Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZCCHC2 Gene

Aliases for ZCCHC2 Gene

  • Zinc Finger CCHC-Type Containing 2 2 3 5
  • Zinc Finger CCHC Domain-Containing Protein 2 3
  • Zinc Finger, CCHC Domain Containing 2 3
  • Chromosome 18 Open Reading Frame 49 2
  • C18orf49 3
  • KIAA1744 4

External Ids for ZCCHC2 Gene

Previous HGNC Symbols for ZCCHC2 Gene

  • C18orf49

Previous GeneCards Identifiers for ZCCHC2 Gene

  • GC18P059975
  • GC18P058339
  • GC18P058340
  • GC18P058342
  • GC18P058357
  • GC18P060190
  • GC18P056901

Summaries for ZCCHC2 Gene

GeneCards Summary for ZCCHC2 Gene

ZCCHC2 (Zinc Finger CCHC-Type Containing 2) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and phosphatidylinositol binding. An important paralog of this gene is ZCCHC14.

Gene Wiki entry for ZCCHC2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCCHC2 Gene

Genomics for ZCCHC2 Gene

Regulatory Elements for ZCCHC2 Gene

Enhancers for ZCCHC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G062521 1.8 FANTOM5 ENCODE dbSUPER 13.9 +1.9 1860 7.1 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC ZCCHC2 KIAA1468 LOC100422317 PHLPP1 TNFRSF11A ENSG00000278017
GH18G063197 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +675.9 675919 3.6 HDGF PKNOX1 ATF1 ZNF493 ZNF133 GLI4 ZNF2 ZNF548 YY2 ZNF488 ENSG00000267560 ZCCHC2 BCL2 VPS4B PHLPP1 ENSG00000283125 GC18P063159
GH18G062450 1.7 FANTOM5 Ensembl ENCODE 10.6 -71.3 -71331 3.2 PKNOX1 FOXA2 CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 FOS ZCCHC2 KIAA1468 ACTBP9 GC18P062511
GH18G062505 1.7 FANTOM5 Ensembl ENCODE dbSUPER 8.7 -16.9 -16851 2.1 ESRRA IRF2 ASH2L ZMYM3 CEBPG ZNF384 RAD21 ARID3A POLR2A STAT2 ZCCHC2 KIAA1468 GC18P062511 ACTBP9
GH18G062554 0.8 ENCODE 17.5 +31.9 31877 1.1 TAL1 JUN FOSL1 TCF12 ZNF316 GATA2 NCOR1 TRIM24 NFE2 FOS ZCCHC2 ENSG00000279236 RN7SL705P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZCCHC2 on UCSC Golden Path with GeneCards custom track

Promoters for ZCCHC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000104377 1593 5601 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC

Genomic Location for ZCCHC2 Gene

Chromosome:
18
Start:
62,523,007 bp from pter
End:
62,587,709 bp from pter
Size:
64,703 bases
Orientation:
Plus strand

Genomic View for ZCCHC2 Gene

Genes around ZCCHC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZCCHC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZCCHC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCCHC2 Gene

Proteins for ZCCHC2 Gene

  • Protein details for ZCCHC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0B9-ZCHC2_HUMAN
    Recommended name:
    Zinc finger CCHC domain-containing protein 2
    Protein Accession:
    Q9C0B9
    Secondary Accessions:
    • B2RPG6
    • Q8N3S1
    • Q9NXF6

    Protein attributes for ZCCHC2 Gene

    Size:
    1178 amino acids
    Molecular mass:
    125936 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91057.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZCCHC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZCCHC2 Gene

Post-translational modifications for ZCCHC2 Gene

  • Ubiquitination at isoforms=203
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZCCHC2 Gene

Domains & Families for ZCCHC2 Gene

Gene Families for ZCCHC2 Gene

Protein Domains for ZCCHC2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZCCHC2: view

No data available for UniProtKB/Swiss-Prot for ZCCHC2 Gene

Function for ZCCHC2 Gene

Gene Ontology (GO) - Molecular Function for ZCCHC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0035091 phosphatidylinositol binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZCCHC2: view
genes like me logo Genes that share phenotypes with ZCCHC2: view

Animal Model Products

CRISPR Products

miRNA for ZCCHC2 Gene

miRTarBase miRNAs that target ZCCHC2

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZCCHC2 Gene

Localization for ZCCHC2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZCCHC2 gene
Compartment Confidence
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for ZCCHC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ZCCHC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZCCHC2 Gene

Pathways & Interactions for ZCCHC2 Gene

SuperPathways for ZCCHC2 Gene

No Data Available

Interacting Proteins for ZCCHC2 Gene

Selected Interacting proteins: Q9C0B9-ZCHC2_HUMAN for ZCCHC2 Gene via IID

Symbol External ID(s) Details
MC4R

Gene Ontology (GO) - Biological Process for ZCCHC2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZCCHC2 Gene

Drugs & Compounds for ZCCHC2 Gene

No Compound Related Data Available

Transcripts for ZCCHC2 Gene

mRNA/cDNA for ZCCHC2 Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZCCHC2 Gene

Zinc finger, CCHC domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16
SP1: - - - -
SP2: -
SP3:
SP4: - - - -
SP5: - -
SP6:

Relevant External Links for ZCCHC2 Gene

GeneLoc Exon Structure for
ZCCHC2
ECgene alternative splicing isoforms for
ZCCHC2

Expression for ZCCHC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZCCHC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZCCHC2 Gene

This gene is overexpressed in Urine (40.1), Bone (14.5), and Lung (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZCCHC2 Gene



Protein tissue co-expression partners for ZCCHC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZCCHC2 Gene:

ZCCHC2

SOURCE GeneReport for Unigene cluster for ZCCHC2 Gene:

Hs.114191

Evidence on tissue expression from TISSUES for ZCCHC2 Gene

  • Muscle(4.3)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZCCHC2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZCCHC2 Gene

Orthologs for ZCCHC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZCCHC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZCCHC2 34 35
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia ZCCHC2 34 35
  • 89.38 (n)
mouse
(Mus musculus)
Mammalia Zcchc2 34 16 35
  • 88.28 (n)
rat
(Rattus norvegicus)
Mammalia Zcchc2 34
  • 87.83 (n)
cow
(Bos Taurus)
Mammalia ZCCHC2 34
  • 83.2 (n)
oppossum
(Monodelphis domestica)
Mammalia ZCCHC2 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZCCHC2 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZCCHC2 34 35
  • 77.51 (n)
lizard
(Anolis carolinensis)
Reptilia ZCCHC2 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zcchc2 34
  • 63.7 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30746 34
zebrafish
(Danio rerio)
Actinopterygii si:ch211-273d2.3 34
  • 53.26 (n)
ZCCHC2 35
  • 34 (a)
OneToOne
Species where no ortholog for ZCCHC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZCCHC2 Gene

ENSEMBL:
Gene Tree for ZCCHC2 (if available)
TreeFam:
Gene Tree for ZCCHC2 (if available)

Paralogs for ZCCHC2 Gene

Paralogs for ZCCHC2 Gene

Pseudogenes.org Pseudogenes for ZCCHC2 Gene

genes like me logo Genes that share paralogs with ZCCHC2: view

Variants for ZCCHC2 Gene

Sequence variations from dbSNP and Humsavar for ZCCHC2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000073892 -- 62,557,257(+) GGCGT(C/G)TCCTT intron-variant
rs1000205490 -- 62,546,408(+) TATTT(A/C)TTTCT intron-variant
rs1000225876 -- 62,563,950(+) GGCCT(C/T)GCAGA intron-variant
rs1000375615 -- 62,582,511(+) CGAAT(C/G)TACCA intron-variant
rs1000380159 -- 62,540,188(+) ACAAA(A/T)CCATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZCCHC2 Gene

Variant ID Type Subtype PubMed ID
dgv5966n54 CNV loss 21841781
dgv5967n54 CNV loss 21841781
dgv5968n54 CNV loss 21841781
esv26655 CNV loss 19812545
esv3445976 CNV duplication 20981092
nsv1126487 CNV deletion 24896259
nsv2333 CNV deletion 18451855
nsv577087 CNV gain+loss 21841781
nsv577089 CNV loss 21841781
nsv828259 CNV gain 20364138

Variation tolerance for ZCCHC2 Gene

Residual Variation Intolerance Score: 12.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.23; 52.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZCCHC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZCCHC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZCCHC2 Gene

Disorders for ZCCHC2 Gene

Relevant External Links for ZCCHC2

Genetic Association Database (GAD)
ZCCHC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZCCHC2

No disorders were found for ZCCHC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZCCHC2 Gene

Publications for ZCCHC2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Discovery and fine mapping of serum protein loci through transethnic meta-analysis. (PMID: 23022100) Franceschini N. … Morris A.P. (Am. J. Hum. Genet. 2012) 3 64
  4. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 4 64
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64

Products for ZCCHC2 Gene

Sources for ZCCHC2 Gene

Content
Loading form....