC11B Gene

No Data Available

Interacting Proteins for ZDHHC11B Gene

Gene Ontology (GO) - Biological Process for ZDHHC11B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC11B Gene

Drugs & Compounds for ZDHHC11B Gene

(1) Drugs for ZDHHC11B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for ZDHHC11B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
genes like me logo Genes that share compounds with ZDHHC11B: view

Transcripts for ZDHHC11B Gene

mRNA/cDNA for ZDHHC11B Gene

(17) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC11B Gene

No ASD Table

Relevant External Links for ZDHHC11B Gene

GeneLoc Exon Structure for
ZDHHC11B
ECgene alternative splicing isoforms for
ZDHHC11B

Expression for ZDHHC11B Gene

mRNA expression in normal human tissues for ZDHHC11B Gene

mRNA differential expression in normal tissues according to GTEx for ZDHHC11B Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.6) and Brain - Cerebellum (x4.3).

Protein differential expression in normal tissues from HIPED for ZDHHC11B Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZDHHC11B Gene



genes like me logo Genes that share expression patterns with ZDHHC11B: view

Protein tissue co-expression partners for ZDHHC11B Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZDHHC11B Gene

Orthologs for ZDHHC11B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC11B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 95 (a)
OneToMany
ZDHHC11B 35
  • 96.51 (n)
  • 95.18 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 44 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zdhhc11 36
  • 52 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 47 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 53 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CU694320.1 36
  • 32 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17075 36
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dhhc-11 36
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERF2 36
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10560 36
  • 26 (a)
OneToMany
Species with no ortholog for ZDHHC11B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZDHHC11B Gene

ENSEMBL:
Gene Tree for ZDHHC11B (if available)
TreeFam:
Gene Tree for ZDHHC11B (if available)

Paralogs for ZDHHC11B Gene

Paralogs for ZDHHC11B Gene

(4) SIMAP similar genes for ZDHHC11B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZDHHC11B: view

Variants for ZDHHC11B Gene

Sequence variations from dbSNP and Humsavar for ZDHHC11B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1809933 - 766,795(-) CTTCC(A/C/G)GGTGG nc-transcript-variant, reference, missense, utr-variant-5-prime
rs634901 - 751,163(-) ACCCC(A/G)GGGTG nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs3817063 - 748,506(-) TGCAG(C/G)TGCAG reference, missense
rs377769 -- 769,594(+) TGCAC(A/G)TTCCT intron-variant, utr-variant-5-prime
rs408244 -- 776,805(+) CTCAG(C/G)TCCCA intron-variant

Variation tolerance for ZDHHC11B Gene

Gene Damage Index Score: 6.32; 76.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZDHHC11B Gene

HapMap Linkage Disequilibrium report
ZDHHC11B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZDHHC11B Gene

Disorders for ZDHHC11B Gene

No disorders were found for ZDHHC11B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for ZDHHC11B Gene

Publications for ZDHHC11B Gene

  1. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 3 4 67

Products for ZDHHC11B Gene

Sources for ZDHHC11B Gene

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