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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZDHHC11 Gene

protein-coding   GIFtS: 46
GCID: GC05M000720

Zinc Finger, DHHC-Type Containing 11

  Search for ZDHHC11
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger, DHHC-Type Containing 111 2     ZNF3992 3
Zinc Finger DHHC Domain-Containing Protein 112 3     Probable Palmitoyltransferase ZDHHC112
Zinc Finger Protein 3992 3     Zinc Finger, DHHC Domain Containing 112
DHHC-112 3     EC 2.3.1.-3

External Ids:    HGNC: 191581   Entrez Gene: 798442   Ensembl: ENSG000001888187   UniProtKB: Q9H8X93   

Export aliases for ZDHHC11 gene to outside databases

Previous GC identifers: GC05M000838 GC05M000848 GC05M000764 GC05M000715 GC05M000717 GC05M000718 GC05M000719


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZDHHC11 Gene: 
ZDHHC11 (zinc finger, DHHC-type containing 11) is a protein-coding gene. GO annotations related to this gene include transferase activity, transferring acyl groups and zinc ion binding. An important paralog of this gene is ZDHHC14.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_006576.16  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZDHHC11 gene promoter:
         AhR   NF-1   SREBP-1c   Pax-6   MyoD   HNF-3beta   SREBP-1b   Arnt   Zic1   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZDHHC11 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZDHHC11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZDHHC11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.33   Ensembl cytogenetic band:  5p15.33   HGNC cytogenetic band: 5p15.2

ZDHHC11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZDHHC11 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M000720:  view genomic region     (about GC identifiers)

Start:
710,471 bp from pter      End:
851,101 bp from pter
Size:
140,631 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZDH11_HUMAN, Q9H8X9 (See protein sequence)
Recommended Name: Probable palmitoyltransferase ZDHHC11  
Size: 412 amino acids; 45975 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Explore the universe of human proteins at neXtProt for ZDHHC11: NX_Q9H8X9

Explore proteomics data for ZDHHC11 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H8X9

  • ZDHHC11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZDHHC11 Protein Expression
    REFSEQ proteins: NP_079062.1  
    ENSEMBL proteins: 
     ENSP00000283441   ENSP00000423817   ENSP00000426873   ENSP00000427067   ENSP00000397719  

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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for ZDHHC11 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    ZDHHC11 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZDHHC: Zinc fingers, DHHC-type

    1 InterPro protein domain:
     IPR001594 Znf_DHHC_palmitoyltrfase

    Graphical View of Domain Structure for InterPro Entry Q9H8X9

    ProtoNet protein and cluster: Q9H8X9

    1 Blocks protein domain: IPB001594 Zn-finger

    UniProtKB/Swiss-Prot: ZDH11_HUMAN, Q9H8X9
    Domain: The DHHC domain is required for palmitoyltransferase activity (By similarity)
    Similarity: Belongs to the DHHC palmitoyltransferase family
    Similarity: Contains 1 DHHC-type zinc finger


    ZDHHC11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZDH11_HUMAN, Q9H8X9
    Catalytic activity: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA

         Enzyme Number (IUBMB): EC 2.3.1.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
    GO:0016746transferase activity, transferring acyl groups IEA--
         
    ZDHHC11 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZDHHC11:
     Lamellipodia cells 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZDHHC11 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZDHHC11

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZDHHC11 (ZDH11)

    Search CenterWatch for drugs/clinical trials and news about ZDHHC11 / ZDH11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZDHHC11 gene: 
    NM_024786.2  

    Unigene Cluster for ZDHHC11:

    Zinc finger, DHHC-type containing 11
    Hs.732788  [show with all ESTs]
    Unigene Representative Sequence: AK024233
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000503758(uc010itc.3 uc010itd.1) ENST00000283441(uc011cma.1)
    ENST00000507800 ENST00000508951 ENST00000511193 ENST00000511539(uc003jbk.3)
    ENST00000505815 ENST00000512190 ENST00000503880 ENST00000512775 ENST00000424784

    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZDHHC11
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZDHHC11
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    Additional mRNA sequence: 

    AK023215.1 AK024233.1 AY358673.1 BC032000.1 

    12 DOTS entries:

    DT.91699808  DT.425576  DT.40218666  DT.101971870  DT.40113433  DT.95310634  DT.100740984  DT.102831150 
    DT.120853991  DT.92009881  DT.120853990  DT.86855943 

    24/58 AceView cDNA sequences (see all 58):

    BU535704 BU538011 AY358673 BU428513 AA421803 CK000304 AU131881 CR605165 
    CA941804 AI379904 AA768200 NM_024786 CK023929 BX492248 BV196125 AA723382 
    BX116213 AA629842 BX953714 N78741 AL602302 BC032000 AK024233 BG677648 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC11 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^
    SP1:                                            -                       -     -                       -     -     -     -     -     -     -     -     -     -   
    SP2:                                                                    -     -                                                                                 
    SP3:                                -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                     
    SP4:                    -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -           -                     
    SP5:                                                                                                                                                            

    ExUns: 17 ^ 18 ^ 19 ^ 20
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for ZDHHC11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZDHHC11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGCTCACA
    ZDHHC11 Expression
    About this image


    See ZDHHC11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZDHHC11

    SOURCE GeneReport for Unigene cluster: Hs.732788
        SABiosciences Custom PCR Arrays for ZDHHC11
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ZDHHC11 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    zebrafish
    (Danio rerio)
    Actinopterygii CU694320.16
    Uncharacterized protein
    32(a)
    1 → many
    16(56427392-56450152)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG170756
    --
    10(a)
    1 → many
    2L(260379-267505)
    worm
    (Caenorhabditis elegans)
    Secernentea dhhc-116
    Protein T22E7.2
    19(a)
    1 → many
    I(5764030-5768190)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SWF16
    Palmitoyltransferase that acts on transmembrane pr...
    12(a)
    1 → many
    IV(703234-704244)
            Species with no ortholog for ZDHHC11

    ENSEMBL Gene Tree for ZDHHC11 (if available)
    TreeFam Gene Tree for ZDHHC11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZDHHC11 gene
    ZDHHC142  ZDHHC52  ZDHHC11B2  ZDHHC42  ZDHHC82  ZDHHC192  ZDHHC92  ZDHHC12  
    ZDHHC182  
    2 SIMAP similar genes for ZDHHC11 using alignment to 4 protein entries:     ZDH11_HUMAN (see all proteins):
    ZDHHC11B    ZDHHC1

    ZDHHC11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1679 SNPs in ZDHHC11 are shown (see all 1679)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3644071,2
    C--795256(-) AGCTCG/ACCTTG 1 -- int11Minor allele frequency- A:0.00NA 2
    rs602488211,2
    C--795257(+) AAGGCG/AAGCTG 1 -- int11Minor allele frequency- A:0.50WA 2
    rs4209951,2
    C--795259(-) TCCAGC/GTCGCC 1 -- int11Minor allele frequency- G:0.00NA 2
    rs4527791,2
    C--795298(-) AAGCTT/ATATCA 1 -- int11Minor allele frequency- A:0.00NA 2
    rs1891031961,2
    --795444(+) GTCCTC/TGCTCT 1 -- int10--------
    rs582753631,2
    C,F--795453(+) CTGGTG/AGTTCA 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1398780101,2
    --795486(+) ATGCAC/TGGTGC 1 -- int10--------
    rs1498345551,2
    --795534(+) ACTACA/GTGATG 1 -- int10--------
    rs24346291,2
    C,A,H--795557(-) TGAAGG/ATGGGG 1 -- int18Minor allele frequency- A:0.50NA WA EA 368
    rs1441661371,2
    --795706(+) AAACAC/TAAAAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZDHHC11 (710471 - 851101 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/80 variations for ZDHHC11 (see all 80):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv957e201CNV Deletion23290073
    esv2729359CNV Deletion23290073
    nsv436473CNV Deletion17901297
    dgv1002e199CNV Deletion23128226
    esv2660977CNV Deletion23128226
    esv2729364CNV Deletion23290073
    dgv1001e199CNV Deletion23128226
    dgv956e201CNV Deletion23290073
    nsv471431CNV Duplication19718026
    dgv18n31CNV Duplication19718026

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZDHHC11 for disorders           About MalaCards

    ZDHHC11 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZDHHC11
    Human Genome Epidemiology (HuGE) Navigator: ZDHHC11 (1 document)

    Export disorders for ZDHHC11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZDHHC11 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZDHHC11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Gain of 5p15.33 is associated with progression of bladder cancer. (PubMed id 18025801)1, 9 Yamamoto Y....Sasaki K. (2007)
    5. In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes. (PubMed id 23687301)1 Oku S....Fukata M. (2013)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1 Clark H.F.... Gray A.M. (2003)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79844 HGNC: 19158 AceView: ZDHHC11 Ensembl:ENSG00000188818 euGenes: HUgn79844
    ECgene: ZDHHC11 H-InvDB: ZDHHC11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZDHHC11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZDHHC11 gene:
    Search GeneIP for patents involving ZDHHC11

    GeneCards and IP:
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