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Aliases for ZCCHC14 Gene

Aliases for ZCCHC14 Gene

  • Zinc Finger CCHC-Type Containing 14 2 3
  • Zinc Finger, CCHC Domain Containing 14 3 5
  • BDG-29 3 4
  • KIAA0579 4
  • BDG29 3

External Ids for ZCCHC14 Gene

Previous GeneCards Identifiers for ZCCHC14 Gene

  • GC16M085997
  • GC16M073182

Summaries for ZCCHC14 Gene

GeneCards Summary for ZCCHC14 Gene

ZCCHC14 (Zinc Finger CCHC-Type Containing 14) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and phosphatidylinositol binding. An important paralog of this gene is ZCCHC2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCCHC14 Gene

Genomics for ZCCHC14 Gene

Regulatory Elements for ZCCHC14 Gene

Promoters for ZCCHC14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZCCHC14 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZCCHC14 Gene

Chromosome:
16
Start:
87,406,246 bp from pter
End:
87,492,269 bp from pter
Size:
86,024 bases
Orientation:
Minus strand

Genomic View for ZCCHC14 Gene

Genes around ZCCHC14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZCCHC14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZCCHC14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCCHC14 Gene

Proteins for ZCCHC14 Gene

  • Protein details for ZCCHC14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WYQ9-ZCH14_HUMAN
    Recommended name:
    Zinc finger CCHC domain-containing protein 14
    Protein Accession:
    Q8WYQ9
    Secondary Accessions:
    • D3DUN1
    • O60324
    • Q3MJD8
    • Q9UFP0

    Protein attributes for ZCCHC14 Gene

    Size:
    949 amino acids
    Molecular mass:
    100042 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZCCHC14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZCCHC14 Gene

Proteomics data for ZCCHC14 Gene at MOPED

Post-translational modifications for ZCCHC14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZCCHC14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZCCHC14 Gene

Domains & Families for ZCCHC14 Gene

Protein Domains for ZCCHC14 Gene

Suggested Antigen Peptide Sequences for ZCCHC14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WYQ9

UniProtKB/Swiss-Prot:

ZCH14_HUMAN :
  • Contains 1 CCHC-type zinc finger.
Similarity:
  • Contains 1 CCHC-type zinc finger.
genes like me logo Genes that share domains with ZCCHC14: view

Function for ZCCHC14 Gene

Gene Ontology (GO) - Molecular Function for ZCCHC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IEA --
GO:0035091 phosphatidylinositol binding IEA --
genes like me logo Genes that share ontologies with ZCCHC14: view
genes like me logo Genes that share phenotypes with ZCCHC14: view

Animal Models for ZCCHC14 Gene

MGI Knock Outs for ZCCHC14:

Animal Model Products

  • Taconic Biosciences Mouse Models for ZCCHC14

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZCCHC14 Gene

Localization for ZCCHC14 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZCCHC14 Gene COMPARTMENTS Subcellular localization image for ZCCHC14 gene
Compartment Confidence
cytosol 3
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZCCHC14 Gene

Pathways & Interactions for ZCCHC14 Gene

SuperPathways for ZCCHC14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZCCHC14 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZCCHC14 Gene

Drugs & Compounds for ZCCHC14 Gene

No Compound Related Data Available

Transcripts for ZCCHC14 Gene

Unigene Clusters for ZCCHC14 Gene

Zinc finger, CCHC domain containing 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC14 Gene

No ASD Table

Relevant External Links for ZCCHC14 Gene

GeneLoc Exon Structure for
ZCCHC14
ECgene alternative splicing isoforms for
ZCCHC14

Expression for ZCCHC14 Gene

mRNA expression in normal human tissues for ZCCHC14 Gene

Protein differential expression in normal tissues from HIPED for ZCCHC14 Gene

This gene is overexpressed in Fetal testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZCCHC14 Gene



SOURCE GeneReport for Unigene cluster for ZCCHC14 Gene Hs.156231

genes like me logo Genes that share expression patterns with ZCCHC14: view

Protein tissue co-expression partners for ZCCHC14 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZCCHC14 Gene

Orthologs for ZCCHC14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZCCHC14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZCCHC14 35
  • 85.41 (n)
  • 86.61 (a)
ZCCHC14 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZCCHC14 35
  • 84.93 (n)
  • 84.69 (a)
ZCCHC14 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zcchc14 35
  • 83.91 (n)
  • 85.77 (a)
Zcchc14 16
Zcchc14 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZCCHC14 35
  • 99.48 (n)
  • 99.55 (a)
ZCCHC14 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zcchc14 35
  • 83.51 (n)
  • 84.53 (a)
oppossum
(Monodelphis domestica)
Mammalia ZCCHC14 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZCCHC14 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857578 35
  • 75.51 (n)
  • 76.05 (a)
-- 36
  • 70 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia ZCCHC14 36
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zcchc14 35
  • 54.35 (n)
  • 48.36 (a)
zcchc14 36
  • 34 (a)
OneToOne
Species with no ortholog for ZCCHC14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZCCHC14 Gene

ENSEMBL:
Gene Tree for ZCCHC14 (if available)
TreeFam:
Gene Tree for ZCCHC14 (if available)

Paralogs for ZCCHC14 Gene

Paralogs for ZCCHC14 Gene

genes like me logo Genes that share paralogs with ZCCHC14: view

Variants for ZCCHC14 Gene

Sequence variations from dbSNP and Humsavar for ZCCHC14 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3748400 - 87,412,233(+) GCCCA(C/T)TGGCA nc-transcript-variant, reference, missense
VAR_036492 A breast cancer sample
rs11648852 - 87,460,131(+) AGTGA(C/T)CTGAG nc-transcript-variant, reference, missense
rs13338940 - 87,417,701(+) GGGCT(C/G)CGCTC nc-transcript-variant, reference, missense
rs1131346 -- 87,407,888(-) GGCCT(C/T)TTTTC nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZCCHC14 Gene

Variant ID Type Subtype PubMed ID
nsv907153 CNV Loss 21882294
nsv907156 CNV Loss 21882294
nsv833320 CNV Gain 17160897
nsv428330 CNV Gain 18775914
dgv499n67 CNV Gain 20364138
dgv2950n71 CNV Loss 21882294
nsv827804 CNV Gain 20364138
nsv907160 CNV Loss 21882294
nsv907161 CNV Loss 21882294
esv33545 CNV Gain 17666407
nsv833321 CNV Gain+Loss 17160897
nsv907162 CNV Loss 21882294
nsv525605 CNV Gain 19592680
dgv500n67 CNV Gain 20364138
esv24735 CNV Gain 19812545
esv1007865 CNV Loss 20482838
dgv501n67 CNV Gain 20364138
nsv827811 CNV Gain 20364138

Variation tolerance for ZCCHC14 Gene

Residual Variation Intolerance Score: 7.85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.90; 96.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZCCHC14 Gene

HapMap Linkage Disequilibrium report
ZCCHC14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZCCHC14 Gene

Disorders for ZCCHC14 Gene

Relevant External Links for ZCCHC14

Genetic Association Database (GAD)
ZCCHC14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZCCHC14

No disorders were found for ZCCHC14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZCCHC14 Gene

Publications for ZCCHC14 Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A mega-analysis of genome-wide association studies for major depressive disorder. (PMID: 22472876) . … Sullivan P.F. (Mol. Psychiatry 2013) 3
  4. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for ZCCHC14 Gene

Sources for ZCCHC14 Gene

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