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ZCWPW2 Gene

protein-coding   GIFtS: 40
GCID: GC03P028407

Zinc Finger, CW Type With PWWP Domain 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, CW Type With PWWP Domain 21 2
ZCW22
Zinc Finger CW-Type PWWP Domain Protein 22

External Ids:    HGNC: 235741   Entrez Gene: 1520982   Ensembl: ENSG000002065597   UniProtKB: Q504Y33   

Export aliases for ZCWPW2 gene to outside databases

Previous GC identifer: GC00U920636


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZCWPW2 Gene:
ZCWPW2 (zinc finger, CW type with PWWP domain 2) is a protein-coding gene. An important paralog of this gene is ZCWPW1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZCWPW2 gene promoter:
         AML1a   ATF-2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   MEF-2A   FOXJ2 (long isoform)   aMEF-2   FOXJ2   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZCWPW2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.1   Ensembl cytogenetic band:  3p24.1   HGNC cytogenetic band: 3p23

ZCWPW2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZCWPW2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P028407:  view genomic region     (about GC identifiers)

Start:
28,390,637 bp from pter      End:
28,579,613 bp from pter
Size:
188,977 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZCPW2_HUMAN, Q504Y3 (See protein sequence)
Recommended Name: Zinc finger CW-type PWWP domain protein 2  
Size: 356 amino acids; 41376 Da

Explore the universe of human proteins at neXtProt for ZCWPW2: NX_Q504Y3

Explore proteomics data for ZCWPW2 at MOPED


See ZCWPW2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001035522.1  
ENSEMBL proteins: 
 ENSP00000395930   ENSP00000373278   ENSP00000393521   ENSP00000395687   ENSP00000395421  
 ENSP00000412386  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR000313 PWWP_dom
 IPR011124 Znf_CW

Graphical View of Domain Structure for InterPro Entry Q504Y3

ProtoNet protein and cluster: Q504Y3

1 Blocks protein domain: IPB000313 PWWP domain

UniProtKB/Swiss-Prot: ZCPW2_HUMAN, Q504Y3
Similarity: Contains 1 CW-type zinc finger
Similarity: Contains 1 PWWP domain


Find genes that share domains with ZCWPW2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008270zinc ion binding IEA--
     
Find genes that share ontologies with ZCWPW2           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for ZCWPW2:
 Increased HPV18 LCR reporter a  Low eccentricity cells 

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for ZCWPW2

miRNA
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miRTarBase miRNAs that target ZCWPW2:
hsa-mir-335-5p (MIRT018374)

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
nucleus2
cytoskeleton1
extracellular1
plasma membrane1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZCWPW2
Interactions:

    Search GeneGlobe Interaction Network for ZCWPW2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ZCWPW2 (ZCPW2)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ZCWPW2 gene: 
NM_001040432.1  

Unigene Clusters for ZCWPW2:

Zinc finger, CW type with PWWP domain 2
Hs.539824  [show with all ESTs], Hs.659030  [show with all ESTs]
Unigene Representative Sequences: BQ711957, BC094696
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000420223 ENST00000383768(uc003ceh.3 uc003cei.3 uc010hfo.3)
ENST00000428875 ENST00000419130 ENST00000457897 ENST00000421010
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hsa-miR-616* hsa-miR-373*
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Additional mRNA sequence: 

BC065764.1 BC094696.1 

16 DOTS entries:

DT.86843919  DT.97797064  DT.121506044  DT.121507413  DT.121507799  DT.121508391  DT.121509673  DT.121650112 
DT.40213413  DT.95248569  DT.99933203  DT.100714981  DT.75184548  DT.100046822  DT.121507065  DT.121508201 

22 AceView cDNA sequences:

AI678197 BU508346 AI553945 AW593058 BG496727 BI520920 BC065764 CF552461 
AI808897 BQ086331 BM908208 BQ102408 BX118914 CK822989 CK822990 AI677721 
BG197719 AW027938 BG199790 BI037904 BF575233 BG183206 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZCWPW2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAGAGGAAAT
ZCWPW2 Expression
About this image

ZCWPW2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ZCWPW2 Protein Expression

SOURCE GeneReport for Unigene clusters: Hs.539824 Hs.659030
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for ZCWPW2 gene from Selected species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Zcwpw21 , 5 zinc finger, CW type with PWWP domain 21, 5 76.5(n)1
66.77(a)1
  9 (69.83 cM)5
1000396811  XM_006512413.11  XP_006512476.11 
 1179644885 


ENSEMBL Gene Tree for ZCWPW2 (if available)
TreeFam Gene Tree for ZCWPW2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ZCWPW2 gene
ZCWPW12  
12 SIMAP similar genes for ZCWPW2 using alignment to 5 protein entries:     ZCPW2_HUMAN (see all proteins):
NF2    UTY    CNOT2    FANCA    GNPTAB    ECD
FAM175A    FAM3A    BUB1B    AURA2    SUN3    ZNF564

Find genes that share paralogs with ZCWPW2           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZCWPW2 (see all 2435)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs130904391,2
C,F,A,H--28429991(+) tgtttT/Gccctt 1 -- int1 trp314Minor allele frequency- G:0.25NS EA NA WA CSA 792
rs1505153271,2
--28430017(+) TAACAC/TAAATA 1 -- int10--------
rs1178253201,2
F--28430060(+) ATGACA/GTAAAG 1 -- int11Minor allele frequency- G:0.01EA 120
rs1394380361,2
--28430069(+) AGTCAA/GTATAT 1 -- int10--------
rs1493261741,2
--28430116(+) AACAAA/GGATAT 1 -- int10--------
rs1423315751,2
C--28430147(+) TTCAT-/AATAA 
        
AATAA
1 -- int10--------
rs1445981281,2
C--28430206(+) GTCATA/GTAGTC 1 -- int10--------
rs1397098221,2
--28430245(+) TTTGTA/GTTTTC 1 -- int10--------
rs1452099401,2
C--28430312(+) GTGGGA/CCATTA 1 -- int10--------
rs1859010651,2
--28430411(+) CTTGTA/GTTGCA 1 -- int10--------

HapMap Linkage Disequilibrium report for ZCWPW2 (28390637 - 28579613 bp)

Structural Variations
     Database of Genomic Variants (DGV) 8 variations for ZCWPW2:    About this table    
Variant IDTypeSubtypePubMed ID
esv2674700CNV Deletion23128226
esv2664973CNV Deletion23128226
esv2725072CNV Deletion23290073
esv2480638CNV Deletion19546169
nsv3746CNV Insertion18451855
nsv876650CNV Loss21882294
nsv876649CNV Gain21882294
esv996568OTHER Inversion20482838

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ZCWPW2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ZCWPW2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants. (PubMed id 14607086)1, 3 Perry J. and Zhao Y. (Trends Biochem. Sci. 2003)
  2. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (EMBO J. 2013)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Molecular characterization of a human monoclonal antibody to B antigen in ABO blood type. (PubMed id 12600744)1 Kaneko M....Osawa M. (Immunol. Lett. 2003)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 152098 HGNC: 23574 AceView: LOC152098 Ensembl:ENSG00000206559 euGenes: HUgn152098
ECgene: ZCWPW2 H-InvDB: ZCWPW2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ZCWPW2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ZCWPW2 gene:
Search GeneIP for patents involving ZCWPW2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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