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Aliases for ZCRB1 Gene

Aliases for ZCRB1 Gene

  • Zinc Finger CCHC-Type And RNA Binding Motif Containing 1 2 3
  • U11/U12 Small Nuclear Ribonucleoprotein 31 KDa Protein 3 4
  • Zinc Finger CCHC-Type And RNA Binding Motif 1 3 5
  • U11/U12 SnRNP 31 KDa Protein 3 4
  • U11/U12 SnRNP 31K 2 3
  • U11/U12-31K 3 4
  • SNRNP31 3
  • ZCCHC19 3
  • MADP-1 3
  • MADP1 3
  • RBM36 3

External Ids for ZCRB1 Gene

Previous GeneCards Identifiers for ZCRB1 Gene

  • GC12M040993
  • GC12M042705
  • GC12M039732

Summaries for ZCRB1 Gene

Entrez Gene Summary for ZCRB1 Gene

  • Pre-mRNA splicing is catalyzed by the spliceosome. U12-type spliceosome binds U12-type pre-mRNAs and recognizes the 5' splice site and branch-point sequence. U11 and U12 snRNPs are components of U12-type spliceosome and function as a molecular bridge connecting both ends of the intron. The protein encoded by this gene contains a RNA recognition motif. It was identified as one of the protein components of U11/U12 snRNPs. This protein and many other U11/U12 snRNP proteins are highly conserved in organisms known to contain U12-type introns. These proteins have been shown to be essential for cell viability, suggesting the key roles in U12-type splicing. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZCRB1 Gene

ZCRB1 (Zinc Finger CCHC-Type And RNA Binding Motif Containing 1) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and nucleotide binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCRB1 Gene

Genomics for ZCRB1 Gene

Regulatory Elements for ZCRB1 Gene

Enhancers for ZCRB1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZCRB1 on UCSC Golden Path with GeneCards custom track

Promoters for ZCRB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZCRB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZCRB1 Gene

42,312,078 bp from pter
42,326,130 bp from pter
14,053 bases
Minus strand

Genomic View for ZCRB1 Gene

Genes around ZCRB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZCRB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZCRB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCRB1 Gene

Proteins for ZCRB1 Gene

  • Protein details for ZCRB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger CCHC-type and RNA-binding motif-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q6PJX0
    • Q96TA6

    Protein attributes for ZCRB1 Gene

    217 amino acids
    Molecular mass:
    24592 Da
    Quaternary structure:
    • Component of the U11/U12 snRNPs that are part of the U12-type spliceosome.

    Three dimensional structures from OCA and Proteopedia for ZCRB1 Gene

neXtProt entry for ZCRB1 Gene

Proteomics data for ZCRB1 Gene at MOPED

Post-translational modifications for ZCRB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZCRB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZCRB1 Gene

Domains & Families for ZCRB1 Gene

Suggested Antigen Peptide Sequences for ZCRB1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RRM (RNA recognition motif) domain.
  • Contains 1 CCHC-type zinc finger.
  • Contains 1 RRM (RNA recognition motif) domain.
  • Contains 1 CCHC-type zinc finger.
genes like me logo Genes that share domains with ZCRB1: view

Function for ZCRB1 Gene

Molecular function for ZCRB1 Gene

UniProtKB/Swiss-Prot Induction:
Up-regulated by morphine. Down-regulated at 30-36 degrees Celsius while it is up-regulated at 39 degrees Celsius.

Gene Ontology (GO) - Molecular Function for ZCRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003723 RNA binding IBA --
genes like me logo Genes that share ontologies with ZCRB1: view

Phenotypes for ZCRB1 Gene

GenomeRNAi human phenotypes for ZCRB1:
genes like me logo Genes that share phenotypes with ZCRB1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZCRB1 Gene

Localization for ZCRB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZCRB1 Gene

Nucleus, nucleoplasm.

Subcellular locations from

Jensen Localization Image for ZCRB1 Gene COMPARTMENTS Subcellular localization image for ZCRB1 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZCRB1 Gene

Pathways & Interactions for ZCRB1 Gene

genes like me logo Genes that share pathways with ZCRB1: view

Pathways by source for ZCRB1 Gene

Interacting Proteins for ZCRB1 Gene

Gene Ontology (GO) - Biological Process for ZCRB1 Gene


No data available for SIGNOR curated interactions for ZCRB1 Gene

Drugs & Compounds for ZCRB1 Gene

No Compound Related Data Available

Transcripts for ZCRB1 Gene

Unigene Clusters for ZCRB1 Gene

Zinc finger CCHC-type and RNA binding motif 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZCRB1 Gene

No ASD Table

Relevant External Links for ZCRB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZCRB1 Gene

mRNA expression in normal human tissues for ZCRB1 Gene

Protein differential expression in normal tissues from HIPED for ZCRB1 Gene

This gene is overexpressed in Testis (32.6), CD8 Tcells (18.0), Rectum (7.5), and Blymphocyte (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZCRB1 Gene

SOURCE GeneReport for Unigene cluster for ZCRB1 Gene Hs.496279

genes like me logo Genes that share expression patterns with ZCRB1: view

Protein tissue co-expression partners for ZCRB1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZCRB1 Gene

Orthologs for ZCRB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZCRB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZCRB1 35
  • 95.39 (n)
  • 98.62 (a)
ZCRB1 36
  • 99 (a)
(Canis familiaris)
Mammalia ZCRB1 35
  • 95.08 (n)
  • 98.62 (a)
ZCRB1 36
  • 99 (a)
(Mus musculus)
Mammalia Zcrb1 35
  • 89.25 (n)
  • 94.93 (a)
Zcrb1 16
Zcrb1 36
  • 95 (a)
(Pan troglodytes)
Mammalia ZCRB1 35
  • 99.69 (n)
  • 100 (a)
ZCRB1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Zcrb1 35
  • 90.02 (n)
  • 95.85 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 89 (a)
-- 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia ZCRB1 36
  • 93 (a)
(Gallus gallus)
Aves ZCRB1 35
  • 81.79 (n)
  • 86.57 (a)
ZCRB1 36
  • 89 (a)
(Anolis carolinensis)
Reptilia ZCRB1 36
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zcrb1 35
  • 76.28 (n)
  • 79.53 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23452 35
(Danio rerio)
Actinopterygii zcrb1 35
  • 73.96 (n)
  • 82.03 (a)
zcrb1 36
  • 78 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.615 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013420 35
  • 54.4 (n)
  • 50 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
Species with no ortholog for ZCRB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZCRB1 Gene

Gene Tree for ZCRB1 (if available)
Gene Tree for ZCRB1 (if available)

Paralogs for ZCRB1 Gene

(4) SIMAP similar genes for ZCRB1 Gene using alignment to 4 proteins: Pseudogenes for ZCRB1 Gene

genes like me logo Genes that share paralogs with ZCRB1: view

No data available for Paralogs for ZCRB1 Gene

Variants for ZCRB1 Gene

Sequence variations from dbSNP and Humsavar for ZCRB1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs17852093 - 42,313,928(+) TCTTT(G/T)GAGGC reference, missense
rs14821 -- 42,312,946(+) TTTTT(C/T)TTGGG utr-variant-3-prime
rs10880283 -- 42,314,539(+) ATCAT(G/T)CCGTT intron-variant
rs10880284 -- 42,316,622(+) AGGAA(A/T)AAATA intron-variant
rs10880285 -- 42,318,748(+) AGTGC(A/G)TGAGC intron-variant

Variation tolerance for ZCRB1 Gene

Residual Variation Intolerance Score: 45.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.48% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ZCRB1 Gene

Disorders for ZCRB1 Gene

Relevant External Links for ZCRB1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZCRB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZCRB1 Gene

Publications for ZCRB1 Gene

  1. Isolation, expression, and characterization of the human ZCRB1 gene mapped to 12q12. (PMID: 16959469) Wang H. … Sato K. (Genomics 2007) 2 3 4 23 67
  2. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PMID: 15146077) Will C.L. … Luehrmann R. (RNA 2004) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Binding of the 5'-untranslated region of coronavirus RNA to zinc finger CCHC-type and RNA-binding motif 1 enhances viral replication and transcription. (PMID: 22362731) Tan Y.W. … Liu D.X. (Nucleic Acids Res. 2012) 3

Products for ZCRB1 Gene

Sources for ZCRB1 Gene