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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZCCHC18 Gene

protein-coding   GIFtS: 34
GCID: GC0XP103356

zinc finger, CCHC domain containing 18

(Previous names: zinc finger, CCHC domain containing 12 pseudogene 1 )
  Search for ZCCHC18
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Biological research products
for ZCCHC18    

Aliases
for ZCCHC18 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger, CCHC Domain Containing 181 2     Paraneoplastic Ma Antigen Family Member 7B2
PNMA7B1 2     Putative Zinc Finger CCHC Domain-Containing Protein 182
SIZN21 2     Zinc Finger, CCHC Domain Containing 18 Pseudogene2
Zinc Finger, CCHC Domain Containing 12 Pseudogene 11 2     

External Ids:    HGNC: 324591   Entrez Gene: 6443532   Ensembl: ENSG000001667077   UniProtKB: P0CG323   
ORGUL members:         
NONCODE:n407226    

Export aliases for ZCCHC18 gene to outside databases

Previous GC identifer: GC0XP103244


Summaries
for ZCCHC18 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for ZCCHC18 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011651.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZCCHC18 gene promoter:
         STAT5B   AP-1   XBP-1   STAT5A   NF-E2 p45   POU2F1   GATA-6   POU2F1a   Zic3   NF-E2   
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZCCHC18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.2   Ensembl cytogenetic band:  Xq22.2   HGNC cytogenetic band: Xq22.2

ZCCHC18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZCCHC18 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP103356:  view genomic region     (about GC identifiers)

Start:
 103,356,822 bp from pter      End:
 103,360,533 bp from pter
Size:
 3,712 bases      Orientation:
 plus strand

Proteins
for ZCCHC18 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ZCC18_HUMAN, P0CG32 (See protein sequence)
Recommended Name: Putative zinc finger CCHC domain-containing protein 18  
Size: 403 amino acids; 45160 Da
Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for ZCCHC18: NX_P0CG32

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P0CG32

    • ZCCHC18 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001137450.1  
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    Protein Domains /
    Families
    for ZCCHC18 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ZCCHC18 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001878 Znf_CCHC

    Graphical View of Domain Structure for InterPro Entry P0CG32

    ProtoNet protein and cluster: P0CG32

    UniProtKB/Swiss-Prot: ZCC18_HUMAN, P0CG32
    Similarity: Belongs to the ZCCHC12 family
    Similarity: Contains 1 CCHC-type zinc finger


    Function
    for ZCCHC18 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0008270zinc ion binding IEA--


    ZCCHC18 for ontologies           About GeneDecksing



    Pathways & Interactions
    for ZCCHC18 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZCCHC18

    Drugs & Compounds
    for ZCCHC18 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ZCCHC18
    Search CenterWatch for drugs/clinical trials and news about ZCCHC18 / ZCC18 

    Transcripts
    for ZCCHC18 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section
    REFSEQ mRNAs for ZCCHC18 gene: 
    NM_001143978.1  

    Unigene Cluster for ZCCHC18:

    Zinc finger, CCHC domain containing 18
    Hs.648338  [show with all ESTs]
    Unigene Representative Sequence: NM_001143978
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000422784(lincRNA) ENST00000423478(lincRNA) ENST00000537356(lincRNA)(uc011msg.2 uc011msh.2)


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    Additional cDNA sequence: 

    AF086548.1 NR_026694.1 

    4 DOTS entries:

    DT.306706  DT.97835270  DT.91845332  DT.121303046 

    GeneLoc Exon Structure


    Expression
    for ZCCHC18 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZCCHC18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTCTATTTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ZCCHC18 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbZeugopodMesenchymal Condensate CellsBone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ZCCHC18 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZCCHC18

    SOURCE GeneReport for Unigene cluster: Hs.648338
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    In Situ
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    Orthologs
    for ZCCHC18 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZCCHC18 gene from 1/3 species (see all 3)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Zcchc181 , 5 zinc finger, CCHC domain containing 181, 5 78.18(n)1
    68.54(a)1    		   X (59.10 cM)5
    669951  NM_025893.21  NP_080169.21 
     1369931555 


    ENSEMBL Gene Tree for ZCCHC18 (if available)
    TreeFam Gene Tree for ZCCHC18 (if available) 

    Paralogs
    for ZCCHC18 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for ZCCHC18 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ZCCHC18
         2 CNVs: 4160 52903
    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for ZCCHC18 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for ZCCHC18 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZCCHC18 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZCCHC18)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)

    External Searches for ZCCHC18 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ZCCHC18 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 644353 HGNC: 32459 Ensembl:ENSG00000166707 euGenes: HUgn644353 ECgene: ZCCHC18
    H-InvDB: ZCCHC18

    Other Databases showing ZCCHC18 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ZCCHC18 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZCCHC18 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ZCCHC18 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ZCCHC18 gene:
    Search GeneIP for patents involving ZCCHC18

    GeneCards and IP:
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    About This Section

     
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