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ZCCHC10 Gene

protein-coding   GIFtS: 45
GCID: GC05M132332

Zinc Finger, CCHC Domain Containing 10

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, CCHC Domain Containing 101 2
Zinc Finger CCHC Domain-Containing Protein 102

External Ids:    HGNC: 259541   Entrez Gene: 548192   Ensembl: ENSG000001553297   UniProtKB: Q8TBK63   

Export aliases for ZCCHC10 gene to outside databases

Previous GC identifers: GC05M132409 GC05M132360 GC05M127524


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZCCHC10 Gene:
ZCCHC10 (zinc finger, CCHC domain containing 10) is a protein-coding gene. GO annotations related to this gene include nucleic acid binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZCCHC10 gene promoter:
         CREB   AP-1   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZCCHC10 promoter sequence
   Search Chromatin IP Primers for ZCCHC10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZCCHC10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q31.1

ZCCHC10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZCCHC10 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M132332:  view genomic region     (about GC identifiers)

Start:
132,332,677 bp from pter      End:
132,362,296 bp from pter
Size:
29,620 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZCH10_HUMAN, Q8TBK6 (See protein sequence)
Recommended Name: Zinc finger CCHC domain-containing protein 10  
Size: 192 amino acids; 20967 Da
Secondary accessions: Q9NXR4
Alternative splicing: 2 isoforms:  Q8TBK6-1   Q8TBK6-2   

Explore the universe of human proteins at neXtProt for ZCCHC10: NX_Q8TBK6

Explore proteomics data for ZCCHC10 at MOPED


See ZCCHC10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_060135.1  
ENSEMBL proteins: 
 ENSP00000324274   ENSP00000347533   ENSP00000423276   ENSP00000427430   ENSP00000422111  
 ENSP00000421071   ENSP00000427359  

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antibodies-online proteins for ZCCHC10 (7 products) 

 
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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ZCCHC: Zinc fingers, CCHC domain containing

1 InterPro protein domain:
 IPR001878 Znf_CCHC

Graphical View of Domain Structure for InterPro Entry Q8TBK6

ProtoNet protein and cluster: Q8TBK6

1 Blocks protein domain: IPB001878 C2HC-type zinc-finger signature

UniProtKB/Swiss-Prot: ZCH10_HUMAN, Q8TBK6
Similarity: Contains 1 CCHC-type zinc finger


Find genes that share domains with ZCCHC10           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003676nucleic acid binding IEA--
GO:0008270zinc ion binding IEA--
     
Find genes that share ontologies with ZCCHC10           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for ZCCHC10:
 Increased gamma-H2AX phosphory 

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for ZCCHC10

miRNA
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Selected qRT-PCR Assays for microRNAs that regulate ZCCHC10 (see all 24):
hsa-miR-548j hsa-miR-30c hsa-miR-548i hsa-miR-30d hsa-miR-124 hsa-miR-30a hsa-miR-3658 hsa-miR-548d-5p
SwitchGear 3'UTR luciferase reporter plasmidZCCHC10 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat ZCCHC10

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GenScript: all cDNA clones in your preferred vector: ZCCHC10 (NM_017665)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZCCHC10

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
mitochondrion1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZCCHC10
Interactions:

    Search GeneGlobe Interaction Network for ZCCHC10

STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

Selected Interacting proteins for ZCCHC10 (Q8TBK62, 3 ENSP000003242744) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
InteractantInteraction Details
GeneCardExternal ID(s)
C7orf55-LUC7L2Q9Y3832, 3MINT-65037 I2D: score=5 
LUC7L2Q9Y3832, 3MINT-65037 I2D: score=5 
TP53P046372, 3MINT-65034 I2D: score=5 
DPPA2Q7Z7J52, 3MINT-67758 I2D: score=4 
STAC3Q96MF22, 3, ENSP000003292004MINT-67626 I2D: score=4 STRING: ENSP00000329200
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ZCCHC10 (ZCH10)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ZCCHC10 gene: 
NM_017665.1  

Unigene Cluster for ZCCHC10:

Zinc finger, CCHC domain containing 10
Hs.29700  [show with all ESTs]
Unigene Representative Sequence: AK122970
10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000324170(uc003kyg.3 uc011cxl.2) ENST00000355372(uc003kyh.3)
ENST00000509437 ENST00000513848 ENST00000513541 ENST00000508080 ENST00000509008
ENST00000506403 ENST00000511440 ENST00000504170(uc003kyi.3)
miRNA
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Selected qRT-PCR Assays for microRNAs that regulate ZCCHC10 (see all 24):
hsa-miR-548j hsa-miR-30c hsa-miR-548i hsa-miR-30d hsa-miR-124 hsa-miR-30a hsa-miR-3658 hsa-miR-548d-5p
SwitchGear 3'UTR luciferase reporter plasmidZCCHC10 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for ZCCHC10
Predesigned siRNA for gene silencing in human, mouse, rat ZCCHC10
Clone
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZCCHC10
Primer
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OriGene qPCR primer pairs and template standards for ZCCHC10
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZCCHC10
  QuantiTect SYBR Green Assays in human, mouse, rat ZCCHC10
  QuantiFast Probe-based Assays in human, mouse, rat ZCCHC10

Additional mRNA sequence: 

AF086446.1 AK000101.1 AK122970.1 AK300543.1 BC005211.1 BC015986.1 BC022443.1 

11 DOTS entries:

DT.211270  DT.100786399  DT.100786405  DT.100786407  DT.102828795  DT.100786401  DT.91766522  DT.91766517 
DT.100786402  DT.120839787  DT.91952741 

Selected AceView cDNA sequences (see all 146):

AA918827 AI368938 BU170057 BM800630 AA700745 AK000101 BC005211 BC022443 
CR598591 AU280137 AA862483 AW663425 AK122970 BX095107 BQ719788 BC015986 
BI256183 BU165539 AA805344 CB112418 BM835147 BU165290 AF086446 W79536 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC10 (see all 10)    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b
SP1:                                -           -     -     -                           
SP2:                                -           -     -                                 
SP3:                                            -     -     -                           
SP4:                                -           -     -     -     -     -               
SP5:                          -     -           -     -     -                           


ECgene alternative splicing isoforms for ZCCHC10

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZCCHC10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TAAGATGTCA
ZCCHC10 Expression
About this image

ZCCHC10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ZCCHC10 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.29700
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZCCHC10

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for ZCCHC10 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Zcchc105 zinc finger, CCHC domain containing 10   --   11 (31.92 cM) 53324679 
chicken
(Gallus gallus)
Aves ZCCHC106
zinc finger, CCHC domain containing 10
74(a)
1 ↔ 1
13(16513391-16523481)
lizard
(Anolis carolinensis)
Reptilia ZCCHC106
zinc finger, CCHC domain containing 10
84(a)
1 ↔ 1
2(127174699-127197136)
African clawed frog
(Xenopus laevis)
Amphibia BI477054.12   -- 75.94(n)    BI477054.1 
zebrafish
(Danio rerio)
Actinopterygii 570942742   -- 77.91(n)    57094274 
fruit fly
(Drosophila melanogaster)
Insecta CG55166
--
35(a)
1 ↔ 1
3R(11789589-11790483)


ENSEMBL Gene Tree for ZCCHC10 (if available)
TreeFam Gene Tree for ZCCHC10 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ZCCHC10 gene
7 SIMAP similar genes for ZCCHC10 using alignment to 6 protein entries:     ZCH10_HUMAN (see all proteins):
LRRC37A3    TMEM135    ZNF670    ZNF843    FAM138C    KIAA1651
DNAPTP3

Find genes that share paralogs with ZCCHC10           About GenesLikeMe


2 Pseudogenes.org Pseudogenes for ZCCHC10
PGOHUM00000237886 PGOHUM00000251299


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZCCHC10 (see all 672)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 5 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1387601921,2
--132332335(+) GACTAG/TAGGGG 1 -- int10--------
rs1852359121,2
--132332344(+) GGCACA/GTCACC 1 -- int10--------
rs1494065431,2
--132332550(+) CTCTCC/TGTACC 1 -- int10--------
rs117429091,2
C,F,A,H--132332644(+) AACTGA/GCATTA 1 -- int123Minor allele frequency- G:0.38NS EA NA WA CSA 2643
rs105200991,2
C,F,H--132332723(-) TTGCAT/CCACTT 1 -- ut31 ese391Minor allele frequency- C:0.01NS NA EA PA EU CA WA CSA 4784
rs556374041,2
C--132332781(+) TTACCC/TTTACA 1 -- ut310--------
rs1128073471,2
C,F--132332845(+) AAGTGG/ATAATA 1 -- ut311Minor allele frequency- A:0.50CSA 2
rs1481798261,2
--132332934(+) AATTAC/TAGGCT 1 -- ut310--------
rs1440738501,2
--132333009(+) TCTACG/TGCTTT 1 -- ut310--------
rs1897524791,2
--132333068(+) TTTAAA/CCCAAA 1 -- ut310--------

HapMap Linkage Disequilibrium report for ZCCHC10 (132332677 - 132362296 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for ZCCHC10:    About this table    
Variant IDTypeSubtypePubMed ID
nsv830489CNV Loss17160897
nsv830490CNV Gain17160897

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing ZCCHC10
DNA2.0 Custom Variant and Variant Library Synthesis for ZCCHC10

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ZCCHC10 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ZCCHC10)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  4. Dynamic protein-protein interaction wiring of the human spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (Mol. Cell 2012)
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
  6. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
  7. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 54819 HGNC: 25954 AceView: ZCCHC10 Ensembl:ENSG00000155329 euGenes: HUgn54819
ECgene: ZCCHC10 H-InvDB: ZCCHC10

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ZCCHC10 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ZCCHC10 gene:
Search GeneIP for patents involving ZCCHC10

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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