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Aliases for ZCWPW1 Gene

Aliases for ZCWPW1 Gene

  • Zinc Finger CW-Type And PWWP Domain Containing 1 2 3 5
  • Zinc Finger, CW-Type With PWWP Domain 1 2 3
  • Zinc Finger CW-Type PWWP Domain Protein 1 3
  • Zinc Finger CW-Type And PWWP Domain 1 3
  • ZCW1 3

External Ids for ZCWPW1 Gene

Previous GeneCards Identifiers for ZCWPW1 Gene

  • GC07M099609
  • GC07M099643
  • GC07M099836
  • GC07M099998
  • GC07M094634

Summaries for ZCWPW1 Gene

GeneCards Summary for ZCWPW1 Gene

ZCWPW1 (Zinc Finger CW-Type And PWWP Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is ZCWPW2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCWPW1 Gene

Genomics for ZCWPW1 Gene

Regulatory Elements for ZCWPW1 Gene

Enhancers for ZCWPW1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ZCWPW1 on UCSC Golden Path with GeneCards custom track

Promoters for ZCWPW1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ZCWPW1 Gene

100,400,826 bp from pter
100,429,414 bp from pter
28,589 bases
Minus strand

Genomic View for ZCWPW1 Gene

Genes around ZCWPW1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZCWPW1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZCWPW1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCWPW1 Gene

Proteins for ZCWPW1 Gene

  • Protein details for ZCWPW1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger CW-type PWWP domain protein 1
    Protein Accession:
    Secondary Accessions:
    • A8MVF5
    • B4DUQ2
    • Q8NA98
    • Q9BUD0
    • Q9NWF7

    Protein attributes for ZCWPW1 Gene

    648 amino acids
    Molecular mass:
    72007 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAB66669.1; Type=Frameshift; Positions=487; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZCWPW1 Gene

    Alternative splice isoforms for ZCWPW1 Gene


neXtProt entry for ZCWPW1 Gene

Post-translational modifications for ZCWPW1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZCWPW1 Gene

No data available for DME Specific Peptides for ZCWPW1 Gene

Domains & Families for ZCWPW1 Gene

Gene Families for ZCWPW1 Gene

Protein Domains for ZCWPW1 Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PWWP domain.
  • Contains 1 CW-type zinc finger.
  • Contains 1 PWWP domain.
  • Contains 1 CW-type zinc finger.
genes like me logo Genes that share domains with ZCWPW1: view

Function for ZCWPW1 Gene

Gene Ontology (GO) - Molecular Function for ZCWPW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ZCWPW1: view
genes like me logo Genes that share phenotypes with ZCWPW1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZCWPW1 Gene

Localization for ZCWPW1 Gene

Subcellular locations from

Jensen Localization Image for ZCWPW1 Gene COMPARTMENTS Subcellular localization image for ZCWPW1 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZCWPW1 Gene

Pathways & Interactions for ZCWPW1 Gene

SuperPathways for ZCWPW1 Gene

No Data Available

Interacting Proteins for ZCWPW1 Gene

Selected Interacting proteins: Q9H0M4-ZCPW1_HUMAN for ZCWPW1 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for ZCWPW1 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZCWPW1 Gene

Drugs & Compounds for ZCWPW1 Gene

No Compound Related Data Available

Transcripts for ZCWPW1 Gene

Unigene Clusters for ZCWPW1 Gene

Zinc finger, CW type with PWWP domain 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZCWPW1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP2: - -
SP3: - -
SP4: -
SP5: -

Relevant External Links for ZCWPW1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZCWPW1 Gene

mRNA expression in normal human tissues for ZCWPW1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZCWPW1 Gene

This gene is overexpressed in Testis (x11.5).

Protein differential expression in normal tissues from HIPED for ZCWPW1 Gene

This gene is overexpressed in Ovary (24.7), Testis (18.7), and Fetal ovary (17.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZCWPW1 Gene

Protein tissue co-expression partners for ZCWPW1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZCWPW1 Gene:


SOURCE GeneReport for Unigene cluster for ZCWPW1 Gene:

genes like me logo Genes that share expression patterns with ZCWPW1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ZCWPW1 Gene

Orthologs for ZCWPW1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZCWPW1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZCWPW1 34
  • 81.46 (n)
  • 70.19 (a)
  • 68 (a)
(Canis familiaris)
Mammalia ZCWPW1 34
  • 81.72 (n)
  • 71.22 (a)
  • 70 (a)
(Mus musculus)
Mammalia Zcwpw1 34
  • 74.57 (n)
  • 61.22 (a)
Zcwpw1 16
Zcwpw1 35
  • 61 (a)
(Pan troglodytes)
Mammalia ZCWPW1 34
  • 99.59 (n)
  • 99.23 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia LOC100910636 34
  • 74.24 (n)
  • 61.44 (a)
(Ornithorhynchus anatinus)
Mammalia ZCWPW1 35
  • 38 (a)
(Anolis carolinensis)
Reptilia ZCWPW1 35
  • 53 (a)
Species where no ortholog for ZCWPW1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZCWPW1 Gene

Gene Tree for ZCWPW1 (if available)
Gene Tree for ZCWPW1 (if available)

Paralogs for ZCWPW1 Gene

Paralogs for ZCWPW1 Gene

genes like me logo Genes that share paralogs with ZCWPW1: view

Variants for ZCWPW1 Gene

Sequence variations from dbSNP and Humsavar for ZCWPW1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs6465770 - 100,417,088(+) ATCAG(C/T)AGCAG reference, missense
rs6970350 - 100,406,771(+) TGTTT(C/T)TCCAA reference, missense, utr-variant-3-prime
rs2158862 -- 100,404,173(+) TTTAT(C/G/T)CTACC intron-variant
rs2286265 -- 100,409,342(-) ACTAC(A/G)TAAAT intron-variant
rs2286266 -- 100,406,989(-) TTTGG(A/C)TAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZCWPW1 Gene

Variant ID Type Subtype PubMed ID
dgv1226e199 CNV deletion 23128226
esv2734888 CNV deletion 23290073
nsv1144194 CNV deletion 24896259
nsv527107 CNV loss 19592680
nsv819923 CNV loss 19587683
nsv831071 CNV loss 17160897

Variation tolerance for ZCWPW1 Gene

Residual Variation Intolerance Score: 88.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.19; 61.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZCWPW1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZCWPW1 Gene

Disorders for ZCWPW1 Gene

Relevant External Links for ZCWPW1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZCWPW1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZCWPW1 Gene

Publications for ZCWPW1 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 65
  2. Structural insight into the zinc finger CW domain as a histone modification reader. (PMID: 20826339) He F. … Muto Y. (Structure 2010) 2 3 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants. (PMID: 14607086) Perry J. … Zhao Y. (Trends Biochem. Sci. 2003) 2 3 65

Products for ZCWPW1 Gene

Sources for ZCWPW1 Gene

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