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Aliases for ZDBF2 Gene

Aliases for ZDBF2 Gene

  • Zinc Finger DBF-Type Containing 2 2 3 5
  • KIAA1571 4

External Ids for ZDBF2 Gene

Previous GeneCards Identifiers for ZDBF2 Gene

  • GC02P206848
  • GC02P207139
  • GC02P198990

Summaries for ZDBF2 Gene

Entrez Gene Summary for ZDBF2 Gene

  • This gene encodes a protein containing DBF4-type zinc finger domains. This gene is imprinted and paternally expressed in lymphocytes but is more stochastically expressed in the placenta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

GeneCards Summary for ZDBF2 Gene

ZDBF2 (Zinc Finger DBF-Type Containing 2) is a Protein Coding gene. Diseases associated with ZDBF2 include Mental Retardation-Hypotonic Facies Syndrome, X-Linked. GO annotations related to this gene include nucleic acid binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDBF2 Gene

Genomics for ZDBF2 Gene

Regulatory Elements for ZDBF2 Gene

Enhancers for ZDBF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F205495 0.4 ENCODE 12.5 -778.0 -777960 2.4 MTA2 ZFP64 ZBTB11 JUNB ZNF140 REST ZNF623 TBX21 ZNF518A ZNF781 ZDBF2 LOC105373849 GC02P205442 PIR50611
GH02F206250 0.5 Ensembl ENCODE 12.4 -24.1 -24141 1.0 CTCF RNF2 POLR2A CBX2 RAD21 EZH2 GPR1 ZDBF2 RN7SKP200 SNORA41 EEF1B2 SNORD51 NDUFS1 HMGN1P6 LOC100132849
GH02F206245 0.8 Ensembl 11.6 -28.9 -28941 0.2 RAD51 RN7SKP200 GPR1 ZDBF2 SNORA41 EEF1B2 ADAM23 MDH1B LOC100132849 HMGN1P6
GH02F206246 0.2 Ensembl 11.6 -28.4 -28441 0.4 MTA2 NBN TBX21 SPI1 GPR1 RN7SKP200 ZDBF2 SNORA41 EEF1B2 ADAM23 LOC100132849 HMGN1P6
GH02F206247 0.5 Ensembl 11.6 -29.3 -29341 0.2 ZNF664 RAD51 MTA2 TBX21 RN7SKP200 GPR1 ZDBF2 SNORA41 EEF1B2 ADAM23 LOC100132849 HMGN1P6
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZDBF2 on UCSC Golden Path with GeneCards custom track

Promoters for ZDBF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000125108 860 2999 TBP ZNF76 FEZF1 ZBTB40 EGR1 ZNF366 SCRT2 CREM SMARCC1 ZNF362

Genomic Location for ZDBF2 Gene

206,274,641 bp from pter
206,314,438 bp from pter
39,798 bases
Plus strand

Genomic View for ZDBF2 Gene

Genes around ZDBF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDBF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDBF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDBF2 Gene

Proteins for ZDBF2 Gene

  • Protein details for ZDBF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DBF4-type zinc finger-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • Q6ZNP7
    • Q6ZSN8

    Protein attributes for ZDBF2 Gene

    2354 amino acids
    Molecular mass:
    265618 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC85454.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZDBF2 Gene

Post-translational modifications for ZDBF2 Gene

  • Ubiquitination at Lys 2133
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZDBF2 Gene

Domains & Families for ZDBF2 Gene

Gene Families for ZDBF2 Gene

Protein Domains for ZDBF2 Gene


Suggested Antigen Peptide Sequences for ZDBF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DBF4-type zinc finger.
  • Contains 1 DBF4-type zinc finger.
genes like me logo Genes that share domains with ZDBF2: view

Function for ZDBF2 Gene

Gene Ontology (GO) - Molecular Function for ZDBF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZDBF2: view

Phenotypes for ZDBF2 Gene

genes like me logo Genes that share phenotypes with ZDBF2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDBF2 Gene

Localization for ZDBF2 Gene

Subcellular locations from

Jensen Localization Image for ZDBF2 Gene COMPARTMENTS Subcellular localization image for ZDBF2 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZDBF2 Gene

Pathways & Interactions for ZDBF2 Gene

SuperPathways for ZDBF2 Gene

No Data Available

Interacting Proteins for ZDBF2 Gene

Gene Ontology (GO) - Biological Process for ZDBF2 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZDBF2 Gene

Transcripts for ZDBF2 Gene

mRNA/cDNA for ZDBF2 Gene

(14) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZDBF2 Gene

Zinc finger, DBF-type containing 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDBF2 Gene

No ASD Table

Relevant External Links for ZDBF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZDBF2 Gene

mRNA expression in normal human tissues for ZDBF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZDBF2 Gene

This gene is overexpressed in Fetal testis (25.2), Oral epithelium (13.0), Heart (10.1), and Fetal heart (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZDBF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZDBF2 Gene:


SOURCE GeneReport for Unigene cluster for ZDBF2 Gene:

genes like me logo Genes that share expression patterns with ZDBF2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZDBF2 Gene

Orthologs for ZDBF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZDBF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZDBF2 34 35
  • 99.41 (n)
(Bos Taurus)
Mammalia ZDBF2 34 35
  • 76.75 (n)
(Canis familiaris)
Mammalia ZDBF2 34 35
  • 76.75 (n)
(Mus musculus)
Mammalia Zdbf2 34 16 35
  • 70.16 (n)
(Rattus norvegicus)
Mammalia Zdbf2 34
  • 69.38 (n)
(Ornithorhynchus anatinus)
Mammalia ZDBF2 35
  • 24 (a)
(Monodelphis domestica)
Mammalia ZDBF2 35
  • 19 (a)
(Gallus gallus)
Aves ZDBF2 35
  • 28 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 31 (a)
-- 35
  • 14 (a)
Species where no ortholog for ZDBF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZDBF2 Gene

Gene Tree for ZDBF2 (if available)
Gene Tree for ZDBF2 (if available)

Paralogs for ZDBF2 Gene

No data available for Paralogs for ZDBF2 Gene

Variants for ZDBF2 Gene

Sequence variations from dbSNP and Humsavar for ZDBF2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs763186071 Uncertain significance 206,310,323(+) GGGGC(A/G)TGTGG reference, missense
rs879255650 Uncertain significance 206,310,777(+) ATTTT(-/TT)AATAG intron-variant, reference, frameshift-variant
rs10165697 -- 206,297,413(+) GTTAT(A/G)TGTTA intron-variant
rs10196686 -- 206,314,922(+) tttct(C/T)gaggc downstream-variant-500B
rs10206923 -- 206,290,105(+) gttga(A/G)gacta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZDBF2 Gene

Variant ID Type Subtype PubMed ID
esv3451203 CNV insertion 20981092
nsv834516 CNV gain 17160897

Variation tolerance for ZDBF2 Gene

Residual Variation Intolerance Score: 92.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.67; 65.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZDBF2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDBF2 Gene

Disorders for ZDBF2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZDBF2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
mental retardation-hypotonic facies syndrome, x-linked
  • mental retardation-hypotonic facies syndrome, x-linked, 1
- elite association - COSMIC cancer census association via MalaCards
Search ZDBF2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZDBF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZDBF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZDBF2 Gene

Publications for ZDBF2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64
  5. Protein phosphatase 1I^ isoforms linked interactions in the brain. (PMID: 23080069) Esteves S.L. … da Cruz e Silva E.F. (J. Mol. Neurosci. 2013) 3 64

Products for ZDBF2 Gene

Sources for ZDBF2 Gene

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