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ZCRB1 Gene

protein-coding   GIFtS: 48
GCID: GC12M042705

Zinc Finger CCHC-Type And RNA Binding Motif 1

  See ZCRB1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger CCHC-Type And RNA Binding Motif 11 2     MADP-12
U11/U12 SnRNP 31K1 2     RBM362
U11/U12-31K2 3     SNRNP312
U11/U12 Small Nuclear Ribonucleoprotein 31 KDa Protein2 3     ZCCHC192
U11/U12 SnRNP 31 KDa Protein2 3     Zinc Finger CCHC-Type And RNA-Binding Motif-Containing Protein 12
MADP12 5     

External Ids:    HGNC: 296201   Entrez Gene: 854372   Ensembl: ENSG000001391687   OMIM: 6107505   UniProtKB: Q8TBF43   

Export aliases for ZCRB1 gene to outside databases

Previous GC identifers: GC12M040993 GC12M039732


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZCRB1 Gene:
Pre-mRNA splicing is catalyzed by the spliceosome. U12-type spliceosome binds U12-type pre-mRNAs and recognizes
the 5' splice site and branch-point sequence. U11 and U12 snRNPs are components of U12-type spliceosome and
function as a molecular bridge connecting both ends of the intron. The protein encoded by this gene contains a
RNA recognition motif. It was identified as one of the protein components of U11/U12 snRNPs. This protein and
many other U11/U12 snRNP proteins are highly conserved in organisms known to contain U12-type introns. These
proteins have been shown to be essential for cell viability, suggesting the key roles in U12-type splicing.
(provided by RefSeq, Jul 2008)

GeneCards Summary for ZCRB1 Gene:
ZCRB1 (zinc finger CCHC-type and RNA binding motif 1) is a protein-coding gene. Diseases associated with ZCRB1 include morphine dependence. GO annotations related to this gene include RNA binding and nucleotide binding.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZCRB1 gene promoter:
         HFH-3   AML1a   Pbx1a   FOXD3   Cdc5   HEN1   FOXI1   PPAR-gamma1   Ik-2   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZCRB1 promoter sequence
   Search Chromatin IP Primers for ZCRB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZCRB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q12   Ensembl cytogenetic band:  12q12   HGNC cytogenetic band: 12q12

ZCRB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZCRB1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M042705:  view genomic region     (about GC identifiers)

Start:
42,705,880 bp from pter      End:
42,719,932 bp from pter
Size:
14,053 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZCRB1_HUMAN, Q8TBF4 (See protein sequence)
Recommended Name: Zinc finger CCHC-type and RNA-binding motif-containing protein 1  
Size: 217 amino acids; 24592 Da
Subunit: Component of the U11/U12 snRNPs that are part of the U12-type spliceosome
1 PDB 3D structure from and Proteopedia for ZCRB1:
2E5H (3D)    
Secondary accessions: Q6PJX0 Q96TA6

Explore the universe of human proteins at neXtProt for ZCRB1: NX_Q8TBF4

Explore proteomics data for ZCRB1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZCRB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_149105.3  
    ENSEMBL proteins: 
     ENSP00000266529   ENSP00000446732   ENSP00000448780  

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    Cloud-Clone Corp. Proteins for ZCRB1

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZCCHC: Zinc fingers, CCHC domain containing
    RBM: RNA binding motif (RRM) containing

    3 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom
     IPR001878 Znf_CCHC

    Graphical View of Domain Structure for InterPro Entry Q8TBF4

    ProtoNet protein and cluster: Q8TBF4

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB001878 C2HC-type zinc-finger signature


    UniProtKB/Swiss-Prot: ZCRB1_HUMAN, Q8TBF4
    Similarity: Contains 1 CCHC-type zinc finger
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Find genes that share domains with ZCRB1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZCRB1_HUMAN, Q8TBF4
    Induction: Up-regulated by morphine. Down-regulated at 30-36 degrees Celsius while it is up-regulated at 39
    degrees Celsius

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0008270zinc ion binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with ZCRB1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZCRB1
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    1 qRT-PCR Assays for microRNA that regulate ZCRB1:
    hsa-miR-9*
    SwitchGear 3'UTR luciferase reporter plasmidZCRB1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZCRB1_HUMAN, Q8TBF4: Nucleus, nucleoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm IEA--
    GO:0005689U12-type spliceosomal complex IDA15146077

    Find genes that share ontologies with ZCRB1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZCRB1
    Interactions:

        Search GeneGlobe Interaction Network for ZCRB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for ZCRB1 (ENSP000002665294) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    BUD13ENSP000002602104STRING: ENSP00000260210
    CRNKL1ENSP000003665574STRING: ENSP00000366557
    ISY1ENSP000003769734STRING: ENSP00000376973
    PLRG1ENSP000003031914STRING: ENSP00000303191
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    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IC15146077

    Find genes that share ontologies with ZCRB1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZCRB1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZCRB1 gene: 
    NM_033114.3  

    Unigene Cluster for ZCRB1:

    Zinc finger CCHC-type and RNA binding motif 1
    Hs.496279  [show with all ESTs]
    Unigene Representative Sequence: NM_033114
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000266529(uc001rmz.3) ENST00000552673 ENST00000552235 ENST00000548022
    ENST00000551102
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate ZCRB1:
    hsa-miR-9*
    SwitchGear 3'UTR luciferase reporter plasmidZCRB1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZCRB1
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ZCRB1
      QuantiFast Probe-based Assays in human, mouse, rat ZCRB1

    Additional mRNA sequence: 

    AB062361.1 AK308244.1 BC005099.1 BC010177.2 BC022543.1 

    11 DOTS entries:

    DT.116810  DT.100668548  DT.100752017  DT.102835879  DT.95361981  DT.121307710  DT.75103947  DT.99932087 
    DT.102835878  DT.121192387  DT.100844153 

    Selected AceView cDNA sequences (see all 169):

    NM_033114 AW572084 AI972713 BE263543 CK902423 CB158981 AI493902 AW337514 
    AI270376 BU680559 AI014789 BE855883 CA423047 AA603381 BE048205 BE550392 
    AI199265 BM842826 AA425036 AA298232 AL598360 AI480348 BQ003638 AA736513 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZCRB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGACTTCTG
    ZCRB1 Expression
    About this image

    ZCRB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZCRB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.496279
        Custom PCR Arrays for ZCRB1
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZCRB1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zcrb11 , 5 zinc finger CCHC-type and RNA binding motif 11, 5 89.25(n)1
    94.93(a)1
      15 (47.53 cM)5
    671971  NM_026025.21  NP_080301.11 
     933860975 
    chicken
    (Gallus gallus)
    Aves ZCRB11 zinc finger CCHC-type and RNA binding motif 1 81.79(n)
    86.57(a)
      417791  NM_001277358.1  NP_001264287.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZCRB16
    zinc finger CCHC-type and RNA binding motif 1
    92(a)
    1 ↔ 1
    5(55278327-55285534)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.234522 Xenopus laevis transcribed sequence with moderate similarity more 77.98(n)    CF520994.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zcrb11 zinc finger CCHC-type and RNA binding motif 1 73.96(n)
    82.03(a)
      550251  NM_001017589.1  NP_001017589.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0134201 AgaP_AGAP013420 54.4(n)
    50(a)
      11175609  XM_003436654.1  XP_003436702.1 


    ENSEMBL Gene Tree for ZCRB1 (if available)
    TreeFam Gene Tree for ZCRB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZCRB1 gene
    4 SIMAP similar genes for ZCRB1 using alignment to 4 protein entries:     ZCRB1_HUMAN (see all proteins):
    CIRBP    RBMX2    FUSIP1    SRSF7

    Find genes that share paralogs with ZCRB1           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for ZCRB1
    PGOHUM00000261177 PGOHUM00000249163 PGOHUM00000261803


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZCRB1 (see all 267)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1384006791,2
    C--42705469(+) CCGAGA/GCGGGT 1 -- ds50010--------
    rs111814151,2
    C,F,A,H--42705526(+) AACCCC/TCAACT 1 -- ds50019Minor allele frequency- T:0.18NA WA CSA EA 256
    rs748147321,2
    C--42705695(+) GACTTC/TGTTTC 1 -- ds50015Minor allele frequency- T:0.10WA CSA NA EA 361
    rs1439509591,2
    C--42705696(+) ACTTCA/GTTTCA 1 -- ds50010--------
    rs355928161,2
    C--42705738(+) AAAAAC/-AAACC 1 -- ds50011Minor allele frequency- -:0.00NA 2
    rs2018826521,2
    C--42705772(+) ATGGC-/CAAA  
            
    CAGAT
    1 -- ds50010--------
    rs732856101,2
    C,F--42705780(+) ACAGAT/CGGTTG 1 -- ds50012Minor allele frequency- C:0.05WA 120
    rs1426220691,2
    C--42705872(+) TGGAA-/ACACAAG 1 -- ds50010--------
    rs1467995821,2
    C--42705985(+) TAGTTA/GAAAAA 1 -- ut310--------
    rs1826364501,2
    --42706020(+) AACAAC/TATAGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZCRB1 (42705880 - 42719932 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ZCRB1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZCRB1
    DNA2.0 Custom Variant and Variant Library Synthesis for ZCRB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610750    OMIM disorders: --

    1 disease for ZCRB1:    
    About MalaCards
    morphine dependence

    1 disease from the University of Copenhagen DISEASES database for ZCRB1:
    Morphine dependence

    Find genes that share disorders with ZCRB1           About GenesLikeMe


    Export disorders for ZCRB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZCRB1 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with ZCRB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation, expression, and characterization of the human ZCRB1 gene mapped to 12q12. (PubMed id 16959469)1, 2, 3, 9 Wang H.... Sato K. (Genomics 2007)
    2. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PubMed id 15146077)1, 2, 3 Will C.L.... Luehrmann R. (RNA 2004)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. Binding of the 5'-untranslated region of coronavirus RNA to zinc finger CCHC-type and RNA-binding motif 1 enhances viral replication and transcription. (PubMed id 22362731)1 Tan Y.W....Liu D.X. (Nucleic Acids Res. 2012)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    10. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 85437 HGNC: 29620 AceView: MADP-1 Ensembl:ENSG00000139168 euGenes: HUgn85437
    ECgene: ZCRB1 H-InvDB: ZCRB1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZCRB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZCRB1 gene:
    Search GeneIP for patents involving ZCRB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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