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ZCCHC12 Gene

protein-coding   GIFtS: 50
GCID: GC0XP117958

Zinc Finger, CCHC Domain Containing 12

  See ZCCHC12-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, CCHC Domain Containing 121 2     2810028A01Rik2
SIZN12 3 5     PNMA7A2
Paraneoplastic Ma Antigen Family Member 7A1 2     SIZN2
Smad-Interacting Zinc Finger Protein 12 3     Zinc Finger CCHC Domain-Containing Protein 122

External Ids:    HGNC: 272731   Entrez Gene: 1702612   Ensembl: ENSG000001744607   OMIM: 3007015   UniProtKB: Q6PEW13   

Export aliases for ZCCHC12 gene to outside databases

Previous GC identifers: GC0XP117739 GC0XP117841 GC0XP107450


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZCCHC12 Gene:
ZCCHC12 (zinc finger, CCHC domain containing 12) is a protein-coding gene. Diseases associated with ZCCHC12 include papillary thyroid carcinoma. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is PNMA6A.

UniProtKB/Swiss-Prot: ZCH12_HUMAN, Q6PEW1
Function: Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively
modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It
contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011786.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZCCHC12 gene promoter:
         GR   GR-beta   Nkx2-2   Meis-1b   POU2F1   POU2F1a   c-Myb   GR-alpha   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZCCHC12 promoter sequence
   Search Chromatin IP Primers for ZCCHC12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZCCHC12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq24   Ensembl cytogenetic band:  Xq24   HGNC cytogenetic band: Xq24

ZCCHC12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZCCHC12 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP117958:  view genomic region     (about GC identifiers)

Start:
117,957,753 bp from pter      End:
117,960,931 bp from pter
Size:
3,179 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZCH12_HUMAN, Q6PEW1 (See protein sequence)
Recommended Name: Zinc finger CCHC domain-containing protein 12  
Size: 402 amino acids; 45369 Da
Subunit: Interacts with SMAD1 and CREB-binding protein (CBP). Forms a protein-DNA complex through its association
with SMAD1 (By similarity)
Secondary accessions: B3KV48 Q6PID5 Q8N1C1

Explore the universe of human proteins at neXtProt for ZCCHC12: NX_Q6PEW1

Explore proteomics data for ZCCHC12 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZCCHC12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_776159.1  
    ENSEMBL proteins: 
     ENSP00000308921  

    ZCCHC12 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZCCHC: Zinc fingers, CCHC domain containing
    PNMA: Paraneoplastic Ma antigens

    1 InterPro protein domain:
     IPR001878 Znf_CCHC

    Graphical View of Domain Structure for InterPro Entry Q6PEW1

    ProtoNet protein and cluster: Q6PEW1

    1 Blocks protein domain: IPB001878 C2HC-type zinc-finger signature

    UniProtKB/Swiss-Prot: ZCH12_HUMAN, Q6PEW1
    Similarity: Belongs to the ZCCHC12 family
    Similarity: Contains 1 CCHC-type zinc finger


    Find genes that share domains with ZCCHC12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZCH12_HUMAN, Q6PEW1
    Function: Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively
    modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It
    contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0008270zinc ion binding IEA--
    GO:0030374ligand-dependent nuclear receptor transcription coactivator activity IBA--
         
    Find genes that share ontologies with ZCCHC12           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZCCHC12
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    miRNA
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    miRTarBase miRNAs that target ZCCHC12:
    hsa-mir-615-3p (MIRT039800)

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    6 qRT-PCR Assays for microRNAs that regulate ZCCHC12:
    hsa-miR-380* hsa-miR-513b hsa-miR-563 hsa-miR-376c hsa-miR-296-3p hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmidZCCHC12 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    mitochondrion2
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016607nuclear speck IBA--

    Find genes that share ontologies with ZCCHC12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZCCHC12 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription


    1 BioSystems Pathway for ZCCHC12
        Regulation of Wnt-mediated beta catenin signaling and target gene transcription



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZCCHC12
    Interactions:

        Search GeneGlobe Interaction Network for ZCCHC12

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for ZCCHC12 (Q6PEW13 ENSP000003089214) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPBP2Q926243, ENSP000000831824I2D: score=3 STRING: ENSP00000083182
    SMAD1Q157973, ENSP000003057694I2D: score=1 STRING: ENSP00000305769
    TCF7L2ENSP000003584044STRING: ENSP00000358404
    CTNNB1ENSP000003444564STRING: ENSP00000344456
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0030509BMP signaling pathway IBA--

    Find genes that share ontologies with ZCCHC12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZCCHC12 (ZCH12)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZCCHC12 gene: 
    NM_173798.2  

    Unigene Cluster for ZCCHC12:

    Zinc finger, CCHC domain containing 12
    Hs.21417  [show with all ESTs]
    Unigene Representative Sequence: BC036572
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000310164(uc004equ.3)
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate ZCCHC12:
    hsa-miR-380* hsa-miR-513b hsa-miR-563 hsa-miR-376c hsa-miR-296-3p hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmidZCCHC12 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZCCHC12
      QuantiTect SYBR Green Assays in human, mouse, rat ZCCHC12
      QuantiFast Probe-based Assays in human, mouse, rat ZCCHC12

    Additional mRNA sequence: 

    AK122676.1 BC018066.1 BC031241.1 BC033958.2 BC036572.2 BC057841.1 

    2 DOTS entries:

    DT.101981697  DT.100831193 

    Selected AceView cDNA sequences (see all 63):

    Z43767 CR594993 CD106923 AK122676 NM_173798 T08146 BC031241 AW002115 
    AA350584 BI549702 BI546315 BG706537 BX453739 BG700477 BI666934 BX422751 
    AI049548 BI551934 BC018066 BI551295 BX452503 BC057841 BI600056 BI599552 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZCCHC12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTAATCCA
    ZCCHC12 Expression
    About this image


    ZCCHC12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
             Cerebellum
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
     
     Endothelium (Cardiovascular System)
             Endothelial Cells Blood Brain Barrier
     
     Adipose (Muscoskeletal System)
             Mesenchymal Stem Cells Subcutaneous White Adipose
    ZCCHC12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZCCHC12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.21417
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZCCHC12 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zcchc121 , 5 zinc finger, CCHC domain containing 121, 5 81.83(n)1
    75(a)1
      X (20.58 cM)5
    726931  NM_028325.31  NP_082601.11 
     361959045 


    ENSEMBL Gene Tree for ZCCHC12 (if available)
    TreeFam Gene Tree for ZCCHC12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZCCHC12 gene
    PNMA6A2  PNMA52  PNMA12  PNMA6D2  PNMA22  PNMAL22  PNMA6C2  MOAP12  
    PNMA32  ZCCHC182  PNMAL12  PNMA6B2  
    2 SIMAP similar genes for ZCCHC12 using alignment to 1 protein entry:     ZCH12_HUMAN:
    ZCCHC18    PNMA1

    Find genes that share paralogs with ZCCHC12           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZCCHC12
    PGOHUM00000241934


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZCCHC12 (see all 105)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1898406751,2
    --117955879(+) CCTCAG/TTACCT 1 -- us2k10--------
    rs1424499141,2
    --117956029(+) ATATGA/CACAGA 1 -- us2k10--------
    rs1831729821,2
    --117956147(+) ATGAGC/TAATAC 1 -- us2k10--------
    rs1119605141,2
    C--117956533(+) CACCTA/GCAAAG 1 -- us2k10--------
    rs15136421,2
    C--117956540(+) AAAGAC/TCATTT 1 -- us2k10--------
    rs1864494401,2
    --117956696(+) GTTGCA/GTTTCA 1 -- us2k10--------
    rs1478236761,2
    --117956738(+) AGGCTC/TATTTA 1 -- us2k10--------
    rs117971411,2
    C,H--117956876(+) ACATTT/GCTTTT 1 -- us2k1 tfbs3 trp32Minor allele frequency- G:0.17NA 6
    rs1904708371,2
    --117956964(+) TGCAGC/TGGTGC 1 -- us2k10--------
    rs128531361,2
    A,H--117957016(+) attctC/Ttagcc 1 -- us2k14Minor allele frequency- T:0.00NS EA 418

    HapMap Linkage Disequilibrium report for ZCCHC12 (117957753 - 117960931 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZCCHC12:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv527n21CNV Gain19592680

    Human Gene Mutation Database (HGMD): ZCCHC12
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZCCHC12
    DNA2.0 Custom Variant and Variant Library Synthesis for ZCCHC12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300701    OMIM disorders: --

    1 disease for ZCCHC12:    
    About MalaCards
    papillary thyroid carcinoma

    1 disease from the University of Copenhagen DISEASES database for ZCCHC12:
    Intellectual disability

    Find genes that share disorders with ZCCHC12           About GenesLikeMe


    Export disorders for ZCCHC12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZCCHC12 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with ZCCHC12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ZCCHC12, a potential molecular marker of papillary thyroid carcinoma: a preliminary study. (PubMed id 21739307)1, 3 Li Q.L....Yang A.K. (Med. Oncol. 2012)
    2. Human ZCCHC12 activates AP-1 and CREB signaling as a transcriptional co-activator. (PubMed id 19578717)1, 3 Li H....Zhang J. (Acta Biochim. Biophys. Sin. (Shanghai) 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. SUMO interaction motifs in Sizn1 are required for promyelocytic leukemia protein nuclear body localization and for transcriptional activation. (PubMed id 19416967)1 Cho G....Golden J.A. (J. Biol. Chem. 2009)
    9. Sizn1 is a novel protein that functions as a transcriptional coactivator of bone morphogenic protein signaling. (PubMed id 18160706)1 Cho G....Golden J.A. (Mol. Cell. Biol. 2008)
    10. Evidence that SIZN1 is a candidate X-linked mental retardation gene. (PubMed id 18798319)1 Cho G....Srivastava A.K. (Am. J. Med. Genet. A 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Free Text  

      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 170261 HGNC: 27273 AceView: ZCCHC12 Ensembl:ENSG00000174460 euGenes: HUgn170261
    ECgene: ZCCHC12 H-InvDB: ZCCHC12

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZCCHC12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZCCHC12 gene:
    Search GeneIP for patents involving ZCCHC12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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