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Aliases for ZCCHC7 Gene

Aliases for ZCCHC7 Gene

  • Zinc Finger CCHC-Type Containing 7 2 3 5
  • TRAMP-Like Complex RNA-Binding Factor ZCCHC7 3 4
  • Zinc Finger CCHC Domain-Containing Protein 7 3
  • Zinc Finger, CCHC Domain Containing 7 3
  • HSPC086 3
  • AIR1 3

External Ids for ZCCHC7 Gene

Previous GeneCards Identifiers for ZCCHC7 Gene

  • GC09P037111
  • GC09P037112
  • GC09P037113
  • GC09P037071

Summaries for ZCCHC7 Gene

GeneCards Summary for ZCCHC7 Gene

ZCCHC7 (Zinc Finger CCHC-Type Containing 7) is a Protein Coding gene. Among its related pathways are Deadenylation-dependent mRNA decay. GO annotations related to this gene include nucleic acid binding and poly(A) RNA binding.

Additional gene information for ZCCHC7 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCCHC7 Gene

Genomics for ZCCHC7 Gene

Regulatory Elements for ZCCHC7 Gene

Enhancers for ZCCHC7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H037119 1.4 ENCODE dbSUPER 33.2 +0.7 713 2 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZCCHC7 EXOSC3 DCAF10 TRMT10B ZBTB5 HMGB3P24 GC09P037160
GH09H037463 1.4 ENCODE dbSUPER 31.3 +346.1 346096 5 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 YY1 FOS SP3 DCAF10 EXOSC3 ZCCHC7 ZBTB5 RPL21P83 RNF38 TRMT10B GRHPR ALDH1B1 TMX2P1
GH09H037799 1.2 ENCODE 31 +681.0 680960 2 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC TRMT10B EXOSC3 ZCCHC7 POLR1E ZBTB5 LINC01400 SLC25A51 DCAF10
GH09H037485 1.3 ENCODE dbSUPER 25.6 +366.6 366632 3 HDGF FOXA2 PKNOX1 ATF1 ARNT ARID4B SIN3A DMAP1 YY1 GLIS2 RPL21P83 POLR1E ZCCHC7 EXOSC3 ZBTB5 FBXO10 ENSG00000234160 TRMT10B ENSG00000256966 TOMM5
GH09H037026 2 FANTOM5 Ensembl ENCODE dbSUPER 16.6 -88.0 -87976 12 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A YBX1 SLC30A9 ZNF143 ZNF207 PAX5 DCAF10 ZCCHC7 EXOSC3 POLR1E LOC105376032 ZBTB5 LOC105376031
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZCCHC7 on UCSC Golden Path with GeneCards custom track

Promoters for ZCCHC7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000234834 731 2201 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B

Genomic Location for ZCCHC7 Gene

Chromosome:
9
Start:
37,120,169 bp from pter
End:
37,358,149 bp from pter
Size:
237,981 bases
Orientation:
Plus strand

Genomic View for ZCCHC7 Gene

Genes around ZCCHC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZCCHC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZCCHC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCCHC7 Gene

Proteins for ZCCHC7 Gene

  • Protein details for ZCCHC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3Z6-ZCHC7_HUMAN
    Recommended name:
    Zinc finger CCHC domain-containing protein 7
    Protein Accession:
    Q8N3Z6
    Secondary Accessions:
    • B2RCI4
    • D3DRQ0
    • Q5T0Q8
    • Q5T0Q9
    • Q5T0R0
    • Q8N2M1
    • Q8N4J2
    • Q8TBK8
    • Q9H648
    • Q9P0F0

    Protein attributes for ZCCHC7 Gene

    Size:
    543 amino acids
    Molecular mass:
    63052 Da
    Quaternary structure:
    • Component of a nucleolar TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of a helicase (SKIV2L2/MTR4), an oligadenylate polymerase (PAPD5 or PAPD7), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes.
    SequenceCaution:
    • Sequence=AAH36940.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15418.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAC11087.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG37581.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI12726.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZCCHC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZCCHC7 Gene

Post-translational modifications for ZCCHC7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZCCHC7 Gene

Domains & Families for ZCCHC7 Gene

Gene Families for ZCCHC7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZCCHC7 Gene

Blocks:
InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZCCHC7: view

No data available for UniProtKB/Swiss-Prot for ZCCHC7 Gene

Function for ZCCHC7 Gene

Phenotypes From GWAS Catalog for ZCCHC7 Gene

Gene Ontology (GO) - Molecular Function for ZCCHC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZCCHC7: view
genes like me logo Genes that share phenotypes with ZCCHC7: view

Animal Model Products

CRISPR Products

miRNA for ZCCHC7 Gene

miRTarBase miRNAs that target ZCCHC7

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZCCHC7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZCCHC7 Gene

Localization for ZCCHC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZCCHC7 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZCCHC7 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoli (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZCCHC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA,IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZCCHC7: view

Pathways & Interactions for ZCCHC7 Gene

SuperPathways for ZCCHC7 Gene

SuperPathway Contained pathways
1 Deadenylation-dependent mRNA decay
genes like me logo Genes that share pathways with ZCCHC7: view

Pathways by source for ZCCHC7 Gene

1 KEGG pathway for ZCCHC7 Gene

Gene Ontology (GO) - Biological Process for ZCCHC7 Gene

None

No data available for SIGNOR curated interactions for ZCCHC7 Gene

Drugs & Compounds for ZCCHC7 Gene

No Compound Related Data Available

Transcripts for ZCCHC7 Gene

Unigene Clusters for ZCCHC7 Gene

Zinc finger, CCHC domain containing 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZCCHC7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC7 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^
SP1: - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - -
SP5: - - - - - -
SP6:
SP7: - - - - - - - - - - -
SP8: - - - -
SP9: -
SP10: - - - - -
SP11: - -
SP12: - - -
SP13:
SP14:

ExUns: 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for ZCCHC7 Gene

GeneLoc Exon Structure for
ZCCHC7
ECgene alternative splicing isoforms for
ZCCHC7

Expression for ZCCHC7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZCCHC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZCCHC7 Gene

This gene is overexpressed in Pancreatic juice (39.0), Fetal testis (16.2), and Testis (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZCCHC7 Gene



Protein tissue co-expression partners for ZCCHC7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZCCHC7 Gene:

ZCCHC7

SOURCE GeneReport for Unigene cluster for ZCCHC7 Gene:

Hs.654700

Evidence on tissue expression from TISSUES for ZCCHC7 Gene

  • Blood(4.3)
  • Nervous system(4.3)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with ZCCHC7: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZCCHC7 Gene

Orthologs for ZCCHC7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZCCHC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZCCHC7 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZCCHC7 33 34
  • 84.04 (n)
dog
(Canis familiaris)
Mammalia ZCCHC7 33 34
  • 83.52 (n)
mouse
(Mus musculus)
Mammalia Zcchc7 33 16 34
  • 78.59 (n)
rat
(Rattus norvegicus)
Mammalia Zcchc7 33
  • 77.32 (n)
oppossum
(Monodelphis domestica)
Mammalia ZCCHC7 34
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZCCHC7 34
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101751525 33
  • 59.82 (n)
-- 34
  • 43 (a)
OneToMany
-- 34
  • 40 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia ZCCHC7 34
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zcchc7 33
  • 55.51 (n)
Str.20212 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.19467 33
zebrafish
(Danio rerio)
Actinopterygii zcchc7 33 34
  • 49.9 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9715 34
  • 6 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AIR1 34
  • 21 (a)
OneToMany
AIR2 34 36
  • 20 (a)
OneToMany
Species where no ortholog for ZCCHC7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZCCHC7 Gene

ENSEMBL:
Gene Tree for ZCCHC7 (if available)
TreeFam:
Gene Tree for ZCCHC7 (if available)

Paralogs for ZCCHC7 Gene

Pseudogenes.org Pseudogenes for ZCCHC7 Gene

genes like me logo Genes that share paralogs with ZCCHC7: view

No data available for Paralogs for ZCCHC7 Gene

Variants for ZCCHC7 Gene

Sequence variations from dbSNP and Humsavar for ZCCHC7 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000003440 -- 37,123,436(+) CTTAA(A/G)GGCCA intron-variant
rs1000022929 -- 37,351,180(+) AAAGC(C/T)AGGAT intron-variant
rs1000029438 -- 37,148,641(+) TGTTA(C/T)AGGAT intron-variant
rs1000037542 -- 37,147,237(+) GGGAA(A/G)TTTAG intron-variant
rs1000038246 -- 37,306,923(+) GCTGG(C/G)ATTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZCCHC7 Gene

Variant ID Type Subtype PubMed ID
dgv3989n106 CNV deletion 24896259
esv3334090 CNV insertion 20981092
esv994123 CNV deletion 20482838
nsv1016398 CNV loss 25217958
nsv1075615 CNV deletion 25765185
nsv1125318 OTHER inversion 24896259
nsv466390 CNV loss 19166990
nsv520965 CNV loss 19592680
nsv529027 CNV loss 19592680
nsv614215 CNV loss 21841781
nsv6534 CNV insertion 18451855
nsv6535 CNV insertion 18451855
nsv831551 CNV gain+loss 17160897
nsv951703 CNV duplication 24416366
nsv982215 CNV duplication 23825009

Variation tolerance for ZCCHC7 Gene

Residual Variation Intolerance Score: 95.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.92; 35.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZCCHC7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZCCHC7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZCCHC7 Gene

Disorders for ZCCHC7 Gene

Relevant External Links for ZCCHC7

Genetic Association Database (GAD)
ZCCHC7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZCCHC7

No disorders were found for ZCCHC7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZCCHC7 Gene

Publications for ZCCHC7 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for ZCCHC7 Gene

Sources for ZCCHC7 Gene

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