ZCCHC12 Gene
protein-coding GIFtS : 50
GCID: GC0X P117958
zinc finger, CCHC domain containing 12
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Aliasesfor ZCCHC12 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Zinc Finger, CCHC Domain Containing 12 1 2 FLJ161231 SIZN11 2 3 5 2810028A01Rik2 PNMA7A1 2 Paraneoplastic Ma Antigen Family Member 7A2 SIZN1 2 Zinc Finger CCHC Domain-Containing Protein 122 Smad-Interacting Zinc Finger Protein 12 3
Export aliases for ZCCHC12 gene to outside databases Previous GC identifers: GC0XP117739 GC0XP117841 GC0XP107450
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Summariesfor ZCCHC12 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: ZCH12_HUMAN, Q6PEW1 Function : Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positivelymodulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression (By similarity)
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Genomic Viewsfor ZCCHC12 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000023.10 NC_018934.1 NT_011786.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ZCCHC12 gene promoter: GR GR-beta Nkx2-2 Meis-1b POU2F1 POU2F1a c-Myb GR-alpha Meis-1a Meis-1 Other transcription factors Search SABiosciences Chromatin IP Primers for ZCCHC12 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZCCHC12
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: Xq24 Ensembl cytogenetic band: Xq24 HGNC cytogenetic band: Xq24 ZCCHC12 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XP117958: view genomic region
(about GC identifiers )
Start:
117,957,753 bp from pter
End:
117,960,931 bp from pter
Size:
3,179 bases
Orientation:
plus strand
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Proteinsfor ZCCHC12 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ZCH12_HUMAN, Q6PEW1 (See
protein sequence )Recommended Name: Zinc finger CCHC domain-containing protein 12 Size : 402 amino acids; 45369 Da
Subunit : Interacts with SMAD1 and CREB-binding protein (CBP). Forms a protein-DNA complex through its association withSMAD1 (By similarity)
Secondary accessions : B3KV48 Q6PID5 Q8N1C1Explore the universe of human proteins at neXtProt for ZCCHC12: NX_Q6PEW1 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q6PEW1 ZCCHC12 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_776159.1 ENSEMBL proteins: ENSP00000308921 Human Recombinant Protein Products: ZCCHC12 Antibody Products: Assay Products for ZCCHC12:
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Protein
Domains / Familiesfor ZCCHC12 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ZCCHC12 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q6PEW1 ProtoNet protein and cluster: Q6PEW1
1 Blocks protein family : IPB001878 C2HC-type zinc-finger signature UniProtKB/Swiss-Prot: ZCH12_HUMAN, Q6PEW1 Similarity : Belongs to the ZCCHC12 familySimilarity : Contains 1 CCHC-type zinc finger
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Functionfor ZCCHC12 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: ZCH12_HUMAN, Q6PEW1 Function : Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positivelymodulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression (By similarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ZCCHC12 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ZCCHC12OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ZCCHC12 (NM_173798 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZCCHC12 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ZCCHC12
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCCHC12
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003676 nucleic acid binding
IEA -- GO:0008270 zinc ion binding
IEA --
ZCCHC12 for ontologies About GeneDecksing
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Pathways & Interactionsfor ZCCHC12 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Regulation of Wnt-mediated beta catenin signaling and target gene transcription
1 BioSystems Pathway for ZCCHC12 Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZCCHC12 STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)5 Interacting proteins for ZCCHC12 (Q6PEW1 3 ENSP00000308921 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006351 transcription, DNA-dependent
IEA -- GO:0006355 regulation of transcription, DNA-dependent
IEA --
ZCCHC12 for ontologies About GeneDecksing
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Drugs & Compoundsfor ZCCHC12 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for ZCCHC12 Search CenterWatch for drugs/clinical trials and news about ZCCHC12 / ZCH12
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Transcriptsfor ZCCHC12 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ZCCHC12 gene: NM_173798.2 Unigene Cluster for ZCCHC12:
Zinc finger, CCHC domain containing 12 Hs.21417 [show with all ESTs ] Unigene Representative Sequence: BC036572 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000310164 (uc004equ.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ZCCHC12 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ZCCHC12OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ZCCHC12 (NM_173798 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZCCHC12 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ZCCHC12
Additional cDNA sequence: AK122676.1 BC018066.1 BC031241.1 BC033958.2 BC036572.2 BC057841.1
2 DOTS entries : DT.101981697 DT.100831193
24/63 AceView cDNA sequences (see all 63 ):
Z43767 AA350584 CR594993 CD106923 AK122676 NM_173798 AW002115 T08146 BC031241 BX422752 BI599552 AA350585 AW572373 BI546315 BG706249 BX422751 BX441965 BI666934 BI549702 AI955956 BC036572 AI049548 BI600056 BX452503 GeneLoc Exon Structure
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Expression for ZCCHC12 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ZCCHC12 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AATTAATCCA
About this image ZCCHC12 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See ZCCHC12 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ZCCHC12 SOURCE GeneReport for Unigene cluster: Hs.21417 SABiosciences Custom PCR Arrays for ZCCHC12 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ZCCHC12Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ZCCHC12 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ZCCHC12 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ZCCHC12 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCCHC12
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Orthologsfor ZCCHC12 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
--
ENSEMBL Gene Tree for ZCCHC12 (if available)TreeFam Gene Tree for ZCCHC12 (if available)
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Paralogsfor ZCCHC12 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ZCCHC12 gene PNMA6A 2 PNMA5 2 PNMA1 2 PNMA6D 2 PNMA2 2 PNMA3 2 PNMA6C 2 MOAP1 2 PNMAL2 2 PNMAL1 2 PNMA6B 2 2 SIMAP similar genes for ZCCHC12 using alignment to 1 protein entry: ZCH12_HUMAN :ZCCHC18 PNMA1
ZCCHC12 for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for ZCCHC12 PGOHUM00000241934
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Genomic Variantsfor ZCCHC12 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr X pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ZCCHC12 (117957753 - 117960931 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 4 variations for ZCCHC12 4 Indels : 83701 83702 96916 96917 Human Gene Mutation Database (HGMD) : ZCCHC12 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ZCCHC12
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Disorders
/ Diseasesfor ZCCHC12 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
ZCCHC12 for disorders About GeneDecksing
OMIM gene information: 300701
OMIM disorders : --4 diseases for ZCCHC12 : About MalaCards intellectual disability leukemia neuronitis carcinoma 1 disease from the University of Copenhagen DISEASES database for ZCCHC12 :Intellectual disability Export disorders for ZCCHC12 gene to outside databases
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Publicationsfor ZCCHC12 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ZCCHC12 gene, integrated from 9 sources (see all 13 ): (articles sorted by number of sources associating them with ZCCHC12) Utopia : connect your pdf to the dynamic world of online information
ZCCHC12, a potential molecular marker of papillary th yroid carcinoma: a preliminary study. (PubMed id 21739307) 1 , 3 Li Q.L....Yang A.K. (2011) Human ZCCHC12 activates AP-1 and CREB signaling as a transcriptional co-activator. (PubMed id 19578717) 1 , 3 Li H....Zhang J. (2009) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) SUMO interaction motifs in Sizn1 are required for pro myelocytic leukemia protein nuclear body localization and for transcriptional a ctivation. (PubMed id 19416967) 1 Cho G....Golden J.A. (2009) Sizn1 is a novel protein that functions as a transcriptional coactivator of bone morphogenic protein signaling. (PubMed id 18160706) 1 Cho G....Golden J.A. (2008)
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External Searches for ZCCHC12 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ZCCHC12 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ZCCHC12 gene
(According to HUGE )
About This Section --
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Specialized Databases showing ZCCHC12 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ZCCHC12 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for ZCCHC12 gene: Search GeneIP for patents involving ZCCHC12 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ZCCHC12 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for ZCCHC12 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ZCCHC12 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ZCCHC12 OriGene Protein Over-expression Lysate for ZCCHC12 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ZCCHC12 OriGene 3'-UTR Clone for ZCCHC12 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ZCCHC12 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ZCCHC12 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ZCCHC12 OriGene Custom Protein Services for ZCCHC12 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZCCHC12 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ZCCHC12 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZCCHC12 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ZCCHC12 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ZCCHC12 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ZCCHC12
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ZCCHC12 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCCHC12
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ZCCHC12
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Aliases for ZCCHC12
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Disorders / Diseases for ZCCHC12
Domains / Families for ZCCHC12
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Expression for ZCCHC12
Function for ZCCHC12
Genomic Views for ZCCHC12
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