ZCCHC17 Gene
protein-coding GIFtS: 49
GCID: GC01P031769
|
|
zinc finger, CCHC domain containing 17
| |
Aliases
for ZCCHC17 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger, CCHC Domain Containing 171 2 | | Zinc Finger CCHC Domain-Containing Protein 172 3 | | PS1D1 2 3 | | RP11-266K22.12 | | PNO401 | | Nucleolar Protein 402 | | HSPC2511 2 | | Nucleolar Protein Of 40 KDa2 | | Pnn-Interacting Nucleolar Protein2 3 | | Putative S1 RNA Binding Domain Protein2 | | Putative S1 RNA-Binding Domain Protein2 3 | | PS1D Protein3 |
Export aliases for ZCCHC17 gene to outside databasesPrevious GC identifers: GC01P031439 GC01P031542 GC01P029876 |
Summaries
for ZCCHC17 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for ZCCHC17
|
Genomic Views
for ZCCHC17 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZCCHC17 gene promoter:
AREB6 ISGF-3 RORalpha2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZCCHC17
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZCCHC17 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p35.2 Ensembl cytogenetic band: 1p35.2 HGNC cytogenetic band: 1p35.2ZCCHC17 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P031769: view genomic region
(about GC identifiers)
Start:
|
31,769,842 bp from pter |
End:
|
31,837,783 bp from pter |
Size:
|
67,942 bases |
Orientation:
|
plus strand |
|
Proteins
for ZCCHC17 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NO40_HUMAN, Q9NP64 (See
protein sequence)Recommended Name: Nucleolar protein of 40 kDa Size: 241 amino acids; 27570 Da
Subunit: Interacts with PNN. Associates with the 60S ribosomal subunit (By similarity)
Subcellular location: Nucleus, nucleolus
Sequence caution: Sequence=AAF36171.1; Type=Frameshift; Positions=48;
1 PDB 3D structure from  and Proteopedia  for ZCCHC17:2CQO (3D)
Secondary accessions: D3DPN4 Q6PKH4 Q9NYG4 Q9P0M8Alternative splicing: 2 isoforms: Q9NP64-1 Q9NP64-2 Explore the universe of human proteins at neXtProt for ZCCHC17: NX_Q9NP64
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NP64
ZCCHC17 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057589.2
ENSEMBL proteins: ENSP00000343557 ENSP00000362819 ENSP00000444742 ENSP00000391336
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005730 | nucleolus |
IEA | -- | | GO:0022625 | cytosolic large ribosomal subunit |
IEA | -- |
ZCCHC17 for ontologies About GeneDecksing
ZCCHC17 Antibody Products:
Assay Products for ZCCHC17: |
Protein
Domains /
Families
for ZCCHC17 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZCCHC17 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NP64ProtoNet protein and cluster: Q9NP64 2 Blocks protein families: IPB001878 C2HC-type zinc-finger signature IPB003029 RNA binding S1
UniProtKB/Swiss-Prot: NO40_HUMAN, Q9NP64Similarity: Contains 1 CCHC-type zinc fingerSimilarity: Contains 1 S1 motif domain |
Function
for ZCCHC17 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZCCHC17 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZCCHC17
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: ZCCHC17 (NM_016505) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCCHC17 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZCCHC17 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ZCCHC17:
|
Pathways & Interactions
for ZCCHC17 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZCCHC17
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/10 Interacting proteins for ZCCHC17 (Q9NP642, 3 ENSP000003435574) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
|
Drugs & Compounds
for ZCCHC17 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZCCHC17
Search CenterWatch for drugs/clinical trials and news about ZCCHC17 / NO40
|
Transcripts
for ZCCHC17 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZCCHC17 gene: NM_016505.2 Unigene Cluster for ZCCHC17: Zinc finger, CCHC domain containing 17 Hs.524094 [show with all ESTs]Unigene Representative Sequence: NM_0165056 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000344147(uc001bsp.1 uc001bsq.1 uc010ogf.1 uc009vtu.1)
ENST00000479629 ENST00000373714(uc001bsr.1 uc009vtv.1) ENST00000490049
ENST00000546109 ENST00000422613
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZCCHC17 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZCCHC17
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZCCHC17 (NM_016505) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZCCHC17 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZCCHC17 |
Additional cDNA sequence: AF151077.1 AF151085.1 AF247661.2 AK001929.1 AK022506.1 AK024049.1 AK302248.1 AK302343.1 AK307478.1 BC000685.2 BC007446.2 BC050609.1 24 DOTS entries: DT.215936 DT.445683 DT.95084387 DT.92436552 DT.95084405 DT.99953112 DT.121358375 DT.40229126 DT.100042108 DT.121358294 DT.92436558 DT.100042107 DT.100709578 DT.100742295 DT.102829667 DT.121358312 DT.121358315 DT.121358318 DT.121358336 DT.91792286 DT.95203925 DT.120849243 DT.120849287 DT.75183411 24/323 AceView cDNA sequences (see all 323): AA350561 BM692532 CA431358 AA724342 BX427422 CR602299 BM713919 BM783636 BQ945790 CA420713 AA926709 BM468283 AA485952 BM784283 BM909581 W21409 CA438523 BM781696 BP370817 AI159932 AK022506 AI494244 BQ058013 BM673657
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC17 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 |
|---|
|
| SP1: | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP5: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZCCHC17
|
Expression
for ZCCHC17 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZCCHC17 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGAGAAGTG
About this image
See ZCCHC17 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZCCHC17
SOURCE GeneReport for Unigene cluster: Hs.524094
SABiosciences Custom PCR Arrays for ZCCHC17
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZCCHC17
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCCHC17 |
Orthologs
for ZCCHC17 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZCCHC17 gene from 5/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Zcchc171 , 5 |
zinc finger, CCHC domain containing 171, 5 |
90.46(n)1
95.02(a)1 |
|
4 (63.43 cM)5
6196051 NM_153160.41 NP_694800.11
1303153855 |
chicken
(Gallus gallus) |
Aves |
ZCCHC171 |
zinc finger, CCHC domain containing 17 |
74.03(n)
77.06(a) |
|
404295 NM_206978.1 NP_996861.1 |
lizard
(Anolis carolinensis) |
Reptilia |
ZCCHC176 |
-- |
63(a) |
1 ↔ 1 |
GL343563.1(163944-167048) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.340482 |
Xenopus laevis transcribed sequence with moderate similarity to protein refNP_057589.1 (H.sapiens) hypothetical protein HSPC251 [Homo sapiens] less |
74.82(n) |
|
BJ092643.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc657902 |
hypothetical protein MGC65790 |
76.91(n) |
|
393516 AY253298.1 |
ENSEMBL Gene Tree for ZCCHC17 (if available)
TreeFam Gene Tree for ZCCHC17 (if available) |
Paralogs
for ZCCHC17 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZCCHC17 gene
ZCCHC17 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZCCHC17
PGOHUM00000257115
|
Genomic Variants
for ZCCHC17 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZCCHC17 (31769842 - 31837783 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ZCCHC17
2 CNVs: 2304 3287 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZCCHC17 |
|
Disorders
/ Diseases
for ZCCHC17 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZCCHC17 for disorders About GeneDecksing
2  diseases for ZCCHC17: About MalaCardsmacular degeneration ataxia
Export disorders for ZCCHC17 gene to outside databases
|
Publications
for ZCCHC17 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZCCHC17 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with ZCCHC17) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular characterization of a novel nucleolar protein, pNO40. (PubMed id 12893261)1, 2, 3, 9 Chang W.L....Ouyang P. (2003)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Identification of ribosomal proteins specific to higher eukaryotic organisms. (PubMed id 12202495)1, 3 Gueydan C....Kruys V. (2002)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Comparison of an expanded ataxia interactome with pat ient medical records reveals a relationship between macular degeneration and at axia. (PubMed id 21078624)1 Kahle J.J....Zoghbi H.Y. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
|
External Searches for ZCCHC17 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZCCHC17 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZCCHC17 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZCCHC17 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZCCHC17 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZCCHC17 gene:
Search GeneIP for patents involving ZCCHC17
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZCCHC17 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| |  |  |  |  | | | | |
 |
 |
 |
 | | | ZCCHC17 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCCHC17 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZCCHC17 |
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