Aliases for ZCCHC11 Gene
External Ids for ZCCHC11 Gene
Previous GeneCards Identifiers for ZCCHC11 Gene
ZCCHC11 is an RNA uridyltransferase (EC 220.127.116.11) that uses UTP to add uridines to the 3-prime end of substrate RNA molecules (Jones et al., 2009 [PubMed 19701194]).[supplied by OMIM, Jan 2011]
GeneCards Summary for ZCCHC11 Gene
ZCCHC11 (Zinc Finger CCHC-Type Containing 11) is a Protein Coding gene. Diseases associated with ZCCHC11 include Perlman Syndrome. GO annotations related to this gene include nucleic acid binding and nucleotidyltransferase activity. An important paralog of this gene is TUT1.
UniProtKB/Swiss-Prot for ZCCHC11 Gene
Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:25480299). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency (By similarity). Does not bind RNA directly, but recruited to RNA targets by RNA-binding protein LIN28A. Also catalyzes the 3 uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression (By similarity). May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation. Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult.