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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZC3HAV1L Gene

protein-coding   GIFtS: 42
GCID: GC07M138706

Zinc Finger CCCH-Type, Antiviral 1-Like

(Previous name: chromosome 7 open reading frame 39)
(Previous symbol: C7orf39)
  Search for ZC3HAV1L
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger CCCH-Type, Antiviral 1-Like1 2
C7orf391 2 3
Chromosome 7 Open Reading Frame 391
Zinc Finger CCCH-Type Antiviral Protein 1-Like2

External Ids:    HGNC: 224231   Entrez Gene: 920922   Ensembl: ENSG000001468587   UniProtKB: Q96H793   

Export aliases for ZC3HAV1L gene to outside databases

Previous GC identifers: GC07M138357 GC07M133020


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZC3HAV1L Gene: 
ZC3HAV1L (zinc finger CCCH-type, antiviral 1-like) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZC3HAV1L gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   Nkx2-5   POU2F2   POU2F2C   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZC3HAV1L promoter sequence
   Search SABiosciences Chromatin IP Primers for ZC3HAV1L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZC3HAV1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

ZC3HAV1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZC3HAV1L gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M138706:  view genomic region     (about GC identifiers)

Start:
138,710,452 bp from pter      End:
138,720,775 bp from pter
Size:
10,324 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 138,054,670-138,064,994     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZCCHL_HUMAN, Q96H79 (See protein sequence)
Recommended Name: Zinc finger CCCH-type antiviral protein 1-like  
Size: 300 amino acids; 32962 Da
Caution: Despite its name, it does not contain a canonical C3H1-type zinc-finger
Secondary accessions: Q8WUD9
Alternative splicing: 2 isoforms:  Q96H79-1   Q96H79-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZC3HAV1L: NX_Q96H79

Explore proteomics data for ZC3HAV1L at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96H79

  • ZC3HAV1L Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZC3HAV1L Protein Expression
    REFSEQ proteins: NP_542391.2  
    ENSEMBL proteins: 
     ENSP00000275766  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026693 Zc3hav1_like

    Graphical View of Domain Structure for InterPro Entry Q96H79

    ProtoNet protein and cluster: Q96H79


    ZC3HAV1L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         2 GenomeRNAi human phenotypes for ZC3HAV1L:
     Increased homologous recombina  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZC3HAV1L 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZC3HAV1L

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/6 Interacting proteins for ZC3HAV1L (Q96H793 ENSP000002757664) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TERF1P542743, ENSP000002766034I2D: score=1 STRING: ENSP00000276603
    TERF2Q155543, ENSP000002549424I2D: score=1 STRING: ENSP00000254942
    FYCO1Q9BQS83I2D: score=1 
    GABARAPO951663I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZC3HAV1L (ZCCHL)

    Search CenterWatch for drugs/clinical trials and news about ZC3HAV1L / ZCCHL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZC3HAV1L gene: 
    NM_080660.3  

    Unigene Clusters for ZC3HAV1L:

    Zinc finger CCCH-type, antiviral 1-like
    Hs.512833  [show with all ESTs], Hs.659143  [show with all ESTs]
    Unigene Representative Sequences: AK098156, BC008842
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000275766(uc003vum.1)
    miRNA
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    hsa-miR-374b* hsa-miR-3690 hsa-miR-548n hsa-miR-874 hsa-miR-4308
    SwitchGear 3'UTR luciferase reporter plasmidZC3HAV1L 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZC3HAV1L
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    Additional mRNA sequence: BC008842.2 

    5 DOTS entries:

    DT.210316  DT.97836975  DT.40306625  DT.95124197  DT.91858903 

    24/40 AceView cDNA sequences (see all 40):

    BC008842 NM_080660 CB123827 BM470887 CK431013 BX099074 AK098156 BF316695 
    CB215232 AI540088 BU929885 AL697647 AA775256 AW293784 BE892975 BG613375 
    N59413 BG705732 BF516126 BM800000 AA425468 BG392723 N77096 W01925 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZC3HAV1L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAATCTCTA
    ZC3HAV1L Expression
    About this image


    See ZC3HAV1L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZC3HAV1L

    SOURCE GeneReport for Unigene clusters: Hs.512833 Hs.659143
        SABiosciences Custom PCR Arrays for ZC3HAV1L
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC3HAV1L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZC3HAV1L gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zc3hav1l1 , 5 zinc finger CCCH-type, antiviral 1-like1, 5 82.99(n)1
    77.24(a)1
      6 (17.71 cM)5
    2090321  NM_172467.31  NP_766055.11 
     382873965 


    ENSEMBL Gene Tree for ZC3HAV1L (if available)
    TreeFam Gene Tree for ZC3HAV1L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZC3HAV1L gene
    2 SIMAP similar genes for ZC3HAV1L using alignment to 1 protein entry:     ZCCHL_HUMAN:
    PARP12    ZC3HAV1

    ZC3HAV1L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/328 SNPs in ZC3HAV1L are shown (see all 328)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1818575621,2
    C--138709981(+) CCTGAA/GGTCAG 1 -- int10--------
    rs1476754041,2
    C--138710055(+) TGGGCA/GTGGTG 1 -- int10--------
    rs1409766011,2
    C--138710075(+) TGTAAC/TCTCAG 1 -- int10--------
    rs1502208971,2
    C--138710107(+) GAGAAC/TCACTT 1 -- int10--------
    rs1457875951,2
    C--138710125(+) GGAGGC/TGGAGG 1 -- int10--------
    rs113996881,2
    C--138710195(+) AAAAA-/AAAAAA 1 -- int1 trp31Minor allele frequency- A:0.50NA 2
    rs1148053081,2
    C,F--138710277(+) TGGCTG/AAGGAT 1 -- int11Minor allele frequency- A:0.04WA 118
    rs752979471,2
    F--138710300(+) ATTGAA/GTATCA 1 -- int11Minor allele frequency- G:0.02WA 118
    rs1872762641,2
    --138710451(+) CCAGAA/GAACTA 1 -- spd10--------
    rs1163549851,2
    F--138710477(+) ATTTTT/AAAAAA 1 -- ut312Minor allele frequency- A:0.03WA NA 238

    HapMap Linkage Disequilibrium report for ZC3HAV1L (138710452 - 138720775 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZC3HAV1L:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2735212CNV Deletion23290073
    nsv831155CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZC3HAV1L gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with ZC3HAV1L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    2. Detection of a common chimeric transcript between huma n chromosomes 7 and 16. (PubMed id 23273016)1 Fang W....Landweber L.F. (2012)
    3. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    4. Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)
    5. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
    6. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    9. The protein network surrounding the human telomere re peat binding factors TRF1, TRF2, and POT1. (PubMed id 20811636)1 Giannone R.J....Liu Y. (2010)
    10. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 92092 HGNC: 22423 AceView: MGC14289 Ensembl:ENSG00000146858 euGenes: HUgn92092
    ECgene: ZC3HAV1L H-InvDB: ZC3HAV1L

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZC3HAV1L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZC3HAV1L gene:
    Search GeneIP for patents involving ZC3HAV1L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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