Aliases for ZCCHC10 Gene
External Ids for ZCCHC10 Gene
- HGNC: 25954
- Entrez Gene: 54819
- Ensembl: ENSG00000155329
- UniProtKB: Q8TBK6
Previous GeneCards Identifiers for ZCCHC10 Gene
- GC05M132409
- GC05M132360
- GC05M132332
- GC05M127524
Summaries for ZCCHC10 Gene
GeneCards Summary for ZCCHC10 Gene
ZCCHC10 (Zinc Finger CCHC-Type Containing 10) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding.
No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCCHC10 Gene
Genomics for ZCCHC10 Gene
Regulatory Elements for ZCCHC10 Gene
Enhancers for ZCCHC10 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ZCCHC10 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ZCCHC10 gene promoter:
Regulatory Element Products
Genomic Location for ZCCHC10 Gene
- Chromosome:
- 5
- Start:
- 132,996,985 bp from pter
- End:
- 133,026,617 bp from pter
- Size:
- 29,633 bases
- Orientation:
- Minus strand
Genomic View for ZCCHC10 Gene
Genes around ZCCHC10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q31.1 by Ensembl
- 5q31.1 by Entrez Gene
- 5q31.1 by HGNC
ZCCHC10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZCCHC10 Gene
Proteins for ZCCHC10 Gene
-
Protein details for ZCCHC10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TBK6-ZCH10_HUMAN
- Recommended name:
- Zinc finger CCHC domain-containing protein 10
- Protein Accession:
- Q8TBK6
- Q9NXR4
Protein attributes for ZCCHC10 Gene
- Size:
- 192 amino acids
- Molecular mass:
- 20967 Da
- Quaternary structure:
- No Data Available
Protein Expression for ZCCHC10 Gene
Post-translational modifications for ZCCHC10 Gene
Other Protein References for ZCCHC10 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ZCCHC10
- Invitrogen Antibodies for ZCCHC10
- GeneTex ZCCHC10 antibody for ZCCHC10
Protein Products
-
OriGene Purified Proteins for ZCCHC10
- Search Origene for MassSpec and Protein Over-expression Lysates for ZCCHC10
- Origene Custom Protein Services for ZCCHC10
- Search GeneTex for Proteins for ZCCHC10
Assay Products
No data available for DME Specific Peptides for ZCCHC10 Gene
Domains & Families for ZCCHC10 Gene
Gene Families for ZCCHC10 Gene
Protein Domains for ZCCHC10 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZCCHC10 Gene
Graphical View of Domain Structure for InterPro Entry
Q8TBK6- Similarity:
-
- Contains 1 CCHC-type zinc finger.
Function for ZCCHC10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ZCCHC10 Gene
- GenomeRNAi human phenotypes for ZCCHC10:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ZCCHC10
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ZCCHC10 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ZCCHC10 gene
- Search ViGene Biosciences for ZCCHC10
CRISPR Products
-
OriGene CRISPR knockouts for ZCCHC10
- GenScript: Design CRISPR guide RNA sequences for ZCCHC10
miRNA Products
- Search ViGene Biosciences for ZCCHC10
Inhibitory RNA Products
- Origene mouse_rna, siRNA, shRNA, and RNAi products in human, mouse, rat for ZCCHC10
- Browse OriGene Inhibitory RNA Products For ZCCHC10
-
ViGene Biosciences ready-to-package AAV shRNAs for ZCCHC10 gene
Clone Products
- Sino Biological Human cDNA Clone for ZCCHC10
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ZCCHC10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZCCHC10
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ZCCHC10
-
ViGene Biosciences adenoviral particle packaged cDNA for ZCCHC10 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ZCCHC10 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ZCCHC10 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZCCHC10 Gene
Localization for ZCCHC10 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| mitochondrion | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZCCHC10 Gene
Pathways & Interactions for ZCCHC10 Gene
No Data Available
Interacting Proteins for ZCCHC10 Gene
Selected Interacting proteins:
Q8TBK6-ZCH10_HUMAN
ENSP00000324274
for ZCCHC10 Gene via
MINT
STRING
UniProtKB
IID
No data available for Pathways by source and SIGNOR curated interactions for ZCCHC10 Gene
Transcripts for ZCCHC10 Gene
mRNA/cDNA for ZCCHC10 Gene
- (12) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (146) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ZCCHC10 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ZCCHC10
- GenScript: Design CRISPR guide RNA sequences for ZCCHC10
miRNA Products
- Search ViGene Biosciences for ZCCHC10
Inhibitory RNA Products
- Origene mouse_rna, siRNA, shRNA, and RNAi products in human, mouse, rat for ZCCHC10
- Browse OriGene Inhibitory RNA Products For ZCCHC10
-
ViGene Biosciences ready-to-package AAV shRNAs for ZCCHC10 gene
Clone Products
- Sino Biological Human cDNA Clone for ZCCHC10
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ZCCHC10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZCCHC10
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | |||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||
| SP7: | - | - | - | - | - | ||||||||||||||||||||||
| SP8: | - | - | - | - | |||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | ||||||||||||||||||||
| SP10: |
Expression for ZCCHC10 Gene
This gene is overexpressed in Plasma (32.8) and CD8 Tcells (12.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZCCHC10 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ZCCHC10 Gene:
ZCCHC10SOURCE GeneReport for Unigene cluster for ZCCHC10 Gene:
Hs.29700Primer Products
-
OriGene qPCR primer pairs and template standards for ZCCHC10
-
OriGene qPCR primer pairs for ZCCHC10
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZCCHC10 Gene
Orthologs for ZCCHC10 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | ZCCHC10 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ZCCHC10 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| chimpanzee (Pan troglodytes) |
Mammalia | ZCCHC10 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Zcchc10 35 |
|
OneToMany | |
| Gm6214 35 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | ZCCHC10 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ZCCHC10 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ZCCHC10 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.6376 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zcchc10 35 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG5516 35 |
|
OneToOne |
- Species where no ortholog for ZCCHC10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ZCCHC10 Gene
(7) SIMAP similar genes for ZCCHC10 Gene using alignment to 6 proteins:
Pseudogenes.org Pseudogenes for ZCCHC10 Gene
No data available for Paralogs for ZCCHC10 Gene
Variants for ZCCHC10 Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs10039686 | -- | 133,006,139(+) | gccac(C/T)atgcc | intron-variant | |
| rs10040499 | -- | 133,003,365(+) | TTCTA(A/C)ATGAA | intron-variant | |
| rs10045512 | -- | 133,003,263(+) | AAAGA(A/C)TAACC | intron-variant | |
| rs10052368 | -- | 133,004,363(+) | gagac(A/G)gggtt | intron-variant | |
| rs10053483 | -- | 133,023,222(+) | GAAGA(A/G)GGAGT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv980725 | CNV | duplication | 23825009 |
| nsv968988 | CNV | duplication | 23825009 |
| nsv830490 | CNV | gain | 17160897 |
| nsv830489 | CNV | loss | 17160897 |
| nsv1135956 | CNV | deletion | 24896259 |
| nsv1131916 | CNV | deletion | 24896259 |
| nsv1131915 | CNV | deletion | 24896259 |
| nsv1117581 | CNV | deletion | 24896259 |
| nsv1073495 | CNV | deletion | 25765185 |
| nsv1022039 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
34.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.57;
12.32% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ZCCHC10 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZCCHC10
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZCCHC10 Gene
Disorders for ZCCHC10 Gene
Relevant External Links for ZCCHC10
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- ZCCHC10
No disorders were found for ZCCHC10 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZCCHC10 Gene
Publications for ZCCHC10 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
Products for ZCCHC10 Gene
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- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Custom Assay Services
- OriGene Purified Proteins for ZCCHC10
- Search Origene for MassSpec and Protein Over-expression Lysates for ZCCHC10
- Origene Custom Protein Services for ZCCHC10
- Origene mouse_rna, siRNA, shRNA, and RNAi products in human, mouse, rat for ZCCHC10
- Browse OriGene Inhibitory RNA Products For ZCCHC10
- OriGene qPCR primer pairs and template standards for ZCCHC10
- OriGene qPCR primer pairs for ZCCHC10
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- Novus Biologicals Antibodies for ZCCHC10
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for ZCCHC10 gene
- ViGene Biosciences lentiviral particle packaged cDNA for ZCCHC10 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ZCCHC10 gene
- Search ViGene Biosciences for ZCCHC10
- Horizon Cell Lines for ZCCHC10
- Cyagen custom Knockout/knockin (KOKI) mouse models for ZCCHC10
- VectorBuilder custom plasmid, inducible vectors for ZCCHC10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZCCHC10
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ZCCHC10 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab