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Aliases for ZDHHC11 Gene

Aliases for ZDHHC11 Gene

  • Zinc Finger DHHC-Type Containing 11 2 3
  • Zinc Finger DHHC Domain-Containing Protein 11 3 4
  • Zinc Finger, DHHC-Type Containing 11 3 5
  • Zinc Finger Protein 399 3 4
  • DHHC-11 3 4
  • ZNF399 3 4
  • Zinc Finger, DHHC Domain Containing 11 3
  • EC 2.3.1.225 4

External Ids for ZDHHC11 Gene

Previous GeneCards Identifiers for ZDHHC11 Gene

  • GC05M000838
  • GC05M000848
  • GC05M000764
  • GC05M000715
  • GC05M000717
  • GC05M000718
  • GC05M000719
  • GC05M000720
  • GC05M000721

Summaries for ZDHHC11 Gene

GeneCards Summary for ZDHHC11 Gene

ZDHHC11 (Zinc Finger DHHC-Type Containing 11) is a Protein Coding gene. GO annotations related to this gene include protein-cysteine S-palmitoyltransferase activity. An important paralog of this gene is ZDHHC4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC11 Gene

Genomics for ZDHHC11 Gene

Regulatory Elements for ZDHHC11 Gene

Genomic Location for ZDHHC11 Gene

Chromosome:
5
Start:
795,605 bp from pter
End:
858,973 bp from pter
Size:
63,369 bases
Orientation:
Minus strand

Genomic View for ZDHHC11 Gene

Genes around ZDHHC11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC11 Gene

Proteins for ZDHHC11 Gene

  • Protein details for ZDHHC11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8X9-ZDH11_HUMAN
    Recommended name:
    Probable palmitoyltransferase ZDHHC11
    Protein Accession:
    Q9H8X9
    Secondary Accessions:
    • Q6UWR9

    Protein attributes for ZDHHC11 Gene

    Size:
    412 amino acids
    Molecular mass:
    45975 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZDHHC11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZDHHC11 Gene

Proteomics data for ZDHHC11 Gene at MOPED

Post-translational modifications for ZDHHC11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZDHHC11 Gene

No data available for DME Specific Peptides for ZDHHC11 Gene

Domains & Families for ZDHHC11 Gene

Gene Families for ZDHHC11 Gene

Protein Domains for ZDHHC11 Gene

Suggested Antigen Peptide Sequences for ZDHHC11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H8X9

UniProtKB/Swiss-Prot:

ZDH11_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
  • Contains 1 DHHC-type zinc finger.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family.
Similarity:
  • Contains 1 DHHC-type zinc finger.
genes like me logo Genes that share domains with ZDHHC11: view

Function for ZDHHC11 Gene

Molecular function for ZDHHC11 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Enzyme Numbers (IUBMB) for ZDHHC11 Gene

genes like me logo Genes that share phenotypes with ZDHHC11: view

Animal Models for ZDHHC11 Gene

MGI Knock Outs for ZDHHC11:

Animal Model Products

  • Taconic Biosciences Mouse Models for ZDHHC11

miRNA for ZDHHC11 Gene

miRTarBase miRNAs that target ZDHHC11

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZDHHC11 Gene

Localization for ZDHHC11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC11 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZDHHC11 Gene COMPARTMENTS Subcellular localization image for ZDHHC11 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for ZDHHC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC11: view

Pathways & Interactions for ZDHHC11 Gene

SuperPathways for ZDHHC11 Gene

No Data Available

Interacting Proteins for ZDHHC11 Gene

Gene Ontology (GO) - Biological Process for ZDHHC11 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC11 Gene

Drugs & Compounds for ZDHHC11 Gene

(1) Drugs for ZDHHC11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for ZDHHC11 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
genes like me logo Genes that share compounds with ZDHHC11: view

Transcripts for ZDHHC11 Gene

Unigene Clusters for ZDHHC11 Gene

Zinc finger, DHHC-type containing 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC11 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^
SP1: - - - - - - - - - - - - -
SP2: - -
SP3: - - - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - - -
SP5:
SP6: - - - - - - - - - - - - - - - - -
SP7: -
SP8: - -
SP9:
SP10: - - -
SP11:
SP12:

ExUns: 17 ^ 18 ^ 19 ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for ZDHHC11 Gene

GeneLoc Exon Structure for
ZDHHC11
ECgene alternative splicing isoforms for
ZDHHC11

Expression for ZDHHC11 Gene

mRNA expression in normal human tissues for ZDHHC11 Gene

Protein differential expression in normal tissues from HIPED for ZDHHC11 Gene

This gene is overexpressed in Urine (39.3), Ovary (20.1), and Pancreatic juice (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZDHHC11 Gene



SOURCE GeneReport for Unigene cluster for ZDHHC11 Gene Hs.732788

genes like me logo Genes that share expression patterns with ZDHHC11: view

Protein tissue co-expression partners for ZDHHC11 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZDHHC11 Gene

Orthologs for ZDHHC11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 93 (a)
OneToMany
ZDHHC11 35
  • 97.37 (n)
  • 95.64 (a)
cow
(Bos Taurus)
Mammalia ZDHHC11 35
  • 67.47 (n)
  • 57.1 (a)
dog
(Canis familiaris)
Mammalia ZDHHC11 35
  • 64.78 (n)
  • 52.58 (a)
-- 36
  • 46 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zdhhc11 36
  • 52 (a)
OneToMany
Zdhhc11 16
Zdhhc11 35
  • 69.55 (n)
  • 60.55 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 48 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 53 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zdhhc11 35
  • 67.7 (n)
  • 59.66 (a)
zebrafish
(Danio rerio)
Actinopterygii CU694320.1 36
  • 33 (a)
OneToMany
LOC100334198 35
  • 54.73 (n)
  • 44.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17075 36
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dhhc-11 36
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERF2 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10560 36
  • 27 (a)
OneToMany
Species with no ortholog for ZDHHC11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZDHHC11 Gene

ENSEMBL:
Gene Tree for ZDHHC11 (if available)
TreeFam:
Gene Tree for ZDHHC11 (if available)

Paralogs for ZDHHC11 Gene

Paralogs for ZDHHC11 Gene

(2) SIMAP similar genes for ZDHHC11 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZDHHC11: view

Variants for ZDHHC11 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC11 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs3747738 - 819,556(-) CACTC(A/G)TGTAC nc-transcript-variant, reference, synonymous-codon, missense
rs1809008 - 825,165(+) TTACC(A/C/T)GTGCC nc-transcript-variant, reference, missense
rs2878468 - 825,213(-) GCACT(C/T)ATGTC nc-transcript-variant, reference, missense
rs377433 -- 838,148(-) GGGCT(A/G)CAGGG intron-variant, downstream-variant-500B
rs377460 -- 798,719(-) GTAGA(C/G)CACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC11 Gene

Variant ID Type Subtype PubMed ID
nsv880710 CNV Loss 21882294
dgv5884n71 CNV Gain 21882294
nsv881103 CNV Gain 21882294
nsv510933 CNV Complex 20534489
nsv525620 CNV Gain 19592680
dgv5n29 CNV Gain 16826518
nsv471627 CNV Gain+Loss 15918152
dgv1735e1 CNV Complex 17122850
dgv1736e1 CNV Complex 17122850
nsv428459 CNV Gain+Loss 18775914
dgv1737e1 CNV Complex 17122850
dgv5894n71 CNV Gain+Loss 21882294
nsv4675 CNV Loss 18451855
dgv195e55 CNV Gain 17911159
esv24225 CNV Gain+Loss 19812545
dgv5895n71 CNV Gain 21882294
esv33266 CNV Gain+Loss 17666407
nsv10654 CNV Gain+Loss 18304495
esv2729359 CNV Deletion 23290073
dgv1738e1 CNV Complex 17122850
dgv1739e1 CNV Complex 17122850
dgv1740e1 CNV Complex 17122850
dgv99e19 CNV Loss 19470904
dgv197e55 CNV Gain 17911159
dgv198e55 CNV Gain 17911159
nsv881456 CNV Gain+Loss 21882294
dgv5898n71 CNV Gain 21882294
dgv923n67 CNV Gain 20364138
dgv18n31 CNV Duplication 19718026
esv2752078 CNV Loss 17911159
nsv821639 CNV Gain 15273396
dgv924n67 CNV Gain 20364138
dgv5900n71 CNV Gain+Loss 21882294
nsv880898 CNV Loss 21882294
nsv822942 CNV Loss 20364138
dgv1742e1 CNV Complex 17122850
dgv1743e1 CNV Complex 17122850
dgv1744e1 CNV Complex 17122850
dgv1001e199 CNV Deletion 23128226
nsv469861 CNV Gain 16826518
dgv956e201 CNV Deletion 23290073
dgv5901n71 CNV Loss 21882294
nsv881502 CNV Loss 21882294
dgv5902n71 CNV Gain 21882294
dgv199e55 CNV Gain 17911159
nsv436886 CNV Insertion 17901297
dgv100e19 CNV Loss 19470904
dgv1002e199 CNV Deletion 23128226
dgv1745e1 CNV Complex 17122850
esv34916 CNV Gain 17911159
dgv5903n71 CNV Loss 21882294
nsv509043 CNV Insertion 20534489
dgv925n67 CNV Gain 20364138
dgv5904n71 CNV Gain 21882294
nsv881427 CNV Gain+Loss 21882294
nsv436473 CNV Deletion 17901297
nsv880488 CNV Gain 21882294
essv4334 CNV CNV 17122850
dgv957e201 CNV Deletion 23290073
nsv880580 CNV Gain+Loss 21882294
nsv881594 CNV Loss 21882294
nsv822947 CNV Gain 20364138
dgv5905n71 CNV Gain 21882294
dgv5906n71 CNV Gain 21882294
nsv471431 CNV Duplication 19718026
nsv514286 CNV Loss 21397061
dgv1746e1 CNV Complex 17122850
nsv822948 CNV Gain 20364138
nsv519464 CNV Loss 19592680
nsv818308 CNV Gain 17921354
dgv926n67 CNV Gain 20364138
nsv822951 CNV Gain 20364138
nsv441936 CNV CNV 18776908
esv2660977 CNV Deletion 23128226
nsv329774 CNV Insertion 16902084
esv2729364 CNV Deletion 23290073
nsv327579 CNV Loss 16902084
nsv330058 CNV Loss 16902084
esv33837 CNV Gain 17666407
nsv830186 CNV Gain 17160897

Variation tolerance for ZDHHC11 Gene

Residual Variation Intolerance Score: 97.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.11; 51.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZDHHC11 Gene

HapMap Linkage Disequilibrium report
ZDHHC11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC11 Gene

Disorders for ZDHHC11 Gene

Relevant External Links for ZDHHC11

Genetic Association Database (GAD)
ZDHHC11
Human Genome Epidemiology (HuGE) Navigator
ZDHHC11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZDHHC11

No disorders were found for ZDHHC11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC11 Gene

Publications for ZDHHC11 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Gain of 5p15.33 is associated with progression of bladder cancer. (PMID: 18025801) Yamamoto Y. … Sasaki K. (Oncology 2007) 3 23
  3. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. (PMID: 25086665) Wolpin B.M. … Amundadottir L.T. (Nat. Genet. 2014) 3
  4. In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes. (PMID: 23687301) Oku S. … Fukata M. (J. Biol. Chem. 2013) 3
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3

Products for ZDHHC11 Gene

Sources for ZDHHC11 Gene

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