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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZCWPW1 Gene

protein-coding   GIFtS: 43
GCID: GC07M099998

Zinc Finger, CW Type With PWWP Domain 1

(Previous names: zinc finger, CW-type with PWWP domain 1)
  Search for ZCWPW1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger, CW Type With PWWP Domain 11 2
Zinc Finger, CW-Type With PWWP Domain 11 2
ZCW12
Zinc Finger CW-Type PWWP Domain Protein 12

External Ids:    HGNC: 234861   Entrez Gene: 550632   Ensembl: ENSG000000784877   UniProtKB: Q9H0M43   

Export aliases for ZCWPW1 gene to outside databases

Previous GC identifers: GC07M099609 GC07M099643 GC07M099836 GC07M094634


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZCWPW1 Gene: 
ZCWPW1 (zinc finger, CW type with PWWP domain 1) is a protein-coding gene. GO annotations related to this gene include zinc ion binding. An important paralog of this gene is ZCWPW2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZCWPW1 gene promoter:
         Nkx2-5   Roaz   C/EBPalpha   Egr-2   CREB   HOXA5   deltaCREB   FOXO1a   Zic3   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZCWPW1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZCWPW1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZCWPW1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

ZCWPW1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZCWPW1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M099998:  view genomic region     (about GC identifiers)

Start:
99,998,449 bp from pter      End:
100,026,615 bp from pter
Size:
28,167 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 99,358,580-99,386,387     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZCPW1_HUMAN, Q9H0M4 (See protein sequence)
Recommended Name: Zinc finger CW-type PWWP domain protein 1  
Size: 648 amino acids; 72007 Da
Sequence caution: Sequence=CAB66669.1; Type=Frameshift; Positions=487;
2 PDB 3D structures from and Proteopedia for ZCWPW1:
2E61 (3D)        2RR4 (3D)    
Secondary accessions: A8MVF5 B4DUQ2 Q8NA98 Q9BUD0 Q9NWF7
Alternative splicing: 5 isoforms:  Q9H0M4-1   Q9H0M4-2   Q9H0M4-3   Q9H0M4-4   Q9H0M4-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZCWPW1: NX_Q9H0M4

Explore proteomics data for ZCWPW1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H0M4

  • ZCWPW1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZCWPW1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001244937.1  NP_060454.3  

    ENSEMBL proteins: 
     ENSP00000381109   ENSP00000419187   ENSP00000354210   ENSP00000418351   ENSP00000419447  
     ENSP00000314880  

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    Cloud-Clone Corp. CLIAs for ZCWPW1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR000313 PWWP
     IPR011124 Znf_CW

    Graphical View of Domain Structure for InterPro Entry Q9H0M4

    ProtoNet protein and cluster: Q9H0M4

    2 Blocks protein domains:
    IPB000313 PWWP domain
    IPB011124 CW-type Zn-finger


    UniProtKB/Swiss-Prot: ZCPW1_HUMAN, Q9H0M4
    Similarity: Contains 1 CW-type zinc finger
    Similarity: Contains 1 PWWP domain


    ZCWPW1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
         
    ZCWPW1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZCWPW1:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZCWPW1 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZCWPW1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZCWPW1 (ZCPW1)

    Search CenterWatch for drugs/clinical trials and news about ZCWPW1 / ZCPW1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZCWPW1 gene (2 alternative transcripts): 
    NM_001258008.1  NM_017984.4  

    Unigene Cluster for ZCWPW1:

    Zinc finger, CW type with PWWP domain 1
    Hs.105191  [show with all ESTs]
    Unigene Representative Sequence: NM_017984
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000479315 ENST00000398027(uc011kjp.2 uc011kjq.2 uc003uut.3)
    ENST00000490721(uc003uus.3) ENST00000490089(uc003uur.3) ENST00000360951(uc003uuu.1)
    ENST00000471336 ENST00000464510(uc011kjt.1 uc011kju.1) ENST00000472716
    ENST00000324725(uc011kjr.2)
    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZCWPW1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZCWPW1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZCWPW1
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                         Customized lentivirus expression plasmids for stable overexpression of ZCWPW1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ZCWPW1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZCWPW1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZCWPW1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZCWPW1

    Additional mRNA sequence: 

    AK000919.1 AK093038.1 AK299989.1 AK300745.1 AK302108.1 AK316553.1 AL136735.1 BC002725.1 

    8 DOTS entries:

    DT.95366710  DT.100754442  DT.100018530  DT.100000784  DT.101955656  DT.303055  DT.92423945  DT.95153282 

    24/44 AceView cDNA sequences (see all 44):

    AK000919 AL136735 AI969074 NM_017984 CD243484 BI256491 BP360311 AI650718 
    BF222828 AK093038 BU682053 BI668728 BQ060983 BE395614 BF195822 CF142457 
    BC002725 AL048981 BP346419 CA406045 BG391077 AA133439 AU117432 CA313330 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZCWPW1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                                                                                                                          
    SP2:                                                        -     -                                                                           
    SP3:                                                        -     -                                                                           
    SP4:        -                                                                                                                                 
    SP5:                                                              -                                                                           


    ECgene alternative splicing isoforms for ZCWPW1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZCWPW1 expression in normal human tissues (normalized intensities)      ZCWPW1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGATGTTG
    ZCWPW1 Expression
    About this image


    ZCWPW1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)
             XX Germ Cells Ovigerous Cord
     
     Gonad
             XX Germ Cells Ovigerous Cord
     
     Testis (Reproductive System)

    See ZCWPW1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZCWPW1

    SOURCE GeneReport for Unigene cluster: Hs.105191
        SABiosciences Custom PCR Arrays for ZCWPW1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCWPW1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZCWPW1 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zcwpw11 , 5 zinc finger, CW type with PWWP domain 11, 5 74.79(n)1
    62.18(a)1
      5 (76.71 cM)5
    3816781  NM_001005426.21  NP_001005426.21 
     1377877985 
    lizard
    (Anolis carolinensis)
    Reptilia ZCWPW16
    zinc finger, CW type with PWWP domain 1
    54(a)
    1 ↔ 1
    GL343895.1(16538-51358)


    ENSEMBL Gene Tree for ZCWPW1 (if available)
    TreeFam Gene Tree for ZCWPW1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZCWPW1 gene
    ZCWPW22  

    ZCWPW1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/467 SNPs in ZCWPW1 are shown (see all 467)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1112687251,2
    C,F--99998414(+) GCTCCC/TGCTAG 2 -- int11Minor allele frequency- T:0.50WA 2
    rs1455605491,2
    C--99998431(+) TGACGC/TGCCAC 2 -- int10--------
    rs734014661,2
    C,F--99998432(+) GACGCG/ACCACA 2 -- int13Minor allele frequency- A:0.24WA CSA 122
    rs3743160951,2
    C--99998595(+) CCTGCA/GCCCCA 2 -- ut310--------
    rs117698861,2
    C,F,H--99998607(+) AGAAGG/AGAGAA 2 -- ut31 ese3 trp314Minor allele frequency- A:0.08NS EA NA 2024
    rs1996228311,2
    --99998669(+) GTCCTC/TGCCAT 3 K E mis1 ut310--------
    rs2020518141,2
    C--99998720(+) TCTCCC/TAACAT 3 R G mis1 ut311Minor allele frequency- T:0.00EU 1321
    rs1453083671,2
    C,F--99998750(+) GTCCAG/AGTCAC 3 /L syn1 ut311Minor allele frequency- A:0.01EU 1323
    rs1831117311,2
    --99998766(+) GCTTCA/GTCCTC 3 D syn1 ut310--------
    rs1880453241,2
    C--99998864(+) TGATAA/GGCCCA 4 L A syn10--------

    HapMap Linkage Disequilibrium report for ZCWPW1 (99998449 - 100026615 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ZCWPW1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2734888CNV Deletion23290073
    dgv1226e199CNV Deletion23128226
    dgv7398n71CNV Loss21882294
    nsv527107CNV Loss19592680
    nsv831071CNV Loss17160897
    nsv819923CNV Loss19587683
    nsv888779CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZCWPW1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZCWPW1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    2. Structural insight into the zinc finger CW domain as a histone modification reader. (PubMed id 20826339)1, 3 He F.... Muto Y. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants. (PubMed id 14607086)1, 3 Perry J. and Zhao Y. (2003)
    6. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55063 HGNC: 23486 AceView: ZCWPW1 Ensembl:ENSG00000078487 euGenes: HUgn55063
    ECgene: ZCWPW1 H-InvDB: ZCWPW1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZCWPW1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZCWPW1 gene:
    Search GeneIP for patents involving ZCWPW1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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