Aliases for ZCCHC12 Gene
External Ids for ZCCHC12 Gene
Previous GeneCards Identifiers for ZCCHC12 Gene
This gene encodes a downstream effector of bone morphogenetic protein (BMP) signalling. This protein contains a zinc finger domain and functions as a transcriptional coactivator. Variation in this gene may be associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
GeneCards Summary for ZCCHC12 Gene
ZCCHC12 (Zinc Finger CCHC-Type Containing 12) is a Protein Coding gene. Diseases associated with ZCCHC12 include nodular goiter. Among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription. GO annotations related to this gene include nucleic acid binding and ligand-dependent nuclear receptor transcription coactivator activity. An important paralog of this gene is PNMA2.
UniProtKB/Swiss-Prot for ZCCHC12 Gene
Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression (By similarity).