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ZC4H2 Gene

protein-coding   GIFtS: 50
GCID: GC0XM064136

Zinc Finger, C4H2 Domain Containing

(Previous names: KIAA1166, Wieacker-Wolff syndrome)
(Previous symbols: KIAA1166, WWS)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, C4H2 Domain Containing1 2     HCA1272 3
KIAA11661 2 3 5     WRWF2 5
WWS1 2     Wieacker-Wolff Syndrome1
Hepatocellular Carcinoma-Associated Antigen 1272 3     Zinc Finger C4H2 Domain-Containing Protein2

External Ids:    HGNC: 249311   Entrez Gene: 559062   Ensembl: ENSG000001269707   OMIM: 3008975   UniProtKB: Q9NQZ63   

Export aliases for ZC4H2 gene to outside databases

Previous GC identifers: GC0XM064053 GC0XM057961


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZC4H2 Gene:
This gene encodes a member of the zinc finger domain-containing protein family. This family member has a
C-terminal zinc finger domain that is characterized by four cysteine residues and two histidine residues, and it
also includes a coiled-coil region. This protein has been detected as an autoantigen in hepatocellular carcinoma
patients. This gene has been identified as a potential candidate for X-linked mental retardation. Alternative
splicing results in multiple transcript variants. (provided by RefSeq, Aug 2011)

GeneCards Summary for ZC4H2 Gene:
ZC4H2 (zinc finger, C4H2 domain containing) is a protein-coding gene. Diseases associated with ZC4H2 include wieacker-wolf syndrome, and hepatocellular carcinoma.

UniProtKB/Swiss-Prot: ZC4H2_HUMAN, Q9NQZ6
Function: May play a role in neuronal development and in neuromuscular junction formation

Gene Wiki entry for ZC4H2 (KIAA1166) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_011651.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZC4H2 gene promoter:
         Pax-5   GCNF   STAT5A   Evi-1   SRY   POU2F1   GCNF-1   POU2F1a   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZC4H2 promoter sequence
   Search Chromatin IP Primers for ZC4H2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZC4H2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq11.2   Ensembl cytogenetic band:  Xq11.2   HGNC cytogenetic band: Xq11.1

ZC4H2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZC4H2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM064136:  view genomic region     (about GC identifiers)

Start:
64,136,250 bp from pter      End:
64,254,593 bp from pter
Size:
118,344 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZC4H2_HUMAN, Q9NQZ6 (See protein sequence)
Recommended Name: Zinc finger C4H2 domain-containing protein  
Size: 224 amino acids; 26244 Da
Sequence caution: Sequence=BAA86480.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2RDC2 B3KVZ5 B4DED0 E7EM74 G3V1L3 Q53H73 Q5JTF9 Q9H9C3 Q9H9H7 Q9ULQ4
Alternative splicing: 5 isoforms:  Q9NQZ6-1   Q9NQZ6-2   Q9NQZ6-3   Q9NQZ6-4   Q9NQZ6-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZC4H2: NX_Q9NQZ6

Explore proteomics data for ZC4H2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZC4H2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001171503.1  NP_001171504.1  NP_001230733.1  NP_061154.1  

    ENSEMBL proteins: 
     ENSP00000363972   ENSP00000338650   ENSP00000399126   ENSP00000440840  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZC4H2: Zinc fingers

    1 InterPro protein domain:
     IPR018482 Znf-C4H2

    Graphical View of Domain Structure for InterPro Entry Q9NQZ6

    ProtoNet protein and cluster: Q9NQZ6

    UniProtKB/Swiss-Prot: ZC4H2_HUMAN, Q9NQZ6
    Similarity: Contains 1 C4H2-type zinc finger


    ZC4H2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZC4H2_HUMAN, Q9NQZ6
    Function: May play a role in neuronal development and in neuromuscular junction formation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--
         
    ZC4H2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZC4H2:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZC4H2
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    Selected qRT-PCR Assays for microRNAs that regulate ZC4H2 (see all 24):
    hsa-miR-29c hsa-miR-29a hsa-let-7a-2* hsa-miR-218 hsa-miR-3125 hsa-miR-3916 hsa-miR-3154 hsa-miR-2115
    SwitchGear 3'UTR luciferase reporter plasmidZC4H2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZC4H2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZC4H2_HUMAN, Q9NQZ6: Cytoplasm. Nucleus. Cell junction, synapse, postsynaptic cell membrane. Note=Upon
    transfection into mouse primary hippocampal neurons, localizes at excitatory, but not inhibitory, postsynaptic
    sites
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0030054cell junction IEA--
    GO:0045211postsynaptic membrane IDA--

    ZC4H2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZC4H2
    Interactions:

        Search GeneGlobe Interaction Network for ZC4H2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for ZC4H2 (Q9NQZ62, 3 ENSP000003639724) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KXD1Q9BQD32, 3, ENSP000002223074MINT-67175 I2D: score=4 STRING: ENSP00000222307
    PIK3R1P279863, ENSP000002743354I2D: score=2 STRING: ENSP00000274335
    BIRC5ENSP000003016334STRING: ENSP00000301633
    RNF220ENSP000003475484STRING: ENSP00000347548
    HIBCHENSP000003527064STRING: ENSP00000352706
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007399nervous system development IDA--
    GO:0007528neuromuscular junction development ISS--
    GO:0021522spinal cord motor neuron differentiation ISS--

    ZC4H2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZC4H2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZC4H2 gene (4 alternative transcripts): 
    NM_001178032.2  NM_001178033.2  NM_001243804.1  NM_018684.3  

    Unigene Cluster for ZC4H2:

    Zinc finger, C4H2 domain containing
    Hs.28249  [show with all ESTs]
    Unigene Representative Sequence: NR_045044
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374839(uc004dvu.3) ENST00000337990(uc022byc.1 uc004dvv.3 uc022byd.1)
    ENST00000488608(uc004dvw.2) ENST00000488406 ENST00000492653 ENST00000488831
    ENST00000476032 ENST00000447788(uc011mow.2) ENST00000545618(uc011mov.2)

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    Selected qRT-PCR Assays for microRNAs that regulate ZC4H2 (see all 24):
    hsa-miR-29c hsa-miR-29a hsa-let-7a-2* hsa-miR-218 hsa-miR-3125 hsa-miR-3916 hsa-miR-3154 hsa-miR-2115
    SwitchGear 3'UTR luciferase reporter plasmidZC4H2 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat ZC4H2
      QuantiFast Probe-based Assays in human, mouse, rat ZC4H2

    Additional mRNA sequence: 

    AF270491.1 AK001547.1 AK022807.1 AK022918.1 AK222708.1 AK293570.1 AK315485.1 BC004411.1 
    NR_045044.1 

    9 DOTS entries:

    DT.414856  DT.95180917  DT.91802205  DT.100781866  DT.121319612  DT.100781869  DT.121319621  DT.91751023 
    DT.121468853 

    Selected AceView cDNA sequences (see all 127):

    AW768291 Z41408 AI264817 AA807922 AI032600 BM925514 AA888146 AA341132 
    AI085233 AI094284 AA194077 BM676738 BQ070143 AK001547 AA195257 AI084931 
    AA722414 BQ446915 AL558772 AI240809 H21675 AW511746 AA701257 BU501486 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZC4H2    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b
    SP1:        -     -     -     -     -                                             
    SP2:                                -     -                                       
    SP3:                                -     -                                       
    SP4:                                -                                             
    SP5:                                                                              


    ECgene alternative splicing isoforms for ZC4H2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZC4H2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZC4H2 Expression
    About this image

    ZC4H2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZC4H2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.28249

    UniProtKB/Swiss-Prot: ZC4H2_HUMAN, Q9NQZ6
    Tissue specificity: Expressed in fetal tissues, including in brain, intestine, lung, kidney and muscle

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZC4H2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zc4h21 , 5 zinc finger, C4H2 domain containing1, 5 90.33(n)1
    100(a)1
      X (41.99 cM)5
    2455221  NM_001003916.11  NP_001003916.11 
     956391935 
    chicken
    (Gallus gallus)
    Aves ZC4H21 zinc finger, C4H2 domain containing 82.14(n)
    99.55(a)
      422176  XM_420173.4  XP_420173.3 
    lizard
    (Anolis carolinensis)
    Reptilia ZC4H26
    zinc finger, C4H2 domain containing
    98(a)
    1 ↔ 1
    GL343376.1(782731-794717)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.229802 Xenopus laevis transcribed sequence with strong similarity more 81.67(n)    BJ619595.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb99f082 wufb99f08 78.22(n)   323487  BC053110.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG130011 CG13001 63.17(n)
    58.01(a)
      32684  NM_132953.2  NP_573181.1 
    worm
    (Caenorhabditis elegans)
    Secernentea vab-236
    ZK930.26
    Protein ZK930.2 (ZK930.2) mRNA, complete cds
    28(a)
    24(a)
    many → 1
    many → 1
    II(11897363-11901212) WBGene00014153
    II(11890992-11893453) WBGene00014152


    ENSEMBL Gene Tree for ZC4H2 (if available)
    TreeFam Gene Tree for ZC4H2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZC4H2 (see all 1479)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0696224
    Wieacker-Wolf syndrome (WRWF)4--see VAR_0696222 R Q mis40--------
    VAR_0696214
    Wieacker-Wolf syndrome (WRWF)4--see VAR_0696212 V L mis40--------
    VAR_0696234
    Wieacker-Wolf syndrome (WRWF)4--see VAR_0696232 P S mis40--------
    VAR_0696244
    Wieacker-Wolf syndrome (WRWF)4--see VAR_0696242 R W mis40--------
    rs1888968641,2
    --64142269(+) CACATG/TATTAC 5 -- ds50010--------
    rs1816382211,2
    --64142373(+) ACAGAA/CCTGAC 5 -- ds50010--------
    rs1478664491,2
    C--64142408(+) CTATGA/GCCATG 5 -- ds50010--------
    rs1871949811,2
    --64142444(+) TAAGGA/CCTATA 5 -- ds50010--------
    rs1415495981,2
    --64142535(+) TCTGTA/TGCTAT 5 -- ds50010--------
    rs1470552641,2
    --64142601(+) CCAATA/CTACCT 5 -- ds50010--------

    HapMap Linkage Disequilibrium report for ZC4H2 (64136250 - 64254593 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ZC4H2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663820CNV Deletion23128226
    esv2675440CNV Deletion23128226
    dgv2449e1CNV Complex17122850
    esv1584074OTHER Inversion17803354

    Human Gene Mutation Database (HGMD): ZC4H2
    Locus Specific Mutation Databases (LSDB): ZC4H2

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300897   
    OMIM disorders: 314580  
    UniProtKB/Swiss-Prot: ZC4H2_HUMAN, Q9NQZ6
  • Wieacker-Wolf syndrome (WRWF) [MIM:314580]: A severe X-linked recessive neurodevelopmental disorder
    affecting the central and peripheral nervous systems. It is characterized by onset of muscle weakness in utero
    (fetal akinesia). Affected boys are born with severe contractures, known as arthrogryposis, and have delayed
    motor development, facial and bulbar weakness, characteristic dysmorphic facial features, and skeletal
    abnormalities, such as hip dislocation, scoliosis, and pes equinovarus. Those that survive infancy show mental
    retardation. Carrier females may have mild features of the disorder. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 10 diseases for ZC4H2:    
    About MalaCards
    wieacker-wolf syndrome    hepatocellular carcinoma    mental retardation    intellectual disability
    prostate cancer    prostatitis    multiple myeloma    myeloma
    malaria    neuronitis


    ZC4H2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZC4H2

    Export disorders for ZC4H2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZC4H2 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with ZC4H2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ZC4H2 mutations are associated with arthrogryposis multiplex congenita and intellectual disability through impairment of central and peripheral synaptic plasticity. (PubMed id 23623388)1, 2, 3 Hirata H.... Kalscheuer V.M. (Am. J. Hum. Genet. 2013)
    2. Large scale identification of human hepatocellular carcinoma- associated antigens by autoantibodies. (PubMed id 12097419)1, 2, 3 Wang Y....Chen W.-F. (J. Immunol. 2002)
    3. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2, 3 Hirosawa M.... Ohara O. (DNA Res. 1999)
    4. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. (PubMed id 20932654)1, 4 Kerns S.L....Rosenstein B.S. (Int. J. Radiat. Oncol. Biol. Phys. 2010)
    5. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. A computational approach to candidate gene prioritization for X-linked mental retardation using annotation-based binary filtering and motif-based linear discriminatory analysis. (PubMed id 21668950)1 Lombard Z....Ramsay M. (Biol. Direct 2011)
    10. Zinc fingers as biologic redox switches? (PubMed id 19132878)1 KrAPncke K.D. and Klotz L.O. (amp 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55906 HGNC: 24931 AceView: KIAA1166 Ensembl:ENSG00000126970 euGenes: HUgn55906
    ECgene: ZC4H2 H-InvDB: ZC4H2

    (According to HUGE)
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    HUGE: KIAA1166

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZC4H2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZC4H2 gene:
    Search GeneIP for patents involving ZC4H2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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