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Aliases for ZCCHC9 Gene

Aliases for ZCCHC9 Gene

  • Zinc Finger CCHC-Type Containing 9 2 3
  • Zinc Finger, CCHC Domain Containing 9 3 5
  • Protein Phosphatase 1, Regulatory Subunit 41 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 41 2
  • PPP1R41 3

External Ids for ZCCHC9 Gene

Previous GeneCards Identifiers for ZCCHC9 Gene

  • GC05P080682
  • GC05P080633
  • GC05P075807
  • GC05P080597

Summaries for ZCCHC9 Gene

GeneCards Summary for ZCCHC9 Gene

ZCCHC9 (Zinc Finger CCHC-Type Containing 9) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and poly(A) RNA binding.

UniProtKB/Swiss-Prot for ZCCHC9 Gene

  • May down-regulate transcription mediated by NF-kappa-B and the serum response element.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCCHC9 Gene

Genomics for ZCCHC9 Gene

Regulatory Elements for ZCCHC9 Gene

Promoters for ZCCHC9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZCCHC9 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZCCHC9 Gene

Chromosome:
5
Start:
81,301,583 bp from pter
End:
81,313,344 bp from pter
Size:
11,762 bases
Orientation:
Plus strand

Genomic View for ZCCHC9 Gene

Genes around ZCCHC9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZCCHC9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZCCHC9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCCHC9 Gene

Proteins for ZCCHC9 Gene

  • Protein details for ZCCHC9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N567-ZCHC9_HUMAN
    Recommended name:
    Zinc finger CCHC domain-containing protein 9
    Protein Accession:
    Q8N567
    Secondary Accessions:
    • B2RAE7
    • Q9H027

    Protein attributes for ZCCHC9 Gene

    Size:
    271 amino acids
    Molecular mass:
    30477 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZCCHC9 Gene

Proteomics data for ZCCHC9 Gene at MOPED

Post-translational modifications for ZCCHC9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZCCHC9 Gene

No data available for DME Specific Peptides for ZCCHC9 Gene

Domains & Families for ZCCHC9 Gene

Protein Domains for ZCCHC9 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZCCHC9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N567

UniProtKB/Swiss-Prot:

ZCHC9_HUMAN :
  • Contains 4 CCHC-type zinc fingers.
Similarity:
  • Contains 4 CCHC-type zinc fingers.
genes like me logo Genes that share domains with ZCCHC9: view

Function for ZCCHC9 Gene

Molecular function for ZCCHC9 Gene

UniProtKB/Swiss-Prot Function:
May down-regulate transcription mediated by NF-kappa-B and the serum response element.
genes like me logo Genes that share phenotypes with ZCCHC9: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZCCHC9 Gene

Localization for ZCCHC9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZCCHC9 Gene

Nucleus, nucleolus. Nucleus. Note=Expressed throughout the nucleus and concentrated mainly in the nucleolus. {ECO:0000269 PubMed:18721783}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZCCHC9 Gene COMPARTMENTS Subcellular localization image for ZCCHC9 gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1
golgi apparatus 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for ZCCHC9 Gene

Pathways & Interactions for ZCCHC9 Gene

SuperPathways for ZCCHC9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZCCHC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010923 negative regulation of phosphatase activity IDA 19389623
genes like me logo Genes that share ontologies with ZCCHC9: view

No data available for Pathways by source and SIGNOR curated interactions for ZCCHC9 Gene

Drugs & Compounds for ZCCHC9 Gene

No Compound Related Data Available

Transcripts for ZCCHC9 Gene

Unigene Clusters for ZCCHC9 Gene

Zinc finger, CCHC domain containing 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC9 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b
SP1: - - - -
SP2:
SP3: - - - - -
SP4:
SP5: - - - - -
SP6: -
SP7: - -
SP8:

Relevant External Links for ZCCHC9 Gene

GeneLoc Exon Structure for
ZCCHC9
ECgene alternative splicing isoforms for
ZCCHC9

Expression for ZCCHC9 Gene

mRNA expression in normal human tissues for ZCCHC9 Gene

Protein differential expression in normal tissues from HIPED for ZCCHC9 Gene

This gene is overexpressed in Lung (67.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZCCHC9 Gene



SOURCE GeneReport for Unigene cluster for ZCCHC9 Gene Hs.15536

genes like me logo Genes that share expression patterns with ZCCHC9: view

Protein tissue co-expression partners for ZCCHC9 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZCCHC9 Gene

Orthologs for ZCCHC9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZCCHC9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZCCHC9 35
  • 91.02 (n)
  • 92.25 (a)
-- 36
  • 79 (a)
OneToMany
ZCCHC9 36
  • 93 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ZCCHC9 35
  • 90.77 (n)
  • 92.99 (a)
ZCCHC9 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zcchc9 35
  • 82.9 (n)
  • 83.39 (a)
Zcchc9 16
Zcchc9 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZCCHC9 35
  • 99.75 (n)
  • 99.26 (a)
ZCCHC9 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zcchc9 35
  • 82.9 (n)
  • 84.13 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 81 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ZCCHC9 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZCCHC9 35
  • 67.8 (n)
  • 67.66 (a)
ZCCHC9 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZCCHC9 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11804 35
zcchc9 35
  • 63.21 (n)
  • 61.41 (a)
zebrafish
(Danio rerio)
Actinopterygii zcchc9 35
  • 57.67 (n)
  • 53.17 (a)
zgc56467 35
zcchc9 36
  • 53 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13811 35
worm
(Caenorhabditis elegans)
Secernentea F07E5.5 36
  • 22 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4394 35
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC683.02c 35
  • 52.07 (n)
  • 45.75 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToOne
Species with no ortholog for ZCCHC9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZCCHC9 Gene

ENSEMBL:
Gene Tree for ZCCHC9 (if available)
TreeFam:
Gene Tree for ZCCHC9 (if available)

Paralogs for ZCCHC9 Gene

Pseudogenes.org Pseudogenes for ZCCHC9 Gene

genes like me logo Genes that share paralogs with ZCCHC9: view

No data available for Paralogs for ZCCHC9 Gene

Variants for ZCCHC9 Gene

Sequence variations from dbSNP and Humsavar for ZCCHC9 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs16878594 - 81,304,800(+) AGAGA(C/G/T)CCTTG intron-variant, reference, missense
rs924456 -- 81,310,129(-) AGTGA(A/G)AGCCA intron-variant
rs766877 -- 81,311,849(-) AATGT(A/G)ATAAT intron-variant
rs955948 -- 81,312,447(+) TATTC(A/T)TATCA intron-variant
rs1055383 -- 81,308,611(+) CCCGC(C/T)GCCCT reference, synonymous-codon, utr-variant-5-prime

Variation tolerance for ZCCHC9 Gene

Residual Variation Intolerance Score: 86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.52; 64.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZCCHC9 Gene

HapMap Linkage Disequilibrium report
ZCCHC9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZCCHC9 Gene

Disorders for ZCCHC9 Gene

Relevant External Links for ZCCHC9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZCCHC9

No disorders were found for ZCCHC9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZCCHC9 Gene

Publications for ZCCHC9 Gene

  1. A nuclear localized protein ZCCHC9 is expressed in cerebral cortex and suppresses the MAPK signal pathway. (PMID: 18721783) Zhou A. … Zhang J. (J Genet Genomics 2008) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  4. Docking motif-guided mapping of the interactome of protein phosphatase-1. (PMID: 19389623) Hendrickx A. … Bollen M. (Chem. Biol. 2009) 3
  5. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 3

Products for ZCCHC9 Gene

Sources for ZCCHC9 Gene

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