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Aliases & Descriptions for ZCCHC11
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases KIAA0191 1 , 3 OTTHUMP00000009913 2 PAPD3 1 , 2
Descriptions PAP associated domain containing 3 2 zinc finger, CCHC domain containing 11 2
Search outside databases for aliases for ZCCHC11 genePrevious GC identifers: GC01M052259 GC01M052601
Summaries for ZCCHC11 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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UniProtKB/Swiss-Prot: ZCH11_HUMAN, Q5TAX3 Function : Suppresses Toll-like receptor-induced NF-kappa-B activity via binding to T2BP
Genomic Location for ZCCHC11
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the ZCCHC11 gene Entrez Gene cytogenetic band: 1p32.3 Ensembl cytogenetic band: 1p32.3 HGNC cytogenetic band: 1p32.3 ZCCHC11 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M052661:
(about GC identifiers )
Start:
52,661,535 bp from pter
End:
52,791,331 bp from pter
Size:
129,797 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000001.9 NT_032977.8 Proteins for ZCCHC11
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: ZCH11_HUMAN, Q5TAX3 (See
protein sequence )Recommended Name: Zinc finger CCHC domain-containing protein 11 Size : 1644 amino acids; 185166 Da
Subunit : Interacts with T2BP
Subcellular location : Nucleus. Cytoplasm. Note=Translocates into the cytoplasm following treatmentof the cell with LPS
Secondary accessions : A2RRP0 Q12764 Q5TAX4 Q86XZ3Alternative splicing : 2 isoforms : Q5TAX3-1 Q5TAX3-2
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (3 alternative transcripts):
NP_001009881.1 NP_001009882.1 NP_056084.1 ENSEMBL proteins: ENSP00000360599 ENSP00000257177 ENSP00000348063 ENSP00000360596 ENSP00000379252 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 3 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for ZCCHC11: Assays for ZCCHC11:
Protein
Domains/ Families for ZCCHC11(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q5TAX3 ProtoNet protein and cluster: Q5TAX3
2 Blocks protein families : IPB002058 PAP/25A-associated domain IPB002934 DNA polymerase UniProtKB/Swiss-Prot: ZCH11_HUMAN, Q5TAX3 Similarity : Contains 3 CCHC-type zinc fingers
Gene Function for ZCCHC11
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4 ): XM_038288 Applied Biosystems Silencer ® siRNAs for ZCCHC11 Sigma-Aldrich siRNA and siRNA Panels for ZCCHC11 Sigma-Aldrich shRNA for ZCCHC11 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001009881                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001009881                                  untagged cDNA clones in CMV expression vector (see all 4 ): NM_001009881  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001009881 UniProtKB/Swiss-Prot: ZCH11_HUMAN, Q5TAX3 Function : Suppresses Toll-like receptor-induced NF-kappa-B activity via binding to T2BP
5 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for ZCCHC11
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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1 Interacting protein for ZCCHC11 (Q5TAX3 1 ) via UniProtKB, MINT, and/or STRING About this table
Drugs & Compounds for ZCCHC11 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for ZCCHC11
Transcripts for ZCCHC11(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
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shRNA from
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OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4 ): XM_038288 Sigma-Aldrich siRNA and siRNA Panels for ZCCHC11 Sigma-Aldrich shRNA for ZCCHC11 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001009881 NM_001009882 NM_015269
REFSEQ mRNAs for ZCCHC11 gene (3 alternative transcripts): NM_001009881.1 NM_001009882.1 NM_015269.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001009881 NM_001009882 NM_015269
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001009881                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001009881                                  untagged cDNA clones in CMV expression vector (see all 4 ): NM_001009881  
Additional cDNA sequence: AK025698.1 AK095733.1 AK124868.1 AK303532.1 AK307579.1 AK308427.1 BC012047.1 BC018753.1 BC035820.1 BC131734.1 BX648248.1 BX648783.1 BX649065.1 CR604717.1 CR616727.1 D83776.1
16 DOTS entries : DT.452033 DT.75146298 DT.101983757 DT.101983756 DT.100833179 DT.100718308 DT.121437962 DT.92428730 DT.121438013 DT.121438023 DT.91730437 DT.91994395 DT.92056723 DT.40269555 DT.95261567 DT.99949609
24/160 AceView cDNA sequences (see all 160
):F10702 BU178489 AV714171 BC012047 AK025698 F13102 AL045167 CB132120 BQ889323 BX439159 AA304813 BC018753 CA449372 CR616727 AI076173 AA431368 BQ430408 AA428502 AL705626 BG536205 AV709185 AI049962 AK095733 BM450281
highest scoring ESTs for ZCCHC11 :AA813882 AK095733 AL704521 AL710106 AW976716 BC035820 BE274136 BE275797 BG942947 BM467327
Unigene Cluster for ZCCHC11: Zinc finger, CCHC domain containing 11 Hs.655407 [show with all ESTs ] Unigene Representative Sequence: NM_001009881 GeneLoc Exon Structure 5/14 Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC11 (see all 14
) ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ SP1 :                                         -       -       SP2 :                                                     SP3 :                                                     SP4 :                                                     SP5 :                               -                      
ExUns: 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b · 29c · 29d ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35a · 35b · 35c · 35d SP1 :                               -                   SP2 :                               -                   SP3 :                     -           -                   SP4 :                               -           -         SP5 :                                                
About this scheme ECgene alternative splicing isoforms for ZCCHC11 5 Ensembl transcripts including schematic representations : ENST00000371544
ENST00000257177
ENST00000355809
ENST00000371541
ENST00000395916
Expression for ZCCHC11
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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ZCCHC11 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for ZCCHC11 1 / 2 / 3
8 probe-sets matching ZCCHC11 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: AAGATTCAGASOURCE GeneReport for Unigene cluster: Hs.655407 Expression variation in blood from EXPOLDB for ZCCHC11
Orthologs for ZCCHC11
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for ZCCHC11 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for ZCCHC11 ENSEMBL Gene Tree for ZCCHC11 Paralogs for ZCCHC11 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for ZCCHC11 gene ZCCHC6 2 PAPD4 2
SNPs/Variants for ZCCHC11 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for ZCCHC11 (up to first 250kb)
Disorders & Mutations for ZCCHC11
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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--
Medical News for ZCCHC11 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for ZCCHC11 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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8 PubMed articles for ZCCHC11 gene : Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8724849) 2, 3, 4 Nagase T....Nomura N. (1996) A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling. (PubMed id 16643855) 3, 4 Minoda Y....Yoshimura A. (2006) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 3, 4 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Gene regulation: reviving the message. (PubMed id 12239557) 2, 3 Keller W. and Martin G. (2002) ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332) 4 Matsuoka S.... Elledge S.J. (2007) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3 Ota T....Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002)
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Genome Databases showing ZCCHC11
(According to
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euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing ZCCHC11
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Specialized Databases showing ZCCHC11 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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