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Aliases for ZCCHC6 Gene

Aliases for ZCCHC6 Gene

  • Zinc Finger CCHC-Type Containing 6 2 3 5
  • Zinc Finger CCHC Domain-Containing Protein 6 3 4
  • TUTase 7 3 4
  • TUT7 3 4
  • Zinc Finger, CCHC Domain Containing 6 3
  • PAP Associated Domain Containing 6 3
  • Terminal Uridylyltransferase 7 3
  • EC 2.7.7.52 4
  • KIAA1711 4
  • TUTase7 2
  • PAPD6 3
  • HS2 4

External Ids for ZCCHC6 Gene

Previous GeneCards Identifiers for ZCCHC6 Gene

  • GC09M084359
  • GC09M086132
  • GC09M088093
  • GC09M088902
  • GC09M058725

Summaries for ZCCHC6 Gene

GeneCards Summary for ZCCHC6 Gene

ZCCHC6 (Zinc Finger CCHC-Type Containing 6) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA uridylyltransferase activity. An important paralog of this gene is ZCCHC11.

UniProtKB/Swiss-Prot for ZCCHC6 Gene

  • Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult.

Gene Wiki entry for ZCCHC6 Gene

Additional gene information for ZCCHC6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCCHC6 Gene

Genomics for ZCCHC6 Gene

Regulatory Elements for ZCCHC6 Gene

Enhancers for ZCCHC6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H086405 1.6 FANTOM5 Ensembl ENCODE 13.5 -52.3 -52312 3 FOXA2 MLX ARID4B FEZF1 DMAP1 YY1 SLC30A9 FOS SP5 MXD4 ZCCHC6 GOLM1 C9orf153 GC09P086413 RPS6P13
GH09H086337 1.1 Ensembl ENCODE 7.6 +15.4 15429 4 PKNOX1 TBL1XR1 INSM2 BACH1 BMI1 CHD7 BATF EED ZNF143 ATF7 ZCCHC6 C9orf153 GC09M086340 ISCA1
GH09H086349 1.1 ENCODE 6.9 +1.4 1420 6 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 C9orf153 RN7SKP264 LOC389765 ZCCHC6 GC09M086340
GH09H086280 1.1 ENCODE 6.1 +72.1 72142 2 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF207 C9orf153 RN7SKP264 ENSG00000270688 LOC102724080 LOC100287212 ENSG00000232211 ENSG00000229454 LOC494127 GAS1RR GAS1
GH09H086284 0.7 ENCODE 6.1 +69.3 69297 1 SMARCE1 LEF1 PKNOX1 TBL1XR1 MTA2 TAL1 REST DPF2 ZNF592 TCF12 ZCCHC6 C9orf153 ISCA1 GC09M086340
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZCCHC6 on UCSC Golden Path with GeneCards custom track

Promoters for ZCCHC6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000237049 201 2201 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for ZCCHC6 Gene

Chromosome:
9
Start:
86,287,733 bp from pter
End:
86,354,501 bp from pter
Size:
66,769 bases
Orientation:
Minus strand

Genomic View for ZCCHC6 Gene

Genes around ZCCHC6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZCCHC6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZCCHC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCCHC6 Gene

Proteins for ZCCHC6 Gene

  • Protein details for ZCCHC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VYS8-TUT7_HUMAN
    Recommended name:
    Terminal uridylyltransferase 7
    Protein Accession:
    Q5VYS8
    Secondary Accessions:
    • Q5H9T0
    • Q5VYS5
    • Q5VYS7
    • Q658Z9
    • Q659A2
    • Q6MZJ3
    • Q8N5F0
    • Q96N57
    • Q96NE8
    • Q9C0F2
    • Q9H8M6

    Protein attributes for ZCCHC6 Gene

    Size:
    1495 amino acids
    Molecular mass:
    171229 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14584.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB71052.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZCCHC6 Gene

neXtProt entry for ZCCHC6 Gene

Post-translational modifications for ZCCHC6 Gene

  • Ubiquitination at isoforms=2, 3, 4, 5, 611 and Lys602
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZCCHC6 Gene

Domains & Families for ZCCHC6 Gene

Gene Families for ZCCHC6 Gene

Graphical View of Domain Structure for InterPro Entry

Q5VYS8

UniProtKB/Swiss-Prot:

TUT7_HUMAN :
  • Belongs to the DNA polymerase type-B-like family.
Family:
  • Belongs to the DNA polymerase type-B-like family.
genes like me logo Genes that share domains with ZCCHC6: view

Function for ZCCHC6 Gene

Molecular function for ZCCHC6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UTP + RNA(n) = diphosphate + RNA(n+1).
UniProtKB/Swiss-Prot Function:
Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult.

Enzyme Numbers (IUBMB) for ZCCHC6 Gene

Phenotypes From GWAS Catalog for ZCCHC6 Gene

Gene Ontology (GO) - Molecular Function for ZCCHC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA 22658674
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0016779 nucleotidyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZCCHC6: view

Phenotypes for ZCCHC6 Gene

GenomeRNAi human phenotypes for ZCCHC6:
genes like me logo Genes that share phenotypes with ZCCHC6: view

Animal Model Products

CRISPR Products

miRNA for ZCCHC6 Gene

miRTarBase miRNAs that target ZCCHC6

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZCCHC6 Gene

Localization for ZCCHC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZCCHC6 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZCCHC6 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZCCHC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ZCCHC6: view

Pathways & Interactions for ZCCHC6 Gene

SuperPathways for ZCCHC6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZCCHC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0031123 RNA 3-end processing IDA 17353264
GO:0071044 NOT histone mRNA catabolic process IMP 18172165
genes like me logo Genes that share ontologies with ZCCHC6: view

No data available for Pathways by source and SIGNOR curated interactions for ZCCHC6 Gene

Drugs & Compounds for ZCCHC6 Gene

(1) Drugs for ZCCHC6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uridine triphosphate Experimental Pharma 0

(1) Additional Compounds for ZCCHC6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with ZCCHC6: view

Transcripts for ZCCHC6 Gene

Unigene Clusters for ZCCHC6 Gene

Zinc finger, CCHC domain containing 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^
SP1:
SP2: - - -
SP3:
SP4:
SP5: -
SP6:
SP7:

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29
SP1: - -
SP2:
SP3: - - -
SP4:
SP5:
SP6:
SP7:

Relevant External Links for ZCCHC6 Gene

GeneLoc Exon Structure for
ZCCHC6
ECgene alternative splicing isoforms for
ZCCHC6

Expression for ZCCHC6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZCCHC6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZCCHC6 Gene

This gene is overexpressed in Whole Blood (x5.3).

Protein differential expression in normal tissues from HIPED for ZCCHC6 Gene

This gene is overexpressed in Pancreas (29.4), Peripheral blood mononuclear cells (7.8), and Breast (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZCCHC6 Gene



Protein tissue co-expression partners for ZCCHC6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZCCHC6 Gene:

ZCCHC6

SOURCE GeneReport for Unigene cluster for ZCCHC6 Gene:

Hs.597057

Evidence on tissue expression from TISSUES for ZCCHC6 Gene

  • Nervous system(4.7)
  • Liver(4.3)
  • Muscle(4.3)
genes like me logo Genes that share expression patterns with ZCCHC6: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZCCHC6 Gene

Orthologs for ZCCHC6 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZCCHC6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZCCHC6 33 34
  • 99.82 (n)
dog
(Canis familiaris)
Mammalia ZCCHC6 33 34
  • 89.99 (n)
cow
(Bos Taurus)
Mammalia ZCCHC6 33 34
  • 89.6 (n)
mouse
(Mus musculus)
Mammalia Zcchc6 33 16 34
  • 82.53 (n)
rat
(Rattus norvegicus)
Mammalia Zcchc6 33
  • 82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZCCHC6 34
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZCCHC6 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZCCHC6 33 34
  • 71.25 (n)
lizard
(Anolis carolinensis)
Reptilia ZCCHC6 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zcchc6 33
  • 63.19 (n)
Str.756 33
zebrafish
(Danio rerio)
Actinopterygii LOC562358 33
  • 55.18 (n)
ZCCHC6 34
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mkg-p 34
  • 14 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea pup-2 34
  • 25 (a)
ManyToMany
Y34F4.3 34
  • 20 (a)
ManyToMany
cid-1 34
  • 20 (a)
ManyToMany
K05C4.4 34
  • 15 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5065 34
  • 42 (a)
OneToMany
Species where no ortholog for ZCCHC6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZCCHC6 Gene

ENSEMBL:
Gene Tree for ZCCHC6 (if available)
TreeFam:
Gene Tree for ZCCHC6 (if available)

Paralogs for ZCCHC6 Gene

Paralogs for ZCCHC6 Gene

(1) SIMAP similar genes for ZCCHC6 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZCCHC6: view

Variants for ZCCHC6 Gene

Sequence variations from dbSNP and Humsavar for ZCCHC6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000064801 -- 86,336,013(+) AGGAG(A/T)ATCTC intron-variant
rs1000075016 -- 86,342,883(+) AAAGA(G/T)CTATA intron-variant
rs1000076465 -- 86,351,099(+) ACTGC(A/C)CCTCC intron-variant
rs1000086092 -- 86,295,550(+) TATTA(A/G)TACAC intron-variant, utr-variant-3-prime
rs1000117655 -- 86,352,708(+) GACGT(A/G)GTTTC nc-transcript-variant, reference, synonymous-codon, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZCCHC6 Gene

Variant ID Type Subtype PubMed ID
nsv518696 CNV loss 19592680

Variation tolerance for ZCCHC6 Gene

Residual Variation Intolerance Score: 15.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.94; 59.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZCCHC6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZCCHC6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZCCHC6 Gene

Disorders for ZCCHC6 Gene

Relevant External Links for ZCCHC6

Genetic Association Database (GAD)
ZCCHC6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZCCHC6

No disorders were found for ZCCHC6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZCCHC6 Gene

Publications for ZCCHC6 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 60
  2. Uridylation by TUT4 and TUT7 marks mRNA for degradation. (PMID: 25480299) Lim J … Kim VN (Cell 2014) 3 4 60
  3. Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7). (PMID: 22898984) Thornton JE … Gregory RI (RNA (New York, N.Y.) 2012) 3 4 60
  4. Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'. (PMID: 18172165) Mullen TE … Marzluff WF (Genes & development 2008) 3 4 60
  5. Efficient RNA polyuridylation by noncanonical poly(A) polymerases. (PMID: 17353264) Rissland OS … Norbury CJ (Molecular and cellular biology 2007) 3 4 60

Products for ZCCHC6 Gene

Sources for ZCCHC6 Gene

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