Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ZCCHC11 Gene

protein-coding   GIFtS: 53
GCID: GC01M052888

Zinc Finger, CCHC Domain Containing 11

  Search for ZCCHC11
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Zinc Finger, CCHC Domain Containing 111 2     TUTase41
Zinc Finger CCHC Domain-Containing Protein 112 3     PAPD32
TUT42 3     PAP Associated Domain Containing 32
TUTase 42 3     Terminal Uridylyltransferase 42
KIAA01913 5     EC 2.7.7.523

External Ids:    HGNC: 289811   Entrez Gene: 233182   Ensembl: ENSG000001347447   OMIM: 6136925   UniProtKB: Q5TAX33   

Export aliases for ZCCHC11 gene to outside databases

Previous GC identifers: GC01M052259 GC01M052601 GC01M052661 GC01M051004


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ZCCHC11 Gene:
ZCCHC11 is an RNA uridyltransferase (EC 2.7.7.52) that uses UTP to add uridines to the 3-prime end of substrate
RNA molecules (Jones et al., 2009 (PubMed 19701194)).(supplied by OMIM, Jan 2011)

GeneCards Summary for ZCCHC11 Gene:
ZCCHC11 (zinc finger, CCHC domain containing 11) is a protein-coding gene. GO annotations related to this gene include RNA uridylyltransferase activity and nucleic acid binding. An important paralog of this gene is TUT1.

UniProtKB/Swiss-Prot: TUT4_HUMAN, Q5TAX3
Function: Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating
the terminal uridylation of some miRNAs. Catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA
precursor. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of
pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain
pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and
LIN28B. Also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate
IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced
NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZCCHC11 gene promoter:
         AhR   TBP   Spz1   MAZR   Nkx2-2   Olf-1   C/EBPalpha   Arnt   S8   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZCCHC11 promoter sequence
   Search Chromatin IP Primers for ZCCHC11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZCCHC11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.3   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32.3

ZCCHC11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZCCHC11 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M052888:  view genomic region     (about GC identifiers)

Start:
52,873,954 bp from pter      End:
53,019,159 bp from pter
Size:
145,206 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TUT4_HUMAN, Q5TAX3 (See protein sequence)
Recommended Name: Terminal uridylyltransferase 4  
Size: 1644 amino acids; 185166 Da
Cofactor: Magnesium or manganese (By similarity)
Subunit: Interacts with LIN28A, LIN28B and T2BP
Sequence caution: Sequence=CAI23477.1; Type=Erroneous gene model prediction;
Secondary accessions: A2RRP0 B7Z8J5 D3DQ35 Q12764 Q5TAX2 Q5TAX4 Q86XZ3
Alternative splicing: 2 isoforms:  Q5TAX3-1   Q5TAX3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZCCHC11: NX_Q5TAX3

Explore proteomics data for ZCCHC11 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys680, Lys1000, Lys1036, Lys1260
  • Modification sites at PhosphoSitePlus

  • See ZCCHC11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001009881.1  NP_056084.1  

    ENSEMBL proteins: 
     ENSP00000432475   ENSP00000436810   ENSP00000257177   ENSP00000360599   ENSP00000437091  
     ENSP00000434674   ENSP00000435700   ENSP00000433711   ENSP00000433486   ENSP00000435256  
     ENSP00000432328   ENSP00000348063   ENSP00000434367   ENSP00000435568  

    ZCCHC11 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ZCCHC11
    GenScript Custom Purified and Recombinant Proteins Services for ZCCHC11
    Novus Biologicals ZCCHC11 Protein
    Novus Biologicals ZCCHC11 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZCCHC11

    ZCCHC11 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ZCCHC11
    Novus Biologicals ZCCHC11 Antibodies
    Abcam antibodies for ZCCHC11
    Cloud-Clone Corp. Antibodies for ZCCHC11
    ThermoFisher Antibodies for ZCCHC11
    LSBio Antibodies in human, mouse, rat for ZCCHC11

    ZCCHC11 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ZCCHC11
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ZCCHC11
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ZCCHC11
    Cloud-Clone Corp. CLIAs for ZCCHC11


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ZCCHC: Zinc fingers, CCHC domain containing

    3 InterPro protein domains:
     IPR002934 Nucleotidyltransferase
     IPR002058 PAP_assoc
     IPR001878 Znf_CCHC

    Graphical View of Domain Structure for InterPro Entry Q5TAX3

    ProtoNet protein and cluster: Q5TAX3

    2 Blocks protein domains:
    IPB002058 PAP/25A-associated domain
    IPB002934 DNA polymerase


    UniProtKB/Swiss-Prot: TUT4_HUMAN, Q5TAX3
    Similarity: Belongs to the DNA polymerase type-B-like family
    Similarity: Contains 3 CCHC-type zinc fingers
    Similarity: Contains 2 PAP-associated domains


    ZCCHC11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TUT4_HUMAN, Q5TAX3
    Function: Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating
    the terminal uridylation of some miRNAs. Catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA
    precursor. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of
    pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain
    pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and
    LIN28B. Also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate
    IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced
    NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation
    Catalytic activity: UTP + RNA(n) = diphosphate + RNA(n+1)

         Enzyme Number (IUBMB): EC 2.7.7.521

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0005515protein binding IPI16643855
    GO:0008270zinc ion binding IEA--
    GO:0016779nucleotidyltransferase activity ----
    GO:0044822poly(A) RNA binding IDA--
         
    ZCCHC11 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Zcchc11):
     cellular  growth/size/body  homeostasis/metabolism  mortality/aging 

    ZCCHC11 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZCCHC11
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZCCHC11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZCCHC11
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZCCHC11

    miRNA
    Products:
        
    miRTarBase miRNAs that target ZCCHC11:
    hsa-let-7b-5p (MIRT052322), hsa-mir-196a-5p (MIRT048241)

    Block miRNA regulation of human, mouse, rat ZCCHC11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZCCHC11 (see all 19):
    hsa-miR-142-5p hsa-miR-3607-3p hsa-miR-1271 hsa-miR-340 hsa-miR-132 hsa-miR-3923 hsa-miR-548x hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidZCCHC11 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ZCCHC11
    Predesigned siRNA for gene silencing in human, mouse, rat ZCCHC11

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ZCCHC11

    Clone
    Products:
         
    OriGene clones in human, mouse for ZCCHC11 (see all 15)
    OriGene ORF clones in mouse, rat for ZCCHC11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ZCCHC11 (NM_015269)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZCCHC11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZCCHC11

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ZCCHC11
    Browse ESI BIO Cell Lines and PureStem Progenitors for ZCCHC11 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCCHC11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TUT4_HUMAN, Q5TAX3: Nucleus. Cytoplasm. Note=Translocates into the cytoplasm following treatment of the cell
    with LPS
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005634nucleus ----
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0070062extracellular vesicular exosome IDA19056867

    ZCCHC11 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZCCHC11
    Interactions:

        Search GeneGlobe Interaction Network for ZCCHC11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ZCCHC11 (Q5TAX31, 3 ENSP000002571774) via UniProtKB, MINT, STRING, and/or I2D (see all 89)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LIN28AQ9H9Z23, ENSP000002542314I2D: score=1 STRING: ENSP00000254231
    LIN28BQ6ZN173, ENSP000003444014I2D: score=1 STRING: ENSP00000344401
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    TIFAQ96CG31, ENSP000003549114EBI-1606425,EBI-740711 STRING: ENSP00000354911
    AMBRA1Q9C0C73I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001816cytokine production IEA--
    GO:0010586miRNA metabolic process ISS--
    GO:0010587miRNA catabolic process IMP19703396
    GO:0019827stem cell maintenance IMP19703396
    GO:0031054pre-miRNA processing IMP19703396

    ZCCHC11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZCCHC11 (TUT4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ZCCHC11 gene (3 alternative transcripts): 
    NM_001009882.1  NM_001009881.2  NM_015269.2  

    Unigene Cluster for ZCCHC11:

    Zinc finger, CCHC domain containing 11
    Hs.655407  [show with all ESTs]
    Unigene Representative Sequence: NM_001009881
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000528457 ENST00000527941 ENST00000257177 ENST00000371544(uc001cty.2 uc001ctx.2 uc001cuc.2 uc009vze.1 uc009vzf.1)
    ENST00000466440 ENST00000494469 ENST00000471623 ENST00000531722 ENST00000474453
    ENST00000470212 ENST00000469810 ENST00000528642 ENST00000497120 ENST00000484723
    ENST00000481528 ENST00000371541(uc001cub.3) ENST00000481133 ENST00000473856

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZCCHC11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZCCHC11 (see all 19):
    hsa-miR-142-5p hsa-miR-3607-3p hsa-miR-1271 hsa-miR-340 hsa-miR-132 hsa-miR-3923 hsa-miR-548x hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidZCCHC11 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZCCHC11
    Predesigned siRNA for gene silencing in human, mouse, rat ZCCHC11
    Clone
    Products:
         
    OriGene clones in human, mouse for ZCCHC11 (see all 15)
    OriGene ORF clones in mouse, rat for ZCCHC11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ZCCHC11 (NM_015269)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZCCHC11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZCCHC11
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ZCCHC11
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZCCHC11
      QuantiTect SYBR Green Assays in human, mouse, rat ZCCHC11
      QuantiFast Probe-based Assays in human, mouse, rat ZCCHC11

    Additional mRNA sequence: 

    AK025698.1 AK095733.1 AK307579.1 AK308427.1 BC012047.1 BC018753.1 BC035820.1 BC131734.1 
    D83776.1 

    15 DOTS entries:

    DT.452033  DT.75146298  DT.101983756  DT.100833179  DT.101983757  DT.121437962  DT.92428730  DT.100718308 
    DT.121438013  DT.121438023  DT.91994395  DT.92056723  DT.95261567  DT.40269555  DT.91730437 

    Selected AceView cDNA sequences (see all 160):

    BX439159 BG536205 BX441611 CB132120 CR616727 CA449372 AL045167 BC048301 
    AK025698 AA894676 BM450281 F10702 AI872767 BU178489 AV714171 AU133635 
    BG942947 F13102 AA431368 BC018753 CR604717 AV709185 CB218481 AK095733 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC11 (see all 14)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^
    SP1:                                                                                                                          -                 -               
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                            -                                                               

    ExUns: 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b · 29c · 29d ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35a · 35b · 35c · 35d
    SP1:                                                                                            -                                                   
    SP2:                                                                                            -                                                   
    SP3:                                                              -                             -                                                   
    SP4:                                                                                            -                             -                     
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for ZCCHC11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ZCCHC11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGATTCAGA
    ZCCHC11 Expression
    About this image


    ZCCHC11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)
             Cerebral Cortex
    ZCCHC11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZCCHC11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655407
        Custom PCR Arrays for ZCCHC11
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ZCCHC11
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZCCHC11
    QuantiTect SYBR Green Assays in human, mouse, rat ZCCHC11
    QuantiFast Probe-based Assays in human, mouse, rat ZCCHC11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCCHC11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ZCCHC11 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zcchc111 , 5 zinc finger, CCHC domain containing 111, 5 89.11(n)1
    89.01(a)1
      4 (50.55 cM)5
    2305941  NM_175472.31  NP_780681.21 
     1084594265 
    chicken
    (Gallus gallus)
    Aves ZCCHC111 zinc finger, CCHC domain containing 11 73.79(n)
    70.58(a)
      424642  XM_422476.4  XP_422476.4 
    lizard
    (Anolis carolinensis)
    Reptilia ZCCHC116
    zinc finger, CCHC domain containing 11
    62(a)
    1 ↔ 1
    4(114583567-114623394)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.157972 Transcribed sequence with weak similarity to protein more 77.04(n)    142022457 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.178572 Transcribed sequence with weak similarity to protein more 73.71(n)    AL917696.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mkg-p6
    monkey king protein
    15(a)
    many ↔ many
    3L(8395268-8398377)
    worm
    (Caenorhabditis elegans)
    Secernentea pup-26
    cid-16
    (see all 3)
    Protein CID-1 (cid-1) mRNA, complete cds
    (see all 3)
    26(a)
    20(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    III(5185920-5188647) WBGene00019628
    III(5173945-5180510) WBGene00019629


    ENSEMBL Gene Tree for ZCCHC11 (if available)
    TreeFam Gene Tree for ZCCHC11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ZCCHC11 gene
    TUT12  ZCCHC62  MTPAP2  PAPD42  
    1 SIMAP similar gene for ZCCHC11 using alignment to 12 protein entries:     TUT4_HUMAN (see all proteins):
    ZCCHC6

    ZCCHC11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ZCCHC11 (see all 2514)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1469455001,2
    Cuntested152991935(+) TTTAAA/GGTTTT 4 T syn10--------
    rs1135555141,2
    C,F--52888531(+) ACAGAG/CGTTGC 2 -- int12Minor allele frequency- C:0.04NA 122
    rs3704305601,2
    C--52888593(+) TATCT-/AAAAAA 2 -- int10--------
    rs1442162811,2
    --52888808(+) GTGAAC/TATCCA 2 -- int10--------
    rs75529601,2
    C,F,A,H--52888836(+) AAATGT/ATACTT 2 -- int111Minor allele frequency- A:0.19NA NS EA WA CSA 795
    rs1914888921,2
    --52888876(+) GAATGC/TTCTAT 2 -- int10--------
    rs1841514961,2
    --52888881(+) CTCTAC/TTCACT 2 -- int10--------
    rs412945081,2
    C,F--52888909(+) TGTTAC/TGTAAT 2 -- int13Minor allele frequency- T:0.07WA NA 240
    rs8350311,2
    C,H--52888937(-) GTTAAT/ACTGTT 2 -- int117Minor allele frequency- A:0.01NS EA NA WA CSA 789
    rs770716391,2
    C,F--52889168(+) ACATGA/GAATTC 2 -- ut311Minor allele frequency- G:0.02NA 120

    HapMap Linkage Disequilibrium report for ZCCHC11 (52873954 - 53019159 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZCCHC11:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv988243CNV Insertion20482838

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZCCHC11
    DNA2.0 Custom Variant and Variant Library Synthesis for ZCCHC11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 613692    OMIM disorders: --


    ZCCHC11 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZCCHC11
    Human Genome Epidemiology (HuGE) Navigator: ZCCHC11 (4 documents)

    Export disorders for ZCCHC11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ZCCHC11 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with ZCCHC11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8724849)1, 2, 3 Nagase T.... Nomura N. (DNA Res. 1996)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. TUT4 in concert with Lin28 suppresses MicroRNA biogenesis through pre-microRNA uridylation. (PubMed id 19703396)1, 2 Heo I.... Kim V.N. (Cell 2009)
    5. Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'. (PubMed id 18172165)1, 2 Mullen T.E. and Marzluff W.F. (Genes Dev. 2008)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling. (PubMed id 16643855)1, 2 Minoda Y.... Yoshimura A. (Biochem. Biophys. Res. Commun. 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Gene regulation: reviving the message. (PubMed id 12239557)1, 3 Keller W. and Martin G. (Nature 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 23318 HGNC: 28981 AceView: ZCCHC11 Ensembl:ENSG00000134744 euGenes: HUgn23318
    ECgene: ZCCHC11 H-InvDB: ZCCHC11

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0191

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ZCCHC11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ZCCHC11 gene:
    Search GeneIP for patents involving ZCCHC11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ZCCHC11  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ZCCHC11  
     OriGene qSTAR qPCR primer pairs in human, mouse for ZCCHC11   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ZCCHC11   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ZCCHC11   OriGene Custom Protein Services for ZCCHC11  

     
     
     Block miRNA regulation of human, mouse, rat ZCCHC11 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ZCCHC11
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZCCHC11 Predesigned siRNA for gene silencing in human, mouse, rat ZCCHC11
     QuantiFast Probe-based Assays in human, mouse, rat ZCCHC11 QuantiTect SYBR Green Assays in human, mouse, rat ZCCHC11
     Custom PCR Arrays for ZCCHC11 Search Chromatin IP Primers for ZCCHC11
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZCCHC11  Search GeneGlobe Interaction Network for ZCCHC11
     Regulatory tfbs in ZCCHC11 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ZCCHC11 GenScript cDNA clones with any tag delivered in your preferred vector for ZCCHC11
     GenScript Custom Assay Services for ZCCHC11 GenScript Custom overexpressing Cell Line Services for ZCCHC11
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ZCCHC11 (TUT4)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ZCCHC11 antibodies
     ZCCHC11 proteins
     ZCCHC11 lysates
     Antibodies for ZCCHC11
     See all of Abcam's Antibodies, Kits and Proteins for ZCCHC11
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ZCCHC11
     Antibodies for ZCCHC11
     ELISAs for ZCCHC11
     CLIAs for ZCCHC11



     Browse ESI BIO Cell Lines and PureStem Progenitors for ZCCHC11
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCCHC11
     SwitchGear 3'UTR luciferase reporter plasmids for ZCCHC11
     SwitchGear Promoter luciferase reporter plasmids for ZCCHC11
     ThermoFisher Antibodies for ZCCHC11
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZCCHC11
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZCCHC11
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZCCHC11
     LSBio Antibodies in human, mouse, rat for ZCCHC11
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ZCCHC11 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4