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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZDHHC11B Gene

protein-coding   GIFtS: 29
GCID: GC05M000710          (predicted)

Zinc Finger, DHHC-Type Containing 11B

  Search for ZDHHC11B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger, DHHC-Type Containing 11B1 2
DHHC-11B2 3
Zinc Finger DHHC Domain-Containing Protein 11B2 3
Probable Palmitoyltransferase ZDHHC11B2
EC 2.3.1.-3

External Ids:    HGNC: 329621   Entrez Gene: 6530822   Ensembl: ENSG000002060777   UniProtKB: P0C7U33   

Export aliases for ZDHHC11B gene to outside databases

Previous GC identifer: GC05M000769


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZDHHC11B Gene: 
ZDHHC11B (zinc finger, DHHC-type containing 11B) is a protein-coding gene. GO annotations related to this gene include transferase activity, transferring acyl groups and zinc ion binding. An important paralog of this gene is ZDHHC1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZDHHC11B gene promoter:
         RFX1   Sox5   Tal-1   POU3F2   Tal-1beta   E47   Zic1   HSF2   Sox9   ITF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZDHHC11B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZDHHC11B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.33   Ensembl cytogenetic band:  5p15.33   HGNC cytogenetic band: 5p15.33

ZDHHC11B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZDHHC11B gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M000710:  view genomic region     (about GC identifiers)

Start:
710,475 bp from pter      End:
767,067 bp from pter
Size:
56,593 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZH11B_HUMAN, P0C7U3 (See protein sequence)
Recommended Name: Probable palmitoyltransferase ZDHHC11B  
Size: 371 amino acids; 41895 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: A6NHR3

Explore the universe of human proteins at neXtProt for ZDHHC11B: NX_P0C7U3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P0C7U3

  • ZDHHC11B Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

    ENSEMBL proteins: 
     ENSP00000442373   ENSP00000445280  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    ZDHHC11B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZDHHC: Zinc fingers, DHHC-type

    1 InterPro protein domain:
     IPR001594 Znf_DHHC_palmitoyltrfase

    Graphical View of Domain Structure for InterPro Entry P0C7U3

    ProtoNet protein and cluster: P0C7U3

    UniProtKB/Swiss-Prot: ZH11B_HUMAN, P0C7U3
    Domain: The DHHC domain is required for palmitoyltransferase activity (By similarity)
    Similarity: Belongs to the DHHC palmitoyltransferase family
    Similarity: Contains 1 DHHC-type zinc finger


    ZDHHC11B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZH11B_HUMAN, P0C7U3
    Catalytic activity: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA

         Enzyme Number (IUBMB): EC 2.3.1.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
    GO:0016746transferase activity, transferring acyl groups IEA--
         
    ZDHHC11B for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Zdhhc11 (no phenotypes)

    ZDHHC11B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Zdhhc11tm1(KOMP)Vlcg for ZDHHC11B

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZDHHC11B

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZDHHC11B (ZH11B)

    Search CenterWatch for drugs/clinical trials and news about ZDHHC11B / ZH11B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000522356 ENST00000508859 ENST00000382776
    miRNA
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZDHHC11B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZDHHC11B Expression
    About this image

        SABiosciences Custom PCR Arrays for ZDHHC11B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC11B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ZDHHC11B gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zdhhc111 , 5 zinc finger, DHHC domain containing 111, 5 68.51(n)1
    59.86(a)1
      13 (40.15 cM)5
    711641  NM_027704.21  NP_081980.11 
     739638625 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003341981 probable palmitoyltransferase ZDHHC11-like 57.9(n)
    48.52(a)
      100334198  XM_002665605.2  XP_002665651.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG170756
    --
    10(a)
    1 → many
    2L(260379-267505)
    worm
    (Caenorhabditis elegans)
    Secernentea dhhc-116
    Protein T22E7.2
    19(a)
    1 → many
    I(5764030-5768190)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SWF16
    Palmitoyltransferase that acts on transmembrane pr...
    12(a)
    1 → many
    IV(703234-704244)


    ENSEMBL Gene Tree for ZDHHC11B (if available)
    TreeFam Gene Tree for ZDHHC11B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZDHHC11B gene
    ZDHHC12  ZDHHC142  ZDHHC112  ZDHHC52  ZDHHC42  ZDHHC82  ZDHHC192  ZDHHC92  
    ZDHHC182  
    4 SIMAP similar genes for ZDHHC11B using alignment to 2 protein entries:     ZH11B_HUMAN (see all proteins):
    ZDHHC11    ZDHHC1    ZDHHC5    ZDHHC18

    ZDHHC11B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1372 SNPs in ZDHHC11B are shown (see all 1372)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1456640651,2
    C--720576(+) TCTTAC/GAGGAC 1 -- int10--------
    rs1394042811,2
    --720586(+) CATAAG/TAAATG 1 -- int10--------
    rs125229801,2
    C,H--720845(+) agaaaA/Gtcaga 1 -- int10--------
    rs96863191,2
    C--720971(+) tgggtC/Tgacaa 1 -- int10--------
    rs1484246541,2
    C--721044(+) ACCTCA/TAGGAC 1 -- int10--------
    rs1441236371,2
    C--721329(+) AGCAAA/C/GAAAAG 1 -- int10--------
    rs1464880271,2
    --721332(+) AAAAAA/GAGAAA 1 -- int10--------
    rs3811641,2
    C--721493(-) TCTAGT/GTGGGT 1 -- int11Minor allele frequency- G:0.00NA 2
    rs1899984301,2
    C--721523(+) AAACTC/TGTAAC 1 -- int10--------
    rs562391991,2
    C,F--721552(+) GAGATA/TGAAAC 1 -- int15Minor allele frequency- T:0.30NA WA 10

    HapMap Linkage Disequilibrium report for ZDHHC11B (710475 - 767067 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ZDHHC11B: --
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    Search QIAGEN SeqTarget long-range PCR primers for resequencing ZDHHC11B
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed article for ZDHHC11B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZDHHC11B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)1, 2 Schmutz J.... Rubin E.M. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 653082 HGNC: 32962 Ensembl:ENSG00000206077 euGenes: HUgn653082 ECgene: ZDHHC11B
    H-InvDB: ZDHHC11B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZDHHC11B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZDHHC11B gene:
    Search GeneIP for patents involving ZDHHC11B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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     Proteins for ZDHHC11B
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for ZDHHC11B
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     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZDHHC11B
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ZDHHC11B
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZDHHC11B
    Customized:
     lentivirus for stable overexpression of ZDHHC11B
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     adenovirus for overexpression of ZDHHC11B
     LSBio Antibodies in human, mouse, rat for ZDHHC11B
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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