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Aliases for ZCCHC3 Gene

Aliases for ZCCHC3 Gene

  • Zinc Finger CCHC-Type Containing 3 2 3
  • Zinc Finger, CCHC Domain Containing 3 3 5
  • C20orf99 3 4
  • Chromosome 20 Open Reading Frame 99 2

External Ids for ZCCHC3 Gene

Previous HGNC Symbols for ZCCHC3 Gene

  • C20orf99

Previous GeneCards Identifiers for ZCCHC3 Gene

  • GC20P000227

Summaries for ZCCHC3 Gene

GeneCards Summary for ZCCHC3 Gene

ZCCHC3 (Zinc Finger CCHC-Type Containing 3) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and poly(A) RNA binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCCHC3 Gene

Genomics for ZCCHC3 Gene

Regulatory Elements for ZCCHC3 Gene

Promoters for ZCCHC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZCCHC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZCCHC3 Gene

Chromosome:
20
Start:
296,968 bp from pter
End:
300,321 bp from pter
Size:
3,354 bases
Orientation:
Plus strand

Genomic View for ZCCHC3 Gene

Genes around ZCCHC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZCCHC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZCCHC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCCHC3 Gene

Proteins for ZCCHC3 Gene

  • Protein details for ZCCHC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUD5-ZCHC3_HUMAN
    Recommended name:
    Zinc finger CCHC domain-containing protein 3
    Protein Accession:
    Q9NUD5
    Secondary Accessions:
    • Q3B7J3
    • Q6NT79

    Protein attributes for ZCCHC3 Gene

    Size:
    404 amino acids
    Molecular mass:
    43618 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZCCHC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZCCHC3 Gene

Proteomics data for ZCCHC3 Gene at MOPED

Post-translational modifications for ZCCHC3 Gene

  • Ubiquitination at Lys 45
  • Modification sites at PhosphoSitePlus

Other Protein References for ZCCHC3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZCCHC3 Gene

Domains & Families for ZCCHC3 Gene

Gene Families for ZCCHC3 Gene

Protein Domains for ZCCHC3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZCCHC3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NUD5

UniProtKB/Swiss-Prot:

ZCHC3_HUMAN :
  • Contains 3 CCHC-type zinc fingers.
Similarity:
  • Contains 3 CCHC-type zinc fingers.
genes like me logo Genes that share domains with ZCCHC3: view

Function for ZCCHC3 Gene

Gene Ontology (GO) - Molecular Function for ZCCHC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ZCCHC3: view
genes like me logo Genes that share phenotypes with ZCCHC3: view

Animal Model Products

miRNA for ZCCHC3 Gene

miRTarBase miRNAs that target ZCCHC3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZCCHC3 Gene

Localization for ZCCHC3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZCCHC3 Gene COMPARTMENTS Subcellular localization image for ZCCHC3 gene
Compartment Confidence
nucleus 3
cytoskeleton 2
cytosol 2
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZCCHC3 Gene

Pathways & Interactions for ZCCHC3 Gene

SuperPathways for ZCCHC3 Gene

No Data Available

Interacting Proteins for ZCCHC3 Gene

Selected Interacting proteins: Q9NUD5-ZCHC3_HUMAN for ZCCHC3 Gene via I2D

Symbol External ID(s) Details
PDPK1

Gene Ontology (GO) - Biological Process for ZCCHC3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZCCHC3 Gene

Drugs & Compounds for ZCCHC3 Gene

No Compound Related Data Available

Transcripts for ZCCHC3 Gene

mRNA/cDNA for ZCCHC3 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(202) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZCCHC3 Gene

Zinc finger, CCHC domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC3 Gene

No ASD Table

Relevant External Links for ZCCHC3 Gene

GeneLoc Exon Structure for
ZCCHC3
ECgene alternative splicing isoforms for
ZCCHC3

Expression for ZCCHC3 Gene

mRNA expression in normal human tissues for ZCCHC3 Gene

Protein differential expression in normal tissues from HIPED for ZCCHC3 Gene

This gene is overexpressed in Fetal testis (21.7), Heart (10.9), and Lung (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ZCCHC3 Gene



SOURCE GeneReport for Unigene cluster for ZCCHC3 Gene Hs.28608

genes like me logo Genes that share expression patterns with ZCCHC3: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZCCHC3 Gene

Orthologs for ZCCHC3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZCCHC3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZCCHC3 35
  • 90.58 (n)
  • 93.5 (a)
dog
(Canis familiaris)
Mammalia ZCCHC3 35
  • 91.56 (n)
  • 93.59 (a)
mouse
(Mus musculus)
Mammalia Zcchc3 35
  • 84.67 (n)
  • 85.93 (a)
Zcchc3 16
chimpanzee
(Pan troglodytes)
Mammalia ZCCHC3 35
  • 99.25 (n)
  • 99.5 (a)
rat
(Rattus norvegicus)
Mammalia Zcchc3 35
  • 84 (n)
  • 85.43 (a)
Species with no ortholog for ZCCHC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZCCHC3 Gene

ENSEMBL:
Gene Tree for ZCCHC3 (if available)
TreeFam:
Gene Tree for ZCCHC3 (if available)

Paralogs for ZCCHC3 Gene

No data available for Paralogs for ZCCHC3 Gene

Variants for ZCCHC3 Gene

Sequence variations from dbSNP and Humsavar for ZCCHC3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs2031 -- 300,165(-) ACTTA(A/G)TTGGC utr-variant-3-prime
rs14181 -- 300,027(-) CTCTA(A/G)GGTTC utr-variant-3-prime
rs1046560 -- 298,839(+) GCTTA(A/C/T)CCCTC utr-variant-3-prime
rs1046561 -- 299,130(+) GCCCC(A/C)TACCT utr-variant-3-prime
rs2223665 -- 297,874(+) GGGGA(C/T)CCGAA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ZCCHC3 Gene

Variant ID Type Subtype PubMed ID
dgv65n68 CNV Loss 17160897
nsv469544 CNV Loss 16826518

Variation tolerance for ZCCHC3 Gene

Residual Variation Intolerance Score: 18.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZCCHC3 Gene

HapMap Linkage Disequilibrium report
ZCCHC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZCCHC3 Gene

Disorders for ZCCHC3 Gene

Relevant External Links for ZCCHC3

Genetic Association Database (GAD)
ZCCHC3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZCCHC3

No disorders were found for ZCCHC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZCCHC3 Gene

Publications for ZCCHC3 Gene

  1. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  4. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  5. Proteome analysis of the HIV-1 Gag interactome. (PMID: 25010285) Engeland C.E. … KrAousslich H.G. (Virology 2014) 3

Products for ZCCHC3 Gene

Sources for ZCCHC3 Gene

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