Aliases for ZDBF2 Gene
External Ids for ZDBF2 Gene
- HGNC: 29313
- Entrez Gene: 57683
- Ensembl: ENSG00000204186
- OMIM: 617059
- UniProtKB: Q9HCK1
Previous GeneCards Identifiers for ZDBF2 Gene
- GC02P206848
- GC02P207139
- GC02P198990
Summaries for ZDBF2 Gene
-
This gene encodes a protein containing DBF4-type zinc finger domains. This gene is imprinted and paternally expressed in lymphocytes but is more stochastically expressed in the placenta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
GeneCards Summary for ZDBF2 Gene
ZDBF2 (Zinc Finger DBF-Type Containing 2) is a Protein Coding gene. Diseases associated with ZDBF2 include Mental Retardation-Hypotonic Facies Syndrome, X-Linked. GO annotations related to this gene include nucleic acid binding.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDBF2 Gene
Genomics for ZDBF2 Gene
Regulatory Elements for ZDBF2 Gene
Enhancers for ZDBF2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH02G206229 | 1 | ENCODE | 10.9 | -44.3 | -44311 | 1.2 | PKNOX1 ARNT FEZF1 ZNF2 ZNF121 GLIS2 ZNF263 REST TSHZ1 ZNF488 | ZDBF2 RN7SKP200 GC02M206237 |
| GH02G206250 | 0.8 | Ensembl ENCODE | 12.5 | -24.1 | -24143 | 0.6 | CTCF RNF2 SUZ12 POLR2A RAD21 EZH2 | ZDBF2 RN7SKP200 GPR1 SNORA41 EEF1B2 SNORD51 NDUFS1 HMGN1P6 LOC100132849 |
| GH02G205495 | 0.8 | ENCODE | 12.5 | -778.0 | -777960 | 2.4 | ZFP64 ZNF140 BACH1 ZNF101 ZNF697 ZNF664 ARID3A ZNF791 FOS RELB | ENSG00000227946 ZDBF2 GC02P205442 PIR50611 |
| GH02G206377 | 0.8 | Ensembl ENCODE | 10.1 | +104.9 | 104873 | 3.4 | FOXA2 RBBP5 REST ATF2 | ZDBF2 GPR1 GC02P206391 GC02P206342 |
| GH02G206246 | 0.6 | Ensembl | 11.6 | -28.3 | -28341 | 0.2 | MTA2 BHLHE40 NBN RELB DPF2 TBX21 | GPR1 RN7SKP200 ZDBF2 SNORA41 EEF1B2 ADAM23 LOC100132849 HMGN1P6 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ZDBF2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ZDBF2 gene promoter:
Regulatory Element Products
Genomic Location for ZDBF2 Gene
- Chromosome:
- 2
- Start:
- 206,274,641 bp from pter
- End:
- 206,314,438 bp from pter
- Size:
- 39,798 bases
- Orientation:
- Plus strand
Genomic View for ZDBF2 Gene
Genes around ZDBF2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q33.3 by Ensembl
- 2q33.3 by Entrez Gene
- 2q33.3 by HGNC
ZDBF2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZDBF2 Gene
Proteins for ZDBF2 Gene
-
Protein details for ZDBF2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9HCK1-ZDBF2_HUMAN
- Recommended name:
- DBF4-type zinc finger-containing protein 2
- Protein Accession:
- Q9HCK1
- Q6ZNP7
- Q6ZSN8
Protein attributes for ZDBF2 Gene
- Size:
- 2354 amino acids
- Molecular mass:
- 265618 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAC85454.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for ZDBF2 Gene
Post-translational modifications for ZDBF2 Gene
Other Protein References for ZDBF2 Gene
Antibody Products
- Novus Biologicals Antibodies for ZDBF2
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- Search GeneTex for Antibodies for ZDBF2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ZDBF2
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- Novus Biologicals proteins for ZDBF2
- Search GeneTex for Proteins for ZDBF2
No data available for DME Specific Peptides for ZDBF2 Gene
Domains & Families for ZDBF2 Gene
Gene Families for ZDBF2 Gene
Suggested Antigen Peptide Sequences for ZDBF2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ZDBF2 Gene
Function for ZDBF2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ZDBF2 Gene
- GenomeRNAi human phenotypes for ZDBF2:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for ZDBF2 gene
-
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- Search ViGene Biosciences for ZDBF2
CRISPR Products
-
OriGene CRISPR knockouts for ZDBF2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZDBF2
- GenScript: Design CRISPR guide RNA sequences for ZDBF2
miRNA for ZDBF2 Gene
- miRTarBase miRNAs that target ZDBF2
-
- hsa-mir-493-5p (MIRT439240)
- hsa-mir-7847-3p (MIRT681042)
- hsa-mir-6880-5p (MIRT681043)
- hsa-mir-4792 (MIRT681044)
- hsa-mir-6799-5p (MIRT681045)
- hsa-mir-6851-5p (MIRT681046)
- hsa-mir-3689d (MIRT681047)
- hsa-mir-4746-3p (MIRT681048)
- hsa-mir-6086 (MIRT681049)
- hsa-mir-377-5p (MIRT681050)
- hsa-mir-6134 (MIRT681051)
- hsa-mir-610 (MIRT681052)
- hsa-mir-1247-3p (MIRT681053)
- hsa-mir-148a-5p (MIRT681054)
miRNA Products
- Search ViGene Biosciences for ZDBF2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ZDBF2
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-
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ZDBF2
-
ViGene Biosciences adenoviral particle packaged cDNA for ZDBF2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ZDBF2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ZDBF2 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDBF2 Gene
Localization for ZDBF2 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytosol | 3 |
| plasma membrane | 2 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZDBF2 Gene
Pathways & Interactions for ZDBF2 Gene
No Data Available
No data available for Pathways by source and SIGNOR curated interactions for ZDBF2 Gene
Transcripts for ZDBF2 Gene
mRNA/cDNA for ZDBF2 Gene
- (14) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (17) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ZDBF2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ZDBF2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZDBF2
- GenScript: Design CRISPR guide RNA sequences for ZDBF2
miRNA Products
- Search ViGene Biosciences for ZDBF2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ZDBF2
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-
ViGene Biosciences ready-to-package AAV shRNAs for ZDBF2 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for ZDBF2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZDBF2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for ZDBF2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Pancreas (Endocrine System)
- Endocrine Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
- Endocrine Progenitor Cells Ventral Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Ventral Pancreatic Bud
-
Epithelial Cells
- Endocrine Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
- Endocrine Progenitor Cells Ventral Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Ventral Pancreatic Bud
-
Heart (Cardiovascular System)
- Cardiac Fibroblasts Myocardium
-
Fibroblasts
- Cardiac Fibroblasts Myocardium
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
This gene is overexpressed in Fetal testis (25.2), Oral epithelium (13.0), Heart (10.1), and Fetal heart (8.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZDBF2 Gene
NURSA nuclear receptor signaling pathways regulating expression of ZDBF2 Gene:
ZDBF2SOURCE GeneReport for Unigene cluster for ZDBF2 Gene:
Hs.110489Evidence on tissue expression from TISSUES for ZDBF2 Gene
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for ZDBF2
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDBF2 Gene
Orthologs for ZDBF2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ZDBF2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ZDBF2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ZDBF2 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Zdbf2 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Zdbf2 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ZDBF2 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ZDBF2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ZDBF2 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany |
- Species where no ortholog for ZDBF2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for ZDBF2 Gene
No data available for Paralogs for ZDBF2 Gene
Variants for ZDBF2 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs763186071 | Uncertain significance | 206,310,323(+) | GGGGC(A/G)TGTGG | reference, missense | |
| rs879255650 | Uncertain significance | 206,310,777(+) | ATTTT(-/TT)AATAG | intron-variant, reference, frameshift-variant | |
| rs1000051241 | -- | 206,281,579(+) | ATATT(C/T)AGTCA | intron-variant | |
| rs1000226743 | -- | 206,287,251(+) | TTCTT(C/G)TGAGC | intron-variant | |
| rs1000237744 | -- | 206,280,943(+) | CAGCA(A/G)ATAAA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3451203 | CNV | insertion | 20981092 |
| nsv834516 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
92.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.67;
65.92% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ZDBF2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDBF2 Gene
Disorders for ZDBF2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| mental retardation-hypotonic facies syndrome, x-linked |
|
|
Search ZDBF2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for ZDBF2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- ZDBF2
No data available for UniProtKB/Swiss-Prot and Genatlas for ZDBF2 Gene
Publications for ZDBF2 Gene
- Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
- A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64
- Protein phosphatase 1I^ isoforms linked interactions in the brain. (PMID: 23080069) Esteves S.L. … da Cruz e Silva E.F. (J. Mol. Neurosci. 2013) 3 64
Products for ZDBF2 Gene
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- VectorBuilder custom plasmid, inducible vectors for ZDBF2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZDBF2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ZDBF2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
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- (90) Invitrogen
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- (92) Vector BioLabs
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- (100) COMPARTMENTS
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- (109) TreeFam
- (110) PathCards
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