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Aliases for ZCCHC24 Gene

Aliases for ZCCHC24 Gene

  • Zinc Finger CCHC-Type Containing 24 2 3 5
  • Zinc Finger, 3CxxC-Type 8 2 3
  • C10orf56 3 4
  • Zinc Finger CCHC Domain-Containing Protein 24 3
  • Zinc Finger, CCHC Domain Containing 24 3
  • Chromosome 10 Open Reading Frame 56 2
  • Z3CXXC8 3

External Ids for ZCCHC24 Gene

Previous HGNC Symbols for ZCCHC24 Gene

  • C10orf56

Previous GeneCards Identifiers for ZCCHC24 Gene

  • GC10M080813
  • GC10M081142
  • GC10M075137

Summaries for ZCCHC24 Gene

GeneCards Summary for ZCCHC24 Gene

ZCCHC24 (Zinc Finger CCHC-Type Containing 24) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and poly(A) RNA binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCCHC24 Gene

Genomics for ZCCHC24 Gene

Regulatory Elements for ZCCHC24 Gene

Enhancers for ZCCHC24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F079396 1.5 FANTOM5 Ensembl ENCODE 14 +40.3 40338 18.2 HDGF PKNOX1 ARID4B SIN3A FEZF1 ZNF48 YY1 ZNF121 GLIS2 ZNF263 ZCCHC24 ENSG00000235426 ENSG00000272489 TMEM254-AS1 GC10M079406
GH10F079419 1.2 FANTOM5 Ensembl ENCODE 13.4 +24.3 24308 3.9 CTCF KLF1 SIN3A ZIC2 RAD21 YY1 GATA3 ZNF366 FOS MAFK ZCCHC24 ENSG00000235426 BEND3P3 LOC105378382
GH10F079466 1.1 Ensembl ENCODE 13.3 -22.2 -22180 2.8 CBX3 ZNF2 RAD21 YY1 ZNF121 ZNF143 EGR2 ZNF362 ZNF654 CEBPB BEND3P3 ZCCHC24 ENSG00000235426 ENSG00000235705 LOC105378383 TPRX1P1
GH10F079417 0.2 Ensembl 13.3 +28.1 28127 0.2 MYC ZCCHC24 ENSG00000235426 SFTPD LOC105378382 GC10M079406
GH10F079415 0.2 Ensembl 13.3 +29.7 29727 0.2 ZCCHC24 ENSG00000235426 LOC105378382 GC10M079406
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZCCHC24 on UCSC Golden Path with GeneCards custom track

Promoters for ZCCHC24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000221461 27 2801 HDGF PKNOX1 ARNT CREB3L1 SIN3A YBX1 FEZF1 ZNF2 YY1 KLF13

Genomic Location for ZCCHC24 Gene

Chromosome:
10
Start:
79,382,325 bp from pter
End:
79,445,627 bp from pter
Size:
63,303 bases
Orientation:
Minus strand

Genomic View for ZCCHC24 Gene

Genes around ZCCHC24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZCCHC24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZCCHC24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCCHC24 Gene

Proteins for ZCCHC24 Gene

  • Protein details for ZCCHC24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N2G6-ZCH24_HUMAN
    Recommended name:
    Zinc finger CCHC domain-containing protein 24
    Protein Accession:
    Q8N2G6
    Secondary Accessions:
    • Q5U5T9
    • Q8TAG0

    Protein attributes for ZCCHC24 Gene

    Size:
    241 amino acids
    Molecular mass:
    26955 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH39249.1; Type=Frameshift; Positions=33; Evidence={ECO:0000305};

neXtProt entry for ZCCHC24 Gene

Post-translational modifications for ZCCHC24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZCCHC24 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZCCHC24 Gene

Domains & Families for ZCCHC24 Gene

Gene Families for ZCCHC24 Gene

Protein Domains for ZCCHC24 Gene

Suggested Antigen Peptide Sequences for ZCCHC24 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N2G6

UniProtKB/Swiss-Prot:

ZCH24_HUMAN :
  • Contains 1 CCHC-type zinc finger.
Similarity:
  • Contains 1 CCHC-type zinc finger.
genes like me logo Genes that share domains with ZCCHC24: view

Function for ZCCHC24 Gene

Gene Ontology (GO) - Molecular Function for ZCCHC24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZCCHC24: view
genes like me logo Genes that share phenotypes with ZCCHC24: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZCCHC24 Gene

Localization for ZCCHC24 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZCCHC24 Gene COMPARTMENTS Subcellular localization image for ZCCHC24 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 2
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZCCHC24 Gene

Pathways & Interactions for ZCCHC24 Gene

SuperPathways for ZCCHC24 Gene

No Data Available

Interacting Proteins for ZCCHC24 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000361411%0d%0a9606.ENSP00000378426%0d%0a
Selected Interacting proteins: ENSP00000361411 Q8N2G6-ZCH24_HUMAN for ZCCHC24 Gene via STRING IID

Gene Ontology (GO) - Biological Process for ZCCHC24 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZCCHC24 Gene

Transcripts for ZCCHC24 Gene

mRNA/cDNA for ZCCHC24 Gene

Unigene Clusters for ZCCHC24 Gene

Zinc finger, CCHC domain containing 24:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC24 Gene

No ASD Table

Relevant External Links for ZCCHC24 Gene

GeneLoc Exon Structure for
ZCCHC24
ECgene alternative splicing isoforms for
ZCCHC24

Expression for ZCCHC24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZCCHC24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZCCHC24 Gene

This gene is overexpressed in Prostate (16.7), Testis (15.8), Fetal testis (13.7), Ovary (10.6), and Fetal ovary (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZCCHC24 Gene



Protein tissue co-expression partners for ZCCHC24 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZCCHC24 Gene:

ZCCHC24

SOURCE GeneReport for Unigene cluster for ZCCHC24 Gene:

Hs.523080
genes like me logo Genes that share expression patterns with ZCCHC24: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZCCHC24 Gene

Orthologs for ZCCHC24 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZCCHC24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZCCHC24 34 35
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia ZCCHC24 34 35
  • 95.02 (n)
oppossum
(Monodelphis domestica)
Mammalia ZCCHC24 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZCCHC24 34 35
  • 94.3 (n)
mouse
(Mus musculus)
Mammalia Zcchc24 34 16 35
  • 92.12 (n)
rat
(Rattus norvegicus)
Mammalia Zcchc24 34
  • 91.56 (n)
chicken
(Gallus gallus)
Aves ZCCHC24 34 35
  • 82.85 (n)
lizard
(Anolis carolinensis)
Reptilia ZCCHC24 35
  • 85 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zcchc24 34 35
  • 78.57 (n)
worm
(Caenorhabditis elegans)
Secernentea Y43E12A.2 35
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6398 35
  • 72 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12040 34
Species where no ortholog for ZCCHC24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZCCHC24 Gene

ENSEMBL:
Gene Tree for ZCCHC24 (if available)
TreeFam:
Gene Tree for ZCCHC24 (if available)

Paralogs for ZCCHC24 Gene

No data available for Paralogs for ZCCHC24 Gene

Variants for ZCCHC24 Gene

Sequence variations from dbSNP and Humsavar for ZCCHC24 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1006193 -- 79,399,499(-) GCCCA(A/G)GCTCC intron-variant
rs10160149 -- 79,437,542(+) CCCTG(A/T)TATAT intron-variant
rs10458643 -- 79,392,512(+) CCCCC(A/G)TTTTG intron-variant
rs1046444 -- 79,385,945(-) ACCAG(C/G)CAGGC utr-variant-3-prime
rs1046445 -- 79,385,886(-) CTCTC(A/G)GAAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZCCHC24 Gene

Variant ID Type Subtype PubMed ID
dgv1279n54 CNV loss 21841781
dgv483n106 CNV deletion 24896259
esv1008347 CNV deletion 20482838
esv2142846 CNV deletion 18987734
esv2397769 CNV deletion 18987734
esv2521292 CNV deletion 19546169
esv26237 CNV gain 19812545
esv2662195 CNV deletion 23128226
esv26810 CNV loss 19812545
esv2738618 CNV deletion 23290073
esv2738629 CNV deletion 23290073
esv2738640 CNV deletion 23290073
esv2738651 CNV deletion 23290073
esv2738662 CNV deletion 23290073
esv2738673 CNV deletion 23290073
esv2738684 CNV deletion 23290073
esv29267 CNV loss 19812545
esv3546547 CNV deletion 23714750
esv3623910 CNV gain 21293372
esv3623911 CNV gain 21293372
esv3623912 CNV loss 21293372
nsv1069501 CNV deletion 25765185
nsv1119831 CNV deletion 24896259
nsv1161981 CNV duplication 26073780
nsv467389 CNV loss 19166990
nsv470966 CNV gain 18288195
nsv551589 CNV loss 21841781
nsv551590 CNV loss 21841781
nsv551591 CNV gain 21841781
nsv819278 CNV loss 19587683
nsv819484 CNV gain 19587683
nsv948080 CNV duplication 23825009

Variation tolerance for ZCCHC24 Gene

Residual Variation Intolerance Score: 94.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZCCHC24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZCCHC24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZCCHC24 Gene

Disorders for ZCCHC24 Gene

Relevant External Links for ZCCHC24

Genetic Association Database (GAD)
ZCCHC24
Human Genome Epidemiology (HuGE) Navigator
ZCCHC24
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZCCHC24

No disorders were found for ZCCHC24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZCCHC24 Gene

Publications for ZCCHC24 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64

Products for ZCCHC24 Gene

Sources for ZCCHC24 Gene

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