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Aliases for ZCCHC8 Gene

Aliases for ZCCHC8 Gene

  • Zinc Finger CCHC-Type Containing 8 2 3 5
  • TRAMP-Like Complex RNA-Binding Factor ZCCHC8 4

External Ids for ZCCHC8 Gene

Previous GeneCards Identifiers for ZCCHC8 Gene

  • GC12M121395
  • GC12M121482
  • GC12M122958
  • GC12M119918

Summaries for ZCCHC8 Gene

Entrez Gene Summary for ZCCHC8 Gene

  • This gene encodes a scaffold protein which serves as an assessory factor to the nuclear RNA exosome complex. The encoded protein forms a trimeric human nuclear exosome targeting (NEXT) complex, together with hMTR4 and the RNA-binding factor RBM7 which promotes the exosomal degradation of non-coding promoter-upstream transcripts, enhancer RNAs and 3'-extended products of histone- and small nuclear RNA transcription. This complex is also thought to recruit the exosome to degrade intronic RNAs via its interaction with both the exosome and the spliceosome. It contains both an N-terminal zinc-knuckle domain and a C-terminal proline-rich domain. [provided by RefSeq, Apr 2017]

GeneCards Summary for ZCCHC8 Gene

ZCCHC8 (Zinc Finger CCHC-Type Containing 8) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for ZCCHC8 Gene

  • May be involved in pre-mRNA splicing.

Gene Wiki entry for ZCCHC8 Gene

Additional gene information for ZCCHC8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCCHC8 Gene

Genomics for ZCCHC8 Gene

Regulatory Elements for ZCCHC8 Gene

Enhancers for ZCCHC8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H121783 1.9 FANTOM5 ENCODE dbSUPER 72.6 +705.1 705081 24 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A NFYC MEF2D ZCCHC8 RSRC2 ENSG00000272849 PSMD9 SETD1B ANAPC5 KNTC1 LINC01089 HPD KDM2B
GH12H122919 1.2 ENCODE dbSUPER 113.8 -418.9 -418934 1 ZNF493 ZFP64 ZEB1 ZNF155 ZNF121 ZNF138 ZNF354C FOS KLF7 ZNF202 EIF2B1 RSRC2 DDX55 ZCCHC8 ENSG00000235423 ATP6V0A2 LOC101927415 C12orf65 TCTN2 OGFOD2
GH12H123231 1.4 ENCODE dbSUPER 53.3 -732.4 -732444 3 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 RSRC2 ZCCHC8 DDX55 EIF2B1 KNTC1 CDK2AP1 LOC101927415 MPHOSPH9 OGFOD2 C12orf65
GH12H121887 1.2 ENCODE 60.1 +612.0 611982 2 MLX FEZF1 DMAP1 YY1 ZNF143 SP3 MEF2D ZNF610 GLIS1 RCOR2 RSRC2 KNTC1 ZCCHC8 SETD1B ENSG00000272849 ANAPC5 PSMD9 LINC01089 SPPL3 IL31
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZCCHC8 on UCSC Golden Path with GeneCards custom track

Promoters for ZCCHC8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ZCCHC8 Gene

122,471,599 bp from pter
122,501,073 bp from pter
29,475 bases
Minus strand

Genomic View for ZCCHC8 Gene

Genes around ZCCHC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZCCHC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZCCHC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCCHC8 Gene

Proteins for ZCCHC8 Gene

  • Protein details for ZCCHC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger CCHC domain-containing protein 8
    Protein Accession:
    Secondary Accessions:
    • Q7L2P6
    • Q8N2K5
    • Q96SK7
    • Q9NSS2
    • Q9NSS3

    Protein attributes for ZCCHC8 Gene

    707 amino acids
    Molecular mass:
    78577 Da
    Quaternary structure:
    • Component of a nuclear TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of a helicase (SKIV2L2/MTR4), an oligadenylate polymerase (PAPD5 or PAPD7), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes. Identified in the spliceosome C complex.

    Three dimensional structures from OCA and Proteopedia for ZCCHC8 Gene

    Alternative splice isoforms for ZCCHC8 Gene


neXtProt entry for ZCCHC8 Gene

Post-translational modifications for ZCCHC8 Gene

  • Ubiquitination at isoforms=2363
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZCCHC8 Gene

Domains & Families for ZCCHC8 Gene

Gene Families for ZCCHC8 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for ZCCHC8 Gene

Suggested Antigen Peptide Sequences for ZCCHC8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ZCCHC8 family.
  • Belongs to the ZCCHC8 family.
genes like me logo Genes that share domains with ZCCHC8: view

Function for ZCCHC8 Gene

Molecular function for ZCCHC8 Gene

UniProtKB/Swiss-Prot Function:
May be involved in pre-mRNA splicing.

Phenotypes From GWAS Catalog for ZCCHC8 Gene

Gene Ontology (GO) - Molecular Function for ZCCHC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 16263084
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZCCHC8: view

Animal Model Products

CRISPR Products

miRNA for ZCCHC8 Gene

miRTarBase miRNAs that target ZCCHC8

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZCCHC8
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZCCHC8 Gene

Localization for ZCCHC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZCCHC8 Gene

Nucleus, nucleoplasm. Note=Excluded from nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZCCHC8 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZCCHC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 21855801
GO:0005654 nucleoplasm IEA,IDA 16263084
GO:0005681 spliceosomal complex IEA --
GO:0005730 NOT nucleolus IDA 21855801
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with ZCCHC8: view

Pathways & Interactions for ZCCHC8 Gene

SuperPathways for ZCCHC8 Gene

No Data Available

Interacting Proteins for ZCCHC8 Gene

Gene Ontology (GO) - Biological Process for ZCCHC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with ZCCHC8: view

No data available for Pathways by source and SIGNOR curated interactions for ZCCHC8 Gene

Drugs & Compounds for ZCCHC8 Gene

No Compound Related Data Available

Transcripts for ZCCHC8 Gene

Unigene Clusters for ZCCHC8 Gene

Zinc finger, CCHC domain containing 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZCCHC8
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - - -
SP5: - - -
SP6: - -
SP8: - -

ExUns: 16a · 16b

Relevant External Links for ZCCHC8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZCCHC8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZCCHC8 Gene

Protein differential expression in normal tissues from HIPED for ZCCHC8 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.8) and Lymph node (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZCCHC8 Gene

Protein tissue co-expression partners for ZCCHC8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZCCHC8 Gene:


SOURCE GeneReport for Unigene cluster for ZCCHC8 Gene:


Evidence on tissue expression from TISSUES for ZCCHC8 Gene

  • Nervous system(4.4)
  • Intestine(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with ZCCHC8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZCCHC8 Gene

Orthologs for ZCCHC8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZCCHC8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZCCHC8 33 34
  • 98.83 (n)
(Canis familiaris)
Mammalia ZCCHC8 33 34
  • 88.18 (n)
(Bos Taurus)
Mammalia ZCCHC8 33 34
  • 87.23 (n)
(Mus musculus)
Mammalia Zcchc8 33 16 34
  • 82.46 (n)
(Ornithorhynchus anatinus)
Mammalia ZCCHC8 34
  • 74 (a)
(Monodelphis domestica)
Mammalia ZCCHC8 34
  • 71 (a)
(Gallus gallus)
Aves ZCCHC8 33 34
  • 70.5 (n)
(Anolis carolinensis)
Reptilia ZCCHC8 34
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zcchc8 33
  • 64.58 (n)
Str.16750 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.2647 33
(Danio rerio)
Actinopterygii zcchc8 33 34
  • 54.73 (n)
Dr.17330 33
fruit fly
(Drosophila melanogaster)
Insecta CG4622 34
  • 29 (a)
(Caenorhabditis elegans)
Secernentea Y34D9A.7 34
  • 25 (a)
ZK632.11 34
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
Species where no ortholog for ZCCHC8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZCCHC8 Gene

Gene Tree for ZCCHC8 (if available)
Gene Tree for ZCCHC8 (if available)

Paralogs for ZCCHC8 Gene

No data available for Paralogs for ZCCHC8 Gene

Variants for ZCCHC8 Gene

Sequence variations from dbSNP and Humsavar for ZCCHC8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs771416498 Uncertain significance 122,474,272(+) CCTCC(A/G)TATCT nc-transcript-variant, reference, missense
rs1000032012 -- 122,478,462(+) ACTAA(A/C)CTTGC intron-variant
rs1000244126 -- 122,490,788(+) ATTGG(C/T)ATAAC intron-variant
rs1000520311 -- 122,497,430(+) CCAGC(G/T)ATTCG intron-variant
rs1000882888 -- 122,493,165(+) ACCAG(C/G)CTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZCCHC8 Gene

Variant ID Type Subtype PubMed ID
esv3630977 CNV gain 21293372
nsv1113530 CNV deletion 24896259
nsv1134272 CNV deletion 24896259

Variation tolerance for ZCCHC8 Gene

Gene Damage Index Score: 2.50; 43.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZCCHC8 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZCCHC8 Gene

Disorders for ZCCHC8 Gene

Relevant External Links for ZCCHC8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZCCHC8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZCCHC8 Gene

Publications for ZCCHC8 Gene

  1. Interaction profiling identifies the human nuclear exosome targeting complex. (PMID: 21855801) Lubas M … Jensen TH (Molecular cell 2011) 2 3 4 60
  2. Zcchc8 is a glycogen synthase kinase-3 substrate that interacts with RNA-binding proteins. (PMID: 16263084) Gustafson MP … Clurman BE (Biochemical and biophysical research communications 2005) 2 3 22 60
  3. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PMID: 17525332) Matsuoka S … Elledge SJ (Science (New York, N.Y.) 2007) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for ZCCHC8 Gene

Sources for ZCCHC8 Gene

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