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Aliases for ZCCHC14 Gene

Aliases for ZCCHC14 Gene

  • Zinc Finger CCHC-Type Containing 14 2 3 5
  • BDG-29 3 4
  • Zinc Finger CCHC Domain-Containing Protein 14 3
  • Zinc Finger, CCHC Domain Containing 14 3
  • KIAA0579 4
  • BDG29 3

External Ids for ZCCHC14 Gene

Previous GeneCards Identifiers for ZCCHC14 Gene

  • GC16M085997
  • GC16M073182

Summaries for ZCCHC14 Gene

GeneCards Summary for ZCCHC14 Gene

ZCCHC14 (Zinc Finger CCHC-Type Containing 14) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and phosphatidylinositol binding. An important paralog of this gene is ZCCHC2.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCCHC14 Gene

Genomics for ZCCHC14 Gene

Regulatory Elements for ZCCHC14 Gene

Enhancers for ZCCHC14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G088298 1.3 ENCODE dbSUPER 18.2 -806.8 -806752 1.8 HDGF PKNOX1 CREB3L1 ARNT SIN3A YBX1 ZNF766 ZNF207 FOS KLF13 ENSG00000259877 ZCCHC14 APRT ZNF778 ENSG00000268218 ENSG00000260121 GC16P088248 ZFPM1
GH16G087483 1.4 ENCODE dbSUPER 16.5 +3.5 3517 10.3 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC ZNF610 ZCCHC14 LOC101928659 ENSG00000276337
GH16G087468 0.9 dbSUPER 23.2 +23.4 23441 0.9 NFRKB ZSCAN4 NFXL1 BMI1 YBX1 RAD21 ZNF23 ZNF354C ZNF207 BCLAF1 ZCCHC14 KLHDC4 NR3C1P1 ENSG00000276337
GH16G088329 2 FANTOM5 Ensembl ENCODE dbSUPER 9.8 -840.6 -840588 6.0 HDGF PKNOX1 ARNT SIN3A YBX1 ZBTB7B ZNF766 ZNF207 FOS KLF13 ENSG00000259877 ENSG00000268218 LOC100289580 LOC339059 ENSG00000260279 LOC100129215 CTU2 LINC00304 ENSG00000260121 ZCCHC14
GH16G086950 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +539.9 539938 3.1 HDGF PKNOX1 ATF1 YBX1 ZBTB7B TCF12 GATA2 ZNF207 ZNF143 FOS LOC101928659 ZCCHC14 LINC02181 FOXC2 FOXL1 GC16M086906 LOC105371393
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZCCHC14 on UCSC Golden Path with GeneCards custom track

Promoters for ZCCHC14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ZCCHC14 Gene

87,406,246 bp from pter
87,492,269 bp from pter
86,024 bases
Minus strand

Genomic View for ZCCHC14 Gene

Genes around ZCCHC14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZCCHC14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZCCHC14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCCHC14 Gene

Proteins for ZCCHC14 Gene

  • Protein details for ZCCHC14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger CCHC domain-containing protein 14
    Protein Accession:
    Secondary Accessions:
    • D3DUN1
    • O60324
    • Q3MJD8
    • Q9UFP0

    Protein attributes for ZCCHC14 Gene

    949 amino acids
    Molecular mass:
    100042 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZCCHC14 Gene


neXtProt entry for ZCCHC14 Gene

Post-translational modifications for ZCCHC14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZCCHC14 Gene

No data available for DME Specific Peptides for ZCCHC14 Gene

Domains & Families for ZCCHC14 Gene

Protein Domains for ZCCHC14 Gene

Suggested Antigen Peptide Sequences for ZCCHC14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZCCHC14: view

No data available for UniProtKB/Swiss-Prot for ZCCHC14 Gene

Function for ZCCHC14 Gene

Gene Ontology (GO) - Molecular Function for ZCCHC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0035091 phosphatidylinositol binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZCCHC14: view
genes like me logo Genes that share phenotypes with ZCCHC14: view

Animal Models for ZCCHC14 Gene

MGI Knock Outs for ZCCHC14:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZCCHC14 Gene

Localization for ZCCHC14 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZCCHC14 gene
Compartment Confidence
nucleus 3
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZCCHC14 Gene

Pathways & Interactions for ZCCHC14 Gene

SuperPathways for ZCCHC14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZCCHC14 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZCCHC14 Gene

Drugs & Compounds for ZCCHC14 Gene

No Compound Related Data Available

Transcripts for ZCCHC14 Gene

Unigene Clusters for ZCCHC14 Gene

Zinc finger, CCHC domain containing 14:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC14 Gene

No ASD Table

Relevant External Links for ZCCHC14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZCCHC14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZCCHC14 Gene

Protein differential expression in normal tissues from HIPED for ZCCHC14 Gene

This gene is overexpressed in Fetal testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZCCHC14 Gene

Protein tissue co-expression partners for ZCCHC14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZCCHC14 Gene:


SOURCE GeneReport for Unigene cluster for ZCCHC14 Gene:


Evidence on tissue expression from TISSUES for ZCCHC14 Gene

  • Nervous system(4.6)
  • Intestine(2.9)
genes like me logo Genes that share expression patterns with ZCCHC14: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZCCHC14 Gene

Orthologs for ZCCHC14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZCCHC14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZCCHC14 34 35
  • 99.48 (n)
(Bos Taurus)
Mammalia ZCCHC14 34 35
  • 85.41 (n)
(Canis familiaris)
Mammalia ZCCHC14 34 35
  • 84.93 (n)
(Mus musculus)
Mammalia Zcchc14 34 16 35
  • 83.91 (n)
(Rattus norvegicus)
Mammalia Zcchc14 34
  • 83.51 (n)
(Monodelphis domestica)
Mammalia ZCCHC14 35
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia ZCCHC14 35
  • 80 (a)
(Gallus gallus)
Aves LOC100857578 34
  • 75.51 (n)
-- 35
  • 70 (a)
-- 35
  • 70 (a)
(Anolis carolinensis)
Reptilia ZCCHC14 35
  • 69 (a)
(Danio rerio)
Actinopterygii zcchc14 34 35
  • 54.35 (n)
Species where no ortholog for ZCCHC14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZCCHC14 Gene

Gene Tree for ZCCHC14 (if available)
Gene Tree for ZCCHC14 (if available)

Paralogs for ZCCHC14 Gene

Paralogs for ZCCHC14 Gene

genes like me logo Genes that share paralogs with ZCCHC14: view

Variants for ZCCHC14 Gene

Sequence variations from dbSNP and Humsavar for ZCCHC14 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_036492 A breast cancer sample
rs1000043714 -- 87,443,383(+) TGTCA(A/G)GTGAG intron-variant
rs1000072339 -- 87,425,950(+) CAGAC(A/C)ATCTG intron-variant
rs1000093528 -- 87,475,094(+) AAAGA(C/G)GAAAG intron-variant
rs1000108352 -- 87,487,687(+) CCTAT(A/T)AACCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZCCHC14 Gene

Variant ID Type Subtype PubMed ID
dgv499n67 CNV gain 20364138
dgv500n67 CNV gain 20364138
dgv501n67 CNV gain 20364138
esv1007865 CNV loss 20482838
esv24735 CNV gain 19812545
esv33545 CNV gain 17666407
esv3553846 CNV deletion 23714750
esv3639515 CNV loss 21293372
nsv428330 CNV gain 18775914
nsv525605 CNV gain 19592680
nsv827804 CNV gain 20364138
nsv827811 CNV gain 20364138
nsv833320 CNV gain 17160897
nsv833321 CNV gain+loss 17160897
nsv952064 CNV deletion 24416366

Variation tolerance for ZCCHC14 Gene

Residual Variation Intolerance Score: 7.85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.90; 96.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZCCHC14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZCCHC14 Gene

Disorders for ZCCHC14 Gene

Relevant External Links for ZCCHC14

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZCCHC14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZCCHC14 Gene

Publications for ZCCHC14 Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
  2. A mega-analysis of genome-wide association studies for major depressive disorder. (PMID: 22472876) . … Sullivan P.F. (Mol. Psychiatry 2013) 3 46 64
  3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for ZCCHC14 Gene

Sources for ZCCHC14 Gene

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