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Aliases for ZC3HAV1L Gene

Aliases for ZC3HAV1L Gene

  • Zinc Finger CCCH-Type Containing, Antiviral 1 Like 2 3 5
  • C7orf39 3 4
  • Zinc Finger CCCH-Type Antiviral Protein 1-Like 3
  • Zinc Finger CCCH-Type, Antiviral 1-Like 3
  • Chromosome 7 Open Reading Frame 39 2

External Ids for ZC3HAV1L Gene

Previous HGNC Symbols for ZC3HAV1L Gene

  • C7orf39

Previous GeneCards Identifiers for ZC3HAV1L Gene

  • GC07M138357
  • GC07M138706
  • GC07M133020

Summaries for ZC3HAV1L Gene

GeneCards Summary for ZC3HAV1L Gene

ZC3HAV1L (Zinc Finger CCCH-Type Containing, Antiviral 1 Like) is a Protein Coding gene.

Additional gene information for ZC3HAV1L Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3HAV1L Gene

Genomics for ZC3HAV1L Gene

Regulatory Elements for ZC3HAV1L Gene

Enhancers for ZC3HAV1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H139101 2.1 FANTOM5 Ensembl ENCODE dbSUPER 19 -71.0 -70998 11 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 YY1 LUC7L2 UBN2 TTC26 ZC3HAV1 ZC3HAV1L PARP12 RPL17P28
GH07H139851 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -817.8 -817791 4 HDGF PKNOX1 TCF12 ZNF766 CBX5 GATA2 ELK1 FOS ATF7 RUNX3 TBXAS1 HIPK2 SLC37A3 LUC7L2 ZC3HAV1L KDM7A GC07P139864
GH07H139724 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.9 -695.7 -695655 15 HDGF FOXA2 ZFP64 ZNF133 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF143 SLC37A3 LUC7L2 TBXAS1 HIPK2 UBN2 ZC3HAV1L PARP12 KDM7A TMEM213 KIAA1549
GH07H139074 1.4 Ensembl ENCODE dbSUPER 11.9 -39.0 -38988 1 HDAC1 FOXA2 RB1 RAD21 RFX5 ZNF143 ATF7 RUNX3 DEK ZNF654 ZC3HAV1 ZC3HAV1L KIAA1549 RPL17P28
GH07H139043 1.5 Ensembl ENCODE dbSUPER 10.2 -8.1 -8083 2 HDGF PKNOX1 FOXA2 ATF1 ARNT TCF12 ZNF766 GATA2 FOS ATF7 KIAA1549 ZC3HAV1L LUC7L2 RPL17P28
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZC3HAV1L on UCSC Golden Path with GeneCards custom track

Promoters for ZC3HAV1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000218905 789 1401 ELF3 TBP HDGF RB1 ARNT SIN3A DMAP1 ZNF143 ZNF207 THAP11

Genomic Location for ZC3HAV1L Gene

Chromosome:
7
Start:
139,021,498 bp from pter
End:
139,036,489 bp from pter
Size:
14,992 bases
Orientation:
Minus strand

Genomic View for ZC3HAV1L Gene

Genes around ZC3HAV1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC3HAV1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC3HAV1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3HAV1L Gene

Proteins for ZC3HAV1L Gene

  • Protein details for ZC3HAV1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96H79-ZCCHL_HUMAN
    Recommended name:
    Zinc finger CCCH-type antiviral protein 1-like
    Protein Accession:
    Q96H79
    Secondary Accessions:
    • Q8WUD9

    Protein attributes for ZC3HAV1L Gene

    Size:
    300 amino acids
    Molecular mass:
    32962 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZC3HAV1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZC3HAV1L Gene

Post-translational modifications for ZC3HAV1L Gene

  • Ubiquitination at isoforms=141 and isoforms=174
  • Modification sites at PhosphoSitePlus

Other Protein References for ZC3HAV1L Gene

No data available for DME Specific Peptides for ZC3HAV1L Gene

Domains & Families for ZC3HAV1L Gene

Gene Families for ZC3HAV1L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZC3HAV1L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZC3HAV1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZC3HAV1L: view

No data available for UniProtKB/Swiss-Prot for ZC3HAV1L Gene

Function for ZC3HAV1L Gene

Phenotypes From GWAS Catalog for ZC3HAV1L Gene

Gene Ontology (GO) - Molecular Function for ZC3HAV1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZC3HAV1L: view
genes like me logo Genes that share phenotypes with ZC3HAV1L: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ZC3HAV1L

CRISPR Products

miRNA for ZC3HAV1L Gene

miRTarBase miRNAs that target ZC3HAV1L

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZC3HAV1L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZC3HAV1L Gene

Localization for ZC3HAV1L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZC3HAV1L gene
Compartment Confidence
cytosol 5
extracellular 3
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZC3HAV1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZC3HAV1L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZC3HAV1L Gene

Pathways & Interactions for ZC3HAV1L Gene

SuperPathways for ZC3HAV1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZC3HAV1L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZC3HAV1L Gene

Drugs & Compounds for ZC3HAV1L Gene

No Compound Related Data Available

Transcripts for ZC3HAV1L Gene

mRNA/cDNA for ZC3HAV1L Gene

Unigene Clusters for ZC3HAV1L Gene

Zinc finger CCCH-type, antiviral 1-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZC3HAV1L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3HAV1L Gene

No ASD Table

Relevant External Links for ZC3HAV1L Gene

GeneLoc Exon Structure for
ZC3HAV1L
ECgene alternative splicing isoforms for
ZC3HAV1L

Expression for ZC3HAV1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZC3HAV1L Gene

Protein differential expression in normal tissues from HIPED for ZC3HAV1L Gene

This gene is overexpressed in Uterus (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZC3HAV1L Gene



Protein tissue co-expression partners for ZC3HAV1L Gene

NURSA nuclear receptor signaling pathways regulating expression of ZC3HAV1L Gene:

ZC3HAV1L

SOURCE GeneReport for Unigene cluster for ZC3HAV1L Gene:

Hs.512833

Evidence on tissue expression from TISSUES for ZC3HAV1L Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZC3HAV1L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZC3HAV1L Gene

Orthologs for ZC3HAV1L Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZC3HAV1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZC3HAV1L 33 34
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia ZC3HAV1L 34 33
  • 86.62 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZC3HAV1L 33 34
  • 85.55 (n)
mouse
(Mus musculus)
Mammalia Zc3hav1l 33 16 34
  • 82.64 (n)
rat
(Rattus norvegicus)
Mammalia Zc3hav1l 33
  • 82.19 (n)
oppossum
(Monodelphis domestica)
Mammalia ZC3HAV1L 34
  • 48 (a)
OneToOne
Species where no ortholog for ZC3HAV1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZC3HAV1L Gene

ENSEMBL:
Gene Tree for ZC3HAV1L (if available)
TreeFam:
Gene Tree for ZC3HAV1L (if available)

Paralogs for ZC3HAV1L Gene

(2) SIMAP similar genes for ZC3HAV1L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZC3HAV1L: view

No data available for Paralogs for ZC3HAV1L Gene

Variants for ZC3HAV1L Gene

Sequence variations from dbSNP and Humsavar for ZC3HAV1L Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000028558 -- 139,022,820(+) CTGGC(A/G)TTTTG utr-variant-3-prime
rs1000080852 -- 139,033,673(+) CAAGA(C/T)ACATC intron-variant
rs1000083505 -- 139,022,537(+) GAGAC(C/T)CTGTC utr-variant-3-prime
rs1000166988 -- 139,022,782(+) TACAA(A/G)AGTCA utr-variant-3-prime
rs1000217817 -- 139,034,063(+) CTTGA(A/G)AGCAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZC3HAV1L Gene

Variant ID Type Subtype PubMed ID
dgv6640n100 CNV gain 25217958
esv2735212 CNV deletion 23290073
nsv831155 CNV loss 17160897

Variation tolerance for ZC3HAV1L Gene

Residual Variation Intolerance Score: 70.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.85; 58.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZC3HAV1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZC3HAV1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC3HAV1L Gene

Disorders for ZC3HAV1L Gene

Relevant External Links for ZC3HAV1L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZC3HAV1L

No disorders were found for ZC3HAV1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZC3HAV1L Gene

Publications for ZC3HAV1L Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  2. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 60
  3. FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1. (PMID: 26752685) Scholz CC … Taylor CT (PLoS biology 2016) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q … Chinnaiyan AM (Nature communications 2014) 3 60

Products for ZC3HAV1L Gene

Sources for ZC3HAV1L Gene

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