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Aliases for ZCCHC8 Gene

Aliases for ZCCHC8 Gene

  • Zinc Finger CCHC-Type Containing 8 2 3
  • TRAMP-Like Complex RNA-Binding Factor ZCCHC8 4
  • Zinc Finger, CCHC Domain Containing 8 5

External Ids for ZCCHC8 Gene

Previous GeneCards Identifiers for ZCCHC8 Gene

  • GC12M121395
  • GC12M121482
  • GC12M122958
  • GC12M119918

Summaries for ZCCHC8 Gene

GeneCards Summary for ZCCHC8 Gene

ZCCHC8 (Zinc Finger CCHC-Type Containing 8) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for ZCCHC8 Gene

  • May be involved in pre-mRNA splicing.

Gene Wiki entry for ZCCHC8 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCCHC8 Gene

Genomics for ZCCHC8 Gene

Regulatory Elements for ZCCHC8 Gene

Enhancers for ZCCHC8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZCCHC8 on UCSC Golden Path with GeneCards custom track

Promoters for ZCCHC8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZCCHC8 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZCCHC8 Gene

122,471,599 bp from pter
122,501,073 bp from pter
29,475 bases
Minus strand

Genomic View for ZCCHC8 Gene

Genes around ZCCHC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZCCHC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZCCHC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCCHC8 Gene

Proteins for ZCCHC8 Gene

  • Protein details for ZCCHC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger CCHC domain-containing protein 8
    Protein Accession:
    Secondary Accessions:
    • Q7L2P6
    • Q8N2K5
    • Q96SK7
    • Q9NSS2
    • Q9NSS3

    Protein attributes for ZCCHC8 Gene

    707 amino acids
    Molecular mass:
    78577 Da
    Quaternary structure:
    • Component of a nuclear TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of an helicase (SKIV2L2/MTR4), an oligadenylate polymerase (PAPD5 or PAPD7), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes. Identified in the spliceosome C complex.

    Alternative splice isoforms for ZCCHC8 Gene


neXtProt entry for ZCCHC8 Gene

Proteomics data for ZCCHC8 Gene at MOPED

Post-translational modifications for ZCCHC8 Gene

  • Ubiquitination at Lys 363
  • Modification sites at PhosphoSitePlus

Other Protein References for ZCCHC8 Gene

No data available for DME Specific Peptides for ZCCHC8 Gene

Domains & Families for ZCCHC8 Gene

Gene Families for ZCCHC8 Gene

Protein Domains for ZCCHC8 Gene

Suggested Antigen Peptide Sequences for ZCCHC8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ZCCHC8 family.
  • Contains 1 CCHC-type zinc finger.
  • Belongs to the ZCCHC8 family.
  • Contains 1 CCHC-type zinc finger.
genes like me logo Genes that share domains with ZCCHC8: view

Function for ZCCHC8 Gene

Molecular function for ZCCHC8 Gene

UniProtKB/Swiss-Prot Function:
May be involved in pre-mRNA splicing.

Gene Ontology (GO) - Molecular Function for ZCCHC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ZCCHC8: view

Animal Model Products

miRNA for ZCCHC8 Gene

miRTarBase miRNAs that target ZCCHC8

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZCCHC8 Gene

Localization for ZCCHC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZCCHC8 Gene

Nucleus, nucleoplasm. Note=Excluded from nucleolus.

Subcellular locations from

Jensen Localization Image for ZCCHC8 Gene COMPARTMENTS Subcellular localization image for ZCCHC8 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZCCHC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IEA --
genes like me logo Genes that share ontologies with ZCCHC8: view

Pathways & Interactions for ZCCHC8 Gene

SuperPathways for ZCCHC8 Gene

No Data Available

Interacting Proteins for ZCCHC8 Gene

Gene Ontology (GO) - Biological Process for ZCCHC8 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZCCHC8 Gene

Drugs & Compounds for ZCCHC8 Gene

No Compound Related Data Available

Transcripts for ZCCHC8 Gene

Unigene Clusters for ZCCHC8 Gene

Zinc finger, CCHC domain containing 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - - -
SP5: - - -
SP6: - -
SP8: - -

ExUns: 16a · 16b

Relevant External Links for ZCCHC8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZCCHC8 Gene

mRNA expression in normal human tissues for ZCCHC8 Gene

Protein differential expression in normal tissues from HIPED for ZCCHC8 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.8) and Lymph node (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ZCCHC8 Gene

SOURCE GeneReport for Unigene cluster for ZCCHC8 Gene Hs.37706

genes like me logo Genes that share expression patterns with ZCCHC8: view

Protein tissue co-expression partners for ZCCHC8 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZCCHC8 Gene

Orthologs for ZCCHC8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZCCHC8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZCCHC8 35
  • 87.23 (n)
  • 86.81 (a)
  • 87 (a)
(Canis familiaris)
Mammalia ZCCHC8 35
  • 88.18 (n)
  • 87.38 (a)
  • 87 (a)
(Mus musculus)
Mammalia Zcchc8 35
  • 82.46 (n)
  • 80.43 (a)
Zcchc8 16
Zcchc8 36
  • 81 (a)
(Pan troglodytes)
Mammalia ZCCHC8 35
  • 98.83 (n)
  • 98.33 (a)
  • 99 (a)
(Monodelphis domestica)
Mammalia ZCCHC8 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia ZCCHC8 36
  • 74 (a)
(Gallus gallus)
Aves ZCCHC8 35
  • 70.5 (n)
  • 68.78 (a)
  • 66 (a)
(Anolis carolinensis)
Reptilia ZCCHC8 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16750 35
zcchc8 35
  • 64.58 (n)
  • 60.8 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2647 35
(Danio rerio)
Actinopterygii Dr.17330 35
zcchc8 35
  • 54.73 (n)
  • 49.33 (a)
zcchc8 36
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4622 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea Y34D9A.7 36
  • 25 (a)
ZK632.11 36
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
Species with no ortholog for ZCCHC8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZCCHC8 Gene

Gene Tree for ZCCHC8 (if available)
Gene Tree for ZCCHC8 (if available)

Paralogs for ZCCHC8 Gene

No data available for Paralogs for ZCCHC8 Gene

Variants for ZCCHC8 Gene

Sequence variations from dbSNP and Humsavar for ZCCHC8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1063155 - 122,473,607(-) TCACG(C/G)CATTT downstream-variant-500B, reference, missense
rs2062489 -- 122,494,435(+) acatg(A/C)ctgta intron-variant
rs7294365 -- 122,488,357(+) gaatt(C/T)ttcat intron-variant
rs10846968 -- 122,475,355(+) TTGTT(C/T)TCTCT intron-variant
rs10846978 -- 122,480,161(+) TCACA(C/T)GATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZCCHC8 Gene

Variant ID Type Subtype PubMed ID
nsv899570 CNV Gain 21882294

Variation tolerance for ZCCHC8 Gene

Gene Damage Index Score: 2.50; 43.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZCCHC8 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZCCHC8 Gene

Disorders for ZCCHC8 Gene

Relevant External Links for ZCCHC8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZCCHC8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZCCHC8 Gene

Publications for ZCCHC8 Gene

  1. Interaction profiling identifies the human nuclear exosome targeting complex. (PMID: 21855801) Lubas M. … Jensen T.H. (Mol. Cell 2011) 2 3 4 67
  2. Zcchc8 is a glycogen synthase kinase-3 substrate that interacts with RNA-binding proteins. (PMID: 16263084) Gustafson M.P. … Clurman B.E. (Biochem. Biophys. Res. Commun. 2005) 2 3 23
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for ZCCHC8 Gene

Sources for ZCCHC8 Gene