ZCCHC3 Gene
protein-coding GIFtS: 43
GCID: GC20P000278
|
|
zinc finger, CCHC domain containing 3(Previous name: chromosome 20 open reading frame 99 )
(Previous symbol: C20orf99)
| |
Aliases
for ZCCHC3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger, CCHC Domain Containing 31 2 | | C20orf991 2 3 | | Chromosome 20 Open Reading Frame 991 | | DJ1103G7.71 | | Zinc Finger CCHC Domain-Containing Protein 32 |
Export aliases for ZCCHC3 gene to outside databasesPrevious GC identifer: GC20P000227 |
Summaries
for ZCCHC3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ZCCHC3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011387.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZCCHC3 gene promoter:
AML1a GATA-3 C/EBPalpha GATA-1 GATA-2 CHOP-10 AREB6 Max c-Myc ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZCCHC3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZCCHC3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20p13-p12.2 Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p13-p12.2ZCCHC3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P000278: view genomic region
(about GC identifiers)
Start:
|
277,737 bp from pter |
End:
|
280,965 bp from pter |
Size:
|
3,229 bases |
Orientation:
|
plus strand |
|
Proteins
for ZCCHC3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZCHC3_HUMAN, Q9NUD5 (See
protein sequence)Recommended Name: Zinc finger CCHC domain-containing protein 3 Size: 404 amino acids; 43618 Da
Secondary accessions: Q6NT79Explore the universe of human proteins at neXtProt for ZCCHC3: NX_Q9NUD5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NUD5
ZCCHC3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_149080.2
ENSEMBL proteins: ENSP00000371789
Human Recombinant Protein Products:
ZCCHC3 Antibody Products:
Assay Products for ZCCHC3: |
Protein
Domains /
Families
for ZCCHC3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZCCHC3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NUD5ProtoNet protein and cluster: Q9NUD5 1 Blocks protein family: IPB001878 C2HC-type zinc-finger signature
UniProtKB/Swiss-Prot: ZCHC3_HUMAN, Q9NUD5Similarity: Contains 3 CCHC-type zinc fingers |
Function
for ZCCHC3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZCCHC3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZCCHC3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZCCHC3 (NM_033089) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZCCHC3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZCCHC3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCCHC3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
ZCCHC3 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZCCHC3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZCCHC3
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/6 Interacting proteins for ZCCHC3 (Q9NUD53 ENSP000003717894) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
|
Drugs & Compounds
for ZCCHC3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZCCHC3
Search CenterWatch for drugs/clinical trials and news about ZCCHC3 / ZCHC3
|
Transcripts
for ZCCHC3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZCCHC3 gene: NM_033089.6 Unigene Cluster for ZCCHC3: Zinc finger, CCHC domain containing 3 Hs.28608 [show with all ESTs]Unigene Representative Sequence: BC0692381 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000382352(uc002wdf.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZCCHC3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZCCHC3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZCCHC3 (NM_033089) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZCCHC3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZCCHC3 |
Additional cDNA sequence: AK025768.1 BC036469.2 BC069238.1 BC107584.1 4 DOTS entries: DT.99953935 DT.448586 DT.95370412 DT.100027424 24/202 AceView cDNA sequences (see all 202): AA972658 AW236452 CA443293 AI248997 AI091872 BX090293 AA127715 CB068801 AI168327 AA127819 AA303130 AI183885 BU178334 AA033672 H63359 AA031613 AI216144 AA989093 BQ018739 BU733110 AW083266 AA127770 BM693876 BQ069468
GeneLoc Exon Structure
|
Expression
for ZCCHC3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZCCHC3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCCAACTAA
About this image
See ZCCHC3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZCCHC3
SOURCE GeneReport for Unigene cluster: Hs.28608
SABiosciences Custom PCR Arrays for ZCCHC3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZCCHC3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZCCHC3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZCCHC3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZCCHC3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCCHC3 |
Orthologs
for ZCCHC3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for ZCCHC3 gene from 1/6 species (see all 6) About this table
ENSEMBL Gene Tree for ZCCHC3 (if available)
TreeFam Gene Tree for ZCCHC3 (if available) |
Paralogs
for ZCCHC3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZCCHC3 gene
ZCCHC3 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for ZCCHC3
PGOHUM00000242590 PGOHUM00000239508 PGOHUM00000233632
|
Genomic Variants
for ZCCHC3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZCCHC3 (277737 - 280965 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for ZCCHC3
5 CNVs: 90424 79091 79090 2249 79092 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZCCHC3 |
|
Disorders
/ Diseases
for ZCCHC3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZCCHC3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZCCHC3 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with ZCCHC3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (2007)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
|
External Searches for ZCCHC3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZCCHC3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZCCHC3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZCCHC3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZCCHC3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZCCHC3 gene:
Search GeneIP for patents involving ZCCHC3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZCCHC3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZCCHC3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZCCHC3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZCCHC3 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZCCHC3 | | OriGene 3'-UTR Clone for ZCCHC3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZCCHC3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZCCHC3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZCCHC3 | | OriGene Custom Protein Services for ZCCHC3 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZCCHC3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZCCHC3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZCCHC3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZCCHC3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZCCHC3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZCCHC3 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ZCCHC3 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | ZCCHC3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCCHC3 |
|  |  |  | | | | ThermoFisher Antibody for ZCCHC3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZCCHC3 |
|
|
|
|
