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Aliases for ZCCHC18 Gene

Aliases for ZCCHC18 Gene

  • Zinc Finger CCHC-Type Containing 18 2 3 5
  • Zinc Finger, CCHC Domain Containing 12 Pseudogene 1 2 3
  • Paraneoplastic Ma Antigen Family Member 7B 2 3
  • Putative Zinc Finger CCHC Domain-Containing Protein 18 3
  • Zinc Finger CCHC Domain-Containing Protein 18 3
  • PNMA7B 3
  • SIZN2 3

External Ids for ZCCHC18 Gene

Previous GeneCards Identifiers for ZCCHC18 Gene

  • GC0XP103244
  • GC0XP103356

Summaries for ZCCHC18 Gene

GeneCards Summary for ZCCHC18 Gene

ZCCHC18 (Zinc Finger CCHC-Type Containing 18) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZCCHC12.

Additional gene information for ZCCHC18 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCCHC18 Gene

Genomics for ZCCHC18 Gene

GeneHancer (GH) Regulatory Elements for ZCCHC18 Gene

Promoters and enhancers for ZCCHC18 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI104108 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -1.1 -1081 5.5 PKNOX1 SIN3A RAD21 ZNF335 GLIS2 ZNF366 SCRT2 EGR2 ZNF654 ZBTB11 ZCCHC18 H2BFM FAM199X SLC25A53 LOC101060236
GH0XI103151 Enhancer 1.2 Ensembl ENCODE 13.1 -959.8 -959822 1.3 ARNT NEUROD1 FEZF1 GLI4 BRCA1 ZNF2 ZBTB7B TCF12 ZNF121 GLIS2 GPRASP1 BEX4 TCEAL3 ELF2P1 TMSB15B ZCCHC18 GPRASP2 BEX3 TCEAL7 TCEAL1
GH0XI103690 Enhancer 0.6 dbSUPER 4.4 -418.5 -418513 7.1 SOX5 SOX13 FOXA2 FOXA3 RARA TBX3 SKI TCF7 SMAD4 PLP1 TCEAL3 BEX4 BEX2 ZCCHC18 BEX3 MORF4L2 MORF4L2-AS1 TMEM31
GH0XI104098 Enhancer 0.6 ENCODE 0.4 -13.8 -13799 0.2 CTCF CLOCK ZNF654 TRIM22 REST ELF1 RAD21 SMC3 PRDM10 TRIM28 ZCCHC18 LOC101060236
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZCCHC18 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZCCHC18 gene promoter:

Genomic Locations for ZCCHC18 Gene

Genomic Locations for ZCCHC18 Gene
chrX:104,112,131-104,115,847
(GRCh38/hg38)
Size:
3,717 bases
Orientation:
Plus strand
chrX:103,356,822-103,360,533
(GRCh37/hg19)

Genomic View for ZCCHC18 Gene

Genes around ZCCHC18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZCCHC18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZCCHC18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCCHC18 Gene

Proteins for ZCCHC18 Gene

  • Protein details for ZCCHC18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG32-ZCC18_HUMAN
    Recommended name:
    Zinc finger CCHC domain-containing protein 18
    Protein Accession:
    P0CG32

    Protein attributes for ZCCHC18 Gene

    Size:
    403 amino acids
    Molecular mass:
    45160 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZCCHC18 Gene

Post-translational modifications for ZCCHC18 Gene

No Post-translational modifications

Other Protein References for ZCCHC18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZCCHC18 Gene

Domains & Families for ZCCHC18 Gene

Gene Families for ZCCHC18 Gene

Protein Domains for ZCCHC18 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZCCHC18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CG32

UniProtKB/Swiss-Prot:

ZCC18_HUMAN :
  • Belongs to the ZCCHC12 family.
Family:
  • Belongs to the ZCCHC12 family.
genes like me logo Genes that share domains with ZCCHC18: view

Function for ZCCHC18 Gene

Gene Ontology (GO) - Molecular Function for ZCCHC18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZCCHC18: view

Animal Model Products

miRNA for ZCCHC18 Gene

miRTarBase miRNAs that target ZCCHC18

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZCCHC18 Gene

Localization for ZCCHC18 Gene

Gene Ontology (GO) - Cellular Components for ZCCHC18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016607 nuclear speck IBA --
genes like me logo Genes that share ontologies with ZCCHC18: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for ZCCHC18 Gene

Pathways & Interactions for ZCCHC18 Gene

SuperPathways for ZCCHC18 Gene

No Data Available

Interacting Proteins for ZCCHC18 Gene

Gene Ontology (GO) - Biological Process for ZCCHC18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030509 BMP signaling pathway IBA --
genes like me logo Genes that share ontologies with ZCCHC18: view

No data available for Pathways by source and SIGNOR curated interactions for ZCCHC18 Gene

Drugs & Compounds for ZCCHC18 Gene

No Compound Related Data Available

Transcripts for ZCCHC18 Gene

mRNA/cDNA for ZCCHC18 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZCCHC18 Gene

Zinc finger, CCHC domain containing 18:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC18 Gene

No ASD Table

Relevant External Links for ZCCHC18 Gene

GeneLoc Exon Structure for
ZCCHC18
ECgene alternative splicing isoforms for
ZCCHC18

Expression for ZCCHC18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZCCHC18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of ZCCHC18 Gene:

ZCCHC18

SOURCE GeneReport for Unigene cluster for ZCCHC18 Gene:

Hs.648338
genes like me logo Genes that share expression patterns with ZCCHC18: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZCCHC18 Gene

Orthologs for ZCCHC18 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZCCHC18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZCCHC18 33
  • 99.5 (n)
cow
(Bos Taurus)
Mammalia ZCCHC18 33
  • 86.18 (n)
dog
(Canis familiaris)
Mammalia LOC492040 33
  • 84.94 (n)
rat
(Rattus norvegicus)
Mammalia Zcchc18 33
  • 80.43 (n)
mouse
(Mus musculus)
Mammalia Zcchc18 33 16 34
  • 78.09 (n)
Zcchc12 34
  • 72 (a)
ManyToMany
Species where no ortholog for ZCCHC18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZCCHC18 Gene

ENSEMBL:
Gene Tree for ZCCHC18 (if available)
TreeFam:
Gene Tree for ZCCHC18 (if available)

Paralogs for ZCCHC18 Gene

(3) SIMAP similar genes for ZCCHC18 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZCCHC18: view

Variants for ZCCHC18 Gene

Sequence variations from dbSNP and Humsavar for ZCCHC18 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000582685 -- 104,120,809(+) A/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1002087346 -- 104,120,224(+) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1003209440 -- 104,117,971(+) C/G/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1003766041 -- 104,117,524(+) C/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1004380129 -- 104,113,998(+) T/C 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZCCHC18 Gene

Variant ID Type Subtype PubMed ID
esv2758880 CNV gain 17122850
nsv469772 CNV gain 16826518
nsv519626 CNV gain 19592680
nsv7453 OTHER inversion 18451855

Variation tolerance for ZCCHC18 Gene

Residual Variation Intolerance Score: 78.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.50; 55.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZCCHC18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZCCHC18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZCCHC18 Gene

Disorders for ZCCHC18 Gene

Additional Disease Information for ZCCHC18

No disorders were found for ZCCHC18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZCCHC18 Gene

Publications for ZCCHC18 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  2. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 58
  3. Identification of proteins that interact with murine cytomegalovirus early protein M112-113 in brain. (PMID: 22340173) Wang H … Fang F (Chinese medical journal 2011) 3 58
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R … Stanton LW (Nature biotechnology 2004) 3 58

Products for ZCCHC18 Gene

Sources for ZCCHC18 Gene

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