ZCCHC14 Gene
protein-coding GIFtS: 45
GCID: GC16M087439
|
|
zinc finger, CCHC domain containing 14
| |
Aliases
for ZCCHC14 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger, CCHC Domain Containing 141 2 | | BDG291 2 | | BDG-292 3 | | MGC141391 | | Zinc Finger CCHC Domain-Containing Protein 142 | | KIAA05793 |
Export aliases for ZCCHC14 gene to outside databasesPrevious GC identifers: GC16M085997 GC16M073182 |
Summaries
for ZCCHC14 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ZCCHC14 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZCCHC14 gene promoter:
AhR Sp1 NRSF form 1 NRSF form 2 C/EBPalpha Arnt NRF-2 HOXA5 NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZCCHC14
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZCCHC14 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q24.2 Ensembl cytogenetic band: 16q24.2 HGNC cytogenetic band: 16q24.2ZCCHC14 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M087439: view genomic region
(about GC identifiers)
Start:
|
87,439,852 bp from pter |
End:
|
87,525,651 bp from pter |
Size:
|
85,800 bases |
Orientation:
|
minus strand |
|
Proteins
for ZCCHC14 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZCH14_HUMAN, Q8WYQ9 (See
protein sequence)Recommended Name: Zinc finger CCHC domain-containing protein 14 Size: 949 amino acids; 100042 Da
Secondary accessions: D3DUN1 O60324 Q3MJD8 Q9UFP0Alternative splicing: 2 isoforms: Q8WYQ9-1 Q8WYQ9-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZCCHC14: NX_Q8WYQ9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WYQ9
ZCCHC14 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055959.1
ENSEMBL proteins: ENSP00000268616 ENSP00000455431 ENSP00000456499
Human Recombinant Protein Products:
ZCCHC14 Antibody Products:
Assay Products for ZCCHC14: |
Protein
Domains /
Families
for ZCCHC14 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZCCHC14 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WYQ9ProtoNet protein and cluster: Q8WYQ9 2 Blocks protein families: IPB001660 Sterile alpha motif SAM IPB001878 C2HC-type zinc-finger signature
UniProtKB/Swiss-Prot: ZCH14_HUMAN, Q8WYQ9Similarity: Contains 1 CCHC-type zinc finger |
Function
for ZCCHC14 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZCCHC14 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZCCHC14
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZCCHC14 (NM_015144) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZCCHC14 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZCCHC14 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCCHC14 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- | | GO:0035091 | phosphatidylinositol binding |
IEA | -- |
ZCCHC14 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZCCHC14:
|
Pathways & Interactions
for ZCCHC14 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZCCHC14
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for ZCCHC14 (Q8WYQ93 ENSP000002686164) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007154 | cell communication |
IEA | -- |
ZCCHC14 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZCCHC14 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZCCHC14
Search CenterWatch for drugs/clinical trials and news about ZCCHC14 / ZCH14
|
Transcripts
for ZCCHC14 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZCCHC14 gene: NM_015144.2 Unigene Cluster for ZCCHC14: Zinc finger, CCHC domain containing 14 Hs.156231 [show with all ESTs]Unigene Representative Sequence: NM_0151444 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000268616(uc002fjz.1) ENST00000568020(uc002fka.1) ENST00000561928(uc002fkb.3)
ENST00000565193
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZCCHC14 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZCCHC14
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZCCHC14 (NM_015144) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZCCHC14 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZCCHC14 |
Additional cDNA sequence: AB011151.2 AK289682.1 AL117532.1 BC028304.1 BC038944.1 BC101478.1 6 DOTS entries: DT.446815 DT.100777494 DT.86852316 DT.95161966 DT.75116692 DT.91664551 24/205 AceView cDNA sequences (see all 205): BC038944 CA393588 H71564 BE048540 AA385091 AI989440 CA393596 BG114112 NM_015144 AI174966 AB030243 BU628796 T96988 AA670389 BE703590 T33439 BC028304 BC007926 BM669533 AA977033 AI803982 AW243209 AL117532 CA424914
GeneLoc Exon Structure
|
Expression
for ZCCHC14 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZCCHC14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAACTTTATA
About this image
See ZCCHC14 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZCCHC14
SOURCE GeneReport for Unigene cluster: Hs.156231
SABiosciences Custom PCR Arrays for ZCCHC14
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZCCHC14
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZCCHC14 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZCCHC14 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZCCHC14 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCCHC14 |
Orthologs
for ZCCHC14 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZCCHC14 gene from 5/15 species (see all 15) About this table
ENSEMBL Gene Tree for ZCCHC14 (if available)
TreeFam Gene Tree for ZCCHC14 (if available) |
Paralogs
for ZCCHC14 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZCCHC14 gene
- ZCCHC22
ZCCHC14 for paralogs About GeneDecksing
|
Genomic Variants
for ZCCHC14 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZCCHC14 (87439852 - 87525651 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for ZCCHC14
4 CNVs: 4970 72665 4971 72664
2 Indels: 40157 11121 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZCCHC14 |
|
Disorders
/ Diseases
for ZCCHC14 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZCCHC14 for disorders About GeneDecksing
3  diseases for ZCCHC14: About MalaCardsvesicoureteral reflux lymphedema microcephaly
Export disorders for ZCCHC14 gene to outside databases
|
Publications
for ZCCHC14 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZCCHC14 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with ZCCHC14) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2, 3 Nagase T....Ohara O. (1998)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
- A mega-analysis of genome-wide association studies for major depressive disorder. (PubMed id 22472876)1 (2012)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
|
External Searches for ZCCHC14 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZCCHC14 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZCCHC14 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ZCCHC14 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZCCHC14 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZCCHC14 gene:
Search GeneIP for patents involving ZCCHC14
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZCCHC14 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZCCHC14 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZCCHC14 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZCCHC14 | | | OriGene Protein Over-expression Lysate for ZCCHC14 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZCCHC14 | | OriGene 3'-UTR Clone for ZCCHC14 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZCCHC14 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZCCHC14 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZCCHC14 | | OriGene Custom Protein Services for ZCCHC14 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZCCHC14 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZCCHC14 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZCCHC14 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZCCHC14 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZCCHC14 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZCCHC14 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ZCCHC14 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | ZCCHC14 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCCHC14 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZCCHC14 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZCCHC14 |
|
|
|
|
