Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZCCHC8 Gene

protein-coding   GIFtS: 49
GCID: GC12M122958

Zinc Finger, CCHC Domain Containing 8

  Search for ZCCHC8
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger, CCHC Domain Containing 81 2
Zinc Finger CCHC Domain-Containing Protein 82

External Ids:    HGNC: 252651   Entrez Gene: 555962   Ensembl: ENSG000000330307   UniProtKB: Q6NZY43   

Export aliases for ZCCHC8 gene to outside databases

Previous GC identifers: GC12M121395 GC12M121482 GC12M119918


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZCCHC8 Gene: 
ZCCHC8 (zinc finger, CCHC domain containing 8) is a protein-coding gene. GO annotations related to this gene include zinc ion binding and nucleic acid binding.

UniProtKB/Swiss-Prot: ZCHC8_HUMAN, Q6NZY4
Function: May be involved in pre-mRNA splicing

Gene Wiki entry for ZCCHC8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009755.19  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZCCHC8 gene promoter:
         Egr-2   HEN1   PPAR-gamma1   Lmo2   PPAR-gamma2   E4BP4   Evi-1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZCCHC8 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZCCHC8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZCCHC8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

ZCCHC8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZCCHC8 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M122958:  view genomic region     (about GC identifiers)

Start:
122,956,146 bp from pter      End:
122,985,543 bp from pter
Size:
29,398 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZCHC8_HUMAN, Q6NZY4 (See protein sequence)
Recommended Name: Zinc finger CCHC domain-containing protein 8  
Size: 707 amino acids; 78577 Da
Subunit: Identified in the spliceosome C complex
Secondary accessions: Q7L2P6 Q8N2K5 Q96SK7 Q9NSS2 Q9NSS3
Alternative splicing: 2 isoforms:  Q6NZY4-1   Q6NZY4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZCCHC8: NX_Q6NZY4

Explore proteomics data for ZCCHC8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6NZY4

  • ZCCHC8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZCCHC8 Protein Expression
    REFSEQ proteins: NP_060082.2  
    ENSEMBL proteins: 
     ENSP00000441423   ENSP00000438993   ENSP00000440028   ENSP00000443818   ENSP00000441112  
     ENSP00000437578   ENSP00000440234   ENSP00000337313  

    Human Recombinant Protein Products for ZCCHC8: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ZCCHC8
    OriGene Protein Over-expression Lysate for ZCCHC8
    OriGene MassSpec for ZCCHC8 
    OriGene Custom Protein Services for ZCCHC8
    GenScript Custom Purified and Recombinant Proteins Services for ZCCHC8
    Novus Biologicals ZCCHC8 Protein
    Novus Biologicals ZCCHC8 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZCCHC8 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0071013catalytic step 2 spliceosome IDA11991638

    ZCCHC8 for ontologies           About GeneDecksing



    ZCCHC8 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ZCCHC8
    GenScript Custom Superior Antibodies Services for ZCCHC8
    Novus Biologicals ZCCHC8 Antibodies
    Abcam antibodies for ZCCHC8
    Cloud-Clone Corp. Antibodies for ZCCHC8 
    Search ThermoFisher Antibodies for ZCCHC8
    LSBio Antibodies in human, mouse, rat for ZCCHC8 

    Assay Products for ZCCHC8: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ZCCHC8
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ZCCHC8
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ZCCHC8 
    Cloud-Clone Corp. CLIAs for ZCCHC8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZCCHC: Zinc fingers, CCHC domain containing

    2 InterPro protein domains:
     IPR006568 PSP
     IPR001878 Znf_CCHC

    Graphical View of Domain Structure for InterPro Entry Q6NZY4

    ProtoNet protein and cluster: Q6NZY4

    2 Blocks protein domains:
    IPB001878 C2HC-type zinc-finger signature
    IPB006568 PSP


    UniProtKB/Swiss-Prot: ZCHC8_HUMAN, Q6NZY4
    Similarity: Belongs to the ZCCHC8 family
    Similarity: Contains 1 CCHC-type zinc finger


    ZCCHC8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZCHC8_HUMAN, Q6NZY4
    Function: May be involved in pre-mRNA splicing

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0005515protein binding IPI17525332
    GO:0008270zinc ion binding IEA--
         
    ZCCHC8 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZCCHC8 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZCCHC8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZCCHC8 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZCCHC8 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZCCHC8
    8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate ZCCHC8 (see all 64):
    hsa-miR-548j hsa-miR-579 hsa-miR-607 hsa-miR-376a* hsa-miR-3613-3p hsa-miR-29a* hsa-miR-548a-5p hsa-miR-30b*
    SwitchGear 3'UTR luciferase reporter plasmidZCCHC8 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZCCHC8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZCCHC8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ZCCHC8
    Sirion Biotech Customized adenovirus for overexpression of ZCCHC8

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ZCCHC8 (see all 7)
    OriGene ORF clones in mouse, rat for ZCCHC8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZCCHC8 (NM_017612)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZCCHC8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZCCHC8
    Sirion Biotech Customized lentivirus for stable overexpression of ZCCHC8 
                         Customized lentivirus expression plasmids for stable overexpression of ZCCHC8 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ZCCHC8
    Search LifeMap BioReagents cell lines for ZCCHC8
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCCHC8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZCCHC8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/23 Interacting proteins for ZCCHC8 (Q6NZY41, 2, 3 ENSP000003373134) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRPF40AO754002, 3MINT-61872 MINT-61861 I2D: score=4 
    BRCA1P383981, 3, ENSP000003502834EBI-1263058,EBI-349905 I2D: score=2 STRING: ENSP00000350283
    ENSG00000206454Q018603I2D: score=1 
    ENSG00000229094Q018603I2D: score=1 
    ENSG00000230336Q018603I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome IC11991638

    ZCCHC8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZCCHC8 (ZCHC8)

    Search CenterWatch for drugs/clinical trials and news about ZCCHC8 / ZCHC8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZCCHC8 gene: 
    NM_017612.4  

    Unigene Cluster for ZCCHC8:

    Zinc finger, CCHC domain containing 8
    Hs.37706  [show with all ESTs]
    Unigene Representative Sequence: NM_017612
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000536306(uc001ucm.3 uc009zxq.3) ENST00000543897(uc009zxp.3)
    ENST00000538116(uc001ucl.3) ENST00000542892 ENST00000544054 ENST00000536663
    ENST00000546149 ENST00000540586 ENST00000538493 ENST00000336229(uc001ucn.3)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZCCHC8
    8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate ZCCHC8 (see all 64):
    hsa-miR-548j hsa-miR-579 hsa-miR-607 hsa-miR-376a* hsa-miR-3613-3p hsa-miR-29a* hsa-miR-548a-5p hsa-miR-30b*
    SwitchGear 3'UTR luciferase reporter plasmidZCCHC8 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZCCHC8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZCCHC8
    Clone
    Products:
         
    OriGene clones in human, mouse for ZCCHC8 (see all 7)
    OriGene ORF clones in mouse, rat for ZCCHC8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZCCHC8 (NM_017612)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZCCHC8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZCCHC8
    Sirion Biotech Customized lentivirus for stable overexpression of ZCCHC8 
                         Customized lentivirus expression plasmids for stable overexpression of ZCCHC8 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ZCCHC8
    OriGene qSTAR qPCR primer pairs in human, mouse for ZCCHC8
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZCCHC8
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZCCHC8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZCCHC8

    Additional mRNA sequence: 

    AK027702.1 AK074638.1 AK291174.1 BC017704.2 BC065918.1 

    9 DOTS entries:

    DT.97814830  DT.100781638  DT.306444  DT.95171065  DT.92426976  DT.100781636  DT.100781641  DT.100781640 
    DT.91944467 

    24/129 AceView cDNA sequences (see all 129):

    AA493394 AI337815 AW327884 AI378627 CA312333 BM681945 BX090586 AA946686 
    BC017704 AK074638 BU688269 CN481601 BC065918 AI092893 BQ224742 BI830236 
    BM987562 N71260 AI701924 BP351934 AL157433 AK027702 AI090552 AW327925 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC8 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^
    SP1:                          -     -                 -     -                                         -                                         -               
    SP2:                          -     -                 -     -                       -     -     -     -                                                         
    SP3:                          -     -                 -     -     -     -                                                                                       
    SP4:                          -     -                 -     -     -     -           -     -     -     -                                                         
    SP5:                                      -           -     -                                                                                                   

    ExUns: 16a · 16b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for ZCCHC8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZCCHC8 expression in normal human tissues (normalized intensities)      ZCCHC8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTCAATTTT
    ZCCHC8 Expression
    About this image


    ZCCHC8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/36 selected tissues (see all 36) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
             breast epithelium   
     
     Uterus (Reproductive System)    fully expand to see all 5 entries
             uterus, post-menopause ; glandular cells   
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             bone marrow cd34+   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Breast
             breast ; myoepithelial cells   
             breast epithelium   

    See ZCCHC8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZCCHC8

    SOURCE GeneReport for Unigene cluster: Hs.37706
        SABiosciences Custom PCR Arrays for ZCCHC8
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ZCCHC8
    OriGene qSTAR qPCR primer pairs in human, mouse for ZCCHC8
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZCCHC8
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZCCHC8
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZCCHC8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCCHC8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZCCHC8 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zcchc81 , 5 zinc finger, CCHC domain containing 81, 5 83.17(n)1
    81.28(a)1
      5 (63.14 cM)5
    706501  NM_027494.31  NP_081770.31 
     1236983025 
    chicken
    (Gallus gallus)
    Aves ZCCHC81 zinc finger, CCHC domain containing 8 70.18(n)
    68.42(a)
      416862  NM_001030662.1  NP_001025833.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZCCHC86
    zinc finger, CCHC domain containing 8
    58(a)
    1 ↔ 1
    GL343423.1(188503-208867)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.26472 Xenopus laevis transcribed sequence with weak similarity more 77.23(n)    CA788185.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.173302 Transcribed sequence with weak similarity to protein more 73.89(n)    CK027495.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG46221 CG4622 45(n)
    37.78(a)
      37919  NM_138085.3  NP_611929.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK632.116
    Y34D9A.76
    Protein Y34D9A.7
    25(a)
    24(a)
    many → 1
    many → 1
    III(9827910-9829720)
    I(1041484-1048246)


    ENSEMBL Gene Tree for ZCCHC8 (if available)
    TreeFam Gene Tree for ZCCHC8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/548 SNPs in ZCCHC8 are shown (see all 548)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1927281511,2
    --122955684(+) CAGCAC/GTTAAG 1 -- int10--------
    rs79625921,2
    C,F,H--122955727(+) ttagaT/Attact 1 -- int16Minor allele frequency- A:0.07NS EA WA 540
    rs1841299441,2
    --122955985(+) AGGGAA/CTAGTC 1 -- int10--------
    rs1501434581,2
    --122956020(+) TAAGAA/TCCACT 1 -- int10--------
    rs1146485771,2
    C,F--122956262(+) TTCTCT/GCTTTA 1 -- ut311Minor allele frequency- G:0.17WA 118
    rs1386208601,2
    --122956355(+) TTTCTA/GTTTTG 1 -- ut310--------
    rs1873559131,2
    --122956366(+) CTCCCC/TCTGTT 1 -- ut310--------
    rs1922163841,2
    --122956416(+) CAAGAC/TGATCT 1 -- ut310--------
    rs798627691,2
    F--122956550(+) TTTAAT/CTTTTA 1 -- ut311Minor allele frequency- C:0.02WA 118
    rs116087111,2
    C,A,H--122956842(+) CTCCCC/ACTCCC 1 -- ut312Minor allele frequency- A:0.25NA 4

    HapMap Linkage Disequilibrium report for ZCCHC8 (122956146 - 122985543 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZCCHC8:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv899570CNV Gain21882294


    Human Gene Mutation Database (HGMD): ZCCHC8
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZCCHC8
    DNA2.0 Custom Variant and Variant Library Synthesis for ZCCHC8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZCCHC8 for disorders           About MalaCards

    ZCCHC8 for disorders           About GeneDecksing


    Export disorders for ZCCHC8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZCCHC8 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with ZCCHC8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)1, 2 Matsuoka S.... Elledge S.J. (2007)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (2002)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    6. Zcchc8 is a glycogen synthase kinase-3 substrate that interacts with RNA-binding proteins. (PubMed id 16263084)1, 9 Gustafson M.P....Clurman B.E. (2005)
    7. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55596 HGNC: 25265 AceView: ZCCHC8 Ensembl:ENSG00000033030 euGenes: HUgn55596
    ECgene: ZCCHC8 H-InvDB: ZCCHC8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZCCHC8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZCCHC8 gene:
    Search GeneIP for patents involving ZCCHC8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ZCCHC8  
     OriGene qPCR primer pairs and template standards for ZCCHC8   OriGene Protein Over-expression Lysate for ZCCHC8  
     OriGene MassSpec something-or-other for ZCCHC8   OriGene clones in human, mouse for ZCCHC8  
     OriGene qSTAR qPCR primer pairs in human, mouse for ZCCHC8   OriGene Purified Protein for ZCCHC8  
     OriGene ORF clones in mouse, rat for ZCCHC8   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ZCCHC8   OriGene Custom Protein Services for ZCCHC8  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZCCHC8
     QIAGEN SeqTarget long-range PCR primers for resequencing ZCCHC8
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZCCHC8
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZCCHC8
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZCCHC8
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZCCHC8
     GenScript Custom Purified and Recombinant Proteins Services for ZCCHC8 GenScript cDNA clones with any tag delivered in your preferred vector for ZCCHC8
     GenScript Custom Assay Services for ZCCHC8 GenScript Custom Superior Antibodies Services for ZCCHC8
     GenScript Custom overexpressing Cell Line Services for ZCCHC8 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ZCCHC8 promoter
     Search Chromatin IP Primers for ZCCHC8
     RT2 qPCR Primer Assay in human, mouse, rat ZCCHC8
     Search GNC Networks for ZCCHC8
     SABiosciences Custom PCR Arrays for ZCCHC8
     Search Tocris compounds for ZCCHC8 (ZCHC8)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ZCCHC8 antibodies
     ZCCHC8 proteins
     ZCCHC8 lysates
     Antibodies for ZCCHC8
     See all of Abcam's Antibodies, Kits and Proteins for ZCCHC8
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ZCCHC8
     Antibodies for ZCCHC8
     ELISAs for ZCCHC8
     CLIAs for ZCCHC8
     Search LifeMap BioReagents cell lines for ZCCHC8
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCCHC8
     SwitchGear 3'UTR luciferase reporter plasmids for ZCCHC8
     SwitchGear Promoter luciferase reporter plasmids for ZCCHC8
     Search ThermoFisher Antibodies for ZCCHC8
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZCCHC8
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ZCCHC8
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZCCHC8
    Customized:
     lentivirus for stable overexpression of ZCCHC8
     lentivirus expression plasmids for stable overexpression of ZCCHC8
     adenovirus for overexpression of ZCCHC8
     LSBio Antibodies in human, mouse, rat for ZCCHC8
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ZCCHC8 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4