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Aliases & Descriptions for ZCCHC12
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| 2810028A01Rik 2 | | FLJ16123 1, 2 | | OTTHUMP00000023892 2 | | SIZN 1, 2 | | SIZN1 1, 2, 3, 5 |
| | | Descriptions |
|---|
| Smad-interacting zinc finger protein 1 3 | | zinc finger, CCHC domain containing 12 2 |
|
| | Search outside databases for aliases for ZCCHC12 genePrevious GC identifer: GC0XP117739 |
Summaries for ZCCHC12(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: ZCH12_HUMAN, Q6PEW1Function: Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression (By similarity) |
Genomic Location for ZCCHC12
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ZCCHC12 gene 
Entrez Gene cytogenetic band: Xq24 Ensembl cytogenetic band: Xq24 HGNC cytogenetic band: Xq24ZCCHC12 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP117841:
(about GC identifiers)
Start:
|
117,841,774 bp from pter |
End:
|
117,844,959 bp from pter |
Size:
|
3,186 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000023.9 NT_011786.15
| Proteins for ZCCHC12
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ZCH12_HUMAN, Q6PEW1 (See
protein sequence)Recommended Name: Zinc finger CCHC domain-containing protein 12 Size: 402 amino acids; 45369 Da
Subunit: Interacts with SMAD1 and CREB-binding protein (CBP). Forms a protein-DNA complex through its association with SMAD1 (By similarity)
Secondary accessions: Q6PID5 Q8N1C1Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_776159.1
ENSEMBL proteins: ENSP00000308921
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
Antibodies for ZCCHC12: Assays for ZCCHC12: | Protein
Domains/ Families for ZCCHC12(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q6PEW1
ProtoNet protein and cluster: Q6PEW1 1 Blocks protein family: IPB001878 C2HC-type zinc-finger signature
UniProtKB/Swiss-Prot: ZCH12_HUMAN, Q6PEW1Similarity: Contains 1 CCHC-type zinc finger | Gene Function for ZCCHC12
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_173798
Applied Biosystems Silencer® siRNAs for ZCCHC12
Sigma-Aldrich siRNA for ZCCHC12  Sigma-Aldrich shRNA for ZCCHC12  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_173798                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_173798                                  untagged cDNA clone in CMV expression vector: NM_173798 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_173798
UniProtKB/Swiss-Prot: ZCH12_HUMAN, Q6PEW1Function: Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression (By similarity)1 MGI phenotypic allele for Zcchc12 (no phenotypes)
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for ZCCHC12
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| --2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006350 | transcription |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | About this table
|
Drugs & Compounds for ZCCHC12(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for ZCCHC12
|
Transcripts for ZCCHC12(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_173798
Sigma-Aldrich siRNA for ZCCHC12  Sigma-Aldrich shRNA for ZCCHC12  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_173798 REFSEQ mRNAs for ZCCHC12 gene: NM_173798.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_173798               OriGene GFP tagged cDNA clone in CMV expression vector: NM_173798                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_173798                                  untagged cDNA clone in CMV expression vector: NM_173798  Additional cDNA sequence: AK122676.1 BC018066.1 BC031241.1 BC033958.2 BC036572.2 BC057841.1 CR594993.1 2 DOTS entries: DT.101981697 DT.100831193 24/63 AceView cDNA sequences (see all 63
):CR594993 CD106923 Z43767 BC031241 T08146 NM_173798 AA350584 AW002115 AK122676 AI263334 BI598817 BG700477 BX453739 BI551934 AW572373 M78481 BG708033 BI666934 BC057841 BI600056 AA350585 BX422751 BI667999 BC033958
highest scoring ESTs for ZCCHC12:AA350585 AI049548 AI263334 AI923298 AI955956 AK122676 AL536985 AL602896 AL703272 AV725825 Unigene Cluster for ZCCHC12: Zinc finger, CCHC domain containing 12 Hs.21417 [show with all ESTs]Unigene Representative Sequence: BC036572
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000310164
|
Expression for ZCCHC12
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ZCCHC12 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ZCCHC12
1 / 2 / 3 3 probe-sets matching ZCCHC12 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AATTAATCCA
SOURCE GeneReport for Unigene cluster: Hs.21417
|
Orthologs for ZCCHC12
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ZCCHC12 gene from 5 species
About this table Species with no ortholog for ZCCHC12
ENSEMBL Gene Tree for ZCCHC12 | Paralogs for ZCCHC12(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ZCCHC12 gene
- PNMA6A2 PNMA52 PNMA12 PNMA22 PNMA32 MOAP12 ENSG000002048512 ZCCHC182
- PNMAL12 PNMA6B2
|
SNPs/Variants for ZCCHC12(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ZCCHC12 (up to first 250kb)
|
Disorders & Mutations for ZCCHC12
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 300701
Human Gene Mutation Database: ZCCHC12
|
Medical News for ZCCHC12(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ZCCHC12 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 6 PubMed articles for ZCCHC12 gene: |
Search for ZCCHC12
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ZCCHC12
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ZCCHC12
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZCCHC12(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for ZCCHC12(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ZCCHC12:

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Incremental update: 13 Oct 2009
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