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Aliases for ZCCHC6 Gene

Aliases for ZCCHC6 Gene

  • Zinc Finger CCHC-Type Containing 6 2 3
  • Zinc Finger CCHC Domain-Containing Protein 6 3 4
  • Zinc Finger, CCHC Domain Containing 6 3 5
  • TUTase 7 3 4
  • TUT7 3 4
  • PAP Associated Domain Containing 6 3
  • EC 2.7.7.52 4
  • KIAA1711 4
  • TUTase7 2
  • PAPD6 3
  • HS2 4

External Ids for ZCCHC6 Gene

Previous GeneCards Identifiers for ZCCHC6 Gene

  • GC09M084359
  • GC09M086132
  • GC09M088093
  • GC09M088902
  • GC09M058725

Summaries for ZCCHC6 Gene

GeneCards Summary for ZCCHC6 Gene

ZCCHC6 (Zinc Finger CCHC-Type Containing 6) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA uridylyltransferase activity. An important paralog of this gene is TUT1.

UniProtKB/Swiss-Prot for ZCCHC6 Gene

  • Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult.

Gene Wiki entry for ZCCHC6 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCCHC6 Gene

Genomics for ZCCHC6 Gene

Regulatory Elements for ZCCHC6 Gene

Promoters for ZCCHC6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZCCHC6 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZCCHC6 Gene

Chromosome:
9
Start:
86,287,733 bp from pter
End:
86,354,501 bp from pter
Size:
66,769 bases
Orientation:
Minus strand

Genomic View for ZCCHC6 Gene

Genes around ZCCHC6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZCCHC6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZCCHC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCCHC6 Gene

Proteins for ZCCHC6 Gene

  • Protein details for ZCCHC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VYS8-TUT7_HUMAN
    Recommended name:
    Terminal uridylyltransferase 7
    Protein Accession:
    Q5VYS8
    Secondary Accessions:
    • Q5H9T0
    • Q5VYS5
    • Q5VYS7
    • Q658Z9
    • Q659A2
    • Q6MZJ3
    • Q8N5F0
    • Q96N57
    • Q96NE8
    • Q9C0F2
    • Q9H8M6

    Protein attributes for ZCCHC6 Gene

    Size:
    1495 amino acids
    Molecular mass:
    171229 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14584.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB71052.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZCCHC6 Gene

neXtProt entry for ZCCHC6 Gene

Proteomics data for ZCCHC6 Gene at MOPED

Post-translational modifications for ZCCHC6 Gene

  • Ubiquitination at Lys 11 and Lys 602
  • Modification sites at PhosphoSitePlus

Other Protein References for ZCCHC6 Gene

No data available for DME Specific Peptides for ZCCHC6 Gene

Domains & Families for ZCCHC6 Gene

Gene Families for ZCCHC6 Gene

Graphical View of Domain Structure for InterPro Entry

Q5VYS8

UniProtKB/Swiss-Prot:

TUT7_HUMAN :
  • Contains 2 PAP-associated domains.
  • Belongs to the DNA polymerase type-B-like family.
  • Contains 3 CCHC-type zinc fingers.
Domain:
  • Contains 2 PAP-associated domains.
Family:
  • Belongs to the DNA polymerase type-B-like family.
Similarity:
  • Contains 3 CCHC-type zinc fingers.
genes like me logo Genes that share domains with ZCCHC6: view

Function for ZCCHC6 Gene

Molecular function for ZCCHC6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UTP + RNA(n) = diphosphate + RNA(n+1).
UniProtKB/Swiss-Prot Function:
Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult.

Enzyme Numbers (IUBMB) for ZCCHC6 Gene

Gene Ontology (GO) - Molecular Function for ZCCHC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ZCCHC6: view

Phenotypes for ZCCHC6 Gene

GenomeRNAi human phenotypes for ZCCHC6:
genes like me logo Genes that share phenotypes with ZCCHC6: view

Animal Model Products

miRNA for ZCCHC6 Gene

miRTarBase miRNAs that target ZCCHC6

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZCCHC6 Gene

Localization for ZCCHC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZCCHC6 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZCCHC6 Gene COMPARTMENTS Subcellular localization image for ZCCHC6 gene
Compartment Confidence
nucleus 4
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for ZCCHC6 Gene

Pathways & Interactions for ZCCHC6 Gene

SuperPathways for ZCCHC6 Gene

No Data Available

Interacting Proteins for ZCCHC6 Gene

Gene Ontology (GO) - Biological Process for ZCCHC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with ZCCHC6: view

No data available for Pathways by source and SIGNOR curated interactions for ZCCHC6 Gene

Drugs & Compounds for ZCCHC6 Gene

(2) Drugs for ZCCHC6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Diphosphate Experimental Pharma 0
Uridine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ZCCHC6: view

Transcripts for ZCCHC6 Gene

Unigene Clusters for ZCCHC6 Gene

Zinc finger, CCHC domain containing 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^
SP1:
SP2: - - -
SP3:
SP4:
SP5: -
SP6:
SP7:

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29
SP1: - -
SP2:
SP3: - - -
SP4:
SP5:
SP6:
SP7:

Relevant External Links for ZCCHC6 Gene

GeneLoc Exon Structure for
ZCCHC6
ECgene alternative splicing isoforms for
ZCCHC6

Expression for ZCCHC6 Gene

mRNA expression in normal human tissues for ZCCHC6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZCCHC6 Gene

This gene is overexpressed in Whole Blood (x5.3).

Protein differential expression in normal tissues from HIPED for ZCCHC6 Gene

This gene is overexpressed in Pancreas (29.4), Peripheral blood mononuclear cells (7.8), and Breast (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZCCHC6 Gene



SOURCE GeneReport for Unigene cluster for ZCCHC6 Gene Hs.597057

genes like me logo Genes that share expression patterns with ZCCHC6: view

Protein tissue co-expression partners for ZCCHC6 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ZCCHC6 Gene

Orthologs for ZCCHC6 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZCCHC6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZCCHC6 35
  • 89.6 (n)
  • 87.12 (a)
ZCCHC6 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZCCHC6 35
  • 89.99 (n)
  • 88.1 (a)
ZCCHC6 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zcchc6 35
  • 82.53 (n)
  • 81.46 (a)
Zcchc6 16
Zcchc6 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZCCHC6 35
  • 99.82 (n)
  • 99.73 (a)
ZCCHC6 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zcchc6 35
  • 82 (n)
  • 80.94 (a)
oppossum
(Monodelphis domestica)
Mammalia ZCCHC6 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZCCHC6 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZCCHC6 35
  • 71.25 (n)
  • 66.62 (a)
ZCCHC6 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZCCHC6 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.756 35
zcchc6 35
  • 63.19 (n)
  • 59.32 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC562358 35
  • 55.18 (n)
  • 52.36 (a)
ZCCHC6 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mkg-p 36
  • 14 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea cid-1 36
  • 20 (a)
ManyToMany
K05C4.4 36
  • 15 (a)
ManyToMany
pup-2 36
  • 25 (a)
ManyToMany
Y34F4.3 36
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5065 36
  • 42 (a)
OneToMany
Species with no ortholog for ZCCHC6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZCCHC6 Gene

ENSEMBL:
Gene Tree for ZCCHC6 (if available)
TreeFam:
Gene Tree for ZCCHC6 (if available)

Paralogs for ZCCHC6 Gene

Paralogs for ZCCHC6 Gene

(1) SIMAP similar genes for ZCCHC6 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZCCHC6: view

Variants for ZCCHC6 Gene

Sequence variations from dbSNP and Humsavar for ZCCHC6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs2378695 - 86,353,081(+) CTTTA(A/C/G)CATGG reference, missense
rs12099 -- 86,299,088(+) GGCCC(A/G)CACTG intron-variant
rs700758 -- 86,316,789(+) CATTA(A/G)TAAAC intron-variant
rs700759 -- 86,318,757(+) TACAG(A/G)GTGAA intron-variant
rs700760 -- 86,319,709(+) AAGCC(G/T)GTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZCCHC6 Gene

Variant ID Type Subtype PubMed ID
nsv893536 CNV Gain 21882294
nsv893538 CNV Gain 21882294
nsv518696 CNV Loss 19592680
nsv893539 CNV Loss 21882294

Variation tolerance for ZCCHC6 Gene

Residual Variation Intolerance Score: 15.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.94; 59.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZCCHC6 Gene

HapMap Linkage Disequilibrium report
ZCCHC6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZCCHC6 Gene

Disorders for ZCCHC6 Gene

Relevant External Links for ZCCHC6

Genetic Association Database (GAD)
ZCCHC6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZCCHC6

No disorders were found for ZCCHC6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZCCHC6 Gene

Publications for ZCCHC6 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. TUT7 controls the fate of precursor microRNAs by using three different uridylation mechanisms. (PMID: 25979828) Kim B. … Kim V.N. (EMBO J. 2015) 3
  3. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3
  4. Uridylation by TUT4 and TUT7 marks mRNA for degradation. (PMID: 25480299) Lim J. … Kim V.N. (Cell 2014) 3
  5. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PMID: 22586326) Tsai Y.C. … Cristea I.M. (Mol. Cell. Proteomics 2012) 3

Products for ZCCHC6 Gene

Sources for ZCCHC6 Gene

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