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Aliases for ZCRB1 Gene

Aliases for ZCRB1 Gene

  • Zinc Finger CCHC-Type And RNA Binding Motif 1 2 3
  • U11/U12 Small Nuclear Ribonucleoprotein 31 KDa Protein 3 4
  • U11/U12 SnRNP 31 KDa Protein 3 4
  • U11/U12 SnRNP 31K 2 3
  • U11/U12-31K 3 4
  • MADP1 3 6
  • Zinc Finger CCHC-Type And RNA-Binding Motif-Containing Protein 1 3
  • SNRNP31 3
  • ZCCHC19 3
  • MADP-1 3
  • RBM36 3

External Ids for ZCRB1 Gene

Previous GeneCards Identifiers for ZCRB1 Gene

  • GC12M040993
  • GC12M042705
  • GC12M039732

Summaries for ZCRB1 Gene

Entrez Gene Summary for ZCRB1 Gene

  • Pre-mRNA splicing is catalyzed by the spliceosome. U12-type spliceosome binds U12-type pre-mRNAs and recognizes the 5' splice site and branch-point sequence. U11 and U12 snRNPs are components of U12-type spliceosome and function as a molecular bridge connecting both ends of the intron. The protein encoded by this gene contains a RNA recognition motif. It was identified as one of the protein components of U11/U12 snRNPs. This protein and many other U11/U12 snRNP proteins are highly conserved in organisms known to contain U12-type introns. These proteins have been shown to be essential for cell viability, suggesting the key roles in U12-type splicing. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZCRB1 Gene

ZCRB1 (Zinc Finger CCHC-Type And RNA Binding Motif 1) is a Protein Coding gene. Diseases associated with ZCRB1 include morphine dependence. GO annotations related to this gene include RNA binding and nucleotide binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCRB1 Gene

Genomics for ZCRB1 Gene

Regulatory Elements for ZCRB1 Gene

Genomic Location for ZCRB1 Gene

Start:
42,312,078 bp from pter
End:
42,326,130 bp from pter
Size:
14,053 bases
Orientation:
Minus strand

Genomic View for ZCRB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZCRB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCRB1 Gene

Proteins for ZCRB1 Gene

  • Protein details for ZCRB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBF4-ZCRB1_HUMAN
    Recommended name:
    Zinc finger CCHC-type and RNA-binding motif-containing protein 1
    Protein Accession:
    Q8TBF4
    Secondary Accessions:
    • Q6PJX0
    • Q96TA6

    Protein attributes for ZCRB1 Gene

    Size:
    217 amino acids
    Molecular mass:
    24592 Da
    Quaternary structure:
    • Component of the U11/U12 snRNPs that are part of the U12-type spliceosome.

    Three dimensional structures from OCA and Proteopedia for ZCRB1 Gene

neXtProt entry for ZCRB1 Gene

Proteomics data for ZCRB1 Gene at MOPED

Post-translational modifications for ZCRB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZCRB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZCRB1 Gene

Domains for ZCRB1 Gene

Gene Families for ZCRB1 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing
  • ZCCHC :Zinc fingers, CCHC domain containing

Suggested Antigen Peptide Sequences for ZCRB1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TBF4

UniProtKB/Swiss-Prot:

ZCRB1_HUMAN :
  • Q8TBF4
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
Similarity:
  • Contains 1 CCHC-type zinc finger.
genes like me logo Genes that share domains with ZCRB1: view

Function for ZCRB1 Gene

Molecular function for ZCRB1 Gene

UniProtKB/Swiss-Prot Induction: Up-regulated by morphine. Down-regulated at 30-36 degrees Celsius while it is up-regulated at 39 degrees Celsius.

Gene Ontology (GO) - Molecular Function for ZCRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ZCRB1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZCRB1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZCRB1 Gene

Localization for ZCRB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZCRB1 Gene

Nucleus, nucleoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZCRB1 Gene COMPARTMENTS Subcellular localization image for ZCRB1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZCRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IEA --
GO:0005689 U12-type spliceosomal complex IDA 15146077
genes like me logo Genes that share ontologies with ZCRB1: view

Pathways for ZCRB1 Gene

SuperPathways for ZCRB1 Gene

No Data Available

Interacting Proteins for ZCRB1 Gene

Gene Ontology (GO) - Biological Process for ZCRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IC 15146077
genes like me logo Genes that share ontologies with ZCRB1: view

No data available for Pathways by source for ZCRB1 Gene

Transcripts for ZCRB1 Gene

Unigene Clusters for ZCRB1 Gene

Zinc finger CCHC-type and RNA binding motif 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZCRB1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZCRB1 Gene

No ASD Table

Relevant External Links for ZCRB1 Gene

GeneLoc Exon Structure for
ZCRB1
ECgene alternative splicing isoforms for
ZCRB1

Expression for ZCRB1 Gene

mRNA expression in normal human tissues for ZCRB1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ZCRB1 Gene

SOURCE GeneReport for Unigene cluster for ZCRB1 Gene Hs.496279

genes like me logo Genes that share expressions with ZCRB1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZCRB1 Gene

Orthologs for ZCRB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZCRB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZCRB1 35
  • 99.69 (n)
  • 100 (a)
ZCRB1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZCRB1 35
  • 95.39 (n)
  • 98.62 (a)
ZCRB1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZCRB1 35
  • 95.08 (n)
  • 98.62 (a)
ZCRB1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zcrb1 35
  • 89.25 (n)
  • 94.93 (a)
Zcrb1 16
Zcrb1 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 89 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ZCRB1 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zcrb1 35
  • 90.02 (n)
  • 95.85 (a)
chicken
(Gallus gallus)
Aves ZCRB1 35
  • 81.79 (n)
  • 86.57 (a)
ZCRB1 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZCRB1 36
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23452 35
tropical clawed frog
(Silurana tropicalis)
Amphibia zcrb1 35
  • 76.28 (n)
  • 79.53 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.615 35
zebrafish
(Danio rerio)
Actinopterygii zcrb1 35
  • 73.96 (n)
  • 82.03 (a)
zcrb1 36
  • 78 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013420 35
  • 54.4 (n)
  • 50 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToOne
Species with no ortholog for ZCRB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZCRB1 Gene

ENSEMBL:
Gene Tree for ZCRB1 (if available)
TreeFam:
Gene Tree for ZCRB1 (if available)

Paralogs for ZCRB1 Gene

Selected SIMAP similar genes for ZCRB1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ZCRB1 Gene

genes like me logo Genes that share paralogs with ZCRB1: view

No data available for Paralogs for ZCRB1 Gene

Variants for ZCRB1 Gene

Sequence variations from dbSNP and Humsavar for ZCRB1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs14821 -- 42,312,946(+) TTTTT(C/T)TTGGG utr-variant-3-prime
rs3761677 -- 42,313,635(+) GCAAG(C/G)ACTAT intron-variant
rs3834716 -- 42,322,227(+) TGTAA(-/T)AGTCT intron-variant
rs4435065 -- 42,318,702(+) AAGAG(A/G)AGCTT intron-variant
rs4768397 -- 42,318,254(+) GTAAA(A/G)TGATT intron-variant

Relevant External Links for ZCRB1 Gene

HapMap Linkage Disequilibrium report
ZCRB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZCRB1 Gene

Disorders for ZCRB1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ZCRB1 Gene including...

Search for ZCRB1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ZCRB1 Gene

genes like me logo Genes that share disorders with ZCRB1: view

No data available for UniProtKB/Swiss-Prot for ZCRB1 Gene

Publications for ZCRB1 Gene

  1. Isolation, expression, and characterization of the human ZCRB1 gene mapped to 12q12. (PMID: 16959469) Wang H. … Sato K. (Genomics 2007) 2 3 4 23
  2. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PMID: 15146077) Will C.L. … Luehrmann R. (RNA 2004) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for ZCRB1 Gene

Sources for ZCRB1 Gene

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