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Aliases for ZDBF2 Gene

Aliases for ZDBF2 Gene

  • Zinc Finger, DBF-Type Containing 2 2 3
  • KIAA1571 4

External Ids for ZDBF2 Gene

Previous GeneCards Identifiers for ZDBF2 Gene

  • GC02P206848
  • GC02P207139
  • GC02P198990

Summaries for ZDBF2 Gene

GeneCards Summary for ZDBF2 Gene

ZDBF2 (Zinc Finger, DBF-Type Containing 2) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDBF2 Gene

Genomics for ZDBF2 Gene

Regulatory Elements for ZDBF2 Gene

Genomic Location for ZDBF2 Gene

Start:
206,274,641 bp from pter
End:
206,314,438 bp from pter
Size:
39,798 bases
Orientation:
Plus strand

Genomic View for ZDBF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZDBF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDBF2 Gene

Proteins for ZDBF2 Gene

  • Protein details for ZDBF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCK1-ZDBF2_HUMAN
    Recommended name:
    DBF4-type zinc finger-containing protein 2
    Protein Accession:
    Q9HCK1
    Secondary Accessions:
    • Q6ZNP7
    • Q6ZSN8

    Protein attributes for ZDBF2 Gene

    Size:
    2354 amino acids
    Molecular mass:
    265618 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85454.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZDBF2 Gene

Proteomics data for ZDBF2 Gene at MOPED

Post-translational modifications for ZDBF2 Gene

  • Ubiquitination at Lys2133
  • Modification sites at PhosphoSitePlus

Other Protein References for ZDBF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZDBF2 Gene

Domains for ZDBF2 Gene

Gene Families for ZDBF2 Gene

HGNC:
  • ZDBF :Zinc fingers, DBF-type

Protein Domains for ZDBF2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZDBF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HCK1

UniProtKB/Swiss-Prot:

ZDBF2_HUMAN :
  • Q9HCK1
Similarity:
  • Contains 1 DBF4-type zinc finger.
genes like me logo Genes that share domains with ZDBF2: view

Function for ZDBF2 Gene

Gene Ontology (GO) - Molecular Function for ZDBF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ZDBF2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZDBF2 Gene

Localization for ZDBF2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZDBF2 Gene COMPARTMENTS Subcellular localization image for ZDBF2 gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZDBF2 Gene

Pathways for ZDBF2 Gene

SuperPathways for ZDBF2 Gene

No Data Available

Interacting Proteins for ZDBF2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000363545%0d%0a9606.ENSP00000323588%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000363545 Q9HCK1-ZDBF2_HUMAN for ZDBF2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for ZDBF2 Gene

None

No data available for Pathways by source for ZDBF2 Gene

Transcripts for ZDBF2 Gene

mRNA/cDNA for ZDBF2 Gene

(17) Selected AceView cDNA sequences:
(12) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZDBF2 Gene

Zinc finger, DBF-type containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZDBF2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZDBF2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDBF2 Gene

No ASD Table

Relevant External Links for ZDBF2 Gene

GeneLoc Exon Structure for
ZDBF2
ECgene alternative splicing isoforms for
ZDBF2

Expression for ZDBF2 Gene

mRNA expression in normal human tissues for ZDBF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZDBF2 Gene

SOURCE GeneReport for Unigene cluster for ZDBF2 Gene Hs.110489

genes like me logo Genes that share expressions with ZDBF2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZDBF2 Gene

Orthologs for ZDBF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZDBF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZDBF2 35
  • 99.41 (n)
  • 98.85 (a)
ZDBF2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZDBF2 35
  • 76.75 (n)
  • 57.62 (a)
ZDBF2 36
  • 55 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZDBF2 35
  • 76.75 (n)
  • 60.92 (a)
ZDBF2 36
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zdbf2 35
  • 70.16 (n)
  • 50.58 (a)
Zdbf2 16
Zdbf2 36
  • 41 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZDBF2 36
  • 19 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZDBF2 36
  • 24 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zdbf2 35
  • 69.38 (n)
  • 49.78 (a)
chicken
(Gallus gallus)
Aves ZDBF2 36
  • 28 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 14 (a)
OneToMany
-- 36
  • 31 (a)
OneToMany
Species with no ortholog for ZDBF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZDBF2 Gene

ENSEMBL:
Gene Tree for ZDBF2 (if available)
TreeFam:
Gene Tree for ZDBF2 (if available)

Paralogs for ZDBF2 Gene

No data available for Paralogs for ZDBF2 Gene

Variants for ZDBF2 Gene

Sequence variations from dbSNP and Humsavar for ZDBF2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs723606 -- 206,303,439(-) AAAGT(C/T)GGGCA intron-variant
rs895871 -- 206,278,506(-) AGACC(C/G)TATCT intron-variant
rs895872 -- 206,277,709(-) AGTTT(C/T)GAGAC intron-variant
rs1063875 -- 206,275,446(-) GTTTT(A/C)AAATA intron-variant
rs1080587 -- 206,287,533(+) ATAAT(G/T)TGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZDBF2 Gene

Variant ID Type Subtype PubMed ID
nsv875738 CNV Gain 21882294
nsv834516 CNV Gain 17160897

Relevant External Links for ZDBF2 Gene

HapMap Linkage Disequilibrium report
ZDBF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDBF2 Gene

Disorders for ZDBF2 Gene

No disorders were found for ZDBF2 Gene.

No data available for UniProtKB/Swiss-Prot for ZDBF2 Gene

Publications for ZDBF2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Identification of the mouse paternally expressed imprinted gene Zdbf2 on chromosome 1 and its imprinted human homolog ZDBF2 on chromosome 2. (PMID: 19200453) Kobayashi H. … Kono T. (Genomics 2009) 3
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  5. Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder. (PMID: 22688191) Bergen S.E. … Sullivan P.F. (Mol. Psychiatry 2012) 3

Products for ZDBF2 Gene

Sources for ZDBF2 Gene

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