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Aliases for ZC3HC1 Gene

Aliases for ZC3HC1 Gene

  • Zinc Finger C3HC-Type Containing 1 2 3
  • Zinc Finger, C3HC-Type Containing 1 3 5
  • NIPA 3 4
  • Nuclear Interacting Partner Of Anaplastic Lymphoma Kinase (ALK) 3
  • Nuclear-Interacting Partner Of Anaplastic Lymphoma Kinase 4
  • Hematopoietic Stem/Progenitor Cell Protein 216 3
  • Nuclear Interaction Partner Of ALK 2
  • Zinc Finger C3HC-Type Protein 1 4
  • HSPC216 3
  • HNIPA 4

External Ids for ZC3HC1 Gene

Previous GeneCards Identifiers for ZC3HC1 Gene

  • GC07M129253
  • GC07M129445
  • GC07M129658
  • GC07M124019

Summaries for ZC3HC1 Gene

Entrez Gene Summary for ZC3HC1 Gene

  • This gene encodes an F-box-containing protein that is a component of an SCF-type E3 ubiquitin ligase complex that regulates the onset of cell division. The G2/M transition in the cell cycle requires the interaction of the proteins cyclin B1 and cyclin-dependent kinase 1. The activated ubiquitin ligase complex targets the protein cyclin B1 for degradation, preventing this transition to mitosis. [provided by RefSeq, Aug 2013]

GeneCards Summary for ZC3HC1 Gene

ZC3HC1 (Zinc Finger C3HC-Type Containing 1) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot for ZC3HC1 Gene

  • Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.

Gene Wiki entry for ZC3HC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3HC1 Gene

Genomics for ZC3HC1 Gene

Regulatory Elements for ZC3HC1 Gene

Promoters for ZC3HC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZC3HC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZC3HC1 Gene

Chromosome:
7
Start:
130,018,286 bp from pter
End:
130,051,451 bp from pter
Size:
33,166 bases
Orientation:
Minus strand

Genomic View for ZC3HC1 Gene

Genes around ZC3HC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC3HC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC3HC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3HC1 Gene

Proteins for ZC3HC1 Gene

  • Protein details for ZC3HC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WB0-NIPA_HUMAN
    Recommended name:
    Nuclear-interacting partner of ALK
    Protein Accession:
    Q86WB0
    Secondary Accessions:
    • A6NH66
    • Q75MF3
    • Q75MF4
    • Q8N330
    • Q96F75
    • Q9HA34
    • Q9NVX4
    • Q9P0R0

    Protein attributes for ZC3HC1 Gene

    Size:
    502 amino acids
    Molecular mass:
    55262 Da
    Quaternary structure:
    • Interacts with the NPM-ALK fusion protein in a tyrosine phosphorylation-dependent manner. Interacts with SKP1. Component of a SCF(NIPA) E3 complex with SKP1, RBX1 and CUL1 when not phosphorylated on Ser-354. Interacts with CCNB1.
    SequenceCaution:
    • Sequence=AAF36136.1; Type=Frameshift; Positions=93, 187, 220; Evidence={ECO:0000305}; Sequence=AAH28917.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAS07546.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAS07547.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZC3HC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZC3HC1 Gene

Proteomics data for ZC3HC1 Gene at MOPED

Post-translational modifications for ZC3HC1 Gene

  • Phosphorylated. Phosphorylated on Ser residues at G2/M phase, but not during S and G0 phases. May also be weakly phosphorylated on Tyr residues. Ser-354 phosphorylation, a major site during the course of cell-cycle-dedendent phosphorylation, results in its dissociation from the SCF(NIPA) complex, thereby preventing CCNB1 degradation leading to mitotic entry.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ZC3HC1 (NIPA)

No data available for DME Specific Peptides for ZC3HC1 Gene

Domains & Families for ZC3HC1 Gene

Gene Families for ZC3HC1 Gene

Protein Domains for ZC3HC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q86WB0

UniProtKB/Swiss-Prot:

NIPA_HUMAN :
  • The F-box-like region is required for the interaction with SKP1.
  • Contains 1 C3HC-type zinc finger.
Domain:
  • The F-box-like region is required for the interaction with SKP1.
Similarity:
  • Contains 1 C3HC-type zinc finger.
genes like me logo Genes that share domains with ZC3HC1: view

Function for ZC3HC1 Gene

Molecular function for ZC3HC1 Gene

UniProtKB/Swiss-Prot Function:
Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.

Gene Ontology (GO) - Molecular Function for ZC3HC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16105984
genes like me logo Genes that share ontologies with ZC3HC1: view
genes like me logo Genes that share phenotypes with ZC3HC1: view

Animal Models for ZC3HC1 Gene

MGI Knock Outs for ZC3HC1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ZC3HC1 Gene

Localization for ZC3HC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZC3HC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZC3HC1 Gene COMPARTMENTS Subcellular localization image for ZC3HC1 gene
Compartment Confidence
nucleus 5
cytosol 2
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for ZC3HC1 Gene

Pathways & Interactions for ZC3HC1 Gene

SuperPathways for ZC3HC1 Gene

No Data Available

UniProtKB/Swiss-Prot Q86WB0-NIPA_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for ZC3HC1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for ZC3HC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA --
genes like me logo Genes that share ontologies with ZC3HC1: view

No data available for Pathways by source for ZC3HC1 Gene

Drugs & Compounds for ZC3HC1 Gene

No Compound Related Data Available

Transcripts for ZC3HC1 Gene

Unigene Clusters for ZC3HC1 Gene

Zinc finger, C3HC-type containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3HC1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: -
SP5: - - - - - -
SP6: - - - - - - -
SP7: - -
SP8: - -
SP9: - - -

Relevant External Links for ZC3HC1 Gene

GeneLoc Exon Structure for
ZC3HC1
ECgene alternative splicing isoforms for
ZC3HC1

Expression for ZC3HC1 Gene

mRNA expression in normal human tissues for ZC3HC1 Gene

Protein differential expression in normal tissues from HIPED for ZC3HC1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZC3HC1 Gene



SOURCE GeneReport for Unigene cluster for ZC3HC1 Gene Hs.194157

mRNA Expression by UniProt/SwissProt for ZC3HC1 Gene

Q86WB0-NIPA_HUMAN
Tissue specificity: Widely expressed. Highly expressed in heart, skeletal muscle and testis. Expressed in brain, placenta, lung, kidney, liver, pancreas, spleen, thymus, prostate, ovary small intestine and colon. Weakly or not expressed in leukocytes.
genes like me logo Genes that share expression patterns with ZC3HC1: view

Protein tissue co-expression partners for ZC3HC1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZC3HC1 Gene

Orthologs for ZC3HC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZC3HC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZC3HC1 35
  • 99.47 (n)
  • 99.4 (a)
ZC3HC1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZC3HC1 36
  • 91 (a)
OneToOne
ZC3HC1 35
  • 89.75 (n)
  • 91.22 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 91 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zc3hc1 36
  • 85 (a)
OneToOne
Zc3hc1 16
Zc3hc1 35
  • 84.06 (n)
  • 85.18 (a)
oppossum
(Monodelphis domestica)
Mammalia ZC3HC1 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZC3HC1 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zc3hc1 35
  • 84.33 (n)
  • 86.2 (a)
chicken
(Gallus gallus)
Aves ZC3HC1 36
  • 64 (a)
OneToOne
ZC3HC1 35
  • 65.83 (n)
  • 65.34 (a)
lizard
(Anolis carolinensis)
Reptilia ZC3HC1 36
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68711 35
tropical clawed frog
(Silurana tropicalis)
Amphibia zc3hc1 35
  • 59.62 (n)
  • 56.61 (a)
zebrafish
(Danio rerio)
Actinopterygii zc3hc1 36
  • 45 (a)
OneToOne
zc3hc1 35
  • 56.11 (n)
  • 48.69 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8987 36
  • 23 (a)
OneToOne
Species with no ortholog for ZC3HC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZC3HC1 Gene

ENSEMBL:
Gene Tree for ZC3HC1 (if available)
TreeFam:
Gene Tree for ZC3HC1 (if available)

Paralogs for ZC3HC1 Gene

(1) SIMAP similar genes for ZC3HC1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with ZC3HC1: view

No data available for Paralogs for ZC3HC1 Gene

Variants for ZC3HC1 Gene

Sequence variations from dbSNP and Humsavar for ZC3HC1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1464890 - 130,024,472(+) ACATG(C/T)TATCA reference, missense
rs11556924 - 130,023,656(+) CAGGA(C/T)GGTCA intron-variant, reference, missense
rs867704 -- 130,051,469(+) AAAGT(C/G)TAACC upstream-variant-2KB
rs1997082 -- 130,023,046(+) GCTGC(A/G)GGTTC intron-variant
rs3807123 -- 130,021,547(+) ACAGT(A/C)TGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZC3HC1 Gene

Variant ID Type Subtype PubMed ID
nsv831129 CNV Loss 17160897
nsv510968 CNV Complex 20534489
esv2735152 CNV Deletion 23290073
esv2665890 CNV Deletion 23128226
nsv824305 CNV Loss 20364138

Variation tolerance for ZC3HC1 Gene

Residual Variation Intolerance Score: 41.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.41; 94.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZC3HC1 Gene

HapMap Linkage Disequilibrium report
ZC3HC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC3HC1 Gene

Disorders for ZC3HC1 Gene

Relevant External Links for ZC3HC1

Genetic Association Database (GAD)
ZC3HC1
Human Genome Epidemiology (HuGE) Navigator
ZC3HC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZC3HC1

No disorders were found for ZC3HC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZC3HC1 Gene

Publications for ZC3HC1 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 67
  2. Identification and characterization of a nuclear interacting partner of anaplastic lymphoma kinase (NIPA). (PMID: 12748172) Ouyang T. … Duyster J. (J. Biol. Chem. 2003) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. (PMID: 24262325) Dichgans M. … . (Stroke 2014) 3
  5. The ZC3HC1 rs11556924 polymorphism is associated with increased carotid intima-media thickness in patients with rheumatoid arthritis. (PMID: 24286297) LA^pez-MejA-as R. … GonzA!lez-Gay M.A. (Arthritis Res. Ther. 2013) 3

Products for ZC3HC1 Gene

Sources for ZC3HC1 Gene

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