Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZDHHC11 Gene

Aliases for ZDHHC11 Gene

  • Zinc Finger DHHC-Type Containing 11 2 3 5
  • Zinc Finger DHHC Domain-Containing Protein 11 3 4
  • Zinc Finger Protein 399 3 4
  • DHHC-11 3 4
  • ZNF399 3 4
  • Zinc Finger, DHHC Domain Containing 11 3
  • Probable Palmitoyltransferase ZDHHC11 3
  • EC 2.3.1.225 4

External Ids for ZDHHC11 Gene

Previous GeneCards Identifiers for ZDHHC11 Gene

  • GC05M000838
  • GC05M000848
  • GC05M000764
  • GC05M000715
  • GC05M000717
  • GC05M000718
  • GC05M000719
  • GC05M000720
  • GC05M000721

Summaries for ZDHHC11 Gene

GeneCards Summary for ZDHHC11 Gene

ZDHHC11 (Zinc Finger DHHC-Type Containing 11) is a Protein Coding gene. GO annotations related to this gene include protein-cysteine S-palmitoyltransferase activity. An important paralog of this gene is ZDHHC11B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC11 Gene

Genomics for ZDHHC11 Gene

Regulatory Elements for ZDHHC11 Gene

Enhancers for ZDHHC11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ZDHHC11 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZDHHC11 Gene

Chromosome:
5
Start:
795,605 bp from pter
End:
858,973 bp from pter
Size:
63,369 bases
Orientation:
Minus strand

Genomic View for ZDHHC11 Gene

Genes around ZDHHC11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC11 Gene

Proteins for ZDHHC11 Gene

  • Protein details for ZDHHC11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8X9-ZDH11_HUMAN
    Recommended name:
    Probable palmitoyltransferase ZDHHC11
    Protein Accession:
    Q9H8X9
    Secondary Accessions:
    • Q6UWR9

    Protein attributes for ZDHHC11 Gene

    Size:
    412 amino acids
    Molecular mass:
    45975 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZDHHC11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZDHHC11 Gene

Post-translational modifications for ZDHHC11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZDHHC11 Gene

No data available for DME Specific Peptides for ZDHHC11 Gene

Domains & Families for ZDHHC11 Gene

Gene Families for ZDHHC11 Gene

Protein Domains for ZDHHC11 Gene

Suggested Antigen Peptide Sequences for ZDHHC11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H8X9

UniProtKB/Swiss-Prot:

ZDH11_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
  • Contains 1 DHHC domain.
Family:
  • Belongs to the DHHC palmitoyltransferase family.
genes like me logo Genes that share domains with ZDHHC11: view

Function for ZDHHC11 Gene

Molecular function for ZDHHC11 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Enzyme Numbers (IUBMB) for ZDHHC11 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC11: view
genes like me logo Genes that share phenotypes with ZDHHC11: view

Animal Models for ZDHHC11 Gene

MGI Knock Outs for ZDHHC11:

Animal Model Products

  • Taconic Biosciences Mouse Models for ZDHHC11

CRISPR Products

miRNA for ZDHHC11 Gene

miRTarBase miRNAs that target ZDHHC11

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZDHHC11 Gene

Localization for ZDHHC11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC11 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZDHHC11 Gene COMPARTMENTS Subcellular localization image for ZDHHC11 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for ZDHHC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 16647879
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC11: view

Pathways & Interactions for ZDHHC11 Gene

SuperPathways for ZDHHC11 Gene

No Data Available

Interacting Proteins for ZDHHC11 Gene

Gene Ontology (GO) - Biological Process for ZDHHC11 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC11 Gene

Drugs & Compounds for ZDHHC11 Gene

(1) Drugs for ZDHHC11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for ZDHHC11 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
genes like me logo Genes that share compounds with ZDHHC11: view

Transcripts for ZDHHC11 Gene

Unigene Clusters for ZDHHC11 Gene

Zinc finger, DHHC-type containing 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC11 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^
SP1: - - - - - - - - - - - - -
SP2: - -
SP3: - - - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - - -
SP5:
SP6: - - - - - - - - - - - - - - - - -
SP7: -
SP8: - -
SP9:
SP10: - - -
SP11:
SP12:

ExUns: 17 ^ 18 ^ 19 ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for ZDHHC11 Gene

GeneLoc Exon Structure for
ZDHHC11
ECgene alternative splicing isoforms for
ZDHHC11

Expression for ZDHHC11 Gene

mRNA expression in normal human tissues for ZDHHC11 Gene

Protein differential expression in normal tissues from HIPED for ZDHHC11 Gene

This gene is overexpressed in Urine (39.3), Ovary (20.1), and Pancreatic juice (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZDHHC11 Gene



Protein tissue co-expression partners for ZDHHC11 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZDHHC11 Gene:

ZDHHC11

SOURCE GeneReport for Unigene cluster for ZDHHC11 Gene:

Hs.732788
genes like me logo Genes that share expression patterns with ZDHHC11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZDHHC11 Gene

Orthologs for ZDHHC11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZDHHC11 34
  • 67.47 (n)
  • 57.1 (a)
dog
(Canis familiaris)
Mammalia ZDHHC11 34
  • 64.78 (n)
  • 52.58 (a)
-- 35
  • 46 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zdhhc11 34
  • 69.55 (n)
  • 60.55 (a)
Zdhhc11 16
Zdhhc11 35
  • 52 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC11 34
  • 97.37 (n)
  • 95.64 (a)
-- 35
  • 93 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zdhhc11 34
  • 67.7 (n)
  • 59.66 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 48 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 53 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii LOC100334198 34
  • 54.73 (n)
  • 44.44 (a)
CU694320.1 35
  • 33 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17075 35
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dhhc-11 35
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERF2 35
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10560 35
  • 27 (a)
OneToMany
Species where no ortholog for ZDHHC11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZDHHC11 Gene

ENSEMBL:
Gene Tree for ZDHHC11 (if available)
TreeFam:
Gene Tree for ZDHHC11 (if available)

Paralogs for ZDHHC11 Gene

Paralogs for ZDHHC11 Gene

(2) SIMAP similar genes for ZDHHC11 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZDHHC11: view

Variants for ZDHHC11 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC11 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs3747738 - 819,556(-) CACTC(A/G)TGTAC nc-transcript-variant, reference, synonymous-codon, missense
rs1809008 - 825,165(+) TTACC(A/C/T)GTGCC nc-transcript-variant, reference, missense
rs2878468 - 825,213(-) GCACT(C/T)ATGTC nc-transcript-variant, reference, missense
rs170511 -- 845,580(-) TAAGA(G/T)AGGAA intron-variant
rs1573862 -- 803,095(-) GAAAT(C/T)GAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC11 Gene

Variant ID Type Subtype PubMed ID
dgv1001e199 CNV deletion 23128226
dgv1002e199 CNV deletion 23128226
dgv1063e214 CNV gain 21293372
dgv1064e214 CNV gain 21293372
dgv115e19 CNV loss 19470904
dgv116e19 CNV loss 19470904
dgv131e203 CNV gain+loss 21179565
dgv1560e212 CNV loss 25503493
dgv1561e212 CNV gain 25503493
dgv18n31 CNV gain 19718026
dgv195e55 CNV gain 17911159
dgv197e55 CNV gain 17911159
dgv198e55 CNV gain 17911159
dgv199e55 CNV gain 17911159
dgv206n111 CNV duplication 26073780
dgv207n111 CNV duplication 26073780
dgv3191e59 CNV duplication 20981092
dgv3192e59 CNV duplication 20981092
dgv3193e59 CNV duplication 20981092
dgv3194e59 CNV duplication 20981092
dgv345e215 CNV deletion 23714750
dgv5522n100 CNV gain 25217958
dgv5524n100 CNV gain 25217958
dgv5525n100 CNV gain 25217958
dgv5527n100 CNV gain+loss 25217958
dgv5531n100 CNV gain+loss 25217958
dgv5532n100 CNV loss 25217958
dgv5533n100 CNV gain+loss 25217958
dgv5534n100 CNV gain 25217958
dgv5535n100 CNV gain+loss 25217958
dgv5536n100 CNV gain 25217958
dgv5537n100 CNV loss 25217958
dgv5538n100 CNV gain 25217958
dgv5539n100 CNV gain 25217958
dgv5540n100 CNV loss 25217958
dgv5541n100 CNV gain+loss 25217958
dgv5542n100 CNV gain+loss 25217958
dgv5543n100 CNV loss 25217958
dgv5544n100 CNV loss 25217958
dgv5545n100 CNV loss 25217958
dgv5546n100 CNV gain 25217958
dgv5547n100 CNV gain+loss 25217958
dgv5548n100 CNV loss 25217958
dgv5549n100 CNV loss 25217958
dgv5550n100 CNV gain+loss 25217958
dgv5551n100 CNV gain 25217958
dgv7n29 CNV gain 16826518
dgv909e201 CNV deletion 23290073
dgv910e201 CNV deletion 23290073
dgv923n67 CNV gain 20364138
dgv924n67 CNV gain 20364138
dgv925n67 CNV gain 20364138
dgv926n67 CNV gain 20364138
dgv9498n54 CNV gain 21841781
dgv9499n54 CNV gain 21841781
dgv9512n54 CNV loss 21841781
dgv9513n54 CNV loss 21841781
dgv9514n54 CNV gain 21841781
dgv9515n54 CNV loss 21841781
dgv9516n54 CNV loss 21841781
esv24225 CNV gain+loss 19812545
esv2660977 CNV deletion 23128226
esv2729359 CNV deletion 23290073
esv2729364 CNV deletion 23290073
esv2752078 CNV loss 17911159
esv2759316 CNV gain+loss 17122850
esv3325793 CNV duplication 20981092
esv33266 CNV gain+loss 17666407
esv3332897 CNV duplication 20981092
esv3336574 CNV duplication 20981092
esv3357898 CNV duplication 20981092
esv3375918 CNV duplication 20981092
esv3383610 CNV duplication 20981092
esv33837 CNV gain 17666407
esv3399340 CNV duplication 20981092
esv3414923 CNV duplication 20981092
esv3450797 CNV duplication 20981092
esv34916 CNV gain 17911159
esv3565318 CNV deletion 23714750
esv3565322 CNV deletion 23714750
esv3575808 CNV gain 25503493
esv3603777 CNV loss 21293372
esv3603782 CNV loss 21293372
esv3894103 CNV loss 25118596
esv3894104 CNV loss 25118596
esv3894105 CNV gain+loss 25118596
esv3894107 CNV gain 25118596
nsv1019500 CNV loss 25217958
nsv1020000 CNV gain 25217958
nsv1020146 CNV gain+loss 25217958
nsv1031111 CNV gain+loss 25217958
nsv1032584 CNV gain 25217958
nsv10654 CNV gain+loss 18304495
nsv1073415 CNV deletion 25765185
nsv1078547 CNV duplication 25765185
nsv1110439 CNV duplication 24896259
nsv1118726 CNV duplication 24896259
nsv1126057 CNV deletion 24896259
nsv1128904 CNV duplication 24896259
nsv1130830 CNV deletion 24896259
nsv1132599 CNV duplication 24896259
nsv1133013 OTHER inversion 24896259
nsv1135950 CNV deletion 24896259
nsv1141469 CNV duplication 24896259
nsv1142629 CNV deletion 24896259
nsv1147234 OTHER inversion 26484159
nsv1147571 CNV duplication 26484159
nsv1147755 CNV duplication 26484159
nsv1161198 CNV duplication 26073780
nsv1161200 OTHER complex 26073780
nsv1161207 CNV deletion 26073780
nsv327579 CNV deletion 16902084
nsv329774 CNV insertion 16902084
nsv330058 CNV deletion 16902084
nsv428459 CNV gain+loss 18775914
nsv436473 CNV deletion 17901297
nsv436886 CNV insertion 17901297
nsv441936 CNV gain 18776908
nsv4675 CNV deletion 18451855
nsv469861 CNV gain 16826518
nsv471431 CNV gain 19718026
nsv471627 CNV gain+loss 15918152
nsv509043 CNV insertion 20534489
nsv510933 OTHER complex 20534489
nsv514286 CNV loss 21397061
nsv519464 CNV loss 19592680
nsv525620 CNV gain 19592680
nsv596629 CNV gain 21841781
nsv596711 CNV gain 21841781
nsv596714 CNV gain 21841781
nsv596741 CNV gain+loss 21841781
nsv596742 CNV gain 21841781
nsv596777 CNV gain 21841781
nsv596780 CNV loss 21841781
nsv818308 CNV gain 17921354
nsv821639 CNV gain 15273396
nsv822942 CNV loss 20364138
nsv822947 CNV gain 20364138
nsv822948 CNV gain 20364138
nsv822951 CNV gain 20364138
nsv830186 CNV gain 17160897
nsv950626 CNV duplication 24416366
nsv968133 CNV duplication 23825009
nsv968134 CNV duplication 23825009
nsv968866 CNV duplication 23825009
nsv968867 CNV duplication 23825009
nsv981008 CNV duplication 23825009

Variation tolerance for ZDHHC11 Gene

Residual Variation Intolerance Score: 97.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.11; 51.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZDHHC11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZDHHC11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC11 Gene

Disorders for ZDHHC11 Gene

Relevant External Links for ZDHHC11

Genetic Association Database (GAD)
ZDHHC11
Human Genome Epidemiology (HuGE) Navigator
ZDHHC11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZDHHC11

No disorders were found for ZDHHC11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC11 Gene

Publications for ZDHHC11 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  2. Gain of 5p15.33 is associated with progression of bladder cancer. (PMID: 18025801) Yamamoto Y. … Sasaki K. (Oncology 2007) 3 22 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 65

Products for ZDHHC11 Gene

Sources for ZDHHC11 Gene

Content