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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZCCHC18 Gene

protein-coding   GIFtS: 34
GCID: GC0XP103356

Zinc Finger, CCHC Domain Containing 18

(Previous names: zinc finger, CCHC domain containing 12 pseudogene 1)
  Search for ZCCHC18
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger, CCHC Domain Containing 181 2
Zinc Finger, CCHC Domain Containing 12 Pseudogene 11 2
Paraneoplastic Ma Antigen Family Member 7B1 2
PNMA7B2
SIZN22
Putative Zinc Finger CCHC Domain-Containing Protein 182

External Ids:    HGNC: 324591   Entrez Gene: 6443532   Ensembl: ENSG000001667077   UniProtKB: P0CG323   
ORGUL members:         
NONCODE14:n407226      

Export aliases for ZCCHC18 gene to outside databases

Previous GC identifer: GC0XP103244


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZCCHC18 Gene: 
ZCCHC18 (zinc finger, CCHC domain containing 18) is a protein-coding gene, and is affiliated with the lncRNA class. GO annotations related to this gene include zinc ion binding and nucleic acid binding. An important paralog of this gene is PNMA6A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_011651.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZCCHC18 gene promoter:
         STAT5B   AP-1   XBP-1   STAT5A   NF-E2 p45   POU2F1   GATA-6   POU2F1a   Zic3   NF-E2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZCCHC18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZCCHC18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.2   Ensembl cytogenetic band:  Xq22.2   HGNC cytogenetic band: Xq22.2

ZCCHC18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZCCHC18 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP103356:  view genomic region     (about GC identifiers)

Start:
103,356,822 bp from pter      End:
103,360,533 bp from pter
Size:
3,712 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZCC18_HUMAN, P0CG32 (See protein sequence)
Recommended Name: Putative zinc finger CCHC domain-containing protein 18  
Size: 403 amino acids; 45160 Da
Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for ZCCHC18: NX_P0CG32

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P0CG32

  • ZCCHC18 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_001137450.1  
    ENSEMBL proteins: 
     ENSP00000473824  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZCCHC: Zinc fingers, CCHC domain containing
    PNMA: Paraneoplastic Ma antigens

    1 InterPro protein domain:
     IPR001878 Znf_CCHC

    Graphical View of Domain Structure for InterPro Entry P0CG32

    ProtoNet protein and cluster: P0CG32

    UniProtKB/Swiss-Prot: ZCC18_HUMAN, P0CG32
    Similarity: Belongs to the ZCCHC12 family
    Similarity: Contains 1 CCHC-type zinc finger


    ZCCHC18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0008270zinc ion binding IEA--
         
    ZCCHC18 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZCCHC18

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
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    Search CenterWatch for drugs/clinical trials and news about ZCCHC18 / ZCC18

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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    About This Section

    REFSEQ mRNAs for ZCCHC18 gene: 
    NM_001143978.2  

    Unigene Cluster for ZCCHC18:

    Zinc finger, CCHC domain containing 18
    Hs.648338  [show with all ESTs]
    Unigene Representative Sequence: NM_001143978
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000423478 ENST00000422784 ENST00000605784 ENST00000603049 ENST00000537356(uc011msg.2 uc011msh.2)

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    Additional mRNA sequence: 

    AF086548.1 NR_026694.1 

    4 DOTS entries:

    DT.306706  DT.97835270  DT.91845332  DT.121303046 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZCCHC18 expression in normal human tissues (normalized intensities)      ZCCHC18 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTCTATTTC
    ZCCHC18 Expression
    About this image


    ZCCHC18 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Endothelial Cells Blood Brain Barrier
             ganglion/cranial/facial VII   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 4 entries
             autonomic/sympathetic/ganglion   
     
     Pancreas (Endocrine System)    fully expand to see all 4 entries
             Endocrine Progenitor Cells Ventral Pancreatic Bud
     
     Blood Brain Barrier (Nervous System)
             Endothelial Cells Blood Brain Barrier
     
     Nose (Sensory Organs)
             sensory organ/nose/nasal cavity   

    Genevestigator expression for ZCCHC18

    SOURCE GeneReport for Unigene cluster: Hs.648338
        SABiosciences Custom PCR Arrays for ZCCHC18
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZCCHC18 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zcchc181 , 5 zinc finger, CCHC domain containing 181, 5 78.18(n)1
    68.54(a)1
      X (59.10 cM)5
    669951  NM_025893.21  NP_080169.21 
     1369931555 


    ENSEMBL Gene Tree for ZCCHC18 (if available)
    TreeFam Gene Tree for ZCCHC18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZCCHC18 gene
    PNMA6A2  PNMA52  PNMA12  PNMA6D2  PNMA22  PNMAL22  PNMA6C2  MOAP12  
    PNMA32  ZCCHC122  PNMAL12  PNMA6B2  
    3 SIMAP similar genes for ZCCHC18 using alignment to 1 protein entry:     ZCC18_HUMAN:
    ZCCHC12    PNMA2    PNMA1

    ZCCHC18 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    2 SNPs in ZCCHC18 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs102181831,2
    C--92982767(+) GATGGA/GGGAGC 2 -- us2k13Minor allele frequency- G:0.00NA 4
    rs2020964511,2
    ----92982760(+) GTCAC-/GGGA  
     TGGGGGA
    GCAGA
    2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZCCHC18 (103356822 - 103360533 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ZCCHC18:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv519626CNV Gain19592680
    nsv469772CNV Complex16826518
    dgv2459e1CNV Complex17122850
    nsv7453OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZCCHC18 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZCCHC18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    2. Identification of proteins that interact with murine c ytomegalovirus early protein M112-113 in brain. (PubMed id 22340173)1 Wang H....Fang F. (2011)
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 644353 HGNC: 32459 Ensembl:ENSG00000166707 euGenes: HUgn644353 ECgene: ZCCHC18
    H-InvDB: ZCCHC18

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZCCHC18 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZCCHC18 gene:
    Search GeneIP for patents involving ZCCHC18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for ZCCHC18
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     Search ThermoFisher Antibodies for ZCCHC18
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZCCHC18
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ZCCHC18
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZCCHC18
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     Search LSBio for Antibodies for ZCCHC18
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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