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ZDHHC11B Gene

protein-coding   GIFtS: 29
GCID: GC05M000710          (predicted)

Zinc Finger, DHHC-Type Containing 11B

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, DHHC-Type Containing 11B1 2
DHHC-11B2 3
Zinc Finger DHHC Domain-Containing Protein 11B2 3
Probable Palmitoyltransferase ZDHHC11B2
EC 2.3.1.2253

External Ids:    HGNC: 329621   Entrez Gene: 6530822   Ensembl: ENSG000002060777   UniProtKB: P0C7U33   

Export aliases for ZDHHC11B gene to outside databases

Previous GC identifer: GC05M000769


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZDHHC11B Gene:
ZDHHC11B (zinc finger, DHHC-type containing 11B) is a protein-coding gene. GO annotations related to this gene include transferase activity, transferring acyl groups. An important paralog of this gene is ZDHHC1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ZDHHC11B gene promoter:
         RFX1   Sox5   Tal-1   POU3F2   Tal-1beta   E47   Zic1   HSF2   Sox9   ITF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZDHHC11B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.33   Ensembl cytogenetic band:  5p15.33   HGNC cytogenetic band: 5p15.33

ZDHHC11B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZDHHC11B gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M000710:  view genomic region     (about GC identifiers)

Start:
710,475 bp from pter      End:
767,067 bp from pter
Size:
56,593 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZH11B_HUMAN, P0C7U3 (See protein sequence)
Recommended Name: Probable palmitoyltransferase ZDHHC11B  
Size: 371 amino acids; 41895 Da
Secondary accessions: A6NHR3

Explore the universe of human proteins at neXtProt for ZDHHC11B: NX_P0C7U3

Explore proteomics data for ZDHHC11B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZDHHC11B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


    ENSEMBL proteins: 
     ENSP00000442373   ENSP00000445280  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZDHHC: Zinc fingers, DHHC-type

    1 InterPro protein domain:
     IPR001594 Znf_DHHC_palmitoyltrfase

    Graphical View of Domain Structure for InterPro Entry P0C7U3

    ProtoNet protein and cluster: P0C7U3

    UniProtKB/Swiss-Prot: ZH11B_HUMAN, P0C7U3
    Domain: The DHHC domain is required for palmitoyltransferase activity (By similarity)
    Similarity: Belongs to the DHHC palmitoyltransferase family
    Similarity: Contains 1 DHHC-type zinc finger


    Find genes that share domains with ZDHHC11B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZH11B_HUMAN, P0C7U3
    Catalytic activity: Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA

         Enzyme Number (IUBMB): EC 2.3.1.2251

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
    GO:0016746transferase activity, transferring acyl groups ----
    GO:0019706protein-cysteine S-palmitoyltransferase activity IEA--
         
    Find genes that share ontologies with ZDHHC11B           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Zdhhc11 (no phenotypes)

    Find genes that share phenotypes with ZDHHC11B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Zdhhc11tm1(KOMP)Vlcg for ZDHHC11B

       genOway: Develop your customized and physiologically relevant rodent model for ZDHHC11B

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZH11B_HUMAN, P0C7U3: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with ZDHHC11B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZDHHC11B
    Interactions:

        Search GeneGlobe Interaction Network for ZDHHC11B

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ZDHHC11B (ZH11B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000522356 ENST00000508859 ENST00000382776
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZDHHC11B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZDHHC11B Expression
    About this image

    ZDHHC11B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZDHHC11B Protein Expression
        Custom PCR Arrays for ZDHHC11B
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ZDHHC11B gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zdhhc115 zinc finger, DHHC domain containing 11   --   13 (40.15 cM) 73963862 
    zebrafish
    (Danio rerio)
    Actinopterygii CU694320.16
    Palmitoyltransferase
    32(a)
    1 → many
    16(56427392-56450152) ENSDARG00000076202
    fruit fly
    (Drosophila melanogaster)
    Insecta CG170756
    --
    11(a)
    1 → many
    2L(260379-267505)
    worm
    (Caenorhabditis elegans)
    Secernentea dhhc-116
    Protein DHHC-11 (dhhc-11) mRNA, complete cds
    20(a)
    1 → many
    I(5764030-5768190) WBGene00020694
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ERF26
    Subunit of a palmitoyltransferase, composed of Erf...
    15(a)
    1 → many
    XII(627118-628197) YLR246W


    ENSEMBL Gene Tree for ZDHHC11B (if available)
    TreeFam Gene Tree for ZDHHC11B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZDHHC11B gene
    ZDHHC12  ZDHHC142  ZDHHC112  ZDHHC52  ZDHHC42  ZDHHC82  ZDHHC192  ZDHHC92  
    ZDHHC182  
    4 SIMAP similar genes for ZDHHC11B using alignment to 2 protein entries:     ZH11B_HUMAN (see all proteins):
    ZDHHC11    ZDHHC1    ZDHHC5    ZDHHC18

    Find genes that share paralogs with ZDHHC11B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZDHHC11B (see all 1372)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1456640651,2
    C--720576(+) TCTTAC/GAGGAC 1 -- int10--------
    rs1394042811,2
    --720586(+) CATAAG/TAAATG 1 -- int10--------
    rs125229801,2
    C,H--720845(+) agaaaA/Gtcaga 1 -- int10--------
    rs96863191,2
    C--720971(+) tgggtC/Tgacaa 1 -- int10--------
    rs1484246541,2
    C--721044(+) ACCTCA/TAGGAC 1 -- int10--------
    rs1441236371,2
    C--721329(+) AGCAAA/C/GAAAAG 1 -- int10--------
    rs1464880271,2
    --721332(+) AAAAAA/GAGAAA 1 -- int10--------
    rs3811641,2
    C--721493(-) TCTAGT/GTGGGT 1 -- int11Minor allele frequency- G:0.00NA 2
    rs1899984301,2
    C--721523(+) AAACTC/TGTAAC 1 -- int10--------
    rs562391991,2
    C,F--721552(+) GAGATA/TGAAAC 1 -- int15Minor allele frequency- T:0.30NA WA 10

    HapMap Linkage Disequilibrium report for ZDHHC11B (710475 - 767067 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ZDHHC11B: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ZDHHC11B
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed article for ZDHHC11B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZDHHC11B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)1, 2 Schmutz J.... Rubin E.M. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 653082 HGNC: 32962 Ensembl:ENSG00000206077 euGenes: HUgn653082 ECgene: ZDHHC11B
    H-InvDB: ZDHHC11B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZDHHC11B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZDHHC11B gene:
    Search GeneIP for patents involving ZDHHC11B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     Browse ESI BIO Cell Lines and PureStem Progenitors for ZDHHC11B
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC11B
     Browse SwitchGear 3'UTR luciferase reporter plasmids for ZDHHC11B
     Browse SwitchGear Promoter luciferase reporter plasmids for ZDHHC11B
     Search ThermoFisher Antibodies for ZDHHC11B
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZDHHC11B
     Browse compounds at ApexBio
     Search Addgene for plasmids for ZDHHC11B
      Search eBioscience for proteins for ZDHHC11B
      Search eBioscience for elisas for ZDHHC11B
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for ZDHHC11B
     antibodies-online antibodies for ZDHHC11B
     antibodies-online kits for ZDHHC11B (2 products)
     antibodies-online peptides for ZDHHC11B
      Search antibodies-online for proteins for ZDHHC11B
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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