Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZCCHC8 Gene

Aliases for ZCCHC8 Gene

  • Zinc Finger CCHC-Type Containing 8 2 3 5
  • TRAMP-Like Complex RNA-Binding Factor ZCCHC8 4

External Ids for ZCCHC8 Gene

Previous GeneCards Identifiers for ZCCHC8 Gene

  • GC12M121395
  • GC12M121482
  • GC12M122958
  • GC12M119918

Summaries for ZCCHC8 Gene

GeneCards Summary for ZCCHC8 Gene

ZCCHC8 (Zinc Finger CCHC-Type Containing 8) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for ZCCHC8 Gene

  • May be involved in pre-mRNA splicing.

Gene Wiki entry for ZCCHC8 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCCHC8 Gene

Genomics for ZCCHC8 Gene

Regulatory Elements for ZCCHC8 Gene

Enhancers for ZCCHC8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F121657 1.2 Ensembl ENCODE 124 +842.1 842073 3.6 HDGF PKNOX1 ARNT CREB3L1 SIN3A ZNF2 ZNF766 ZNF302 ZNF548 ZNF263 ZCCHC8 SETD1B KNTC1 ANAPC5 ENSG00000272849 PSMD9 LINC01089 MIR4700 ENSG00000258435 ENSG00000201945
GH12F122919 0.6 ENCODE 102.8 -418.9 -418934 1.5 ZFP64 ZNF493 ZEB1 ZNF155 ZNF121 ZNF138 ZNF354C KLF7 FOS ZNF202 EIF2B1 ZCCHC8 LOC101927415 ATP6V0A2 ENSG00000235423 KNTC1 TCTN2 C12orf65 KMT5A TMED2
GH12F122265 0.2 ENCODE 55.4 +234.7 234711 2.6 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 ZCCHC8 KNTC1 PSMD9 SETD1B ANAPC5 ENSG00000272849 ENSG00000235423 C12orf65 LOC101928346 LINC01089
GH12F123049 1.2 Ensembl ENCODE 45.9 -549.3 -549338 2.7 ATF1 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF121 GLIS2 ZNF766 EIF2B1 ZCCHC8 LOC101927415 ENSG00000235423 TCTN2 C12orf65 ATP6V0A2 KNTC1 PITPNM2 KMT5A
GH12F121887 1.2 ENCODE 45.8 +612.0 611982 2.3 CREB3L1 MLX FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 TBX21 MEF2D ZCCHC8 SETD1B KNTC1 ENSG00000272849 PSMD9 IL31 ENSG00000258435 ENSG00000201945 ENSG00000223538 ENSG00000256963
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZCCHC8 on UCSC Golden Path with GeneCards custom track

Promoters for ZCCHC8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ZCCHC8 Gene

122,471,599 bp from pter
122,501,073 bp from pter
29,475 bases
Minus strand

Genomic View for ZCCHC8 Gene

Genes around ZCCHC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZCCHC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZCCHC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCCHC8 Gene

Proteins for ZCCHC8 Gene

  • Protein details for ZCCHC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger CCHC domain-containing protein 8
    Protein Accession:
    Secondary Accessions:
    • Q7L2P6
    • Q8N2K5
    • Q96SK7
    • Q9NSS2
    • Q9NSS3

    Protein attributes for ZCCHC8 Gene

    707 amino acids
    Molecular mass:
    78577 Da
    Quaternary structure:
    • Component of a nuclear TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of a helicase (SKIV2L2/MTR4), an oligadenylate polymerase (PAPD5 or PAPD7), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes. Identified in the spliceosome C complex.

    Alternative splice isoforms for ZCCHC8 Gene


neXtProt entry for ZCCHC8 Gene

Post-translational modifications for ZCCHC8 Gene

  • Ubiquitination at Lys 363
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZCCHC8 Gene

Domains & Families for ZCCHC8 Gene

Protein Domains for ZCCHC8 Gene

Suggested Antigen Peptide Sequences for ZCCHC8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ZCCHC8 family.
  • Contains 1 CCHC-type zinc finger.
  • Belongs to the ZCCHC8 family.
  • Contains 1 CCHC-type zinc finger.
genes like me logo Genes that share domains with ZCCHC8: view

Function for ZCCHC8 Gene

Molecular function for ZCCHC8 Gene

UniProtKB/Swiss-Prot Function:
May be involved in pre-mRNA splicing.

Gene Ontology (GO) - Molecular Function for ZCCHC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 17525332
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZCCHC8: view

Animal Model Products

miRNA for ZCCHC8 Gene

miRTarBase miRNAs that target ZCCHC8

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZCCHC8 Gene

Localization for ZCCHC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZCCHC8 Gene

Nucleus, nucleoplasm. Note=Excluded from nucleolus.

Subcellular locations from

Jensen Localization Image for ZCCHC8 Gene COMPARTMENTS Subcellular localization image for ZCCHC8 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZCCHC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IEA --
GO:0005681 spliceosomal complex IEA --
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with ZCCHC8: view

Pathways & Interactions for ZCCHC8 Gene

SuperPathways for ZCCHC8 Gene

No Data Available

Interacting Proteins for ZCCHC8 Gene

Gene Ontology (GO) - Biological Process for ZCCHC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with ZCCHC8: view

No data available for Pathways by source and SIGNOR curated interactions for ZCCHC8 Gene

Transcripts for ZCCHC8 Gene

Unigene Clusters for ZCCHC8 Gene

Zinc finger, CCHC domain containing 8:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - - -
SP5: - - -
SP6: - -
SP8: - -

ExUns: 16a · 16b

Relevant External Links for ZCCHC8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZCCHC8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZCCHC8 Gene

Protein differential expression in normal tissues from HIPED for ZCCHC8 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.8) and Lymph node (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZCCHC8 Gene

Protein tissue co-expression partners for ZCCHC8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZCCHC8 Gene:


SOURCE GeneReport for Unigene cluster for ZCCHC8 Gene:

genes like me logo Genes that share expression patterns with ZCCHC8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZCCHC8 Gene

Orthologs for ZCCHC8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZCCHC8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZCCHC8 34 35
  • 98.83 (n)
(Canis familiaris)
Mammalia ZCCHC8 34 35
  • 88.18 (n)
(Bos Taurus)
Mammalia ZCCHC8 34 35
  • 87.23 (n)
(Mus musculus)
Mammalia Zcchc8 34 16 35
  • 82.46 (n)
(Ornithorhynchus anatinus)
Mammalia ZCCHC8 35
  • 74 (a)
(Monodelphis domestica)
Mammalia ZCCHC8 35
  • 71 (a)
(Gallus gallus)
Aves ZCCHC8 34 35
  • 70.5 (n)
(Anolis carolinensis)
Reptilia ZCCHC8 35
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zcchc8 34
  • 64.58 (n)
Str.16750 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.2647 34
(Danio rerio)
Actinopterygii zcchc8 34 35
  • 54.73 (n)
Dr.17330 34
fruit fly
(Drosophila melanogaster)
Insecta CG4622 35
  • 29 (a)
(Caenorhabditis elegans)
Secernentea Y34D9A.7 35
  • 25 (a)
ZK632.11 35
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
Species where no ortholog for ZCCHC8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZCCHC8 Gene

Gene Tree for ZCCHC8 (if available)
Gene Tree for ZCCHC8 (if available)

Paralogs for ZCCHC8 Gene

No data available for Paralogs for ZCCHC8 Gene

Variants for ZCCHC8 Gene

Sequence variations from dbSNP and Humsavar for ZCCHC8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs771416498 Uncertain significance 122,474,272(+) CCTCC(A/G)TATCT nc-transcript-variant, reference, missense
rs1063155 -- 122,473,607(-) TCACG(C/G)CATTT nc-transcript-variant, reference, missense
rs10642986 -- 122,497,998(+) CAAAA(-/CAAA)ACAAA intron-variant
rs10773208 -- 122,485,609(+) GGATT(C/T)CTAGC intron-variant
rs10846968 -- 122,475,355(+) TTGTT(C/T)TCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZCCHC8 Gene

Variant ID Type Subtype PubMed ID
esv3630977 CNV gain 21293372
nsv1113530 CNV deletion 24896259
nsv1134272 CNV deletion 24896259

Variation tolerance for ZCCHC8 Gene

Gene Damage Index Score: 2.50; 43.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZCCHC8 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZCCHC8 Gene

Disorders for ZCCHC8 Gene

Relevant External Links for ZCCHC8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZCCHC8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZCCHC8 Gene

Publications for ZCCHC8 Gene

  1. Interaction profiling identifies the human nuclear exosome targeting complex. (PMID: 21855801) Lubas M. … Jensen T.H. (Mol. Cell 2011) 2 3 4 64
  2. Zcchc8 is a glycogen synthase kinase-3 substrate that interacts with RNA-binding proteins. (PMID: 16263084) Gustafson M.P. … Clurman B.E. (Biochem. Biophys. Res. Commun. 2005) 2 3 22 64
  3. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PMID: 17525332) Matsuoka S. … Elledge S.J. (Science 2007) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ZCCHC8 Gene

Sources for ZCCHC8 Gene

Loading form....