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Aliases for ZCCHC8 Gene

Aliases for ZCCHC8 Gene

  • Zinc Finger, CCHC Domain Containing 8 2 3
  • TRAMP-Like Complex RNA-Binding Factor ZCCHC8 4

External Ids for ZCCHC8 Gene

Summaries for ZCCHC8 Gene

GeneCards Summary for ZCCHC8 Gene

ZCCHC8 (Zinc Finger, CCHC Domain Containing 8) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for ZCCHC8 Gene

  • May be involved in pre-mRNA splicing

Gene Wiki entry for ZCCHC8 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCCHC8 Gene

Genomics for ZCCHC8 Gene

Genomic Location for ZCCHC8 Gene

Start:
122,471,599 bp from pter
End:
122,501,073 bp from pter
Size:
29,475 bases
Orientation:
Minus strand

Genomic View for ZCCHC8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZCCHC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCCHC8 Gene

Regulatory Elements for ZCCHC8 Gene

Proteins for ZCCHC8 Gene

  • Protein details for ZCCHC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NZY4-ZCHC8_HUMAN
    Recommended name:
    Zinc finger CCHC domain-containing protein 8
    Protein Accession:
    Q6NZY4
    Secondary Accessions:
    • Q7L2P6
    • Q8N2K5
    • Q96SK7
    • Q9NSS2
    • Q9NSS3

    Protein attributes for ZCCHC8 Gene

    Size:
    707 amino acids
    Molecular mass:
    78577 Da
    Quaternary structure:
    • Component of a nuclear TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of an helicase (SKIV2L2/MTR4), an oligadenylate polymerase (PAPD5 or PAPD7), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes. Identified in the spliceosome C complex.

    Alternative splice isoforms for ZCCHC8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZCCHC8 Gene

Proteomics data for ZCCHC8 Gene at MOPED

Post-translational modifications for ZCCHC8 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys363

Other Protein References for ZCCHC8 Gene

No data available for DME Specific Peptides for ZCCHC8 Gene

Domains for ZCCHC8 Gene

Gene Families for ZCCHC8 Gene

HGNC:
  • ZCCHC :Zinc fingers, CCHC domain containing

Protein Domains for ZCCHC8 Gene

UniProtKB/Swiss-Prot:

ZCHC8_HUMAN
Family:
  • Belongs to the ZCCHC8 family.:
    • Q6NZY4
Similarity:
  • Contains 1 CCHC-type zinc finger.:
    • Q6NZY4
genes like me logo Genes that share domains with ZCCHC8: view

Function for ZCCHC8 Gene

Molecular function for ZCCHC8 Gene

UniProtKB/Swiss-Prot Function: May be involved in pre-mRNA splicing

Gene Ontology (GO) - Molecular Function for ZCCHC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17525332
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ZCCHC8: view

miRNA for ZCCHC8 Gene

miRTarBase miRNAs that target ZCCHC8

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZCCHC8 Gene

Localization for ZCCHC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZCCHC8 Gene

Nucleus, nucleoplasm. Note=Excluded from nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZCCHC8 Gene COMPARTMENTS Subcellular localization image for ZCCHC8 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZCCHC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with ZCCHC8: view

Pathways for ZCCHC8 Gene

SuperPathways for ZCCHC8 Gene

No Data Available

Interacting Proteins for ZCCHC8 Gene

Gene Ontology (GO) - Biological Process for ZCCHC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
genes like me logo Genes that share ontologies with ZCCHC8: view

No data available for Pathways by source for ZCCHC8 Gene

Transcripts for ZCCHC8 Gene

Unigene Clusters for ZCCHC8 Gene

Zinc finger, CCHC domain containing 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - - -
SP5: - - -
SP6: - -
SP7:
SP8: - -
SP9:

ExUns: 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for ZCCHC8 Gene

GeneLoc Exon Structure for
ZCCHC8
ECgene alternative splicing isoforms for
ZCCHC8

Expression for ZCCHC8 Gene

mRNA expression in normal human tissues for ZCCHC8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ZCCHC8 Gene

SOURCE GeneReport for Unigene cluster for ZCCHC8 Gene Hs.37706

genes like me logo Genes that share expressions with ZCCHC8: view

Orthologs for ZCCHC8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZCCHC8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZCCHC8 36
  • 98.83 (n)
  • 98.33 (a)
ZCCHC8 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZCCHC8 36
  • 87.23 (n)
  • 86.81 (a)
ZCCHC8 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZCCHC8 36
  • 88.18 (n)
  • 87.38 (a)
ZCCHC8 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zcchc8 36
  • 82.46 (n)
  • 80.43 (a)
Zcchc8 16
Zcchc8 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZCCHC8 37
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZCCHC8 37
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZCCHC8 36
  • 70.5 (n)
  • 68.78 (a)
ZCCHC8 37
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZCCHC8 37
  • 58 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2647 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16750 36
zcchc8 36
  • 64.58 (n)
  • 60.8 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.17330 36
zcchc8 36
  • 54.73 (n)
  • 49.33 (a)
zcchc8 37
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4622 37
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y34D9A.7 37
  • 25 (a)
OneToMany
ZK632.11 37
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 33 (a)
OneToOne
Species with no ortholog for ZCCHC8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZCCHC8 Gene

ENSEMBL:
Gene Tree for ZCCHC8 (if available)
TreeFam:
Gene Tree for ZCCHC8 (if available)

Paralogs for ZCCHC8 Gene

No data available for Paralogs for ZCCHC8 Gene

Variants for ZCCHC8 Gene

Sequence variations from dbSNP and Humsavar for ZCCHC8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1063155 - 122,473,607(-) TCACG(C/G)CATTT reference, missense
rs1473553 -- 122,500,510(+) AGAAA(G/T)CACTT intron-variant
rs2062489 -- 122,494,435(+) acatg(A/C)ctgta intron-variant
rs2936693 -- 122,498,178(-) TCCGT(C/T)TGAAA intron-variant
rs4039662 -- 122,491,022(+) AATAC(-/GTAC)ATAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZCCHC8 Gene

Variant ID Type Subtype PubMed ID
nsv899570 CNV Gain 21882294

Relevant External Links for ZCCHC8 Gene

HapMap Linkage Disequilibrium report
ZCCHC8
Human Gene Mutation Database (HGMD)
ZCCHC8

Disorders for ZCCHC8 Gene

No disorders were found for ZCCHC8 Gene.

No data available for UniProtKB/Swiss-Prot for ZCCHC8 Gene

Publications for ZCCHC8 Gene

  1. Interaction profiling identifies the human nuclear exosome targeting complex. (PMID: 21855801) Lubas M. … Jensen T.H. (Mol. Cell 2011) 2 3 4
  2. Zcchc8 is a glycogen synthase kinase-3 substrate that interacts with RNA-binding proteins. (PMID: 16263084) Gustafson M.P. … Clurman B.E. (Biochem. Biophys. Res. Commun. 2005) 2 3 23
  3. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica M.S. … Moore M.J. (RNA 2002) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ZCCHC8 Gene

Sources for ZCCHC8 Gene

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