Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZCCHC8 Gene

Aliases for ZCCHC8 Gene

  • Zinc Finger, CCHC Domain Containing 8 2 3
  • TRAMP-Like Complex RNA-Binding Factor ZCCHC8 4

External Ids for ZCCHC8 Gene

Previous GeneCards Identifiers for ZCCHC8 Gene

  • GC12M121395
  • GC12M121482
  • GC12M122958
  • GC12M119918

Summaries for ZCCHC8 Gene

GeneCards Summary for ZCCHC8 Gene

ZCCHC8 (Zinc Finger, CCHC Domain Containing 8) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for ZCCHC8 Gene

  • May be involved in pre-mRNA splicing

Gene Wiki entry for ZCCHC8 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCCHC8 Gene

Genomics for ZCCHC8 Gene

Regulatory Elements for ZCCHC8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZCCHC8 Gene

122,471,599 bp from pter
122,501,073 bp from pter
29,475 bases
Minus strand

Genomic View for ZCCHC8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZCCHC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCCHC8 Gene

Proteins for ZCCHC8 Gene

  • Protein details for ZCCHC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger CCHC domain-containing protein 8
    Protein Accession:
    Secondary Accessions:
    • Q7L2P6
    • Q8N2K5
    • Q96SK7
    • Q9NSS2
    • Q9NSS3

    Protein attributes for ZCCHC8 Gene

    707 amino acids
    Molecular mass:
    78577 Da
    Quaternary structure:
    • Component of a nuclear TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of an helicase (SKIV2L2/MTR4), an oligadenylate polymerase (PAPD5 or PAPD7), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes. Identified in the spliceosome C complex.

    Alternative splice isoforms for ZCCHC8 Gene


neXtProt entry for ZCCHC8 Gene

Proteomics data for ZCCHC8 Gene at MOPED

Post-translational modifications for ZCCHC8 Gene

  • Ubiquitination at Lys363
  • Modification sites at PhosphoSitePlus

Other Protein References for ZCCHC8 Gene

No data available for DME Specific Peptides for ZCCHC8 Gene

Domains for ZCCHC8 Gene

Gene Families for ZCCHC8 Gene

  • ZCCHC :Zinc fingers, CCHC domain containing

Protein Domains for ZCCHC8 Gene

Suggested Antigen Peptide Sequences for ZCCHC8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q6NZY4
  • Belongs to the ZCCHC8 family.
  • Contains 1 CCHC-type zinc finger.
genes like me logo Genes that share domains with ZCCHC8: view

Function for ZCCHC8 Gene

Molecular function for ZCCHC8 Gene

UniProtKB/Swiss-Prot Function: May be involved in pre-mRNA splicing

Gene Ontology (GO) - Molecular Function for ZCCHC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17525332
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ZCCHC8: view

Animal Model Products

CRISPR Products

miRNA for ZCCHC8 Gene

miRTarBase miRNAs that target ZCCHC8

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZCCHC8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZCCHC8 Gene

Localization for ZCCHC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZCCHC8 Gene

Nucleus, nucleoplasm. Note=Excluded from nucleolus.

Subcellular locations from

Jensen Localization Image for ZCCHC8 Gene COMPARTMENTS Subcellular localization image for ZCCHC8 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZCCHC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with ZCCHC8: view

Pathways for ZCCHC8 Gene

SuperPathways for ZCCHC8 Gene

No Data Available

Interacting Proteins for ZCCHC8 Gene

Gene Ontology (GO) - Biological Process for ZCCHC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
genes like me logo Genes that share ontologies with ZCCHC8: view

No data available for Pathways by source for ZCCHC8 Gene

Transcripts for ZCCHC8 Gene

Unigene Clusters for ZCCHC8 Gene

Zinc finger, CCHC domain containing 8:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZCCHC8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - - -
SP5: - - -
SP6: - -
SP8: - -

ExUns: 16a · 16b

Relevant External Links for ZCCHC8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZCCHC8 Gene

mRNA expression in normal human tissues for ZCCHC8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ZCCHC8 Gene

SOURCE GeneReport for Unigene cluster for ZCCHC8 Gene Hs.37706

genes like me logo Genes that share expressions with ZCCHC8: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZCCHC8 Gene

Orthologs for ZCCHC8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZCCHC8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZCCHC8 35
  • 98.83 (n)
  • 98.33 (a)
  • 99 (a)
(Bos Taurus)
Mammalia ZCCHC8 35
  • 87.23 (n)
  • 86.81 (a)
  • 87 (a)
(Canis familiaris)
Mammalia ZCCHC8 35
  • 88.18 (n)
  • 87.38 (a)
  • 87 (a)
(Mus musculus)
Mammalia Zcchc8 35
  • 82.46 (n)
  • 80.43 (a)
Zcchc8 16
Zcchc8 36
  • 81 (a)
(Monodelphis domestica)
Mammalia ZCCHC8 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia ZCCHC8 36
  • 74 (a)
(Gallus gallus)
Aves ZCCHC8 35
  • 70.5 (n)
  • 68.78 (a)
  • 66 (a)
(Anolis carolinensis)
Reptilia ZCCHC8 36
  • 58 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2647 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16750 35
zcchc8 35
  • 64.58 (n)
  • 60.8 (a)
(Danio rerio)
Actinopterygii Dr.17330 35
zcchc8 35
  • 54.73 (n)
  • 49.33 (a)
zcchc8 36
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4622 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea Y34D9A.7 36
  • 25 (a)
ZK632.11 36
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
Species with no ortholog for ZCCHC8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZCCHC8 Gene

Gene Tree for ZCCHC8 (if available)
Gene Tree for ZCCHC8 (if available)

Paralogs for ZCCHC8 Gene

No data available for Paralogs for ZCCHC8 Gene

Variants for ZCCHC8 Gene

Sequence variations from dbSNP and Humsavar for ZCCHC8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1063155 - 122,473,607(-) TCACG(C/G)CATTT reference, missense
rs1473553 -- 122,500,510(+) AGAAA(G/T)CACTT intron-variant
rs2062489 -- 122,494,435(+) acatg(A/C)ctgta intron-variant
rs2936693 -- 122,498,178(-) TCCGT(C/T)TGAAA intron-variant
rs4039662 -- 122,491,022(+) AATAC(-/GTAC)ATAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZCCHC8 Gene

Variant ID Type Subtype PubMed ID
nsv899570 CNV Gain 21882294

Relevant External Links for ZCCHC8 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZCCHC8 Gene

Disorders for ZCCHC8 Gene

No disorders were found for ZCCHC8 Gene.

No data available for UniProtKB/Swiss-Prot for ZCCHC8 Gene

Publications for ZCCHC8 Gene

  1. Interaction profiling identifies the human nuclear exosome targeting complex. (PMID: 21855801) Lubas M. … Jensen T.H. (Mol. Cell 2011) 2 3 4
  2. Zcchc8 is a glycogen synthase kinase-3 substrate that interacts with RNA-binding proteins. (PMID: 16263084) Gustafson M.P. … Clurman B.E. (Biochem. Biophys. Res. Commun. 2005) 2 3 23
  3. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica M.S. … Moore M.J. (RNA 2002) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ZCCHC8 Gene

Sources for ZCCHC8 Gene

Back to Top