Aliases for ZDBF2 Gene
Aliases for ZDBF2 Gene
External Ids for ZDBF2 Gene
- HGNC: 29313
- Entrez Gene: 57683
- Ensembl: ENSG00000204186
- UniProtKB: Q9HCK1
Previous GeneCards Identifiers for ZDBF2 Gene
- GC02P206848
- GC02P207139
- GC02P198990
Summaries for ZDBF2 Gene
-
This gene encodes a protein containing DBF4-type zinc finger domains. This gene is imprinted and paternally expressed in lymphocytes but is more stochastically expressed in the placenta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
GeneCards Summary for ZDBF2 Gene
ZDBF2 (Zinc Finger DBF-Type Containing 2) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding.
No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDBF2 Gene
Genomics for ZDBF2 Gene
Regulatory Elements for ZDBF2 Gene
Enhancers for ZDBF2 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around ZDBF2 on UCSC Golden Path with GeneCards custom track
Promoters for ZDBF2 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around ZDBF2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ZDBF2 gene promoter:
Regulatory Element Products
Genomic Location for ZDBF2 Gene
- Chromosome:
- 2
- Start:
- 206,274,641 bp from pter
- End:
- 206,314,438 bp from pter
- Size:
- 39,798 bases
- Orientation:
- Plus strand
Genomic View for ZDBF2 Gene
Genes around ZDBF2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q33.3 by Ensembl
- 2q33.3 by Entrez Gene
- 2q33.3 by HGNC
ZDBF2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZDBF2 Gene
Proteins for ZDBF2 Gene
-
Protein details for ZDBF2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9HCK1-ZDBF2_HUMAN
- Recommended name:
- DBF4-type zinc finger-containing protein 2
- Protein Accession:
- Q9HCK1
- Q6ZNP7
- Q6ZSN8
Protein attributes for ZDBF2 Gene
- Size:
- 2354 amino acids
- Molecular mass:
- 265618 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAC85454.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for ZDBF2 Gene
Post-translational modifications for ZDBF2 Gene
Other Protein References for ZDBF2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ZDBF2
- Search GeneTex for Antibodies for ZDBF2
-
Santa Cruz Biotechnology (SCBT) Antibodies for ZDBF2
Protein Products
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- Novus Biologicals proteins for ZDBF2
- Search GeneTex for Proteins for ZDBF2
Assay Products
No data available for DME Specific Peptides for ZDBF2 Gene
Domains & Families for ZDBF2 Gene
Gene Families for ZDBF2 Gene
Suggested Antigen Peptide Sequences for ZDBF2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9HCK1- Similarity:
-
- Contains 1 DBF4-type zinc finger.
Function for ZDBF2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
Phenotypes for ZDBF2 Gene
- GenomeRNAi human phenotypes for ZDBF2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for ZDBF2 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for ZDBF2
-
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miRNA for ZDBF2 Gene
- miRTarBase miRNAs that target ZDBF2
-
- hsa-mir-493-5p (MIRT439240)
- hsa-mir-7847-3p (MIRT681042)
- hsa-mir-6880-5p (MIRT681043)
- hsa-mir-4792 (MIRT681044)
- hsa-mir-6799-5p (MIRT681045)
- hsa-mir-6851-5p (MIRT681046)
- hsa-mir-3689d (MIRT681047)
- hsa-mir-4746-3p (MIRT681048)
- hsa-mir-6086 (MIRT681049)
- hsa-mir-377-5p (MIRT681050)
- hsa-mir-6134 (MIRT681051)
- hsa-mir-610 (MIRT681052)
- hsa-mir-1247-3p (MIRT681053)
- hsa-mir-148a-5p (MIRT681054)
miRNA Products
- Search ViGene Biosciences for ZDBF2
Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for ZDBF2 gene
Clone Products
- OriGene clones in human for ZDBF2
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Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for ZDBF2 gene
-
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-
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Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDBF2 Gene
Localization for ZDBF2 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytosol | 3 |
| plasma membrane | 2 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZDBF2 Gene
Pathways & Interactions for ZDBF2 Gene
More details on SuperPathways for ZDBF2
No Data Available
Interacting Proteins for ZDBF2 Gene
No data available for Pathways by source and SIGNOR curated interactions for ZDBF2 Gene
Transcripts for ZDBF2 Gene
mRNA/cDNA for ZDBF2 Gene
- (12) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (17) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ZDBF2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ZDBF2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZDBF2
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miRNA Products
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Inhibitory RNA Products
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-
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Clone Products
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Flow Cytometry Products
Expression for ZDBF2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Pancreas (Endocrine System)
- Endocrine Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
- Endocrine Progenitor Cells Ventral Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Ventral Pancreatic Bud
-
Epithelial Cells
- Endocrine Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
- Endocrine Progenitor Cells Ventral Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Ventral Pancreatic Bud
-
Heart (Cardiovascular System)
- Cardiac Fibroblasts Myocardium
-
Fibroblasts
- Cardiac Fibroblasts Myocardium
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
This gene is overexpressed in Fetal testis (25.2), Oral epithelium (13.0), Heart (10.1), and Fetal heart (8.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZDBF2 Gene
SOURCE GeneReport for Unigene cluster for ZDBF2 Gene Hs.110489
Primer Products
-
OriGene qPCR primer pairs for ZDBF2
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZDBF2 Gene
Orthologs for ZDBF2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | ZDBF2 35 |
|
||
| ZDBF2 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | ZDBF2 35 |
|
||
| ZDBF2 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Zdbf2 35 |
|
||
| Zdbf2 16 |
|
||||
| Zdbf2 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | ZDBF2 35 |
|
||
| ZDBF2 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Zdbf2 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ZDBF2 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ZDBF2 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ZDBF2 36 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 36 |
|
OneToMany | |
| -- 36 |
|
OneToMany |
- Species with no ortholog for ZDBF2:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for ZDBF2 Gene
No data available for Paralogs for ZDBF2 Gene
Variants for ZDBF2 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs10932150 | - | 206,305,007(+) | TGTGA(A/G)AAAAT | reference, missense | |
| rs723606 | -- | 206,303,439(-) | AAAGT(C/T)GGGCA | intron-variant | |
| rs895871 | -- | 206,278,506(-) | AGACC(C/G)TATCT | intron-variant | |
| rs895872 | -- | 206,277,709(-) | AGTTT(C/T)GAGAC | intron-variant | |
| rs1975597 | -- | 206,312,603(-) | CCCCC(A/G)ACTCT | utr-variant-3-prime |
Residual Variation Intolerance Score:
92.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.67;
65.92% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZDBF2 Gene
Disorders for ZDBF2 Gene
Relevant External Links for ZDBF2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- ZDBF2
No disorders were found for ZDBF2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDBF2 Gene
Publications for ZDBF2 Gene
- Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
- A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
- Protein phosphatase 1I^ isoforms linked interactions in the brain. (PMID: 23080069) Esteves S.L. … da Cruz e Silva E.F. (J. Mol. Neurosci. 2013) 3
- The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PMID: 23667531) Cox J.L. … Rizzino A. (PLoS ONE 2013) 3
Products for ZDBF2 Gene
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Sources for ZDBF2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
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- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
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- (136) Genetics Home Reference
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- (138) MedlinePlus
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- (141) NCBI Bookshelf
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- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon