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Aliases for ZC4H2 Gene

Aliases for ZC4H2 Gene

  • Zinc Finger, C4H2 Domain Containing 2 3
  • KIAA1166 2 3 4 6
  • Hepatocellular Carcinoma-Associated Antigen 127 3 4
  • HCA127 3 4
  • WRWF 3 6
  • Zinc Finger C4H2 Domain-Containing Protein 3
  • Wieacker-Wolff Syndrome 2
  • WWS 3

External Ids for ZC4H2 Gene

Previous HGNC Symbols for ZC4H2 Gene

  • KIAA1166
  • WWS

Previous GeneCards Identifiers for ZC4H2 Gene

  • GC0XM064053
  • GC0XM057961
  • GC0XM064136

Summaries for ZC4H2 Gene

Entrez Gene Summary for ZC4H2 Gene

  • This gene encodes a member of the zinc finger domain-containing protein family. This family member has a C-terminal zinc finger domain that is characterized by four cysteine residues and two histidine residues, and it also includes a coiled-coil region. This protein has been detected as an autoantigen in hepatocellular carcinoma patients. This gene has been identified as a potential candidate for X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for ZC4H2 Gene

ZC4H2 (Zinc Finger, C4H2 Domain Containing) is a Protein Coding gene. Diseases associated with ZC4H2 include wieacker-wolff syndrome and hepatocellular carcinoma.

UniProtKB/Swiss-Prot for ZC4H2 Gene

  • May play a role in neuronal development and in neuromuscular junction formation.

Gene Wiki entry for ZC4H2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC4H2 Gene

Genomics for ZC4H2 Gene

Regulatory Elements for ZC4H2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZC4H2 Gene

Start:
64,915,802 bp from pter
End:
65,034,744 bp from pter
Size:
118,943 bases
Orientation:
Minus strand

Genomic View for ZC4H2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZC4H2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC4H2 Gene

Proteins for ZC4H2 Gene

  • Protein details for ZC4H2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQZ6-ZC4H2_HUMAN
    Recommended name:
    Zinc finger C4H2 domain-containing protein
    Protein Accession:
    Q9NQZ6
    Secondary Accessions:
    • B2RDC2
    • B3KVZ5
    • B4DED0
    • E7EM74
    • G3V1L3
    • Q53H73
    • Q5JTF9
    • Q9H9C3
    • Q9H9H7
    • Q9ULQ4

    Protein attributes for ZC4H2 Gene

    Size:
    224 amino acids
    Molecular mass:
    26244 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA86480.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZC4H2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZC4H2 Gene

Proteomics data for ZC4H2 Gene at MOPED

Post-translational modifications for ZC4H2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZC4H2 Gene

No data available for DME Specific Peptides for ZC4H2 Gene

Domains for ZC4H2 Gene

Gene Families for ZC4H2 Gene

HGNC:

Protein Domains for ZC4H2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NQZ6

UniProtKB/Swiss-Prot:

ZC4H2_HUMAN :
  • Q9NQZ6
Similarity:
  • Contains 1 C4H2-type zinc finger.
genes like me logo Genes that share domains with ZC4H2: view

Function for ZC4H2 Gene

Molecular function for ZC4H2 Gene

UniProtKB/Swiss-Prot Function: May play a role in neuronal development and in neuromuscular junction formation.

Gene Ontology (GO) - Molecular Function for ZC4H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZC4H2: view

Phenotypes for ZC4H2 Gene

GenomeRNAi human phenotypes for ZC4H2:
genes like me logo Genes that share phenotypes with ZC4H2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZC4H2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZC4H2 Gene

Localization for ZC4H2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZC4H2 Gene

Cytoplasm. Nucleus. Cell junction, synapse, postsynaptic cell membrane. Note=Upon transfection into mouse primary hippocampal neurons, localizes at excitatory, but not inhibitory, postsynaptic sites.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZC4H2 Gene COMPARTMENTS Subcellular localization image for ZC4H2 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ZC4H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 23623388
GO:0005737 cytoplasm IDA 23623388
GO:0030054 cell junction IEA --
GO:0045211 postsynaptic membrane IDA 23623388
genes like me logo Genes that share ontologies with ZC4H2: view

Pathways for ZC4H2 Gene

SuperPathways for ZC4H2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZC4H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development IDA 23623388
GO:0007528 neuromuscular junction development ISS --
GO:0021522 spinal cord motor neuron differentiation ISS --
genes like me logo Genes that share ontologies with ZC4H2: view

No data available for Pathways by source for ZC4H2 Gene

Transcripts for ZC4H2 Gene

Unigene Clusters for ZC4H2 Gene

Zinc finger, C4H2 domain containing:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZC4H2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZC4H2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: - - - - -
SP2: - -
SP3: - -
SP4: -
SP5:

Relevant External Links for ZC4H2 Gene

GeneLoc Exon Structure for
ZC4H2
ECgene alternative splicing isoforms for
ZC4H2

Expression for ZC4H2 Gene

mRNA expression in normal human tissues for ZC4H2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZC4H2 Gene

SOURCE GeneReport for Unigene cluster for ZC4H2 Gene Hs.28249

mRNA Expression by UniProt/SwissProt for ZC4H2 Gene

Q9NQZ6-ZC4H2_HUMAN
Tissue specificity: Expressed in fetal tissues, including in brain, intestine, lung, kidney and muscle.
genes like me logo Genes that share expressions with ZC4H2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZC4H2 Gene

Orthologs for ZC4H2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZC4H2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZC4H2 35
  • 99.5 (n)
  • 100 (a)
ZC4H2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZC4H2 35
  • 94.05 (n)
  • 99.55 (a)
ZC4H2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZC4H2 35
  • 93.15 (n)
  • 100 (a)
ZC4H2 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zc4h2 35
  • 90.33 (n)
  • 100 (a)
Zc4h2 16
Zc4h2 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZC4H2 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZC4H2 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zc4h2 35
  • 90.03 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves ZC4H2 35
  • 82.14 (n)
  • 99.55 (a)
ZC4H2 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZC4H2 36
  • 98 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.22980 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.686 35
zc4h2 35
  • 81.99 (n)
  • 97.77 (a)
zebrafish
(Danio rerio)
Actinopterygii wufb99f08 35
zc4h2 35
  • 77.83 (n)
  • 94.2 (a)
zc4h2 36
  • 94 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010728 35
  • 56.49 (n)
  • 55.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13001 35
  • 63.17 (n)
  • 58.01 (a)
CG13001 36
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea vab-23 36
  • 28 (a)
OneToMany
ZK930.2 36
  • 24 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2141 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToOne
Species with no ortholog for ZC4H2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZC4H2 Gene

ENSEMBL:
Gene Tree for ZC4H2 (if available)
TreeFam:
Gene Tree for ZC4H2 (if available)

Paralogs for ZC4H2 Gene

No data available for Paralogs for ZC4H2 Gene

Variants for ZC4H2 Gene

Sequence variations from dbSNP and Humsavar for ZC4H2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs868425 -- 65,026,062(+) AGGGA(A/C)AGAGG intron-variant
rs945261 -- 65,025,463(-) ATTTA(A/G)ATAAC intron-variant
rs1335402 -- 64,966,830(-) AATTA(A/G)CTCTT intron-variant
rs1335403 -- 65,017,201(-) CACAA(A/G)GGGGA intron-variant
rs1335404 -- 65,017,125(-) TCTAA(A/G)GGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZC4H2 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354
dgv2449e1 CNV Complex 17122850
esv2663820 CNV Deletion 23128226
esv2675440 CNV Deletion 23128226

Relevant External Links for ZC4H2 Gene

HapMap Linkage Disequilibrium report
ZC4H2
Human Gene Mutation Database (HGMD)
ZC4H2
Locus Specific Mutation Databases (LSDB)
ZC4H2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC4H2 Gene

Disorders for ZC4H2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for ZC4H2 Gene including...

Search for ZC4H2 Gene in MalaCards »

(1) OMIM Diseases for ZC4H2 Gene (300897)

UniProtKB/Swiss-Prot

ZC4H2_HUMAN
  • Wieacker-Wolf syndrome (WRWF) [MIM:314580]: A severe X-linked recessive neurodevelopmental disorder affecting the central and peripheral nervous systems. It is characterized by onset of muscle weakness in utero (fetal akinesia). Affected boys are born with severe contractures, known as arthrogryposis, and have delayed motor development, facial and bulbar weakness, characteristic dysmorphic facial features, and skeletal abnormalities, such as hip dislocation, scoliosis, and pes equinovarus. Those that survive infancy show mental retardation. Carrier females may have mild features of the disorder. {ECO:0000269 PubMed:23623388}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ZC4H2

Genetic Association Database (GAD)
ZC4H2
genes like me logo Genes that share disorders with ZC4H2: view

Publications for ZC4H2 Gene

  1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 2 3 4
  2. Large scale identification of human hepatocellular carcinoma- associated antigens by autoantibodies. (PMID: 12097419) Wang Y. … Chen W.-F. (J. Immunol. 2002) 2 3 4
  3. ZC4H2 mutations are associated with arthrogryposis multiplex congenita and intellectual disability through impairment of central and peripheral synaptic plasticity. (PMID: 23623388) Hirata H. … Kalscheuer V.M. (Am. J. Hum. Genet. 2013) 2 3 4
  4. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. (PMID: 20932654) Kerns S.L. … Rosenstein B.S. (Int. J. Radiat. Oncol. Biol. Phys. 2010) 3 48
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for ZC4H2 Gene

Sources for ZC4H2 Gene

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