ZCWPW1 Gene
protein-coding GIFtS: 41
GCID: GC07M099998
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|
zinc finger, CW type with PWWP domain 1(Previous names: zinc finger, CW-type with PWWP domain 1 )
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Aliases
for ZCWPW1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger, CW Type With PWWP Domain 11 2 | | ZCW11 2 | | Zinc Finger, CW-Type With PWWP Domain 11 2 | | DKFZp434N05101 | | FLJ100571 | | Zinc Finger CW-Type PWWP Domain Protein 12 |
Export aliases for ZCWPW1 gene to outside databasesPrevious GC identifers: GC07M099609 GC07M099643 GC07M099836 GC07M094634 |
Summaries
for ZCWPW1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ZCWPW1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZCWPW1 gene promoter:
Nkx2-5 Roaz C/EBPalpha Egr-2 CREB HOXA5 deltaCREB FOXO1a Zic3 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZCWPW1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZCWPW1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q22.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q22.1ZCWPW1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M099998: view genomic region
(about GC identifiers)
Start:
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99,998,449 bp from pter |
End:
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100,026,615 bp from pter |
Size:
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28,167 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 99,358,580-99,386,387 |
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Proteins
for ZCWPW1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZCPW1_HUMAN, Q9H0M4 (See
protein sequence)Recommended Name: Zinc finger CW-type PWWP domain protein 1 Size: 648 amino acids; 72007 Da
Sequence caution: Sequence=CAB66669.1; Type=Frameshift; Positions=487;
2 PDB 3D structures from  and Proteopedia  for ZCWPW1:2E61 (3D)
2RR4 (3D)
Secondary accessions: A8MVF5 B4DUQ2 Q8NA98 Q9BUD0 Q9NWF7Alternative splicing: 5 isoforms: Q9H0M4-1 Q9H0M4-2 Q9H0M4-3 Q9H0M4-4 Q9H0M4-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZCWPW1: NX_Q9H0M4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H0M4
ZCWPW1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001244937.1 NP_060454.3
ENSEMBL proteins: ENSP00000381109 ENSP00000419187 ENSP00000354210 ENSP00000418351 ENSP00000419447 ENSP00000314880
Human Recombinant Protein Products for ZCWPW1:
ZCWPW1 Antibody Products:
Assay Products for ZCWPW1: |
Protein
Domains /
Families
for ZCWPW1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZCWPW1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H0M4ProtoNet protein and cluster: Q9H0M4 2 Blocks protein families: IPB000313 PWWP domain IPB011124 CW-type Zn-finger
UniProtKB/Swiss-Prot: ZCPW1_HUMAN, Q9H0M4Similarity: Contains 1 CW-type zinc fingerSimilarity: Contains 1 PWWP domain |
Function
for ZCWPW1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
ZCWPW1 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for ZCWPW1:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZCWPW1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZCWPW1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZCWPW1 (NM_017984) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZCWPW1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZCWPW1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCWPW1 |
|
Pathways & Interactions
for ZCWPW1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZCWPW1
|
Drugs & Compounds
for ZCWPW1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZCWPW1
Search CenterWatch for drugs/clinical trials and news about ZCWPW1 / ZCPW1
|
Transcripts
for ZCWPW1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZCWPW1 gene (2 alternative transcripts): NM_001258008.1 NM_017984.4 Unigene Cluster for ZCWPW1: Zinc finger, CW type with PWWP domain 1 Hs.105191 [show with all ESTs]Unigene Representative Sequence: NM_0179849 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000479315 ENST00000398027(uc011kjp.2 uc011kjq.2 uc003uut.3)
ENST00000490721(uc003uus.3) ENST00000490089(uc003uur.3) ENST00000360951(uc003uuu.1)
ENST00000471336 ENST00000464510(uc011kjt.1 uc011kju.1) ENST00000472716
ENST00000324725(uc011kjr.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZCWPW1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZCWPW1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZCWPW1 (NM_017984) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZCWPW1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZCWPW1 |
Additional cDNA sequence: AK000919.1 AK093038.1 AK299989.1 AK300745.1 AK302108.1 AK316553.1 AL136735.1 BC002725.1 8 DOTS entries: DT.95366710 DT.100754442 DT.100018530 DT.100000784 DT.101955656 DT.303055 DT.92423945 DT.95153282 24/44 AceView cDNA sequences (see all 44): NM_017984 BP360311 AI969074 AK000919 BF222828 CD243484 AI650718 AL136735 BI256491 BM976699 BF195822 AL048981 AX747875 AK093038 BE395614 BG391077 BC002725 AU117432 CA313330 BU682053 CF142457 BP346419 CA406045 BQ060983
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ZCWPW1 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZCWPW1
|
Expression
for ZCWPW1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZCWPW1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAGATGTTG
About this image
See ZCWPW1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZCWPW1
SOURCE GeneReport for Unigene cluster: Hs.105191
SABiosciences Custom PCR Arrays for ZCWPW1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZCWPW1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZCWPW1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZCWPW1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZCWPW1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCWPW1 |
Orthologs
for ZCWPW1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZCWPW1 gene from 2/9 species (see all 9) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
ZCWPW16 |
-- |
60(a) |
1 ↔ 1 |
GL343895.1(37774-45807) |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
23(a) |
1 → many |
Group11.9(75071-134432) |
ENSEMBL Gene Tree for ZCWPW1 (if available)
TreeFam Gene Tree for ZCWPW1 (if available) |
Paralogs
for ZCWPW1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZCWPW1 gene
- ZCWPW22
ZCWPW1 for paralogs About GeneDecksing
|
Genomic Variants
for ZCWPW1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZCWPW1 (99998449 - 100026615 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ZCWPW1
1 CNV: 4549
1 Indel: 59437 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZCWPW1 |
|
Disorders
/ Diseases
for ZCWPW1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZCWPW1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZCWPW1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZCWPW1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
- Structural insight into the zinc finger CW domain as a histone modification reader. (PubMed id 20826339)1, 3 He F.... Muto Y. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants. (PubMed id 14607086)1, 3 Perry J. and Zhao Y. (2003)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZCWPW1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZCWPW1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZCWPW1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZCWPW1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZCWPW1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZCWPW1 gene:
Search GeneIP for patents involving ZCWPW1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZCWPW1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZCWPW1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZCWPW1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZCWPW1 | | | OriGene Protein Over-expression Lysate for ZCWPW1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZCWPW1 | | OriGene 3'-UTR Clone for ZCWPW1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZCWPW1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZCWPW1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| |  |  |  |  | | | | |
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 | | | ZCWPW1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCWPW1 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for ZCWPW1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZCWPW1 |
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