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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZCCHC14 Gene

protein-coding   GIFtS: 47
GCID: GC16M087439

Zinc Finger, CCHC Domain Containing 14
  4 related diseases
at
MalaCards
 

Aliases
for ZCCHC14 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Zinc Finger, CCHC Domain Containing 141 2
BDG-292 3
BDG292
Zinc Finger CCHC Domain-Containing Protein 142
KIAA05793

External Ids:    HGNC: 241341   Entrez Gene: 231742   Ensembl: ENSG000001409487   UniProtKB: Q8WYQ93   

Export aliases for ZCCHC14 gene to outside databases

Previous GC identifers: GC16M085997 GC16M073182


Summaries
for ZCCHC14 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
GeneCards Summary for ZCCHC14 Gene: 
ZCCHC14 (zinc finger, CCHC domain containing 14) is a protein-coding gene. Diseases associated with ZCCHC14 include vesicoureteral reflux, and lymphedema. GO annotations related to this gene include phosphatidylinositol binding and nucleic acid binding. An important paralog of this gene is ZCCHC2.


Genomic Views
for ZCCHC14 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZCCHC14 gene promoter:
         AhR   Sp1   NRSF form 1   NRSF form 2   C/EBPalpha   Arnt   NRF-2   HOXA5   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZCCHC14 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZCCHC14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZCCHC14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.2   Ensembl cytogenetic band:  16q24.2   HGNC cytogenetic band: 16q24.2

ZCCHC14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZCCHC14 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M087439:  view genomic region     (about GC identifiers)

Start:
 87,439,852 bp from pter      End:
 87,525,651 bp from pter
Size:
 85,800 bases      Orientation:
 minus strand

Proteins
for ZCCHC14 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: ZCH14_HUMAN, Q8WYQ9 (See protein sequence)
Recommended Name: Zinc finger CCHC domain-containing protein 14  
Size: 949 amino acids; 100042 Da
Secondary accessions: D3DUN1 O60324 Q3MJD8 Q9UFP0
Alternative splicing: 2 isoforms:  Q8WYQ9-1   Q8WYQ9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZCCHC14: NX_Q8WYQ9

Explore proteomics data for ZCCHC14 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WYQ9

    • ZCCHC14 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZCCHC14 Protein Expression
    REFSEQ proteins: NP_055959.1  
    ENSEMBL proteins: 
     ENSP00000268616   ENSP00000455431   ENSP00000456499  

    Human Recombinant Protein Products for ZCCHC14: 
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    Novus Biologicals ZCCHC14 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for ZCCHC14 


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    Abcam antibodies for ZCCHC14
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    LSBio Antibodies in human, mouse, rat for ZCCHC14 

    Assay Products for ZCCHC14: 
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    Cloud-Clone Corp. ELISAs for ZCCHC14 
    Cloud-Clone Corp. CLIAs for ZCCHC14

    Protein Domains /
    Families
    for ZCCHC14 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    ZCCHC: Zinc fingers, CCHC domain containing
    SAMD: Sterile alpha motif (SAM) domain containing

    4 InterPro protein domains:
     IPR013761 SAM/pointed
     IPR021129 SAM_type1
     IPR001683 Phox
     IPR001878 Znf_CCHC

    Graphical View of Domain Structure for InterPro Entry Q8WYQ9

    ProtoNet protein and cluster: Q8WYQ9

    2 Blocks protein domains:
    IPB001660 Sterile alpha motif SAM
    IPB001878 C2HC-type zinc-finger signature


    UniProtKB/Swiss-Prot: ZCH14_HUMAN, Q8WYQ9
    Similarity: Contains 1 CCHC-type zinc finger


    ZCCHC14 for domains           About GeneDecksing


    Function
    for ZCCHC14 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0035091phosphatidylinositol binding IEA--
         
    ZCCHC14 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZCCHC14:
     Decreased viability with pacli 

         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Zcchc14):
     growth/size  skeleton 

    ZCCHC14 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZCCHC14 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZCCHC14

    miRNA
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    Gene Editing
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    Clone
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    OriGene clones in human, mouse for ZCCHC14 (see all 7)
    OriGene ORF clones in mouse, rat for ZCCHC14
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCCHC14


    Pathways & Interactions
    for ZCCHC14 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZCCHC14

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for ZCCHC14 (Q8WYQ93 ENSP000002686164) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFICP086513, ENSP000003968434I2D: score=2 STRING: ENSP00000396843
    NFIXENSP000003532194STRING: ENSP00000353219
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    SMAD3ENSP000003329734STRING: ENSP00000332973
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007154cell communication IEA--

    ZCCHC14 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZCCHC14 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZCCHC14 (ZCH14)

    Search CenterWatch for drugs/clinical trials and news about ZCCHC14 / ZCH14

    Transcripts
    for ZCCHC14 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ZCCHC14 gene: 
    NM_015144.2  

    Unigene Cluster for ZCCHC14:

    Zinc finger, CCHC domain containing 14
    Hs.156231  [show with all ESTs]
    Unigene Representative Sequence: NM_015144
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000268616(uc002fjz.1) ENST00000568020(uc002fka.1) ENST00000561928(uc002fkb.3)
    ENST00000565193
    miRNA
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    8/140 QIAGEN miScript miRNA Assays for microRNAs that regulate ZCCHC14 (see all 140):
    hsa-miR-3938 hsa-miR-605 hsa-miR-138-2* hsa-miR-200b hsa-miR-130b hsa-miR-4255 hsa-miR-548y hsa-miR-4277
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZCCHC14
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZCCHC14

    Additional mRNA sequence: 

    AB011151.2 AK289682.1 AL117532.1 BC028304.1 BC038944.1 BC101478.1 

    6 DOTS entries:

    DT.446815  DT.100777494  DT.86852316  DT.95161966  DT.75116692  DT.91664551 

    24/205 AceView cDNA sequences (see all 205):

    CA393588 BE048540 BC028304 AA385091 BG114112 BU628796 AI174966 BE222936 
    AA977033 AB030243 AA670389 H71564 AA910738 CA444765 AL120272 AL044044 
    AI969298 CA307248 AI803982 AI433890 BC038944 CA425678 AA429529 AI989440 

    GeneLoc Exon Structure


    Expression
    for ZCCHC14 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZCCHC14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAACTTTATA
    ZCCHC14 Expression
    About this image


    See ZCCHC14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZCCHC14

    SOURCE GeneReport for Unigene cluster: Hs.156231
        SABiosciences Custom PCR Arrays for ZCCHC14
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    In Situ
    Assay Products:     
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    Orthologs
    for ZCCHC14 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ZCCHC14 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Zcchc141 , 5 zinc finger, CCHC domain containing 141, 5 84.33(n)1
    86.3(a)1    		   8 (70.67 cM)5
    1426821  NM_080855.21  NP_543131.11 
     1215987035 
    chicken
    (Gallus gallus)    		 Aves LOC1008575781 zinc finger CCHC domain-containing protein 14-like 77.72(n)
    79.7(a)    		   100857578  XM_003643184.1  XP_003643232.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ZCCHC146
    		 Uncharacterized protein
    		 69(a)
    		 1 ↔ 1
    		 GL343957.1(88040-104843)
    zebrafish
    (Danio rerio)    		 Actinopterygii zcchc146
    		 zinc finger, CCHC domain containing 14
    		 33(a)
    		 1 ↔ 1
    		 25(13323351-13379067)


    ENSEMBL Gene Tree for ZCCHC14 (if available)
    TreeFam Gene Tree for ZCCHC14 (if available)

    Paralogs
    for ZCCHC14 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZCCHC14 gene
    ZCCHC22  

    ZCCHC14 for paralogs           About GeneDecksing



    Genomic Variants
    for ZCCHC14 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2364 SNPs in ZCCHC14 are shown (see all 2364)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    VAR_0364924
    		A breast cancer sample4--see VAR_0364922 L V mis40--------
    rs1997636701,2
    		C--87439368(+) GGACAA/CTTAAA 1 -- int10--------
    rs1881868831,2
    		--87439447(+) GAGGCA/GGGAGG 1 -- int10--------
    rs1817779921,2
    		--87439538(+) CGGGCA/GTGGTG 1 -- int10--------
    rs133395601,2
    		C--87439569(+) ctactC/Tgggag 1 -- int10--------
    rs1873063141,2
    		--87439615(+) GGCGTC/GAGCTG 1 -- int10--------
    rs80628131,2
    		C--87439626(+) agatcA/Gtgtca 1 -- int10--------
    rs794565461,2
    		C,F--87439634(+) TCACCA/GCATTC 1 -- int12Minor allele frequency- G:0.03WA NA 238
    rs2006690111,2
    		C--87439674(-) TTTTTC/TTNNNN 1 -- int10--------
    rs1464509591,2
    		C--87439753(+) AAATGC/TGAGAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZCCHC14 (87439852 - 87525651 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/18 variations for ZCCHC14 (see all 18):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv2950n71CNV Loss21882294
    nsv907162CNV Loss21882294
    nsv907160CNV Loss21882294
    esv1007865CNV Loss20482838
    nsv907153CNV Loss21882294
    nsv907161CNV Loss21882294
    nsv907156CNV Loss21882294
    esv33545CNV Gain17666407
    dgv501n67CNV Gain20364138
    dgv499n67CNV Gain20364138

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for ZCCHC14 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ZCCHC14 for disorders           About GeneDecksing

    4 diseases for ZCCHC14:    About MalaCards
    vesicoureteral reflux    lymphedema    microcephaly    major depressive disorder

    Genetic Association Database (GAD): ZCCHC14

    Export disorders for ZCCHC14 gene to outside databases

    Publications
    for ZCCHC14 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZCCHC14 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with ZCCHC14)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2, 3 Nagase T....Ohara O. (1998)
    2. A mega-analysis of genome-wide association studies for major depressive disorder. (PubMed id 22472876)1, 4 (2012)
    3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    4. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)
    5. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    6. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    8. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)

    External Searches for ZCCHC14 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ZCCHC14 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23174 HGNC: 24134 AceView: ZCCHC14 Ensembl:ENSG00000140948 euGenes: HUgn23174
    ECgene: ZCCHC14 H-InvDB: ZCCHC14

    Other Databases showing ZCCHC14 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0579

    Specialized Databases showing ZCCHC14 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZCCHC14 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ZCCHC14 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ZCCHC14 gene:
    Search GeneIP for patents involving ZCCHC14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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