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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZCCHC7 Gene

protein-coding   GIFtS: 52
GCID: GC09P037120

zinc finger, CCHC domain containing 7

 Explore 1 disease affiliated with
ZCCHC7 via our new
 Human Malady Compendium 
Biological research products
for ZCCHC7
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger, CCHC Domain Containing 71 2
AIR11 2
FLJ226111
RP11-397D12.12
Zinc Finger CCHC Domain-Containing Protein 72

External Ids:    HGNC: 262091   Entrez Gene: 841862   Ensembl: ENSG000001479057   UniProtKB: Q8N3Z63   

Export aliases for ZCCHC7 gene to outside databases

Previous GC identifers: GC09P037111 GC09P037112 GC09P037113 GC09P037071


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZCCHC7 gene promoter:
         Max1   SREBP-1c   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   SREBP-1b   Evi-1   POU2F1   SREBP-1a   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZCCHC7 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZCCHC7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZCCHC7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.2   Ensembl cytogenetic band:  9p13.2   HGNC cytogenetic band: 9p13.1

ZCCHC7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZCCHC7 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P037120:  view genomic region     (about GC identifiers)

Start:
37,120,469 bp from pter      End:
37,358,146 bp from pter
Size:
237,678 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZCHC7_HUMAN, Q8N3Z6 (See protein sequence)
Recommended Name: Zinc finger CCHC domain-containing protein 7  
Size: 543 amino acids; 63052 Da
Caution: It is uncertain whether Met-1 or Met-2 is the initiator
Sequence caution: Sequence=AAH36940.1; Type=Erroneous initiation; Sequence=BAB15418.1; Type=Miscellaneous discrepancy;
Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAC11087.1; Type=Erroneous initiation;
Sequence=BAG37581.1; Type=Erroneous initiation; Sequence=CAI12726.1; Type=Erroneous initiation;
Secondary accessions: B2RCI4 D3DRQ0 Q5T0Q8 Q5T0Q9 Q5T0R0 Q8N2M1 Q8N4J2 Q8TBK8 Q9H648 Q9P0F0
Alternative splicing: 2 isoforms:  Q8N3Z6-1   Q8N3Z6-2   

Explore the universe of human proteins at neXtProt for ZCCHC7: NX_Q8N3Z6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N3Z6

  • ZCCHC7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_115602.2  
    ENSEMBL proteins: 
     ENSP00000337839   ENSP00000316365   ENSP00000443113  

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    Uscn Proteins for ZCCHC7

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--


    ZCCHC7 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZCCHC7 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001878 Znf_CCHC

    Graphical View of Domain Structure for InterPro Entry Q8N3Z6

    ProtoNet protein and cluster: Q8N3Z6

    1 Blocks protein family: IPB001878 C2HC-type zinc-finger signature

    UniProtKB/Swiss-Prot: ZCHC7_HUMAN, Q8N3Z6
    Similarity: Contains 4 CCHC-type zinc fingers


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    hsa-miR-1236
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    Inhib. RNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0008270zinc ion binding IEA--


    ZCCHC7 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ZCCHC7:
     Synthetic lethal with c-Myc af 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Deadenylation-dependent mRNA decay
    RNA degradation0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for ZCCHC7):
        RNA degradation


    ZCCHC7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZCCHC7

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/9 Interacting proteins for ZCCHC7 (Q8N3Z62, 3 ENSP000003378394) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNIP1Q8TAD82, 3MINT-62166 I2D: score=3 
    PAPD5Q8NDF83, ENSP000003969954I2D: score=1 STRING: ENSP00000396995
    PAPD7Q5XG873, ENSP000002308594I2D: score=1 STRING: ENSP00000230859
    SREBF2Q127723I2D: score=2 
    UBE2IP632793I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZCCHC7
    Search CenterWatch for drugs/clinical trials and news about ZCCHC7 / ZCHC7 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZCCHC7 gene: 
    NM_032226.2  

    Unigene Cluster for ZCCHC7:

    Zinc finger, CCHC domain containing 7
    Hs.654700  [show with all ESTs]
    Unigene Representative Sequence: AK126219
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336755(uc003zzq.3 uc011lqh.2 uc022bgu.1) ENST00000322831(uc003zzs.1)
    ENST00000461038(uc010mlt.3) ENST00000488607 ENST00000463625 ENST00000497924
    ENST00000481507 ENST00000496099 ENST00000470185 ENST00000534928

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate ZCCHC7:
    hsa-miR-1236
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    Inhib. RNA
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    Additional cDNA sequence: 

    AF161349.1 AK026264.1 AK074608.1 AK126219.1 AK303193.1 AK315128.1 BC005990.1 BC022434.1 
    BC034022.1 BC036940.1 

    24/28 DOTS entries (see all 28):

    DT.443289  DT.100810767  DT.100810774  DT.95160700  DT.91758828  DT.40263362  DT.439657  DT.121196594 
    DT.205246  DT.70102780  DT.91758811  DT.91758814  DT.100700157  DT.100810768  DT.410989  DT.91758824 
    DT.100768029  DT.100810770  DT.100810771  DT.121196628  DT.100810773  DT.120729579  DT.121196727  DT.121196737 

    24/272 AceView cDNA sequences (see all 272):

    BP344330 CR621518 CB122221 BX388557 BE675698 AL709194 BM469725 AK126219 
    CR611439 BE081597 BG530318 BQ231508 N28270 AW139513 AI418466 AA953501 
    BG613852 BX388667 AI701803 BQ422572 AA306945 H88669 BQ431321 N76847 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC7 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^
    SP1:                                -     -     -     -                       -     -     -     -     -     -     -                       -     -               
    SP2:                                -     -     -     -                       -     -     -     -     -     -     -                       -     -               
    SP3:                                            -     -                       -     -     -     -     -     -     -                       -     -               
    SP4:                                                                                                                                      -     -               
    SP5:                                      -     -                             -     -     -     -                                                               

    ExUns: 17
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for ZCCHC7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZCCHC7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAAAGCAAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    ZCCHC7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryPrimary FolliclePrimary OocyteFemale Gametocytes, Germ Cells
    EyeLensEye
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ZCCHC7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZCCHC7

    SOURCE GeneReport for Unigene cluster: Hs.654700
        SABiosciences Custom PCR Arrays for ZCCHC7
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCCHC7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZCCHC7 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zcchc71 , 5 zinc finger, CCHC domain containing 71, 5 78.71(n)1
    65.92(a)1
      4 (23.57 cM)5
    3198851  NM_138590.41  NP_613056.21 
     447558775 
    chicken
    (Gallus gallus)
    Aves ZCCHC71 zinc finger, CCHC domain containing 7 57.24(n)
    46.2(a)
      426807  XM_424418.3  XP_424418.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    32(a)
    22(a)
    many → 1
    many → 1
    GL343201.1(3578375-3590120)
    GL343201.1(3459942-3460619)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.194672 Xenopus laevis transcribed sequence with weak similarity more 76.52(n)    BU901366.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zcchc71 zinc finger, CCHC domain containing 7 49.97(n)
    41.04(a)
      317641  XM_001332506.4  XP_001332542.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG97156
    --
    6(a)
    1 ↔ 1
    3L(16838486-16845450)


    ENSEMBL Gene Tree for ZCCHC7 (if available)
    TreeFam Gene Tree for ZCCHC7 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZCCHC7 gene

    ZCCHC7 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ZCCHC7
    PGOHUM00000247812 PGOHUM00000248182


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3359 NCBI SNPs in ZCCHC7 are shown (see all 3359    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1849409981,2
    --37118490(+) TCTCTC/TTTGCT 1 -- us2k10--------
    rs1155909201,2
    F,--37118558(+) TTAAAG/ACGATT 1 -- us2k11Minor allele frequency- A:0.04WA 118
    rs1416313191,2
    --37118859(+) CACTTC/TGGGCT 1 -- us2k10--------
    rs123387321,2
    --37119267(+) gcctgA/Gccaac 1 -- us2k10--------
    rs1382917151,2
    --37119301(+) AAAATA/GCAAAA 1 -- us2k10--------
    rs123387701,2
    C,A,--37119368(+) AGGAGA/GATGGC 1 -- us2k12Minor allele frequency- G:0.33NA CSA 3
    rs120001911,2
    C,H--37119528(+) TACAAG/AAAGTG 1 -- us2k15Minor allele frequency- A:0.00NS EA NA 422
    rs78610991,2
    C,F,A,H,--37119544(+) GCTCAT/CGCCTG 1 -- us2k120Minor allele frequency- C:0.47NS EA NA WA CSA 2343
    rs120022631,2
    H--37119559(+) cccagG/Tgcttt 1 -- us2k10--------
    rs1503653701,2
    --37119799(+) TTGTAG/TTAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZCCHC7 (37120469 - 37358146 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ZCCHC7
         1 CNV: 52813

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZCCHC7
    DNA2.0 Custom Variant and Variant Library Synthesis for ZCCHC7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZCCHC7 for disorders           About GeneDecksing

    1 disease for ZCCHC7:    About MalaCards
    leukemia


    Export disorders for ZCCHC7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZCCHC7 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with ZCCHC7)
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    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    4. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    5. Air1 zinc knuckles 4 and 5 and a conserved IWRXY moti f are critical for the function and integrity of the Trf4/5-Air1/2-Mtr4 polyade nylation (TRAMP) RNA quality control complex. (PubMed id 21878619)1 Fasken M.B....Corbett A.H. (2011)
    6. Heterogeneous breakpoints in patients with acute lymp hoblastic leukemia and the dic(9;20)(p11-13;q11) show recurrent involvement of genes at 20q11.21. (PubMed id 19586940)1 An Q....Strefford J.C. (2009)
    7. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    10. Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84186 HGNC: 26209 AceView: ZCCHC7 Ensembl:ENSG00000147905 euGenes: HUgn84186
    ECgene: ZCCHC7 Kegg: 84186 H-InvDB: ZCCHC7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZCCHC7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZCCHC7 gene:
    Search GeneIP for patents involving ZCCHC7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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