Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZCCHC10 Gene

Aliases for ZCCHC10 Gene

  • Zinc Finger CCHC-Type Containing 10 2 3 5

External Ids for ZCCHC10 Gene

Previous GeneCards Identifiers for ZCCHC10 Gene

  • GC05M132409
  • GC05M132360
  • GC05M132332
  • GC05M127524

Summaries for ZCCHC10 Gene

GeneCards Summary for ZCCHC10 Gene

ZCCHC10 (Zinc Finger CCHC-Type Containing 10) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding.

Additional gene information for ZCCHC10 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCCHC10 Gene

Genomics for ZCCHC10 Gene

Regulatory Elements for ZCCHC10 Gene

Enhancers for ZCCHC10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H132452 2 FANTOM5 Ensembl ENCODE dbSUPER 33.7 +559.4 559374 29 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B FEZF1 DMAP1 YY1 SLC30A9 AFF4 RAD50 ZCCHC10 IL4 IRF1 SLC22A5 ENSG00000224431 LOC102723741 MIR3936HG C5orf56
GH05H134002 1.4 ENCODE dbSUPER 21.2 -977.9 -977872 4 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF143 SP3 DDX46 ZCCHC10 ENSG00000271128 CTB-3M24.3 ENSG00000270892 VDAC1 GC05P134006 C5orf15
GH05H132667 1 ENCODE 25.7 +360.0 359987 0 HDGF ATF1 ARNT TCF12 ZNF766 CBX5 GATA2 ELK1 ATF7 CAVIN1 RAD50 AFF4 ZCCHC10 ENSG00000224431 IL4 ENSG00000248648 GC05M132664
GH05H132406 1.6 Ensembl ENCODE dbSUPER 15.4 +613.9 613881 11 HDGF FOXA2 PKNOX1 ARID4B SIN3A DMAP1 YBX1 YY1 ZNF143 ZNF207 RAD50 MIR3936HG ENSG00000224431 MIR3936 ZCCHC10 AFF4 P4HA2 RAPGEF6 ENSG00000202533 LOC105379175
GH05H132292 1.8 FANTOM5 ENCODE dbSUPER 10.8 +731.6 731598 5 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 RAD50 AFF4 MIR3936HG IL4 FNIP1 ENSG00000202533 MIR3936 SLC22A5 ENSG00000224431 ENSG00000248648
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZCCHC10 on UCSC Golden Path with GeneCards custom track

Promoters for ZCCHC10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000186923 217 1601 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 ZNF207 SP3

Genomic Location for ZCCHC10 Gene

Chromosome:
5
Start:
132,996,985 bp from pter
End:
133,026,617 bp from pter
Size:
29,633 bases
Orientation:
Minus strand

Genomic View for ZCCHC10 Gene

Genes around ZCCHC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZCCHC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZCCHC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCCHC10 Gene

Proteins for ZCCHC10 Gene

  • Protein details for ZCCHC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBK6-ZCH10_HUMAN
    Recommended name:
    Zinc finger CCHC domain-containing protein 10
    Protein Accession:
    Q8TBK6
    Secondary Accessions:
    • Q9NXR4

    Protein attributes for ZCCHC10 Gene

    Size:
    192 amino acids
    Molecular mass:
    20967 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZCCHC10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZCCHC10 Gene

Post-translational modifications for ZCCHC10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZCCHC10 Gene

Domains & Families for ZCCHC10 Gene

Gene Families for ZCCHC10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZCCHC10 Gene

Blocks:
InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZCCHC10: view

No data available for UniProtKB/Swiss-Prot for ZCCHC10 Gene

Function for ZCCHC10 Gene

Phenotypes From GWAS Catalog for ZCCHC10 Gene

Gene Ontology (GO) - Molecular Function for ZCCHC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZCCHC10: view
genes like me logo Genes that share phenotypes with ZCCHC10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZCCHC10 Gene

Localization for ZCCHC10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZCCHC10 gene
Compartment Confidence
nucleus 4
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZCCHC10 Gene

Pathways & Interactions for ZCCHC10 Gene

SuperPathways for ZCCHC10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZCCHC10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZCCHC10 Gene

Drugs & Compounds for ZCCHC10 Gene

No Compound Related Data Available

Transcripts for ZCCHC10 Gene

Unigene Clusters for ZCCHC10 Gene

Zinc finger, CCHC domain containing 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - - -
SP8: - - - -
SP9: - - - - - - -
SP10:

Relevant External Links for ZCCHC10 Gene

GeneLoc Exon Structure for
ZCCHC10
ECgene alternative splicing isoforms for
ZCCHC10

Expression for ZCCHC10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZCCHC10 Gene

Protein differential expression in normal tissues from HIPED for ZCCHC10 Gene

This gene is overexpressed in Plasma (32.8) and CD8 Tcells (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZCCHC10 Gene



Protein tissue co-expression partners for ZCCHC10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZCCHC10 Gene:

ZCCHC10

SOURCE GeneReport for Unigene cluster for ZCCHC10 Gene:

Hs.29700

Evidence on tissue expression from TISSUES for ZCCHC10 Gene

  • Nervous system(4.3)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with ZCCHC10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZCCHC10 Gene

Orthologs for ZCCHC10 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZCCHC10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZCCHC10 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZCCHC10 34
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 96 (a)
OneToMany
-- 34
  • 72 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ZCCHC10 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zcchc10 34
  • 81 (a)
OneToMany
Gm6214 34
  • 60 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ZCCHC10 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZCCHC10 34
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZCCHC10 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6376 33
zebrafish
(Danio rerio)
Actinopterygii zcchc10 34
  • 72 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5516 34
  • 35 (a)
OneToOne
Species where no ortholog for ZCCHC10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZCCHC10 Gene

ENSEMBL:
Gene Tree for ZCCHC10 (if available)
TreeFam:
Gene Tree for ZCCHC10 (if available)

Paralogs for ZCCHC10 Gene

(7) SIMAP similar genes for ZCCHC10 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for ZCCHC10 Gene

genes like me logo Genes that share paralogs with ZCCHC10: view

No data available for Paralogs for ZCCHC10 Gene

Variants for ZCCHC10 Gene

Sequence variations from dbSNP and Humsavar for ZCCHC10 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000072463 -- 133,010,699(+) TTCCT(A/G)AGCTC intron-variant
rs1000123952 -- 132,998,181(+) TACAT(-/AACA)TACAG nc-transcript-variant, utr-variant-3-prime
rs1000278132 -- 133,007,409(+) GTGGT(A/G)GTGGG intron-variant
rs1000372793 -- 133,004,652(+) CCCGG(A/C)TGATT intron-variant
rs1000441185 -- 133,000,855(+) CCAGG(C/G)TGGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZCCHC10 Gene

Variant ID Type Subtype PubMed ID
nsv1022039 CNV gain 25217958
nsv1073495 CNV deletion 25765185
nsv1117581 CNV deletion 24896259
nsv1131915 CNV deletion 24896259
nsv1131916 CNV deletion 24896259
nsv1135956 CNV deletion 24896259
nsv830489 CNV loss 17160897
nsv830490 CNV gain 17160897
nsv968988 CNV duplication 23825009
nsv980725 CNV duplication 23825009

Variation tolerance for ZCCHC10 Gene

Residual Variation Intolerance Score: 34.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.57; 12.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZCCHC10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZCCHC10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZCCHC10 Gene

Disorders for ZCCHC10 Gene

Relevant External Links for ZCCHC10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZCCHC10

No disorders were found for ZCCHC10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZCCHC10 Gene

Publications for ZCCHC10 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60

Products for ZCCHC10 Gene

Sources for ZCCHC10 Gene

Content
Loading form....