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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZC3HC1 Gene

protein-coding   GIFtS: 56
GCID: GC07M129658

Zinc Finger, C3HC-Type Containing 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger, C3HC-Type Containing 11 2     Nuclear-Interacting Partner Of ALK2
NIPA2 3     hNIPA3
Nuclear Interaction Partner Of ALK1     Nuclear-Interacting Partner Of Anaplastic Lymphoma Kinase3
Hematopoietic Stem/Progenitor Cell Protein 2162     Zinc Finger C3HC-Type Protein 13
Nuclear Interacting Partner Of Anaplastic Lymphoma Kinase (ALK)2     

External Ids:    HGNC: 299131   Entrez Gene: 515302   Ensembl: ENSG000000917327   UniProtKB: Q86WB03   

Export aliases for ZC3HC1 gene to outside databases

Previous GC identifers: GC07M129253 GC07M129445 GC07M124019


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZC3HC1 Gene:
This gene encodes an F-box-containing protein that is a component of an SCF-type E3 ubiquitin ligase complex that
regulates the onset of cell division. The G2/M transition in the cell cycle requires the interaction of the
proteins cyclin B1 and cyclin-dependent kinase 1. The activated ubiquitin ligase complex targets the protein
cyclin B1 for degradation, preventing this transition to mitosis. (provided by RefSeq, Aug 2013)

GeneCards Summary for ZC3HC1 Gene: 
ZC3HC1 (zinc finger, C3HC-type containing 1) is a protein-coding gene. Diseases associated with ZC3HC1 include ehrlichiosis, and hepatitis e, and among its related super-pathways are DNA Damage. GO annotations related to this gene include protein kinase binding and zinc ion binding.

UniProtKB/Swiss-Prot: NIPA_HUMAN, Q86WB0
Function: Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry
by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent
phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to
interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry.
May have an antiapoptotic role in NPM-ALK-mediated signaling events

Gene Wiki entry for ZC3HC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZC3HC1 gene promoter:
         Max1   GATA-1   AREB6   Max   CBF-A   CBF-B   STAT3   c-Myc   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZC3HC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZC3HC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZC3HC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32.2   Ensembl cytogenetic band:  7q32.2   HGNC cytogenetic band: 7q32.2

ZC3HC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZC3HC1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M129658:  view genomic region     (about GC identifiers)

Start:
129,658,126 bp from pter      End:
129,691,291 bp from pter
Size:
33,166 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 129,042,758-129,076,662     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NIPA_HUMAN, Q86WB0 (See protein sequence)
Recommended Name: Nuclear-interacting partner of ALK  
Size: 502 amino acids; 55262 Da
Subunit: Interacts with the NPM-ALK fusion protein in a tyrosine phosphorylation-dependent manner. Interacts with
SKP1. Component of a SCF(NIPA) E3 complex with SKP1, RBX1 and CUL1 when not phosphorylated on Ser-354. Interacts
with CCNB1
Subcellular location: Nucleus
Developmental stage: Weakly expressed in G0/G1 phases, abundant during S and G2/M phases, and strongly decreases
thereafter
Caution: Reported to contain a F-box domain (PubMed:16009132). Such domain is however not predicted by any
detection method
Sequence caution: Sequence=AAF36136.1; Type=Frameshift; Positions=93, 187, 220; Sequence=AAH28917.1;
Type=Erroneous initiation; Sequence=AAS07546.1; Type=Erroneous gene model prediction; Sequence=AAS07547.1;
Type=Erroneous gene model prediction;
Secondary accessions: A6NH66 Q75MF3 Q75MF4 Q8N330 Q96F75 Q9HA34 Q9NVX4 Q9P0R0
Alternative splicing: 3 isoforms:  Q86WB0-1   Q86WB0-2   Q86WB0-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZC3HC1: NX_Q86WB0

Explore proteomics data for ZC3HC1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated. Phosphorylated on Ser residues at G2/M phase, but not during S and G0 phases. May also be weakly
    phosphorylated on Tyr residues. Ser-354 phosphorylation, a major site during the course of cell-cycle-dedendent
    phosphorylation, results in its dissociation from the SCF(NIPA) complex, thereby preventing CCNB1 degradation
    leading to mitotic entry
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86WB0

  • ZC3HC1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZC3HC1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001269119.1  NP_001269120.1  NP_057562.3  

    ENSEMBL proteins: 
     ENSP00000351052   ENSP00000353933   ENSP00000419509   ENSP00000418533   ENSP00000417682  
     ENSP00000418407   ENSP00000420068   ENSP00000417217   ENSP00000309301  

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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0031965nuclear membrane IDA--

    ZC3HC1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZC3HC: Zinc fingers, C3HC-type

    2 InterPro protein domains:
     IPR013909 NIPA/Rsm1
     IPR012935 Znf_C3HC-like

    Graphical View of Domain Structure for InterPro Entry Q86WB0

    ProtoNet protein and cluster: Q86WB0

    1 Blocks protein domain: IPB012935 Zinc finger

    UniProtKB/Swiss-Prot: NIPA_HUMAN, Q86WB0
    Domain: The F-box-like region is required for the interaction with SKP1
    Similarity: Contains 1 C3HC-type zinc finger


    ZC3HC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NIPA_HUMAN, Q86WB0
    Function: Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry
    by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent
    phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to
    interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry.
    May have an antiapoptotic role in NPM-ALK-mediated signaling events

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16105984
    GO:0008270zinc ion binding IEA--
    GO:0019901protein kinase binding IPI16105984
         
    ZC3HC1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZC3HC1:
     Decreased viability of wild-ty 

         12 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Zc3hc1):
     behavior/neurological  cellular  craniofacial  endocrine/exocrine gland  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  no phenotypic analysis 
     reproductive system  skeleton 

    ZC3HC1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Zc3hc1tm1.2Jduy for ZC3HC1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZC3HC1 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZC3HC1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1DNA Damage
    Cell Cycle / Checkpoint Control0.32
    2Apoptosis and Autophagy
    Apoptosis and Autophagy
    3Protein Stability
    Protein Stability

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for ZC3HC1
        Apoptosis and Autophagy
    Cell Cycle / Checkpoint Control
    Protein Stability


    UniProtKB/Swiss-Prot: NIPA_HUMAN, Q86WB0
    Pathway: Protein modification; protein ubiquitination


    ZC3HC1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZC3HC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/562 Interacting proteins for ZC3HC1 (Q86WB02, 3 ENSP000003510524) via UniProtKB, MINT, STRING, and/or I2D (see all 562)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCNB1P146352, 3, ENSP000002564424MINT-7947479 I2D: score=2 STRING: ENSP00000256442
    PDPK1O155302, 3MINT-8265665 I2D: score=2 
    TNFSF11O147882, 3MINT-8274797 I2D: score=2 
    TSC22D1Q157142, 3MINT-8275644 I2D: score=2 
    CUL1Q136162, 3, ENSP000003268044MINT-7947479 I2D: score=2 STRING: ENSP00000326804
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007067mitosis IEA--
    GO:0016567protein ubiquitination IEA--
    GO:0043066negative regulation of apoptotic process IEA--
    GO:0051301cell division IEA--

    ZC3HC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZC3HC1 (NIPA)

    Search CenterWatch for drugs/clinical trials and news about ZC3HC1 / NIPA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZC3HC1 gene (3 alternative transcripts): 
    NM_001282190.1  NM_001282191.1  NM_016478.4  

    Unigene Cluster for ZC3HC1:

    Zinc finger, C3HC-type containing 1
    Hs.194157  [show with all ESTs]
    Unigene Representative Sequence: NM_016478
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358303(uc010lma.3 uc003vpi.3) ENST00000360708 ENST00000467642
    ENST00000481503 ENST00000477578 ENST00000471022 ENST00000483827 ENST00000480193
    ENST00000470651 ENST00000484432 ENST00000311873
    miRNA
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    Additional mRNA sequence: 

    AF151050.1 AJ537494.1 AK001317.1 AK022373.1 BC000190.1 BC011551.1 BC028917.1 

    12 DOTS entries:

    DT.316743  DT.100774889  DT.40108337  DT.75177243  DT.91787394  DT.100738541  DT.100804029  DT.121039330 
    DT.95193685  DT.100786778  DT.121039322  DT.92435144 

    24/211 AceView cDNA sequences (see all 211):

    CR607048 BQ651666 BM823327 BM843455 BM719894 BI224212 BQ645081 BX384219 
    BQ962845 BM795918 BU194234 BU844456 BU540711 AJ537494 BM795545 BM466507 
    CR618908 CB137494 BM013594 BC000190 CR617545 BQ653235 BX333474 CR603577 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZC3HC1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15
    SP1:                                      -     -     -     -     -           -                 -                                                               
    SP2:                          -           -     -     -     -     -           -                 -                                                               
    SP3:                          -                 -     -     -     -     -     -                 -                                                               
    SP4:                                                                                            -                                                               
    SP5:                          -     -     -           -           -           -                                                                                 


    ECgene alternative splicing isoforms for ZC3HC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZC3HC1 expression in normal human tissues (normalized intensities)      ZC3HC1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTCTGTTAA
    ZC3HC1 Expression
    About this image


    ZC3HC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See ZC3HC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZC3HC1

    SOURCE GeneReport for Unigene cluster: Hs.194157

    UniProtKB/Swiss-Prot: NIPA_HUMAN, Q86WB0
    Tissue specificity: Widely expressed. Highly expressed in heart, skeletal muscle and testis. Expressed in brain,
    placenta, lung, kidney, liver, pancreas, spleen, thymus, prostate, ovary small intestine and colon. Weakly or not
    expressed in leukocytes

        SABiosciences Expression via Pathway-Focused PCR Array including ZC3HC1: 
              Apoptosis 384HT in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC3HC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZC3HC1 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zc3hc11 , 5 zinc finger, C3HC type 11, 5 84.06(n)1
    85.18(a)1
      6 (12.52 cM)5
    2326791  NM_172735.21  NP_766323.11 
     303663805 
    chicken
    (Gallus gallus)
    Aves ZC3HC11 zinc finger, C3HC-type containing 1 65.76(n)
    65.34(a)
      416679  NM_001199437.1  NP_001186366.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZC3HC16
    Uncharacterized protein
    59(a)
    1 ↔ 1
    GL343708.1(158801-194906)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC687112 hypothetical protein MGC68711 75.12(n)    BC061669.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zc3hc11 zinc finger, C3HC-type containing 1 57.11(n)
    49.45(a)
      560141  NM_001077378.1  NP_001070846.1 


    ENSEMBL Gene Tree for ZC3HC1 (if available)
    TreeFam Gene Tree for ZC3HC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZC3HC1 gene
    1 SIMAP similar gene for ZC3HC1 using alignment to 8 protein entries:     NIPA_HUMAN (see all proteins):
    NIPA

    ZC3HC1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/741 SNPs in ZC3HC1 are shown (see all 741)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs584300721,2
    C--129052669(+) AAAAA-/AA    
       
    /AAAA
    GATAT
    1 -- int11NA 2
    rs1407577881,2
    --129657635(+) TACTTC/TAGTAC 1 -- int10--------
    rs1446269881,2
    C--129657687(+) CATATC/TAGAGA 1 -- int10--------
    rs734796821,2
    C--129657851(+) GAGGGG/TTCTCT 1 -- int11Minor allele frequency- T:0.50WA 2
    rs22424871,2
    C,F,A,H--129657882(+) ATTACG/ATTGTT 1 -- int126Minor allele frequency- A:0.41EA NS NA WA 3194
    rs1128433751,2
    F--129658049(+) GCCAAC/TCTGAA 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs113476061,2
    C--129658062(+) TCAAA-/AGTTGA 1 -- int10--------
    rs1412200421,2
    --129658066(+) AAGTTA/GAATGT 1 -- int10--------
    rs559020621,2
    C,F--129658088(+) TTCTCC/GGGCCC 1 -- int11Minor allele frequency- G:0.02NA 120
    rs19970811,2
    C,H--129658259(+) GTTAAC/TCCCAC 1 -- ut31 ese316Minor allele frequency- T:0.02NA WA CSA EA 513

    HapMap Linkage Disequilibrium report for ZC3HC1 (129658126 - 129691291 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ZC3HC1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2735152CNV Deletion23290073
    esv2665890CNV Deletion23128226
    nsv831129CNV Loss17160897
    nsv824305CNV Loss20364138
    nsv510968CNV Complex20534489


    Human Gene Mutation Database (HGMD): ZC3HC1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZC3HC1
    DNA2.0 Custom Variant and Variant Library Synthesis for ZC3HC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    5 diseases for ZC3HC1:    About MalaCards
    ehrlichiosis    hepatitis e    gigantism    hepatitis
    prostatitis


    ZC3HC1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZC3HC1
    Human Genome Epidemiology (HuGE) Navigator: ZC3HC1 (2 documents)

    Export disorders for ZC3HC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZC3HC1 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with ZC3HC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
    2. Identification and characterization of a nuclear interacting partner of anaplastic lymphoma kinase (NIPA). (PubMed id 12748172)1, 2, 9 Ouyang T.... Duyster J. (2003)
    3. Large-scale association analysis identifies 13 new su sceptibility loci for coronary artery disease. (PubMed id 21378990)1, 4 Schunkert H....Samani N.J. (2011)
    4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. NIPA defines an SCF-type mammalian E3 ligase that regulates mitotic entry. (PubMed id 16009132)1, 2 Bassermann F.... Duyster J. (2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51530 HGNC: 29913 AceView: NIPA Ensembl:ENSG00000091732 euGenes: HUgn51530
    ECgene: ZC3HC1 H-InvDB: ZC3HC1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZC3HC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ZC3HC1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZC3HC1 gene:
    Search GeneIP for patents involving ZC3HC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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