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ZCCHC8 Gene

protein-coding   GIFtS: 51
GCID: GC12M122958

Zinc Finger, CCHC Domain Containing 8

  Search for ZCCHC8
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, CCHC Domain Containing 81 2
TRAMP-Like Complex RNA-Binding Factor ZCCHC82 3
Zinc Finger CCHC Domain-Containing Protein 82

External Ids:    HGNC: 252651   Entrez Gene: 555962   Ensembl: ENSG000000330307   UniProtKB: Q6NZY43   

Export aliases for ZCCHC8 gene to outside databases

Previous GC identifers: GC12M121395 GC12M121482 GC12M119918


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZCCHC8 Gene:
ZCCHC8 (zinc finger, CCHC domain containing 8) is a protein-coding gene. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot: ZCHC8_HUMAN, Q6NZY4
Function: May be involved in pre-mRNA splicing

Gene Wiki entry for ZCCHC8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZCCHC8 gene promoter:
         Egr-2   HEN1   PPAR-gamma1   Lmo2   PPAR-gamma2   E4BP4   Evi-1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZCCHC8 promoter sequence
   Search Chromatin IP Primers for ZCCHC8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZCCHC8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

ZCCHC8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZCCHC8 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M122958:  view genomic region     (about GC identifiers)

Start:
122,956,146 bp from pter      End:
122,985,543 bp from pter
Size:
29,398 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZCHC8_HUMAN, Q6NZY4 (See protein sequence)
Recommended Name: Zinc finger CCHC domain-containing protein 8  
Size: 707 amino acids; 78577 Da
Subunit: Component of a nuclear TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of an
helicase (SKIV2L2/MTR4), an oligadenylate polymerase (PAPD5 or PAPD7), and a substrate specific RNA-binding
factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with
nuclear, or nucleolar RNA exosomes. Identified in the spliceosome C complex
Secondary accessions: Q7L2P6 Q8N2K5 Q96SK7 Q9NSS2 Q9NSS3
Alternative splicing: 2 isoforms:  Q6NZY4-1   Q6NZY4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZCCHC8: NX_Q6NZY4

Explore proteomics data for ZCCHC8 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys363
  • Modification sites at PhosphoSitePlus

  • See ZCCHC8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060082.2  
    ENSEMBL proteins: 
     ENSP00000441423   ENSP00000438993   ENSP00000440028   ENSP00000443818   ENSP00000441112  
     ENSP00000437578   ENSP00000440234   ENSP00000337313  

    ZCCHC8 Human Recombinant Protein Products:

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    Novus Biologicals ZCCHC8 Protein
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    Cloud-Clone Corp. Proteins for ZCCHC8

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZCCHC: Zinc fingers, CCHC domain containing

    2 InterPro protein domains:
     IPR006568 PSP
     IPR001878 Znf_CCHC

    Graphical View of Domain Structure for InterPro Entry Q6NZY4

    ProtoNet protein and cluster: Q6NZY4

    2 Blocks protein domains:
    IPB001878 C2HC-type zinc-finger signature
    IPB006568 PSP


    UniProtKB/Swiss-Prot: ZCHC8_HUMAN, Q6NZY4
    Similarity: Belongs to the ZCCHC8 family
    Similarity: Contains 1 CCHC-type zinc finger


    Find genes that share domains with ZCCHC8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZCHC8_HUMAN, Q6NZY4
    Function: May be involved in pre-mRNA splicing

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0005515protein binding IPI17525332
    GO:0008270zinc ion binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with ZCCHC8           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZCCHC8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZCCHC8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZCCHC8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZCCHC8

    miRNA
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    miRTarBase miRNAs that target ZCCHC8:
    hsa-mir-26b-5p (MIRT028967)

    Block miRNA regulation of human, mouse, rat ZCCHC8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZCCHC8 (see all 64):
    hsa-miR-548j hsa-miR-579 hsa-miR-607 hsa-miR-376a* hsa-miR-3613-3p hsa-miR-29a* hsa-miR-548a-5p hsa-miR-30b*
    SwitchGear 3'UTR luciferase reporter plasmidZCCHC8 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZCCHC8

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    GenScript: all cDNA clones in your preferred vector: ZCCHC8 (NM_017612)
    Sino Biological Human cDNA Clone for ZCCHC8
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZCCHC8

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCCHC8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZCHC8_HUMAN, Q6NZY4: Nucleus, nucleoplasm. Note=Excluded from nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0071013catalytic step 2 spliceosome IDA11991638

    Find genes that share ontologies with ZCCHC8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZCCHC8
    Interactions:

        Search GeneGlobe Interaction Network for ZCCHC8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for ZCCHC8 (Q6NZY41, 2, 3 ENSP000003373134) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRPF40AO754002, 3MINT-61872 MINT-61861 I2D: score=4 
    BRCA1P383981, 3, ENSP000003502834EBI-1263058,EBI-349905 I2D: score=2 STRING: ENSP00000350283
    ENSG00000206454Q018603I2D: score=1 
    ENSG00000229094Q018603I2D: score=1 
    ENSG00000230336Q018603I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome IC11991638

    Find genes that share ontologies with ZCCHC8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZCCHC8 (ZCHC8)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZCCHC8 gene: 
    NM_017612.4  

    Unigene Cluster for ZCCHC8:

    Zinc finger, CCHC domain containing 8
    Hs.37706  [show with all ESTs]
    Unigene Representative Sequence: NM_017612
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000536306(uc001ucm.3 uc009zxq.3) ENST00000543897(uc009zxp.3)
    ENST00000538116(uc001ucl.3) ENST00000542892 ENST00000544054 ENST00000536663
    ENST00000546149 ENST00000540586 ENST00000538493 ENST00000336229(uc001ucn.3)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZCCHC8 (see all 64):
    hsa-miR-548j hsa-miR-579 hsa-miR-607 hsa-miR-376a* hsa-miR-3613-3p hsa-miR-29a* hsa-miR-548a-5p hsa-miR-30b*
    SwitchGear 3'UTR luciferase reporter plasmidZCCHC8 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ZCCHC8
    Predesigned siRNA for gene silencing in human, mouse, rat ZCCHC8
    Clone
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    OriGene clones in human, mouse for ZCCHC8 (see all 6)
    OriGene ORF clones in mouse, rat for ZCCHC8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZCCHC8 (NM_017612)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZCCHC8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZCCHC8
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ZCCHC8
    OriGene qSTAR qPCR primer pairs in human, mouse for ZCCHC8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZCCHC8
      QuantiTect SYBR Green Assays in human, mouse, rat ZCCHC8
      QuantiFast Probe-based Assays in human, mouse, rat ZCCHC8

    Additional mRNA sequence: 

    AK027702.1 AK074638.1 AK291174.1 BC017704.2 BC065918.1 

    9 DOTS entries:

    DT.97814830  DT.100781638  DT.306444  DT.95171065  DT.92426976  DT.100781636  DT.100781641  DT.100781640 
    DT.91944467 

    Selected AceView cDNA sequences (see all 129):

    AL157433 AW327884 AW327925 AI654797 BQ230988 AW008380 AK027702 CA312333 
    AI090552 BC065918 AA626301 BX279716 BC017704 BM987562 N71260 AW327883 
    AI092893 CA418826 AI261251 AA447641 AI275182 AI701924 CN481601 BP351934 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC8 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^
    SP1:                          -     -                 -     -                                         -                                         -               
    SP2:                          -     -                 -     -                       -     -     -     -                                                         
    SP3:                          -     -                 -     -     -     -                                                                                       
    SP4:                          -     -                 -     -     -     -           -     -     -     -                                                         
    SP5:                                      -           -     -                                                                                                   

    ExUns: 16a · 16b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for ZCCHC8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZCCHC8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTCAATTTT
    ZCCHC8 Expression
    About this image


    ZCCHC8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    ZCCHC8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZCCHC8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.37706
        Custom PCR Arrays for ZCCHC8
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat ZCCHC8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCCHC8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZCCHC8 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zcchc81 , 5 zinc finger, CCHC domain containing 81, 5 82.46(n)1
    80.43(a)1
      5 (63.14 cM)5
    706501  NM_027494.31  NP_081770.31 
     1236983025 
    chicken
    (Gallus gallus)
    Aves ZCCHC81 zinc finger, CCHC domain containing 8 70.5(n)
    68.78(a)
      416862  NM_001030662.1  NP_001025833.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZCCHC86
    zinc finger, CCHC domain containing 8
    58(a)
    1 ↔ 1
    GL343423.1(188503-208867)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.26472 Xenopus laevis transcribed sequence with weak similarity more 77.23(n)    CA788185.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.173302 Transcribed sequence with weak similarity to protein more 73.89(n)    CK027495.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG46226
    --
    29(a)
    1 ↔ 1
    2R(20420897-20443759)
    worm
    (Caenorhabditis elegans)
    Secernentea Y34D9A.76
    ZK632.116
    Protein ZK632.11 (ZK632.11) mRNA, complete cds
    25(a)
    23(a)
    many → 1
    many → 1
    I(1041484-1048246) WBGene00021332
    III(9827915-9829720) WBGene00014018


    ENSEMBL Gene Tree for ZCCHC8 (if available)
    TreeFam Gene Tree for ZCCHC8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZCCHC8 (see all 548)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1927281511,2
    --122955684(+) CAGCAC/GTTAAG 1 -- int10--------
    rs79625921,2
    C,F,H--122955727(+) ttagaT/Attact 1 -- int16Minor allele frequency- A:0.07NS EA WA 540
    rs1841299441,2
    --122955985(+) AGGGAA/CTAGTC 1 -- int10--------
    rs1501434581,2
    --122956020(+) TAAGAA/TCCACT 1 -- int10--------
    rs1146485771,2
    C,F--122956262(+) TTCTCT/GCTTTA 1 -- ut311Minor allele frequency- G:0.17WA 118
    rs1386208601,2
    --122956355(+) TTTCTA/GTTTTG 1 -- ut310--------
    rs1873559131,2
    --122956366(+) CTCCCC/TCTGTT 1 -- ut310--------
    rs1922163841,2
    --122956416(+) CAAGAC/TGATCT 1 -- ut310--------
    rs798627691,2
    F--122956550(+) TTTAAT/CTTTTA 1 -- ut311Minor allele frequency- C:0.02WA 118
    rs116087111,2
    C,A,H--122956842(+) CTCCCC/ACTCCC 1 -- ut312Minor allele frequency- A:0.25NA 4

    HapMap Linkage Disequilibrium report for ZCCHC8 (122956146 - 122985543 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZCCHC8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899570CNV Gain21882294

    Human Gene Mutation Database (HGMD): ZCCHC8
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZCCHC8
    DNA2.0 Custom Variant and Variant Library Synthesis for ZCCHC8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ZCCHC8           About GenesLikeMe


    Export disorders for ZCCHC8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZCCHC8 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with ZCCHC8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)1, 2 Matsuoka S.... Elledge S.J. (Science 2007)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (RNA 2002)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. Zcchc8 is a glycogen synthase kinase-3 substrate that interacts with RNA-binding proteins. (PubMed id 16263084)1, 9 Gustafson M.P....Clurman B.E. (Biochem. Biophys. Res. Commun. 2005)
    7. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    8. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    9. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    10. Comparison of the yeast and human nuclear exosome complexes. (PubMed id 22817747)2 Sloan K.E.... Watkins N.J. (Biochem. Soc. Trans. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55596 HGNC: 25265 AceView: ZCCHC8 Ensembl:ENSG00000033030 euGenes: HUgn55596
    ECgene: ZCCHC8 H-InvDB: ZCCHC8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZCCHC8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZCCHC8 gene:
    Search GeneIP for patents involving ZCCHC8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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