ZCWPW2 Gene
protein-coding GIFtS: 39
GCID: GC03P028407
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zinc finger, CW type with PWWP domain 2
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Aliases
for ZCWPW2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger, CW Type With PWWP Domain 21 2 | | ZCW21 2 | | Zinc Finger CW-Type PWWP Domain Protein 22 |
Export aliases for ZCWPW2 gene to outside databasesPrevious GC identifer: GC00U920636 |
Summaries
for ZCWPW2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ZCWPW2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZCWPW2 gene promoter:
AML1a ATF-2 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 MEF-2A FOXJ2 (long isoform) aMEF-2 FOXJ2 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZCWPW2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZCWPW2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p24.1 Ensembl cytogenetic band: 3p24.1 HGNC cytogenetic band: 3p23ZCWPW2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P028407: view genomic region
(about GC identifiers)
Start:
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28,390,637 bp from pter |
End:
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28,579,613 bp from pter |
Size:
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188,977 bases |
Orientation:
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plus strand |
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Proteins
for ZCWPW2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZCPW2_HUMAN, Q504Y3 (See
protein sequence)Recommended Name: Zinc finger CW-type PWWP domain protein 2 Size: 356 amino acids; 41376 DaExplore the universe of human proteins at neXtProt for ZCWPW2: NX_Q504Y3
ZCWPW2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001035522.1
ENSEMBL proteins: ENSP00000395930 ENSP00000373278 ENSP00000393521 ENSP00000395687 ENSP00000395421 ENSP00000412386
Human Recombinant Protein Products:
ZCWPW2 Antibody Products:
Assay Products for ZCWPW2: |
Protein
Domains /
Families
for ZCWPW2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZCWPW2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q504Y3ProtoNet protein and cluster: Q504Y3 1 Blocks protein family: IPB000313 PWWP domain
UniProtKB/Swiss-Prot: ZCPW2_HUMAN, Q504Y3Similarity: Contains 1 CW-type zinc fingerSimilarity: Contains 1 PWWP domain |
Function
for ZCWPW2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZCWPW2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZCWPW2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZCWPW2 (NM_001040432) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZCWPW2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZCWPW2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCWPW2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0008270 | zinc ion binding |
IEA | -- |
ZCWPW2 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ZCWPW2:
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Pathways & Interactions
for ZCWPW2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZCWPW2
|
Drugs & Compounds
for ZCWPW2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZCWPW2
Search CenterWatch for drugs/clinical trials and news about ZCWPW2 / ZCPW2
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Transcripts
for ZCWPW2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZCWPW2 gene: NM_001040432.1 Unigene Clusters for ZCWPW2: Zinc finger, CW type with PWWP domain 2 Hs.539824 [show with all ESTs], Hs.659030 [show with all ESTs]Unigene Representative Sequences: BQ711957, BC0946966 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000420223 ENST00000383768(uc003ceh.3 uc003cei.3 uc010hfo.3)
ENST00000428875 ENST00000419130 ENST00000457897 ENST00000421010
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZCWPW2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZCWPW2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZCWPW2 (NM_001040432) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZCWPW2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZCWPW2 |
Additional cDNA sequence: BC065764.1 BC094696.1 16 DOTS entries: DT.86843919 DT.97797064 DT.121506044 DT.121507413 DT.121507799 DT.121508391 DT.121509673 DT.121650112 DT.40213413 DT.95248569 DT.99933203 DT.100714981 DT.75184548 DT.100046822 DT.121507065 DT.121508201 22 AceView cDNA sequences: AI678197 AI553945 BU508346 AW593058 CK822990 BC065764 BI520920 AI808897 BQ086331 CF552461 BQ102408 BX118914 BG496727 BM908208 CK822989 AW027938 AI677721 BG197719 BG199790 BI037904 BF575233 BG183206
GeneLoc Exon Structure
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Expression
for ZCWPW2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZCWPW2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGAGGAAAT
About this image
See ZCWPW2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZCWPW2
SOURCE GeneReport for Unigene clusters: Hs.539824 Hs.659030
SABiosciences Custom PCR Arrays for ZCWPW2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZCWPW2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZCWPW2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZCWPW2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZCWPW2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCWPW2 |
Orthologs
for ZCWPW2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZCWPW2 gene from 2/8 species (see all 8) About this table
ENSEMBL Gene Tree for ZCWPW2 (if available)
TreeFam Gene Tree for ZCWPW2 (if available) |
Paralogs
for ZCWPW2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZCWPW2 gene
- ZCWPW12
11 SIMAP similar genes for ZCWPW2 using alignment to 5 protein entries: ZCPW2_HUMAN (see all proteins):NF2 UTY CNOT2 FANCA GNPTAB FAM175A
FAM3A BUB1B AURA2 SUN3 ZNF564
ZCWPW2 for paralogs About GeneDecksing
|
Genomic Variants
for ZCWPW2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZCWPW2 (28390637 - 28579613 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZCWPW2
1 CNV: 98272 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZCWPW2 |
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Disorders
/ Diseases
for ZCWPW2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZCWPW2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZCWPW2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZCWPW2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants. (PubMed id 14607086)1, 3 Perry J. and Zhao Y. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Molecular characterization of a human monoclonal antibody to B antigen in ABO blood type. (PubMed id 12600744)1 Kaneko M....Osawa M. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for ZCWPW2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing ZCWPW2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing ZCWPW2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZCWPW2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZCWPW2 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for ZCWPW2 gene:
Search GeneIP for patents involving ZCWPW2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZCWPW2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZCWPW2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZCWPW2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZCWPW2 | | | OriGene Protein Over-expression Lysate for ZCWPW2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZCWPW2 | | OriGene 3'-UTR Clone for ZCWPW2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZCWPW2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZCWPW2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 |  |  |  | |
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 | | | ZCWPW2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCWPW2 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZCWPW2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZCWPW2 |
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