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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZDHHC1 Gene

protein-coding   GIFtS: 47
GCID: GC16M067428

Zinc Finger, DHHC-Type Containing 1

(Previous name: chromosome 16 open reading frame 1)
(Previous symbol: C16orf1)
  Search for ZDHHC1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger, DHHC-Type Containing 11 2     Chromosome 16 Open Reading Frame 11
C16orf11 2 3     HSU906532
Zinc Finger DHHC Domain-Containing Protein 12 3     DHHC-Domain-Containing Cysteine-Rich Protein2
Zinc Finger Protein 3772 3     Probable Palmitoyltransferase ZDHHC12
DHHC-12 3     Zinc Finger, DHHC Domain Containing 12
ZNF3772 3     EC 2.3.1.-3
DHHC Domain-Containing Cysteine-Rich Protein 12 3     

External Ids:    HGNC: 179161   Entrez Gene: 298002   Ensembl: ENSG000001597147   UniProtKB: Q8WTX93   

Export aliases for ZDHHC1 gene to outside databases

Previous GC identifers: GC16M058122 GC16M067806 GC16M067163 GC16M067204 GC16M065985 GC16M053301


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZDHHC1 Gene: 
ZDHHC1 (zinc finger, DHHC-type containing 1) is a protein-coding gene. GO annotations related to this gene include palmitoyltransferase activity and DNA binding. An important paralog of this gene is ZDHHC14.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZDHHC1 gene promoter:
         SRY   Sp1   Olf-1   HNF-4alpha2   CUTL1   HNF-4alpha1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZDHHC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZDHHC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZDHHC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

ZDHHC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZDHHC1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M067428:  view genomic region     (about GC identifiers)

Start:
67,428,322 bp from pter      End:
67,450,736 bp from pter
Size:
22,415 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZDHC1_HUMAN, Q8WTX9 (See protein sequence)
Recommended Name: Probable palmitoyltransferase ZDHHC1  
Size: 485 amino acids; 54818 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: O15461

Explore the universe of human proteins at neXtProt for ZDHHC1: NX_Q8WTX9

Explore proteomics data for ZDHHC1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WTX9

  • ZDHHC1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZDHHC1 Protein Expression
    REFSEQ proteins: NP_037436.1  
    ENSEMBL proteins: 
     ENSP00000340299   ENSP00000459264  

    Human Recombinant Protein Products for ZDHHC1: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0016021integral to membrane IEA--

    ZDHHC1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZDHHC: Zinc fingers, DHHC-type

    1 InterPro protein domain:
     IPR001594 Znf_DHHC_palmitoyltrfase

    Graphical View of Domain Structure for InterPro Entry Q8WTX9

    ProtoNet protein and cluster: Q8WTX9

    1 Blocks protein domain: IPB001594 Zn-finger

    UniProtKB/Swiss-Prot: ZDHC1_HUMAN, Q8WTX9
    Domain: The DHHC domain is required for palmitoyltransferase activity (By similarity)
    Similarity: Belongs to the DHHC palmitoyltransferase family
    Similarity: Contains 1 DHHC-type zinc finger


    ZDHHC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZDHC1_HUMAN, Q8WTX9
    Catalytic activity: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA

         Enzyme Number (IUBMB): EC 2.3.1.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS10395086
    GO:0008270zinc ion binding IEA--
    GO:0016409palmitoyltransferase activity IEA--
         
    ZDHHC1 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZDHHC1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZDHHC1 (ENSP000003402994) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0018345protein palmitoylation IEA--

    ZDHHC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZDHHC1 (ZDHC1)

    Search CenterWatch for drugs/clinical trials and news about ZDHHC1 / ZDHC1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZDHHC1 gene: 
    NM_013304.2  

    Unigene Clusters for ZDHHC1:

    Zinc finger, DHHC-type containing 1
    Hs.624541 , Hs.658333  [show with all ESTs]
    Unigene Representative Sequences: BC045169, BC021908
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000348579(uc010vjm.2) ENST00000566075 ENST00000565726 ENST00000562122
    ENST00000567311 ENST00000568650
    miRNA
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    hsa-miR-448 hsa-miR-137 hsa-miR-106a hsa-miR-519a hsa-miR-93 hsa-miR-526b* hsa-miR-17 hsa-miR-20a
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK307155.1 BC021908.1 U90653.2 

    9 DOTS entries:

    DT.40223486  DT.100749881  DT.435563  DT.75100369  DT.97840105  DT.101975372  DT.92017098  DT.95292785 
    DT.97767695 

    24/283 AceView cDNA sequences (see all 283):

    CR622352 BC021908 AI418500 BM977604 AI700172 BM721377 BQ021936 CD110326 
    BM699006 BE257080 AI672689 AW149915 AW087326 AI686361 CR626572 AI688738 
    U90653 CR612698 BE390737 BQ721629 BI754230 BM818430 AI955395 AI247537 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC1 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b
    SP1:                          -     -                 -                                         -                                 
    SP2:                                                                                                                              
    SP3:                                                                                                                              
    SP4:                                                                                                                              
    SP5:        -                                                                                                                     


    ECgene alternative splicing isoforms for ZDHHC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZDHHC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGACCTTCA
    ZDHHC1 Expression
    About this image


    See ZDHHC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZDHHC1

    SOURCE GeneReport for Unigene clusters: Hs.624541 Hs.658333

    UniProtKB/Swiss-Prot: ZDHC1_HUMAN, Q8WTX9
    Tissue specificity: Expressed at high levels in fetal lung, kidney and heart. Expressed at lower levels in adult
    pancreas and lung

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ZDHHC1 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zdhhc11 , 5 zinc finger, DHHC domain containing 11, 5 85.22(n)1
    88.15(a)1
      8 (53.04 cM)5
    707961  NM_175160.31  NP_780369.11 
     1054724815 
    chicken
    (Gallus gallus)
    Aves ZDHHC11 zinc finger, DHHC-type containing 1 66.47(n)
    64.16(a)
      769748  XM_001233038.2  XP_001233039.2 
    lizard
    (Anolis carolinensis)
    Reptilia ZDHHC16
    Uncharacterized protein
    49(a)
    1 ↔ 1
    GL343295.1(327794-341604)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5626141 probable palmitoyltransferase ZDHHC1-like 62.19(n)
    61.02(a)
      562614  XM_685994.5  XP_691086.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG170756
    --
    13(a)
    1 → many
    2L(260379-267505)
    worm
    (Caenorhabditis elegans)
    Secernentea dhhc-116
    Protein T22E7.2
    21(a)
    1 → many
    I(5764030-5768190)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SWF16
    Palmitoyltransferase that acts on transmembrane pr...
    11(a)
    1 → many
    IV(703234-704244)


    ENSEMBL Gene Tree for ZDHHC1 (if available)
    TreeFam Gene Tree for ZDHHC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZDHHC1 gene
    ZDHHC142  ZDHHC112  ZDHHC52  ZDHHC11B2  ZDHHC42  ZDHHC82  ZDHHC192  ZDHHC92  
    ZDHHC182  
    7 SIMAP similar genes for ZDHHC1 using alignment to 2 protein entries:     ZDHC1_HUMAN (see all proteins):
    ZDHHC11    ZDHHC2    ZDHHC11B    ZDHHC3    ZDHHC5    ZDHHC7
    ZDHHC18

    ZDHHC1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZDHHC1
    PGOHUM00000238317


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/386 SNPs in ZDHHC1 are shown (see all 386)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs71913181,2
    C,F,H--67429595(+) AGGCTC/ACCAGC 1 -- int119Minor allele frequency- A:0.35NS EA NA WA CSA 1850
    rs1494834291,2
    --67429779(+) AGCTCA/GGAGCT 1 -- int10--------
    rs1438889731,2
    C--67429789(+) TGCCCA/GCACCT 1 -- int10--------
    rs71922431,2
    C,F,A,H--67429922(+) ACAGAG/CGACCA 1 -- int18Minor allele frequency- C:0.19NS EA NA WA 540
    rs1878566181,2
    --67429977(+) CGGTGC/GTCTCC 1 -- int10--------
    rs1473190191,2
    --67430326(+) TGTCGC/TCAGTT 1 -- int10--------
    rs1915592291,2
    --67430605(+) GCGGGA/GTCAGG 1 -- int10--------
    rs1836987311,2
    --67431015(+) CCCCCA/GGGTTT 1 -- int10--------
    rs1893395131,2
    --67431178(+) CTTCTC/TTGGGC 1 -- int10--------
    rs1409266851,2
    --67431187(+) GCCTCC/TGTCTC 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZDHHC1 (67428322 - 67450736 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ZDHHC1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv906806CNV Loss21882294
    nsv524363CNV Loss19592680
    nsv833266CNV Loss17160897
    nsv827710CNV Gain20364138
    nsv471092CNV Gain18288195
    nsv522852CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZDHHC1 for disorders           About MalaCards

    ZDHHC1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZDHHC1
    Human Genome Epidemiology (HuGE) Navigator: ZDHHC1 (1 document)

    Export disorders for ZDHHC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZDHHC1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZDHHC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DHHC domain: a new highly conserved cysteine-rich motif. (PubMed id 10395086)1, 2, 3 Putilina T.... Gentleman S. (1999)
    2. Genome-wide searching of rare genetic variants in WTC CC data. (PubMed id 20549515)1, 4 Feng T. and Zhu X. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes. (PubMed id 23687301)1 Oku S....Fukata M. (2013)
    5. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. (PubMed id 16647879)9 Ohno Y....Igarashi Y. (2006)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29800 HGNC: 17916 AceView: ZDHHC1andCGI-38 Ensembl:ENSG00000159714 euGenes: HUgn29800
    ECgene: ZDHHC1 H-InvDB: ZDHHC1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for ZDHHC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for ZDHHC1 gene:
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