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Aliases for ZCCHC7 Gene

Aliases for ZCCHC7 Gene

  • Zinc Finger CCHC-Type Containing 7 2 3
  • TRAMP-Like Complex RNA-Binding Factor ZCCHC7 3 4
  • Zinc Finger, CCHC Domain Containing 7 3 5
  • HSPC086 3
  • AIR1 3

External Ids for ZCCHC7 Gene

Previous GeneCards Identifiers for ZCCHC7 Gene

  • GC09P037111
  • GC09P037112
  • GC09P037113
  • GC09P037071

Summaries for ZCCHC7 Gene

GeneCards Summary for ZCCHC7 Gene

ZCCHC7 (Zinc Finger CCHC-Type Containing 7) is a Protein Coding gene. Among its related pathways are Deadenylation-dependent mRNA decay. GO annotations related to this gene include nucleic acid binding and poly(A) RNA binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCCHC7 Gene

Genomics for ZCCHC7 Gene

Regulatory Elements for ZCCHC7 Gene

Enhancers for ZCCHC7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZCCHC7 on UCSC Golden Path with GeneCards custom track

Promoters for ZCCHC7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZCCHC7 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZCCHC7 Gene

Chromosome:
9
Start:
37,120,169 bp from pter
End:
37,358,149 bp from pter
Size:
237,981 bases
Orientation:
Plus strand

Genomic View for ZCCHC7 Gene

Genes around ZCCHC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZCCHC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZCCHC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCCHC7 Gene

Proteins for ZCCHC7 Gene

  • Protein details for ZCCHC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3Z6-ZCHC7_HUMAN
    Recommended name:
    Zinc finger CCHC domain-containing protein 7
    Protein Accession:
    Q8N3Z6
    Secondary Accessions:
    • B2RCI4
    • D3DRQ0
    • Q5T0Q8
    • Q5T0Q9
    • Q5T0R0
    • Q8N2M1
    • Q8N4J2
    • Q8TBK8
    • Q9H648
    • Q9P0F0

    Protein attributes for ZCCHC7 Gene

    Size:
    543 amino acids
    Molecular mass:
    63052 Da
    Quaternary structure:
    • Component of a nucleolar TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of an helicase (SKIV2L2/MTR4), an oligadenylate polymerase (PAPD5 or PAPD7), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes.
    SequenceCaution:
    • Sequence=AAH36940.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15418.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAC11087.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG37581.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI12726.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZCCHC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZCCHC7 Gene

Proteomics data for ZCCHC7 Gene at MOPED

Post-translational modifications for ZCCHC7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZCCHC7 Gene

No data available for DME Specific Peptides for ZCCHC7 Gene

Domains & Families for ZCCHC7 Gene

Gene Families for ZCCHC7 Gene

Protein Domains for ZCCHC7 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8N3Z6

UniProtKB/Swiss-Prot:

ZCHC7_HUMAN :
  • Contains 4 CCHC-type zinc fingers.
Similarity:
  • Contains 4 CCHC-type zinc fingers.
genes like me logo Genes that share domains with ZCCHC7: view

Function for ZCCHC7 Gene

Gene Ontology (GO) - Molecular Function for ZCCHC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ZCCHC7: view

Phenotypes for ZCCHC7 Gene

genes like me logo Genes that share phenotypes with ZCCHC7: view

Animal Model Products

miRNA for ZCCHC7 Gene

miRTarBase miRNAs that target ZCCHC7

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZCCHC7 Gene

Localization for ZCCHC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZCCHC7 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZCCHC7 Gene COMPARTMENTS Subcellular localization image for ZCCHC7 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZCCHC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ZCCHC7: view

Pathways & Interactions for ZCCHC7 Gene

SuperPathways for ZCCHC7 Gene

Superpath Contained pathways
1 Deadenylation-dependent mRNA decay
genes like me logo Genes that share pathways with ZCCHC7: view

Pathways by source for ZCCHC7 Gene

1 KEGG pathway for ZCCHC7 Gene

Gene Ontology (GO) - Biological Process for ZCCHC7 Gene

None

No data available for SIGNOR curated interactions for ZCCHC7 Gene

Drugs & Compounds for ZCCHC7 Gene

No Compound Related Data Available

Transcripts for ZCCHC7 Gene

Unigene Clusters for ZCCHC7 Gene

Zinc finger, CCHC domain containing 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC7 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^
SP1: - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - -
SP5: - - - - - -
SP6:
SP7: - - - - - - - - - - -
SP8: - - - -
SP9: -
SP10: - - - - -
SP11: - -
SP12: - - -
SP13:
SP14:

ExUns: 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for ZCCHC7 Gene

GeneLoc Exon Structure for
ZCCHC7
ECgene alternative splicing isoforms for
ZCCHC7

Expression for ZCCHC7 Gene

mRNA expression in normal human tissues for ZCCHC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZCCHC7 Gene

This gene is overexpressed in Pancreatic juice (39.0), Fetal testis (16.2), and Testis (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZCCHC7 Gene



SOURCE GeneReport for Unigene cluster for ZCCHC7 Gene Hs.654700

genes like me logo Genes that share expression patterns with ZCCHC7: view

Protein tissue co-expression partners for ZCCHC7 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZCCHC7 Gene

Orthologs for ZCCHC7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZCCHC7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZCCHC7 35
  • 84.04 (n)
  • 73.57 (a)
ZCCHC7 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZCCHC7 35
  • 83.52 (n)
  • 73.99 (a)
ZCCHC7 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zcchc7 35
  • 78.59 (n)
  • 65.92 (a)
Zcchc7 16
Zcchc7 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zcchc7 35
  • 77.32 (n)
  • 65.42 (a)
oppossum
(Monodelphis domestica)
Mammalia ZCCHC7 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZCCHC7 36
  • 52 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZCCHC7 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101751525 35
  • 59.82 (n)
  • 50.53 (a)
-- 36
  • 40 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia ZCCHC7 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20212 35
zcchc7 35
  • 55.51 (n)
  • 43.79 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19467 35
zebrafish
(Danio rerio)
Actinopterygii zcchc7 35
  • 49.9 (n)
  • 41.04 (a)
zcchc7 36
  • 29 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9715 36
  • 6 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AIR1 36
  • 21 (a)
OneToMany
AIR2 36
  • 20 (a)
OneToMany
AIR2 38
Species with no ortholog for ZCCHC7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZCCHC7 Gene

ENSEMBL:
Gene Tree for ZCCHC7 (if available)
TreeFam:
Gene Tree for ZCCHC7 (if available)

Paralogs for ZCCHC7 Gene

Pseudogenes.org Pseudogenes for ZCCHC7 Gene

genes like me logo Genes that share paralogs with ZCCHC7: view

No data available for Paralogs for ZCCHC7 Gene

Variants for ZCCHC7 Gene

Sequence variations from dbSNP and Humsavar for ZCCHC7 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs35119826 - 37,126,685(-) AAAGA(C/T)CATGG intron-variant, reference, missense
rs1051465 - 37,357,252(+) GCAGA(A/G)AAAAA nc-transcript-variant, reference, missense
rs634942 -- 37,331,735(+) CCTGG(G/T)TAATT intron-variant
rs636285 -- 37,240,322(-) aatat(G/T)CTGAG intron-variant
rs641925 -- 37,311,989(+) AGAGT(C/T)ACTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZCCHC7 Gene

Variant ID Type Subtype PubMed ID
nsv893056 CNV Gain 21882294
nsv466390 CNV Loss 19166990
nsv529027 CNV Loss 19592680
nsv520965 CNV Loss 19592680
esv994123 CNV Deletion 20482838
esv271260 CNV Insertion 20981092
nsv6534 CNV Insertion 18451855
nsv831551 CNV Gain+Loss 17160897
nsv893057 CNV Gain 21882294
nsv6535 CNV Insertion 18451855

Variation tolerance for ZCCHC7 Gene

Residual Variation Intolerance Score: 95.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.92; 35.74% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZCCHC7 Gene

Disorders for ZCCHC7 Gene

Relevant External Links for ZCCHC7

Genetic Association Database (GAD)
ZCCHC7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZCCHC7

No disorders were found for ZCCHC7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZCCHC7 Gene

Publications for ZCCHC7 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 67
  2. New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein. (PMID: 25556234) Kipper S. … Bajorek M. (Mol. Cell Proteomics 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PMID: 23503679) Zhu J. … Elledge S.J. (Nat. Biotechnol. 2013) 3

Products for ZCCHC7 Gene

Sources for ZCCHC7 Gene

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