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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZDHHC1 Gene

protein-coding   GIFtS: 47
GCID: GC16M067428

zinc finger, DHHC-type containing 1

(Previous name: chromosome 16 open reading frame 1 )
(Previous symbol: C16orf1)
 Explore 1 disease affiliated with
ZDHHC1 via our new
 Human Malady Compendium 
Biological research products
for ZDHHC1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger, DHHC-Type Containing 11 2     DHHC Domain-Containing Cysteine-Rich Protein 12 3
C16orf11 2 3     Chromosome 16 Open Reading Frame 11
ZNF3771 2 3     DHHC-Domain-Containing Cysteine-Rich Protein2
HSU906531 2     Probable Palmitoyltransferase ZDHHC12
Zinc Finger DHHC Domain-Containing Protein 12 3     Zinc Finger, DHHC Domain Containing 12
Zinc Finger Protein 3772 3     EC 2.3.1.-3
DHHC-12 3     

External Ids:    HGNC: 179161   Entrez Gene: 298002   Ensembl: ENSG000001597147   UniProtKB: Q8WTX93   

Export aliases for ZDHHC1 gene to outside databases

Previous GC identifers: GC16M058122 GC16M067806 GC16M067163 GC16M067204 GC16M065985 GC16M053301


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZDHHC1 gene promoter:
         SRY   Sp1   Olf-1   HNF-4alpha2   CUTL1   HNF-4alpha1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZDHHC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZDHHC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZDHHC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

ZDHHC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZDHHC1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M067428:  view genomic region     (about GC identifiers)

Start:
67,428,322 bp from pter      End:
67,450,736 bp from pter
Size:
22,415 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZDHC1_HUMAN, Q8WTX9 (See protein sequence)
Recommended Name: Probable palmitoyltransferase ZDHHC1  
Size: 485 amino acids; 54818 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: O15461

Explore the universe of human proteins at neXtProt for ZDHHC1: NX_Q8WTX9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8WTX9

  • ZDHHC1 Protein expression data from MOPED and PaxDb:    About this image 
    ZDHHC1 Protein Expression
    REFSEQ proteins: NP_037436.1  
    ENSEMBL proteins: 
     ENSP00000340299   ENSP00000459264  

    Human Recombinant Protein Products for ZDHHC1: 
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    Uscn Proteins for ZDHHC1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0016021integral to membrane IEA--

    ZDHHC1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZDHHC1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001594 Znf_DHHC_palmitoyltrfase

    Graphical View of Domain Structure for InterPro Entry Q8WTX9

    ProtoNet protein and cluster: Q8WTX9

    1 Blocks protein family: IPB001594 Zn-finger

    UniProtKB/Swiss-Prot: ZDHC1_HUMAN, Q8WTX9
    Domain: The DHHC domain is required for palmitoyltransferase activity (By similarity)
    Similarity: Belongs to the DHHC palmitoyltransferase family
    Similarity: Contains 1 DHHC-type zinc finger


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZDHC1_HUMAN, Q8WTX9
    Catalytic activity: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA

         Enzyme Number (IUBMB): EC 2.3.1.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS10395086
    GO:0008270zinc ion binding IEA--
    GO:0016409palmitoyltransferase activity IEA--
         
    ZDHHC1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ZDHHC1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZDHHC1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZDHHC1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZDHHC1 (ENSP000003402994) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0018345protein palmitoylation IEA--

    ZDHHC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZDHHC1
    Search CenterWatch for drugs/clinical trials and news about ZDHHC1 / ZDHC1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZDHHC1 gene: 
    NM_013304.2  

    Unigene Clusters for ZDHHC1:

    Zinc finger, DHHC-type containing 1
    Hs.624541 , Hs.658333  [show with all ESTs]
    Unigene Representative Sequences: BC045169, BC021908
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000348579(uc010vjm.2) ENST00000566075 ENST00000565726 ENST00000562122
    ENST00000567311 ENST00000568650

    miRNA
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    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate ZDHHC1 (see all 16):
    hsa-miR-448 hsa-miR-137 hsa-miR-106a hsa-miR-519a hsa-miR-93 hsa-miR-526b* hsa-miR-17 hsa-miR-20a
    SwitchGear 3'UTR luciferase reporter plasmidZDHHC1 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AK307155.1 BC021908.1 U90653.2 

    9 DOTS entries:

    DT.40223486  DT.100749881  DT.435563  DT.75100369  DT.97840105  DT.101975372  DT.92017098  DT.95292785 
    DT.97767695 

    24/283 AceView cDNA sequences (see all 283):

    AI684017 CB960154 AI672689 BM977604 AI683176 BC021908 BX339720 AA330354 
    F21667 CR626572 BU740451 BQ021936 BU684514 AW183430 CD110326 BM818430 
    AI369028 CR593543 BI754230 AI955395 CR590764 AW149915 AI800838 BM739156 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC1 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b
    SP1:                          -     -                 -                                         -                                 
    SP2:                                                                                                                              
    SP3:                                                                                                                              
    SP4:                                                                                                                              
    SP5:        -                                                                                                                     


    ECgene alternative splicing isoforms for ZDHHC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZDHHC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CGGACCTTCA
    ZDHHC1 Expression
    About this image
    See ZDHHC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZDHHC1

    SOURCE GeneReport for Unigene clusters: Hs.624541 Hs.658333

    UniProtKB/Swiss-Prot: ZDHC1_HUMAN, Q8WTX9
    Tissue specificity: Expressed at high levels in fetal lung, kidney and heart. Expressed at lower levels in adult
    pancreas and lung

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ZDHHC1 gene from 7/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ZDHHC11 zinc finger, DHHC-type containing 1 66.47(n)
    64.16(a)
      769748  XM_001233038.2  XP_001233039.2 
    lizard
    (Anolis carolinensis)
    Reptilia ZDHHC16
    --
    49(a)
    1 ↔ 1
    GL343295.1(327794-339290)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5626141 probable palmitoyltransferase ZDHHC1-like 62.19(n)
    61.02(a)
      562614  XM_685994.5  XP_691086.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG170756
    --
    12(a)
    1 → many
    2L(260379-267505)
    worm
    (Caenorhabditis elegans)
    Secernentea T22E7.26
    Protein T22E7.2
    20(a)
    1 → many
    I(5764033-5768193)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G336406
    AT4G017306
    (see all 5)
    DHHC-type zinc finger protein
    (see all 5)
    17(a)
    16(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    2(14239213-14242365)
    4(749574-752034)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 6)
    zinc finger family protein, putative, expressed
    (see all 6)
    16(a)
    15(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    12(9271501-9274409)
    4(29371734-29378114)


    ENSEMBL Gene Tree for ZDHHC1 (if available)
    TreeFam Gene Tree for ZDHHC1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZDHHC1 gene
    ZDHHC112  ZDHHC42  ZDHHC11B2  
    7 SIMAP similar genes for ZDHHC1 using alignment to 2 protein entries:     ZDHC1_HUMAN (see all proteins):
    ZDHHC11    ZDHHC2    ZDHHC11B    ZDHHC3    ZDHHC5    ZDHHC7
    ZDHHC18

    ZDHHC1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZDHHC1
    PGOHUM00000238317


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/302 NCBI SNPs in ZDHHC1 are shown (see all 302    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs99221911,2
    C,A,H--67427825(+) CAAGAG/CCACTG 3 -- us2k1 int16Minor allele frequency- C:0.05NS EA WA 534
    rs785589681,2
    --67427892(+) GATTCA/GGAGCC 3 -- int1 us2k13Minor allele frequency- G:0.11CSA WA NA 239
    rs1417132931,2
    --67427975(+) TTCGAC/TGGCAG 3 -- int1 us2k10--------
    rs1453485471,2
    --67428096(+) AGCCTA/GCTTTC 3 -- us2k1 int10--------
    rs1171327861,2
    --67428307(+) TTAAGA/GAAGTA 3 -- int1 us2k11Minor allele frequency- G:0.01NA 120
    rs1884045701,2
    --67428637(+) GGGCGC/GCCAGA 4 P A us2k1 mis10--------
    rs1930122531,2
    --67428882(+) CAGGAA/CCCGGA 3 -- us2k1 int10--------
    rs1455817131,2
    F--67429034(+) GGTAGA/TGGCTT 4 P syn1 us2k11Minor allele frequency- T:0.00NA 4364
    rs1835494581,2
    --67429081(+) ACAGTC/TCCTCC 4 N D us2k1 mis10--------
    rs2007240001,2
    --67429093(+) ACCTGG/TGGTCG 4 T P us2k1 mis10--------

    HapMap Linkage Disequilibrium report for ZDHHC1 (67428322 - 67450736 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ZDHHC1
         1 CNV: 77386

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZDHHC1 for disorders           About GeneDecksing

    1 disease for ZDHHC1:    About MalaCards
    malaria

    Human Genome Epidemiology (HuGE) Navigator: ZDHHC1 (1 document)

    Export disorders for ZDHHC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZDHHC1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZDHHC1)
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    1. The DHHC domain: a new highly conserved cysteine-rich motif. (PubMed id 10395086)1, 2, 3 Putilina T.... Gentleman S. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    4. Genome-wide searching of rare genetic variants in WTC CC data. (PubMed id 20549515)1 Feng T. and Zhu X. (2010)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. (PubMed id 16647879)9 Ohno Y....Igarashi Y. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29800 HGNC: 17916 AceView: ZDHHC1andCGI-38 Ensembl:ENSG00000159714 euGenes: HUgn29800
    ECgene: ZDHHC1 H-InvDB: ZDHHC1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZDHHC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZDHHC1 gene:
    Search GeneIP for patents involving ZDHHC1

    GeneCards and IP:
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