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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZCCHC24 Gene

protein-coding GIFtS: 45
GCID: GC10M081142

zinc finger, CCHC domain containing 24

(Previous name: chromosome 10 open reading frame 56 )
(Previous symbol: C10orf56)

Explore 1 disease affiliated with
ZCCHC24 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger, CCHC Domain Containing 24¹ ²
C10orf56¹ ² ³
FLJ90798¹
Chromosome 10 Open Reading Frame 56¹
Zinc Finger CCHC Domain-Containing Protein 24²

External Ids:	HGNC: 26911¹	Entrez Gene: 219654²	Ensembl: ENSG00000165424⁷	UniProtKB: Q8N2G6³

Export aliases for ZCCHC24 gene to outside databases

Previous GC identifers: GC10M080813 GC10M075137

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZCCHC24 gene promoter:
AREB6 Elk-1 CP2 AP-2beta AP-2alpha AP-2gamma C/EBPalpha AP-2alphaA Egr-4 GATA-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZCCHC24 promoter sequence

Search SABiosciences Chromatin IP Primers for ZCCHC24

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZCCHC24

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.3 Ensembl cytogenetic band: 10q22.3 HGNC cytogenetic band: 10q22.3

ZCCHC24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZCCHC24 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M081142: view genomic region (about GC identifiers)

Start:	81,142,081 bp from pter	End:	81,205,383 bp from pter
Size:	63,303 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
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About This Section

UniProtKB/Swiss-Prot: ZCH24_HUMAN, Q8N2G6 (See protein sequence)

Recommended Name: Zinc finger CCHC domain-containing protein 24

Size: 241 amino acids; 26955 Da

Sequence caution: Sequence=AAH39249.1; Type=Frameshift; Positions=33;

Secondary accessions: Q5U5T9 Q8TAG0

Explore the universe of human proteins at neXtProt for ZCCHC24: NX_Q8N2G6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8N2G6

ZCCHC24 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_699198.2

ENSEMBL proteins:

ENSP00000361411 ENSP00000361408

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZCCHC24 for domains About GeneDecksing

2 InterPro domains/families:

IPR025829 Zn_knuckle_CX2CX3GHX4C

IPR001878 Znf_CCHC

Graphical View of Domain Structure for InterPro Entry Q8N2G6

ProtoNet protein and cluster: Q8N2G6

1 Blocks protein family: IPB001878 C2HC-type zinc-finger signature

UniProtKB/Swiss-Prot: ZCH24_HUMAN, Q8N2G6

Similarity: Contains 1 CCHC-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZCCHC24 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for ZCCHC24:

Decreased TP53 protein express

Synthetic lethal with Ras

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZCCHC24

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for ZCCHC24 gene:

NM_153367.3

Unigene Cluster for ZCCHC24:

Zinc finger, CCHC domain containing 24

Hs.523080 [show with all ESTs]

Unigene Representative Sequence: BC028617

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000372336(uc010qlr.2 uc001kak.3 uc009xrw.3) ENST00000372333

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Additional cDNA sequence:

AK024784.1 AK075279.1 AK293361.1 AK303734.1 AK308876.1 AL049949.1 BC016959.1 BC028617.1

BC032450.1 BC039249.1 BC053564.1 BX648607.1

4 DOTS entries:

DT.417554 DT.102844128 DT.100029577 DT.91867043

24/279 AceView cDNA sequences (see all 279):

AI421018 BQ716605 AI888617 BM693210 BC032450 AI202227 BE207988 BU177436

BC016959 AW664457 BQ216319 AI216396 BG054590 AI678556 T34455 BQ641715

AA916989 BQ723497 BF939567 BM725864 BF725996 N47249 BE205868 BQ575746

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZCCHC24 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGTATTAAA

About this image

ZCCHC24 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Sclerotome cells (Primary Cell)

Bone, Cartilage, Somite

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ZCCHC24 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZCCHC24

SOURCE GeneReport for Unigene cluster: Hs.523080

SABiosciences Custom PCR Arrays for ZCCHC24

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ZCCHC24 gene from 6/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Zcchc24^{1 , 5}	zinc finger, CCHC domain containing 24^{1, 5}	92.12(n)¹ 97.93(a)¹		14 (15.06 cM)⁵ 71918¹ NM_001101433.1¹ NP_001094903.1¹ 25711640⁵
chicken (Gallus gallus)	Aves	ZCCHC24¹	zinc finger, CCHC domain containing 24	83.12(n) 91.63(a)		423722 XM_421599.3 XP_421599.2
lizard (Anolis carolinensis)	Reptilia	ZCCHC24⁶	--	100(a)	1 ↔ 1	GL343495.1(45505-57919)
zebrafish (Danio rerio)	Actinopterygii	zcchc24¹	zinc finger, CCHC domain containing 24	78.71(n) 86.55(a)		562028 NM_001098388.1 NP_001091858.1
honey bee (Apis mellifera)	Insecta	--	--	57(a)	1 ↔ 1	GroupUn.505(14260-15932)
worm (Caenorhabditis elegans)	Secernentea	Y43E12A.2⁶	Protein Y43E12A.2	24(a)	1 ↔ 1	IV(10982047-10984982)

ENSEMBL Gene Tree for ZCCHC24 (if available)
TreeFam Gene Tree for ZCCHC24 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs143081719^1,2		--	81141649(+)	`GGGCCC/TCTGCC`	1	--	ds500¹		0	--	--	--	--
rs144748550^1,2		--	81141659(+)	`CCCGTC/TTCCCC`	1	--	ds500¹		0	--	--	--	--
rs148083375^1,2		--	81141668(+)	`CCTGGA/GCTGAT`	1	--	ds500¹		0	--	--	--	--
rs150798026^1,2		--	81141980(+)	`GAGCTA/GAGGCC`	1	--	ds500¹		0	--	--	--	--
rs7909640^1,2	H	--	81141996(+)	`CAAGTC/TTCTCT`	1	--	ds500¹		4		NS EA	420
rs7085536^1,2	C,F,A,H,	--	81142048(+)	`CCTACA/GTGCTT`	1	--	ds500¹		15		NA NS EA WA	1358
rs139364160^1,2		--	81142056(+)	`CTTGCG/TTGAAC`	1	--	ds500¹		0	--	--	--	--
rs80126415^1,2	C,F,	--	81142085(+)	`CTTTTG/ACTTTT`	1	--	ut3¹		1		WA	118
rs6480934^1,2	C,F,A,H,	--	81142209(+)	`GACGTC/TGGAGC`	1	--	ut3¹ ese³		7		NS EA NA	562
rs11002951^1,2	C,F,H,	--	81142245(+)	`GCCCAC/TGGGTT`	1	--	ut3¹ ese³		19		NS EA NA WA	2112

HapMap Linkage Disequilibrium report for ZCCHC24 (81142081 - 81205383 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for ZCCHC24
5 CNVs: 71054 58472 71055 65730 100992
3 Indels: 44787 39762 58471

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZCCHC24 for disorders About GeneDecksing

1 disease for ZCCHC24: About MalaCards

alzheimer's disease

Human Genome Epidemiology (HuGE) Navigator: ZCCHC24 (2 documents)

Export disorders for ZCCHC24 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZCCHC24 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZCCHC24)

Utopia: connect your pdf to the dynamic
world of online information

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{1, 2} Deloukas P.... Rogers J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)² Mayya V.... Han D.K. (2009)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)
A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)¹ Grupe A....Goate A. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 219654	HGNC: 26911	AceView: C10orf56	Ensembl:ENSG00000165424	euGenes: HUgn219654
ECgene: ZCCHC24	H-InvDB: ZCCHC24

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZCCHC24	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZCCHC24 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZCCHC24 gene:
Search GeneIP for patents involving ZCCHC24

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZCCHC24 gene at Home site.

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ZCCHC24 Gene

zinc finger, CCHC domain containing 24

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ZCCHC24 Gene

zinc finger, CCHC domain containing 24

Aliasesfor ZCCHC24 gene

Summariesfor ZCCHC24 gene

Genomic Viewsfor ZCCHC24 gene

Proteinsfor ZCCHC24 gene

Protein Domains /Familiesfor ZCCHC24 gene

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