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Aliases for ZCCHC24 Gene

Aliases for ZCCHC24 Gene

  • Zinc Finger CCHC-Type Containing 24 2 3
  • Zinc Finger, CCHC Domain Containing 24 3 5
  • C10orf56 3 4
  • Chromosome 10 Open Reading Frame 56 2
  • Zinc Finger, 3CxxC-Type 8 3
  • 3CxxC-Type 8 2
  • Zinc Finger 2
  • Z3CXXC8 3

External Ids for ZCCHC24 Gene

Previous HGNC Symbols for ZCCHC24 Gene

  • C10orf56

Previous GeneCards Identifiers for ZCCHC24 Gene

  • GC10M080813
  • GC10M081142
  • GC10M075137

Summaries for ZCCHC24 Gene

GeneCards Summary for ZCCHC24 Gene

ZCCHC24 (Zinc Finger CCHC-Type Containing 24) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and poly(A) RNA binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCCHC24 Gene

Genomics for ZCCHC24 Gene

Regulatory Elements for ZCCHC24 Gene

Enhancers for ZCCHC24 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZCCHC24 on UCSC Golden Path with GeneCards custom track

Promoters for ZCCHC24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZCCHC24 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZCCHC24 Gene

Chromosome:
10
Start:
79,382,325 bp from pter
End:
79,445,627 bp from pter
Size:
63,303 bases
Orientation:
Minus strand

Genomic View for ZCCHC24 Gene

Genes around ZCCHC24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZCCHC24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZCCHC24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCCHC24 Gene

Proteins for ZCCHC24 Gene

  • Protein details for ZCCHC24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N2G6-ZCH24_HUMAN
    Recommended name:
    Zinc finger CCHC domain-containing protein 24
    Protein Accession:
    Q8N2G6
    Secondary Accessions:
    • Q5U5T9
    • Q8TAG0

    Protein attributes for ZCCHC24 Gene

    Size:
    241 amino acids
    Molecular mass:
    26955 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH39249.1; Type=Frameshift; Positions=33; Evidence={ECO:0000305};

neXtProt entry for ZCCHC24 Gene

Proteomics data for ZCCHC24 Gene at MOPED

Post-translational modifications for ZCCHC24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZCCHC24 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZCCHC24 Gene

Domains & Families for ZCCHC24 Gene

Gene Families for ZCCHC24 Gene

Protein Domains for ZCCHC24 Gene

Suggested Antigen Peptide Sequences for ZCCHC24 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N2G6

UniProtKB/Swiss-Prot:

ZCH24_HUMAN :
  • Contains 1 CCHC-type zinc finger.
Similarity:
  • Contains 1 CCHC-type zinc finger.
genes like me logo Genes that share domains with ZCCHC24: view

Function for ZCCHC24 Gene

Gene Ontology (GO) - Molecular Function for ZCCHC24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with ZCCHC24: view
genes like me logo Genes that share phenotypes with ZCCHC24: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZCCHC24 Gene

Localization for ZCCHC24 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZCCHC24 Gene COMPARTMENTS Subcellular localization image for ZCCHC24 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 2
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZCCHC24 Gene

Pathways & Interactions for ZCCHC24 Gene

SuperPathways for ZCCHC24 Gene

No Data Available

Interacting Proteins for ZCCHC24 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000361411%0d%0a9606.ENSP00000378426%0d%0a
Selected Interacting proteins: ENSP00000361411 for ZCCHC24 Gene via STRING

Symbol External ID(s) Details
VKORC1

Gene Ontology (GO) - Biological Process for ZCCHC24 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZCCHC24 Gene

Drugs & Compounds for ZCCHC24 Gene

No Compound Related Data Available

Transcripts for ZCCHC24 Gene

mRNA/cDNA for ZCCHC24 Gene

Unigene Clusters for ZCCHC24 Gene

Zinc finger, CCHC domain containing 24:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC24 Gene

No ASD Table

Relevant External Links for ZCCHC24 Gene

GeneLoc Exon Structure for
ZCCHC24
ECgene alternative splicing isoforms for
ZCCHC24

Expression for ZCCHC24 Gene

mRNA expression in normal human tissues for ZCCHC24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZCCHC24 Gene

This gene is overexpressed in Prostate (16.7), Testis (15.8), Fetal testis (13.7), Ovary (10.6), and Fetal ovary (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZCCHC24 Gene



SOURCE GeneReport for Unigene cluster for ZCCHC24 Gene Hs.523080

genes like me logo Genes that share expression patterns with ZCCHC24: view

Protein tissue co-expression partners for ZCCHC24 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZCCHC24 Gene

Orthologs for ZCCHC24 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZCCHC24 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZCCHC24 35
  • 94.3 (n)
  • 97.86 (a)
ZCCHC24 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZCCHC24 35
  • 95.02 (n)
  • 98.34 (a)
ZCCHC24 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zcchc24 35
  • 92.12 (n)
  • 97.93 (a)
Zcchc24 16
Zcchc24 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZCCHC24 35
  • 99.45 (n)
  • 100 (a)
ZCCHC24 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zcchc24 35
  • 91.56 (n)
  • 97.51 (a)
oppossum
(Monodelphis domestica)
Mammalia ZCCHC24 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZCCHC24 35
  • 82.85 (n)
  • 91.63 (a)
ZCCHC24 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZCCHC24 36
  • 85 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zcchc24 35
  • 78.57 (n)
  • 86.55 (a)
zcchc24 36
  • 86 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y43E12A.2 36
  • 27 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12040 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6398 36
  • 72 (a)
OneToOne
Species with no ortholog for ZCCHC24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZCCHC24 Gene

ENSEMBL:
Gene Tree for ZCCHC24 (if available)
TreeFam:
Gene Tree for ZCCHC24 (if available)

Paralogs for ZCCHC24 Gene

No data available for Paralogs for ZCCHC24 Gene

Variants for ZCCHC24 Gene

Sequence variations from dbSNP and Humsavar for ZCCHC24 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs17852581 - 79,445,313(+) TCGGC(A/T)CGGGC upstream-variant-2KB, reference, missense
rs6858 -- 79,382,609(-) AGCGG(A/G)CTTAT utr-variant-3-prime
rs1610176 -- 79,399,796(+) CGGCT(G/T)CGGAA intron-variant
rs12853 -- 79,383,910(+) CTAGA(C/T)CTACC utr-variant-3-prime
rs1885433 -- 79,431,732(-) ATGGA(A/G)TCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZCCHC24 Gene

Variant ID Type Subtype PubMed ID
nsv470966 CNV Gain 18288195
nsv895744 CNV Loss 21882294
nsv467389 CNV Loss 19166990
nsv819278 CNV Loss 19587683
nsv819484 CNV Gain 19587683
esv29267 CNV Loss 19812545
esv26237 CNV Gain 19812545
esv2521292 CNV Deletion 19546169
esv2738618 CNV Deletion 23290073
esv2142846 CNV Deletion 18987734
esv1008347 CNV Deletion 20482838
esv2662195 CNV Deletion 23128226
esv2738629 CNV Deletion 23290073
esv2738640 CNV Deletion 23290073
esv2738651 CNV Deletion 23290073
esv2738662 CNV Deletion 23290073
esv2397769 CNV Deletion 18987734
esv2738673 CNV Deletion 23290073
esv2738684 CNV Deletion 23290073
esv26810 CNV Loss 19812545

Variation tolerance for ZCCHC24 Gene

Residual Variation Intolerance Score: 94.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.64% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZCCHC24 Gene

Disorders for ZCCHC24 Gene

Relevant External Links for ZCCHC24

Genetic Association Database (GAD)
ZCCHC24
Human Genome Epidemiology (HuGE) Navigator
ZCCHC24
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZCCHC24

No disorders were found for ZCCHC24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZCCHC24 Gene

Publications for ZCCHC24 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality. (PMID: 24159190) SeppAolAo I. … LehtimAoki T. (Eur. Heart J. 2014) 3
  4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. (PMID: 22681889) Baltz A.G. … Landthaler M. (Mol. Cell 2012) 3
  5. Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation. (PMID: 21103663) Schaafhausen A. … MA1ller C.R. (Thromb. Haemost. 2011) 3

Products for ZCCHC24 Gene

Sources for ZCCHC24 Gene

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