Aliases for ZCCHC6 Gene
External Ids for ZCCHC6 Gene
Previous GeneCards Identifiers for ZCCHC6 Gene
GeneCards Summary for ZCCHC6 Gene
ZCCHC6 (Zinc Finger CCHC-Type Containing 6) is a Protein Coding gene. Diseases associated with ZCCHC6 include Perlman Syndrome. GO annotations related to this gene include nucleic acid binding and RNA uridylyltransferase activity. An important paralog of this gene is ZCCHC11.
UniProtKB/Swiss-Prot for ZCCHC6 Gene
Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult.