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Aliases for ZCWPW2 Gene

Aliases for ZCWPW2 Gene

  • Zinc Finger, CW Type With PWWP Domain 2 2 3
  • Zinc Finger CW-Type PWWP Domain Protein 2 3
  • ZCW2 3

External Ids for ZCWPW2 Gene

Previous GeneCards Identifiers for ZCWPW2 Gene

  • GC00U920636

Summaries for ZCWPW2 Gene

GeneCards Summary for ZCWPW2 Gene

ZCWPW2 (Zinc Finger, CW Type With PWWP Domain 2) is a Protein Coding gene. An important paralog of this gene is ZCWPW1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCWPW2 Gene

Genomics for ZCWPW2 Gene

Genomic Location for ZCWPW2 Gene

Start:
28,348,948 bp from pter
End:
28,538,122 bp from pter
Size:
189,175 bases
Orientation:
Plus strand

Genomic View for ZCWPW2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZCWPW2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCWPW2 Gene

Proteins for ZCWPW2 Gene

  • Protein details for ZCWPW2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q504Y3-ZCPW2_HUMAN
    Recommended name:
    Zinc finger CW-type PWWP domain protein 2
    Protein Accession:
    Q504Y3
    Secondary Accessions:

    Protein attributes for ZCWPW2 Gene

    Size:
    356 amino acids
    Molecular mass:
    41376 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZCWPW2 Gene

neXtProt entry for ZCWPW2 Gene

Proteomics data for ZCWPW2 Gene at MOPED

Post-translational modifications for ZCWPW2 Gene

No Post-translational modifications

Other Protein References for ZCWPW2 Gene

No data available for DME Specific Peptides for ZCWPW2 Gene

Domains for ZCWPW2 Gene

Protein Domains for ZCWPW2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZCWPW2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q504Y3

UniProtKB/Swiss-Prot:

ZCPW2_HUMAN :
  • Q504Y3
Domain:
  • Contains 1 PWWP domain.
Similarity:
  • Contains 1 CW-type zinc finger.
genes like me logo Genes that share domains with ZCWPW2: view

No data available for Gene Families for ZCWPW2 Gene

Function for ZCWPW2 Gene

Gene Ontology (GO) - Molecular Function for ZCWPW2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ZCWPW2: view

Phenotypes for ZCWPW2 Gene

GenomeRNAi human phenotypes for ZCWPW2:
genes like me logo Genes that share phenotypes with ZCWPW2: view

miRNA for ZCWPW2 Gene

miRTarBase miRNAs that target ZCWPW2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZCWPW2 Gene

Localization for ZCWPW2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZCWPW2 Gene COMPARTMENTS Subcellular localization image for ZCWPW2 gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
extracellular 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZCWPW2 Gene

Pathways for ZCWPW2 Gene

SuperPathways for ZCWPW2 Gene

No Data Available

Interacting Proteins for ZCWPW2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000373278%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000373278 for ZCWPW2 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for ZCWPW2 Gene

None

No data available for Pathways by source for ZCWPW2 Gene

Transcripts for ZCWPW2 Gene

Unigene Clusters for ZCWPW2 Gene

Zinc finger, CW type with PWWP domain 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZCWPW2 Gene

No ASD Table

Relevant External Links for ZCWPW2 Gene

GeneLoc Exon Structure for
ZCWPW2
ECgene alternative splicing isoforms for
ZCWPW2

Expression for ZCWPW2 Gene

mRNA expression in normal human tissues for ZCWPW2 Gene

mRNA differential expression in normal tissues according to GTEx for ZCWPW2 Gene

This gene is overexpressed in Testis (6.0).

SOURCE GeneReport for Unigene cluster for ZCWPW2 Gene Hs.539824

genes like me logo Genes that share expressions with ZCWPW2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for ZCWPW2 Gene

Orthologs for ZCWPW2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZCWPW2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZCWPW2 35
  • 98.88 (n)
  • 97.47 (a)
ZCWPW2 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZCWPW2 35
  • 85.12 (n)
  • 78.81 (a)
ZCWPW2 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZCWPW2 35
  • 88.2 (n)
  • 82.44 (a)
ZCWPW2 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zcwpw2 35
  • 76.5 (n)
  • 66.77 (a)
Zcwpw2 16
Zcwpw2 36
  • 54 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZCWPW2 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 7 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zcwpw2 35
  • 74.75 (n)
  • 65.3 (a)
Species with no ortholog for ZCWPW2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZCWPW2 Gene

ENSEMBL:
Gene Tree for ZCWPW2 (if available)
TreeFam:
Gene Tree for ZCWPW2 (if available)

Paralogs for ZCWPW2 Gene

Paralogs for ZCWPW2 Gene

Selected SIMAP similar genes for ZCWPW2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZCWPW2: view

Variants for ZCWPW2 Gene

Sequence variations from dbSNP and Humsavar for ZCWPW2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs963362 -- 28,525,620(-) AGGCA(A/G)CTCAC downstream-variant-500B
rs969443 -- 28,495,734(-) GAGAT(A/C)CATAC intron-variant
rs974933 -- 28,521,555(-) TCTAC(C/T)TCCCG intron-variant
rs1037723 -- 28,478,188(+) GTATG(C/T)ATATG intron-variant
rs1075144 -- 28,468,088(+) atttc(A/G)aattc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZCWPW2 Gene

Variant ID Type Subtype PubMed ID
nsv876649 CNV Gain 21882294
esv996568 OTHER Inversion 20482838
nsv876650 CNV Loss 21882294
esv2480638 CNV Deletion 19546169
nsv3746 CNV Insertion 18451855
esv2664973 CNV Deletion 23128226
esv2674700 CNV Deletion 23128226
esv2725072 CNV Deletion 23290073

Relevant External Links for ZCWPW2 Gene

HapMap Linkage Disequilibrium report
ZCWPW2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZCWPW2 Gene

Disorders for ZCWPW2 Gene

No disorders were found for ZCWPW2 Gene.

No data available for UniProtKB/Swiss-Prot for ZCWPW2 Gene

Publications for ZCWPW2 Gene

  1. The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants. (PMID: 14607086) Perry J. … Zhao Y. (Trends Biochem. Sci. 2003) 2 3
  2. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Molecular characterization of a human monoclonal antibody to B antigen in ABO blood type. (PMID: 12600744) Kaneko M. … Osawa M. (Immunol. Lett. 2003) 3

Products for ZCWPW2 Gene

Sources for ZCWPW2 Gene

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