Aliases for ZCCHC11 Gene
External Ids for ZCCHC11 Gene
ZCCHC11 is an RNA uridyltransferase (EC 22.214.171.124) that uses UTP to add uridines to the 3-prime end of substrate RNA molecules (Jones et al., 2009 [PubMed 19701194]).[supplied by OMIM, Jan 2011]
GeneCards Summary for ZCCHC11 Gene
ZCCHC11 (Zinc Finger, CCHC Domain Containing 11) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA uridylyltransferase activity. An important paralog of this gene is TUT1.
UniProtKB/Swiss-Prot for ZCCHC11 Gene
Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3 uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B. Also catalyzes the 3 uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation.