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ZCCHC10 Gene

protein-coding GIFtS: 49

GC05M132360

zinc finger, CCHC domain containing 10
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ20094 ^¹, ²

Descriptions
zinc finger, CCHC domain containing 10 ^²

External Ids
HGNC: 25954¹
Entrez Gene: 54819²
UniProtKB: Q8TBK6³
Ensembl: ENSG00000155329⁷

Search outside databases for aliases for ZCCHC10 gene

Previous GC identifer: GC05M132409

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ZCCHC10 gene

Entrez Gene cytogenetic band: 5q31.1 Ensembl cytogenetic band: 5q31.1 HGNC cytogenetic band: 5q31.1

ZCCHC10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M132360: (about GC identifiers)

Start:	132,360,576 bp from pter
End:	132,390,139 bp from pter
Size:	29,564 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000005.8 NT_034772.5

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ZCH10_HUMAN, Q8TBK6 (See protein sequence)

Recommended Name: Zinc finger CCHC domain-containing protein 10

Size: 192 amino acids; 20967 Da

Secondary accessions: Q9NXR4

Alternative splicing: 2 isoforms: Q8TBK6-1 Q8TBK6-2

REFSEQ proteins: NP_060135.1

ENSEMBL proteins:

ENSP00000324274 ENSP00000347533

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ZCCHC10)
	Human Recombinant Proteins from Abnova (ZCCHC10)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for ZCCHC10:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ZCCHC10), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ZCCHC10)
	Novus Biologicals Antibody for ZCCHC10

Assays for ZCCHC10:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8TBK6

ProtoNet protein and cluster: Q8TBK6

1 Blocks protein family: IPB001878 C2HC-type zinc-finger signature

UniProtKB/Swiss-Prot: ZCH10_HUMAN, Q8TBK6

Similarity: Contains 1 CCHC-type zinc finger

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZCCHC10)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_017665

Applied Biosystems Silencer® siRNAs for ZCCHC10

Sigma-Aldrich siRNA for ZCCHC10

Sigma-Aldrich shRNA for ZCCHC10

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ZCCHC10
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_017665
Myc/DDK tagged cDNA clone in CMV expression vector: NM_017665
untagged cDNA clone in CMV expression vector: NM_017665

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_017665

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/8 Interacting proteins for ZCCHC10 (Q8TBK6²) via UniProtKB, MINT, and/or STRING (see all 8 )
Interactant Interaction Details
GeneCard External ID(s)
DPPA2 Q7Z7J5² MINT-67758
LUC7L2 Q9Y383² MINT-65037
PIN1 Q13526² MINT-65035
PSME3 P61289² MINT-66551
STAC3 Q96MF2² MINT-67626
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZCCHC10

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZCCHC10)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_017665

Sigma-Aldrich siRNA for ZCCHC10

Sigma-Aldrich shRNA for ZCCHC10

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_017665

REFSEQ mRNAs for ZCCHC10 gene:

NM_017665.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_017665

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_017665
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_017665
                                 untagged cDNA clone in CMV expression vector: NM_017665

Additional cDNA sequence:

AF086446.1 AK000101.1 AK122970.1 AK300543.1 BC005211.1 BC015986.1 BC022443.1 CR598591.1

11 DOTS entries:

DT.211270 DT.100786399 DT.100786405 DT.100786407 DT.102828795 DT.100786401 DT.91766522 DT.91766517

DT.100786402 DT.120839787 DT.91952741

24/146 AceView cDNA sequences (see all 146 ):

AA393762 AK122970 AK000101 AU280137 AI368938 AA805344 AA708627 BU170057

AA456841 AW663425 AI243398 BU165290 AF086446 AA700745 BI256183 BG393119

NM_017665 BM835147 BC015986 AW663410 BU165539 W79536 AA862483 BF983215

highest scoring ESTs for ZCCHC10:

AA393932 AI480121 AK000101 AK122970 AL552764 AL553577 AL703301 AU252738 BC005211 BC015986

Unigene Cluster for ZCCHC10:

Zinc finger, CCHC domain containing 10

Hs.29700 [show with all ESTs]

Unigene Representative Sequence: AK122970

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC10 (see all 10 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7a	·	7b
SP1:											-				-		-		-
SP2:											-				-		-
SP3:															-		-		-
SP4:											-				-		-		-		-		-
SP5:									-		-				-		-		-

About this scheme

ECgene alternative splicing isoforms for ZCCHC10

2 Ensembl transcripts including schematic representations:

ENST00000324170 ENST00000355372

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ZCCHC10 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ZCCHC10

¹ / ² / ³

7 probe-sets matching ZCCHC10 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
44528_at²^{, 3}	U95-B	1	1.00	1.00	0.88	1.06	AI480121	0.80	1.00	0.91	1
60045_at²^{, 3}	U95-C	2	1.00	0.91	0.97	0.94	AA393932	0.80	1.00	0.91	1
221193_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_017665	0.60	1.00	0.82	1
223803_s_at²^{, 3}	U133-B	2	1.00	0.86	--	--	BC005211	0.80	1.00	0.91	1
221193_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1559399_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
223803_s_at²	U133Plus2	2	1.00	0.86	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAAGATGTCA

SOURCE GeneReport for Unigene cluster: Hs.29700

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZCCHC10 gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ZCCHC10¹	--	zinc finger, CCHC domain containing 10	94.71(n) 97.06(a)	474679 XM_531905.2 XP_531905.2
chimpanzee (Pan troglodytes)	ZCCHC10¹	--	zinc finger, CCHC domain containing 10	99.19(n) 100(a)	462059 XM_001164904.1 XP_001164904.1
cow (Bos taurus)	ZCCHC10¹	--	zinc finger, CCHC domain containing 10	92.94(n) 97.06(a)	515542 NM_001038545.1 NP_001033634.1
rat (Rattus norvegicus)	Zcchc10¹	--	zinc finger, CCHC domain containing 10	84.73(n) 87.1(a)	360524 XM_346887.3 XP_346888.2
mouse (Mus musculus)	Zcchc10^{1, 5}	11 (28.50 cM)⁵	zinc finger, CCHC domain containing 10^{1, 5}	82.94(n)¹ 89.29(a)¹	67966¹ NM_026479.3¹ NP_080755.2¹ AA675321⁵ AK010803⁵ (see all 11)

About this table Species with no ortholog for ZCCHC10

ENSEMBL Gene Tree for ZCCHC10

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ZCCHC10 gene

PNN²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/179 NCBI SNPs in ZCCHC10 are shown (see all 179 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 28)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs3087646^1,2	A,C,F,H	132362151(-)	`TGGACT/CGATGG`	1	--	ut3¹ ese³		19	EA NS MN EU WA NA	2934
	rs11742909^1,2	A,C,F,H	132360543(+)	`AACTGA/GCATTA`	1	--	ng5¹		8	EU EA WA NA	714
--	rs3210524^1,2	A,C,F,O	132361409(-)	`CTTAAA/GTAGAA`	1	--	ut3¹ ese³		2	EA MN	1656
--	rs10520099^1,2	C,F,H	132360622(-)	`TTGCAT/CCACTT`	1	--	ut3¹ ese³		13	NS NA EU EA WA	846
--	rs4301228^1,2	A,C,F,H	132369469(+)	`ATAACG/TCTTGA`	1	--	int¹		7	EU EA WA NA	552
--	rs7725601^1,2	A,C,F,H	132372916(+)	`aaaaaC/Acaaaa`	1	--	int¹		4	EU EA WA	388
	rs10053483^1,2	A,C,F,H	132386813(+)	`GAAGAA/GGGAGT`	1	--	int¹ trp³		8	EU EA WA	838
	rs10056639^1,2	A,C,F,H	132370081(+)	`aatgaG/Ataagt`	1	--	int¹		4	EU EA WA	410
	rs10053494^1,2	A,C,F,H	132386864(+)	`AAATAA/GTGCCT`	1	--	int¹		8	EU EA WA	836
--	rs10045512^1,2	A,C,F,H	132366854(+)	`AAAGAC/ATAACC`	1	--	int¹		5	EU EA WA	582

About this table

HapMap Linkage Disequilibrium images for ZCCHC10 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

5 PubMed articles for ZCCHC10 gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)³ Stelzl U....Wanker E.E. (2005)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)³ Rual J.F....Vidal M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 54819	HGNC: 25954	AceView: ZCCHC10	Ensembl:ENSG00000155329	euGenes: HUgn54819
ECgene: ZCCHC10	H-InvDB: ZCCHC10

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for ZCCHC10
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ZCCHC10:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ZCCHC10-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ZCCHC10		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ZCCHC10		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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Antibodies for ZCCHC10

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ZCCHC10 Gene

protein-coding GIFtS: 49

Aliases &
Descriptions
for ZCCHC10

Summaries
for ZCCHC10

Genomic Location
for ZCCHC10

Proteins
for ZCCHC10

Protein Domains/
Families
for ZCCHC10

Gene Function
for ZCCHC10

Pathways & Interactions
for ZCCHC10

Drugs & Compounds
for ZCCHC10

Transcripts
for ZCCHC10

Expression
for ZCCHC10

Orthologs
for ZCCHC10

Paralogs
for ZCCHC10

SNPs/Variants
for ZCCHC10

Disorders & Mutations
for ZCCHC10

Medical News
for ZCCHC10

Publications
for ZCCHC10

Search for ZCCHC10

Genome Databases showing ZCCHC10

Other Databases showing ZCCHC10

Specialized Databases showing ZCCHC10

Licensable Technologies
for ZCCHC10

Services
for ZCCHC10

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ZCCHC10 Gene

protein-coding GIFtS: 49

Aliases & Descriptionsfor ZCCHC10

Summariesfor ZCCHC10

Genomic Locationfor ZCCHC10

Proteinsfor ZCCHC10

Protein Domains/Familiesfor ZCCHC10

Gene Functionfor ZCCHC10

Pathways & Interactionsfor ZCCHC10

Drugs & Compoundsfor ZCCHC10

Transcriptsfor ZCCHC10

Expression for ZCCHC10

Orthologsfor ZCCHC10

Paralogsfor ZCCHC10

SNPs/Variantsfor ZCCHC10

Disorders & Mutationsfor ZCCHC10

Medical Newsfor ZCCHC10

Publicationsfor ZCCHC10

Search for ZCCHC10

Genome Databases showing ZCCHC10

Other Databases showing ZCCHC10

Specialized Databases showing ZCCHC10

Licensable Technologiesfor ZCCHC10

Servicesfor ZCCHC10

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ZCCHC10

Summaries
for ZCCHC10

Genomic Location
for ZCCHC10

Proteins
for ZCCHC10

Protein Domains/
Families
for ZCCHC10

Gene Function
for ZCCHC10

Pathways & Interactions
for ZCCHC10

Drugs & Compounds
for ZCCHC10

Transcripts
for ZCCHC10

Expression
for ZCCHC10

Orthologs
for ZCCHC10

Paralogs
for ZCCHC10

SNPs/Variants
for ZCCHC10

Disorders & Mutations
for ZCCHC10

Medical News
for ZCCHC10

Publications
for ZCCHC10

Licensable Technologies
for ZCCHC10

Services
for ZCCHC10