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Aliases for ZCCHC13 Gene

Aliases for ZCCHC13 Gene

  • Zinc Finger CCHC-Type Containing 13 2 3 5
  • Zinc Finger CCHC Domain-Containing Protein 13 3
  • Zinc Finger, CCHC Domain Containing 13 3
  • CNBP2 3
  • ZNF9L 3

External Ids for ZCCHC13 Gene

Previous GeneCards Identifiers for ZCCHC13 Gene

  • GC0XP073307
  • GC0XP073440
  • GC0XP073524
  • GC0XP067159

Summaries for ZCCHC13 Gene

Entrez Gene Summary for ZCCHC13 Gene

  • This gene appears to represent an intronless retrocopy of a related multi-exon gene located on chromosome 3. However, the CDS of this intronless gene remains relatively intact, it is conserved in other mammalian species, it is known to be transcribed, and it is therefore thought to encode a functional protein. The encoded protein contains six CCHC-type zinc fingers, and is thus thought to function as a transcription factor. [provided by RefSeq, May 2010]

GeneCards Summary for ZCCHC13 Gene

ZCCHC13 (Zinc Finger CCHC-Type Containing 13) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is CNBP.

Additional gene information for ZCCHC13 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCCHC13 Gene

Genomics for ZCCHC13 Gene

GeneHancer (GH) Regulatory Elements for ZCCHC13 Gene

Promoters and enhancers for ZCCHC13 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI074304 Promoter 0.5 EPDnew 550.8 0.0 -19 0.1 ZCCHC13 FTX
GH0XI074342 Enhancer 1.1 Ensembl ENCODE 12.9 +39.4 39440 1.9 FEZF1 ZNF2 ETS1 ZNF766 ZNF143 KLF7 FOS RUNX3 KLF13 DEK ENSG00000226515 FTX ZCCHC13 ENSG00000271533 LOC727681
GH0XI074240 Enhancer 1 Ensembl ENCODE 12.3 -61.8 -61764 3 ELF3 FOXA2 THRB RARA CREM MIXL1 RXRA PPARG NFIL3 ETV4 RN7SL648P GC0XP074243 MIR421 MIR374B FTX ZCCHC13 MIR545 MIR374A JPX GC0XP074233
GH0XI074324 Enhancer 0.6 ENCODE 13.6 +21.7 21699 2.2 CTCF MXI1 USF1 RFX1 SIN3A E4F1 RAD21 MITF SP1 VEZF1 ZCCHC13 FTX JPX NEXMIF ENSG00000226515
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZCCHC13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZCCHC13 gene promoter:

Genomic Locations for ZCCHC13 Gene

Genomic Locations for ZCCHC13 Gene
chrX:74,304,190-74,305,034
(GRCh38/hg38)
Size:
845 bases
Orientation:
Plus strand
chrX:73,524,025-73,524,869
(GRCh37/hg19)

Genomic View for ZCCHC13 Gene

Genes around ZCCHC13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZCCHC13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZCCHC13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCCHC13 Gene

Proteins for ZCCHC13 Gene

  • Protein details for ZCCHC13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WW36-ZCH13_HUMAN
    Recommended name:
    Zinc finger CCHC domain-containing protein 13
    Protein Accession:
    Q8WW36

    Protein attributes for ZCCHC13 Gene

    Size:
    166 amino acids
    Molecular mass:
    18005 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZCCHC13 Gene

Post-translational modifications for ZCCHC13 Gene

No Post-translational modifications

Other Protein References for ZCCHC13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZCCHC13 Gene

Domains & Families for ZCCHC13 Gene

Gene Families for ZCCHC13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZCCHC13 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZCCHC13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZCCHC13: view

No data available for UniProtKB/Swiss-Prot for ZCCHC13 Gene

Function for ZCCHC13 Gene

Gene Ontology (GO) - Molecular Function for ZCCHC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZCCHC13: view
genes like me logo Genes that share phenotypes with ZCCHC13: view

miRNA for ZCCHC13 Gene

miRTarBase miRNAs that target ZCCHC13

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZCCHC13 Gene

Localization for ZCCHC13 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZCCHC13 gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ZCCHC13 Gene

Pathways & Interactions for ZCCHC13 Gene

SuperPathways for ZCCHC13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZCCHC13 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZCCHC13 Gene

Drugs & Compounds for ZCCHC13 Gene

No Compound Related Data Available

Transcripts for ZCCHC13 Gene

mRNA/cDNA for ZCCHC13 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZCCHC13 Gene

Zinc finger, CCHC domain containing 13:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC13 Gene

No ASD Table

Relevant External Links for ZCCHC13 Gene

GeneLoc Exon Structure for
ZCCHC13
ECgene alternative splicing isoforms for
ZCCHC13

Expression for ZCCHC13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZCCHC13 Gene

mRNA differential expression in normal tissues according to GTEx for ZCCHC13 Gene

This gene is overexpressed in Testis (x52.9).

Protein differential expression in normal tissues from HIPED for ZCCHC13 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZCCHC13 Gene



Protein tissue co-expression partners for ZCCHC13 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZCCHC13 Gene:

ZCCHC13

SOURCE GeneReport for Unigene cluster for ZCCHC13 Gene:

Hs.157231
genes like me logo Genes that share expression patterns with ZCCHC13: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZCCHC13 Gene

Orthologs for ZCCHC13 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZCCHC13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZCCHC13 33
  • 99.11 (n)
dog
(Canis familiaris)
Mammalia ZCCHC13 34
  • 77 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZCCHC13 34
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 59 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zcchc13 34
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 48 (a)
ManyToMany
chicken
(Gallus gallus)
Aves CNBP 34
  • 58 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii cnbpb 34
  • 53 (a)
ManyToMany
cnbpa 34
  • 52 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3800 34
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K08D12.3 34
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GIS2 34
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10180 34
  • 24 (a)
OneToMany
Species where no ortholog for ZCCHC13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZCCHC13 Gene

ENSEMBL:
Gene Tree for ZCCHC13 (if available)
TreeFam:
Gene Tree for ZCCHC13 (if available)

Paralogs for ZCCHC13 Gene

Paralogs for ZCCHC13 Gene

(2) SIMAP similar genes for ZCCHC13 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZCCHC13: view

Variants for ZCCHC13 Gene

Sequence variations from dbSNP and Humsavar for ZCCHC13 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1001564499 -- 74,304,357(+) G/C coding_sequence_variant, missense_variant
rs1002266041 -- 74,304,903(+) T/C 3_prime_UTR_variant
rs1002298592 -- 74,305,465(+) G/A downstream_transcript_variant
rs1004406889 -- 74,303,979(+) A/C upstream_transcript_variant
rs1007231326 -- 74,303,420(+) G/C upstream_transcript_variant

Variation tolerance for ZCCHC13 Gene

Residual Variation Intolerance Score: 73.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.83; 47.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZCCHC13 Gene

Human Gene Mutation Database (HGMD)
ZCCHC13
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZCCHC13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZCCHC13 Gene

Disorders for ZCCHC13 Gene

Additional Disease Information for ZCCHC13

No disorders were found for ZCCHC13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZCCHC13 Gene

Publications for ZCCHC13 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  3. A software application for comparing large numbers of high resolution MALDI-FTICR MS spectra demonstrated by searching candidate biomarkers for glioma blood vessel formation. (PMID: 18312684) Titulaer MK … Luider TM (BMC bioinformatics 2008) 3 58
  4. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PMID: 17903301) Vasan RS … Benjamin EJ (BMC medical genetics 2007) 44 58
  5. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PMID: 16713569) Lim J … Zoghbi HY (Cell 2006) 3 58

Products for ZCCHC13 Gene

Sources for ZCCHC13 Gene

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