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Aliases for ZCCHC11 Gene

Aliases for ZCCHC11 Gene

  • Zinc Finger, CCHC Domain Containing 11 2 3
  • Zinc Finger CCHC Domain-Containing Protein 11 3 4
  • TUTase 4 3 4
  • KIAA0191 4 6
  • TUT4 3 4
  • PAP Associated Domain Containing 3 3
  • Terminal Uridylyltransferase 4 3
  • EC 2.7.7.52 4
  • TUTase4 2
  • PAPD3 3

External Ids for ZCCHC11 Gene

Previous GeneCards Identifiers for ZCCHC11 Gene

  • GC01M052259
  • GC01M052601
  • GC01M052661
  • GC01M052888
  • GC01M051004

Summaries for ZCCHC11 Gene

Entrez Gene Summary for ZCCHC11 Gene

  • ZCCHC11 is an RNA uridyltransferase (EC 2.7.7.52) that uses UTP to add uridines to the 3-prime end of substrate RNA molecules (Jones et al., 2009 [PubMed 19701194]).[supplied by OMIM, Jan 2011]

GeneCards Summary for ZCCHC11 Gene

ZCCHC11 (Zinc Finger, CCHC Domain Containing 11) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA uridylyltransferase activity. An important paralog of this gene is TUT1.

UniProtKB/Swiss-Prot for ZCCHC11 Gene

  • Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3 uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B. Also catalyzes the 3 uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCCHC11 Gene

Genomics for ZCCHC11 Gene

Regulatory Elements for ZCCHC11 Gene

Genomic Location for ZCCHC11 Gene

Start:
52,408,282 bp from pter
End:
52,553,487 bp from pter
Size:
145,206 bases
Orientation:
Minus strand

Genomic View for ZCCHC11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZCCHC11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCCHC11 Gene

Proteins for ZCCHC11 Gene

  • Protein details for ZCCHC11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TAX3-TUT4_HUMAN
    Recommended name:
    Terminal uridylyltransferase 4
    Protein Accession:
    Q5TAX3
    Secondary Accessions:
    • A2RRP0
    • B7Z8J5
    • D3DQ35
    • Q12764
    • Q5TAX2
    • Q5TAX4
    • Q86XZ3

    Protein attributes for ZCCHC11 Gene

    Size:
    1644 amino acids
    Molecular mass:
    185166 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Interacts with LIN28A, LIN28B and T2BP.
    SequenceCaution:
    • Sequence=CAI23477.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZCCHC11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZCCHC11 Gene

Proteomics data for ZCCHC11 Gene at MOPED

Post-translational modifications for ZCCHC11 Gene

  • Ubiquitination at Lys680, Lys1000, Lys1036, and Lys1260
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZCCHC11 Gene

Domains for ZCCHC11 Gene

Gene Families for ZCCHC11 Gene

HGNC:
  • ZCCHC :Zinc fingers, CCHC domain containing

Protein Domains for ZCCHC11 Gene

Suggested Antigen Peptide Sequences for ZCCHC11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5TAX3

UniProtKB/Swiss-Prot:

TUT4_HUMAN :
  • Q5TAX3
Domain:
  • Contains 2 PAP-associated domains.
Family:
  • Belongs to the DNA polymerase type-B-like family.
Similarity:
  • Contains 3 CCHC-type zinc fingers.
genes like me logo Genes that share domains with ZCCHC11: view

Function for ZCCHC11 Gene

Molecular function for ZCCHC11 Gene

UniProtKB/Swiss-Prot CatalyticActivity: UTP + RNA(n) = diphosphate + RNA(n+1).
UniProtKB/Swiss-Prot Function: Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3 uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B. Also catalyzes the 3 uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation.

Enzyme Numbers (IUBMB) for ZCCHC11 Gene

Gene Ontology (GO) - Molecular Function for ZCCHC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 16643855
GO:0008270 zinc ion binding IEA --
GO:0016779 nucleotidyltransferase activity --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ZCCHC11: view
genes like me logo Genes that share phenotypes with ZCCHC11: view

miRNA for ZCCHC11 Gene

miRTarBase miRNAs that target ZCCHC11

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ZCCHC11 Gene

Localization for ZCCHC11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZCCHC11 Gene

Nucleus. Cytoplasm. Note=Translocates into the cytoplasm following treatment of the cell with LPS.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZCCHC11 Gene COMPARTMENTS Subcellular localization image for ZCCHC11 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZCCHC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005634 nucleus --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ZCCHC11: view

Pathways for ZCCHC11 Gene

SuperPathways for ZCCHC11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZCCHC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production IEA --
GO:0008152 metabolic process --
GO:0010586 miRNA metabolic process ISS --
GO:0010587 miRNA catabolic process IMP 19703396
GO:0019827 stem cell maintenance IMP 19703396
genes like me logo Genes that share ontologies with ZCCHC11: view

No data available for Pathways by source for ZCCHC11 Gene

Transcripts for ZCCHC11 Gene

Unigene Clusters for ZCCHC11 Gene

Zinc finger, CCHC domain containing 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^
SP1: - -
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7: - - - -
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13: - -
SP14:

ExUns: 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b · 29c · 29d ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35a · 35b · 35c · 35d
SP1: -
SP2: -
SP3: - -
SP4: - -
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for ZCCHC11 Gene

GeneLoc Exon Structure for
ZCCHC11
ECgene alternative splicing isoforms for
ZCCHC11

Expression for ZCCHC11 Gene

mRNA expression in normal human tissues for ZCCHC11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZCCHC11 Gene

SOURCE GeneReport for Unigene cluster for ZCCHC11 Gene Hs.655407

genes like me logo Genes that share expressions with ZCCHC11: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZCCHC11 Gene

Orthologs for ZCCHC11 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZCCHC11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZCCHC11 35
  • 99.66 (n)
  • 99.51 (a)
ZCCHC11 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC528986 35
  • 92.69 (n)
  • 91.2 (a)
ZCCHC11 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZCCHC11 35
  • 92.76 (n)
  • 91.31 (a)
ZCCHC11 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zcchc11 35
  • 89.11 (n)
  • 89.01 (a)
Zcchc11 16
Zcchc11 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZCCHC11 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZCCHC11 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zcchc11 35
  • 88.51 (n)
  • 88.3 (a)
chicken
(Gallus gallus)
Aves ZCCHC11 35
  • 73.79 (n)
  • 70.58 (a)
ZCCHC11 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZCCHC11 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15797 35
zcchc11 35
  • 65.48 (n)
  • 64.24 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.17857 35
LOC795358 35
  • 64.94 (n)
  • 67.05 (a)
zcchc11 36
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mkg-p 36
  • 15 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea cid-1 36
  • 20 (a)
ManyToMany
pup-2 36
  • 26 (a)
ManyToMany
Y34F4.3 36
  • 20 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4240 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5065 36
  • 41 (a)
OneToMany
Species with no ortholog for ZCCHC11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZCCHC11 Gene

ENSEMBL:
Gene Tree for ZCCHC11 (if available)
TreeFam:
Gene Tree for ZCCHC11 (if available)

Paralogs for ZCCHC11 Gene

Paralogs for ZCCHC11 Gene

genes like me logo Genes that share paralogs with ZCCHC11: view

Variants for ZCCHC11 Gene

Sequence variations from dbSNP and Humsavar for ZCCHC11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs766344 -- 52,424,841(+) TATGG(G/T)CTAAG intron-variant
rs835028 -- 52,466,682(-) aaaaa(A/T)atata intron-variant
rs835029 -- 52,462,297(-) gagac(A/G)ggaga intron-variant, utr-variant-3-prime, downstream-variant-500B
rs835030 -- 52,428,225(-) caggc(A/G)tgagc intron-variant
rs835031 -- 52,423,265(-) GTTAA(A/T)CTGTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ZCCHC11 Gene

Variant ID Type Subtype PubMed ID
esv988243 CNV Insertion 20482838

Relevant External Links for ZCCHC11 Gene

HapMap Linkage Disequilibrium report
ZCCHC11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZCCHC11 Gene

Disorders for ZCCHC11 Gene

Relevant External Links for ZCCHC11

Genetic Association Database (GAD)
ZCCHC11
Human Genome Epidemiology (HuGE) Navigator
ZCCHC11
genes like me logo Genes that share disorders with ZCCHC11: view

No data available for UniProtKB/Swiss-Prot for ZCCHC11 Gene

Publications for ZCCHC11 Gene

  1. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8724849) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4
  2. Gene regulation: reviving the message. (PMID: 12239557) Keller W. … Martin G. (Nature 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'. (PMID: 18172165) Mullen T.E. … Marzluff W.F. (Genes Dev. 2008) 3 4

Products for ZCCHC11 Gene

Sources for ZCCHC11 Gene

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