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Aliases for ZDHHC1 Gene

Aliases for ZDHHC1 Gene

  • Zinc Finger, DHHC-Type Containing 1 2 3
  • DHHC Domain-Containing Cysteine-Rich Protein 1 3 4
  • Zinc Finger DHHC Domain-Containing Protein 1 3 4
  • Zinc Finger Protein 377 3 4
  • C16orf1 3 4
  • DHHC-1 3 4
  • ZNF377 3 4
  • DHHC-Domain-Containing Cysteine-Rich Protein 3
  • Zinc Finger, DHHC Domain Containing 1 3
  • Probable Palmitoyltransferase ZDHHC1 3
  • Chromosome 16 Open Reading Frame 1 2
  • EC 4
  • HSU90653 3
  • ZDHHC15 6
  • MRX91 6

External Ids for ZDHHC1 Gene

Previous HGNC Symbols for ZDHHC1 Gene

  • C16orf1

Previous GeneCards Identifiers for ZDHHC1 Gene

  • GC16M058122
  • GC16M067806
  • GC16M067163
  • GC16M067204
  • GC16M065985
  • GC16M053301

Summaries for ZDHHC1 Gene

GeneCards Summary for ZDHHC1 Gene

ZDHHC1 (Zinc Finger, DHHC-Type Containing 1) is a Protein Coding gene. GO annotations related to this gene include palmitoyltransferase activity. An important paralog of this gene is ZDHHC4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC1 Gene

Genomics for ZDHHC1 Gene

Regulatory Elements for ZDHHC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZDHHC1 Gene

67,394,419 bp from pter
67,416,833 bp from pter
22,415 bases
Minus strand

Genomic View for ZDHHC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZDHHC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC1 Gene

Proteins for ZDHHC1 Gene

  • Protein details for ZDHHC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable palmitoyltransferase ZDHHC1
    Protein Accession:
    Secondary Accessions:
    • O15461

    Protein attributes for ZDHHC1 Gene

    485 amino acids
    Molecular mass:
    54818 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZDHHC1 Gene

Proteomics data for ZDHHC1 Gene at MOPED

Post-translational modifications for ZDHHC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZDHHC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZDHHC1 Gene

Domains for ZDHHC1 Gene

Gene Families for ZDHHC1 Gene

  • ZDHHC :Zinc fingers, DHHC-type

Protein Domains for ZDHHC1 Gene

Suggested Antigen Peptide Sequences for ZDHHC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8WTX9
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
  • Contains 1 DHHC-type zinc finger.
genes like me logo Genes that share domains with ZDHHC1: view

Function for ZDHHC1 Gene

Molecular function for ZDHHC1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA

Enzyme Numbers (IUBMB) for ZDHHC1 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 10395086
GO:0008270 zinc ion binding IEA --
GO:0016409 palmitoyltransferase activity IDA 23034182
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC1: view

Animal Model Products

miRNA for ZDHHC1 Gene

miRTarBase miRNAs that target ZDHHC1

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZDHHC1 Gene

Localization for ZDHHC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ZDHHC1 Gene COMPARTMENTS Subcellular localization image for ZDHHC1 gene
Compartment Confidence
plasma membrane 2
cytosol 1

Gene Ontology (GO) - Cellular Components for ZDHHC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 16647879
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ZDHHC1: view

Pathways for ZDHHC1 Gene

SuperPathways for ZDHHC1 Gene

No Data Available

Interacting Proteins for ZDHHC1 Gene

Gene Ontology (GO) - Biological Process for ZDHHC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0018345 protein palmitoylation IDA 23034182
genes like me logo Genes that share ontologies with ZDHHC1: view

No data available for Pathways by source for ZDHHC1 Gene

Transcripts for ZDHHC1 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZDHHC1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b
SP1: - - - -
SP5: -
SP6: -

Relevant External Links for ZDHHC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZDHHC1 Gene

mRNA expression in normal human tissues for ZDHHC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ZDHHC1 Gene

This gene is overexpressed in Placenta (60.3) and Urine (8.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZDHHC1 Gene

SOURCE GeneReport for Unigene cluster for ZDHHC1 Gene Hs.624541

mRNA Expression by UniProt/SwissProt for ZDHHC1 Gene

Tissue specificity: Expressed at high levels in fetal lung, kidney and heart. Expressed at lower levels in adult pancreas and lung.
genes like me logo Genes that share expressions with ZDHHC1: view

Expression partners for ZDHHC1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ZDHHC1 Gene

Orthologs for ZDHHC1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia ZDHHC1 35
  • 88.77 (n)
  • 87.66 (a)
  • 73 (a)
(Mus musculus)
Mammalia Zdhhc1 35
  • 85.22 (n)
  • 88.15 (a)
Zdhhc1 16
Zdhhc1 36
  • 71 (a)
(Pan troglodytes)
Mammalia ZDHHC1 35
  • 99.66 (n)
  • 99.59 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Zdhhc1 35
  • 84.66 (n)
  • 88.43 (a)
(Bos Taurus)
Mammalia ZDHHC1 36
  • 75 (a)
(Monodelphis domestica)
Mammalia ZDHHC1 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 77 (a)
-- 36
  • 79 (a)
(Gallus gallus)
Aves ZDHHC1 35
  • 63.25 (n)
  • 59.84 (a)
  • 46 (a)
(Anolis carolinensis)
Reptilia ZDHHC1 36
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc1 35
  • 60.6 (n)
  • 58.61 (a)
(Danio rerio)
Actinopterygii LOC562614 35
  • 63.02 (n)
  • 61.74 (a)
  • 38 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17075 36
  • 15 (a)
(Caenorhabditis elegans)
Secernentea dhhc-11 36
  • 22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERF2 36
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10560 36
  • 30 (a)
Species with no ortholog for ZDHHC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC1 Gene

Gene Tree for ZDHHC1 (if available)
Gene Tree for ZDHHC1 (if available)

Paralogs for ZDHHC1 Gene

Selected SIMAP similar genes for ZDHHC1 Gene using alignment to 2 proteins: Pseudogenes for ZDHHC1 Gene

genes like me logo Genes that share paralogs with ZDHHC1: view

Variants for ZDHHC1 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs874469 -- 67,407,859(+) ATCCT(A/G)GTCCA intron-variant, upstream-variant-2KB
rs1055601 -- 67,413,224(-) tttac(A/G)cctgt intron-variant
rs1559323 -- 67,413,352(-) CTTTA(C/G)GTAGT intron-variant
rs2059237 -- 67,402,955(-) TTAAC(C/T)CATTA intron-variant
rs4783589 -- 67,413,720(+) agatc(A/C)cctga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC1 Gene

Variant ID Type Subtype PubMed ID
nsv524363 CNV Loss 19592680
nsv522852 CNV Gain 19592680
nsv471092 CNV Gain 18288195
nsv906806 CNV Loss 21882294
nsv833266 CNV Loss 17160897
nsv827710 CNV Gain 20364138

Relevant External Links for ZDHHC1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC1 Gene

Disorders for ZDHHC1 Gene

(1) OMIM Diseases for ZDHHC1 Gene (300576)

Relevant External Links for ZDHHC1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for ZDHHC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ZDHHC1 Gene

Publications for ZDHHC1 Gene

  1. The DHHC domain: a new highly conserved cysteine-rich motif. (PMID: 10395086) Putilina T. … Gentleman S. (Mol. Cell. Biochem. 1999) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genome-wide searching of rare genetic variants in WTCCC data. (PMID: 20549515) Feng T. … Zhu X. (Hum. Genet. 2010) 3 48
  4. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. (PMID: 16647879) Ohno Y. … Igarashi Y. (Biochim. Biophys. Acta 2006) 3 23
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for ZDHHC1 Gene

Sources for ZDHHC1 Gene

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