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Aliases for ZCCHC7 Gene

Aliases for ZCCHC7 Gene

  • Zinc Finger, CCHC Domain Containing 7 2 3
  • TRAMP-Like Complex RNA-Binding Factor ZCCHC7 3 4
  • Zinc Finger CCHC Domain-Containing Protein 7 3
  • HSPC086 3
  • AIR1 3

External Ids for ZCCHC7 Gene

Previous GeneCards Identifiers for ZCCHC7 Gene

  • GC09P037111
  • GC09P037112
  • GC09P037113
  • GC09P037071

Summaries for ZCCHC7 Gene

GeneCards Summary for ZCCHC7 Gene

ZCCHC7 (Zinc Finger, CCHC Domain Containing 7) is a Protein Coding gene. Among its related pathways are Deadenylation-dependent mRNA decay. GO annotations related to this gene include nucleic acid binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCCHC7 Gene

Genomics for ZCCHC7 Gene

Genomic Location for ZCCHC7 Gene

37,120,164 bp from pter
37,358,149 bp from pter
237,986 bases
Plus strand

Genomic View for ZCCHC7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZCCHC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCCHC7 Gene

Proteins for ZCCHC7 Gene

  • Protein details for ZCCHC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger CCHC domain-containing protein 7
    Protein Accession:
    Secondary Accessions:
    • B2RCI4
    • D3DRQ0
    • Q5T0Q8
    • Q5T0Q9
    • Q5T0R0
    • Q8N2M1
    • Q8N4J2
    • Q8TBK8
    • Q9H648
    • Q9P0F0

    Protein attributes for ZCCHC7 Gene

    543 amino acids
    Molecular mass:
    63052 Da
    Quaternary structure:
    • Component of a nucleolar TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of an helicase (SKIV2L2/MTR4), an oligadenylate polymerase (PAPD5 or PAPD7), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes.
    • Sequence=AAH36940.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15418.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAC11087.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG37581.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI12726.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZCCHC7 Gene


neXtProt entry for ZCCHC7 Gene

Proteomics data for ZCCHC7 Gene at MOPED

Post-translational modifications for ZCCHC7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZCCHC7 Gene

No data available for DME Specific Peptides for ZCCHC7 Gene

Domains for ZCCHC7 Gene

Gene Families for ZCCHC7 Gene

  • ZCCHC :Zinc fingers, CCHC domain containing

Protein Domains for ZCCHC7 Gene


Graphical View of Domain Structure for InterPro Entry



  • Q8N3Z6
  • Contains 4 CCHC-type zinc fingers.
genes like me logo Genes that share domains with ZCCHC7: view

Function for ZCCHC7 Gene

Gene Ontology (GO) - Molecular Function for ZCCHC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ZCCHC7: view

Phenotypes for ZCCHC7 Gene

GenomeRNAi human phenotypes for ZCCHC7:
genes like me logo Genes that share phenotypes with ZCCHC7: view

miRNA for ZCCHC7 Gene

miRTarBase miRNAs that target ZCCHC7

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZCCHC7

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZCCHC7 Gene

Localization for ZCCHC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZCCHC7 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for ZCCHC7 Gene COMPARTMENTS Subcellular localization image for ZCCHC7 gene
Compartment Confidence
cytosol 4
nucleus 4
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZCCHC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ZCCHC7: view

Pathways for ZCCHC7 Gene

SuperPathways for ZCCHC7 Gene

Superpath Contained pathways
1 Deadenylation-dependent mRNA decay
genes like me logo Genes that share pathways with ZCCHC7: view

Pathways by source for ZCCHC7 Gene

1 KEGG pathway for ZCCHC7 Gene

Gene Ontology (GO) - Biological Process for ZCCHC7 Gene


Transcripts for ZCCHC7 Gene

Unigene Clusters for ZCCHC7 Gene

Zinc finger, CCHC domain containing 7:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZCCHC7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC7 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^
SP1: - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - -
SP5: - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - -
SP9: -
SP10: - - - - -
SP11: - -
SP12: - - -

ExUns: 17

Relevant External Links for ZCCHC7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZCCHC7 Gene

mRNA expression in normal human tissues for ZCCHC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ZCCHC7 Gene

This gene is overexpressed in Pancreatic juice (39.0), Fetal testis (16.2), and Testis (11.1).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ZCCHC7 Gene

SOURCE GeneReport for Unigene cluster for ZCCHC7 Gene Hs.654700

genes like me logo Genes that share expressions with ZCCHC7: view

Expression partners for ZCCHC7 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZCCHC7 Gene

Orthologs for ZCCHC7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZCCHC7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZCCHC7 35
  • 84.04 (n)
  • 73.57 (a)
  • 73 (a)
(Canis familiaris)
Mammalia ZCCHC7 35
  • 83.52 (n)
  • 73.99 (a)
  • 76 (a)
(Mus musculus)
Mammalia Zcchc7 35
  • 78.59 (n)
  • 65.92 (a)
Zcchc7 16
Zcchc7 36
  • 65 (a)
(Rattus norvegicus)
Mammalia Zcchc7 35
  • 77.32 (n)
  • 65.42 (a)
(Monodelphis domestica)
Mammalia ZCCHC7 36
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia ZCCHC7 36
  • 52 (a)
(Pan troglodytes)
Mammalia ZCCHC7 36
  • 99 (a)
(Gallus gallus)
Aves LOC101751525 35
  • 59.82 (n)
  • 50.53 (a)
-- 36
  • 40 (a)
-- 36
  • 43 (a)
(Anolis carolinensis)
Reptilia ZCCHC7 36
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20212 35
zcchc7 35
  • 55.51 (n)
  • 43.79 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19467 35
(Danio rerio)
Actinopterygii zcchc7 35
  • 49.9 (n)
  • 41.04 (a)
zcchc7 36
  • 29 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9715 36
  • 6 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AIR1 36
  • 21 (a)
AIR2 36
  • 20 (a)
AIR2 38
Species with no ortholog for ZCCHC7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZCCHC7 Gene

Gene Tree for ZCCHC7 (if available)
Gene Tree for ZCCHC7 (if available)

Paralogs for ZCCHC7 Gene Pseudogenes for ZCCHC7 Gene

genes like me logo Genes that share paralogs with ZCCHC7: view

No data available for Paralogs for ZCCHC7 Gene

Variants for ZCCHC7 Gene

Sequence variations from dbSNP and Humsavar for ZCCHC7 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs167429 -- 37,284,189(-) TTTCT(C/T)TCTCT intron-variant
rs182541 -- 37,350,702(+) CACTA(G/T)GCAGA intron-variant
rs182542 -- 37,350,247(-) ggagg(A/C)tgagg intron-variant
rs186298 -- 37,352,981(-) tattt(C/T)aataa intron-variant
rs186299 -- 37,356,406(+) GTACT(A/G)TGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZCCHC7 Gene

Variant ID Type Subtype PubMed ID
nsv893056 CNV Gain 21882294
nsv466390 CNV Loss 19166990
nsv529027 CNV Loss 19592680
nsv520965 CNV Loss 19592680
esv994123 CNV Deletion 20482838
esv271260 CNV Insertion 20981092
nsv6534 CNV Insertion 18451855
nsv831551 CNV Gain+Loss 17160897
nsv893057 CNV Gain 21882294
nsv6535 CNV Insertion 18451855

Relevant External Links for ZCCHC7 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZCCHC7 Gene

Disorders for ZCCHC7 Gene

Relevant External Links for ZCCHC7

Genetic Association Database (GAD)

No disorders were found for ZCCHC7 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ZCCHC7 Gene

Publications for ZCCHC7 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  4. Functional proteomics mapping of a human signaling pathway. (PMID: 15231748) Colland F. … Gauthier J.M. (Genome Res. 2004) 3
  5. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3

Products for ZCCHC7 Gene

Sources for ZCCHC7 Gene

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