ZC4H2 Gene
protein-coding GIFtS: 47
GCID: GC0XM064136
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zinc finger, C4H2 domain containing(Previous name: KIAA1166 )
(Previous symbol: KIAA1166)
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Aliases
for ZC4H2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger, C4H2 Domain Containing1 2 | | HCA1271 2 3 | | KIAA11661 2 3 | | Hepatocellular Carcinoma-Associated Antigen 1272 3 | | Zinc Finger C4H2 Domain-Containing Protein2 |
Export aliases for ZC4H2 gene to outside databasesPrevious GC identifers: GC0XM064053 GC0XM057961 |
Summaries
for ZC4H2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZC4H2:
This gene encodes a member of the zinc finger domain-containing protein family. This family member has a C-terminalzinc finger domain that is characterized by four cysteine residues and two histidine residues, and it also includes acoiled-coil region. This protein has been detected as an autoantigen in hepatocellular carcinoma patients. This genehas been identified as a potential candidate for X-linked mental retardation. Alternative splicing results in multipletranscript variants. (provided by RefSeq, Aug 2011)
Gene Wiki entry for ZC4H2 (KIAA1166)
|
Genomic Views
for ZC4H2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011669.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZC4H2 gene promoter:
Pax-5 GCNF STAT5A Evi-1 SRY POU2F1 GCNF-1 POU2F1a GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZC4H2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZC4H2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq11.2 Ensembl cytogenetic band: Xq11.2 HGNC cytogenetic band: Xq11.1ZC4H2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM064136: view genomic region
(about GC identifiers)
Start:
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64,136,250 bp from pter |
End:
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64,254,593 bp from pter |
Size:
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118,344 bases |
Orientation:
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minus strand |
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Proteins
for ZC4H2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZC4H2_HUMAN, Q9NQZ6 (See
protein sequence)Recommended Name: Zinc finger C4H2 domain-containing protein Size: 224 amino acids; 26244 Da
Sequence caution: Sequence=BAA86480.1; Type=Erroneous initiation;
Secondary accessions: B2RDC2 B4DED0 E7EM74 Q5JTF9 Q9H9C3 Q9H9H7 Q9ULQ4Alternative splicing: 4 isoforms: Q9NQZ6-1 Q9NQZ6-2 Q9NQZ6-3 Q9NQZ6-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZC4H2: NX_Q9NQZ6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NQZ6
ZC4H2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001171503.1 NP_001171504.1 NP_001230733.1 NP_061154.1
ENSEMBL proteins: ENSP00000363972 ENSP00000338650 ENSP00000399126 ENSP00000440840
Human Recombinant Protein Products:
ZC4H2 Antibody Products:
Assay Products for ZC4H2: |
Protein
Domains /
Families
for ZC4H2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZC4H2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NQZ6ProtoNet protein and cluster: Q9NQZ6 UniProtKB/Swiss-Prot: ZC4H2_HUMAN, Q9NQZ6Similarity: Contains 1 C4H2-type zinc finger |
Function
for ZC4H2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZC4H2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZC4H2 (see all 3)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC4H2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0046872 | metal ion binding |
IEA | -- |
ZC4H2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZC4H2:
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Pathways & Interactions
for ZC4H2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZC4H2
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5 Interacting proteins for ZC4H2 (Q9NQZ62, 3 ENSP000003639724) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for ZC4H2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZC4H2
Search CenterWatch for drugs/clinical trials and news about ZC4H2
|
Transcripts
for ZC4H2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZC4H2 gene (4 alternative transcripts): NM_001178032.2 NM_001178033.2 NM_001243804.1 NM_018684.3 Unigene Cluster for ZC4H2: Zinc finger, C4H2 domain containing Hs.28249 [show with all ESTs]Unigene Representative Sequence: NR_0450449 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000374839(uc004dvu.3) ENST00000337990(uc022byc.1 uc004dvv.3 uc022byd.1)
ENST00000488608(uc004dvw.2) ENST00000488406 ENST00000492653 ENST00000488831
ENST00000476032 ENST00000447788(uc011mow.2) ENST00000545618(uc011mov.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZC4H2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZC4H2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): ZC4H2 (NM_018684) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZC4H2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZC4H2 |
Additional cDNA sequence: AF270491.1 AK001547.1 AK022807.1 AK022918.1 AK222708.1 AK293570.1 AK315485.1 BC004411.1 NR_045044.1 9 DOTS entries: DT.414856 DT.95180917 DT.91802205 DT.100781866 DT.121319612 DT.100781869 DT.121319621 DT.91751023 DT.121468853 24/127 AceView cDNA sequences (see all 127): AI264817 BM925514 AA807922 AI032600 AI084931 H21675 AI094284 AA341132 AI240809 BU501486 AA701257 AI379128 AL558772 AA724198 AU130102 AA722414 BQ070143 AA888146 BE271256 BQ446915 Z41408 AW511746 AI085233 AA195257
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ZC4H2 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b |
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| SP1: | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZC4H2
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Expression
for ZC4H2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZC4H2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ZC4H2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZC4H2
SOURCE GeneReport for Unigene cluster: Hs.28249
SABiosciences Custom PCR Arrays for ZC4H2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZC4H2
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC4H2 |
Orthologs
for ZC4H2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZC4H2 gene from 7/23 species (see all 23) About this table
ENSEMBL Gene Tree for ZC4H2 (if available)
TreeFam Gene Tree for ZC4H2 (if available) |
Paralogs
for ZC4H2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ZC4H2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZC4H2 (64136250 - 64254593 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZC4H2
1 CNV: 3251
Locus Specific Mutation Databases (LSDB): ZC4H2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZC4H2 |
|
Disorders
/ Diseases
for ZC4H2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZC4H2 for disorders About GeneDecksing
4  diseases for ZC4H2: About MalaCardshepatocellular carcinoma carcinoma prostate cancer prostatitis
Export disorders for ZC4H2 gene to outside databases
|
Publications
for ZC4H2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZC4H2 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with ZC4H2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Large scale identification of human hepatocellular carcinoma- associated antigens by autoantibodies. (PubMed id 12097419)1, 2, 3 Wang Y....Chen W.-F. (2002)
- Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2, 3 Hirosawa M.... Ohara O. (1999)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A computational approach to candidate gene prioritiza tion for X-linked mental retardation using annotation-based binary filtering an d motif-based linear discriminatory analysis. (PubMed id 21668950)1 Lombard Z....Ramsay M. (2011)
- Genome-wide association study to identify single nucl eotide polymorphisms (SNPs) associated with the development of erectile dysfunc tion in African-American men after radiotherapy for prostate cancer. (PubMed id 20932654)1 Kerns S.L....Rosenstein B.S. (2010)
- Zinc fingers as biologic redox switches? (PubMed id 19132878)1 KrAPncke K.D. and Klotz L.O. (2009)
- Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (2007)
- Sticky fingers: zinc-fingers as protein-recognition m otifs. (PubMed id 17210253)1 Gamsjaeger R....Mackay J.P. (2007)
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External Searches for ZC4H2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ZC4H2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZC4H2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ZC4H2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZC4H2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZC4H2 gene:
Search GeneIP for patents involving ZC4H2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZC4H2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZC4H2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZC4H2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZC4H2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZC4H2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZC4H2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZC4H2 |
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 | | | ZC4H2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC4H2 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZC4H2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZC4H2 |
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