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Aliases for ZCCHC6 Gene

Aliases for ZCCHC6 Gene

  • Zinc Finger, CCHC Domain Containing 6 2 3
  • Zinc Finger CCHC Domain-Containing Protein 6 3 4
  • TUTase 7 3 4
  • TUT7 3 4
  • PAP Associated Domain Containing 6 3
  • Terminal Uridylyltransferase 7 3
  • EC 4
  • KIAA1711 4
  • TUTase7 2
  • PAPD6 3
  • HS2 4

External Ids for ZCCHC6 Gene

Previous GeneCards Identifiers for ZCCHC6 Gene

  • GC09M084359
  • GC09M086132
  • GC09M088093
  • GC09M088902
  • GC09M058725

Summaries for ZCCHC6 Gene

GeneCards Summary for ZCCHC6 Gene

ZCCHC6 (Zinc Finger, CCHC Domain Containing 6) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA uridylyltransferase activity. An important paralog of this gene is TUT1.

UniProtKB/Swiss-Prot for ZCCHC6 Gene

  • Uridylyltransferase that mediates the terminal uridylation of some specific RNAs. Not involved in uridylation of precursor let-7 (pre-let-7) miRNA. Does not play a role in replication-dependent histone mRNA degradation.

Gene Wiki entry for ZCCHC6 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCCHC6 Gene

Genomics for ZCCHC6 Gene

Regulatory Elements for ZCCHC6 Gene

Genomic Location for ZCCHC6 Gene

86,287,733 bp from pter
86,354,487 bp from pter
66,755 bases
Minus strand

Genomic View for ZCCHC6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZCCHC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCCHC6 Gene

Proteins for ZCCHC6 Gene

  • Protein details for ZCCHC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Terminal uridylyltransferase 7
    Protein Accession:
    Secondary Accessions:
    • Q5H9T0
    • Q5VYS5
    • Q5VYS7
    • Q658Z9
    • Q659A2
    • Q6MZJ3
    • Q8N5F0
    • Q96N57
    • Q96NE8
    • Q9C0F2
    • Q9H8M6

    Protein attributes for ZCCHC6 Gene

    1495 amino acids
    Molecular mass:
    171229 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available
    • Sequence=BAB14584.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB71052.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZCCHC6 Gene

neXtProt entry for ZCCHC6 Gene

Proteomics data for ZCCHC6 Gene at MOPED

Post-translational modifications for ZCCHC6 Gene

  • Ubiquitination at Lys11 and Lys602
  • Modification sites at PhosphoSitePlus

Other Protein References for ZCCHC6 Gene

No data available for DME Specific Peptides for ZCCHC6 Gene

Domains for ZCCHC6 Gene

Gene Families for ZCCHC6 Gene

  • ZCCHC :Zinc fingers, CCHC domain containing

Protein Domains for ZCCHC6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q5VYS8
  • Contains 2 PAP-associated domains.
  • Belongs to the DNA polymerase type-B-like family.
  • Contains 3 CCHC-type zinc fingers.
genes like me logo Genes that share domains with ZCCHC6: view

Function for ZCCHC6 Gene

Molecular function for ZCCHC6 Gene

UniProtKB/Swiss-Prot CatalyticActivity: UTP + RNA(n) = diphosphate + RNA(n+1).
UniProtKB/Swiss-Prot Function: Uridylyltransferase that mediates the terminal uridylation of some specific RNAs. Not involved in uridylation of precursor let-7 (pre-let-7) miRNA. Does not play a role in replication-dependent histone mRNA degradation.

Enzyme Numbers (IUBMB) for ZCCHC6 Gene

Gene Ontology (GO) - Molecular Function for ZCCHC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0050265 RNA uridylyltransferase activity IDA 17353264
genes like me logo Genes that share ontologies with ZCCHC6: view

miRNA for ZCCHC6 Gene

miRTarBase miRNAs that target ZCCHC6

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZCCHC6 Gene

Localization for ZCCHC6 Gene

Subcellular locations from

Jensen Localization Image for ZCCHC6 Gene COMPARTMENTS Subcellular localization image for ZCCHC6 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZCCHC6 Gene

Pathways for ZCCHC6 Gene

SuperPathways for ZCCHC6 Gene

No Data Available

Interacting Proteins for ZCCHC6 Gene

Gene Ontology (GO) - Biological Process for ZCCHC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031123 RNA 3-end processing IDA 17353264
GO:0071044 NOT histone mRNA catabolic process IMP 18172165
genes like me logo Genes that share ontologies with ZCCHC6: view

No data available for Pathways by source for ZCCHC6 Gene

Transcripts for ZCCHC6 Gene

Unigene Clusters for ZCCHC6 Gene

Zinc finger, CCHC domain containing 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^
SP2: - - -
SP5: -

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29
SP1: - -
SP3: - - -

Relevant External Links for ZCCHC6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZCCHC6 Gene

mRNA expression in normal human tissues for ZCCHC6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZCCHC6 Gene

This gene is overexpressed in Whole Blood (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZCCHC6 Gene

SOURCE GeneReport for Unigene cluster for ZCCHC6 Gene Hs.597057

genes like me logo Genes that share expressions with ZCCHC6: view

No data available for mRNA Expression by UniProt/SwissProt for ZCCHC6 Gene

Orthologs for ZCCHC6 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZCCHC6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZCCHC6 35
  • 99.82 (n)
  • 99.73 (a)
  • 100 (a)
(Bos Taurus)
Mammalia ZCCHC6 35
  • 89.6 (n)
  • 87.12 (a)
  • 87 (a)
(Canis familiaris)
Mammalia ZCCHC6 35
  • 89.99 (n)
  • 88.1 (a)
  • 88 (a)
(Mus musculus)
Mammalia Zcchc6 35
  • 82.53 (n)
  • 81.46 (a)
Zcchc6 16
Zcchc6 36
  • 81 (a)
(Monodelphis domestica)
Mammalia ZCCHC6 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia ZCCHC6 36
  • 79 (a)
(Rattus norvegicus)
Mammalia Zcchc6 35
  • 82 (n)
  • 80.94 (a)
(Gallus gallus)
Aves ZCCHC6 35
  • 71.25 (n)
  • 66.62 (a)
  • 63 (a)
(Anolis carolinensis)
Reptilia ZCCHC6 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.756 35
zcchc6 35
  • 63.19 (n)
  • 59.32 (a)
(Danio rerio)
Actinopterygii LOC562358 35
  • 55.18 (n)
  • 52.36 (a)
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta mkg-p 36
  • 14 (a)
(Caenorhabditis elegans)
Secernentea cid-1 36
  • 20 (a)
K05C4.4 36
  • 15 (a)
pup-2 36
  • 25 (a)
Y34F4.3 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5065 36
  • 42 (a)
Species with no ortholog for ZCCHC6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZCCHC6 Gene

Gene Tree for ZCCHC6 (if available)
Gene Tree for ZCCHC6 (if available)

Paralogs for ZCCHC6 Gene

Paralogs for ZCCHC6 Gene

Selected SIMAP similar genes for ZCCHC6 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZCCHC6: view

Variants for ZCCHC6 Gene

Sequence variations from dbSNP and Humsavar for ZCCHC6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs12099 -- 86,299,088(+) GGCCC(A/G)CACTG intron-variant
rs700758 -- 86,316,789(+) CATTA(A/G)TAAAC intron-variant, downstream-variant-500B
rs700759 -- 86,318,757(+) TACAG(A/G)GTGAA intron-variant
rs700760 -- 86,319,709(+) AAGCC(G/T)GTTGA intron-variant
rs700761 -- 86,319,932(+) GGCTC(A/C)AGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZCCHC6 Gene

Variant ID Type Subtype PubMed ID
nsv893536 CNV Gain 21882294
nsv893538 CNV Gain 21882294
nsv518696 CNV Loss 19592680
nsv893539 CNV Loss 21882294

Relevant External Links for ZCCHC6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZCCHC6 Gene

Disorders for ZCCHC6 Gene

Relevant External Links for ZCCHC6

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with ZCCHC6: view

No data available for UniProtKB/Swiss-Prot for ZCCHC6 Gene

Publications for ZCCHC6 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Efficient RNA polyuridylation by noncanonical poly(A) polymerases. (PMID: 17353264) Rissland O.S. … Norbury C.J. (Mol. Cell. Biol. 2007) 3 4

Products for ZCCHC6 Gene

Sources for ZCCHC6 Gene

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