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Aliases for ZCCHC10 Gene

Aliases for ZCCHC10 Gene

  • Zinc Finger CCHC-Type Containing 10 2 3 5

External Ids for ZCCHC10 Gene

Previous GeneCards Identifiers for ZCCHC10 Gene

  • GC05M132409
  • GC05M132360
  • GC05M132332
  • GC05M127524

Summaries for ZCCHC10 Gene

GeneCards Summary for ZCCHC10 Gene

ZCCHC10 (Zinc Finger CCHC-Type Containing 10) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.

Additional gene information for ZCCHC10 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCCHC10 Gene

Genomics for ZCCHC10 Gene

GeneHancer (GH) Regulatory Elements for ZCCHC10 Gene

Promoters and enhancers for ZCCHC10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I133025 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.0 32 2.5 PKNOX1 SMAD1 FOXA2 ARID4B SIN3A DMAP1 IRF4 YY1 POLR2B ZNF766 ZCCHC10 HSPA4 ENSG00000248648
GH05I134002 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 21.2 -977.9 -977872 4.9 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF213 ZNF143 VDAC1 ENSG00000271737 GC05P134006 DDX46 ZCCHC10 C5orf15
GH05I132292 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.8 +731.6 731597 5.2 PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC22A4 P4HA2 RAD50 AFF4 MIR3936HG IL4 FNIP1 ENSG00000202533 MIR3936 SLC22A5
GH05I132829 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 12.2 +196.2 196244 2.4 ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 ZNF207 ZNF143 SP3 SP5 SHROOM1 AFF4 RAD50 IL4 ENSG00000224431 ZCCHC10 ENSG00000248648 SLC22A4 ENSG00000272203
GH05I132961 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.3 +63.6 63649 3.6 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 SP3 ZNF610 AFF4 GC05M132963 LOC105379177 ENSG00000272023 IL4 RAD50 ENSG00000224431 ZCCHC10 HSPA4 GDF9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZCCHC10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZCCHC10 gene promoter:

Genomic Locations for ZCCHC10 Gene

Genomic Locations for ZCCHC10 Gene
chr5:132,996,985-133,026,617
(GRCh38/hg38)
Size:
29,633 bases
Orientation:
Minus strand
chr5:132,332,677-132,362,296
(GRCh37/hg19)

Genomic View for ZCCHC10 Gene

Genes around ZCCHC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZCCHC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZCCHC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCCHC10 Gene

Proteins for ZCCHC10 Gene

  • Protein details for ZCCHC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBK6-ZCH10_HUMAN
    Recommended name:
    Zinc finger CCHC domain-containing protein 10
    Protein Accession:
    Q8TBK6
    Secondary Accessions:
    • Q9NXR4

    Protein attributes for ZCCHC10 Gene

    Size:
    192 amino acids
    Molecular mass:
    20967 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZCCHC10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZCCHC10 Gene

Post-translational modifications for ZCCHC10 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZCCHC10 Gene

Domains & Families for ZCCHC10 Gene

Gene Families for ZCCHC10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZCCHC10 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZCCHC10: view

No data available for UniProtKB/Swiss-Prot for ZCCHC10 Gene

Function for ZCCHC10 Gene

Phenotypes From GWAS Catalog for ZCCHC10 Gene

Gene Ontology (GO) - Molecular Function for ZCCHC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZCCHC10: view
genes like me logo Genes that share phenotypes with ZCCHC10: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZCCHC10 Gene

Localization for ZCCHC10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZCCHC10 gene
Compartment Confidence
nucleus 4
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZCCHC10 Gene

Pathways & Interactions for ZCCHC10 Gene

SuperPathways for ZCCHC10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZCCHC10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZCCHC10 Gene

Drugs & Compounds for ZCCHC10 Gene

No Compound Related Data Available

Transcripts for ZCCHC10 Gene

Unigene Clusters for ZCCHC10 Gene

Zinc finger, CCHC domain containing 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - - -
SP8: - - - -
SP9: - - - - - - -
SP10:

Relevant External Links for ZCCHC10 Gene

GeneLoc Exon Structure for
ZCCHC10
ECgene alternative splicing isoforms for
ZCCHC10

Expression for ZCCHC10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZCCHC10 Gene

Protein differential expression in normal tissues from HIPED for ZCCHC10 Gene

This gene is overexpressed in Plasma (32.8) and CD8 Tcells (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZCCHC10 Gene



Protein tissue co-expression partners for ZCCHC10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZCCHC10 Gene:

ZCCHC10

SOURCE GeneReport for Unigene cluster for ZCCHC10 Gene:

Hs.29700

Evidence on tissue expression from TISSUES for ZCCHC10 Gene

  • Nervous system(4.3)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with ZCCHC10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZCCHC10 Gene

Orthologs for ZCCHC10 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZCCHC10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZCCHC10 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZCCHC10 34
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 96 (a)
OneToMany
-- 34
  • 72 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ZCCHC10 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zcchc10 34
  • 81 (a)
OneToMany
Gm6214 34
  • 60 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ZCCHC10 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZCCHC10 34
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZCCHC10 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6376 33
zebrafish
(Danio rerio)
Actinopterygii zcchc10 34
  • 72 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5516 34
  • 35 (a)
OneToOne
Species where no ortholog for ZCCHC10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZCCHC10 Gene

ENSEMBL:
Gene Tree for ZCCHC10 (if available)
TreeFam:
Gene Tree for ZCCHC10 (if available)

Paralogs for ZCCHC10 Gene

(7) SIMAP similar genes for ZCCHC10 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for ZCCHC10 Gene

genes like me logo Genes that share paralogs with ZCCHC10: view

No data available for Paralogs for ZCCHC10 Gene

Variants for ZCCHC10 Gene

Sequence variations from dbSNP and Humsavar for ZCCHC10 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000072463 -- 133,010,699(-) G/A intron_variant
rs1000123952 -- 132,998,181(-) AACA/ 3_prime_UTR_variant, non_coding_transcript_variant
rs1000278132 -- 133,007,409(-) G/A intron_variant
rs1000372793 -- 133,004,652(-) C/A intron_variant
rs1000441185 -- 133,000,855(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZCCHC10 Gene

Variant ID Type Subtype PubMed ID
nsv1022039 CNV gain 25217958
nsv1073495 CNV deletion 25765185
nsv1117581 CNV deletion 24896259
nsv1131915 CNV deletion 24896259
nsv1131916 CNV deletion 24896259
nsv1135956 CNV deletion 24896259
nsv830489 CNV loss 17160897
nsv830490 CNV gain 17160897
nsv968988 CNV duplication 23825009
nsv980725 CNV duplication 23825009

Variation tolerance for ZCCHC10 Gene

Residual Variation Intolerance Score: 34.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.57; 12.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZCCHC10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZCCHC10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZCCHC10 Gene

Disorders for ZCCHC10 Gene

Additional Disease Information for ZCCHC10

No disorders were found for ZCCHC10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZCCHC10 Gene

Publications for ZCCHC10 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for ZCCHC10 Gene

Sources for ZCCHC10 Gene

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