ZCCHC4 Gene
protein-coding GIFtS: 39
GCID: GC04P025314
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|
zinc finger, CCHC domain containing 4
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Aliases
for ZCCHC4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger, CCHC Domain Containing 41 2 | | HSPC0521 2 | | FLJ230241 | | DHHC Domain-Containing Zinc Finger Protein2 | | Zinc Finger CCHC Domain-Containing Protein 42 |
Export aliases for ZCCHC4 gene to outside databasesPrevious GC identifers: GC04U900073 GC04P025065 GC04P024990 GC04P024923 GC04P024654 |
Summaries
for ZCCHC4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZCHC4_HUMAN, Q9H5U6Function: May be a methyltransferase
|
Genomic Views
for ZCCHC4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_006316.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZCCHC4 gene promoter:
c-Fos AP-1 RREB-1 JunB Fra-1 FosB CUTL1 GATA-1 JunD c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZCCHC4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZCCHC4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p15.2 Ensembl cytogenetic band: 4p15.2 HGNC cytogenetic band: 4p15.31ZCCHC4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P025314: view genomic region
(about GC identifiers)
Start:
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25,314,396 bp from pter |
End:
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25,372,005 bp from pter |
Size:
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57,610 bases |
Orientation:
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plus strand |
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Proteins
for ZCCHC4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZCHC4_HUMAN, Q9H5U6 (See
protein sequence)Recommended Name: Zinc finger CCHC domain-containing protein 4 Size: 513 amino acids; 59010 Da
Sequence caution: Sequence=AAH16914.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAB15524.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B2RXF6 B4DRD8 B7ZW20 Q5IW78 Q96AN7Alternative splicing: 3 isoforms: Q9H5U6-1 Q9H5U6-2 Q9H5U6-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZCCHC4: NX_Q9H5U6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H5U6
ZCCHC4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079212.2
ENSEMBL proteins: ENSP00000303468 ENSP00000422115 ENSP00000422269
Human Recombinant Protein Products:
ZCCHC4 Antibody Products:
Assay Products for ZCCHC4: |
Protein
Domains /
Families
for ZCCHC4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZCCHC4 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H5U6ProtoNet protein and cluster: Q9H5U6 4 Blocks protein families: IPB001594 Zn-finger IPB001878 C2HC-type zinc-finger signature IPB002052 N-6 Adenine-specific DNA methylase IPB010666 GRF zinc finger
UniProtKB/Swiss-Prot: ZCHC4_HUMAN, Q9H5U6Similarity: Contains 1 CCHC-type zinc fingerSimilarity: Contains 1 DHHC-type zinc finger |
Function
for ZCCHC4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZCHC4_HUMAN, Q9H5U6Function: May be a methyltransferase
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZCCHC4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZCCHC4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for ZCCHC4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZCCHC4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCCHC4 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
IEA | -- | | GO:0008168 | methyltransferase activity |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
ZCCHC4 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZCCHC4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZCCHC4
|
Drugs & Compounds
for ZCCHC4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZCCHC4
Search CenterWatch for drugs/clinical trials and news about ZCCHC4 / ZCHC4
|
Transcripts
for ZCCHC4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZCCHC4 gene: NM_024936.2 Unigene Cluster for ZCCHC4: Zinc finger, CCHC domain containing 4 Hs.278945 [show with all ESTs]Unigene Representative Sequence: NM_0249365 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000505451(uc003grm.1) ENST00000302874(uc003grl.4) ENST00000507760
ENST00000505412 ENST00000508058
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZCCHC4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZCCHC4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZCCHC4 (NM_024936) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZCCHC4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZCCHC4 |
Additional cDNA sequence: AF161537.1 AK026677.1 AK299211.1 AK309675.1 AY629351.1 BC016914.1 BC157834.1 BC171821.1 7 DOTS entries: DT.70103592 DT.40113534 DT.100777767 DT.75126464 DT.100777766 DT.100647803 DT.91811566 24/47 AceView cDNA sequences (see all 47): AA746804 CR619058 AL515869 R86073 CR610354 AW089587 AK026677 AI092149 AI698232 BC016914 AW613723 BX099350 N39296 AL515868 AA460866 CB269174 BX375764 BG719159 BQ228967 BU601731 BX348886 AI886021 BG779772 BG687032
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC4 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | |
ECgene alternative splicing isoforms for ZCCHC4
|
Expression
for ZCCHC4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZCCHC4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCCACCTCA
About this image
See ZCCHC4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZCCHC4
SOURCE GeneReport for Unigene cluster: Hs.278945
SABiosciences Custom PCR Arrays for ZCCHC4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZCCHC4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZCCHC4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZCCHC4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZCCHC4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCCHC4 |
Orthologs
for ZCCHC4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZCCHC4 gene from 6/17 species (see all 17) About this table
ENSEMBL Gene Tree for ZCCHC4 (if available)
TreeFam Gene Tree for ZCCHC4 (if available) |
Paralogs
for ZCCHC4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ZCCHC4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZCCHC4 |
|
Disorders
/ Diseases
for ZCCHC4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZCCHC4 for disorders About MalaCards
ZCCHC4 for disorders About GeneDecksing
OMIM gene information: 611792
OMIM disorders: --
Export disorders for ZCCHC4 gene to outside databases
|
Publications
for ZCCHC4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZCCHC4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZCCHC4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Novel Sm-like proteins with long C-terminal tails and associated methyltransferases. (PubMed id 15225602)1, 2 Albrecht M. and Lengauer T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 3 Zhang Q.-H.... Chen Z. (2000)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for ZCCHC4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZCCHC4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZCCHC4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZCCHC4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZCCHC4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZCCHC4 gene:
Search GeneIP for patents involving ZCCHC4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZCCHC4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZCCHC4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZCCHC4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZCCHC4 | | | OriGene Protein Over-expression Lysate for ZCCHC4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for ZCCHC4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZCCHC4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZCCHC4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZCCHC4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZCCHC4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZCCHC4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZCCHC4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZCCHC4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZCCHC4 |
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 |  |  |  | |
| | | | Search Tocris compounds for ZCCHC4 |
| |  |  |  |  | | | | |
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 | | | ZCCHC4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCCHC4 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZCCHC4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZCCHC4 |
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